-- dump date 20140619_103139 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1173026000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1173026000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1173026000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026000004 Walker A motif; other site 1173026000005 ATP binding site [chemical binding]; other site 1173026000006 Walker B motif; other site 1173026000007 arginine finger; other site 1173026000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1173026000009 DnaA box-binding interface [nucleotide binding]; other site 1173026000010 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1173026000011 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1173026000012 active site 1173026000013 (T/H)XGH motif; other site 1173026000014 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1173026000015 PHP domain; Region: PHP; pfam02811 1173026000016 active site 1173026000017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026000018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000019 active site 1173026000020 phosphorylation site [posttranslational modification] 1173026000021 intermolecular recognition site; other site 1173026000022 dimerization interface [polypeptide binding]; other site 1173026000023 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026000024 DNA binding residues [nucleotide binding] 1173026000025 dimerization interface [polypeptide binding]; other site 1173026000026 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1173026000027 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173026000028 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173026000029 protein binding site [polypeptide binding]; other site 1173026000030 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173026000031 Catalytic dyad [active] 1173026000032 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173026000033 DHH family; Region: DHH; pfam01368 1173026000034 DHHA1 domain; Region: DHHA1; pfam02272 1173026000035 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026000036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026000037 Coenzyme A binding pocket [chemical binding]; other site 1173026000038 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173026000039 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1173026000040 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026000041 GAF domain; Region: GAF; pfam01590 1173026000042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026000043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026000044 metal binding site [ion binding]; metal-binding site 1173026000045 active site 1173026000046 I-site; other site 1173026000047 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026000048 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 1173026000049 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 1173026000050 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1173026000051 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1173026000052 Mg++ binding site [ion binding]; other site 1173026000053 putative catalytic motif [active] 1173026000054 putative substrate binding site [chemical binding]; other site 1173026000055 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1173026000056 MPT binding site; other site 1173026000057 trimer interface [polypeptide binding]; other site 1173026000058 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 1173026000059 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1173026000060 putative active site [active] 1173026000061 dimerization interface [polypeptide binding]; other site 1173026000062 putative tRNAtyr binding site [nucleotide binding]; other site 1173026000063 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1173026000064 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173026000065 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173026000066 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173026000067 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1173026000068 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173026000069 active site 1173026000070 HIGH motif; other site 1173026000071 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1173026000072 KMSKS motif; other site 1173026000073 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1173026000074 tRNA binding surface [nucleotide binding]; other site 1173026000075 anticodon binding site; other site 1173026000076 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026000077 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026000078 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1173026000079 Beta-lactamase; Region: Beta-lactamase; pfam00144 1173026000080 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173026000081 EamA-like transporter family; Region: EamA; pfam00892 1173026000082 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026000083 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000084 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026000086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000087 active site 1173026000088 phosphorylation site [posttranslational modification] 1173026000089 intermolecular recognition site; other site 1173026000090 dimerization interface [polypeptide binding]; other site 1173026000091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026000092 DNA binding residues [nucleotide binding] 1173026000093 dimerization interface [polypeptide binding]; other site 1173026000094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026000095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026000096 dimer interface [polypeptide binding]; other site 1173026000097 phosphorylation site [posttranslational modification] 1173026000098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000099 ATP binding site [chemical binding]; other site 1173026000100 Mg2+ binding site [ion binding]; other site 1173026000101 G-X-G motif; other site 1173026000102 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1173026000103 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1173026000104 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026000105 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026000106 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1173026000107 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173026000108 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 1173026000109 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1173026000110 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1173026000111 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1173026000112 Ligand Binding Site [chemical binding]; other site 1173026000113 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1173026000114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026000115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026000116 active site 1173026000117 ATP binding site [chemical binding]; other site 1173026000118 substrate binding site [chemical binding]; other site 1173026000119 activation loop (A-loop); other site 1173026000120 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173026000121 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173026000122 active site 1173026000123 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173026000124 ABC1 family; Region: ABC1; cl17513 1173026000125 ABC1 family; Region: ABC1; cl17513 1173026000126 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1173026000127 DHH family; Region: DHH; pfam01368 1173026000128 FOG: CBS domain [General function prediction only]; Region: COG0517 1173026000129 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1173026000130 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173026000131 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173026000132 active site 1173026000133 NTP binding site [chemical binding]; other site 1173026000134 metal binding triad [ion binding]; metal-binding site 1173026000135 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1173026000136 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1173026000137 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 1173026000138 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1173026000139 homopentamer interface [polypeptide binding]; other site 1173026000140 active site 1173026000141 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173026000142 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173026000143 putative catalytic cysteine [active] 1173026000144 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173026000145 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173026000146 Di-iron ligands [ion binding]; other site 1173026000147 Aluminium resistance protein; Region: Alum_res; pfam06838 1173026000148 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1173026000149 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1173026000150 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026000151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026000152 S-adenosylmethionine binding site [chemical binding]; other site 1173026000153 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1173026000154 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026000155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000156 AMIN domain; Region: AMIN; pfam11741 1173026000157 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173026000158 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000159 N-terminal plug; other site 1173026000160 ligand-binding site [chemical binding]; other site 1173026000161 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000162 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000163 siderophore binding site; other site 1173026000164 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000165 putative active site [active] 1173026000166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026000167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000168 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000169 putative active site [active] 1173026000170 AMIN domain; Region: AMIN; pfam11741 1173026000171 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173026000172 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000173 N-terminal plug; other site 1173026000174 ligand-binding site [chemical binding]; other site 1173026000175 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1173026000176 putative dimer interface [polypeptide binding]; other site 1173026000177 putative [2Fe-2S] cluster binding site [ion binding]; other site 1173026000178 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000179 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000180 siderophore binding site; other site 1173026000181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026000182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000183 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026000184 active site 1173026000185 NTP binding site [chemical binding]; other site 1173026000186 metal binding triad [ion binding]; metal-binding site 1173026000187 antibiotic binding site [chemical binding]; other site 1173026000188 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1173026000189 AMIN domain; Region: AMIN; pfam11741 1173026000190 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173026000191 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000192 N-terminal plug; other site 1173026000193 ligand-binding site [chemical binding]; other site 1173026000194 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173026000195 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173026000196 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000197 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000198 siderophore binding site; other site 1173026000199 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1173026000200 putative dimer interface [polypeptide binding]; other site 1173026000201 putative [2Fe-2S] cluster binding site [ion binding]; other site 1173026000202 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026000203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000204 AMIN domain; Region: AMIN; pfam11741 1173026000205 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173026000206 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000207 N-terminal plug; other site 1173026000208 ligand-binding site [chemical binding]; other site 1173026000209 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000210 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000211 siderophore binding site; other site 1173026000212 CAAX protease self-immunity; Region: Abi; pfam02517 1173026000213 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 1173026000214 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026000215 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026000216 catalytic loop [active] 1173026000217 iron binding site [ion binding]; other site 1173026000218 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1173026000219 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1173026000220 substrate binding site [chemical binding]; other site 1173026000221 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1173026000222 substrate binding site [chemical binding]; other site 1173026000223 ligand binding site [chemical binding]; other site 1173026000224 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173026000225 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173026000226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000227 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026000228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000229 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1173026000230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026000231 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1173026000232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026000233 DNA binding residues [nucleotide binding] 1173026000234 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1173026000235 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173026000236 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173026000237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026000238 dimerization interface [polypeptide binding]; other site 1173026000239 putative DNA binding site [nucleotide binding]; other site 1173026000240 putative Zn2+ binding site [ion binding]; other site 1173026000241 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1173026000242 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026000243 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026000244 protein binding site [polypeptide binding]; other site 1173026000245 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1173026000246 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 1173026000247 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173026000248 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 1173026000249 NADP binding site [chemical binding]; other site 1173026000250 homotetramer interface [polypeptide binding]; other site 1173026000251 homodimer interface [polypeptide binding]; other site 1173026000252 active site 1173026000253 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1173026000254 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173026000255 active site 1173026000256 interdomain interaction site; other site 1173026000257 putative metal-binding site [ion binding]; other site 1173026000258 nucleotide binding site [chemical binding]; other site 1173026000259 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1173026000260 domain I; other site 1173026000261 phosphate binding site [ion binding]; other site 1173026000262 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173026000263 domain II; other site 1173026000264 domain III; other site 1173026000265 nucleotide binding site [chemical binding]; other site 1173026000266 DNA binding groove [nucleotide binding] 1173026000267 catalytic site [active] 1173026000268 domain IV; other site 1173026000269 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173026000270 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173026000271 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1173026000272 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1173026000273 putative active site [active] 1173026000274 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026000275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000276 AMIN domain; Region: AMIN; pfam11741 1173026000277 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026000278 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000279 N-terminal plug; other site 1173026000280 ligand-binding site [chemical binding]; other site 1173026000281 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000282 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000283 siderophore binding site; other site 1173026000284 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 1173026000285 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026000286 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 1173026000287 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1173026000288 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1173026000289 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1173026000290 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1173026000291 active site 1173026000292 SAM binding site [chemical binding]; other site 1173026000293 homodimer interface [polypeptide binding]; other site 1173026000294 Membrane protein of unknown function; Region: DUF360; pfam04020 1173026000295 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026000296 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000297 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026000298 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000299 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1173026000300 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1173026000301 NAD binding site [chemical binding]; other site 1173026000302 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173026000303 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026000304 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026000305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026000306 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026000307 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026000308 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026000309 putative oxidoreductase; Provisional; Region: PRK11579 1173026000310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026000311 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173026000312 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1173026000313 Na binding site [ion binding]; other site 1173026000314 S-layer homology domain; Region: SLH; pfam00395 1173026000315 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026000316 FG-GAP repeat; Region: FG-GAP; cl15299 1173026000317 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173026000318 D1 interface; other site 1173026000319 chlorophyll binding site; other site 1173026000320 pheophytin binding site; other site 1173026000321 beta carotene binding site; other site 1173026000322 cytochrome b559 beta interface; other site 1173026000323 quinone binding site; other site 1173026000324 cytochrome b559 alpha interface; other site 1173026000325 protein J interface; other site 1173026000326 protein H interface; other site 1173026000327 protein X interface; other site 1173026000328 core light harvesting protein interface; other site 1173026000329 protein L interface; other site 1173026000330 CP43 interface; other site 1173026000331 protein T interface; other site 1173026000332 Fe binding site [ion binding]; other site 1173026000333 protein M interface; other site 1173026000334 Mn-stabilizing polypeptide interface; other site 1173026000335 bromide binding site; other site 1173026000336 cytochrome c-550 interface; other site 1173026000337 hypothetical protein; Provisional; Region: PRK13683 1173026000338 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173026000339 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173026000340 Walker A/P-loop; other site 1173026000341 ATP binding site [chemical binding]; other site 1173026000342 Q-loop/lid; other site 1173026000343 ABC transporter signature motif; other site 1173026000344 Walker B; other site 1173026000345 D-loop; other site 1173026000346 H-loop/switch region; other site 1173026000347 YacP-like NYN domain; Region: NYN_YacP; cl01491 1173026000348 PRC-barrel domain; Region: PRC; pfam05239 1173026000349 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1173026000350 putative lipid kinase; Reviewed; Region: PRK00861 1173026000351 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173026000352 PEGA domain; Region: PEGA; pfam08308 1173026000353 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026000354 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026000355 active site 1173026000356 metal binding site [ion binding]; metal-binding site 1173026000357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1173026000358 FIST N domain; Region: FIST; pfam08495 1173026000359 FIST C domain; Region: FIST_C; pfam10442 1173026000360 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1173026000361 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1173026000362 active site 1173026000363 homodimer interface [polypeptide binding]; other site 1173026000364 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173026000365 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173026000366 Walker A motif; other site 1173026000367 ATP binding site [chemical binding]; other site 1173026000368 Walker B motif; other site 1173026000369 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173026000370 tetramer interface [polypeptide binding]; other site 1173026000371 dimer interface [polypeptide binding]; other site 1173026000372 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173026000373 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1173026000374 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1173026000375 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173026000376 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1173026000377 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173026000378 HIGH motif; other site 1173026000379 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173026000380 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1173026000381 active site 1173026000382 KMSKS motif; other site 1173026000383 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1173026000384 tRNA binding surface [nucleotide binding]; other site 1173026000385 anticodon binding site; other site 1173026000386 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173026000387 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173026000388 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173026000389 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026000390 P-loop; other site 1173026000391 Magnesium ion binding site [ion binding]; other site 1173026000392 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026000393 Magnesium ion binding site [ion binding]; other site 1173026000394 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1173026000395 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026000396 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1173026000397 AAA domain; Region: AAA_31; pfam13614 1173026000398 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026000399 P-loop; other site 1173026000400 Magnesium ion binding site [ion binding]; other site 1173026000401 ParA-like protein; Provisional; Region: PHA02518 1173026000402 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026000403 Magnesium ion binding site [ion binding]; other site 1173026000404 ParB-like nuclease domain; Region: ParBc; pfam02195 1173026000405 threonine synthase; Reviewed; Region: PRK06721 1173026000406 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173026000407 homodimer interface [polypeptide binding]; other site 1173026000408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026000409 catalytic residue [active] 1173026000410 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026000411 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173026000412 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1173026000413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026000414 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173026000415 EcoRII C terminal; Region: EcoRII-C; pfam09019 1173026000416 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173026000417 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1173026000418 cofactor binding site; other site 1173026000419 DNA binding site [nucleotide binding] 1173026000420 substrate interaction site [chemical binding]; other site 1173026000421 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1173026000422 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026000423 DXD motif; other site 1173026000424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026000425 putative substrate translocation pore; other site 1173026000426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026000427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026000428 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173026000429 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026000430 catalytic residues [active] 1173026000431 Electron transfer DM13; Region: DM13; pfam10517 1173026000432 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173026000433 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1173026000434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026000435 dimer interface [polypeptide binding]; other site 1173026000436 phosphorylation site [posttranslational modification] 1173026000437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000438 ATP binding site [chemical binding]; other site 1173026000439 Mg2+ binding site [ion binding]; other site 1173026000440 G-X-G motif; other site 1173026000441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026000442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000443 active site 1173026000444 phosphorylation site [posttranslational modification] 1173026000445 intermolecular recognition site; other site 1173026000446 dimerization interface [polypeptide binding]; other site 1173026000447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026000448 DNA binding site [nucleotide binding] 1173026000449 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 1173026000450 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1173026000451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173026000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026000453 dimer interface [polypeptide binding]; other site 1173026000454 conserved gate region; other site 1173026000455 putative PBP binding loops; other site 1173026000456 ABC-ATPase subunit interface; other site 1173026000457 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173026000458 dinuclear metal binding motif [ion binding]; other site 1173026000459 acyl-ACP reductase; Provisional; Region: PRK14982 1173026000460 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1173026000461 NAD(P) binding pocket [chemical binding]; other site 1173026000462 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1173026000463 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1173026000464 short chain dehydrogenase; Provisional; Region: PRK07454 1173026000465 classical (c) SDRs; Region: SDR_c; cd05233 1173026000466 NAD(P) binding site [chemical binding]; other site 1173026000467 active site 1173026000468 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1173026000469 homodecamer interface [polypeptide binding]; other site 1173026000470 GTP cyclohydrolase I; Provisional; Region: PLN03044 1173026000471 active site 1173026000472 putative catalytic site residues [active] 1173026000473 zinc binding site [ion binding]; other site 1173026000474 GTP-CH-I/GFRP interaction surface; other site 1173026000475 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1173026000476 active site 1173026000477 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 1173026000478 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1173026000479 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173026000480 active site 1173026000481 putative substrate binding region [chemical binding]; other site 1173026000482 FOG: CBS domain [General function prediction only]; Region: COG0517 1173026000483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1173026000484 putative lipid kinase; Reviewed; Region: PRK00861 1173026000485 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173026000486 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1173026000487 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173026000488 inhibitor-cofactor binding pocket; inhibition site 1173026000489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026000490 catalytic residue [active] 1173026000491 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 1173026000492 ATP adenylyltransferase; Region: ATP_transf; pfam09830 1173026000493 tyramine oxidase; Provisional; Region: tynA; PRK11504 1173026000494 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1173026000495 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1173026000496 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1173026000497 threonine synthase; Validated; Region: PRK07591 1173026000498 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1173026000499 homodimer interface [polypeptide binding]; other site 1173026000500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026000501 catalytic residue [active] 1173026000502 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173026000503 MoaE interaction surface [polypeptide binding]; other site 1173026000504 MoeB interaction surface [polypeptide binding]; other site 1173026000505 thiocarboxylated glycine; other site 1173026000506 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 1173026000507 TM2 domain; Region: TM2; cl00984 1173026000508 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1173026000509 diiron binding motif [ion binding]; other site 1173026000510 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1173026000511 Sulfatase; Region: Sulfatase; pfam00884 1173026000512 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1173026000513 oligomerisation interface [polypeptide binding]; other site 1173026000514 mobile loop; other site 1173026000515 roof hairpin; other site 1173026000516 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173026000517 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173026000518 ring oligomerisation interface [polypeptide binding]; other site 1173026000519 ATP/Mg binding site [chemical binding]; other site 1173026000520 stacking interactions; other site 1173026000521 hinge regions; other site 1173026000522 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026000523 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000524 AMIN domain; Region: AMIN; pfam11741 1173026000525 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026000526 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000527 N-terminal plug; other site 1173026000528 ligand-binding site [chemical binding]; other site 1173026000529 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026000530 active site 1173026000531 NTP binding site [chemical binding]; other site 1173026000532 metal binding triad [ion binding]; metal-binding site 1173026000533 antibiotic binding site [chemical binding]; other site 1173026000534 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000535 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000536 siderophore binding site; other site 1173026000537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026000539 S-adenosylmethionine binding site [chemical binding]; other site 1173026000540 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173026000541 Cytochrome P450; Region: p450; pfam00067 1173026000542 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1173026000543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000544 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026000545 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000546 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1173026000547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026000548 dimer interface [polypeptide binding]; other site 1173026000549 putative metal binding site [ion binding]; other site 1173026000550 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173026000551 Resolvase, N terminal domain; Region: Resolvase; smart00857 1173026000552 catalytic residues [active] 1173026000553 Recombinase; Region: Recombinase; pfam07508 1173026000554 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1173026000555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026000556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026000557 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173026000558 Walker A/P-loop; other site 1173026000559 ATP binding site [chemical binding]; other site 1173026000560 Q-loop/lid; other site 1173026000561 ABC transporter signature motif; other site 1173026000562 Walker B; other site 1173026000563 D-loop; other site 1173026000564 H-loop/switch region; other site 1173026000565 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026000566 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000567 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000568 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000569 siderophore binding site; other site 1173026000570 AMIN domain; Region: AMIN; pfam11741 1173026000571 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026000572 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000573 N-terminal plug; other site 1173026000574 ligand-binding site [chemical binding]; other site 1173026000575 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026000576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000577 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1173026000578 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1173026000579 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173026000580 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173026000581 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173026000582 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1173026000583 Cl- selectivity filter; other site 1173026000584 Cl- binding residues [ion binding]; other site 1173026000585 pore gating glutamate residue; other site 1173026000586 dimer interface [polypeptide binding]; other site 1173026000587 FOG: CBS domain [General function prediction only]; Region: COG0517 1173026000588 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 1173026000589 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173026000590 Rrf2 family protein; Region: rrf2_super; TIGR00738 1173026000591 Transcriptional regulator; Region: Rrf2; pfam02082 1173026000592 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1173026000593 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1173026000594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026000595 active site 1173026000596 PAS domain S-box; Region: sensory_box; TIGR00229 1173026000597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026000598 putative active site [active] 1173026000599 heme pocket [chemical binding]; other site 1173026000600 PAS domain; Region: PAS; smart00091 1173026000601 PAS domain; Region: PAS_9; pfam13426 1173026000602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026000603 putative active site [active] 1173026000604 heme pocket [chemical binding]; other site 1173026000605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026000606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026000607 dimer interface [polypeptide binding]; other site 1173026000608 phosphorylation site [posttranslational modification] 1173026000609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000610 ATP binding site [chemical binding]; other site 1173026000611 Mg2+ binding site [ion binding]; other site 1173026000612 G-X-G motif; other site 1173026000613 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026000614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000615 active site 1173026000616 phosphorylation site [posttranslational modification] 1173026000617 intermolecular recognition site; other site 1173026000618 dimerization interface [polypeptide binding]; other site 1173026000619 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1173026000620 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1173026000621 homotetramer interface [polypeptide binding]; other site 1173026000622 FMN binding site [chemical binding]; other site 1173026000623 homodimer contacts [polypeptide binding]; other site 1173026000624 putative active site [active] 1173026000625 putative substrate binding site [chemical binding]; other site 1173026000626 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173026000627 ligand-binding site [chemical binding]; other site 1173026000628 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1173026000629 Ion channel; Region: Ion_trans_2; pfam07885 1173026000630 Double zinc ribbon; Region: DZR; pfam12773 1173026000631 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1173026000632 nucleoside/Zn binding site; other site 1173026000633 dimer interface [polypeptide binding]; other site 1173026000634 catalytic motif [active] 1173026000635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026000636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000637 active site 1173026000638 phosphorylation site [posttranslational modification] 1173026000639 intermolecular recognition site; other site 1173026000640 dimerization interface [polypeptide binding]; other site 1173026000641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026000642 DNA binding residues [nucleotide binding] 1173026000643 dimerization interface [polypeptide binding]; other site 1173026000644 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173026000645 Histidine kinase; Region: HisKA_3; pfam07730 1173026000646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000647 ATP binding site [chemical binding]; other site 1173026000648 Mg2+ binding site [ion binding]; other site 1173026000649 G-X-G motif; other site 1173026000650 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173026000651 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173026000652 putative active site [active] 1173026000653 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1173026000654 putative active site [active] 1173026000655 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 1173026000656 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173026000657 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026000658 catalytic triad [active] 1173026000659 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173026000660 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173026000661 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1173026000662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026000663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000664 active site 1173026000665 phosphorylation site [posttranslational modification] 1173026000666 intermolecular recognition site; other site 1173026000667 dimerization interface [polypeptide binding]; other site 1173026000668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026000669 DNA binding site [nucleotide binding] 1173026000670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026000671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026000672 dimerization interface [polypeptide binding]; other site 1173026000673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026000674 dimer interface [polypeptide binding]; other site 1173026000675 phosphorylation site [posttranslational modification] 1173026000676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000677 ATP binding site [chemical binding]; other site 1173026000678 Mg2+ binding site [ion binding]; other site 1173026000679 G-X-G motif; other site 1173026000680 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1173026000681 Ligand Binding Site [chemical binding]; other site 1173026000682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173026000683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026000684 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1173026000685 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 1173026000686 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1173026000687 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173026000688 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173026000689 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173026000690 putative lipid kinase; Reviewed; Region: PRK13057 1173026000691 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1173026000692 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1173026000693 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026000694 Ligand Binding Site [chemical binding]; other site 1173026000695 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1173026000696 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1173026000697 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173026000698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026000699 NAD(P) binding site [chemical binding]; other site 1173026000700 active site 1173026000701 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 1173026000702 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173026000703 RNA binding surface [nucleotide binding]; other site 1173026000704 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1173026000705 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1173026000706 ligand binding site [chemical binding]; other site 1173026000707 NAD binding site [chemical binding]; other site 1173026000708 dimerization interface [polypeptide binding]; other site 1173026000709 catalytic site [active] 1173026000710 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1173026000711 putative L-serine binding site [chemical binding]; other site 1173026000712 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1173026000713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026000714 S-adenosylmethionine binding site [chemical binding]; other site 1173026000715 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173026000716 catalytic residues [active] 1173026000717 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173026000718 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1173026000719 NAD(P) binding site [chemical binding]; other site 1173026000720 homotetramer interface [polypeptide binding]; other site 1173026000721 homodimer interface [polypeptide binding]; other site 1173026000722 active site 1173026000723 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173026000724 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1173026000725 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1173026000726 ring oligomerisation interface [polypeptide binding]; other site 1173026000727 ATP/Mg binding site [chemical binding]; other site 1173026000728 stacking interactions; other site 1173026000729 hinge regions; other site 1173026000730 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1173026000731 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1173026000732 oligomer interface [polypeptide binding]; other site 1173026000733 metal binding site [ion binding]; metal-binding site 1173026000734 metal binding site [ion binding]; metal-binding site 1173026000735 Cl binding site [ion binding]; other site 1173026000736 aspartate ring; other site 1173026000737 basic sphincter; other site 1173026000738 putative hydrophobic gate; other site 1173026000739 periplasmic entrance; other site 1173026000740 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 1173026000741 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1173026000742 dimerization interface [polypeptide binding]; other site 1173026000743 active site 1173026000744 metal binding site [ion binding]; metal-binding site 1173026000745 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1173026000746 dsRNA binding site [nucleotide binding]; other site 1173026000747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026000748 HAMP domain; Region: HAMP; pfam00672 1173026000749 dimerization interface [polypeptide binding]; other site 1173026000750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026000751 dimer interface [polypeptide binding]; other site 1173026000752 phosphorylation site [posttranslational modification] 1173026000753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000754 ATP binding site [chemical binding]; other site 1173026000755 Mg2+ binding site [ion binding]; other site 1173026000756 G-X-G motif; other site 1173026000757 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1173026000758 RibD C-terminal domain; Region: RibD_C; cl17279 1173026000759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1173026000760 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1173026000761 TPR repeat; Region: TPR_11; pfam13414 1173026000762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026000763 binding surface 1173026000764 TPR motif; other site 1173026000765 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000766 putative active site [active] 1173026000767 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 1173026000768 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1173026000769 Repair protein; Region: Repair_PSII; pfam04536 1173026000770 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173026000771 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026000772 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026000773 ligand binding site [chemical binding]; other site 1173026000774 flexible hinge region; other site 1173026000775 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026000776 putative switch regulator; other site 1173026000777 non-specific DNA interactions [nucleotide binding]; other site 1173026000778 DNA binding site [nucleotide binding] 1173026000779 sequence specific DNA binding site [nucleotide binding]; other site 1173026000780 putative cAMP binding site [chemical binding]; other site 1173026000781 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1173026000782 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1173026000783 putative dimer interface [polypeptide binding]; other site 1173026000784 active site pocket [active] 1173026000785 CpeS-like protein; Region: CpeS; pfam09367 1173026000786 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1173026000787 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173026000788 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1173026000789 RNA polymerase sigma factor; Provisional; Region: PRK12519 1173026000790 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026000791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026000792 DNA binding residues [nucleotide binding] 1173026000793 putative anti-sigmaE protein; Provisional; Region: PRK13920 1173026000794 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173026000795 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173026000796 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173026000797 Transporter associated domain; Region: CorC_HlyC; smart01091 1173026000798 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026000799 active site 1173026000800 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1173026000801 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1173026000802 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1173026000803 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173026000804 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026000805 putative binding surface; other site 1173026000806 active site 1173026000807 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173026000808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000809 ATP binding site [chemical binding]; other site 1173026000810 Mg2+ binding site [ion binding]; other site 1173026000811 G-X-G motif; other site 1173026000812 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1173026000813 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026000814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000815 active site 1173026000816 phosphorylation site [posttranslational modification] 1173026000817 intermolecular recognition site; other site 1173026000818 dimerization interface [polypeptide binding]; other site 1173026000819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026000820 dimerization interface [polypeptide binding]; other site 1173026000821 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026000822 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026000823 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173026000824 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173026000825 dimer interface [polypeptide binding]; other site 1173026000826 putative CheW interface [polypeptide binding]; other site 1173026000827 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173026000828 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000830 active site 1173026000831 phosphorylation site [posttranslational modification] 1173026000832 intermolecular recognition site; other site 1173026000833 dimerization interface [polypeptide binding]; other site 1173026000834 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026000835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026000836 active site 1173026000837 phosphorylation site [posttranslational modification] 1173026000838 intermolecular recognition site; other site 1173026000839 dimerization interface [polypeptide binding]; other site 1173026000840 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1173026000841 active site 1173026000842 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1173026000843 TPR repeat; Region: TPR_11; pfam13414 1173026000844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026000845 binding surface 1173026000846 TPR motif; other site 1173026000847 TPR repeat; Region: TPR_11; pfam13414 1173026000848 Tetratricopeptide repeat; Region: TPR_1; pfam00515 1173026000849 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026000850 TPR motif; other site 1173026000851 binding surface 1173026000852 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173026000853 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026000854 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000855 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000856 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173026000857 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173026000858 Ligand binding site; other site 1173026000859 Putative Catalytic site; other site 1173026000860 DXD motif; other site 1173026000861 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173026000862 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173026000863 Di-iron ligands [ion binding]; other site 1173026000864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026000865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026000866 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026000867 active site 1173026000868 Int/Topo IB signature motif; other site 1173026000869 DNA binding site [nucleotide binding] 1173026000870 AMIN domain; Region: AMIN; pfam11741 1173026000871 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1173026000872 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026000873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000874 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173026000875 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026000876 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026000877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026000878 catalytic loop [active] 1173026000879 iron binding site [ion binding]; other site 1173026000880 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 1173026000881 Stage II sporulation protein; Region: SpoIID; pfam08486 1173026000882 ParB-like nuclease domain; Region: ParBc; cl02129 1173026000883 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173026000884 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173026000885 dimerization interface [polypeptide binding]; other site 1173026000886 DPS ferroxidase diiron center [ion binding]; other site 1173026000887 ion pore; other site 1173026000888 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1173026000889 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173026000890 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173026000891 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173026000892 dimerization interface [polypeptide binding]; other site 1173026000893 DPS ferroxidase diiron center [ion binding]; other site 1173026000894 ion pore; other site 1173026000895 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1173026000896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026000897 binding surface 1173026000898 TPR motif; other site 1173026000899 TPR repeat; Region: TPR_11; pfam13414 1173026000900 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000901 putative active site [active] 1173026000902 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173026000903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173026000904 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1173026000905 aromatic arch; other site 1173026000906 DCoH dimer interaction site [polypeptide binding]; other site 1173026000907 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1173026000908 DCoH tetramer interaction site [polypeptide binding]; other site 1173026000909 substrate binding site [chemical binding]; other site 1173026000910 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026000911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026000912 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000913 putative active site [active] 1173026000914 AMIN domain; Region: AMIN; pfam11741 1173026000915 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026000916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026000917 N-terminal plug; other site 1173026000918 ligand-binding site [chemical binding]; other site 1173026000919 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026000920 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026000921 siderophore binding site; other site 1173026000922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026000923 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000924 putative active site [active] 1173026000925 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173026000926 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1173026000927 active site 1173026000928 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026000929 putative active site [active] 1173026000930 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1173026000931 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173026000932 substrate binding site [chemical binding]; other site 1173026000933 ATP binding site [chemical binding]; other site 1173026000934 S-layer homology domain; Region: SLH; pfam00395 1173026000935 S-layer homology domain; Region: SLH; pfam00395 1173026000936 S-layer homology domain; Region: SLH; pfam00395 1173026000937 Predicted methyltransferases [General function prediction only]; Region: COG0313 1173026000938 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1173026000939 putative SAM binding site [chemical binding]; other site 1173026000940 putative homodimer interface [polypeptide binding]; other site 1173026000941 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173026000942 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173026000943 active site 1173026000944 substrate binding site [chemical binding]; other site 1173026000945 metal binding site [ion binding]; metal-binding site 1173026000946 Predicted membrane protein [Function unknown]; Region: COG3431 1173026000947 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1173026000948 DNA polymerase I; Provisional; Region: PRK05755 1173026000949 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1173026000950 active site 1173026000951 metal binding site 1 [ion binding]; metal-binding site 1173026000952 putative 5' ssDNA interaction site; other site 1173026000953 metal binding site 3; metal-binding site 1173026000954 metal binding site 2 [ion binding]; metal-binding site 1173026000955 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1173026000956 putative DNA binding site [nucleotide binding]; other site 1173026000957 putative metal binding site [ion binding]; other site 1173026000958 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1173026000959 active site 1173026000960 catalytic site [active] 1173026000961 substrate binding site [chemical binding]; other site 1173026000962 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1173026000963 active site 1173026000964 DNA binding site [nucleotide binding] 1173026000965 catalytic site [active] 1173026000966 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1173026000967 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1173026000968 transmembrane helices; other site 1173026000969 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1173026000970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026000971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026000972 dimer interface [polypeptide binding]; other site 1173026000973 phosphorylation site [posttranslational modification] 1173026000974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026000975 ATP binding site [chemical binding]; other site 1173026000976 Mg2+ binding site [ion binding]; other site 1173026000977 G-X-G motif; other site 1173026000978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026000979 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 1173026000980 Walker A motif; other site 1173026000981 ATP binding site [chemical binding]; other site 1173026000982 Walker B motif; other site 1173026000983 arginine finger; other site 1173026000984 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1173026000985 metal ion-dependent adhesion site (MIDAS); other site 1173026000986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026000987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173026000988 Coenzyme A binding pocket [chemical binding]; other site 1173026000989 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000990 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026000991 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000993 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000994 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000995 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026000996 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173026000997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026000998 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026000999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026001000 DNA binding residues [nucleotide binding] 1173026001001 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 1173026001002 metal-binding heat shock protein; Provisional; Region: PRK00016 1173026001003 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1173026001004 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1173026001005 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1173026001006 glutamine binding [chemical binding]; other site 1173026001007 catalytic triad [active] 1173026001008 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173026001009 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1173026001010 proline aminopeptidase P II; Provisional; Region: PRK10879 1173026001011 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1173026001012 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173026001013 active site 1173026001014 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026001015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026001016 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026001017 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173026001018 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173026001019 B12 binding site [chemical binding]; other site 1173026001020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026001021 FeS/SAM binding site; other site 1173026001022 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1173026001023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026001024 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1173026001025 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1173026001026 Tetramer interface [polypeptide binding]; other site 1173026001027 active site 1173026001028 FMN-binding site [chemical binding]; other site 1173026001029 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1173026001030 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1173026001031 cell division protein FtsZ; Validated; Region: PRK09330 1173026001032 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1173026001033 nucleotide binding site [chemical binding]; other site 1173026001034 SulA interaction site; other site 1173026001035 glutathione synthetase; Provisional; Region: PRK05246 1173026001036 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1173026001037 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1173026001038 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173026001039 GSH binding site [chemical binding]; other site 1173026001040 catalytic residues [active] 1173026001041 GTPase RsgA; Reviewed; Region: PRK12289 1173026001042 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1173026001043 RNA binding site [nucleotide binding]; other site 1173026001044 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1173026001045 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1173026001046 GTP/Mg2+ binding site [chemical binding]; other site 1173026001047 G4 box; other site 1173026001048 G5 box; other site 1173026001049 G1 box; other site 1173026001050 Switch I region; other site 1173026001051 G2 box; other site 1173026001052 G3 box; other site 1173026001053 Switch II region; other site 1173026001054 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1173026001055 CPxP motif; other site 1173026001056 chaperone protein DnaJ; Provisional; Region: PRK14293 1173026001057 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026001058 HSP70 interaction site [polypeptide binding]; other site 1173026001059 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1173026001060 substrate binding site [polypeptide binding]; other site 1173026001061 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1173026001062 Zn binding sites [ion binding]; other site 1173026001063 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173026001064 dimer interface [polypeptide binding]; other site 1173026001065 molecular chaperone DnaK; Provisional; Region: PRK13411 1173026001066 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173026001067 nucleotide binding site [chemical binding]; other site 1173026001068 NEF interaction site [polypeptide binding]; other site 1173026001069 SBD interface [polypeptide binding]; other site 1173026001070 GrpE; Region: GrpE; pfam01025 1173026001071 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1173026001072 dimer interface [polypeptide binding]; other site 1173026001073 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1173026001074 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1173026001075 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173026001076 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173026001077 Walker A motif; other site 1173026001078 ATP binding site [chemical binding]; other site 1173026001079 Walker B motif; other site 1173026001080 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1173026001081 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1173026001082 Walker A motif; other site 1173026001083 ATP binding site [chemical binding]; other site 1173026001084 Walker B motif; other site 1173026001085 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1173026001086 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173026001087 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1173026001088 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026001089 FG-GAP repeat; Region: FG-GAP; cl15299 1173026001090 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026001091 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173026001092 biotin synthase; Validated; Region: PRK06256 1173026001093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026001094 FeS/SAM binding site; other site 1173026001095 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1173026001096 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1173026001097 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173026001098 inhibitor-cofactor binding pocket; inhibition site 1173026001099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026001100 catalytic residue [active] 1173026001101 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1173026001102 Ycf35; Provisional; Region: ycf35; CHL00193 1173026001103 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1173026001104 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173026001105 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173026001106 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1173026001107 MutS domain III; Region: MutS_III; pfam05192 1173026001108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026001109 Walker A/P-loop; other site 1173026001110 ATP binding site [chemical binding]; other site 1173026001111 Q-loop/lid; other site 1173026001112 ABC transporter signature motif; other site 1173026001113 Walker B; other site 1173026001114 D-loop; other site 1173026001115 H-loop/switch region; other site 1173026001116 Smr domain; Region: Smr; pfam01713 1173026001117 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1173026001118 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1173026001119 active site 1173026001120 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173026001121 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026001122 catalytic residues [active] 1173026001123 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1173026001124 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 1173026001125 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026001126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026001127 active site 1173026001128 phosphorylation site [posttranslational modification] 1173026001129 intermolecular recognition site; other site 1173026001130 dimerization interface [polypeptide binding]; other site 1173026001131 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173026001132 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173026001133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026001134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026001135 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026001136 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026001137 acetyl-CoA synthetase; Provisional; Region: PRK00174 1173026001138 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1173026001139 active site 1173026001140 CoA binding site [chemical binding]; other site 1173026001141 acyl-activating enzyme (AAE) consensus motif; other site 1173026001142 AMP binding site [chemical binding]; other site 1173026001143 acetate binding site [chemical binding]; other site 1173026001144 Integral membrane protein TerC family; Region: TerC; pfam03741 1173026001145 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1173026001146 active site 1173026001147 multimer interface [polypeptide binding]; other site 1173026001148 arginine decarboxylase; Provisional; Region: PRK05354 1173026001149 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1173026001150 dimer interface [polypeptide binding]; other site 1173026001151 active site 1173026001152 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173026001153 catalytic residues [active] 1173026001154 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1173026001155 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173026001156 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173026001157 active site 1173026001158 Substrate binding site; other site 1173026001159 Mg++ binding site; other site 1173026001160 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 1173026001161 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173026001162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173026001163 Homeodomain-like domain; Region: HTH_23; pfam13384 1173026001164 Winged helix-turn helix; Region: HTH_29; pfam13551 1173026001165 Homeodomain-like domain; Region: HTH_32; pfam13565 1173026001166 ScpA/B protein; Region: ScpA_ScpB; cl00598 1173026001167 ScpA/B protein; Region: ScpA_ScpB; cl00598 1173026001168 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1173026001169 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173026001170 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1173026001171 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1173026001172 TPR repeat; Region: TPR_11; pfam13414 1173026001173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026001174 binding surface 1173026001175 TPR motif; other site 1173026001176 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1173026001177 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173026001178 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173026001179 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1173026001180 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173026001181 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173026001182 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173026001183 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1173026001184 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1173026001185 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1173026001186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026001187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026001188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173026001189 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173026001190 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173026001191 iron-sulfur cluster [ion binding]; other site 1173026001192 [2Fe-2S] cluster binding site [ion binding]; other site 1173026001193 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173026001194 active site 1173026001195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026001196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026001197 integron integrase; Region: integrase_gron; TIGR02249 1173026001198 Penicillin amidase; Region: Penicil_amidase; pfam01804 1173026001199 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1173026001200 active site 1173026001201 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1173026001202 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173026001203 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173026001204 Walker A/P-loop; other site 1173026001205 ATP binding site [chemical binding]; other site 1173026001206 Q-loop/lid; other site 1173026001207 ABC transporter signature motif; other site 1173026001208 Walker B; other site 1173026001209 D-loop; other site 1173026001210 H-loop/switch region; other site 1173026001211 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173026001212 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1173026001213 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026001214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026001215 active site 1173026001216 metal binding site [ion binding]; metal-binding site 1173026001217 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1173026001218 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026001219 GAF domain; Region: GAF; pfam01590 1173026001220 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026001221 GAF domain; Region: GAF; pfam01590 1173026001222 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026001223 GAF domain; Region: GAF; pfam01590 1173026001224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026001225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026001226 dimer interface [polypeptide binding]; other site 1173026001227 phosphorylation site [posttranslational modification] 1173026001228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026001229 ATP binding site [chemical binding]; other site 1173026001230 Mg2+ binding site [ion binding]; other site 1173026001231 G-X-G motif; other site 1173026001232 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026001233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026001234 active site 1173026001235 phosphorylation site [posttranslational modification] 1173026001236 intermolecular recognition site; other site 1173026001237 dimerization interface [polypeptide binding]; other site 1173026001238 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173026001239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026001240 active site 1173026001241 catalytic tetrad [active] 1173026001242 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1173026001243 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1173026001244 Lumazine binding domain; Region: Lum_binding; pfam00677 1173026001245 Lumazine binding domain; Region: Lum_binding; pfam00677 1173026001246 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1173026001247 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1173026001248 active site 1173026001249 Zn binding site [ion binding]; other site 1173026001250 sucrose synthase; Region: sucr_synth; TIGR02470 1173026001251 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173026001252 putative ADP-binding pocket [chemical binding]; other site 1173026001253 calcium/proton exchanger (cax); Region: cax; TIGR00378 1173026001254 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173026001255 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1173026001256 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 1173026001257 active site 1173026001258 catalytic site [active] 1173026001259 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 1173026001260 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173026001261 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173026001262 active site 1173026001263 KGK domain; Region: KGK; pfam08872 1173026001264 KGK domain; Region: KGK; pfam08872 1173026001265 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1173026001266 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173026001267 G1 box; other site 1173026001268 GTP/Mg2+ binding site [chemical binding]; other site 1173026001269 G2 box; other site 1173026001270 Switch I region; other site 1173026001271 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173026001272 G3 box; other site 1173026001273 Switch II region; other site 1173026001274 G4 box; other site 1173026001275 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1173026001276 trimer interface [polypeptide binding]; other site 1173026001277 putative Zn binding site [ion binding]; other site 1173026001278 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1173026001279 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1173026001280 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1173026001281 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1173026001282 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026001283 GTPase Era; Reviewed; Region: era; PRK00089 1173026001284 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1173026001285 G1 box; other site 1173026001286 GTP/Mg2+ binding site [chemical binding]; other site 1173026001287 Switch I region; other site 1173026001288 G2 box; other site 1173026001289 Switch II region; other site 1173026001290 G3 box; other site 1173026001291 G4 box; other site 1173026001292 G5 box; other site 1173026001293 KH domain; Region: KH_2; pfam07650 1173026001294 6-phosphofructokinase; Provisional; Region: PRK14071 1173026001295 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1173026001296 active site 1173026001297 ADP/pyrophosphate binding site [chemical binding]; other site 1173026001298 dimerization interface [polypeptide binding]; other site 1173026001299 allosteric effector site; other site 1173026001300 fructose-1,6-bisphosphate binding site; other site 1173026001301 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1173026001302 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1173026001303 active site 1173026001304 Zn binding site [ion binding]; other site 1173026001305 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173026001306 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1173026001307 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1173026001308 active site 1173026001309 dimer interface [polypeptide binding]; other site 1173026001310 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173026001311 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026001312 catalytic core [active] 1173026001313 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1173026001314 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173026001315 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026001316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026001317 putative active site [active] 1173026001318 heme pocket [chemical binding]; other site 1173026001319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026001320 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1173026001321 putative active site [active] 1173026001322 heme pocket [chemical binding]; other site 1173026001323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026001324 putative active site [active] 1173026001325 heme pocket [chemical binding]; other site 1173026001326 PAS domain; Region: PAS; smart00091 1173026001327 putative active site [active] 1173026001328 heme pocket [chemical binding]; other site 1173026001329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026001330 metal binding site [ion binding]; metal-binding site 1173026001331 active site 1173026001332 I-site; other site 1173026001333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026001334 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 1173026001335 malate dehydrogenase; Reviewed; Region: PRK06223 1173026001336 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1173026001337 NAD(P) binding site [chemical binding]; other site 1173026001338 dimer interface [polypeptide binding]; other site 1173026001339 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173026001340 substrate binding site [chemical binding]; other site 1173026001341 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 1173026001342 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1173026001343 DNA binding site [nucleotide binding] 1173026001344 catalytic residue [active] 1173026001345 H2TH interface [polypeptide binding]; other site 1173026001346 putative catalytic residues [active] 1173026001347 turnover-facilitating residue; other site 1173026001348 intercalation triad [nucleotide binding]; other site 1173026001349 8OG recognition residue [nucleotide binding]; other site 1173026001350 putative reading head residues; other site 1173026001351 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1173026001352 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1173026001353 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; pfam02427 1173026001354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026001355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026001356 DNA binding residues [nucleotide binding] 1173026001357 dimerization interface [polypeptide binding]; other site 1173026001358 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1173026001359 catalytic motif [active] 1173026001360 Catalytic residue [active] 1173026001361 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1173026001362 catalytic motif [active] 1173026001363 Catalytic residue [active] 1173026001364 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1173026001365 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173026001366 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173026001367 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173026001368 RNA binding site [nucleotide binding]; other site 1173026001369 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173026001370 RNA binding site [nucleotide binding]; other site 1173026001371 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1173026001372 RNA binding site [nucleotide binding]; other site 1173026001373 Dienelactone hydrolase family; Region: DLH; pfam01738 1173026001374 Predicted transcriptional regulators [Transcription]; Region: COG1725 1173026001375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026001376 DNA-binding site [nucleotide binding]; DNA binding site 1173026001377 MarC family integral membrane protein; Region: MarC; pfam01914 1173026001378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026001379 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026001380 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1173026001381 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1173026001382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026001383 Walker A motif; other site 1173026001384 ATP binding site [chemical binding]; other site 1173026001385 Walker B motif; other site 1173026001386 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1173026001387 Clp protease; Region: CLP_protease; pfam00574 1173026001388 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173026001389 oligomer interface [polypeptide binding]; other site 1173026001390 active site residues [active] 1173026001391 trigger factor; Provisional; Region: tig; PRK01490 1173026001392 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173026001393 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1173026001394 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1173026001395 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173026001396 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1173026001397 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1173026001398 dimer interface [polypeptide binding]; other site 1173026001399 active site 1173026001400 catalytic residue [active] 1173026001401 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1173026001402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173026001403 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173026001404 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173026001405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026001406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026001407 active site 1173026001408 catalytic tetrad [active] 1173026001409 ribosomal protein L32; Validated; Region: rpl32; CHL00152 1173026001410 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173026001411 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1173026001412 Moco binding site; other site 1173026001413 metal coordination site [ion binding]; other site 1173026001414 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1173026001415 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1173026001416 NAD(P) binding site [chemical binding]; other site 1173026001417 catalytic residues [active] 1173026001418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026001419 active site 1173026001420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026001421 phosphorylation site [posttranslational modification] 1173026001422 intermolecular recognition site; other site 1173026001423 dimerization interface [polypeptide binding]; other site 1173026001424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026001425 dimer interface [polypeptide binding]; other site 1173026001426 phosphorylation site [posttranslational modification] 1173026001427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026001428 ATP binding site [chemical binding]; other site 1173026001429 Mg2+ binding site [ion binding]; other site 1173026001430 G-X-G motif; other site 1173026001431 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1173026001432 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1173026001433 subunit interactions [polypeptide binding]; other site 1173026001434 active site 1173026001435 flap region; other site 1173026001436 TM2 domain; Region: TM2; cl00984 1173026001437 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026001438 non-specific DNA binding site [nucleotide binding]; other site 1173026001439 salt bridge; other site 1173026001440 sequence-specific DNA binding site [nucleotide binding]; other site 1173026001441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026001442 non-specific DNA binding site [nucleotide binding]; other site 1173026001443 salt bridge; other site 1173026001444 sequence-specific DNA binding site [nucleotide binding]; other site 1173026001445 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1173026001446 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1173026001447 G1 box; other site 1173026001448 putative GEF interaction site [polypeptide binding]; other site 1173026001449 GTP/Mg2+ binding site [chemical binding]; other site 1173026001450 Switch I region; other site 1173026001451 G2 box; other site 1173026001452 G3 box; other site 1173026001453 Switch II region; other site 1173026001454 G4 box; other site 1173026001455 G5 box; other site 1173026001456 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1173026001457 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1173026001458 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1173026001459 Protein of unknown function DUF58; Region: DUF58; pfam01882 1173026001460 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 1173026001461 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1173026001462 OstA-like protein; Region: OstA; cl00844 1173026001463 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1173026001464 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1173026001465 Walker A/P-loop; other site 1173026001466 ATP binding site [chemical binding]; other site 1173026001467 Q-loop/lid; other site 1173026001468 ABC transporter signature motif; other site 1173026001469 Walker B; other site 1173026001470 D-loop; other site 1173026001471 H-loop/switch region; other site 1173026001472 Predicted permeases [General function prediction only]; Region: COG0795 1173026001473 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1173026001474 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026001475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026001476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026001477 Walker A/P-loop; other site 1173026001478 ATP binding site [chemical binding]; other site 1173026001479 Q-loop/lid; other site 1173026001480 ABC transporter signature motif; other site 1173026001481 Walker B; other site 1173026001482 D-loop; other site 1173026001483 H-loop/switch region; other site 1173026001484 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173026001485 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173026001486 intersubunit interface [polypeptide binding]; other site 1173026001487 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173026001488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026001489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026001490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026001491 Walker A/P-loop; other site 1173026001492 ATP binding site [chemical binding]; other site 1173026001493 Q-loop/lid; other site 1173026001494 ABC transporter signature motif; other site 1173026001495 Walker B; other site 1173026001496 D-loop; other site 1173026001497 H-loop/switch region; other site 1173026001498 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026001499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026001500 AMIN domain; Region: AMIN; pfam11741 1173026001501 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026001502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026001503 N-terminal plug; other site 1173026001504 ligand-binding site [chemical binding]; other site 1173026001505 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1173026001506 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026001507 siderophore binding site; other site 1173026001508 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026001509 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173026001510 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026001511 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173026001512 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1173026001513 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1173026001514 putative active site [active] 1173026001515 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 1173026001516 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1173026001517 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1173026001518 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173026001519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1173026001520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026001521 putative PBP binding loops; other site 1173026001522 ABC-ATPase subunit interface; other site 1173026001523 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026001524 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173026001525 active site 1173026001526 ATP binding site [chemical binding]; other site 1173026001527 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173026001528 substrate binding site [chemical binding]; other site 1173026001529 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026001530 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026001531 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026001532 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1173026001533 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173026001534 Walker A/P-loop; other site 1173026001535 ATP binding site [chemical binding]; other site 1173026001536 Q-loop/lid; other site 1173026001537 ABC transporter signature motif; other site 1173026001538 Walker B; other site 1173026001539 D-loop; other site 1173026001540 H-loop/switch region; other site 1173026001541 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1173026001542 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173026001543 Walker A/P-loop; other site 1173026001544 ATP binding site [chemical binding]; other site 1173026001545 Q-loop/lid; other site 1173026001546 ABC transporter signature motif; other site 1173026001547 Walker B; other site 1173026001548 D-loop; other site 1173026001549 H-loop/switch region; other site 1173026001550 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1173026001551 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173026001552 TM-ABC transporter signature motif; other site 1173026001553 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173026001554 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173026001555 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173026001556 TM-ABC transporter signature motif; other site 1173026001557 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173026001558 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1173026001559 putative ligand binding site [chemical binding]; other site 1173026001560 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026001561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026001562 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026001563 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026001564 Isochorismatase family; Region: Isochorismatase; pfam00857 1173026001565 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173026001566 catalytic triad [active] 1173026001567 conserved cis-peptide bond; other site 1173026001568 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1173026001569 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1173026001570 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1173026001571 Walker A/P-loop; other site 1173026001572 ATP binding site [chemical binding]; other site 1173026001573 Q-loop/lid; other site 1173026001574 ABC transporter signature motif; other site 1173026001575 Walker B; other site 1173026001576 D-loop; other site 1173026001577 H-loop/switch region; other site 1173026001578 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1173026001579 Isochorismatase family; Region: Isochorismatase; pfam00857 1173026001580 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173026001581 catalytic triad [active] 1173026001582 conserved cis-peptide bond; other site 1173026001583 formamidase; Provisional; Region: amiF; PRK13287 1173026001584 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1173026001585 multimer interface [polypeptide binding]; other site 1173026001586 active site 1173026001587 catalytic triad [active] 1173026001588 dimer interface [polypeptide binding]; other site 1173026001589 allophanate hydrolase; Provisional; Region: PRK08186 1173026001590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173026001591 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1173026001592 TM-ABC transporter signature motif; other site 1173026001593 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173026001594 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1173026001595 TM-ABC transporter signature motif; other site 1173026001596 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1173026001597 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1173026001598 putative ligand binding site [chemical binding]; other site 1173026001599 AAA ATPase domain; Region: AAA_16; pfam13191 1173026001600 NACHT domain; Region: NACHT; pfam05729 1173026001601 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173026001602 WD domain, G-beta repeat; Region: WD40; pfam00400 1173026001603 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026001604 structural tetrad; other site 1173026001605 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026001606 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026001607 structural tetrad; other site 1173026001608 WD domain, G-beta repeat; Region: WD40; pfam00400 1173026001609 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173026001610 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1173026001611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1173026001612 ferrochelatase; Reviewed; Region: hemH; PRK00035 1173026001613 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173026001614 C-terminal domain interface [polypeptide binding]; other site 1173026001615 active site 1173026001616 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173026001617 active site 1173026001618 N-terminal domain interface [polypeptide binding]; other site 1173026001619 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504 1173026001620 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173026001621 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173026001622 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173026001623 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1173026001624 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1173026001625 O-methyltransferase; Region: Methyltransf_2; pfam00891 1173026001626 hypothetical protein; Provisional; Region: PRK06849 1173026001627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026001628 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173026001629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026001630 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1173026001631 active site 1173026001632 NAD binding site [chemical binding]; other site 1173026001633 metal binding site [ion binding]; metal-binding site 1173026001634 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1173026001635 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173026001636 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173026001637 homodimer interface [polypeptide binding]; other site 1173026001638 active site 1173026001639 TDP-binding site; other site 1173026001640 acceptor substrate-binding pocket; other site 1173026001641 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1173026001642 beta-galactosidase; Region: BGL; TIGR03356 1173026001643 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 1173026001644 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 1173026001645 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1173026001646 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173026001647 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1173026001648 active site 1173026001649 dimer interface [polypeptide binding]; other site 1173026001650 motif 1; other site 1173026001651 motif 2; other site 1173026001652 motif 3; other site 1173026001653 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1173026001654 anticodon binding site; other site 1173026001655 adenylosuccinate lyase; Provisional; Region: PRK07380 1173026001656 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1173026001657 tetramer interface [polypeptide binding]; other site 1173026001658 active site 1173026001659 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1173026001660 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1173026001661 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173026001662 NADP binding site [chemical binding]; other site 1173026001663 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173026001664 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173026001665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026001666 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173026001667 putative ADP-binding pocket [chemical binding]; other site 1173026001668 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173026001669 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026001670 GAF domain; Region: GAF; pfam01590 1173026001671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026001672 dimer interface [polypeptide binding]; other site 1173026001673 phosphorylation site [posttranslational modification] 1173026001674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026001675 ATP binding site [chemical binding]; other site 1173026001676 Mg2+ binding site [ion binding]; other site 1173026001677 G-X-G motif; other site 1173026001678 PsaD; Region: PsaD; pfam02531 1173026001679 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1173026001680 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173026001681 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173026001682 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173026001683 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026001684 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1173026001685 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1173026001686 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173026001687 metal binding site [ion binding]; metal-binding site 1173026001688 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1173026001689 catalytic site [active] 1173026001690 putative active site [active] 1173026001691 putative substrate binding site [chemical binding]; other site 1173026001692 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026001693 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1173026001694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026001695 putative ADP-binding pocket [chemical binding]; other site 1173026001696 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026001697 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1173026001698 putative NAD(P) binding site [chemical binding]; other site 1173026001699 active site 1173026001700 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1173026001701 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173026001702 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026001703 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173026001704 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173026001705 NAD binding site [chemical binding]; other site 1173026001706 homodimer interface [polypeptide binding]; other site 1173026001707 active site 1173026001708 substrate binding site [chemical binding]; other site 1173026001709 SET domain; Region: SET; pfam00856 1173026001710 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 1173026001711 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1173026001712 dimerization interface [polypeptide binding]; other site 1173026001713 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026001714 GAF domain; Region: GAF; pfam01590 1173026001715 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026001716 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026001717 metal binding site [ion binding]; metal-binding site 1173026001718 active site 1173026001719 I-site; other site 1173026001720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026001721 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1173026001722 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1173026001723 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173026001724 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1173026001725 RNA binding site [nucleotide binding]; other site 1173026001726 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1173026001727 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1173026001728 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1173026001729 G1 box; other site 1173026001730 GTP/Mg2+ binding site [chemical binding]; other site 1173026001731 Switch I region; other site 1173026001732 G2 box; other site 1173026001733 Switch II region; other site 1173026001734 G3 box; other site 1173026001735 G4 box; other site 1173026001736 G5 box; other site 1173026001737 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1173026001738 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026001739 putative active site [active] 1173026001740 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173026001741 NADPH bind site [chemical binding]; other site 1173026001742 putative FMN binding site [chemical binding]; other site 1173026001743 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173026001744 putative FMN binding site [chemical binding]; other site 1173026001745 NADPH bind site [chemical binding]; other site 1173026001746 pyruvate kinase; Provisional; Region: PRK06354 1173026001747 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1173026001748 domain interfaces; other site 1173026001749 active site 1173026001750 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1173026001751 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173026001752 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1173026001753 putative di-iron ligands [ion binding]; other site 1173026001754 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1173026001755 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1173026001756 transmembrane helices; other site 1173026001757 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1173026001758 homotrimer interaction site [polypeptide binding]; other site 1173026001759 active site 1173026001760 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173026001761 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1173026001762 tandem repeat interface [polypeptide binding]; other site 1173026001763 oligomer interface [polypeptide binding]; other site 1173026001764 active site residues [active] 1173026001765 EamA-like transporter family; Region: EamA; pfam00892 1173026001766 EamA-like transporter family; Region: EamA; pfam00892 1173026001767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026001768 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173026001769 putative ADP-binding pocket [chemical binding]; other site 1173026001770 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1173026001771 homodimer interface [polypeptide binding]; other site 1173026001772 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1173026001773 active site pocket [active] 1173026001774 hypothetical protein; Provisional; Region: PRK10621 1173026001775 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173026001776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026001777 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1173026001778 dimer interface [polypeptide binding]; other site 1173026001779 catalytic triad [active] 1173026001780 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1173026001781 substrate binding site [chemical binding]; other site 1173026001782 active site 1173026001783 four helix bundle protein; Region: TIGR02436 1173026001784 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1173026001785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026001786 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173026001787 NAD(P) binding site [chemical binding]; other site 1173026001788 active site 1173026001789 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173026001790 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173026001791 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173026001792 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026001793 putative active site [active] 1173026001794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026001795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026001796 AMIN domain; Region: AMIN; pfam11741 1173026001797 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026001798 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026001799 N-terminal plug; other site 1173026001800 ligand-binding site [chemical binding]; other site 1173026001801 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026001802 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026001803 siderophore binding site; other site 1173026001804 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 1173026001805 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1173026001806 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1173026001807 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1173026001808 active site 1173026001809 dimer interface [polypeptide binding]; other site 1173026001810 metal binding site [ion binding]; metal-binding site 1173026001811 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026001812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026001813 active site 1173026001814 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173026001815 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173026001816 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026001817 active site 1173026001818 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173026001819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026001820 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1173026001821 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173026001822 putative ADP-binding pocket [chemical binding]; other site 1173026001823 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173026001824 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173026001825 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173026001826 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1173026001827 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173026001828 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026001829 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026001830 protein binding site [polypeptide binding]; other site 1173026001831 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173026001832 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1173026001833 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1173026001834 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173026001835 active site 1173026001836 elongation factor P; Validated; Region: PRK00529 1173026001837 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1173026001838 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1173026001839 RNA binding site [nucleotide binding]; other site 1173026001840 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1173026001841 RNA binding site [nucleotide binding]; other site 1173026001842 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1173026001843 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173026001844 carboxyltransferase (CT) interaction site; other site 1173026001845 biotinylation site [posttranslational modification]; other site 1173026001846 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026001847 dimerization interface [polypeptide binding]; other site 1173026001848 putative DNA binding site [nucleotide binding]; other site 1173026001849 putative Zn2+ binding site [ion binding]; other site 1173026001850 Sporulation and spore germination; Region: Germane; pfam10646 1173026001851 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173026001852 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1173026001853 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1173026001854 dimer interface [polypeptide binding]; other site 1173026001855 motif 1; other site 1173026001856 active site 1173026001857 motif 2; other site 1173026001858 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1173026001859 putative deacylase active site [active] 1173026001860 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1173026001861 active site 1173026001862 motif 3; other site 1173026001863 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1173026001864 anticodon binding site; other site 1173026001865 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026001866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026001867 catalytic loop [active] 1173026001868 iron binding site [ion binding]; other site 1173026001869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026001870 binding surface 1173026001871 TPR motif; other site 1173026001872 TPR repeat; Region: TPR_11; pfam13414 1173026001873 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026001874 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026001875 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026001876 catalytic loop [active] 1173026001877 iron binding site [ion binding]; other site 1173026001878 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173026001879 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1173026001880 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1173026001881 V4R domain; Region: V4R; pfam02830 1173026001882 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1173026001883 homotrimer interaction site [polypeptide binding]; other site 1173026001884 putative active site [active] 1173026001885 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026001886 putative active site [active] 1173026001887 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1173026001888 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1173026001889 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173026001890 nucleotide binding site [chemical binding]; other site 1173026001891 NEF interaction site [polypeptide binding]; other site 1173026001892 SBD interface [polypeptide binding]; other site 1173026001893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026001894 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173026001895 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1173026001896 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173026001897 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173026001898 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026001899 TrkA-N domain; Region: TrkA_N; pfam02254 1173026001900 TrkA-C domain; Region: TrkA_C; pfam02080 1173026001901 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173026001902 active site 1173026001903 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1173026001904 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1173026001905 FMN binding site [chemical binding]; other site 1173026001906 active site 1173026001907 catalytic residues [active] 1173026001908 substrate binding site [chemical binding]; other site 1173026001909 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1173026001910 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173026001911 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1173026001912 substrate binding site [chemical binding]; other site 1173026001913 dimer interface [polypeptide binding]; other site 1173026001914 ATP binding site [chemical binding]; other site 1173026001915 D-xylulose kinase; Region: XylB; TIGR01312 1173026001916 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1173026001917 N- and C-terminal domain interface [polypeptide binding]; other site 1173026001918 active site 1173026001919 MgATP binding site [chemical binding]; other site 1173026001920 catalytic site [active] 1173026001921 metal binding site [ion binding]; metal-binding site 1173026001922 xylulose binding site [chemical binding]; other site 1173026001923 homodimer interface [polypeptide binding]; other site 1173026001924 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1173026001925 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1173026001926 putative ligand binding site [chemical binding]; other site 1173026001927 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1173026001928 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1173026001929 Walker A/P-loop; other site 1173026001930 ATP binding site [chemical binding]; other site 1173026001931 Q-loop/lid; other site 1173026001932 ABC transporter signature motif; other site 1173026001933 Walker B; other site 1173026001934 D-loop; other site 1173026001935 H-loop/switch region; other site 1173026001936 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1173026001937 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173026001938 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1173026001939 TM-ABC transporter signature motif; other site 1173026001940 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1173026001941 N- and C-terminal domain interface [polypeptide binding]; other site 1173026001942 D-xylulose kinase; Region: XylB; TIGR01312 1173026001943 active site 1173026001944 MgATP binding site [chemical binding]; other site 1173026001945 catalytic site [active] 1173026001946 metal binding site [ion binding]; metal-binding site 1173026001947 xylulose binding site [chemical binding]; other site 1173026001948 homodimer interface [polypeptide binding]; other site 1173026001949 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1173026001950 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1173026001951 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026001952 active site 1173026001953 NTP binding site [chemical binding]; other site 1173026001954 metal binding triad [ion binding]; metal-binding site 1173026001955 antibiotic binding site [chemical binding]; other site 1173026001956 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026001957 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026001958 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026001959 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026001960 siderophore binding site; other site 1173026001961 AMIN domain; Region: AMIN; pfam11741 1173026001962 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026001963 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026001964 N-terminal plug; other site 1173026001965 ligand-binding site [chemical binding]; other site 1173026001966 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026001967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026001968 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173026001969 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173026001970 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173026001971 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1173026001972 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1173026001973 homodimer interface [polypeptide binding]; other site 1173026001974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026001975 catalytic residue [active] 1173026001976 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1173026001977 GTP-binding protein YchF; Reviewed; Region: PRK09601 1173026001978 YchF GTPase; Region: YchF; cd01900 1173026001979 G1 box; other site 1173026001980 GTP/Mg2+ binding site [chemical binding]; other site 1173026001981 Switch I region; other site 1173026001982 G2 box; other site 1173026001983 Switch II region; other site 1173026001984 G3 box; other site 1173026001985 G4 box; other site 1173026001986 G5 box; other site 1173026001987 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1173026001988 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173026001989 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173026001990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026001991 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173026001992 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026001993 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173026001994 AAA ATPase domain; Region: AAA_16; pfam13191 1173026001995 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1173026001996 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1173026001997 active site 1173026001998 HIGH motif; other site 1173026001999 dimer interface [polypeptide binding]; other site 1173026002000 KMSKS motif; other site 1173026002001 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1173026002002 FAD binding site [chemical binding]; other site 1173026002003 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173026002004 EamA-like transporter family; Region: EamA; pfam00892 1173026002005 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 1173026002006 catalytic triad [active] 1173026002007 conserved cis-peptide bond; other site 1173026002008 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173026002009 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173026002010 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173026002011 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1173026002012 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1173026002013 DNA binding residues [nucleotide binding] 1173026002014 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026002015 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 1173026002016 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1173026002017 putative dimerization interface [polypeptide binding]; other site 1173026002018 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173026002019 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173026002020 Hexamer interface [polypeptide binding]; other site 1173026002021 Hexagonal pore residue; other site 1173026002022 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173026002023 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173026002024 Hexamer interface [polypeptide binding]; other site 1173026002025 Hexagonal pore residue; other site 1173026002026 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173026002027 putative trimer interface [polypeptide binding]; other site 1173026002028 putative CoA binding site [chemical binding]; other site 1173026002029 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173026002030 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1173026002031 trimer interface [polypeptide binding]; other site 1173026002032 active site 1173026002033 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173026002034 putative multimerization interface [polypeptide binding]; other site 1173026002035 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173026002036 putative multimerization interface [polypeptide binding]; other site 1173026002037 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173026002038 putative multimerization interface [polypeptide binding]; other site 1173026002039 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1173026002040 Hexamer/Pentamer interface [polypeptide binding]; other site 1173026002041 central pore; other site 1173026002042 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173026002043 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173026002044 Hexamer interface [polypeptide binding]; other site 1173026002045 Hexagonal pore residue; other site 1173026002046 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173026002047 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173026002048 Hexamer interface [polypeptide binding]; other site 1173026002049 Hexagonal pore residue; other site 1173026002050 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173026002051 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026002052 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 1173026002053 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026002054 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 1173026002055 guanine deaminase; Provisional; Region: PRK09228 1173026002056 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1173026002057 active site 1173026002058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026002059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173026002060 Predicted membrane protein [Function unknown]; Region: COG2860 1173026002061 UPF0126 domain; Region: UPF0126; pfam03458 1173026002062 UPF0126 domain; Region: UPF0126; pfam03458 1173026002063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1173026002064 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1173026002065 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173026002066 putative active site [active] 1173026002067 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173026002068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026002069 Coenzyme A binding pocket [chemical binding]; other site 1173026002070 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1173026002071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026002072 ATP binding site [chemical binding]; other site 1173026002073 putative Mg++ binding site [ion binding]; other site 1173026002074 nucleotide binding region [chemical binding]; other site 1173026002075 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1173026002076 ATP-binding site [chemical binding]; other site 1173026002077 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173026002078 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1173026002079 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026002080 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026002081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026002082 DNA binding residues [nucleotide binding] 1173026002083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026002084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026002085 Coenzyme A binding pocket [chemical binding]; other site 1173026002086 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173026002087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002088 S-adenosylmethionine binding site [chemical binding]; other site 1173026002089 hypothetical protein; Validated; Region: PRK01415 1173026002090 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1173026002091 active site residue [active] 1173026002092 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1173026002093 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173026002094 Ion channel; Region: Ion_trans_2; pfam07885 1173026002095 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026002096 TrkA-N domain; Region: TrkA_N; pfam02254 1173026002097 TrkA-C domain; Region: TrkA_C; pfam02080 1173026002098 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026002099 TrkA-N domain; Region: TrkA_N; pfam02254 1173026002100 TrkA-C domain; Region: TrkA_C; pfam02080 1173026002101 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 1173026002102 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173026002103 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173026002104 acetylornithine aminotransferase; Provisional; Region: PRK02627 1173026002105 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173026002106 inhibitor-cofactor binding pocket; inhibition site 1173026002107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026002108 catalytic residue [active] 1173026002109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026002110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026002111 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1173026002112 AMIN domain; Region: AMIN; pfam11741 1173026002113 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026002114 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026002115 N-terminal plug; other site 1173026002116 ligand-binding site [chemical binding]; other site 1173026002117 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026002118 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026002119 siderophore binding site; other site 1173026002120 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026002121 putative active site [active] 1173026002122 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173026002123 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1173026002124 active site 1173026002125 putative DNA-binding cleft [nucleotide binding]; other site 1173026002126 dimer interface [polypeptide binding]; other site 1173026002127 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1173026002128 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1173026002129 phosphate binding site [ion binding]; other site 1173026002130 putative substrate binding pocket [chemical binding]; other site 1173026002131 dimer interface [polypeptide binding]; other site 1173026002132 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 1173026002133 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1173026002134 dihydroorotase; Provisional; Region: PRK07575 1173026002135 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026002136 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1173026002137 active site 1173026002138 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173026002139 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173026002140 Catalytic site [active] 1173026002141 dihydroorotase; Provisional; Region: PRK07369 1173026002142 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026002143 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1173026002144 active site 1173026002145 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026002146 catalytic core [active] 1173026002147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026002148 catalytic core [active] 1173026002149 CAAX protease self-immunity; Region: Abi; pfam02517 1173026002150 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1173026002151 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026002152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026002153 active site 1173026002154 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1173026002155 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1173026002156 hinge; other site 1173026002157 active site 1173026002158 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1173026002159 putative active site [active] 1173026002160 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1173026002161 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1173026002162 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173026002163 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173026002164 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173026002165 putative dimer interface [polypeptide binding]; other site 1173026002166 N-terminal domain interface [polypeptide binding]; other site 1173026002167 putative substrate binding pocket (H-site) [chemical binding]; other site 1173026002168 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1173026002169 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 1173026002170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026002171 binding surface 1173026002172 TPR motif; other site 1173026002173 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1173026002174 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026002175 putative active site [active] 1173026002176 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1173026002177 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173026002178 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173026002179 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 1173026002180 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026002181 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026002182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026002183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002184 dimer interface [polypeptide binding]; other site 1173026002185 phosphorylation site [posttranslational modification] 1173026002186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002187 ATP binding site [chemical binding]; other site 1173026002188 Mg2+ binding site [ion binding]; other site 1173026002189 G-X-G motif; other site 1173026002190 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1173026002191 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1173026002192 putative active site cavity [active] 1173026002193 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 1173026002194 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026002195 active site 1173026002196 metal binding site [ion binding]; metal-binding site 1173026002197 DNA adenine methylase (dam); Region: dam; TIGR00571 1173026002198 Protein of unknown function (DUF751); Region: DUF751; pfam05421 1173026002199 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1173026002200 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1173026002201 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1173026002202 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173026002203 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1173026002204 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1173026002205 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173026002206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026002207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026002208 ligand binding site [chemical binding]; other site 1173026002209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002210 S-adenosylmethionine binding site [chemical binding]; other site 1173026002211 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 1173026002212 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1173026002213 GMP synthase; Reviewed; Region: guaA; PRK00074 1173026002214 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1173026002215 AMP/PPi binding site [chemical binding]; other site 1173026002216 candidate oxyanion hole; other site 1173026002217 catalytic triad [active] 1173026002218 potential glutamine specificity residues [chemical binding]; other site 1173026002219 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1173026002220 ATP Binding subdomain [chemical binding]; other site 1173026002221 Ligand Binding sites [chemical binding]; other site 1173026002222 Dimerization subdomain; other site 1173026002223 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1173026002224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026002225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026002226 putative substrate translocation pore; other site 1173026002227 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1173026002228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026002229 FeS/SAM binding site; other site 1173026002230 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1173026002231 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1173026002232 ribosomal protein S4(archaeal type)/S9(eukaryote cytosolic type); Region: rpsD_arch; TIGR01018 1173026002233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173026002234 RNA binding surface [nucleotide binding]; other site 1173026002235 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173026002236 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1173026002237 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1173026002238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002239 S-adenosylmethionine binding site [chemical binding]; other site 1173026002240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026002241 active site 1173026002242 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173026002243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026002244 DALR anticodon binding domain; Region: DALR_1; smart00836 1173026002245 anticodon binding site; other site 1173026002246 tRNA binding surface [nucleotide binding]; other site 1173026002247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026002248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026002249 putative switch regulator; other site 1173026002250 non-specific DNA interactions [nucleotide binding]; other site 1173026002251 DNA binding site [nucleotide binding] 1173026002252 sequence specific DNA binding site [nucleotide binding]; other site 1173026002253 putative cAMP binding site [chemical binding]; other site 1173026002254 PBP superfamily domain; Region: PBP_like_2; pfam12849 1173026002255 PBP superfamily domain; Region: PBP_like_2; pfam12849 1173026002256 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026002257 active site 1173026002258 ATP binding site [chemical binding]; other site 1173026002259 substrate binding site [chemical binding]; other site 1173026002260 activation loop (A-loop); other site 1173026002261 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 1173026002262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026002263 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1173026002264 putative dimerization interface [polypeptide binding]; other site 1173026002265 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173026002266 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026002267 catalytic residues [active] 1173026002268 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 1173026002269 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1173026002270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026002271 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1173026002272 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 1173026002273 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026002274 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026002275 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026002276 PAS fold; Region: PAS_4; pfam08448 1173026002277 PAS fold; Region: PAS_4; pfam08448 1173026002278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026002279 putative active site [active] 1173026002280 heme pocket [chemical binding]; other site 1173026002281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026002282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002283 dimer interface [polypeptide binding]; other site 1173026002284 phosphorylation site [posttranslational modification] 1173026002285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002286 ATP binding site [chemical binding]; other site 1173026002287 Mg2+ binding site [ion binding]; other site 1173026002288 G-X-G motif; other site 1173026002289 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026002290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002291 active site 1173026002292 phosphorylation site [posttranslational modification] 1173026002293 intermolecular recognition site; other site 1173026002294 dimerization interface [polypeptide binding]; other site 1173026002295 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173026002296 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1173026002297 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1173026002298 thiamine phosphate binding site [chemical binding]; other site 1173026002299 active site 1173026002300 pyrophosphate binding site [ion binding]; other site 1173026002301 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1173026002302 thiS-thiF/thiG interaction site; other site 1173026002303 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 1173026002304 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1173026002305 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173026002306 inhibitor-cofactor binding pocket; inhibition site 1173026002307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026002308 catalytic residue [active] 1173026002309 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 1173026002310 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1173026002311 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1173026002312 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1173026002313 metal binding site [ion binding]; metal-binding site 1173026002314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026002315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026002316 putative substrate translocation pore; other site 1173026002317 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 1173026002318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1173026002319 active site 1173026002320 motif I; other site 1173026002321 motif II; other site 1173026002322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1173026002323 motif II; other site 1173026002324 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1173026002325 RuvA N terminal domain; Region: RuvA_N; pfam01330 1173026002326 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1173026002327 PAS domain; Region: PAS_9; pfam13426 1173026002328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026002329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002330 dimer interface [polypeptide binding]; other site 1173026002331 phosphorylation site [posttranslational modification] 1173026002332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002333 ATP binding site [chemical binding]; other site 1173026002334 Mg2+ binding site [ion binding]; other site 1173026002335 G-X-G motif; other site 1173026002336 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026002337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002338 active site 1173026002339 phosphorylation site [posttranslational modification] 1173026002340 intermolecular recognition site; other site 1173026002341 dimerization interface [polypeptide binding]; other site 1173026002342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026002343 PAS fold; Region: PAS_3; pfam08447 1173026002344 putative active site [active] 1173026002345 heme pocket [chemical binding]; other site 1173026002346 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026002347 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026002348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026002349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002350 dimer interface [polypeptide binding]; other site 1173026002351 phosphorylation site [posttranslational modification] 1173026002352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002353 ATP binding site [chemical binding]; other site 1173026002354 Mg2+ binding site [ion binding]; other site 1173026002355 G-X-G motif; other site 1173026002356 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026002357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002358 active site 1173026002359 phosphorylation site [posttranslational modification] 1173026002360 intermolecular recognition site; other site 1173026002361 dimerization interface [polypeptide binding]; other site 1173026002362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002363 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026002364 active site 1173026002365 phosphorylation site [posttranslational modification] 1173026002366 intermolecular recognition site; other site 1173026002367 dimerization interface [polypeptide binding]; other site 1173026002368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026002369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002370 active site 1173026002371 phosphorylation site [posttranslational modification] 1173026002372 intermolecular recognition site; other site 1173026002373 dimerization interface [polypeptide binding]; other site 1173026002374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026002375 DNA binding residues [nucleotide binding] 1173026002376 dimerization interface [polypeptide binding]; other site 1173026002377 CHASE3 domain; Region: CHASE3; pfam05227 1173026002378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026002379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026002380 dimerization interface [polypeptide binding]; other site 1173026002381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002382 dimer interface [polypeptide binding]; other site 1173026002383 phosphorylation site [posttranslational modification] 1173026002384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002385 ATP binding site [chemical binding]; other site 1173026002386 Mg2+ binding site [ion binding]; other site 1173026002387 G-X-G motif; other site 1173026002388 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173026002389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002390 S-adenosylmethionine binding site [chemical binding]; other site 1173026002391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 1173026002392 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173026002393 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026002394 GAF domain; Region: GAF; pfam01590 1173026002395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002396 dimer interface [polypeptide binding]; other site 1173026002397 phosphorylation site [posttranslational modification] 1173026002398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002399 ATP binding site [chemical binding]; other site 1173026002400 Mg2+ binding site [ion binding]; other site 1173026002401 G-X-G motif; other site 1173026002402 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173026002403 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026002404 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026002405 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026002406 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026002407 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026002408 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026002409 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173026002410 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173026002411 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 1173026002412 metal-binding site [ion binding] 1173026002413 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173026002414 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173026002415 metal-binding site [ion binding] 1173026002416 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026002417 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026002418 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 1173026002419 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173026002420 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173026002421 DNA binding residues [nucleotide binding] 1173026002422 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1173026002423 dimer interface [polypeptide binding]; other site 1173026002424 metal binding site [ion binding]; metal-binding site 1173026002425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002426 S-adenosylmethionine binding site [chemical binding]; other site 1173026002427 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1173026002428 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1173026002429 active site 1173026002430 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1173026002431 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1173026002432 active site 1173026002433 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173026002434 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1173026002435 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1173026002436 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1173026002437 Moco binding site; other site 1173026002438 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1173026002439 metal coordination site [ion binding]; other site 1173026002440 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 1173026002441 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 1173026002442 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1173026002443 Homeodomain-like domain; Region: HTH_23; pfam13384 1173026002444 Winged helix-turn helix; Region: HTH_29; pfam13551 1173026002445 Winged helix-turn helix; Region: HTH_33; pfam13592 1173026002446 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173026002447 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1173026002448 P-loop, Walker A motif; other site 1173026002449 Base recognition motif; other site 1173026002450 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173026002451 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026002452 WD40 repeats; Region: WD40; smart00320 1173026002453 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026002454 structural tetrad; other site 1173026002455 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026002456 dimerization interface [polypeptide binding]; other site 1173026002457 putative DNA binding site [nucleotide binding]; other site 1173026002458 putative Zn2+ binding site [ion binding]; other site 1173026002459 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 1173026002460 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1173026002461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173026002462 nucleotide binding site [chemical binding]; other site 1173026002463 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1173026002464 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1173026002465 nucleotide binding site [chemical binding]; other site 1173026002466 CTP synthetase; Validated; Region: pyrG; PRK05380 1173026002467 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1173026002468 Catalytic site [active] 1173026002469 active site 1173026002470 UTP binding site [chemical binding]; other site 1173026002471 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1173026002472 active site 1173026002473 putative oxyanion hole; other site 1173026002474 catalytic triad [active] 1173026002475 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 1173026002476 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173026002477 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173026002478 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173026002479 active site 1173026002480 metal binding site [ion binding]; metal-binding site 1173026002481 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026002482 putative active site [active] 1173026002483 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1173026002484 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173026002485 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026002486 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026002487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026002488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026002489 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 1173026002490 GIY-YIG motif/motif A; other site 1173026002491 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026002492 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026002493 active site 1173026002494 ATP binding site [chemical binding]; other site 1173026002495 substrate binding site [chemical binding]; other site 1173026002496 activation loop (A-loop); other site 1173026002497 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1173026002498 peripheral dimer interface [polypeptide binding]; other site 1173026002499 core dimer interface [polypeptide binding]; other site 1173026002500 L10 interface [polypeptide binding]; other site 1173026002501 L11 interface [polypeptide binding]; other site 1173026002502 putative EF-Tu interaction site [polypeptide binding]; other site 1173026002503 putative EF-G interaction site [polypeptide binding]; other site 1173026002504 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1173026002505 23S rRNA interface [nucleotide binding]; other site 1173026002506 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1173026002507 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1173026002508 mRNA/rRNA interface [nucleotide binding]; other site 1173026002509 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1173026002510 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1173026002511 23S rRNA interface [nucleotide binding]; other site 1173026002512 L7/L12 interface [polypeptide binding]; other site 1173026002513 putative thiostrepton binding site; other site 1173026002514 L25 interface [polypeptide binding]; other site 1173026002515 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1173026002516 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1173026002517 putative homodimer interface [polypeptide binding]; other site 1173026002518 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1173026002519 heterodimer interface [polypeptide binding]; other site 1173026002520 homodimer interface [polypeptide binding]; other site 1173026002521 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1173026002522 ribosomal protein L19; Region: rpl19; CHL00084 1173026002523 Mediator complex subunit 24 N-terminal; Region: Med24_N; pfam11277 1173026002524 CpeS-like protein; Region: CpeS; pfam09367 1173026002525 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173026002526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1173026002527 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173026002528 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173026002529 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1173026002530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173026002531 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173026002532 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173026002533 pantothenate kinase; Reviewed; Region: PRK13331 1173026002534 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173026002535 nudix motif; other site 1173026002536 argininosuccinate lyase; Provisional; Region: PRK00855 1173026002537 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1173026002538 active sites [active] 1173026002539 tetramer interface [polypeptide binding]; other site 1173026002540 GAF domain; Region: GAF_3; pfam13492 1173026002541 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173026002542 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173026002543 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1173026002544 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1173026002545 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173026002546 P loop; other site 1173026002547 GTP binding site [chemical binding]; other site 1173026002548 transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634 1173026002549 putative RNA binding site [nucleotide binding]; other site 1173026002550 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1173026002551 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1173026002552 AMIN domain; Region: AMIN; pfam11741 1173026002553 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1173026002554 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1173026002555 active site 1173026002556 metal binding site [ion binding]; metal-binding site 1173026002557 glutamate racemase; Provisional; Region: PRK00865 1173026002558 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173026002559 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173026002560 substrate binding pocket [chemical binding]; other site 1173026002561 chain length determination region; other site 1173026002562 substrate-Mg2+ binding site; other site 1173026002563 catalytic residues [active] 1173026002564 aspartate-rich region 1; other site 1173026002565 active site lid residues [active] 1173026002566 aspartate-rich region 2; other site 1173026002567 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173026002568 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173026002569 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1173026002570 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026002571 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1173026002572 Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142 1173026002573 Protein of unknown function (DUF_B2219); Region: PPO1_KFDV; pfam12143 1173026002574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002575 S-adenosylmethionine binding site [chemical binding]; other site 1173026002576 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173026002577 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1173026002578 active site residue [active] 1173026002579 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1173026002580 active site residue [active] 1173026002581 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1173026002582 FecR protein; Region: FecR; pfam04773 1173026002583 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173026002584 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 1173026002585 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026002586 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026002587 active site 1173026002588 ATP binding site [chemical binding]; other site 1173026002589 substrate binding site [chemical binding]; other site 1173026002590 activation loop (A-loop); other site 1173026002591 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173026002592 LabA_like proteins; Region: LabA; cd10911 1173026002593 putative metal binding site [ion binding]; other site 1173026002594 2-isopropylmalate synthase; Validated; Region: PRK00915 1173026002595 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1173026002596 active site 1173026002597 catalytic residues [active] 1173026002598 metal binding site [ion binding]; metal-binding site 1173026002599 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1173026002600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026002601 S-adenosylmethionine binding site [chemical binding]; other site 1173026002602 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173026002603 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173026002604 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1173026002605 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1173026002606 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173026002607 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173026002608 dimer interface [polypeptide binding]; other site 1173026002609 ssDNA binding site [nucleotide binding]; other site 1173026002610 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173026002611 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1173026002612 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 1173026002613 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1173026002614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026002615 Walker A motif; other site 1173026002616 ATP binding site [chemical binding]; other site 1173026002617 Walker B motif; other site 1173026002618 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 1173026002619 RxxxH motif; other site 1173026002620 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1173026002621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1173026002622 motif II; other site 1173026002623 NurA nuclease; Region: NurA; smart00933 1173026002624 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 1173026002625 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1173026002626 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1173026002627 generic binding surface II; other site 1173026002628 generic binding surface I; other site 1173026002629 recombinase A; Provisional; Region: recA; PRK09354 1173026002630 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1173026002631 hexamer interface [polypeptide binding]; other site 1173026002632 Walker A motif; other site 1173026002633 ATP binding site [chemical binding]; other site 1173026002634 Walker B motif; other site 1173026002635 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 1173026002636 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 1173026002637 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1173026002638 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1173026002639 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173026002640 Cytochrome P450; Region: p450; pfam00067 1173026002641 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1173026002642 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1173026002643 dimer interface [polypeptide binding]; other site 1173026002644 putative anticodon binding site; other site 1173026002645 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1173026002646 motif 1; other site 1173026002647 active site 1173026002648 motif 2; other site 1173026002649 motif 3; other site 1173026002650 KTSC domain; Region: KTSC; pfam13619 1173026002651 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026002652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026002653 Coenzyme A binding pocket [chemical binding]; other site 1173026002654 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1173026002655 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1173026002656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002657 dimer interface [polypeptide binding]; other site 1173026002658 phosphorylation site [posttranslational modification] 1173026002659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002660 ATP binding site [chemical binding]; other site 1173026002661 Mg2+ binding site [ion binding]; other site 1173026002662 G-X-G motif; other site 1173026002663 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173026002664 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026002665 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026002666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026002667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026002668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026002669 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173026002670 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173026002671 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173026002672 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1173026002673 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1173026002674 TPP-binding site; other site 1173026002675 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173026002676 PYR/PP interface [polypeptide binding]; other site 1173026002677 dimer interface [polypeptide binding]; other site 1173026002678 TPP binding site [chemical binding]; other site 1173026002679 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173026002680 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1173026002681 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1173026002682 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026002683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026002684 Coenzyme A binding pocket [chemical binding]; other site 1173026002685 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1173026002686 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173026002687 Walker A/P-loop; other site 1173026002688 ATP binding site [chemical binding]; other site 1173026002689 Q-loop/lid; other site 1173026002690 ABC transporter signature motif; other site 1173026002691 Walker B; other site 1173026002692 D-loop; other site 1173026002693 H-loop/switch region; other site 1173026002694 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026002695 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026002696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026002697 Walker A/P-loop; other site 1173026002698 ATP binding site [chemical binding]; other site 1173026002699 Q-loop/lid; other site 1173026002700 ABC transporter signature motif; other site 1173026002701 Walker B; other site 1173026002702 D-loop; other site 1173026002703 H-loop/switch region; other site 1173026002704 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026002705 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026002706 active site 1173026002707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026002708 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026002709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026002710 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 1173026002711 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1173026002712 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1173026002713 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173026002714 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173026002715 homodimer interface [polypeptide binding]; other site 1173026002716 Walker A motif; other site 1173026002717 ATP binding site [chemical binding]; other site 1173026002718 hydroxycobalamin binding site [chemical binding]; other site 1173026002719 Walker B motif; other site 1173026002720 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1173026002721 putative ADP-ribose binding site [chemical binding]; other site 1173026002722 putative active site [active] 1173026002723 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 1173026002724 deoxyhypusine synthase; Region: dhys; TIGR00321 1173026002725 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1173026002726 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1173026002727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026002728 motif II; other site 1173026002729 Cache domain; Region: Cache_1; pfam02743 1173026002730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026002731 dimerization interface [polypeptide binding]; other site 1173026002732 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026002733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026002734 putative active site [active] 1173026002735 heme pocket [chemical binding]; other site 1173026002736 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1173026002737 glutaminase A; Region: Gln_ase; TIGR03814 1173026002738 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1173026002739 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026002740 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1173026002741 Amidinotransferase; Region: Amidinotransf; cl12043 1173026002742 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1173026002743 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 1173026002744 homodimer interface [polypeptide binding]; other site 1173026002745 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026002746 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026002747 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026002748 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026002749 aspartate kinase; Provisional; Region: PRK07431 1173026002750 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1173026002751 putative catalytic residues [active] 1173026002752 putative nucleotide binding site [chemical binding]; other site 1173026002753 putative aspartate binding site [chemical binding]; other site 1173026002754 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173026002755 putative allosteric regulatory site; other site 1173026002756 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173026002757 putative allosteric regulatory residue; other site 1173026002758 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1173026002759 putative allosteric regulatory site; other site 1173026002760 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1173026002761 putative allosteric regulatory residue; other site 1173026002762 Membrane protein of unknown function; Region: DUF360; cl00850 1173026002763 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173026002764 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173026002765 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173026002766 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1173026002767 ABC transporter G-25; Provisional; Region: PLN03211 1173026002768 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1173026002769 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1173026002770 interface (dimer of trimers) [polypeptide binding]; other site 1173026002771 Substrate-binding/catalytic site; other site 1173026002772 Zn-binding sites [ion binding]; other site 1173026002773 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 1173026002774 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 1173026002775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026002776 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026002777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026002778 DNA binding residues [nucleotide binding] 1173026002779 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1173026002780 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173026002781 dimer interface [polypeptide binding]; other site 1173026002782 motif 1; other site 1173026002783 active site 1173026002784 motif 2; other site 1173026002785 motif 3; other site 1173026002786 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1173026002787 anticodon binding site; other site 1173026002788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026002789 Coenzyme A binding pocket [chemical binding]; other site 1173026002790 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026002791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002792 active site 1173026002793 phosphorylation site [posttranslational modification] 1173026002794 intermolecular recognition site; other site 1173026002795 dimerization interface [polypeptide binding]; other site 1173026002796 DNA gyrase subunit A; Validated; Region: PRK05560 1173026002797 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173026002798 CAP-like domain; other site 1173026002799 active site 1173026002800 primary dimer interface [polypeptide binding]; other site 1173026002801 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026002802 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1173026002803 hypothetical protein; Validated; Region: PRK00029 1173026002804 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026002805 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026002806 trimer interface [polypeptide binding]; other site 1173026002807 active site 1173026002808 CoA binding site [chemical binding]; other site 1173026002809 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026002810 trimer interface [polypeptide binding]; other site 1173026002811 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026002812 active site 1173026002813 CoA binding site [chemical binding]; other site 1173026002814 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1173026002815 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026002816 putative ADP-binding pocket [chemical binding]; other site 1173026002817 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026002818 active site 1173026002819 ATP binding site [chemical binding]; other site 1173026002820 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173026002821 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173026002822 substrate binding site [chemical binding]; other site 1173026002823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026002824 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026002825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026002826 Walker A/P-loop; other site 1173026002827 ATP binding site [chemical binding]; other site 1173026002828 Q-loop/lid; other site 1173026002829 ABC transporter signature motif; other site 1173026002830 Walker B; other site 1173026002831 D-loop; other site 1173026002832 H-loop/switch region; other site 1173026002833 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1173026002834 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026002835 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026002836 active site 1173026002837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026002838 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026002839 dimerization interface [polypeptide binding]; other site 1173026002840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026002841 dimer interface [polypeptide binding]; other site 1173026002842 phosphorylation site [posttranslational modification] 1173026002843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026002844 ATP binding site [chemical binding]; other site 1173026002845 Mg2+ binding site [ion binding]; other site 1173026002846 G-X-G motif; other site 1173026002847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026002848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002849 active site 1173026002850 phosphorylation site [posttranslational modification] 1173026002851 intermolecular recognition site; other site 1173026002852 dimerization interface [polypeptide binding]; other site 1173026002853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026002854 DNA binding site [nucleotide binding] 1173026002855 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173026002856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026002857 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026002858 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1173026002859 four helix bundle protein; Region: TIGR02436 1173026002860 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026002861 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1173026002862 FtsX-like permease family; Region: FtsX; pfam02687 1173026002863 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026002864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026002865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026002866 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173026002867 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173026002868 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1173026002869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026002870 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1173026002871 putative ADP-binding pocket [chemical binding]; other site 1173026002872 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 1173026002873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026002874 FeS/SAM binding site; other site 1173026002875 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1173026002876 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1173026002877 GIY-YIG motif/motif A; other site 1173026002878 active site 1173026002879 catalytic site [active] 1173026002880 putative DNA binding site [nucleotide binding]; other site 1173026002881 metal binding site [ion binding]; metal-binding site 1173026002882 UvrB/uvrC motif; Region: UVR; pfam02151 1173026002883 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1173026002884 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026002885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026002886 active site 1173026002887 phosphorylation site [posttranslational modification] 1173026002888 intermolecular recognition site; other site 1173026002889 dimerization interface [polypeptide binding]; other site 1173026002890 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1173026002891 intersubunit interface [polypeptide binding]; other site 1173026002892 active site 1173026002893 catalytic residue [active] 1173026002894 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1173026002895 Recombination protein O N terminal; Region: RecO_N; pfam11967 1173026002896 Recombination protein O C terminal; Region: RecO_C; pfam02565 1173026002897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026002898 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173026002899 putative substrate translocation pore; other site 1173026002900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026002901 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026002902 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1173026002903 active site 1173026002904 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1173026002905 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1173026002906 phosphoglyceromutase; Provisional; Region: PRK05434 1173026002907 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173026002908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026002909 Walker A/P-loop; other site 1173026002910 ATP binding site [chemical binding]; other site 1173026002911 Q-loop/lid; other site 1173026002912 ABC transporter signature motif; other site 1173026002913 Walker B; other site 1173026002914 D-loop; other site 1173026002915 H-loop/switch region; other site 1173026002916 ABC transporter; Region: ABC_tran_2; pfam12848 1173026002917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173026002918 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1173026002919 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1173026002920 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1173026002921 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1173026002922 RF-1 domain; Region: RF-1; pfam00472 1173026002923 ribosomal protein L31; Validated; Region: rpl31; CHL00136 1173026002924 ribosomal protein S9; Region: rps9; CHL00079 1173026002925 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1173026002926 23S rRNA interface [nucleotide binding]; other site 1173026002927 L3 interface [polypeptide binding]; other site 1173026002928 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1173026002929 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1173026002930 dimerization interface 3.5A [polypeptide binding]; other site 1173026002931 active site 1173026002932 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1173026002933 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1173026002934 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1173026002935 alphaNTD - beta interaction site [polypeptide binding]; other site 1173026002936 alphaNTD homodimer interface [polypeptide binding]; other site 1173026002937 alphaNTD - beta' interaction site [polypeptide binding]; other site 1173026002938 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1173026002939 30S ribosomal protein S11; Validated; Region: PRK05309 1173026002940 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1173026002941 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1173026002942 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1173026002943 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1173026002944 rRNA binding site [nucleotide binding]; other site 1173026002945 predicted 30S ribosome binding site; other site 1173026002946 adenylate kinase; Provisional; Region: adk; PRK02496 1173026002947 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1173026002948 AMP-binding site [chemical binding]; other site 1173026002949 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1173026002950 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1173026002951 SecY translocase; Region: SecY; pfam00344 1173026002952 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1173026002953 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1173026002954 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1173026002955 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1173026002956 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1173026002957 23S rRNA interface [nucleotide binding]; other site 1173026002958 L21e interface [polypeptide binding]; other site 1173026002959 5S rRNA interface [nucleotide binding]; other site 1173026002960 L27 interface [polypeptide binding]; other site 1173026002961 L5 interface [polypeptide binding]; other site 1173026002962 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1173026002963 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173026002964 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1173026002965 ribosomal protein S8; Region: rps8; CHL00042 1173026002966 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1173026002967 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1173026002968 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1173026002969 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1173026002970 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1173026002971 RNA binding site [nucleotide binding]; other site 1173026002972 ribosomal protein L14; Region: rpl14; CHL00057 1173026002973 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1173026002974 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1173026002975 23S rRNA interface [nucleotide binding]; other site 1173026002976 putative translocon interaction site; other site 1173026002977 signal recognition particle (SRP54) interaction site; other site 1173026002978 L23 interface [polypeptide binding]; other site 1173026002979 trigger factor interaction site; other site 1173026002980 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1173026002981 23S rRNA interface [nucleotide binding]; other site 1173026002982 5S rRNA interface [nucleotide binding]; other site 1173026002983 putative antibiotic binding site [chemical binding]; other site 1173026002984 L25 interface [polypeptide binding]; other site 1173026002985 L27 interface [polypeptide binding]; other site 1173026002986 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1173026002987 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1173026002988 G-X-X-G motif; other site 1173026002989 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1173026002990 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1173026002991 putative translocon binding site; other site 1173026002992 protein-rRNA interface [nucleotide binding]; other site 1173026002993 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1173026002994 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1173026002995 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1173026002996 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1173026002997 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1173026002998 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1173026002999 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1173026003000 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 1173026003001 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173026003002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026003003 Walker A motif; other site 1173026003004 ATP binding site [chemical binding]; other site 1173026003005 Walker B motif; other site 1173026003006 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1173026003007 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1173026003008 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173026003009 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173026003010 dimer interface [polypeptide binding]; other site 1173026003011 [2Fe-2S] cluster binding site [ion binding]; other site 1173026003012 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173026003013 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173026003014 dimer interface [polypeptide binding]; other site 1173026003015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026003016 catalytic residue [active] 1173026003017 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173026003018 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1173026003019 dimer interface [polypeptide binding]; other site 1173026003020 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173026003021 catalytic triad [active] 1173026003022 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 1173026003023 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1173026003024 active site 1173026003025 substrate binding site [chemical binding]; other site 1173026003026 metal binding site [ion binding]; metal-binding site 1173026003027 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 1173026003028 CP12 domain; Region: CP12; pfam02672 1173026003029 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 1173026003030 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1173026003031 Zn binding site [ion binding]; other site 1173026003032 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1173026003033 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1173026003034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026003035 catalytic residue [active] 1173026003036 glycogen synthase; Provisional; Region: glgA; PRK00654 1173026003037 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1173026003038 ADP-binding pocket [chemical binding]; other site 1173026003039 homodimer interface [polypeptide binding]; other site 1173026003040 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1173026003041 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1173026003042 domain interfaces; other site 1173026003043 active site 1173026003044 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026003045 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003046 TPR repeat; Region: TPR_11; pfam13414 1173026003047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026003048 TPR motif; other site 1173026003049 binding surface 1173026003050 Putative transcription activator [Transcription]; Region: TenA; COG0819 1173026003051 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 1173026003052 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026003053 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173026003054 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1173026003055 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1173026003056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173026003057 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173026003058 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173026003059 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 1173026003060 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026003061 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026003062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026003063 Walker A/P-loop; other site 1173026003064 ATP binding site [chemical binding]; other site 1173026003065 Q-loop/lid; other site 1173026003066 ABC transporter signature motif; other site 1173026003067 Walker B; other site 1173026003068 D-loop; other site 1173026003069 H-loop/switch region; other site 1173026003070 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 1173026003071 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 1173026003072 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1173026003073 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026003074 catalytic residues [active] 1173026003075 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173026003076 active site residue [active] 1173026003077 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1173026003078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003079 ATP binding site [chemical binding]; other site 1173026003080 Mg2+ binding site [ion binding]; other site 1173026003081 G-X-G motif; other site 1173026003082 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1173026003083 ATP binding site [chemical binding]; other site 1173026003084 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1173026003085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026003086 Coenzyme A binding pocket [chemical binding]; other site 1173026003087 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1173026003088 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173026003089 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026003090 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173026003091 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1173026003092 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173026003093 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1173026003094 active site 1173026003095 Zn binding site [ion binding]; other site 1173026003096 DNA gyrase subunit A; Validated; Region: PRK05560 1173026003097 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1173026003098 CAP-like domain; other site 1173026003099 active site 1173026003100 primary dimer interface [polypeptide binding]; other site 1173026003101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026003102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026003103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026003104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026003105 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026003106 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1173026003107 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1173026003108 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1173026003109 putative active site [active] 1173026003110 catalytic triad [active] 1173026003111 putative dimer interface [polypeptide binding]; other site 1173026003112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026003113 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1173026003114 ATP-grasp domain; Region: ATP-grasp; pfam02222 1173026003115 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026003116 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003117 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1173026003118 active site 1173026003119 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 1173026003120 active site 1173026003121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026003122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026003123 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1173026003124 oligomerization interface [polypeptide binding]; other site 1173026003125 active site 1173026003126 metal binding site [ion binding]; metal-binding site 1173026003127 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 1173026003128 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1173026003129 homodimer interface [polypeptide binding]; other site 1173026003130 active site 1173026003131 heterodimer interface [polypeptide binding]; other site 1173026003132 catalytic residue [active] 1173026003133 metal binding site [ion binding]; metal-binding site 1173026003134 RbcX protein; Region: RcbX; pfam02341 1173026003135 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1173026003136 multimerization interface [polypeptide binding]; other site 1173026003137 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 1173026003138 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 1173026003139 putative multimerization interface [polypeptide binding]; other site 1173026003140 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1173026003141 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1173026003142 YCII-related domain; Region: YCII; cl00999 1173026003143 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173026003144 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1173026003145 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 1173026003146 ResB-like family; Region: ResB; pfam05140 1173026003147 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1173026003148 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1173026003149 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1173026003150 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173026003151 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026003152 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026003153 phycobillisome linker protein; Region: apcE; CHL00091 1173026003154 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026003155 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026003156 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026003157 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026003158 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026003159 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026003160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026003161 S-adenosylmethionine binding site [chemical binding]; other site 1173026003162 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1173026003163 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1173026003164 ATP synthase CF0 A subunit; Region: atpI; CHL00046 1173026003165 ATP synthase CF0 C subunit; Region: atpH; CHL00061 1173026003166 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1173026003167 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1173026003168 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 1173026003169 ATP synthase CF0 B subunit; Region: atpF; CHL00019 1173026003170 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1173026003171 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1173026003172 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1173026003173 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173026003174 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1173026003175 beta subunit interaction interface [polypeptide binding]; other site 1173026003176 Walker A motif; other site 1173026003177 ATP binding site [chemical binding]; other site 1173026003178 Walker B motif; other site 1173026003179 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173026003180 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1173026003181 core domain interface [polypeptide binding]; other site 1173026003182 delta subunit interface [polypeptide binding]; other site 1173026003183 epsilon subunit interface [polypeptide binding]; other site 1173026003184 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1173026003185 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1173026003186 active site residue [active] 1173026003187 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1173026003188 active site residue [active] 1173026003189 OsmC-like protein; Region: OsmC; pfam02566 1173026003190 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173026003191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1173026003192 active site 1173026003193 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173026003194 NMT1-like family; Region: NMT1_2; pfam13379 1173026003195 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026003196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026003197 ABC-ATPase subunit interface; other site 1173026003198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173026003199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026003200 Walker A/P-loop; other site 1173026003201 ATP binding site [chemical binding]; other site 1173026003202 Q-loop/lid; other site 1173026003203 ABC transporter signature motif; other site 1173026003204 Walker B; other site 1173026003205 D-loop; other site 1173026003206 H-loop/switch region; other site 1173026003207 cyanate hydratase; Validated; Region: PRK02866 1173026003208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1173026003209 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1173026003210 oligomer interface [polypeptide binding]; other site 1173026003211 active site 1173026003212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026003213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026003214 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1173026003215 gamma-glutamyl kinase; Provisional; Region: PRK05429 1173026003216 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1173026003217 nucleotide binding site [chemical binding]; other site 1173026003218 homotetrameric interface [polypeptide binding]; other site 1173026003219 putative phosphate binding site [ion binding]; other site 1173026003220 putative allosteric binding site; other site 1173026003221 PUA domain; Region: PUA; pfam01472 1173026003222 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1173026003223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026003224 YceG-like family; Region: YceG; pfam02618 1173026003225 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1173026003226 dimerization interface [polypeptide binding]; other site 1173026003227 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1173026003228 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 1173026003229 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1173026003230 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026003231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026003232 Coenzyme A binding pocket [chemical binding]; other site 1173026003233 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026003234 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026003235 active site 1173026003236 metal binding site [ion binding]; metal-binding site 1173026003237 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1173026003238 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1173026003239 MutS domain I; Region: MutS_I; pfam01624 1173026003240 MutS domain II; Region: MutS_II; pfam05188 1173026003241 MutS domain III; Region: MutS_III; pfam05192 1173026003242 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1173026003243 Walker A/P-loop; other site 1173026003244 ATP binding site [chemical binding]; other site 1173026003245 Q-loop/lid; other site 1173026003246 ABC transporter signature motif; other site 1173026003247 Walker B; other site 1173026003248 D-loop; other site 1173026003249 H-loop/switch region; other site 1173026003250 EamA-like transporter family; Region: EamA; pfam00892 1173026003251 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173026003252 EamA-like transporter family; Region: EamA; pfam00892 1173026003253 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1173026003254 nudix motif; other site 1173026003255 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 1173026003256 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1173026003257 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1173026003258 homodimer interface [polypeptide binding]; other site 1173026003259 NADP binding site [chemical binding]; other site 1173026003260 substrate binding site [chemical binding]; other site 1173026003261 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1173026003262 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1173026003263 substrate binding pocket [chemical binding]; other site 1173026003264 chain length determination region; other site 1173026003265 substrate-Mg2+ binding site; other site 1173026003266 catalytic residues [active] 1173026003267 aspartate-rich region 1; other site 1173026003268 active site lid residues [active] 1173026003269 aspartate-rich region 2; other site 1173026003270 Divergent PAP2 family; Region: DUF212; pfam02681 1173026003271 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 1173026003272 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1173026003273 active site 1173026003274 hydrophilic channel; other site 1173026003275 dimerization interface [polypeptide binding]; other site 1173026003276 catalytic residues [active] 1173026003277 active site lid [active] 1173026003278 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 1173026003279 Caspase domain; Region: Peptidase_C14; pfam00656 1173026003280 PQQ-like domain; Region: PQQ_2; pfam13360 1173026003281 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026003282 structural tetrad; other site 1173026003283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1173026003284 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173026003285 Phytase; Region: Phytase; cl17685 1173026003286 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173026003287 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173026003288 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173026003289 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1173026003290 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173026003291 ABC1 family; Region: ABC1; cl17513 1173026003292 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1173026003293 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1173026003294 Substrate binding site; other site 1173026003295 Cupin domain; Region: Cupin_2; cl17218 1173026003296 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026003297 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173026003298 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026003299 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026003300 FtsX-like permease family; Region: FtsX; pfam02687 1173026003301 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173026003302 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173026003303 [2Fe-2S] cluster binding site [ion binding]; other site 1173026003304 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173026003305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173026003306 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026003307 Walker A/P-loop; other site 1173026003308 ATP binding site [chemical binding]; other site 1173026003309 Q-loop/lid; other site 1173026003310 ABC transporter signature motif; other site 1173026003311 Walker B; other site 1173026003312 D-loop; other site 1173026003313 H-loop/switch region; other site 1173026003314 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173026003315 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173026003316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026003317 motif II; other site 1173026003318 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1173026003319 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1173026003320 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173026003321 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1173026003322 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1173026003323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026003324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003325 active site 1173026003326 phosphorylation site [posttranslational modification] 1173026003327 intermolecular recognition site; other site 1173026003328 dimerization interface [polypeptide binding]; other site 1173026003329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026003330 DNA binding residues [nucleotide binding] 1173026003331 dimerization interface [polypeptide binding]; other site 1173026003332 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026003333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003334 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026003335 putative active site [active] 1173026003336 heme pocket [chemical binding]; other site 1173026003337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003338 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026003339 putative active site [active] 1173026003340 heme pocket [chemical binding]; other site 1173026003341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003342 putative active site [active] 1173026003343 heme pocket [chemical binding]; other site 1173026003344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026003345 dimer interface [polypeptide binding]; other site 1173026003346 phosphorylation site [posttranslational modification] 1173026003347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003348 ATP binding site [chemical binding]; other site 1173026003349 Mg2+ binding site [ion binding]; other site 1173026003350 G-X-G motif; other site 1173026003351 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173026003352 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026003353 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026003354 PAS domain S-box; Region: sensory_box; TIGR00229 1173026003355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003356 putative active site [active] 1173026003357 heme pocket [chemical binding]; other site 1173026003358 PAS domain S-box; Region: sensory_box; TIGR00229 1173026003359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003360 putative active site [active] 1173026003361 heme pocket [chemical binding]; other site 1173026003362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026003363 dimer interface [polypeptide binding]; other site 1173026003364 phosphorylation site [posttranslational modification] 1173026003365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003366 ATP binding site [chemical binding]; other site 1173026003367 Mg2+ binding site [ion binding]; other site 1173026003368 G-X-G motif; other site 1173026003369 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026003370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003371 active site 1173026003372 phosphorylation site [posttranslational modification] 1173026003373 intermolecular recognition site; other site 1173026003374 dimerization interface [polypeptide binding]; other site 1173026003375 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026003376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003377 active site 1173026003378 phosphorylation site [posttranslational modification] 1173026003379 intermolecular recognition site; other site 1173026003380 dimerization interface [polypeptide binding]; other site 1173026003381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003382 PAS fold; Region: PAS_3; pfam08447 1173026003383 putative active site [active] 1173026003384 heme pocket [chemical binding]; other site 1173026003385 PAS domain S-box; Region: sensory_box; TIGR00229 1173026003386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003387 putative active site [active] 1173026003388 heme pocket [chemical binding]; other site 1173026003389 PAS fold; Region: PAS_4; pfam08448 1173026003390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026003391 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026003392 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026003393 GAF domain; Region: GAF; pfam01590 1173026003394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026003395 dimer interface [polypeptide binding]; other site 1173026003396 phosphorylation site [posttranslational modification] 1173026003397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003398 ATP binding site [chemical binding]; other site 1173026003399 Mg2+ binding site [ion binding]; other site 1173026003400 G-X-G motif; other site 1173026003401 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1173026003402 CheB methylesterase; Region: CheB_methylest; pfam01339 1173026003403 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1173026003404 CheB methylesterase; Region: CheB_methylest; pfam01339 1173026003405 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173026003406 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173026003407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026003408 S-adenosylmethionine binding site [chemical binding]; other site 1173026003409 PAS fold; Region: PAS; pfam00989 1173026003410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1173026003411 putative active site [active] 1173026003412 heme pocket [chemical binding]; other site 1173026003413 PAS fold; Region: PAS; pfam00989 1173026003414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003415 putative active site [active] 1173026003416 heme pocket [chemical binding]; other site 1173026003417 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026003418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003419 putative active site [active] 1173026003420 heme pocket [chemical binding]; other site 1173026003421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026003422 dimer interface [polypeptide binding]; other site 1173026003423 phosphorylation site [posttranslational modification] 1173026003424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003425 ATP binding site [chemical binding]; other site 1173026003426 Mg2+ binding site [ion binding]; other site 1173026003427 G-X-G motif; other site 1173026003428 MraW methylase family; Region: Methyltransf_5; cl17771 1173026003429 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1173026003430 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173026003431 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173026003432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003433 ATP binding site [chemical binding]; other site 1173026003434 Mg2+ binding site [ion binding]; other site 1173026003435 G-X-G motif; other site 1173026003436 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1173026003437 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026003438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003439 active site 1173026003440 phosphorylation site [posttranslational modification] 1173026003441 intermolecular recognition site; other site 1173026003442 dimerization interface [polypeptide binding]; other site 1173026003443 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026003444 putative binding surface; other site 1173026003445 active site 1173026003446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026003447 binding surface 1173026003448 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026003449 TPR motif; other site 1173026003450 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1173026003451 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173026003452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173026003453 dimer interface [polypeptide binding]; other site 1173026003454 putative CheW interface [polypeptide binding]; other site 1173026003455 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173026003456 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026003457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003458 active site 1173026003459 phosphorylation site [posttranslational modification] 1173026003460 intermolecular recognition site; other site 1173026003461 dimerization interface [polypeptide binding]; other site 1173026003462 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173026003463 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1173026003464 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1173026003465 Ligand Binding Site [chemical binding]; other site 1173026003466 cytochrome c biogenesis protein; Region: ccsA; CHL00045 1173026003467 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173026003468 PBP superfamily domain; Region: PBP_like_2; cl17296 1173026003469 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173026003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026003471 dimer interface [polypeptide binding]; other site 1173026003472 conserved gate region; other site 1173026003473 putative PBP binding loops; other site 1173026003474 ABC-ATPase subunit interface; other site 1173026003475 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1173026003476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026003477 dimer interface [polypeptide binding]; other site 1173026003478 conserved gate region; other site 1173026003479 putative PBP binding loops; other site 1173026003480 ABC-ATPase subunit interface; other site 1173026003481 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 1173026003482 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173026003483 Walker A/P-loop; other site 1173026003484 ATP binding site [chemical binding]; other site 1173026003485 Q-loop/lid; other site 1173026003486 ABC transporter signature motif; other site 1173026003487 Walker B; other site 1173026003488 D-loop; other site 1173026003489 H-loop/switch region; other site 1173026003490 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1173026003491 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1173026003492 lipoprotein signal peptidase; Provisional; Region: PRK14787 1173026003493 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173026003494 phosphopeptide binding site; other site 1173026003495 Transglycosylase; Region: Transgly; pfam00912 1173026003496 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173026003497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173026003498 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 1173026003499 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 1173026003500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026003501 active site 1173026003502 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173026003503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026003504 dimer interface [polypeptide binding]; other site 1173026003505 conserved gate region; other site 1173026003506 putative PBP binding loops; other site 1173026003507 ABC-ATPase subunit interface; other site 1173026003508 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 1173026003509 Ycf46; Provisional; Region: ycf46; CHL00195 1173026003510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026003511 Walker A motif; other site 1173026003512 ATP binding site [chemical binding]; other site 1173026003513 Walker B motif; other site 1173026003514 arginine finger; other site 1173026003515 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 1173026003516 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026003517 NAD binding site [chemical binding]; other site 1173026003518 substrate binding site [chemical binding]; other site 1173026003519 active site 1173026003520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026003521 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1173026003522 DNA repair protein RadA; Provisional; Region: PRK11823 1173026003523 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1173026003524 Walker A motif/ATP binding site; other site 1173026003525 ATP binding site [chemical binding]; other site 1173026003526 Walker B motif; other site 1173026003527 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173026003528 Ycf27; Reviewed; Region: orf27; CHL00148 1173026003529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003530 active site 1173026003531 phosphorylation site [posttranslational modification] 1173026003532 intermolecular recognition site; other site 1173026003533 dimerization interface [polypeptide binding]; other site 1173026003534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026003535 DNA binding site [nucleotide binding] 1173026003536 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 1173026003537 Protein of unknown function (DUF456); Region: DUF456; cl01069 1173026003538 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173026003539 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173026003540 catalytic residues [active] 1173026003541 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173026003542 catalytic residues [active] 1173026003543 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026003544 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026003545 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1173026003546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026003547 dimerization interface [polypeptide binding]; other site 1173026003548 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026003549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026003550 putative active site [active] 1173026003551 heme pocket [chemical binding]; other site 1173026003552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026003553 dimer interface [polypeptide binding]; other site 1173026003554 phosphorylation site [posttranslational modification] 1173026003555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026003556 ATP binding site [chemical binding]; other site 1173026003557 Mg2+ binding site [ion binding]; other site 1173026003558 G-X-G motif; other site 1173026003559 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1173026003560 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1173026003561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1173026003562 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1173026003563 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 1173026003564 DNA photolyase; Region: DNA_photolyase; pfam00875 1173026003565 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1173026003566 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1173026003567 nudix motif; other site 1173026003568 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1173026003569 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173026003570 dimer interface [polypeptide binding]; other site 1173026003571 ADP-ribose binding site [chemical binding]; other site 1173026003572 active site 1173026003573 nudix motif; other site 1173026003574 metal binding site [ion binding]; metal-binding site 1173026003575 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1173026003576 catalytic center binding site [active] 1173026003577 ATP binding site [chemical binding]; other site 1173026003578 Transglycosylase; Region: Transgly; pfam00912 1173026003579 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173026003580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173026003581 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173026003582 metal binding site [ion binding]; metal-binding site 1173026003583 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1173026003584 16S rRNA methyltransferase B; Provisional; Region: PRK14901 1173026003585 putative RNA binding site [nucleotide binding]; other site 1173026003586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026003587 S-adenosylmethionine binding site [chemical binding]; other site 1173026003588 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173026003589 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1173026003590 Di-iron ligands [ion binding]; other site 1173026003591 PemK-like protein; Region: PemK; pfam02452 1173026003592 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1173026003593 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 1173026003594 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 1173026003595 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1173026003596 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1173026003597 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 1173026003598 active site 1173026003599 metal binding site [ion binding]; metal-binding site 1173026003600 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 1173026003601 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173026003602 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1173026003603 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1173026003604 active site 1173026003605 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173026003606 CHAT domain; Region: CHAT; cl17868 1173026003607 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173026003608 CHASE2 domain; Region: CHASE2; pfam05226 1173026003609 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173026003610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026003611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026003612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173026003613 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173026003614 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173026003615 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173026003616 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173026003617 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1173026003618 FAD binding pocket [chemical binding]; other site 1173026003619 conserved FAD binding motif [chemical binding]; other site 1173026003620 phosphate binding motif [ion binding]; other site 1173026003621 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 1173026003622 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173026003623 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1173026003624 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 1173026003625 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1173026003626 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1173026003627 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 1173026003628 4Fe-4S binding domain; Region: Fer4; pfam00037 1173026003629 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 1173026003630 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1173026003631 citrate synthase; Provisional; Region: PRK14036 1173026003632 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 1173026003633 dimer interface [polypeptide binding]; other site 1173026003634 active site 1173026003635 citrylCoA binding site [chemical binding]; other site 1173026003636 oxalacetate/citrate binding site [chemical binding]; other site 1173026003637 coenzyme A binding site [chemical binding]; other site 1173026003638 catalytic triad [active] 1173026003639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026003640 catalytic core [active] 1173026003641 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1173026003642 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173026003643 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173026003644 active site 1173026003645 alanine racemase; Reviewed; Region: alr; PRK00053 1173026003646 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1173026003647 active site 1173026003648 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173026003649 dimer interface [polypeptide binding]; other site 1173026003650 substrate binding site [chemical binding]; other site 1173026003651 catalytic residues [active] 1173026003652 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1173026003653 metal binding site [ion binding]; metal-binding site 1173026003654 YjzC-like protein; Region: YjzC; pfam14168 1173026003655 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173026003656 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173026003657 putative ADP-binding pocket [chemical binding]; other site 1173026003658 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173026003659 RNA recognition motif; Region: RRM; smart00360 1173026003660 TPR repeat; Region: TPR_11; pfam13414 1173026003661 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173026003662 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173026003663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026003664 active site 1173026003665 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 1173026003666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026003667 Walker A motif; other site 1173026003668 ATP binding site [chemical binding]; other site 1173026003669 PemK-like protein; Region: PemK; pfam02452 1173026003670 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1173026003671 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1173026003672 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1173026003673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026003674 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173026003675 dimer interface [polypeptide binding]; other site 1173026003676 [2Fe-2S] cluster binding site [ion binding]; other site 1173026003677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026003678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003679 active site 1173026003680 phosphorylation site [posttranslational modification] 1173026003681 intermolecular recognition site; other site 1173026003682 dimerization interface [polypeptide binding]; other site 1173026003683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026003684 DNA binding residues [nucleotide binding] 1173026003685 dimerization interface [polypeptide binding]; other site 1173026003686 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173026003687 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173026003688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026003689 dimer interface [polypeptide binding]; other site 1173026003690 conserved gate region; other site 1173026003691 putative PBP binding loops; other site 1173026003692 ABC-ATPase subunit interface; other site 1173026003693 sulfate transport protein; Provisional; Region: cysT; CHL00187 1173026003694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026003695 dimer interface [polypeptide binding]; other site 1173026003696 conserved gate region; other site 1173026003697 putative PBP binding loops; other site 1173026003698 ABC-ATPase subunit interface; other site 1173026003699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026003700 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173026003701 Ubiquitin-like proteins; Region: UBQ; cl00155 1173026003702 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1173026003703 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1173026003704 putative dimer interface [polypeptide binding]; other site 1173026003705 putative anticodon binding site; other site 1173026003706 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1173026003707 homodimer interface [polypeptide binding]; other site 1173026003708 motif 1; other site 1173026003709 motif 2; other site 1173026003710 active site 1173026003711 motif 3; other site 1173026003712 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1173026003713 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1173026003714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1173026003715 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026003716 putative active site [active] 1173026003717 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1173026003718 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1173026003719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026003720 S-adenosylmethionine binding site [chemical binding]; other site 1173026003721 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026003722 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 1173026003723 Maf-like protein; Region: Maf; pfam02545 1173026003724 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1173026003725 active site 1173026003726 dimer interface [polypeptide binding]; other site 1173026003727 PsbP; Region: PsbP; pfam01789 1173026003728 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1173026003729 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1173026003730 AIR carboxylase; Region: AIRC; smart01001 1173026003731 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173026003732 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173026003733 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026003734 putative active site [active] 1173026003735 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173026003736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 1173026003737 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1173026003738 Strictosidine synthase; Region: Str_synth; pfam03088 1173026003739 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1173026003740 homotrimer interaction site [polypeptide binding]; other site 1173026003741 zinc binding site [ion binding]; other site 1173026003742 CDP-binding sites; other site 1173026003743 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1173026003744 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1173026003745 proposed catalytic triad [active] 1173026003746 active site nucleophile [active] 1173026003747 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 1173026003748 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026003749 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026003750 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026003751 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173026003752 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1173026003753 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026003754 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026003755 active site 1173026003756 ATP binding site [chemical binding]; other site 1173026003757 substrate binding site [chemical binding]; other site 1173026003758 activation loop (A-loop); other site 1173026003759 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173026003760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026003761 S-adenosylmethionine binding site [chemical binding]; other site 1173026003762 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1173026003763 phosphatidate cytidylyltransferase; Region: PLN02953 1173026003764 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026003765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026003766 active site 1173026003767 phosphorylation site [posttranslational modification] 1173026003768 intermolecular recognition site; other site 1173026003769 dimerization interface [polypeptide binding]; other site 1173026003770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026003771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026003772 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026003773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003774 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003775 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026003776 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003777 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003778 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026003779 AAA ATPase domain; Region: AAA_16; pfam13191 1173026003780 NACHT domain; Region: NACHT; pfam05729 1173026003781 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026003782 WD40 repeats; Region: WD40; smart00320 1173026003783 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026003784 structural tetrad; other site 1173026003785 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026003786 structural tetrad; other site 1173026003787 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1173026003788 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026003789 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026003790 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1173026003791 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026003792 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026003793 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173026003794 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1173026003795 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173026003796 RNA binding surface [nucleotide binding]; other site 1173026003797 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1173026003798 active site 1173026003799 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1173026003800 Helix-turn-helix domain; Region: HTH_25; pfam13413 1173026003801 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1173026003802 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1173026003803 sulfotransferase; Region: PLN02164 1173026003804 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173026003805 nudix motif; other site 1173026003806 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1173026003807 homotrimer interaction site [polypeptide binding]; other site 1173026003808 putative active site [active] 1173026003809 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1173026003810 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1173026003811 Na binding site [ion binding]; other site 1173026003812 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 1173026003813 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173026003814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026003815 ATP binding site [chemical binding]; other site 1173026003816 putative Mg++ binding site [ion binding]; other site 1173026003817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026003818 nucleotide binding region [chemical binding]; other site 1173026003819 ATP-binding site [chemical binding]; other site 1173026003820 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173026003821 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1173026003822 metal ion-dependent adhesion site (MIDAS); other site 1173026003823 Predicted membrane protein [Function unknown]; Region: COG3431 1173026003824 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1173026003825 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1173026003826 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1173026003827 dimer interface [polypeptide binding]; other site 1173026003828 motif 1; other site 1173026003829 active site 1173026003830 motif 2; other site 1173026003831 motif 3; other site 1173026003832 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1173026003833 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1173026003834 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1173026003835 active site 1173026003836 Riboflavin kinase; Region: Flavokinase; pfam01687 1173026003837 MoxR-like ATPases [General function prediction only]; Region: COG0714 1173026003838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026003839 Walker A motif; other site 1173026003840 ATP binding site [chemical binding]; other site 1173026003841 Walker B motif; other site 1173026003842 arginine finger; other site 1173026003843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026003844 S-adenosylmethionine binding site [chemical binding]; other site 1173026003845 Dihaem cytochrome c; Region: DHC; pfam09626 1173026003846 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 1173026003847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173026003848 ATP binding site [chemical binding]; other site 1173026003849 putative Mg++ binding site [ion binding]; other site 1173026003850 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1173026003851 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1173026003852 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173026003853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026003854 Coenzyme A binding pocket [chemical binding]; other site 1173026003855 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173026003856 putative active site pocket [active] 1173026003857 dimerization interface [polypeptide binding]; other site 1173026003858 putative catalytic residue [active] 1173026003859 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1173026003860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026003861 DNA-binding site [nucleotide binding]; DNA binding site 1173026003862 FCD domain; Region: FCD; pfam07729 1173026003863 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173026003864 EamA-like transporter family; Region: EamA; pfam00892 1173026003865 EamA-like transporter family; Region: EamA; pfam00892 1173026003866 allantoate amidohydrolase; Reviewed; Region: PRK09290 1173026003867 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1173026003868 active site 1173026003869 metal binding site [ion binding]; metal-binding site 1173026003870 dimer interface [polypeptide binding]; other site 1173026003871 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173026003872 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173026003873 active site 1173026003874 putative substrate binding region [chemical binding]; other site 1173026003875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1173026003876 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173026003877 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173026003878 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026003879 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026003880 active site 1173026003881 Chain length determinant protein; Region: Wzz; pfam02706 1173026003882 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026003883 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1173026003884 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173026003885 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026003886 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173026003887 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026003888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026003889 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 1173026003890 putative ADP-binding pocket [chemical binding]; other site 1173026003891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026003892 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1173026003893 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1173026003894 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1173026003895 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1173026003896 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1173026003897 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173026003898 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1173026003899 substrate binding site; other site 1173026003900 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1173026003901 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173026003902 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1173026003903 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173026003904 extended (e) SDRs; Region: SDR_e; cd08946 1173026003905 NAD(P) binding site [chemical binding]; other site 1173026003906 active site 1173026003907 substrate binding site [chemical binding]; other site 1173026003908 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1173026003909 metal binding site [ion binding]; metal-binding site 1173026003910 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1173026003911 putative metal binding site [ion binding]; other site 1173026003912 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1173026003913 active site 1173026003914 catalytic triad [active] 1173026003915 oxyanion hole [active] 1173026003916 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1173026003917 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026003918 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1173026003919 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1173026003920 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1173026003921 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1173026003922 putative active site [active] 1173026003923 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1173026003924 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1173026003925 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1173026003926 Ligand binding site; other site 1173026003927 oligomer interface; other site 1173026003928 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173026003929 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026003930 putative trimer interface [polypeptide binding]; other site 1173026003931 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026003932 trimer interface [polypeptide binding]; other site 1173026003933 active site 1173026003934 substrate binding site [chemical binding]; other site 1173026003935 putative CoA binding site [chemical binding]; other site 1173026003936 CoA binding site [chemical binding]; other site 1173026003937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026003938 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1173026003939 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1173026003940 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1173026003941 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1173026003942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026003943 active site 1173026003944 motif I; other site 1173026003945 motif II; other site 1173026003946 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173026003947 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173026003948 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1173026003949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026003950 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026003951 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173026003952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026003953 active site 1173026003954 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026003955 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026003956 trimer interface [polypeptide binding]; other site 1173026003957 active site 1173026003958 substrate binding site [chemical binding]; other site 1173026003959 CoA binding site [chemical binding]; other site 1173026003960 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026003961 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026003962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026003963 Walker A/P-loop; other site 1173026003964 ATP binding site [chemical binding]; other site 1173026003965 Q-loop/lid; other site 1173026003966 ABC transporter signature motif; other site 1173026003967 Walker B; other site 1173026003968 D-loop; other site 1173026003969 H-loop/switch region; other site 1173026003970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026003971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026003972 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173026003973 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173026003974 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1173026003975 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173026003976 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1173026003977 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173026003978 putative ADP-binding pocket [chemical binding]; other site 1173026003979 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026003980 active site 1173026003981 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173026003982 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 1173026003983 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1173026003984 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1173026003985 active sites [active] 1173026003986 tetramer interface [polypeptide binding]; other site 1173026003987 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1173026003988 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1173026003989 acyl-activating enzyme (AAE) consensus motif; other site 1173026003990 putative AMP binding site [chemical binding]; other site 1173026003991 putative active site [active] 1173026003992 putative CoA binding site [chemical binding]; other site 1173026003993 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026003994 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173026003995 GAF domain; Region: GAF; pfam01590 1173026003996 GAF domain; Region: GAF_2; pfam13185 1173026003997 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1173026003998 active site 1173026003999 catalytic triad [active] 1173026004000 oxyanion hole [active] 1173026004001 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026004002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026004003 active site 1173026004004 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1173026004005 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026004006 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1173026004007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026004008 active site 1173026004009 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1173026004010 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1173026004011 active site 1173026004012 homodimer interface [polypeptide binding]; other site 1173026004013 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026004014 putative active site [active] 1173026004015 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1173026004016 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173026004017 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173026004018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173026004019 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 1173026004020 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026004021 catalytic residues [active] 1173026004022 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1173026004023 4Fe-4S binding domain; Region: Fer4; pfam00037 1173026004024 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1173026004025 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173026004026 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1173026004027 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026004028 catalytic residue [active] 1173026004029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026004030 ATP binding site [chemical binding]; other site 1173026004031 Mg2+ binding site [ion binding]; other site 1173026004032 G-X-G motif; other site 1173026004033 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173026004034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026004035 ATP binding site [chemical binding]; other site 1173026004036 putative Mg++ binding site [ion binding]; other site 1173026004037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026004038 nucleotide binding region [chemical binding]; other site 1173026004039 ATP-binding site [chemical binding]; other site 1173026004040 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173026004041 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1173026004042 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173026004043 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1173026004044 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 1173026004045 Uncharacterized conserved protein [Function unknown]; Region: COG5607 1173026004046 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 1173026004047 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1173026004048 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 1173026004049 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 1173026004050 P-loop; other site 1173026004051 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026004052 GAF domain; Region: GAF; pfam01590 1173026004053 Phytochrome region; Region: PHY; pfam00360 1173026004054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026004055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026004056 metal binding site [ion binding]; metal-binding site 1173026004057 active site 1173026004058 I-site; other site 1173026004059 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026004060 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 1173026004061 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026004062 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026004063 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173026004064 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026004065 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026004066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026004067 Walker A motif; other site 1173026004068 ATP binding site [chemical binding]; other site 1173026004069 Walker B motif; other site 1173026004070 arginine finger; other site 1173026004071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026004072 Walker A motif; other site 1173026004073 ATP binding site [chemical binding]; other site 1173026004074 Walker B motif; other site 1173026004075 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173026004076 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173026004077 hydrophobic ligand binding site; other site 1173026004078 ChaB; Region: ChaB; pfam06150 1173026004079 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1173026004080 putative active site [active] 1173026004081 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1173026004082 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1173026004083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026004084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173026004085 flavoprotein, HI0933 family; Region: TIGR00275 1173026004086 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1173026004087 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1173026004088 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1173026004089 trimer interface [polypeptide binding]; other site 1173026004090 active site 1173026004091 UDP-GlcNAc binding site [chemical binding]; other site 1173026004092 lipid binding site [chemical binding]; lipid-binding site 1173026004093 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173026004094 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173026004095 putative dimer interface [polypeptide binding]; other site 1173026004096 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1173026004097 Cysteine-rich domain; Region: CCG; pfam02754 1173026004098 Cysteine-rich domain; Region: CCG; pfam02754 1173026004099 acyl carrier protein; Provisional; Region: acpP; PRK00982 1173026004100 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1173026004101 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173026004102 dimer interface [polypeptide binding]; other site 1173026004103 active site 1173026004104 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1173026004105 transketolase; Region: PLN02790 1173026004106 TPP-binding site [chemical binding]; other site 1173026004107 dimer interface [polypeptide binding]; other site 1173026004108 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1173026004109 PYR/PP interface [polypeptide binding]; other site 1173026004110 dimer interface [polypeptide binding]; other site 1173026004111 TPP binding site [chemical binding]; other site 1173026004112 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173026004113 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1173026004114 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1173026004115 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 1173026004116 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173026004117 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173026004118 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173026004119 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1173026004120 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1173026004121 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1173026004122 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1173026004123 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026004124 N-terminal plug; other site 1173026004125 ligand-binding site [chemical binding]; other site 1173026004126 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173026004127 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173026004128 intersubunit interface [polypeptide binding]; other site 1173026004129 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173026004130 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173026004131 Predicted transcriptional regulator [Transcription]; Region: COG3682 1173026004132 cytochrome c6; Provisional; Region: PRK13697 1173026004133 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173026004134 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1173026004135 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026004136 N-terminal plug; other site 1173026004137 ligand-binding site [chemical binding]; other site 1173026004138 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173026004139 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1173026004140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173026004141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026004142 dimer interface [polypeptide binding]; other site 1173026004143 conserved gate region; other site 1173026004144 putative PBP binding loops; other site 1173026004145 ABC-ATPase subunit interface; other site 1173026004146 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173026004147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173026004148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026004149 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 1173026004150 catalytic residues [active] 1173026004151 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026004152 putative active site [active] 1173026004153 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026004154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004155 S-adenosylmethionine binding site [chemical binding]; other site 1173026004156 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173026004157 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026004158 active site 1173026004159 NTP binding site [chemical binding]; other site 1173026004160 metal binding triad [ion binding]; metal-binding site 1173026004161 antibiotic binding site [chemical binding]; other site 1173026004162 PIN domain; Region: PIN_3; pfam13470 1173026004163 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 1173026004164 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173026004165 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1173026004166 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1173026004167 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 1173026004168 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173026004169 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173026004170 phosphopeptide binding site; other site 1173026004171 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026004172 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026004173 active site 1173026004174 ATP binding site [chemical binding]; other site 1173026004175 substrate binding site [chemical binding]; other site 1173026004176 activation loop (A-loop); other site 1173026004177 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 1173026004178 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1173026004179 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173026004180 active site 1173026004181 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1173026004182 pseudouridine synthase; Region: TIGR00093 1173026004183 active site 1173026004184 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026004185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004186 S-adenosylmethionine binding site [chemical binding]; other site 1173026004187 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026004188 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173026004189 Trm112p-like protein; Region: Trm112p; cl01066 1173026004190 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026004191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004192 S-adenosylmethionine binding site [chemical binding]; other site 1173026004193 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1173026004194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026004195 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173026004196 NACHT domain; Region: NACHT; pfam05729 1173026004197 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173026004198 structural tetrad; other site 1173026004199 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026004200 structural tetrad; other site 1173026004201 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026004202 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026004203 structural tetrad; other site 1173026004204 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1173026004205 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1173026004206 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173026004207 anti sigma factor interaction site; other site 1173026004208 regulatory phosphorylation site [posttranslational modification]; other site 1173026004209 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173026004210 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026004211 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026004212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026004213 active site 1173026004214 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026004215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026004216 active site 1173026004217 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026004218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026004219 active site 1173026004220 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1173026004221 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1173026004222 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026004223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026004224 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173026004225 Walker A/P-loop; other site 1173026004226 ATP binding site [chemical binding]; other site 1173026004227 Q-loop/lid; other site 1173026004228 ABC transporter signature motif; other site 1173026004229 Walker B; other site 1173026004230 D-loop; other site 1173026004231 H-loop/switch region; other site 1173026004232 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1173026004233 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1173026004234 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026004235 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173026004236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004237 S-adenosylmethionine binding site [chemical binding]; other site 1173026004238 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1173026004239 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1173026004240 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173026004241 putative ADP-binding pocket [chemical binding]; other site 1173026004242 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026004243 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026004244 trimer interface [polypeptide binding]; other site 1173026004245 active site 1173026004246 substrate binding site [chemical binding]; other site 1173026004247 CoA binding site [chemical binding]; other site 1173026004248 GAF domain; Region: GAF; pfam01590 1173026004249 GAF domain; Region: GAF_2; pfam13185 1173026004250 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 1173026004251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026004252 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026004253 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026004254 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004256 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 1173026004257 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1173026004258 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1173026004259 active site 1173026004260 Zn binding site [ion binding]; other site 1173026004261 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026004262 GAF domain; Region: GAF; pfam01590 1173026004263 PAS domain S-box; Region: sensory_box; TIGR00229 1173026004264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026004265 putative active site [active] 1173026004266 heme pocket [chemical binding]; other site 1173026004267 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1173026004268 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173026004269 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026004270 putative binding surface; other site 1173026004271 active site 1173026004272 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1173026004273 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1173026004274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026004275 ATP binding site [chemical binding]; other site 1173026004276 Mg2+ binding site [ion binding]; other site 1173026004277 G-X-G motif; other site 1173026004278 Two component signalling adaptor domain; Region: CheW; smart00260 1173026004279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026004280 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026004281 active site 1173026004282 phosphorylation site [posttranslational modification] 1173026004283 intermolecular recognition site; other site 1173026004284 dimerization interface [polypeptide binding]; other site 1173026004285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026004286 dimerization interface [polypeptide binding]; other site 1173026004287 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026004288 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026004289 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173026004290 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173026004291 dimer interface [polypeptide binding]; other site 1173026004292 putative CheW interface [polypeptide binding]; other site 1173026004293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026004294 dimerization interface [polypeptide binding]; other site 1173026004295 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026004296 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026004297 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173026004298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173026004299 dimer interface [polypeptide binding]; other site 1173026004300 putative CheW interface [polypeptide binding]; other site 1173026004301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026004302 dimerization interface [polypeptide binding]; other site 1173026004303 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026004304 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026004305 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1173026004306 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1173026004307 dimer interface [polypeptide binding]; other site 1173026004308 putative CheW interface [polypeptide binding]; other site 1173026004309 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1173026004310 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026004311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026004312 active site 1173026004313 phosphorylation site [posttranslational modification] 1173026004314 intermolecular recognition site; other site 1173026004315 dimerization interface [polypeptide binding]; other site 1173026004316 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026004317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026004318 active site 1173026004319 phosphorylation site [posttranslational modification] 1173026004320 intermolecular recognition site; other site 1173026004321 dimerization interface [polypeptide binding]; other site 1173026004322 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026004323 Ligand Binding Site [chemical binding]; other site 1173026004324 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1173026004325 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1173026004326 putative NAD(P) binding site [chemical binding]; other site 1173026004327 active site 1173026004328 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173026004329 putative active site pocket [active] 1173026004330 dimerization interface [polypeptide binding]; other site 1173026004331 putative catalytic residue [active] 1173026004332 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1173026004333 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1173026004334 glycogen binding site [chemical binding]; other site 1173026004335 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1173026004336 active site 1173026004337 catalytic site [active] 1173026004338 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173026004339 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 1173026004340 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1173026004341 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1173026004342 proposed catalytic triad [active] 1173026004343 active site nucleophile [active] 1173026004344 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173026004345 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173026004346 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1173026004347 16S/18S rRNA binding site [nucleotide binding]; other site 1173026004348 S13e-L30e interaction site [polypeptide binding]; other site 1173026004349 25S rRNA binding site [nucleotide binding]; other site 1173026004350 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 1173026004351 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 1173026004352 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1173026004353 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173026004354 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173026004355 putative dimer interface [polypeptide binding]; other site 1173026004356 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1173026004357 Permease; Region: Permease; cl00510 1173026004358 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 1173026004359 Uso1 / p115 like vesicle tethering protein, C terminal region; Region: Uso1_p115_C; pfam04871 1173026004360 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 1173026004361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004362 S-adenosylmethionine binding site [chemical binding]; other site 1173026004363 membrane protein; Provisional; Region: PRK14419 1173026004364 GTP-binding protein Der; Reviewed; Region: PRK00093 1173026004365 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1173026004366 G1 box; other site 1173026004367 GTP/Mg2+ binding site [chemical binding]; other site 1173026004368 Switch I region; other site 1173026004369 G2 box; other site 1173026004370 Switch II region; other site 1173026004371 G3 box; other site 1173026004372 G4 box; other site 1173026004373 G5 box; other site 1173026004374 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1173026004375 G1 box; other site 1173026004376 GTP/Mg2+ binding site [chemical binding]; other site 1173026004377 Switch I region; other site 1173026004378 G2 box; other site 1173026004379 G3 box; other site 1173026004380 Switch II region; other site 1173026004381 G4 box; other site 1173026004382 G5 box; other site 1173026004383 Cobalt transport protein; Region: CbiQ; pfam02361 1173026004384 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1173026004385 anthranilate synthase component I; Provisional; Region: PRK13569 1173026004386 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173026004387 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1173026004388 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 1173026004389 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1173026004390 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173026004391 catalytic residue [active] 1173026004392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1173026004393 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1173026004394 pyrroline-5-carboxylate reductase; Region: PLN02688 1173026004395 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173026004396 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026004397 ATP binding site [chemical binding]; other site 1173026004398 putative Mg++ binding site [ion binding]; other site 1173026004399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026004400 nucleotide binding region [chemical binding]; other site 1173026004401 ATP-binding site [chemical binding]; other site 1173026004402 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 1173026004403 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1173026004404 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1173026004405 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1173026004406 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1173026004407 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1173026004408 tetramer interface [polypeptide binding]; other site 1173026004409 heme binding pocket [chemical binding]; other site 1173026004410 NADPH binding site [chemical binding]; other site 1173026004411 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026004412 putative active site [active] 1173026004413 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173026004414 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173026004415 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173026004416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026004417 FeS/SAM binding site; other site 1173026004418 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 1173026004419 HD domain; Region: HD_5; pfam13487 1173026004420 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026004421 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004422 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004423 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026004424 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004426 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026004427 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1173026004428 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1173026004429 CAAX protease self-immunity; Region: Abi; pfam02517 1173026004430 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1173026004431 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173026004432 anti sigma factor interaction site; other site 1173026004433 regulatory phosphorylation site [posttranslational modification]; other site 1173026004434 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1173026004435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026004436 FeS/SAM binding site; other site 1173026004437 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 1173026004438 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1173026004439 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1173026004440 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1173026004441 homodimer interface [polypeptide binding]; other site 1173026004442 oligonucleotide binding site [chemical binding]; other site 1173026004443 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1173026004444 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173026004445 active site 1173026004446 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173026004447 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173026004448 Extensin-like region; Region: Extensin_2; pfam04554 1173026004449 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173026004450 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173026004451 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026004452 Walker A/P-loop; other site 1173026004453 ATP binding site [chemical binding]; other site 1173026004454 Q-loop/lid; other site 1173026004455 ABC transporter signature motif; other site 1173026004456 Walker B; other site 1173026004457 D-loop; other site 1173026004458 H-loop/switch region; other site 1173026004459 DevC protein; Region: devC; TIGR01185 1173026004460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026004461 FtsX-like permease family; Region: FtsX; pfam02687 1173026004462 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173026004463 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1173026004464 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026004465 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1173026004466 ParB-like nuclease domain; Region: ParB; smart00470 1173026004467 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173026004468 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1173026004469 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026004470 active site 1173026004471 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173026004472 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173026004473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026004474 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173026004475 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173026004476 putative NADP binding site [chemical binding]; other site 1173026004477 active site 1173026004478 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1173026004479 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1173026004480 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026004481 active site 1173026004482 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1173026004483 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1173026004484 FMN binding site [chemical binding]; other site 1173026004485 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1173026004486 substrate binding site [chemical binding]; other site 1173026004487 putative catalytic residue [active] 1173026004488 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173026004489 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1173026004490 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1173026004491 putative NAD(P) binding site [chemical binding]; other site 1173026004492 active site 1173026004493 putative substrate binding site [chemical binding]; other site 1173026004494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173026004495 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026004496 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1173026004497 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173026004498 Walker A/P-loop; other site 1173026004499 ATP binding site [chemical binding]; other site 1173026004500 Q-loop/lid; other site 1173026004501 ABC transporter signature motif; other site 1173026004502 Walker B; other site 1173026004503 D-loop; other site 1173026004504 H-loop/switch region; other site 1173026004505 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1173026004506 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1173026004507 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026004508 active site 1173026004509 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173026004510 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173026004511 NAD(P) binding site [chemical binding]; other site 1173026004512 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004513 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004514 TIGR03032 family protein; Region: TIGR03032 1173026004515 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173026004516 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173026004517 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1173026004518 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1173026004519 SLBB domain; Region: SLBB; pfam10531 1173026004520 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026004521 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173026004522 Walker A/P-loop; other site 1173026004523 ATP binding site [chemical binding]; other site 1173026004524 Q-loop/lid; other site 1173026004525 ABC transporter signature motif; other site 1173026004526 Walker B; other site 1173026004527 D-loop; other site 1173026004528 H-loop/switch region; other site 1173026004529 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1173026004530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026004531 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173026004532 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1173026004533 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173026004534 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026004535 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026004536 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1173026004537 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173026004538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026004539 dimer interface [polypeptide binding]; other site 1173026004540 conserved gate region; other site 1173026004541 putative PBP binding loops; other site 1173026004542 ABC-ATPase subunit interface; other site 1173026004543 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1173026004544 Glycoprotease family; Region: Peptidase_M22; pfam00814 1173026004545 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 1173026004546 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1173026004547 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1173026004548 active site 1173026004549 NTP binding site [chemical binding]; other site 1173026004550 metal binding triad [ion binding]; metal-binding site 1173026004551 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1173026004552 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1173026004553 glutathione reductase; Validated; Region: PRK06116 1173026004554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026004555 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026004556 glutathione reductase; Validated; Region: PRK06116 1173026004557 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1173026004558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026004559 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026004560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026004561 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1173026004562 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 1173026004563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026004564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026004565 homodimer interface [polypeptide binding]; other site 1173026004566 catalytic residue [active] 1173026004567 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026004568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026004569 Coenzyme A binding pocket [chemical binding]; other site 1173026004570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173026004571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026004572 dimer interface [polypeptide binding]; other site 1173026004573 conserved gate region; other site 1173026004574 putative PBP binding loops; other site 1173026004575 ABC-ATPase subunit interface; other site 1173026004576 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 1173026004577 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173026004578 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1173026004579 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1173026004580 Walker A/P-loop; other site 1173026004581 ATP binding site [chemical binding]; other site 1173026004582 Q-loop/lid; other site 1173026004583 ABC transporter signature motif; other site 1173026004584 Walker B; other site 1173026004585 D-loop; other site 1173026004586 H-loop/switch region; other site 1173026004587 TOBE-like domain; Region: TOBE_3; pfam12857 1173026004588 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173026004589 geranylgeranyl reductase; Region: ChlP; TIGR02028 1173026004590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026004591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026004592 active site 1173026004593 phosphorylation site [posttranslational modification] 1173026004594 intermolecular recognition site; other site 1173026004595 dimerization interface [polypeptide binding]; other site 1173026004596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026004597 DNA binding site [nucleotide binding] 1173026004598 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1173026004599 Predicted membrane protein [Function unknown]; Region: COG4325 1173026004600 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1173026004601 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173026004602 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173026004603 Predicted membrane protein [Function unknown]; Region: COG1808 1173026004604 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173026004605 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173026004606 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026004607 putative active site [active] 1173026004608 putative metal binding site [ion binding]; other site 1173026004609 Predicted membrane protein [Function unknown]; Region: COG1808 1173026004610 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1173026004611 Sm and related proteins; Region: Sm_like; cl00259 1173026004612 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1173026004613 putative oligomer interface [polypeptide binding]; other site 1173026004614 putative RNA binding site [nucleotide binding]; other site 1173026004615 NusA N-terminal domain; Region: NusA_N; pfam08529 1173026004616 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1173026004617 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1173026004618 RNA binding site [nucleotide binding]; other site 1173026004619 homodimer interface [polypeptide binding]; other site 1173026004620 NusA-like KH domain; Region: KH_5; pfam13184 1173026004621 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1173026004622 G-X-X-G motif; other site 1173026004623 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1173026004624 putative RNA binding cleft [nucleotide binding]; other site 1173026004625 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173026004626 translation initiation factor IF-2; Region: IF-2; TIGR00487 1173026004627 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1173026004628 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1173026004629 G1 box; other site 1173026004630 putative GEF interaction site [polypeptide binding]; other site 1173026004631 GTP/Mg2+ binding site [chemical binding]; other site 1173026004632 Switch I region; other site 1173026004633 G2 box; other site 1173026004634 G3 box; other site 1173026004635 Switch II region; other site 1173026004636 G4 box; other site 1173026004637 G5 box; other site 1173026004638 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1173026004639 Translation-initiation factor 2; Region: IF-2; pfam11987 1173026004640 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1173026004641 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173026004642 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1173026004643 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1173026004644 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1173026004645 S-layer homology domain; Region: SLH; pfam00395 1173026004646 S-layer homology domain; Region: SLH; pfam00395 1173026004647 S-layer homology domain; Region: SLH; pfam00395 1173026004648 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 1173026004649 putative lipid kinase; Reviewed; Region: PRK00861 1173026004650 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173026004651 PEGA domain; Region: PEGA; pfam08308 1173026004652 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 1173026004653 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 1173026004654 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026004655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004656 S-adenosylmethionine binding site [chemical binding]; other site 1173026004657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026004658 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1173026004659 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026004661 active site 1173026004662 phosphorylation site [posttranslational modification] 1173026004663 intermolecular recognition site; other site 1173026004664 dimerization interface [polypeptide binding]; other site 1173026004665 polyphosphate kinase; Provisional; Region: PRK05443 1173026004666 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1173026004667 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1173026004668 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1173026004669 putative domain interface [polypeptide binding]; other site 1173026004670 putative active site [active] 1173026004671 catalytic site [active] 1173026004672 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1173026004673 putative domain interface [polypeptide binding]; other site 1173026004674 putative active site [active] 1173026004675 catalytic site [active] 1173026004676 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173026004677 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173026004678 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173026004679 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 1173026004680 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1173026004681 active site 1173026004682 ATP-binding site [chemical binding]; other site 1173026004683 pantoate-binding site; other site 1173026004684 HXXH motif; other site 1173026004685 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1173026004686 CMP-binding site; other site 1173026004687 The sites determining sugar specificity; other site 1173026004688 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1173026004689 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1173026004690 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1173026004691 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1173026004692 dimerization interface [polypeptide binding]; other site 1173026004693 putative ATP binding site [chemical binding]; other site 1173026004694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004695 S-adenosylmethionine binding site [chemical binding]; other site 1173026004696 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1173026004697 nucleotide binding site/active site [active] 1173026004698 HIT family signature motif; other site 1173026004699 catalytic residue [active] 1173026004700 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1173026004701 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1173026004702 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1173026004703 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1173026004704 putative NAD(P) binding site [chemical binding]; other site 1173026004705 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026004706 extended (e) SDRs; Region: SDR_e; cd08946 1173026004707 NAD(P) binding site [chemical binding]; other site 1173026004708 active site 1173026004709 substrate binding site [chemical binding]; other site 1173026004710 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 1173026004711 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1173026004712 active site 1173026004713 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173026004714 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173026004715 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173026004716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004717 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026004718 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004719 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026004720 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026004721 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173026004722 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1173026004723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026004724 active site 1173026004725 metal binding site [ion binding]; metal-binding site 1173026004726 hexamer interface [polypeptide binding]; other site 1173026004727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026004728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026004729 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1173026004730 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1173026004731 potential catalytic triad [active] 1173026004732 conserved cys residue [active] 1173026004733 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173026004734 protein I interface; other site 1173026004735 D2 interface; other site 1173026004736 protein T interface; other site 1173026004737 chlorophyll binding site; other site 1173026004738 beta carotene binding site; other site 1173026004739 pheophytin binding site; other site 1173026004740 manganese-stabilizing polypeptide interface; other site 1173026004741 CP43 interface; other site 1173026004742 protein L interface; other site 1173026004743 oxygen evolving complex binding site; other site 1173026004744 bromide binding site; other site 1173026004745 quinone binding site; other site 1173026004746 Fe binding site [ion binding]; other site 1173026004747 core light harvesting interface; other site 1173026004748 cytochrome b559 alpha subunit interface; other site 1173026004749 cytochrome c-550 interface; other site 1173026004750 protein J interface; other site 1173026004751 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173026004752 protein I interface; other site 1173026004753 D2 interface; other site 1173026004754 protein T interface; other site 1173026004755 chlorophyll binding site; other site 1173026004756 beta carotene binding site; other site 1173026004757 pheophytin binding site; other site 1173026004758 manganese-stabilizing polypeptide interface; other site 1173026004759 CP43 interface; other site 1173026004760 protein L interface; other site 1173026004761 oxygen evolving complex binding site; other site 1173026004762 bromide binding site; other site 1173026004763 quinone binding site; other site 1173026004764 Fe binding site [ion binding]; other site 1173026004765 core light harvesting interface; other site 1173026004766 cytochrome b559 alpha subunit interface; other site 1173026004767 cytochrome c-550 interface; other site 1173026004768 protein J interface; other site 1173026004769 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 1173026004770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026004771 FeS/SAM binding site; other site 1173026004772 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173026004773 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173026004774 C-terminal domain interface [polypeptide binding]; other site 1173026004775 GSH binding site (G-site) [chemical binding]; other site 1173026004776 dimer interface [polypeptide binding]; other site 1173026004777 Glutathione S-transferase, C-terminal domain; Region: GST_C; pfam00043 1173026004778 N-terminal domain interface [polypeptide binding]; other site 1173026004779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026004780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026004781 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1173026004782 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026004783 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1173026004784 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1173026004785 HflX GTPase family; Region: HflX; cd01878 1173026004786 G1 box; other site 1173026004787 GTP/Mg2+ binding site [chemical binding]; other site 1173026004788 Switch I region; other site 1173026004789 G2 box; other site 1173026004790 G3 box; other site 1173026004791 Switch II region; other site 1173026004792 G4 box; other site 1173026004793 G5 box; other site 1173026004794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1173026004795 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173026004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004797 S-adenosylmethionine binding site [chemical binding]; other site 1173026004798 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1173026004799 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1173026004800 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1173026004801 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1173026004802 NAD(P) binding site [chemical binding]; other site 1173026004803 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173026004804 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1173026004805 Family description; Region: UvrD_C_2; pfam13538 1173026004806 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1173026004807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026004808 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1173026004809 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1173026004810 putative active site [active] 1173026004811 Double zinc ribbon; Region: DZR; pfam12773 1173026004812 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1173026004813 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173026004814 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173026004815 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173026004816 phosphopeptide binding site; other site 1173026004817 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173026004818 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173026004819 phosphopeptide binding site; other site 1173026004820 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1173026004821 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026004822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026004823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026004824 AzlC protein; Region: AzlC; pfam03591 1173026004825 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 1173026004826 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 1173026004827 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173026004828 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173026004829 catalytic residues [active] 1173026004830 ribonuclease PH; Reviewed; Region: rph; PRK00173 1173026004831 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1173026004832 hexamer interface [polypeptide binding]; other site 1173026004833 active site 1173026004834 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1173026004835 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 1173026004836 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1173026004837 trimer interface [polypeptide binding]; other site 1173026004838 active site 1173026004839 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1173026004840 dimerization interface [polypeptide binding]; other site 1173026004841 active site 1173026004842 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 1173026004843 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1173026004844 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026004845 putative catalytic residue [active] 1173026004846 PRC-barrel domain; Region: PRC; pfam05239 1173026004847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173026004848 S-layer homology domain; Region: SLH; pfam00395 1173026004849 S-layer homology domain; Region: SLH; pfam00395 1173026004850 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1173026004851 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1173026004852 dimer interface [polypeptide binding]; other site 1173026004853 anticodon binding site; other site 1173026004854 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1173026004855 homodimer interface [polypeptide binding]; other site 1173026004856 motif 1; other site 1173026004857 active site 1173026004858 motif 2; other site 1173026004859 GAD domain; Region: GAD; pfam02938 1173026004860 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1173026004861 motif 3; other site 1173026004862 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1173026004863 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1173026004864 nitrilase; Region: PLN02798 1173026004865 putative active site [active] 1173026004866 catalytic triad [active] 1173026004867 dimer interface [polypeptide binding]; other site 1173026004868 Sulfocyanin (SoxE); Region: SoxE; cl17563 1173026004869 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1173026004870 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1173026004871 intersubunit interface [polypeptide binding]; other site 1173026004872 active site 1173026004873 zinc binding site [ion binding]; other site 1173026004874 Na+ binding site [ion binding]; other site 1173026004875 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 1173026004876 active site 1173026004877 catalytic residues [active] 1173026004878 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 1173026004879 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1173026004880 tetramer interface [polypeptide binding]; other site 1173026004881 TPP-binding site [chemical binding]; other site 1173026004882 heterodimer interface [polypeptide binding]; other site 1173026004883 phosphorylation loop region [posttranslational modification] 1173026004884 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026004885 HSP70 interaction site [polypeptide binding]; other site 1173026004886 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1173026004887 Predicted permeases [General function prediction only]; Region: COG0679 1173026004888 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1173026004889 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173026004890 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1173026004891 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1173026004892 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1173026004893 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1173026004894 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1173026004895 putative active site [active] 1173026004896 transaldolase; Provisional; Region: PRK03903 1173026004897 catalytic residue [active] 1173026004898 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1173026004899 AMP binding site [chemical binding]; other site 1173026004900 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1173026004901 metal binding site [ion binding]; metal-binding site 1173026004902 active site 1173026004903 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173026004904 ligand-binding site [chemical binding]; other site 1173026004905 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173026004906 magnesium chelatase subunit H; Provisional; Region: PRK12493 1173026004907 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173026004908 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1173026004909 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026004910 putative active site [active] 1173026004911 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026004912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026004913 S-adenosylmethionine binding site [chemical binding]; other site 1173026004914 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 1173026004915 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1173026004916 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1173026004917 putative di-iron ligands [ion binding]; other site 1173026004918 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173026004919 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026004920 Walker A/P-loop; other site 1173026004921 ATP binding site [chemical binding]; other site 1173026004922 Q-loop/lid; other site 1173026004923 ABC transporter signature motif; other site 1173026004924 Walker B; other site 1173026004925 D-loop; other site 1173026004926 H-loop/switch region; other site 1173026004927 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173026004928 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026004929 Walker A/P-loop; other site 1173026004930 ATP binding site [chemical binding]; other site 1173026004931 Q-loop/lid; other site 1173026004932 ABC transporter signature motif; other site 1173026004933 Walker B; other site 1173026004934 D-loop; other site 1173026004935 H-loop/switch region; other site 1173026004936 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1173026004937 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173026004938 Zn2+ binding site [ion binding]; other site 1173026004939 Mg2+ binding site [ion binding]; other site 1173026004940 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1173026004941 synthetase active site [active] 1173026004942 NTP binding site [chemical binding]; other site 1173026004943 metal binding site [ion binding]; metal-binding site 1173026004944 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1173026004945 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1173026004946 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004947 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004948 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004949 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004950 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026004951 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173026004952 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1173026004953 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026004954 ligand binding site [chemical binding]; other site 1173026004955 flexible hinge region; other site 1173026004956 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173026004957 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173026004958 putative active site [active] 1173026004959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026004960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026004961 Walker A/P-loop; other site 1173026004962 ATP binding site [chemical binding]; other site 1173026004963 Q-loop/lid; other site 1173026004964 ABC transporter signature motif; other site 1173026004965 Walker B; other site 1173026004966 D-loop; other site 1173026004967 H-loop/switch region; other site 1173026004968 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173026004969 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173026004970 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026004971 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1173026004972 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1173026004973 active site 1173026004974 SAM binding site [chemical binding]; other site 1173026004975 homodimer interface [polypeptide binding]; other site 1173026004976 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1173026004977 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 1173026004978 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1173026004979 ligand binding site [chemical binding]; other site 1173026004980 DNA polymerase III subunit beta; Validated; Region: PRK05643 1173026004981 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1173026004982 putative DNA binding surface [nucleotide binding]; other site 1173026004983 dimer interface [polypeptide binding]; other site 1173026004984 beta-clamp/clamp loader binding surface; other site 1173026004985 beta-clamp/translesion DNA polymerase binding surface; other site 1173026004986 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1173026004987 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1173026004988 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1173026004989 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173026004990 P loop; other site 1173026004991 Nucleotide binding site [chemical binding]; other site 1173026004992 DTAP/Switch II; other site 1173026004993 Switch I; other site 1173026004994 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173026004995 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1173026004996 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1173026004997 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1173026004998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1173026004999 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1173026005000 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1173026005001 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1173026005002 catalytic triad [active] 1173026005003 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026005004 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026005005 siderophore binding site; other site 1173026005006 AMIN domain; Region: AMIN; pfam11741 1173026005007 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005008 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005009 N-terminal plug; other site 1173026005010 ligand-binding site [chemical binding]; other site 1173026005011 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1173026005012 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026005013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005014 Predicted membrane protein [Function unknown]; Region: COG4270 1173026005015 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026005016 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026005017 Protein of unknown function DUF99; Region: DUF99; pfam01949 1173026005018 hypothetical protein; Provisional; Region: PRK00766 1173026005019 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173026005020 putative active site pocket [active] 1173026005021 dimerization interface [polypeptide binding]; other site 1173026005022 putative catalytic residue [active] 1173026005023 Putative zinc-finger; Region: zf-HC2; pfam13490 1173026005024 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1173026005025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026005026 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026005027 DNA binding residues [nucleotide binding] 1173026005028 Late competence development protein ComFB; Region: ComFB; pfam10719 1173026005029 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173026005030 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173026005031 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173026005032 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173026005033 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026005034 TrkA-N domain; Region: TrkA_N; pfam02254 1173026005035 TrkA-C domain; Region: TrkA_C; pfam02080 1173026005036 TrkA-C domain; Region: TrkA_C; pfam02080 1173026005037 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173026005038 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173026005039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026005040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026005041 Coenzyme A binding pocket [chemical binding]; other site 1173026005042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1173026005043 Sm and related proteins; Region: Sm_like; cl00259 1173026005044 heptamer interface [polypeptide binding]; other site 1173026005045 Sm1 motif; other site 1173026005046 hexamer interface [polypeptide binding]; other site 1173026005047 RNA binding site [nucleotide binding]; other site 1173026005048 Sm2 motif; other site 1173026005049 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173026005050 diaminopimelate epimerase; Region: PLN02536 1173026005051 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1173026005052 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173026005053 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 1173026005054 FO synthase subunit 2; Reviewed; Region: PRK07360 1173026005055 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026005056 FeS/SAM binding site; other site 1173026005057 Predicted membrane protein [Function unknown]; Region: COG5305 1173026005058 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1173026005059 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1173026005060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026005061 catalytic residue [active] 1173026005062 translation initiation factor Sui1; Validated; Region: PRK06824 1173026005063 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1173026005064 putative rRNA binding site [nucleotide binding]; other site 1173026005065 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1173026005066 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1173026005067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173026005068 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 1173026005069 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026005070 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026005071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026005072 S-adenosylmethionine binding site [chemical binding]; other site 1173026005073 homoserine kinase; Provisional; Region: PRK01212 1173026005074 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173026005075 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1173026005076 putative dimer interface [polypeptide binding]; other site 1173026005077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026005078 ligand binding site [chemical binding]; other site 1173026005079 Zn binding site [ion binding]; other site 1173026005080 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1173026005081 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1173026005082 DNA binding residues [nucleotide binding] 1173026005083 drug binding residues [chemical binding]; other site 1173026005084 dimer interface [polypeptide binding]; other site 1173026005085 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1173026005086 EamA-like transporter family; Region: EamA; pfam00892 1173026005087 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173026005088 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1173026005089 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1173026005090 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1173026005091 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1173026005092 DNA binding site [nucleotide binding] 1173026005093 active site 1173026005094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026005095 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1173026005096 DNA-binding site [nucleotide binding]; DNA binding site 1173026005097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026005098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026005099 homodimer interface [polypeptide binding]; other site 1173026005100 catalytic residue [active] 1173026005101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026005102 TPR motif; other site 1173026005103 binding surface 1173026005104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026005105 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026005106 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026005107 protein binding site [polypeptide binding]; other site 1173026005108 arogenate dehydrogenase; Reviewed; Region: PRK07417 1173026005109 prephenate dehydrogenase; Validated; Region: PRK08507 1173026005110 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 1173026005111 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1173026005112 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1173026005113 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 1173026005114 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173026005115 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1173026005116 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026005117 putative active site [active] 1173026005118 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1173026005119 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1173026005120 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173026005121 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026005122 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1173026005123 putative N-terminal domain interface [polypeptide binding]; other site 1173026005124 putative dimer interface [polypeptide binding]; other site 1173026005125 putative substrate binding pocket (H-site) [chemical binding]; other site 1173026005126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026005127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026005128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026005129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005130 AMIN domain; Region: AMIN; pfam11741 1173026005131 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005132 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005133 N-terminal plug; other site 1173026005134 ligand-binding site [chemical binding]; other site 1173026005135 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026005136 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026005137 siderophore binding site; other site 1173026005138 S-layer homology domain; Region: SLH; pfam00395 1173026005139 S-layer homology domain; Region: SLH; pfam00395 1173026005140 S-layer homology domain; Region: SLH; pfam00395 1173026005141 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173026005142 Predicted GTPase [General function prediction only]; Region: COG3596 1173026005143 YfjP GTPase; Region: YfjP; cd11383 1173026005144 G1 box; other site 1173026005145 GTP/Mg2+ binding site [chemical binding]; other site 1173026005146 Switch I region; other site 1173026005147 G2 box; other site 1173026005148 Switch II region; other site 1173026005149 G3 box; other site 1173026005150 G4 box; other site 1173026005151 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1173026005152 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026005153 putative active site [active] 1173026005154 threonine dehydratase; Reviewed; Region: PRK09224 1173026005155 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1173026005156 tetramer interface [polypeptide binding]; other site 1173026005157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026005158 catalytic residue [active] 1173026005159 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1173026005160 putative Ile/Val binding site [chemical binding]; other site 1173026005161 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1173026005162 putative Ile/Val binding site [chemical binding]; other site 1173026005163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026005164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026005165 active site 1173026005166 catalytic tetrad [active] 1173026005167 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1173026005168 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1173026005169 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 1173026005170 G1 box; other site 1173026005171 GTP/Mg2+ binding site [chemical binding]; other site 1173026005172 G2 box; other site 1173026005173 Switch I region; other site 1173026005174 G3 box; other site 1173026005175 Switch II region; other site 1173026005176 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173026005177 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1173026005178 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173026005179 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173026005180 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026005181 catalytic core [active] 1173026005182 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1173026005183 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1173026005184 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1173026005185 Catalytic site [active] 1173026005186 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 1173026005187 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026005188 ATP binding site [chemical binding]; other site 1173026005189 putative Mg++ binding site [ion binding]; other site 1173026005190 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026005191 nucleotide binding region [chemical binding]; other site 1173026005192 ATP-binding site [chemical binding]; other site 1173026005193 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1173026005194 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1173026005195 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1173026005196 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1173026005197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026005198 TPR repeat; Region: TPR_11; pfam13414 1173026005199 binding surface 1173026005200 TPR motif; other site 1173026005201 TPR repeat; Region: TPR_11; pfam13414 1173026005202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026005203 binding surface 1173026005204 TPR motif; other site 1173026005205 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026005206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026005207 TPR motif; other site 1173026005208 TPR repeat; Region: TPR_11; pfam13414 1173026005209 binding surface 1173026005210 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1173026005211 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1173026005212 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1173026005213 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173026005214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173026005215 Walker A/P-loop; other site 1173026005216 ATP binding site [chemical binding]; other site 1173026005217 Q-loop/lid; other site 1173026005218 ABC transporter signature motif; other site 1173026005219 Walker B; other site 1173026005220 D-loop; other site 1173026005221 H-loop/switch region; other site 1173026005222 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1173026005223 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1173026005224 PBP superfamily domain; Region: PBP_like_2; pfam12849 1173026005225 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668 1173026005226 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1173026005227 Aspartase; Region: Aspartase; cd01357 1173026005228 active sites [active] 1173026005229 tetramer interface [polypeptide binding]; other site 1173026005230 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1173026005231 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026005232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005233 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173026005234 putative active site [active] 1173026005235 AMIN domain; Region: AMIN; pfam11741 1173026005236 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005237 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005238 N-terminal plug; other site 1173026005239 ligand-binding site [chemical binding]; other site 1173026005240 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026005241 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026005242 siderophore binding site; other site 1173026005243 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1173026005244 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1173026005245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026005246 AMIN domain; Region: AMIN; pfam11741 1173026005247 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005248 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005249 N-terminal plug; other site 1173026005250 ligand-binding site [chemical binding]; other site 1173026005251 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1173026005252 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1173026005253 acyl-activating enzyme (AAE) consensus motif; other site 1173026005254 active site 1173026005255 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173026005256 Condensation domain; Region: Condensation; pfam00668 1173026005257 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005258 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005259 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005260 acyl-activating enzyme (AAE) consensus motif; other site 1173026005261 AMP binding site [chemical binding]; other site 1173026005262 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026005264 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1173026005265 active site 1173026005266 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173026005267 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173026005268 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173026005269 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173026005270 putative NADP binding site [chemical binding]; other site 1173026005271 active site 1173026005272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005273 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1173026005274 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1173026005275 Condensation domain; Region: Condensation; pfam00668 1173026005276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005277 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005278 Condensation domain; Region: Condensation; pfam00668 1173026005279 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005280 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173026005281 acyl-activating enzyme (AAE) consensus motif; other site 1173026005282 AMP binding site [chemical binding]; other site 1173026005283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005284 Condensation domain; Region: Condensation; pfam00668 1173026005285 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005286 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005287 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1173026005288 Condensation domain; Region: Condensation; pfam00668 1173026005289 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005290 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173026005291 acyl-activating enzyme (AAE) consensus motif; other site 1173026005292 AMP binding site [chemical binding]; other site 1173026005293 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005294 Condensation domain; Region: Condensation; pfam00668 1173026005295 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005296 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026005297 Condensation domain; Region: Condensation; pfam00668 1173026005298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005299 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005300 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005301 acyl-activating enzyme (AAE) consensus motif; other site 1173026005302 AMP binding site [chemical binding]; other site 1173026005303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005304 Condensation domain; Region: Condensation; pfam00668 1173026005305 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005306 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026005307 Condensation domain; Region: Condensation; pfam00668 1173026005308 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005309 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005310 acyl-activating enzyme (AAE) consensus motif; other site 1173026005311 AMP binding site [chemical binding]; other site 1173026005312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005313 Condensation domain; Region: Condensation; pfam00668 1173026005314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005316 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1173026005317 acyl-activating enzyme (AAE) consensus motif; other site 1173026005318 AMP binding site [chemical binding]; other site 1173026005319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005320 Condensation domain; Region: Condensation; pfam00668 1173026005321 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005322 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026005323 Condensation domain; Region: Condensation; pfam00668 1173026005324 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005326 Condensation domain; Region: Condensation; pfam00668 1173026005327 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005328 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005329 Condensation domain; Region: Condensation; pfam00668 1173026005330 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005331 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1173026005332 acyl-activating enzyme (AAE) consensus motif; other site 1173026005333 AMP binding site [chemical binding]; other site 1173026005334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005335 Condensation domain; Region: Condensation; pfam00668 1173026005336 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026005337 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026005338 Condensation domain; Region: Condensation; pfam00668 1173026005339 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 1173026005340 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026005341 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026005342 acyl-activating enzyme (AAE) consensus motif; other site 1173026005343 AMP binding site [chemical binding]; other site 1173026005344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026005345 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1173026005346 putative NAD(P) binding site [chemical binding]; other site 1173026005347 active site 1173026005348 putative substrate binding site [chemical binding]; other site 1173026005349 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1173026005350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1173026005351 inhibitor-cofactor binding pocket; inhibition site 1173026005352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026005353 catalytic residue [active] 1173026005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026005355 S-adenosylmethionine binding site [chemical binding]; other site 1173026005356 MbtH-like protein; Region: MbtH; cl01279 1173026005357 Penicillin amidase; Region: Penicil_amidase; pfam01804 1173026005358 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1173026005359 active site 1173026005360 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1173026005361 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1173026005362 DNA-binding interface [nucleotide binding]; DNA binding site 1173026005363 putative phosphoketolase; Provisional; Region: PRK05261 1173026005364 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1173026005365 TPP-binding site; other site 1173026005366 XFP C-terminal domain; Region: XFP_C; pfam09363 1173026005367 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1173026005368 CoA binding domain; Region: CoA_binding_2; pfam13380 1173026005369 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1173026005370 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1173026005371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026005372 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1173026005373 PIN domain; Region: PIN_3; pfam13470 1173026005374 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1173026005375 putative active site [active] 1173026005376 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1173026005377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005378 dimer interface [polypeptide binding]; other site 1173026005379 conserved gate region; other site 1173026005380 putative PBP binding loops; other site 1173026005381 ABC-ATPase subunit interface; other site 1173026005382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026005383 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1173026005384 Walker A/P-loop; other site 1173026005385 ATP binding site [chemical binding]; other site 1173026005386 Q-loop/lid; other site 1173026005387 ABC transporter signature motif; other site 1173026005388 Walker B; other site 1173026005389 D-loop; other site 1173026005390 H-loop/switch region; other site 1173026005391 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1173026005392 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026005393 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1173026005394 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026005395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026005396 S-adenosylmethionine binding site [chemical binding]; other site 1173026005397 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1173026005398 4Fe-4S binding domain; Region: Fer4; cl02805 1173026005399 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026005400 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026005401 catalytic loop [active] 1173026005402 iron binding site [ion binding]; other site 1173026005403 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173026005404 Rop-like; Region: Rop-like; pfam05082 1173026005405 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1173026005406 NifT/FixU protein; Region: NifT; pfam06988 1173026005407 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173026005408 dimer interface [polypeptide binding]; other site 1173026005409 [2Fe-2S] cluster binding site [ion binding]; other site 1173026005410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026005411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026005412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026005413 Walker A/P-loop; other site 1173026005414 ATP binding site [chemical binding]; other site 1173026005415 Q-loop/lid; other site 1173026005416 ABC transporter signature motif; other site 1173026005417 Walker B; other site 1173026005418 D-loop; other site 1173026005419 H-loop/switch region; other site 1173026005420 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 1173026005421 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1173026005422 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1173026005423 PhoH-like protein; Region: PhoH; pfam02562 1173026005424 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1173026005425 KH domain; Region: KH_4; pfam13083 1173026005426 ribosomal protein S16; Region: rps16; CHL00005 1173026005427 Protein of unknown function (DUF98); Region: DUF98; pfam01947 1173026005428 amidophosphoribosyltransferase; Provisional; Region: PRK07349 1173026005429 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1173026005430 active site 1173026005431 tetramer interface [polypeptide binding]; other site 1173026005432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026005433 active site 1173026005434 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1173026005435 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1173026005436 dimerization interface [polypeptide binding]; other site 1173026005437 ATP binding site [chemical binding]; other site 1173026005438 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1173026005439 dimerization interface [polypeptide binding]; other site 1173026005440 ATP binding site [chemical binding]; other site 1173026005441 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1173026005442 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1173026005443 dinuclear metal binding motif [ion binding]; other site 1173026005444 Staphylococcal nuclease homologues; Region: SNc; smart00318 1173026005445 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1173026005446 Catalytic site; other site 1173026005447 Isochorismatase family; Region: Isochorismatase; pfam00857 1173026005448 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173026005449 catalytic triad [active] 1173026005450 conserved cis-peptide bond; other site 1173026005451 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173026005452 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1173026005453 NADP binding site [chemical binding]; other site 1173026005454 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1173026005455 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1173026005456 NAD(P) binding site [chemical binding]; other site 1173026005457 catalytic residues [active] 1173026005458 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026005459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005461 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173026005462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173026005463 substrate binding pocket [chemical binding]; other site 1173026005464 membrane-bound complex binding site; other site 1173026005465 hinge residues; other site 1173026005466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1173026005467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005468 dimer interface [polypeptide binding]; other site 1173026005469 conserved gate region; other site 1173026005470 putative PBP binding loops; other site 1173026005471 ABC-ATPase subunit interface; other site 1173026005472 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173026005473 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173026005474 Walker A/P-loop; other site 1173026005475 ATP binding site [chemical binding]; other site 1173026005476 Q-loop/lid; other site 1173026005477 ABC transporter signature motif; other site 1173026005478 Walker B; other site 1173026005479 D-loop; other site 1173026005480 H-loop/switch region; other site 1173026005481 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 1173026005482 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1173026005483 30S subunit binding site; other site 1173026005484 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173026005485 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026005486 catalytic triad [active] 1173026005487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026005488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026005489 binding surface 1173026005490 TPR motif; other site 1173026005491 TPR repeat; Region: TPR_11; pfam13414 1173026005492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026005493 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173026005494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173026005495 ABC-ATPase subunit interface; other site 1173026005496 dimer interface [polypeptide binding]; other site 1173026005497 putative PBP binding regions; other site 1173026005498 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173026005499 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173026005500 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1173026005501 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1173026005502 metal binding site [ion binding]; metal-binding site 1173026005503 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 1173026005504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026005505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026005506 homodimer interface [polypeptide binding]; other site 1173026005507 catalytic residue [active] 1173026005508 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1173026005509 catalytic residues [active] 1173026005510 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173026005511 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1173026005512 Protein of unknown function (DUF721); Region: DUF721; cl02324 1173026005513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1173026005514 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1173026005515 substrate binding site [chemical binding]; other site 1173026005516 oxyanion hole (OAH) forming residues; other site 1173026005517 trimer interface [polypeptide binding]; other site 1173026005518 PIN domain; Region: PIN_3; cl17397 1173026005519 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1173026005520 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1173026005521 dimer interface [polypeptide binding]; other site 1173026005522 tetramer interface [polypeptide binding]; other site 1173026005523 PYR/PP interface [polypeptide binding]; other site 1173026005524 TPP binding site [chemical binding]; other site 1173026005525 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1173026005526 TPP-binding site; other site 1173026005527 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1173026005528 homooctamer interface [polypeptide binding]; other site 1173026005529 active site 1173026005530 Trehalase; Region: Trehalase; cl17346 1173026005531 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1173026005532 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173026005533 Walker A/P-loop; other site 1173026005534 ATP binding site [chemical binding]; other site 1173026005535 Q-loop/lid; other site 1173026005536 ABC transporter signature motif; other site 1173026005537 Walker B; other site 1173026005538 D-loop; other site 1173026005539 H-loop/switch region; other site 1173026005540 TOBE domain; Region: TOBE_2; pfam08402 1173026005541 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173026005542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005543 dimer interface [polypeptide binding]; other site 1173026005544 conserved gate region; other site 1173026005545 putative PBP binding loops; other site 1173026005546 ABC-ATPase subunit interface; other site 1173026005547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005548 dimer interface [polypeptide binding]; other site 1173026005549 conserved gate region; other site 1173026005550 putative PBP binding loops; other site 1173026005551 ABC-ATPase subunit interface; other site 1173026005552 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173026005553 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173026005554 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1173026005555 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173026005556 active site 1173026005557 ATP binding site [chemical binding]; other site 1173026005558 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1173026005559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173026005560 substrate binding pocket [chemical binding]; other site 1173026005561 membrane-bound complex binding site; other site 1173026005562 hinge residues; other site 1173026005563 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1173026005564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005565 conserved gate region; other site 1173026005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005567 ABC-ATPase subunit interface; other site 1173026005568 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1173026005569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005570 dimer interface [polypeptide binding]; other site 1173026005571 conserved gate region; other site 1173026005572 ABC-ATPase subunit interface; other site 1173026005573 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173026005574 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173026005575 Walker A/P-loop; other site 1173026005576 ATP binding site [chemical binding]; other site 1173026005577 Q-loop/lid; other site 1173026005578 ABC transporter signature motif; other site 1173026005579 Walker B; other site 1173026005580 D-loop; other site 1173026005581 H-loop/switch region; other site 1173026005582 signal recognition particle protein; Provisional; Region: PRK10867 1173026005583 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1173026005584 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1173026005585 GTP binding site [chemical binding]; other site 1173026005586 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1173026005587 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1173026005588 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173026005589 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173026005590 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1173026005591 YGGT family; Region: YGGT; pfam02325 1173026005592 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 1173026005593 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 1173026005594 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1173026005595 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173026005596 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173026005597 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1173026005598 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 1173026005599 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173026005600 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1173026005601 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 1173026005602 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026005603 catalytic loop [active] 1173026005604 iron binding site [ion binding]; other site 1173026005605 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 1173026005606 CAAX protease self-immunity; Region: Abi; pfam02517 1173026005607 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1173026005608 active site 1173026005609 putative homodimer interface [polypeptide binding]; other site 1173026005610 SAM binding site [chemical binding]; other site 1173026005611 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1173026005612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026005613 S-adenosylmethionine binding site [chemical binding]; other site 1173026005614 precorrin-8X methylmutase; Provisional; Region: PRK05954 1173026005615 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1173026005616 DNA polymerase III subunit delta; Validated; Region: PRK07452 1173026005617 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1173026005618 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 1173026005619 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1173026005620 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1173026005621 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026005622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026005623 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1173026005624 Walker A/P-loop; other site 1173026005625 ATP binding site [chemical binding]; other site 1173026005626 Q-loop/lid; other site 1173026005627 ABC transporter signature motif; other site 1173026005628 Walker B; other site 1173026005629 D-loop; other site 1173026005630 H-loop/switch region; other site 1173026005631 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1173026005632 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026005633 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173026005634 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1173026005635 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1173026005636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026005637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026005638 active site 1173026005639 phosphorylation site [posttranslational modification] 1173026005640 intermolecular recognition site; other site 1173026005641 dimerization interface [polypeptide binding]; other site 1173026005642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026005643 DNA binding site [nucleotide binding] 1173026005644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026005645 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173026005646 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1173026005647 putative acyl-acceptor binding pocket; other site 1173026005648 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1173026005649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173026005650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026005651 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026005652 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1173026005653 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173026005654 active site 1173026005655 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1173026005656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026005657 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1173026005658 arsenical-resistance protein; Region: acr3; TIGR00832 1173026005659 PBP superfamily domain; Region: PBP_like_2; cl17296 1173026005660 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026005661 dimerization interface [polypeptide binding]; other site 1173026005662 putative DNA binding site [nucleotide binding]; other site 1173026005663 putative Zn2+ binding site [ion binding]; other site 1173026005664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026005665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026005666 Coenzyme A binding pocket [chemical binding]; other site 1173026005667 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173026005668 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173026005669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026005670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005671 AMIN domain; Region: AMIN; pfam11741 1173026005672 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005673 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005674 N-terminal plug; other site 1173026005675 ligand-binding site [chemical binding]; other site 1173026005676 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173026005677 AMIN domain; Region: AMIN; pfam11741 1173026005678 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005679 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005680 N-terminal plug; other site 1173026005681 ligand-binding site [chemical binding]; other site 1173026005682 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026005683 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026005684 siderophore binding site; other site 1173026005685 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173026005686 active site 1173026005687 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1173026005688 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 1173026005689 active site 1173026005690 catalytic triad [active] 1173026005691 oxyanion hole [active] 1173026005692 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1173026005693 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 1173026005694 putative ligand binding site [chemical binding]; other site 1173026005695 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1173026005696 active site lid residues [active] 1173026005697 substrate binding pocket [chemical binding]; other site 1173026005698 catalytic residues [active] 1173026005699 substrate-Mg2+ binding site; other site 1173026005700 aspartate-rich region 1; other site 1173026005701 aspartate-rich region 2; other site 1173026005702 phytoene desaturase; Region: phytoene_desat; TIGR02731 1173026005703 phytoene desaturase; Region: phytoene_desat; TIGR02731 1173026005704 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1173026005705 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173026005706 molecular chaperone DnaK; Provisional; Region: PRK13410 1173026005707 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1173026005708 nucleotide binding site [chemical binding]; other site 1173026005709 NEF interaction site [polypeptide binding]; other site 1173026005710 SBD interface [polypeptide binding]; other site 1173026005711 chaperone protein DnaJ; Provisional; Region: PRK14299 1173026005712 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026005713 HSP70 interaction site [polypeptide binding]; other site 1173026005714 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173026005715 dimer interface [polypeptide binding]; other site 1173026005716 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173026005717 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1173026005718 urea carboxylase; Region: urea_carbox; TIGR02712 1173026005719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173026005720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026005721 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1173026005722 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1173026005723 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1173026005724 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173026005725 carboxyltransferase (CT) interaction site; other site 1173026005726 biotinylation site [posttranslational modification]; other site 1173026005727 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1173026005728 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1173026005729 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1173026005730 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1173026005731 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1173026005732 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1173026005733 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1173026005734 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1173026005735 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1173026005736 trimerization site [polypeptide binding]; other site 1173026005737 active site 1173026005738 Protein of function (DUF2518); Region: DUF2518; pfam10726 1173026005739 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1173026005740 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1173026005741 putative active site [active] 1173026005742 metal binding site [ion binding]; metal-binding site 1173026005743 aspartate aminotransferase; Provisional; Region: PRK05942 1173026005744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026005745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026005746 homodimer interface [polypeptide binding]; other site 1173026005747 catalytic residue [active] 1173026005748 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173026005749 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1173026005750 NlpC/P60 family; Region: NLPC_P60; pfam00877 1173026005751 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1173026005752 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173026005753 Ligand binding site; other site 1173026005754 Putative Catalytic site; other site 1173026005755 DXD motif; other site 1173026005756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026005757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026005758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026005759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026005760 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1173026005761 trimer interface [polypeptide binding]; other site 1173026005762 dimer interface [polypeptide binding]; other site 1173026005763 putative active site [active] 1173026005764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026005765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026005766 active site 1173026005767 catalytic tetrad [active] 1173026005768 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026005769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005770 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026005771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026005773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026005774 DNA binding residues [nucleotide binding] 1173026005775 dimerization interface [polypeptide binding]; other site 1173026005776 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026005777 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026005778 protein binding site [polypeptide binding]; other site 1173026005779 2TM domain; Region: 2TM; pfam13239 1173026005780 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 1173026005781 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1173026005782 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1173026005783 YcfA-like protein; Region: YcfA; pfam07927 1173026005784 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173026005785 LysE type translocator; Region: LysE; pfam01810 1173026005786 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1173026005787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026005788 Walker A/P-loop; other site 1173026005789 ATP binding site [chemical binding]; other site 1173026005790 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 1173026005791 DNA-sulfur modification-associated; Region: DndB; pfam14072 1173026005792 DGQHR domain; Region: DGQHR; TIGR03187 1173026005793 DNA-sulfur modification-associated; Region: DndB; cl17621 1173026005794 hypothetical protein; Provisional; Region: PRK06850 1173026005795 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173026005796 Active Sites [active] 1173026005797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1173026005798 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1173026005799 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 1173026005800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026005801 Walker A/P-loop; other site 1173026005802 ATP binding site [chemical binding]; other site 1173026005803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026005804 ABC transporter signature motif; other site 1173026005805 Walker B; other site 1173026005806 D-loop; other site 1173026005807 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 1173026005808 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 1173026005809 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026005810 putative active site [active] 1173026005811 muropeptide transporter; Validated; Region: ampG; cl17669 1173026005812 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1173026005813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026005814 Coenzyme A binding pocket [chemical binding]; other site 1173026005815 HEAT repeats; Region: HEAT_2; pfam13646 1173026005816 HEAT repeats; Region: HEAT_2; pfam13646 1173026005817 HEAT repeats; Region: HEAT_2; pfam13646 1173026005818 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 1173026005819 Predicted membrane protein [Function unknown]; Region: COG3431 1173026005820 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173026005821 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1173026005822 Cl- selectivity filter; other site 1173026005823 Cl- binding residues [ion binding]; other site 1173026005824 pore gating glutamate residue; other site 1173026005825 dimer interface [polypeptide binding]; other site 1173026005826 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1173026005827 dimer interface [polypeptide binding]; other site 1173026005828 substrate binding site [chemical binding]; other site 1173026005829 metal binding sites [ion binding]; metal-binding site 1173026005830 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1173026005831 tetramerization interface [polypeptide binding]; other site 1173026005832 active site 1173026005833 FeoA domain; Region: FeoA; pfam04023 1173026005834 FeoA domain; Region: FeoA; pfam04023 1173026005835 hypothetical protein; Provisional; Region: PRK07394 1173026005836 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1173026005837 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1173026005838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173026005839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026005840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173026005841 dimerization interface [polypeptide binding]; other site 1173026005842 HEAT repeats; Region: HEAT_2; pfam13646 1173026005843 HEAT repeats; Region: HEAT_2; pfam13646 1173026005844 HEAT repeats; Region: HEAT_2; pfam13646 1173026005845 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1173026005846 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173026005847 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173026005848 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173026005849 NMT1-like family; Region: NMT1_2; pfam13379 1173026005850 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026005851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026005852 putative PBP binding loops; other site 1173026005853 dimer interface [polypeptide binding]; other site 1173026005854 ABC-ATPase subunit interface; other site 1173026005855 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026005856 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173026005857 Walker A/P-loop; other site 1173026005858 ATP binding site [chemical binding]; other site 1173026005859 Q-loop/lid; other site 1173026005860 ABC transporter signature motif; other site 1173026005861 Walker B; other site 1173026005862 D-loop; other site 1173026005863 H-loop/switch region; other site 1173026005864 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173026005865 NMT1-like family; Region: NMT1_2; pfam13379 1173026005866 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026005867 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173026005868 Walker A/P-loop; other site 1173026005869 ATP binding site [chemical binding]; other site 1173026005870 Q-loop/lid; other site 1173026005871 ABC transporter signature motif; other site 1173026005872 Walker B; other site 1173026005873 D-loop; other site 1173026005874 H-loop/switch region; other site 1173026005875 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1173026005876 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1173026005877 [4Fe-4S] binding site [ion binding]; other site 1173026005878 molybdopterin cofactor binding site; other site 1173026005879 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1173026005880 molybdopterin cofactor binding site; other site 1173026005881 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1173026005882 TrkA-N domain; Region: TrkA_N; pfam02254 1173026005883 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026005884 TrkA-N domain; Region: TrkA_N; pfam02254 1173026005885 TrkA-C domain; Region: TrkA_C; pfam02080 1173026005886 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1173026005887 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1173026005888 active site 1173026005889 purine riboside binding site [chemical binding]; other site 1173026005890 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1173026005891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026005892 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1173026005893 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026005894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026005895 S-adenosylmethionine binding site [chemical binding]; other site 1173026005896 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026005897 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026005898 siderophore binding site; other site 1173026005899 AMIN domain; Region: AMIN; pfam11741 1173026005900 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026005901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026005902 N-terminal plug; other site 1173026005903 ligand-binding site [chemical binding]; other site 1173026005904 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026005905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026005906 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1173026005907 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1173026005908 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026005909 ATP binding site [chemical binding]; other site 1173026005910 putative Mg++ binding site [ion binding]; other site 1173026005911 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026005912 nucleotide binding region [chemical binding]; other site 1173026005913 ATP-binding site [chemical binding]; other site 1173026005914 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1173026005915 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173026005916 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173026005917 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173026005918 Transporter associated domain; Region: CorC_HlyC; smart01091 1173026005919 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1173026005920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026005921 NAD(P) binding site [chemical binding]; other site 1173026005922 active site 1173026005923 ferredoxin-sulfite reductase; Region: sir; TIGR02042 1173026005924 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173026005925 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1173026005926 RNA methyltransferase, RsmE family; Region: TIGR00046 1173026005927 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 1173026005928 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1173026005929 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026005930 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026005931 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173026005932 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173026005933 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1173026005934 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1173026005935 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 1173026005936 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1173026005937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173026005938 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1173026005939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173026005940 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1173026005941 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1173026005942 putative active site [active] 1173026005943 putative dimer interface [polypeptide binding]; other site 1173026005944 phytoene desaturase; Region: crtI_fam; TIGR02734 1173026005945 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026005946 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173026005947 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173026005948 putative active site [active] 1173026005949 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 1173026005950 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1173026005951 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173026005952 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1173026005953 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173026005954 metal binding site 2 [ion binding]; metal-binding site 1173026005955 putative DNA binding helix; other site 1173026005956 metal binding site 1 [ion binding]; metal-binding site 1173026005957 dimer interface [polypeptide binding]; other site 1173026005958 structural Zn2+ binding site [ion binding]; other site 1173026005959 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1173026005960 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1173026005961 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1173026005962 putative active site [active] 1173026005963 catalytic triad [active] 1173026005964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026005965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1173026005966 active site 1173026005967 metal binding site [ion binding]; metal-binding site 1173026005968 Integral membrane protein DUF92; Region: DUF92; pfam01940 1173026005969 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173026005970 DNA binding domain, excisionase family; Region: excise; TIGR01764 1173026005971 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173026005972 Probable transposase; Region: OrfB_IS605; pfam01385 1173026005973 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1173026005974 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173026005975 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 1173026005976 putative NAD(P) binding site [chemical binding]; other site 1173026005977 catalytic Zn binding site [ion binding]; other site 1173026005978 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1173026005979 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026005980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026005981 active site 1173026005982 phosphorylation site [posttranslational modification] 1173026005983 intermolecular recognition site; other site 1173026005984 dimerization interface [polypeptide binding]; other site 1173026005985 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1173026005986 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026005987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026005988 active site 1173026005989 phosphorylation site [posttranslational modification] 1173026005990 intermolecular recognition site; other site 1173026005991 dimerization interface [polypeptide binding]; other site 1173026005992 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1173026005993 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1173026005994 NAD(P) binding site [chemical binding]; other site 1173026005995 catalytic residues [active] 1173026005996 acetolactate synthase; Reviewed; Region: PRK08322 1173026005997 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173026005998 PYR/PP interface [polypeptide binding]; other site 1173026005999 dimer interface [polypeptide binding]; other site 1173026006000 TPP binding site [chemical binding]; other site 1173026006001 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173026006002 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1173026006003 TPP-binding site [chemical binding]; other site 1173026006004 dimer interface [polypeptide binding]; other site 1173026006005 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1173026006006 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1173026006007 putative catalytic site [active] 1173026006008 putative phosphate binding site [ion binding]; other site 1173026006009 active site 1173026006010 metal binding site A [ion binding]; metal-binding site 1173026006011 DNA binding site [nucleotide binding] 1173026006012 putative AP binding site [nucleotide binding]; other site 1173026006013 putative metal binding site B [ion binding]; other site 1173026006014 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173026006015 Ycf39; Provisional; Region: ycf39; CHL00194 1173026006016 NAD(P) binding site [chemical binding]; other site 1173026006017 putative active site [active] 1173026006018 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1173026006019 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1173026006020 GTP binding site; other site 1173026006021 CHASE4 domain; Region: CHASE4; pfam05228 1173026006022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006023 PAS domain; Region: PAS_9; pfam13426 1173026006024 putative active site [active] 1173026006025 heme pocket [chemical binding]; other site 1173026006026 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026006027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026006028 metal binding site [ion binding]; metal-binding site 1173026006029 active site 1173026006030 I-site; other site 1173026006031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026006032 CsbD-like; Region: CsbD; cl17424 1173026006033 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1173026006034 MOSC domain; Region: MOSC; pfam03473 1173026006035 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026006036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006037 putative active site [active] 1173026006038 heme pocket [chemical binding]; other site 1173026006039 PAS fold; Region: PAS_4; pfam08448 1173026006040 PAS fold; Region: PAS_4; pfam08448 1173026006041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006042 putative active site [active] 1173026006043 heme pocket [chemical binding]; other site 1173026006044 PAS fold; Region: PAS_4; pfam08448 1173026006045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006046 putative active site [active] 1173026006047 heme pocket [chemical binding]; other site 1173026006048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006049 PAS fold; Region: PAS_3; pfam08447 1173026006050 putative active site [active] 1173026006051 heme pocket [chemical binding]; other site 1173026006052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006053 PAS fold; Region: PAS_3; pfam08447 1173026006054 putative active site [active] 1173026006055 heme pocket [chemical binding]; other site 1173026006056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006058 dimer interface [polypeptide binding]; other site 1173026006059 phosphorylation site [posttranslational modification] 1173026006060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006061 ATP binding site [chemical binding]; other site 1173026006062 Mg2+ binding site [ion binding]; other site 1173026006063 G-X-G motif; other site 1173026006064 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006066 active site 1173026006067 phosphorylation site [posttranslational modification] 1173026006068 intermolecular recognition site; other site 1173026006069 dimerization interface [polypeptide binding]; other site 1173026006070 Tic20-like protein; Region: Tic20; pfam09685 1173026006071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026006072 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1173026006073 NAD(P) binding site [chemical binding]; other site 1173026006074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026006075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1173026006076 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1173026006077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026006078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026006079 homodimer interface [polypeptide binding]; other site 1173026006080 catalytic residue [active] 1173026006081 Transposase IS200 like; Region: Y1_Tnp; cl00848 1173026006082 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1173026006083 homodimer interface [polypeptide binding]; other site 1173026006084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026006085 catalytic residue [active] 1173026006086 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1173026006087 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1173026006088 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1173026006089 putative dimer interface [polypeptide binding]; other site 1173026006090 N-terminal domain interface [polypeptide binding]; other site 1173026006091 putative substrate binding pocket (H-site) [chemical binding]; other site 1173026006092 S-formylglutathione hydrolase; Region: PLN02442 1173026006093 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1173026006094 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173026006095 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173026006096 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1173026006097 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1173026006098 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1173026006099 substrate binding site [chemical binding]; other site 1173026006100 catalytic Zn binding site [ion binding]; other site 1173026006101 NAD binding site [chemical binding]; other site 1173026006102 structural Zn binding site [ion binding]; other site 1173026006103 dimer interface [polypeptide binding]; other site 1173026006104 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173026006105 classical (c) SDRs; Region: SDR_c; cd05233 1173026006106 NAD(P) binding site [chemical binding]; other site 1173026006107 active site 1173026006108 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1173026006109 23S rRNA binding site [nucleotide binding]; other site 1173026006110 L21 binding site [polypeptide binding]; other site 1173026006111 L13 binding site [polypeptide binding]; other site 1173026006112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173026006113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173026006114 substrate binding pocket [chemical binding]; other site 1173026006115 membrane-bound complex binding site; other site 1173026006116 hinge residues; other site 1173026006117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026006118 binding surface 1173026006119 TPR motif; other site 1173026006120 TPR repeat; Region: TPR_11; pfam13414 1173026006121 Photosystem II protein Y (PsbY); Region: PsbY; pfam06298 1173026006122 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173026006123 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1173026006124 trimer interface [polypeptide binding]; other site 1173026006125 putative metal binding site [ion binding]; other site 1173026006126 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 1173026006127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026006128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173026006129 active site 1173026006130 metal binding site [ion binding]; metal-binding site 1173026006131 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 1173026006132 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1173026006133 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173026006134 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1173026006135 photosystem II 47 kDa protein; Region: psbB; CHL00062 1173026006136 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 1173026006137 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1173026006138 ATP cone domain; Region: ATP-cone; pfam03477 1173026006139 30S ribosomal protein S1; Reviewed; Region: PRK07400 1173026006140 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1173026006141 RNA binding site [nucleotide binding]; other site 1173026006142 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1173026006143 RNA binding site [nucleotide binding]; other site 1173026006144 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1173026006145 RNA binding site [nucleotide binding]; other site 1173026006146 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173026006147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026006148 motif II; other site 1173026006149 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1173026006150 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1173026006151 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1173026006152 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1173026006153 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1173026006154 carotene isomerase; Region: carot_isom; TIGR02730 1173026006155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026006156 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1173026006157 tellurium resistance terB-like protein; Region: terB_like; cl11965 1173026006158 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026006159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026006160 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026006161 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 1173026006162 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173026006163 AMIN domain; Region: AMIN; pfam11741 1173026006164 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026006165 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026006166 N-terminal plug; other site 1173026006167 ligand-binding site [chemical binding]; other site 1173026006168 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026006169 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026006170 siderophore binding site; other site 1173026006171 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173026006172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173026006173 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173026006174 Probable transposase; Region: OrfB_IS605; pfam01385 1173026006175 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173026006176 CHASE3 domain; Region: CHASE3; pfam05227 1173026006177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006178 PAS fold; Region: PAS_3; pfam08447 1173026006179 putative active site [active] 1173026006180 heme pocket [chemical binding]; other site 1173026006181 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006182 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006184 PAS fold; Region: PAS_4; pfam08448 1173026006185 putative active site [active] 1173026006186 heme pocket [chemical binding]; other site 1173026006187 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006189 putative active site [active] 1173026006190 heme pocket [chemical binding]; other site 1173026006191 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006192 GAF domain; Region: GAF; pfam01590 1173026006193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006194 PAS fold; Region: PAS_3; pfam08447 1173026006195 putative active site [active] 1173026006196 heme pocket [chemical binding]; other site 1173026006197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006198 dimer interface [polypeptide binding]; other site 1173026006199 phosphorylation site [posttranslational modification] 1173026006200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006201 ATP binding site [chemical binding]; other site 1173026006202 Mg2+ binding site [ion binding]; other site 1173026006203 G-X-G motif; other site 1173026006204 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006206 active site 1173026006207 phosphorylation site [posttranslational modification] 1173026006208 intermolecular recognition site; other site 1173026006209 dimerization interface [polypeptide binding]; other site 1173026006210 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006212 dimer interface [polypeptide binding]; other site 1173026006213 phosphorylation site [posttranslational modification] 1173026006214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006215 ATP binding site [chemical binding]; other site 1173026006216 Mg2+ binding site [ion binding]; other site 1173026006217 G-X-G motif; other site 1173026006218 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173026006219 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1173026006220 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006222 active site 1173026006223 phosphorylation site [posttranslational modification] 1173026006224 intermolecular recognition site; other site 1173026006225 dimerization interface [polypeptide binding]; other site 1173026006226 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006228 active site 1173026006229 phosphorylation site [posttranslational modification] 1173026006230 intermolecular recognition site; other site 1173026006231 dimerization interface [polypeptide binding]; other site 1173026006232 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006234 putative active site [active] 1173026006235 heme pocket [chemical binding]; other site 1173026006236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006237 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006239 dimer interface [polypeptide binding]; other site 1173026006240 phosphorylation site [posttranslational modification] 1173026006241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006242 ATP binding site [chemical binding]; other site 1173026006243 Mg2+ binding site [ion binding]; other site 1173026006244 G-X-G motif; other site 1173026006245 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006247 active site 1173026006248 phosphorylation site [posttranslational modification] 1173026006249 intermolecular recognition site; other site 1173026006250 dimerization interface [polypeptide binding]; other site 1173026006251 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006253 active site 1173026006254 phosphorylation site [posttranslational modification] 1173026006255 intermolecular recognition site; other site 1173026006256 dimerization interface [polypeptide binding]; other site 1173026006257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026006258 non-specific DNA binding site [nucleotide binding]; other site 1173026006259 salt bridge; other site 1173026006260 sequence-specific DNA binding site [nucleotide binding]; other site 1173026006261 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006262 PAS domain; Region: PAS_9; pfam13426 1173026006263 putative active site [active] 1173026006264 heme pocket [chemical binding]; other site 1173026006265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006266 PAS fold; Region: PAS_3; pfam08447 1173026006267 putative active site [active] 1173026006268 heme pocket [chemical binding]; other site 1173026006269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006270 PAS fold; Region: PAS_4; pfam08448 1173026006271 putative active site [active] 1173026006272 heme pocket [chemical binding]; other site 1173026006273 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006275 putative active site [active] 1173026006276 heme pocket [chemical binding]; other site 1173026006277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006278 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026006279 putative active site [active] 1173026006280 heme pocket [chemical binding]; other site 1173026006281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006282 putative active site [active] 1173026006283 heme pocket [chemical binding]; other site 1173026006284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006285 PAS fold; Region: PAS_4; pfam08448 1173026006286 putative active site [active] 1173026006287 heme pocket [chemical binding]; other site 1173026006288 PAS domain; Region: PAS_9; pfam13426 1173026006289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006290 putative active site [active] 1173026006291 heme pocket [chemical binding]; other site 1173026006292 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006293 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006294 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026006295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006296 putative active site [active] 1173026006297 heme pocket [chemical binding]; other site 1173026006298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006299 dimer interface [polypeptide binding]; other site 1173026006300 phosphorylation site [posttranslational modification] 1173026006301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006302 ATP binding site [chemical binding]; other site 1173026006303 Mg2+ binding site [ion binding]; other site 1173026006304 G-X-G motif; other site 1173026006305 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006307 active site 1173026006308 phosphorylation site [posttranslational modification] 1173026006309 intermolecular recognition site; other site 1173026006310 dimerization interface [polypeptide binding]; other site 1173026006311 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173026006312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006313 PAS fold; Region: PAS_3; pfam08447 1173026006314 putative active site [active] 1173026006315 heme pocket [chemical binding]; other site 1173026006316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006317 GAF domain; Region: GAF; pfam01590 1173026006318 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006320 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026006321 putative active site [active] 1173026006322 heme pocket [chemical binding]; other site 1173026006323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006324 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026006325 putative active site [active] 1173026006326 heme pocket [chemical binding]; other site 1173026006327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006328 putative active site [active] 1173026006329 heme pocket [chemical binding]; other site 1173026006330 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006331 GAF domain; Region: GAF; pfam01590 1173026006332 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026006333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006334 putative active site [active] 1173026006335 heme pocket [chemical binding]; other site 1173026006336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006337 putative active site [active] 1173026006338 heme pocket [chemical binding]; other site 1173026006339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006341 dimer interface [polypeptide binding]; other site 1173026006342 phosphorylation site [posttranslational modification] 1173026006343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006344 ATP binding site [chemical binding]; other site 1173026006345 Mg2+ binding site [ion binding]; other site 1173026006346 G-X-G motif; other site 1173026006347 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006349 active site 1173026006350 phosphorylation site [posttranslational modification] 1173026006351 intermolecular recognition site; other site 1173026006352 dimerization interface [polypeptide binding]; other site 1173026006353 GAF domain; Region: GAF_3; pfam13492 1173026006354 GAF domain; Region: GAF_2; pfam13185 1173026006355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006357 dimer interface [polypeptide binding]; other site 1173026006358 phosphorylation site [posttranslational modification] 1173026006359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006360 ATP binding site [chemical binding]; other site 1173026006361 Mg2+ binding site [ion binding]; other site 1173026006362 G-X-G motif; other site 1173026006363 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006365 active site 1173026006366 phosphorylation site [posttranslational modification] 1173026006367 intermolecular recognition site; other site 1173026006368 dimerization interface [polypeptide binding]; other site 1173026006369 PAS fold; Region: PAS_4; pfam08448 1173026006370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006371 putative active site [active] 1173026006372 heme pocket [chemical binding]; other site 1173026006373 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006374 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006376 PAS fold; Region: PAS_3; pfam08447 1173026006377 putative active site [active] 1173026006378 heme pocket [chemical binding]; other site 1173026006379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006381 dimer interface [polypeptide binding]; other site 1173026006382 phosphorylation site [posttranslational modification] 1173026006383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006384 ATP binding site [chemical binding]; other site 1173026006385 Mg2+ binding site [ion binding]; other site 1173026006386 G-X-G motif; other site 1173026006387 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006389 active site 1173026006390 phosphorylation site [posttranslational modification] 1173026006391 intermolecular recognition site; other site 1173026006392 dimerization interface [polypeptide binding]; other site 1173026006393 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006394 GAF domain; Region: GAF; pfam01590 1173026006395 PAS fold; Region: PAS_3; pfam08447 1173026006396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006397 heme pocket [chemical binding]; other site 1173026006398 putative active site [active] 1173026006399 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026006400 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006401 putative active site [active] 1173026006402 heme pocket [chemical binding]; other site 1173026006403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006404 dimer interface [polypeptide binding]; other site 1173026006405 phosphorylation site [posttranslational modification] 1173026006406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006407 ATP binding site [chemical binding]; other site 1173026006408 Mg2+ binding site [ion binding]; other site 1173026006409 G-X-G motif; other site 1173026006410 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006412 active site 1173026006413 phosphorylation site [posttranslational modification] 1173026006414 intermolecular recognition site; other site 1173026006415 dimerization interface [polypeptide binding]; other site 1173026006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006417 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006418 active site 1173026006419 phosphorylation site [posttranslational modification] 1173026006420 intermolecular recognition site; other site 1173026006421 dimerization interface [polypeptide binding]; other site 1173026006422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006423 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026006424 putative active site [active] 1173026006425 heme pocket [chemical binding]; other site 1173026006426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006427 putative active site [active] 1173026006428 heme pocket [chemical binding]; other site 1173026006429 GAF domain; Region: GAF; pfam01590 1173026006430 GAF domain; Region: GAF_2; pfam13185 1173026006431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006433 dimer interface [polypeptide binding]; other site 1173026006434 phosphorylation site [posttranslational modification] 1173026006435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006436 ATP binding site [chemical binding]; other site 1173026006437 Mg2+ binding site [ion binding]; other site 1173026006438 G-X-G motif; other site 1173026006439 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026006440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006441 active site 1173026006442 phosphorylation site [posttranslational modification] 1173026006443 intermolecular recognition site; other site 1173026006444 dimerization interface [polypeptide binding]; other site 1173026006445 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1173026006446 Beta-lactamase; Region: Beta-lactamase; pfam00144 1173026006447 Transient receptor potential (TRP) ion channel; Region: TRP; pfam06011 1173026006448 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 1173026006449 TIGR02588 family protein; Region: TIGR02588 1173026006450 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026006451 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026006452 Amidohydrolase; Region: Amidohydro_2; pfam04909 1173026006453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026006454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006455 active site 1173026006456 phosphorylation site [posttranslational modification] 1173026006457 intermolecular recognition site; other site 1173026006458 dimerization interface [polypeptide binding]; other site 1173026006459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026006460 DNA binding site [nucleotide binding] 1173026006461 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026006462 putative binding surface; other site 1173026006463 active site 1173026006464 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173026006465 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026006466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006467 putative active site [active] 1173026006468 heme pocket [chemical binding]; other site 1173026006469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006470 dimer interface [polypeptide binding]; other site 1173026006471 phosphorylation site [posttranslational modification] 1173026006472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006473 ATP binding site [chemical binding]; other site 1173026006474 Mg2+ binding site [ion binding]; other site 1173026006475 G-X-G motif; other site 1173026006476 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006478 active site 1173026006479 phosphorylation site [posttranslational modification] 1173026006480 intermolecular recognition site; other site 1173026006481 dimerization interface [polypeptide binding]; other site 1173026006482 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026006483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006484 active site 1173026006485 phosphorylation site [posttranslational modification] 1173026006486 intermolecular recognition site; other site 1173026006487 dimerization interface [polypeptide binding]; other site 1173026006488 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173026006489 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026006490 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026006491 protein binding site [polypeptide binding]; other site 1173026006492 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173026006493 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173026006494 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173026006495 Family of unknown function (DUF490); Region: DUF490; pfam04357 1173026006496 Bacterial SH3 domain; Region: SH3_3; cl17532 1173026006497 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173026006498 dimerization interface [polypeptide binding]; other site 1173026006499 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1173026006500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026006501 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026006502 Domain of unknown function (DUF305); Region: DUF305; cl17794 1173026006503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173026006504 classical (c) SDRs; Region: SDR_c; cd05233 1173026006505 NAD(P) binding site [chemical binding]; other site 1173026006506 active site 1173026006507 PRC-barrel domain; Region: PRC; pfam05239 1173026006508 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1173026006509 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1173026006510 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1173026006511 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1173026006512 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173026006513 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173026006514 Predicted membrane protein [Function unknown]; Region: COG4325 1173026006515 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1173026006516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026006517 non-specific DNA binding site [nucleotide binding]; other site 1173026006518 salt bridge; other site 1173026006519 sequence-specific DNA binding site [nucleotide binding]; other site 1173026006520 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1173026006521 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1173026006522 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1173026006523 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 1173026006524 acylphosphatase; Provisional; Region: PRK14423 1173026006525 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1173026006526 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1173026006527 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 1173026006528 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1173026006529 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1173026006530 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1173026006531 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1173026006532 putative NAD(P) binding site [chemical binding]; other site 1173026006533 putative substrate binding site [chemical binding]; other site 1173026006534 catalytic Zn binding site [ion binding]; other site 1173026006535 structural Zn binding site [ion binding]; other site 1173026006536 aspartate aminotransferase; Provisional; Region: PRK05764 1173026006537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026006538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026006539 homodimer interface [polypeptide binding]; other site 1173026006540 catalytic residue [active] 1173026006541 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1173026006542 active site 1173026006543 catalytic triad [active] 1173026006544 oxyanion hole [active] 1173026006545 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1173026006546 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1173026006547 putative active site; other site 1173026006548 catalytic residue [active] 1173026006549 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026006550 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026006551 active site 1173026006552 catalytic tetrad [active] 1173026006553 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026006554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026006555 S-adenosylmethionine binding site [chemical binding]; other site 1173026006556 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 1173026006557 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173026006558 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1173026006559 putative homodimer interface [polypeptide binding]; other site 1173026006560 putative active site pocket [active] 1173026006561 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1173026006562 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1173026006563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026006564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026006565 homodimer interface [polypeptide binding]; other site 1173026006566 catalytic residue [active] 1173026006567 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1173026006568 RimM N-terminal domain; Region: RimM; pfam01782 1173026006569 PRC-barrel domain; Region: PRC; pfam05239 1173026006570 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1173026006571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026006572 Coenzyme A binding pocket [chemical binding]; other site 1173026006573 Predicted permeases [General function prediction only]; Region: COG0701 1173026006574 TIGR03943 family protein; Region: TIGR03943 1173026006575 Bacterial Ig-like domain; Region: Big_5; pfam13205 1173026006576 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1173026006577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1173026006578 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1173026006579 Probable transposase; Region: OrfB_IS605; pfam01385 1173026006580 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1173026006581 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1173026006582 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1173026006583 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1173026006584 active site 1173026006585 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 1173026006586 substrate binding site [chemical binding]; other site 1173026006587 homodimer interface [polypeptide binding]; other site 1173026006588 heme binding site [chemical binding]; other site 1173026006589 UV-endonuclease UvdE; Region: UvdE; cl10036 1173026006590 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1173026006591 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 1173026006592 nucleotide binding site [chemical binding]; other site 1173026006593 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1173026006594 SBD interface [polypeptide binding]; other site 1173026006595 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 1173026006596 Ferritin-like domain; Region: Ferritin; pfam00210 1173026006597 diiron binding motif [ion binding]; other site 1173026006598 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1173026006599 iron-sulfur cluster [ion binding]; other site 1173026006600 [2Fe-2S] cluster binding site [ion binding]; other site 1173026006601 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026006602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006604 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026006605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006607 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006609 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1173026006610 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1173026006611 active site 1173026006612 intersubunit interface [polypeptide binding]; other site 1173026006613 catalytic residue [active] 1173026006614 PRC-barrel domain; Region: PRC; pfam05239 1173026006615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173026006616 PRC-barrel domain; Region: PRC; pfam05239 1173026006617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 1173026006618 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1173026006619 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173026006620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026006621 Walker A motif; other site 1173026006622 ATP binding site [chemical binding]; other site 1173026006623 Walker B motif; other site 1173026006624 arginine finger; other site 1173026006625 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173026006626 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173026006627 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1173026006628 homodimer interface [polypeptide binding]; other site 1173026006629 substrate-cofactor binding pocket; other site 1173026006630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026006631 catalytic residue [active] 1173026006632 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1173026006633 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1173026006634 active site 1173026006635 catalytic residues [active] 1173026006636 metal binding site [ion binding]; metal-binding site 1173026006637 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1173026006638 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026006639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026006640 catalytic loop [active] 1173026006641 iron binding site [ion binding]; other site 1173026006642 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173026006643 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1173026006644 ThiS interaction site; other site 1173026006645 putative active site [active] 1173026006646 tetramer interface [polypeptide binding]; other site 1173026006647 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1173026006648 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1173026006649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026006650 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173026006651 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 1173026006652 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1173026006653 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173026006654 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1173026006655 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1173026006656 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006658 active site 1173026006659 phosphorylation site [posttranslational modification] 1173026006660 intermolecular recognition site; other site 1173026006661 dimerization interface [polypeptide binding]; other site 1173026006662 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006664 putative active site [active] 1173026006665 heme pocket [chemical binding]; other site 1173026006666 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006667 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006668 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006671 dimer interface [polypeptide binding]; other site 1173026006672 phosphorylation site [posttranslational modification] 1173026006673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006674 ATP binding site [chemical binding]; other site 1173026006675 Mg2+ binding site [ion binding]; other site 1173026006676 G-X-G motif; other site 1173026006677 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026006678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006679 active site 1173026006680 phosphorylation site [posttranslational modification] 1173026006681 intermolecular recognition site; other site 1173026006682 dimerization interface [polypeptide binding]; other site 1173026006683 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173026006684 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026006685 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026006686 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026006687 PAS domain S-box; Region: sensory_box; TIGR00229 1173026006688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026006689 putative active site [active] 1173026006690 heme pocket [chemical binding]; other site 1173026006691 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026006692 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026006693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006694 dimer interface [polypeptide binding]; other site 1173026006695 phosphorylation site [posttranslational modification] 1173026006696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006697 ATP binding site [chemical binding]; other site 1173026006698 Mg2+ binding site [ion binding]; other site 1173026006699 G-X-G motif; other site 1173026006700 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1173026006701 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1173026006702 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173026006703 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173026006704 BT1 family; Region: BT1; pfam03092 1173026006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026006706 putative substrate translocation pore; other site 1173026006707 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 1173026006708 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1173026006709 putative active site pocket [active] 1173026006710 4-fold oligomerization interface [polypeptide binding]; other site 1173026006711 metal binding residues [ion binding]; metal-binding site 1173026006712 3-fold/trimer interface [polypeptide binding]; other site 1173026006713 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 1173026006714 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1173026006715 NAD binding site [chemical binding]; other site 1173026006716 homotetramer interface [polypeptide binding]; other site 1173026006717 homodimer interface [polypeptide binding]; other site 1173026006718 substrate binding site [chemical binding]; other site 1173026006719 active site 1173026006720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026006721 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1173026006722 ligand binding site [chemical binding]; other site 1173026006723 flexible hinge region; other site 1173026006724 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026006725 putative switch regulator; other site 1173026006726 non-specific DNA interactions [nucleotide binding]; other site 1173026006727 DNA binding site [nucleotide binding] 1173026006728 sequence specific DNA binding site [nucleotide binding]; other site 1173026006729 putative cAMP binding site [chemical binding]; other site 1173026006730 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 1173026006731 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 1173026006732 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1173026006733 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 1173026006734 Dynamin family; Region: Dynamin_N; pfam00350 1173026006735 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173026006736 G1 box; other site 1173026006737 GTP/Mg2+ binding site [chemical binding]; other site 1173026006738 Switch I region; other site 1173026006739 G2 box; other site 1173026006740 Switch II region; other site 1173026006741 G3 box; other site 1173026006742 G4 box; other site 1173026006743 G5 box; other site 1173026006744 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173026006745 Conserved TM helix; Region: TM_helix; pfam05552 1173026006746 Conserved TM helix; Region: TM_helix; pfam05552 1173026006747 Conserved TM helix; Region: TM_helix; pfam05552 1173026006748 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1173026006749 hydrophobic ligand binding site; other site 1173026006750 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1173026006751 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1173026006752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026006753 binding surface 1173026006754 TPR motif; other site 1173026006755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026006756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026006757 dimerization interface [polypeptide binding]; other site 1173026006758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026006759 dimer interface [polypeptide binding]; other site 1173026006760 phosphorylation site [posttranslational modification] 1173026006761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026006762 ATP binding site [chemical binding]; other site 1173026006763 Mg2+ binding site [ion binding]; other site 1173026006764 G-X-G motif; other site 1173026006765 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026006766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026006767 active site 1173026006768 phosphorylation site [posttranslational modification] 1173026006769 intermolecular recognition site; other site 1173026006770 dimerization interface [polypeptide binding]; other site 1173026006771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026006772 DNA binding site [nucleotide binding] 1173026006773 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1173026006774 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1173026006775 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173026006776 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1173026006777 putative ADP-binding pocket [chemical binding]; other site 1173026006778 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1173026006779 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1173026006780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026006781 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1173026006782 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173026006783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026006784 active site 1173026006785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026006786 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026006787 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026006788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026006789 Walker A/P-loop; other site 1173026006790 ATP binding site [chemical binding]; other site 1173026006791 Q-loop/lid; other site 1173026006792 ABC transporter signature motif; other site 1173026006793 Walker B; other site 1173026006794 D-loop; other site 1173026006795 H-loop/switch region; other site 1173026006796 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026006797 catalytic core [active] 1173026006798 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026006799 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026006800 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1173026006801 putative NAD(P) binding site [chemical binding]; other site 1173026006802 active site 1173026006803 putative substrate binding site [chemical binding]; other site 1173026006804 FAD dependent oxidoreductase; Region: DAO; pfam01266 1173026006805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026006806 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 1173026006807 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173026006808 dimer interface [polypeptide binding]; other site 1173026006809 active site 1173026006810 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 1173026006811 active site 1173026006812 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 1173026006813 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 1173026006814 D1 interface; other site 1173026006815 chlorophyll binding site; other site 1173026006816 pheophytin binding site; other site 1173026006817 beta carotene binding site; other site 1173026006818 cytochrome b559 beta interface; other site 1173026006819 quinone binding site; other site 1173026006820 cytochrome b559 alpha interface; other site 1173026006821 protein J interface; other site 1173026006822 protein H interface; other site 1173026006823 protein X interface; other site 1173026006824 core light harvesting protein interface; other site 1173026006825 protein L interface; other site 1173026006826 CP43 interface; other site 1173026006827 protein T interface; other site 1173026006828 Fe binding site [ion binding]; other site 1173026006829 protein M interface; other site 1173026006830 Mn-stabilizing polypeptide interface; other site 1173026006831 bromide binding site; other site 1173026006832 cytochrome c-550 interface; other site 1173026006833 photosystem II 44 kDa protein; Region: psbC; CHL00035 1173026006834 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 1173026006835 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1173026006836 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1173026006837 putative active site [active] 1173026006838 putative metal binding site [ion binding]; other site 1173026006839 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173026006840 metal ion-dependent adhesion site (MIDAS); other site 1173026006841 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1173026006842 SWIM zinc finger; Region: SWIM; pfam04434 1173026006843 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1173026006844 SNF2 Helicase protein; Region: DUF3670; pfam12419 1173026006845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026006846 ATP binding site [chemical binding]; other site 1173026006847 putative Mg++ binding site [ion binding]; other site 1173026006848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026006849 nucleotide binding region [chemical binding]; other site 1173026006850 ATP-binding site [chemical binding]; other site 1173026006851 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1173026006852 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1173026006853 RNase E interface [polypeptide binding]; other site 1173026006854 trimer interface [polypeptide binding]; other site 1173026006855 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1173026006856 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1173026006857 RNase E interface [polypeptide binding]; other site 1173026006858 trimer interface [polypeptide binding]; other site 1173026006859 active site 1173026006860 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1173026006861 putative nucleic acid binding region [nucleotide binding]; other site 1173026006862 G-X-X-G motif; other site 1173026006863 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1173026006864 RNA binding site [nucleotide binding]; other site 1173026006865 domain interface; other site 1173026006866 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1173026006867 triosephosphate isomerase; Provisional; Region: PRK14565 1173026006868 substrate binding site [chemical binding]; other site 1173026006869 dimer interface [polypeptide binding]; other site 1173026006870 catalytic triad [active] 1173026006871 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1173026006872 dihydropteroate synthase; Region: DHPS; TIGR01496 1173026006873 substrate binding pocket [chemical binding]; other site 1173026006874 dimer interface [polypeptide binding]; other site 1173026006875 inhibitor binding site; inhibition site 1173026006876 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173026006877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173026006878 hypothetical protein; Validated; Region: PRK07411 1173026006879 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1173026006880 ATP binding site [chemical binding]; other site 1173026006881 substrate interface [chemical binding]; other site 1173026006882 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173026006883 active site residue [active] 1173026006884 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1173026006885 MPN+ (JAMM) motif; other site 1173026006886 Zinc-binding site [ion binding]; other site 1173026006887 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1173026006888 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173026006889 Walker A/P-loop; other site 1173026006890 ATP binding site [chemical binding]; other site 1173026006891 Q-loop/lid; other site 1173026006892 ABC transporter signature motif; other site 1173026006893 Walker B; other site 1173026006894 D-loop; other site 1173026006895 H-loop/switch region; other site 1173026006896 Ferredoxin [Energy production and conversion]; Region: COG1146 1173026006897 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1173026006898 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1173026006899 dimer interface [polypeptide binding]; other site 1173026006900 motif 1; other site 1173026006901 active site 1173026006902 motif 2; other site 1173026006903 motif 3; other site 1173026006904 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1173026006905 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026006906 HSP70 interaction site [polypeptide binding]; other site 1173026006907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026006908 binding surface 1173026006909 TPR repeat; Region: TPR_11; pfam13414 1173026006910 TPR motif; other site 1173026006911 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1173026006912 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173026006913 active site 1173026006914 dimerization interface [polypeptide binding]; other site 1173026006915 Staphylococcal nuclease homologues; Region: SNc; smart00318 1173026006916 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1173026006917 Catalytic site; other site 1173026006918 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026006919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026006920 catalytic loop [active] 1173026006921 iron binding site [ion binding]; other site 1173026006922 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 1173026006923 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1173026006924 RNA binding site [nucleotide binding]; other site 1173026006925 active site 1173026006926 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1173026006927 META domain; Region: META; pfam03724 1173026006928 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1173026006929 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1173026006930 Part of AAA domain; Region: AAA_19; pfam13245 1173026006931 Family description; Region: UvrD_C_2; pfam13538 1173026006932 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026006933 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 1173026006934 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026006935 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026006936 siderophore binding site; other site 1173026006937 AMIN domain; Region: AMIN; pfam11741 1173026006938 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026006939 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026006940 N-terminal plug; other site 1173026006941 ligand-binding site [chemical binding]; other site 1173026006942 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026006943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026006944 Predicted metal-binding protein [Function unknown]; Region: COG5469 1173026006945 Predicted membrane protein [Function unknown]; Region: COG4244 1173026006946 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173026006947 Hemerythrin family; Region: Hemerythrin-like; cl15774 1173026006948 Hemerythrin-like domain; Region: Hr-like; cd12108 1173026006949 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1173026006950 short chain dehydrogenase; Provisional; Region: PRK06701 1173026006951 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1173026006952 NAD binding site [chemical binding]; other site 1173026006953 metal binding site [ion binding]; metal-binding site 1173026006954 active site 1173026006955 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026006956 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1173026006957 Predicted membrane protein [Function unknown]; Region: COG1950 1173026006958 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173026006959 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026006960 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026006961 active site 1173026006962 ATP binding site [chemical binding]; other site 1173026006963 substrate binding site [chemical binding]; other site 1173026006964 activation loop (A-loop); other site 1173026006965 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026006966 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006967 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026006968 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026006969 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173026006970 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173026006971 metal binding site [ion binding]; metal-binding site 1173026006972 dimer interface [polypeptide binding]; other site 1173026006973 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1173026006974 MgtE intracellular N domain; Region: MgtE_N; smart00924 1173026006975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1173026006976 Divalent cation transporter; Region: MgtE; pfam01769 1173026006977 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 1173026006978 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1173026006979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026006980 Walker A motif; other site 1173026006981 ATP binding site [chemical binding]; other site 1173026006982 Walker B motif; other site 1173026006983 arginine finger; other site 1173026006984 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173026006985 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1173026006986 GntP family permease; Region: GntP_permease; pfam02447 1173026006987 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1173026006988 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1173026006989 N- and C-terminal domain interface [polypeptide binding]; other site 1173026006990 active site 1173026006991 catalytic site [active] 1173026006992 metal binding site [ion binding]; metal-binding site 1173026006993 carbohydrate binding site [chemical binding]; other site 1173026006994 ATP binding site [chemical binding]; other site 1173026006995 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026006996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026006997 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173026006998 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1173026006999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026007000 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173026007001 Walker A/P-loop; other site 1173026007002 ATP binding site [chemical binding]; other site 1173026007003 Q-loop/lid; other site 1173026007004 ABC transporter signature motif; other site 1173026007005 Walker B; other site 1173026007006 D-loop; other site 1173026007007 H-loop/switch region; other site 1173026007008 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1173026007009 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1173026007010 malonyl-CoA binding site [chemical binding]; other site 1173026007011 dimer interface [polypeptide binding]; other site 1173026007012 active site 1173026007013 product binding site; other site 1173026007014 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1173026007015 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173026007016 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173026007017 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173026007018 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173026007019 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1173026007020 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026007021 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026007022 siderophore binding site; other site 1173026007023 AMIN domain; Region: AMIN; pfam11741 1173026007024 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026007025 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026007026 N-terminal plug; other site 1173026007027 ligand-binding site [chemical binding]; other site 1173026007028 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026007029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026007030 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 1173026007031 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1173026007032 active site residue [active] 1173026007033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026007034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007035 active site 1173026007036 phosphorylation site [posttranslational modification] 1173026007037 intermolecular recognition site; other site 1173026007038 dimerization interface [polypeptide binding]; other site 1173026007039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026007040 DNA binding site [nucleotide binding] 1173026007041 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026007042 putative binding surface; other site 1173026007043 active site 1173026007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026007046 active site 1173026007047 phosphorylation site [posttranslational modification] 1173026007048 intermolecular recognition site; other site 1173026007049 dimerization interface [polypeptide binding]; other site 1173026007050 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007052 active site 1173026007053 phosphorylation site [posttranslational modification] 1173026007054 intermolecular recognition site; other site 1173026007055 dimerization interface [polypeptide binding]; other site 1173026007056 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026007057 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026007058 metal binding site [ion binding]; metal-binding site 1173026007059 active site 1173026007060 I-site; other site 1173026007061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007062 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026007063 putative active site [active] 1173026007064 heme pocket [chemical binding]; other site 1173026007065 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026007066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007067 putative active site [active] 1173026007068 heme pocket [chemical binding]; other site 1173026007069 PAS domain S-box; Region: sensory_box; TIGR00229 1173026007070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007071 putative active site [active] 1173026007072 heme pocket [chemical binding]; other site 1173026007073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026007074 dimer interface [polypeptide binding]; other site 1173026007075 phosphorylation site [posttranslational modification] 1173026007076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007077 ATP binding site [chemical binding]; other site 1173026007078 Mg2+ binding site [ion binding]; other site 1173026007079 G-X-G motif; other site 1173026007080 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007082 active site 1173026007083 phosphorylation site [posttranslational modification] 1173026007084 intermolecular recognition site; other site 1173026007085 dimerization interface [polypeptide binding]; other site 1173026007086 Domain of unknown function (DUF202); Region: DUF202; cl09954 1173026007087 Domain of unknown function (DUF202); Region: DUF202; cl09954 1173026007088 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1173026007089 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1173026007090 transmembrane helices; other site 1173026007091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026007092 dimerization interface [polypeptide binding]; other site 1173026007093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007094 ATP binding site [chemical binding]; other site 1173026007095 Mg2+ binding site [ion binding]; other site 1173026007096 G-X-G motif; other site 1173026007097 glycerate kinase; Region: TIGR00045 1173026007098 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 1173026007099 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1173026007100 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1173026007101 Active_site [active] 1173026007102 AMIN domain; Region: AMIN; pfam11741 1173026007103 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 1173026007104 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173026007105 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173026007106 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1173026007107 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173026007108 active site 1173026007109 catalytic triad [active] 1173026007110 oxyanion hole [active] 1173026007111 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1173026007112 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 1173026007113 L-aspartate oxidase; Provisional; Region: PRK06175 1173026007114 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173026007115 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 1173026007116 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1173026007117 alpha subunit interface [polypeptide binding]; other site 1173026007118 TPP binding site [chemical binding]; other site 1173026007119 heterodimer interface [polypeptide binding]; other site 1173026007120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1173026007121 protein-export membrane protein SecD; Region: secD; TIGR01129 1173026007122 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1173026007123 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1173026007124 Protein export membrane protein; Region: SecD_SecF; pfam02355 1173026007125 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1173026007126 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1173026007127 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173026007128 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173026007129 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1173026007130 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1173026007131 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1173026007132 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1173026007133 Walker A/P-loop; other site 1173026007134 ATP binding site [chemical binding]; other site 1173026007135 Q-loop/lid; other site 1173026007136 ABC transporter signature motif; other site 1173026007137 Walker B; other site 1173026007138 D-loop; other site 1173026007139 H-loop/switch region; other site 1173026007140 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1173026007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026007142 dimer interface [polypeptide binding]; other site 1173026007143 conserved gate region; other site 1173026007144 putative PBP binding loops; other site 1173026007145 ABC-ATPase subunit interface; other site 1173026007146 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173026007147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026007148 dimer interface [polypeptide binding]; other site 1173026007149 conserved gate region; other site 1173026007150 putative PBP binding loops; other site 1173026007151 ABC-ATPase subunit interface; other site 1173026007152 phosphate binding protein; Region: ptsS_2; TIGR02136 1173026007153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026007154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026007155 Coenzyme A binding pocket [chemical binding]; other site 1173026007156 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1173026007157 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173026007158 active site 1173026007159 HIGH motif; other site 1173026007160 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1173026007161 active site 1173026007162 KMSKS motif; other site 1173026007163 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1173026007164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1173026007165 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1173026007166 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1173026007167 RNase_H superfamily; Region: RNase_H_2; pfam13482 1173026007168 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173026007169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173026007170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026007171 catalytic residue [active] 1173026007172 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1173026007173 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1173026007174 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1173026007175 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1173026007176 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1173026007177 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173026007178 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1173026007179 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 1173026007180 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1173026007181 active site 1173026007182 DNA binding site [nucleotide binding] 1173026007183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026007184 dimerization interface [polypeptide binding]; other site 1173026007185 putative DNA binding site [nucleotide binding]; other site 1173026007186 putative Zn2+ binding site [ion binding]; other site 1173026007187 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1173026007188 putative hydrophobic ligand binding site [chemical binding]; other site 1173026007189 Clp protease; Region: CLP_protease; pfam00574 1173026007190 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173026007191 oligomer interface [polypeptide binding]; other site 1173026007192 active site residues [active] 1173026007193 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026007194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026007195 NAD(P) binding site [chemical binding]; other site 1173026007196 active site 1173026007197 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026007198 active site 1173026007199 catalytic residues [active] 1173026007200 DNA binding site [nucleotide binding] 1173026007201 Int/Topo IB signature motif; other site 1173026007202 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1173026007203 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1173026007204 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1173026007205 S-adenosylmethionine binding site [chemical binding]; other site 1173026007206 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 1173026007207 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173026007208 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1173026007209 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 1173026007210 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 1173026007211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007213 active site 1173026007214 phosphorylation site [posttranslational modification] 1173026007215 intermolecular recognition site; other site 1173026007216 dimerization interface [polypeptide binding]; other site 1173026007217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026007218 DNA binding site [nucleotide binding] 1173026007219 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 1173026007220 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173026007221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026007222 motif II; other site 1173026007223 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1173026007224 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1173026007225 dimer interface [polypeptide binding]; other site 1173026007226 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1173026007227 active site 1173026007228 Fe binding site [ion binding]; other site 1173026007229 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173026007230 classical (c) SDRs; Region: SDR_c; cd05233 1173026007231 NAD(P) binding site [chemical binding]; other site 1173026007232 active site 1173026007233 cell division protein; Validated; Region: ftsH; CHL00176 1173026007234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026007235 Walker A motif; other site 1173026007236 ATP binding site [chemical binding]; other site 1173026007237 Walker B motif; other site 1173026007238 arginine finger; other site 1173026007239 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173026007240 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 1173026007241 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173026007242 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026007243 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026007244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026007245 DNA binding residues [nucleotide binding] 1173026007246 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173026007247 metal binding site 2 [ion binding]; metal-binding site 1173026007248 putative DNA binding helix; other site 1173026007249 metal binding site 1 [ion binding]; metal-binding site 1173026007250 dimer interface [polypeptide binding]; other site 1173026007251 structural Zn2+ binding site [ion binding]; other site 1173026007252 Bacterial SH3 domain; Region: SH3_3; cl17532 1173026007253 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1173026007254 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1173026007255 Probable Catalytic site; other site 1173026007256 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1173026007257 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 1173026007258 Hexamer interface [polypeptide binding]; other site 1173026007259 Hexagonal pore residue; other site 1173026007260 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173026007261 active site residue [active] 1173026007262 heat shock protein HtpX; Provisional; Region: PRK03982 1173026007263 Domain of unknown function DUF39; Region: DUF39; pfam01837 1173026007264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026007265 TPR motif; other site 1173026007266 binding surface 1173026007267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026007268 binding surface 1173026007269 TPR motif; other site 1173026007270 Predicted membrane protein [Function unknown]; Region: COG2119 1173026007271 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173026007272 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173026007273 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1173026007274 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1173026007275 putative homodimer interface [polypeptide binding]; other site 1173026007276 putative active site pocket [active] 1173026007277 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1173026007278 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 1173026007279 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1173026007280 OstA-like protein; Region: OstA; cl00844 1173026007281 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 1173026007282 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173026007283 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1173026007284 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026007285 Ligand Binding Site [chemical binding]; other site 1173026007286 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1173026007287 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1173026007288 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1173026007289 active site 1173026007290 catalytic site [active] 1173026007291 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1173026007292 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026007293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026007294 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026007295 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173026007296 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1173026007297 Protein of unknown function (DUF497); Region: DUF497; cl01108 1173026007298 Protein of unknown function (DUF497); Region: DUF497; cl01108 1173026007299 AMIN domain; Region: AMIN; pfam11741 1173026007300 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026007301 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026007302 N-terminal plug; other site 1173026007303 ligand-binding site [chemical binding]; other site 1173026007304 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026007305 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026007306 siderophore binding site; other site 1173026007307 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173026007308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026007309 S-adenosylmethionine binding site [chemical binding]; other site 1173026007310 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 1173026007311 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 1173026007312 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 1173026007313 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1173026007314 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1173026007315 putative active site [active] 1173026007316 catalytic residue [active] 1173026007317 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1173026007318 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173026007319 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173026007320 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1173026007321 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1173026007322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173026007323 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173026007324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026007325 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173026007326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026007327 motif II; other site 1173026007328 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173026007329 recombination protein F; Reviewed; Region: recF; PRK00064 1173026007330 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1173026007331 Walker A/P-loop; other site 1173026007332 ATP binding site [chemical binding]; other site 1173026007333 Q-loop/lid; other site 1173026007334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026007335 ABC transporter signature motif; other site 1173026007336 Walker B; other site 1173026007337 D-loop; other site 1173026007338 H-loop/switch region; other site 1173026007339 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1173026007340 MgtC family; Region: MgtC; pfam02308 1173026007341 CHASE domain; Region: CHASE; pfam03924 1173026007342 PAS domain S-box; Region: sensory_box; TIGR00229 1173026007343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007344 putative active site [active] 1173026007345 heme pocket [chemical binding]; other site 1173026007346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026007347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026007348 dimer interface [polypeptide binding]; other site 1173026007349 phosphorylation site [posttranslational modification] 1173026007350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007351 ATP binding site [chemical binding]; other site 1173026007352 Mg2+ binding site [ion binding]; other site 1173026007353 G-X-G motif; other site 1173026007354 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1173026007355 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173026007356 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173026007357 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173026007358 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173026007359 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026007360 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007362 active site 1173026007363 phosphorylation site [posttranslational modification] 1173026007364 intermolecular recognition site; other site 1173026007365 dimerization interface [polypeptide binding]; other site 1173026007366 PAS domain S-box; Region: sensory_box; TIGR00229 1173026007367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007368 putative active site [active] 1173026007369 heme pocket [chemical binding]; other site 1173026007370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026007371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026007372 dimer interface [polypeptide binding]; other site 1173026007373 phosphorylation site [posttranslational modification] 1173026007374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007375 ATP binding site [chemical binding]; other site 1173026007376 Mg2+ binding site [ion binding]; other site 1173026007377 G-X-G motif; other site 1173026007378 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173026007379 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173026007380 CHASE3 domain; Region: CHASE3; pfam05227 1173026007381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026007382 dimerization interface [polypeptide binding]; other site 1173026007383 GAF domain; Region: GAF_2; pfam13185 1173026007384 GAF domain; Region: GAF_3; pfam13492 1173026007385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026007386 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1173026007387 dimer interface [polypeptide binding]; other site 1173026007388 phosphorylation site [posttranslational modification] 1173026007389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007390 ATP binding site [chemical binding]; other site 1173026007391 Mg2+ binding site [ion binding]; other site 1173026007392 G-X-G motif; other site 1173026007393 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007395 active site 1173026007396 phosphorylation site [posttranslational modification] 1173026007397 intermolecular recognition site; other site 1173026007398 dimerization interface [polypeptide binding]; other site 1173026007399 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026007400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007401 active site 1173026007402 phosphorylation site [posttranslational modification] 1173026007403 intermolecular recognition site; other site 1173026007404 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007406 active site 1173026007407 phosphorylation site [posttranslational modification] 1173026007408 intermolecular recognition site; other site 1173026007409 dimerization interface [polypeptide binding]; other site 1173026007410 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1173026007411 G1 box; other site 1173026007412 GTP/Mg2+ binding site [chemical binding]; other site 1173026007413 G2 box; other site 1173026007414 Switch I region; other site 1173026007415 G3 box; other site 1173026007416 Switch II region; other site 1173026007417 G4 box; other site 1173026007418 G5 box; other site 1173026007419 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1173026007420 UreF; Region: UreF; pfam01730 1173026007421 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1173026007422 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1173026007423 dimer interface [polypeptide binding]; other site 1173026007424 catalytic residues [active] 1173026007425 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1173026007426 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1173026007427 quinone interaction residues [chemical binding]; other site 1173026007428 active site 1173026007429 catalytic residues [active] 1173026007430 FMN binding site [chemical binding]; other site 1173026007431 substrate binding site [chemical binding]; other site 1173026007432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026007433 S-adenosylmethionine binding site [chemical binding]; other site 1173026007434 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026007435 active site 1173026007436 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1173026007437 Fe-S cluster binding site [ion binding]; other site 1173026007438 active site 1173026007439 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1173026007440 active site 1173026007441 dimer interface [polypeptide binding]; other site 1173026007442 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1173026007443 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1173026007444 active site 1173026007445 HIGH motif; other site 1173026007446 dimer interface [polypeptide binding]; other site 1173026007447 KMSKS motif; other site 1173026007448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1173026007449 Transglycosylase; Region: Transgly; pfam00912 1173026007450 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1173026007451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173026007452 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 1173026007453 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1173026007454 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173026007455 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173026007456 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1173026007457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1173026007458 Catalytic site [active] 1173026007459 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1173026007460 MoaE homodimer interface [polypeptide binding]; other site 1173026007461 MoaD interaction [polypeptide binding]; other site 1173026007462 active site residues [active] 1173026007463 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 1173026007464 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1173026007465 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1173026007466 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1173026007467 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1173026007468 DNA binding site [nucleotide binding] 1173026007469 domain linker motif; other site 1173026007470 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1173026007471 putative dimerization interface [polypeptide binding]; other site 1173026007472 putative ligand binding site [chemical binding]; other site 1173026007473 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 1173026007474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026007475 FeS/SAM binding site; other site 1173026007476 HemN C-terminal domain; Region: HemN_C; pfam06969 1173026007477 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1173026007478 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1173026007479 putative active site [active] 1173026007480 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1173026007481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026007482 putative metal binding site [ion binding]; other site 1173026007483 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026007484 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026007485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007486 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173026007487 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1173026007488 FtsH Extracellular; Region: FtsH_ext; pfam06480 1173026007489 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1173026007490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026007491 Walker A motif; other site 1173026007492 ATP binding site [chemical binding]; other site 1173026007493 Walker B motif; other site 1173026007494 arginine finger; other site 1173026007495 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173026007496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026007497 S-adenosylmethionine binding site [chemical binding]; other site 1173026007498 putative high light inducible protein; Region: PHA02337 1173026007499 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 1173026007500 50S ribosomal protein L37Ae; Reviewed; Region: rpl37ae; PRK03976 1173026007501 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173026007502 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1173026007503 B12 binding site [chemical binding]; other site 1173026007504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026007505 FeS/SAM binding site; other site 1173026007506 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173026007507 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173026007508 Fasciclin domain; Region: Fasciclin; pfam02469 1173026007509 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1173026007510 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173026007511 metal ion-dependent adhesion site (MIDAS); other site 1173026007512 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1173026007513 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173026007514 oligomer interface [polypeptide binding]; other site 1173026007515 active site residues [active] 1173026007516 Clp protease; Region: CLP_protease; pfam00574 1173026007517 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173026007518 oligomer interface [polypeptide binding]; other site 1173026007519 active site residues [active] 1173026007520 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026007521 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173026007522 HSP70 interaction site [polypeptide binding]; other site 1173026007523 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026007524 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1173026007525 MoaE interaction surface [polypeptide binding]; other site 1173026007526 MoeB interaction surface [polypeptide binding]; other site 1173026007527 thiocarboxylated glycine; other site 1173026007528 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173026007529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026007530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026007531 dimer interface [polypeptide binding]; other site 1173026007532 conserved gate region; other site 1173026007533 putative PBP binding loops; other site 1173026007534 ABC-ATPase subunit interface; other site 1173026007535 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1173026007536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026007537 dimer interface [polypeptide binding]; other site 1173026007538 conserved gate region; other site 1173026007539 putative PBP binding loops; other site 1173026007540 ABC-ATPase subunit interface; other site 1173026007541 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1173026007542 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1173026007543 NAD(P) binding site [chemical binding]; other site 1173026007544 catalytic residues [active] 1173026007545 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173026007546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026007547 Walker A/P-loop; other site 1173026007548 ATP binding site [chemical binding]; other site 1173026007549 Q-loop/lid; other site 1173026007550 ABC transporter signature motif; other site 1173026007551 Walker B; other site 1173026007552 D-loop; other site 1173026007553 H-loop/switch region; other site 1173026007554 TOBE domain; Region: TOBE_2; pfam08402 1173026007555 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026007556 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026007557 active site 1173026007558 metal binding site [ion binding]; metal-binding site 1173026007559 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1173026007560 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1173026007561 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1173026007562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026007563 S-adenosylmethionine binding site [chemical binding]; other site 1173026007564 glutamine synthetase, type I; Region: GlnA; TIGR00653 1173026007565 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1173026007566 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173026007567 allophycocyanin, beta subunit; Region: apcB; TIGR01337 1173026007568 hypothetical protein; Validated; Region: PRK07198 1173026007569 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1173026007570 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1173026007571 dimerization interface [polypeptide binding]; other site 1173026007572 active site 1173026007573 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1173026007574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026007575 active site 1173026007576 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 1173026007577 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1173026007578 Na binding site [ion binding]; other site 1173026007579 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026007580 Chain length determinant protein; Region: Wzz; pfam02706 1173026007581 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173026007582 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173026007583 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026007584 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026007585 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1173026007586 metal-binding site 1173026007587 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026007588 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173026007589 active site 1173026007590 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026007591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026007592 active site 1173026007593 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1173026007594 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 1173026007595 putative ADP-binding pocket [chemical binding]; other site 1173026007596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026007597 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173026007598 O-Antigen ligase; Region: Wzy_C; pfam04932 1173026007599 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026007600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026007601 active site 1173026007602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026007603 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173026007604 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173026007605 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1173026007606 Right handed beta helix region; Region: Beta_helix; pfam13229 1173026007607 Right handed beta helix region; Region: Beta_helix; pfam13229 1173026007608 Right handed beta helix region; Region: Beta_helix; pfam13229 1173026007609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026007610 Coenzyme A binding pocket [chemical binding]; other site 1173026007611 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1173026007612 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 1173026007613 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 1173026007614 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 1173026007615 Rubredoxin [Energy production and conversion]; Region: COG1773 1173026007616 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1173026007617 iron binding site [ion binding]; other site 1173026007618 Ycf48-like protein; Provisional; Region: PRK13684 1173026007619 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 1173026007620 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 1173026007621 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 1173026007622 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 1173026007623 photosystem II reaction center protein J; Provisional; Region: PRK02565 1173026007624 photosystem I subunit VIII; Validated; Region: psaI; CHL00186 1173026007625 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1173026007626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026007627 active site 1173026007628 metal binding site [ion binding]; metal-binding site 1173026007629 Peptidase family M48; Region: Peptidase_M48; pfam01435 1173026007630 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 1173026007631 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026007632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026007633 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173026007634 catalytic site [active] 1173026007635 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1173026007636 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1173026007637 NodB motif; other site 1173026007638 active site 1173026007639 catalytic site [active] 1173026007640 metal binding site [ion binding]; metal-binding site 1173026007641 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 1173026007642 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173026007643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026007644 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026007645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026007646 DNA binding residues [nucleotide binding] 1173026007647 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173026007648 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173026007649 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173026007650 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1173026007651 Walker A/P-loop; other site 1173026007652 ATP binding site [chemical binding]; other site 1173026007653 Q-loop/lid; other site 1173026007654 ABC transporter signature motif; other site 1173026007655 Walker B; other site 1173026007656 D-loop; other site 1173026007657 H-loop/switch region; other site 1173026007658 TOBE domain; Region: TOBE_2; pfam08402 1173026007659 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1173026007660 Protein of unknown function (DUF565); Region: DUF565; pfam04483 1173026007661 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173026007662 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173026007663 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1173026007664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026007665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026007666 dimer interface [polypeptide binding]; other site 1173026007667 phosphorylation site [posttranslational modification] 1173026007668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007669 ATP binding site [chemical binding]; other site 1173026007670 Mg2+ binding site [ion binding]; other site 1173026007671 G-X-G motif; other site 1173026007672 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007674 active site 1173026007675 phosphorylation site [posttranslational modification] 1173026007676 intermolecular recognition site; other site 1173026007677 dimerization interface [polypeptide binding]; other site 1173026007678 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173026007679 tetramer interface [polypeptide binding]; other site 1173026007680 dimer interface [polypeptide binding]; other site 1173026007681 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 1173026007682 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173026007683 Walker A motif; other site 1173026007684 ATP binding site [chemical binding]; other site 1173026007685 Walker B motif; other site 1173026007686 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173026007687 ATP binding site [chemical binding]; other site 1173026007688 Walker B motif; other site 1173026007689 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1173026007690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026007691 Walker A/P-loop; other site 1173026007692 ATP binding site [chemical binding]; other site 1173026007693 Q-loop/lid; other site 1173026007694 ABC transporter signature motif; other site 1173026007695 Walker B; other site 1173026007696 D-loop; other site 1173026007697 H-loop/switch region; other site 1173026007698 ABC transporter; Region: ABC_tran_2; pfam12848 1173026007699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1173026007700 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1173026007701 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1173026007702 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1173026007703 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1173026007704 putative NADH binding site [chemical binding]; other site 1173026007705 putative active site [active] 1173026007706 nudix motif; other site 1173026007707 putative metal binding site [ion binding]; other site 1173026007708 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1173026007709 active site 1173026007710 SUMO-1 interface [polypeptide binding]; other site 1173026007711 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1173026007712 metal ion-dependent adhesion site (MIDAS); other site 1173026007713 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1173026007714 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1173026007715 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1173026007716 substrate binding site [chemical binding]; other site 1173026007717 activation loop (A-loop); other site 1173026007718 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 1173026007719 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173026007720 LysE type translocator; Region: LysE; pfam01810 1173026007721 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1173026007722 Glucose inhibited division protein A; Region: GIDA; pfam01134 1173026007723 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1173026007724 Peptidase family M50; Region: Peptidase_M50; pfam02163 1173026007725 active site 1173026007726 putative substrate binding region [chemical binding]; other site 1173026007727 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1173026007728 carboxyl-terminal processing protease; Provisional; Region: PLN00049 1173026007729 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1173026007730 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173026007731 protein binding site [polypeptide binding]; other site 1173026007732 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173026007733 Catalytic dyad [active] 1173026007734 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173026007735 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1173026007736 Qi binding site; other site 1173026007737 intrachain domain interface; other site 1173026007738 interchain domain interface [polypeptide binding]; other site 1173026007739 heme bH binding site [chemical binding]; other site 1173026007740 heme bL binding site [chemical binding]; other site 1173026007741 Qo binding site; other site 1173026007742 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173026007743 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1173026007744 interchain domain interface [polypeptide binding]; other site 1173026007745 intrachain domain interface; other site 1173026007746 Qi binding site; other site 1173026007747 Qo binding site; other site 1173026007748 RDD family; Region: RDD; pfam06271 1173026007749 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026007750 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007751 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007753 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026007755 dimerization interface [polypeptide binding]; other site 1173026007756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007757 PAS domain; Region: PAS_9; pfam13426 1173026007758 putative active site [active] 1173026007759 heme pocket [chemical binding]; other site 1173026007760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026007761 PAS fold; Region: PAS_3; pfam08447 1173026007762 putative active site [active] 1173026007763 heme pocket [chemical binding]; other site 1173026007764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026007765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026007766 metal binding site [ion binding]; metal-binding site 1173026007767 active site 1173026007768 I-site; other site 1173026007769 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026007770 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1173026007771 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1173026007772 ATP binding site [chemical binding]; other site 1173026007773 active site 1173026007774 substrate binding site [chemical binding]; other site 1173026007775 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173026007776 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173026007777 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173026007778 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1173026007779 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1173026007780 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1173026007781 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1173026007782 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1173026007783 active site 1173026007784 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1173026007785 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1173026007786 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1173026007787 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173026007788 cofactor binding site; other site 1173026007789 DNA binding site [nucleotide binding] 1173026007790 substrate interaction site [chemical binding]; other site 1173026007791 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173026007792 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007794 active site 1173026007795 phosphorylation site [posttranslational modification] 1173026007796 intermolecular recognition site; other site 1173026007797 dimerization interface [polypeptide binding]; other site 1173026007798 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026007799 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026007800 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026007801 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026007802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026007803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026007804 dimer interface [polypeptide binding]; other site 1173026007805 phosphorylation site [posttranslational modification] 1173026007806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026007807 ATP binding site [chemical binding]; other site 1173026007808 Mg2+ binding site [ion binding]; other site 1173026007809 G-X-G motif; other site 1173026007810 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026007811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026007812 active site 1173026007813 phosphorylation site [posttranslational modification] 1173026007814 intermolecular recognition site; other site 1173026007815 dimerization interface [polypeptide binding]; other site 1173026007816 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1173026007817 cyclase homology domain; Region: CHD; cd07302 1173026007818 nucleotidyl binding site; other site 1173026007819 metal binding site [ion binding]; metal-binding site 1173026007820 dimer interface [polypeptide binding]; other site 1173026007821 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1173026007822 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1173026007823 G1 box; other site 1173026007824 putative GEF interaction site [polypeptide binding]; other site 1173026007825 GTP/Mg2+ binding site [chemical binding]; other site 1173026007826 Switch I region; other site 1173026007827 G2 box; other site 1173026007828 G3 box; other site 1173026007829 Switch II region; other site 1173026007830 G4 box; other site 1173026007831 G5 box; other site 1173026007832 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1173026007833 Tic20-like protein; Region: Tic20; pfam09685 1173026007834 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1173026007835 dimer interface [polypeptide binding]; other site 1173026007836 active site 1173026007837 Schiff base residues; other site 1173026007838 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026007839 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026007840 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026007841 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173026007842 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173026007843 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1173026007844 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1173026007845 metal binding site [ion binding]; metal-binding site 1173026007846 S-layer homology domain; Region: SLH; pfam00395 1173026007847 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026007848 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1173026007849 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1173026007850 hypothetical protein; Provisional; Region: PRK04323 1173026007851 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1173026007852 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1173026007853 catalytic site [active] 1173026007854 G-X2-G-X-G-K; other site 1173026007855 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 1173026007856 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 1173026007857 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 1173026007858 UGMP family protein; Validated; Region: PRK09604 1173026007859 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1173026007860 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026007861 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173026007862 catalytic site [active] 1173026007863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026007864 Coenzyme A binding pocket [chemical binding]; other site 1173026007865 Tic22-like family; Region: Tic22; pfam04278 1173026007866 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1173026007867 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026007868 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1173026007869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026007870 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026007871 dimer interface [polypeptide binding]; other site 1173026007872 phosphorylation site [posttranslational modification] 1173026007873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026007874 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026007875 Coenzyme A binding pocket [chemical binding]; other site 1173026007876 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1173026007877 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1173026007878 active site 1173026007879 catalytic site [active] 1173026007880 tetramer interface [polypeptide binding]; other site 1173026007881 comF family protein; Region: comF; TIGR00201 1173026007882 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026007883 active site 1173026007884 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173026007885 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1173026007886 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1173026007887 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1173026007888 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1173026007889 Amino acid permease; Region: AA_permease_2; pfam13520 1173026007890 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026007891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026007892 S-adenosylmethionine binding site [chemical binding]; other site 1173026007893 photosystem II protein K; Region: psbK; CHL00047 1173026007894 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173026007895 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173026007896 putative C-terminal domain interface [polypeptide binding]; other site 1173026007897 putative GSH binding site (G-site) [chemical binding]; other site 1173026007898 putative dimer interface [polypeptide binding]; other site 1173026007899 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1173026007900 N-terminal domain interface [polypeptide binding]; other site 1173026007901 dimer interface [polypeptide binding]; other site 1173026007902 substrate binding pocket (H-site) [chemical binding]; other site 1173026007903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026007904 binding surface 1173026007905 TPR repeat; Region: TPR_11; pfam13414 1173026007906 TPR motif; other site 1173026007907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026007908 TPR motif; other site 1173026007909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026007910 binding surface 1173026007911 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1173026007912 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173026007913 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173026007914 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173026007915 DNA methylase; Region: N6_N4_Mtase; pfam01555 1173026007916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026007917 non-specific DNA binding site [nucleotide binding]; other site 1173026007918 salt bridge; other site 1173026007919 sequence-specific DNA binding site [nucleotide binding]; other site 1173026007920 Restriction endonuclease PvuII; Region: Endonuc-PvuII; pfam09225 1173026007921 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1173026007922 putative active site [active] 1173026007923 homotetrameric interface [polypeptide binding]; other site 1173026007924 metal binding site [ion binding]; metal-binding site 1173026007925 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1173026007926 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1173026007927 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173026007928 Membrane transport protein; Region: Mem_trans; cl09117 1173026007929 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1173026007930 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026007931 active site 1173026007932 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1173026007933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026007934 putative substrate translocation pore; other site 1173026007935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173026007936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026007937 Coenzyme A binding pocket [chemical binding]; other site 1173026007938 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173026007939 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1173026007940 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173026007941 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1173026007942 putative NAD(P) binding site [chemical binding]; other site 1173026007943 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1173026007944 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1173026007945 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1173026007946 substrate binding site [chemical binding]; other site 1173026007947 ligand binding site [chemical binding]; other site 1173026007948 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173026007949 endonuclease III; Region: ENDO3c; smart00478 1173026007950 minor groove reading motif; other site 1173026007951 helix-hairpin-helix signature motif; other site 1173026007952 substrate binding pocket [chemical binding]; other site 1173026007953 active site 1173026007954 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026007955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007956 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026007957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026007958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026007959 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 1173026007960 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1173026007961 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026007962 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026007963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026007964 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173026007965 Walker A/P-loop; other site 1173026007966 ATP binding site [chemical binding]; other site 1173026007967 Q-loop/lid; other site 1173026007968 ABC transporter signature motif; other site 1173026007969 Walker B; other site 1173026007970 D-loop; other site 1173026007971 H-loop/switch region; other site 1173026007972 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026007973 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173026007974 Walker A/P-loop; other site 1173026007975 ATP binding site [chemical binding]; other site 1173026007976 Q-loop/lid; other site 1173026007977 ABC transporter signature motif; other site 1173026007978 Walker B; other site 1173026007979 D-loop; other site 1173026007980 H-loop/switch region; other site 1173026007981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173026007982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026007983 Coenzyme A binding pocket [chemical binding]; other site 1173026007984 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173026007985 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173026007986 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173026007987 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1173026007988 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1173026007989 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1173026007990 putative substrate binding site [chemical binding]; other site 1173026007991 putative ATP binding site [chemical binding]; other site 1173026007992 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1173026007993 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173026007994 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1173026007995 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1173026007996 Protein of unknown function (DUF561); Region: DUF561; pfam04481 1173026007997 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173026007998 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173026007999 inhibitor-cofactor binding pocket; inhibition site 1173026008000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026008001 catalytic residue [active] 1173026008002 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1173026008003 short chain dehydrogenase; Validated; Region: PRK06182 1173026008004 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1173026008005 NADP binding site [chemical binding]; other site 1173026008006 active site 1173026008007 steroid binding site; other site 1173026008008 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1173026008009 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1173026008010 CoA-ligase; Region: Ligase_CoA; pfam00549 1173026008011 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1173026008012 CoA binding domain; Region: CoA_binding; smart00881 1173026008013 CoA-ligase; Region: Ligase_CoA; pfam00549 1173026008014 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 1173026008015 active site 1173026008016 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026008017 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026008018 structural tetrad; other site 1173026008019 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1173026008020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1173026008021 active site 1173026008022 motif I; other site 1173026008023 motif II; other site 1173026008024 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026008025 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173026008026 Walker A/P-loop; other site 1173026008027 ATP binding site [chemical binding]; other site 1173026008028 Q-loop/lid; other site 1173026008029 ABC transporter signature motif; other site 1173026008030 Walker B; other site 1173026008031 D-loop; other site 1173026008032 H-loop/switch region; other site 1173026008033 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1173026008034 tartrate dehydrogenase; Region: TTC; TIGR02089 1173026008035 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1173026008036 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1173026008037 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1173026008038 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1173026008039 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1173026008040 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1173026008041 cytochrome c-550; Provisional; Region: psbV; PRK13618 1173026008042 cytochrome c-550; Provisional; Region: psbV; PRK13621 1173026008043 cytochrome c-550; Provisional; Region: psbV; cl17239 1173026008044 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1173026008045 plastocyanin; Provisional; Region: PRK02710 1173026008046 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173026008047 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1173026008048 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1173026008049 active site 1173026008050 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1173026008051 Orotate phosphoribosyltransferase homologs [Nucleotide transport and metabolism]; Region: COG0856 1173026008052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026008053 active site 1173026008054 cytosine deaminase; Provisional; Region: PRK05985 1173026008055 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1173026008056 active site 1173026008057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1173026008058 NMT1/THI5 like; Region: NMT1; pfam09084 1173026008059 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1173026008060 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026008061 DNA-binding site [nucleotide binding]; DNA binding site 1173026008062 FCD domain; Region: FCD; pfam07729 1173026008063 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 1173026008064 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1173026008065 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 1173026008066 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026008067 putative active site [active] 1173026008068 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 1173026008069 Restriction endonuclease BamHI; Region: BamHI; pfam02923 1173026008070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026008071 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173026008072 DNA methylase; Region: N6_N4_Mtase; pfam01555 1173026008073 Helix-turn-helix domain; Region: HTH_17; pfam12728 1173026008074 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1173026008075 S-layer homology domain; Region: SLH; pfam00395 1173026008076 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173026008077 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173026008078 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1173026008079 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173026008080 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1173026008081 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1173026008082 dimer interface [polypeptide binding]; other site 1173026008083 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1173026008084 catalytic triad [active] 1173026008085 peroxidatic and resolving cysteines [active] 1173026008086 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1173026008087 putative catalytic residues [active] 1173026008088 chaperone protein DnaJ; Provisional; Region: PRK14299 1173026008089 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026008090 HSP70 interaction site [polypeptide binding]; other site 1173026008091 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1173026008092 substrate binding site [polypeptide binding]; other site 1173026008093 dimer interface [polypeptide binding]; other site 1173026008094 AAA domain; Region: AAA_33; pfam13671 1173026008095 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 1173026008096 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 1173026008097 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1173026008098 ligand binding site; other site 1173026008099 oligomer interface; other site 1173026008100 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1173026008101 dimer interface [polypeptide binding]; other site 1173026008102 N-terminal domain interface [polypeptide binding]; other site 1173026008103 sulfate 1 binding site; other site 1173026008104 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1173026008105 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1173026008106 active site 1173026008107 homodimer interface [polypeptide binding]; other site 1173026008108 catalytic site [active] 1173026008109 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1173026008110 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173026008111 Fasciclin domain; Region: Fasciclin; pfam02469 1173026008112 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 1173026008113 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 1173026008114 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1173026008115 hypothetical protein; Provisional; Region: PRK06185 1173026008116 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173026008117 MgtE intracellular N domain; Region: MgtE_N; cl15244 1173026008118 Divalent cation transporter; Region: MgtE; pfam01769 1173026008119 Predicted membrane protein [Function unknown]; Region: COG1971 1173026008120 Domain of unknown function DUF; Region: DUF204; pfam02659 1173026008121 Domain of unknown function DUF; Region: DUF204; pfam02659 1173026008122 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1173026008123 short chain dehydrogenase; Provisional; Region: PRK06914 1173026008124 NADP binding site [chemical binding]; other site 1173026008125 active site 1173026008126 steroid binding site; other site 1173026008127 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173026008128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026008129 Walker A/P-loop; other site 1173026008130 ATP binding site [chemical binding]; other site 1173026008131 Q-loop/lid; other site 1173026008132 ABC transporter signature motif; other site 1173026008133 Walker B; other site 1173026008134 D-loop; other site 1173026008135 H-loop/switch region; other site 1173026008136 DevC protein; Region: devC; TIGR01185 1173026008137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026008138 FtsX-like permease family; Region: FtsX; pfam02687 1173026008139 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173026008140 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026008141 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1173026008142 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026008143 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173026008144 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173026008145 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1173026008146 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173026008147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026008148 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1173026008149 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173026008150 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173026008151 Walker A/P-loop; other site 1173026008152 ATP binding site [chemical binding]; other site 1173026008153 Q-loop/lid; other site 1173026008154 ABC transporter signature motif; other site 1173026008155 Walker B; other site 1173026008156 D-loop; other site 1173026008157 H-loop/switch region; other site 1173026008158 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1173026008159 putative carbohydrate binding site [chemical binding]; other site 1173026008160 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1173026008161 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1173026008162 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1173026008163 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026008164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008165 active site 1173026008166 phosphorylation site [posttranslational modification] 1173026008167 intermolecular recognition site; other site 1173026008168 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026008169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008170 putative active site [active] 1173026008171 heme pocket [chemical binding]; other site 1173026008172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008173 dimer interface [polypeptide binding]; other site 1173026008174 phosphorylation site [posttranslational modification] 1173026008175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008176 ATP binding site [chemical binding]; other site 1173026008177 Mg2+ binding site [ion binding]; other site 1173026008178 G-X-G motif; other site 1173026008179 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008181 active site 1173026008182 phosphorylation site [posttranslational modification] 1173026008183 intermolecular recognition site; other site 1173026008184 dimerization interface [polypeptide binding]; other site 1173026008185 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008187 active site 1173026008188 phosphorylation site [posttranslational modification] 1173026008189 intermolecular recognition site; other site 1173026008190 dimerization interface [polypeptide binding]; other site 1173026008191 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008193 active site 1173026008194 phosphorylation site [posttranslational modification] 1173026008195 intermolecular recognition site; other site 1173026008196 dimerization interface [polypeptide binding]; other site 1173026008197 PAS domain S-box; Region: sensory_box; TIGR00229 1173026008198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008199 putative active site [active] 1173026008200 heme pocket [chemical binding]; other site 1173026008201 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026008202 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026008203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008204 dimer interface [polypeptide binding]; other site 1173026008205 phosphorylation site [posttranslational modification] 1173026008206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008207 ATP binding site [chemical binding]; other site 1173026008208 Mg2+ binding site [ion binding]; other site 1173026008209 G-X-G motif; other site 1173026008210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026008211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008212 dimer interface [polypeptide binding]; other site 1173026008213 phosphorylation site [posttranslational modification] 1173026008214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008215 ATP binding site [chemical binding]; other site 1173026008216 Mg2+ binding site [ion binding]; other site 1173026008217 G-X-G motif; other site 1173026008218 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008219 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008221 active site 1173026008222 phosphorylation site [posttranslational modification] 1173026008223 intermolecular recognition site; other site 1173026008224 dimerization interface [polypeptide binding]; other site 1173026008225 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026008226 putative binding surface; other site 1173026008227 active site 1173026008228 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026008229 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1173026008230 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173026008231 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026008232 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026008233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026008234 Walker A motif; other site 1173026008235 ATP binding site [chemical binding]; other site 1173026008236 Walker B motif; other site 1173026008237 arginine finger; other site 1173026008238 UvrB/uvrC motif; Region: UVR; pfam02151 1173026008239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026008240 Walker A motif; other site 1173026008241 ATP binding site [chemical binding]; other site 1173026008242 Walker B motif; other site 1173026008243 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173026008244 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1173026008245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026008246 Coenzyme A binding pocket [chemical binding]; other site 1173026008247 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1173026008248 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1173026008249 active site 1173026008250 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1173026008251 substrate binding site [chemical binding]; other site 1173026008252 catalytic residues [active] 1173026008253 dimer interface [polypeptide binding]; other site 1173026008254 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1173026008255 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1173026008256 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1173026008257 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1173026008258 catalytic residue [active] 1173026008259 putative FPP diphosphate binding site; other site 1173026008260 putative FPP binding hydrophobic cleft; other site 1173026008261 dimer interface [polypeptide binding]; other site 1173026008262 putative IPP diphosphate binding site; other site 1173026008263 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 1173026008264 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026008265 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173026008266 HSP70 interaction site [polypeptide binding]; other site 1173026008267 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173026008268 O-Antigen ligase; Region: Wzy_C; pfam04932 1173026008269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1173026008270 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1173026008271 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1173026008272 5-oxoprolinase; Region: PLN02666 1173026008273 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1173026008274 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1173026008275 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1173026008276 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1173026008277 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1173026008278 NADP-binding site; other site 1173026008279 homotetramer interface [polypeptide binding]; other site 1173026008280 substrate binding site [chemical binding]; other site 1173026008281 homodimer interface [polypeptide binding]; other site 1173026008282 active site 1173026008283 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1173026008284 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1173026008285 NADP binding site [chemical binding]; other site 1173026008286 active site 1173026008287 putative substrate binding site [chemical binding]; other site 1173026008288 MEKHLA domain; Region: MEKHLA; pfam08670 1173026008289 excinuclease ABC subunit B; Provisional; Region: PRK05298 1173026008290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026008291 ATP binding site [chemical binding]; other site 1173026008292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026008293 nucleotide binding region [chemical binding]; other site 1173026008294 ATP-binding site [chemical binding]; other site 1173026008295 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1173026008296 UvrB/uvrC motif; Region: UVR; pfam02151 1173026008297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1173026008298 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1173026008299 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1173026008300 substrate binding site [chemical binding]; other site 1173026008301 hexamer interface [polypeptide binding]; other site 1173026008302 metal binding site [ion binding]; metal-binding site 1173026008303 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173026008304 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1173026008305 active site 1173026008306 catalytic residues [active] 1173026008307 serpin-like protein; Provisional; Region: PHA02660 1173026008308 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 1173026008309 reactive center loop; other site 1173026008310 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1173026008311 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026008312 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026008313 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173026008314 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173026008315 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173026008316 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1173026008317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026008318 dimerization interface [polypeptide binding]; other site 1173026008319 putative DNA binding site [nucleotide binding]; other site 1173026008320 putative Zn2+ binding site [ion binding]; other site 1173026008321 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026008322 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026008323 agmatinase; Region: agmatinase; TIGR01230 1173026008324 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1173026008325 putative active site [active] 1173026008326 Mn binding site [ion binding]; other site 1173026008327 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1173026008328 putative nucleotide binding site [chemical binding]; other site 1173026008329 uridine monophosphate binding site [chemical binding]; other site 1173026008330 homohexameric interface [polypeptide binding]; other site 1173026008331 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1173026008332 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1173026008333 hinge region; other site 1173026008334 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1173026008335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026008336 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1173026008337 active site clefts [active] 1173026008338 zinc binding site [ion binding]; other site 1173026008339 dimer interface [polypeptide binding]; other site 1173026008340 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173026008341 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173026008342 putative active site [active] 1173026008343 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 1173026008344 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173026008345 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173026008346 Walker A motif; other site 1173026008347 ATP binding site [chemical binding]; other site 1173026008348 Walker B motif; other site 1173026008349 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1173026008350 metal binding site 2 [ion binding]; metal-binding site 1173026008351 putative DNA binding helix; other site 1173026008352 metal binding site 1 [ion binding]; metal-binding site 1173026008353 dimer interface [polypeptide binding]; other site 1173026008354 structural Zn2+ binding site [ion binding]; other site 1173026008355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026008356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1173026008357 active site 1173026008358 phosphorylation site [posttranslational modification] 1173026008359 intermolecular recognition site; other site 1173026008360 dimerization interface [polypeptide binding]; other site 1173026008361 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 1173026008362 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1173026008363 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1173026008364 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1173026008365 PAS fold; Region: PAS; pfam00989 1173026008366 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026008367 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026008368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008369 putative active site [active] 1173026008370 PAS fold; Region: PAS_3; pfam08447 1173026008371 heme pocket [chemical binding]; other site 1173026008372 PAS fold; Region: PAS_4; pfam08448 1173026008373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008374 putative active site [active] 1173026008375 heme pocket [chemical binding]; other site 1173026008376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008377 putative active site [active] 1173026008378 PAS fold; Region: PAS_3; pfam08447 1173026008379 heme pocket [chemical binding]; other site 1173026008380 PAS domain S-box; Region: sensory_box; TIGR00229 1173026008381 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026008382 GAF domain; Region: GAF; pfam01590 1173026008383 PAS domain S-box; Region: sensory_box; TIGR00229 1173026008384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026008385 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026008386 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026008387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008388 dimer interface [polypeptide binding]; other site 1173026008389 phosphorylation site [posttranslational modification] 1173026008390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008391 ATP binding site [chemical binding]; other site 1173026008392 Mg2+ binding site [ion binding]; other site 1173026008393 G-X-G motif; other site 1173026008394 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008396 active site 1173026008397 phosphorylation site [posttranslational modification] 1173026008398 intermolecular recognition site; other site 1173026008399 dimerization interface [polypeptide binding]; other site 1173026008400 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026008401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008402 dimer interface [polypeptide binding]; other site 1173026008403 phosphorylation site [posttranslational modification] 1173026008404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008405 ATP binding site [chemical binding]; other site 1173026008406 Mg2+ binding site [ion binding]; other site 1173026008407 G-X-G motif; other site 1173026008408 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026008409 GAF domain; Region: GAF_3; pfam13492 1173026008410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026008411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008412 dimer interface [polypeptide binding]; other site 1173026008413 phosphorylation site [posttranslational modification] 1173026008414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008415 ATP binding site [chemical binding]; other site 1173026008416 Mg2+ binding site [ion binding]; other site 1173026008417 G-X-G motif; other site 1173026008418 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008420 active site 1173026008421 phosphorylation site [posttranslational modification] 1173026008422 intermolecular recognition site; other site 1173026008423 dimerization interface [polypeptide binding]; other site 1173026008424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026008425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008426 dimer interface [polypeptide binding]; other site 1173026008427 phosphorylation site [posttranslational modification] 1173026008428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008429 ATP binding site [chemical binding]; other site 1173026008430 Mg2+ binding site [ion binding]; other site 1173026008431 G-X-G motif; other site 1173026008432 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008433 PAS domain; Region: PAS_9; pfam13426 1173026008434 putative active site [active] 1173026008435 heme pocket [chemical binding]; other site 1173026008436 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026008437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008438 active site 1173026008439 phosphorylation site [posttranslational modification] 1173026008440 intermolecular recognition site; other site 1173026008441 dimerization interface [polypeptide binding]; other site 1173026008442 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1173026008443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026008444 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026008445 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1173026008446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026008448 homodimer interface [polypeptide binding]; other site 1173026008449 catalytic residue [active] 1173026008450 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1173026008451 IHF dimer interface [polypeptide binding]; other site 1173026008452 IHF - DNA interface [nucleotide binding]; other site 1173026008453 AMIN domain; Region: AMIN; pfam11741 1173026008454 Secretin and TonB N terminus short domain; Region: STN; pfam07660 1173026008455 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 1173026008456 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1173026008457 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1173026008458 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1173026008459 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1173026008460 Cell division protein FtsA; Region: FtsA; cl17206 1173026008461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1173026008462 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173026008463 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173026008464 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1173026008465 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1173026008466 dimer interface [polypeptide binding]; other site 1173026008467 ssDNA binding site [nucleotide binding]; other site 1173026008468 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173026008469 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173026008470 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1173026008471 active site 1173026008472 Substrate binding site; other site 1173026008473 Mg++ binding site; other site 1173026008474 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173026008475 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173026008476 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 1173026008477 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1173026008478 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1173026008479 YciI-like protein; Reviewed; Region: PRK12864 1173026008480 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1173026008481 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1173026008482 putative tRNA-binding site [nucleotide binding]; other site 1173026008483 B3/4 domain; Region: B3_4; pfam03483 1173026008484 tRNA synthetase B5 domain; Region: B5; smart00874 1173026008485 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1173026008486 dimer interface [polypeptide binding]; other site 1173026008487 motif 1; other site 1173026008488 motif 3; other site 1173026008489 motif 2; other site 1173026008490 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1173026008491 Prominin; Region: Prominin; pfam05478 1173026008492 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173026008493 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026008494 active site 1173026008495 ATP binding site [chemical binding]; other site 1173026008496 substrate binding site [chemical binding]; other site 1173026008497 activation loop (A-loop); other site 1173026008498 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026008499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026008500 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026008501 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1173026008502 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1173026008503 dimer interface [polypeptide binding]; other site 1173026008504 putative functional site; other site 1173026008505 putative MPT binding site; other site 1173026008506 RDD family; Region: RDD; pfam06271 1173026008507 ribosomal protein L33; Region: rpl33; CHL00104 1173026008508 ribosomal protein S18; Region: rps18; CHL00077 1173026008509 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173026008510 RNB domain; Region: RNB; pfam00773 1173026008511 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1173026008512 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1173026008513 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1173026008514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026008515 ATP binding site [chemical binding]; other site 1173026008516 putative Mg++ binding site [ion binding]; other site 1173026008517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026008518 nucleotide binding region [chemical binding]; other site 1173026008519 ATP-binding site [chemical binding]; other site 1173026008520 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1173026008521 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1173026008522 Walker A/P-loop; other site 1173026008523 ATP binding site [chemical binding]; other site 1173026008524 Q-loop/lid; other site 1173026008525 ABC transporter signature motif; other site 1173026008526 Walker B; other site 1173026008527 D-loop; other site 1173026008528 H-loop/switch region; other site 1173026008529 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1173026008530 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026008531 putative active site [active] 1173026008532 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1173026008533 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1173026008534 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1173026008535 homodimer interface [polypeptide binding]; other site 1173026008536 substrate-cofactor binding pocket; other site 1173026008537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026008538 catalytic residue [active] 1173026008539 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1173026008540 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1173026008541 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1173026008542 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1173026008543 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1173026008544 active site 1173026008545 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173026008546 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173026008547 active site 1173026008548 (T/H)XGH motif; other site 1173026008549 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1173026008550 nudix motif; other site 1173026008551 NAD synthetase; Provisional; Region: PRK13981 1173026008552 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1173026008553 multimer interface [polypeptide binding]; other site 1173026008554 active site 1173026008555 catalytic triad [active] 1173026008556 protein interface 1 [polypeptide binding]; other site 1173026008557 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1173026008558 homodimer interface [polypeptide binding]; other site 1173026008559 NAD binding pocket [chemical binding]; other site 1173026008560 ATP binding pocket [chemical binding]; other site 1173026008561 Mg binding site [ion binding]; other site 1173026008562 active-site loop [active] 1173026008563 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026008564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026008565 Walker A/P-loop; other site 1173026008566 ATP binding site [chemical binding]; other site 1173026008567 Q-loop/lid; other site 1173026008568 ABC transporter signature motif; other site 1173026008569 Walker B; other site 1173026008570 D-loop; other site 1173026008571 H-loop/switch region; other site 1173026008572 TPR repeat; Region: TPR_11; pfam13414 1173026008573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026008574 binding surface 1173026008575 TPR motif; other site 1173026008576 TPR repeat; Region: TPR_11; pfam13414 1173026008577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026008578 binding surface 1173026008579 TPR motif; other site 1173026008580 TPR repeat; Region: TPR_11; pfam13414 1173026008581 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1173026008582 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026008583 putative active site [active] 1173026008584 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1173026008585 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1173026008586 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1173026008587 substrate binding pocket [chemical binding]; other site 1173026008588 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1173026008589 B12 binding site [chemical binding]; other site 1173026008590 cobalt ligand [ion binding]; other site 1173026008591 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1173026008592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026008593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026008594 S-adenosylmethionine binding site [chemical binding]; other site 1173026008595 Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069 1173026008596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1173026008597 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1173026008598 Predicted membrane protein [Function unknown]; Region: COG3686 1173026008599 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1173026008600 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173026008601 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173026008602 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1173026008603 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1173026008604 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1173026008605 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026008606 DRTGG domain; Region: DRTGG; pfam07085 1173026008607 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1173026008608 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1173026008609 DXD motif; other site 1173026008610 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 1173026008611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026008612 Walker A motif; other site 1173026008613 ATP binding site [chemical binding]; other site 1173026008614 Walker B motif; other site 1173026008615 arginine finger; other site 1173026008616 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1173026008617 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1173026008618 RNA/DNA hybrid binding site [nucleotide binding]; other site 1173026008619 active site 1173026008620 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173026008621 active site 1173026008622 Predicted membrane protein [Function unknown]; Region: COG2324 1173026008623 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1173026008624 ribosomal protein L21; Region: rpl21; CHL00075 1173026008625 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1173026008626 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1173026008627 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 1173026008628 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1173026008629 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 1173026008630 S-layer homology domain; Region: SLH; pfam00395 1173026008631 S-layer homology domain; Region: SLH; pfam00395 1173026008632 S-layer homology domain; Region: SLH; pfam00395 1173026008633 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1173026008634 homoserine dehydrogenase; Provisional; Region: PRK06349 1173026008635 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1173026008636 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1173026008637 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173026008638 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 1173026008639 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 1173026008640 dimerization interface [polypeptide binding]; other site 1173026008641 FAD binding pocket [chemical binding]; other site 1173026008642 FAD binding motif [chemical binding]; other site 1173026008643 catalytic residues [active] 1173026008644 NAD binding pocket [chemical binding]; other site 1173026008645 phosphate binding motif [ion binding]; other site 1173026008646 beta-alpha-beta structure motif; other site 1173026008647 phosphoribulokinase; Provisional; Region: PRK07429 1173026008648 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173026008649 active site 1173026008650 GxxExxY protein; Region: GxxExxY; TIGR04256 1173026008651 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1173026008652 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173026008653 HIGH motif; other site 1173026008654 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173026008655 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1173026008656 active site 1173026008657 KMSKS motif; other site 1173026008658 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1173026008659 tRNA binding surface [nucleotide binding]; other site 1173026008660 anticodon binding site; other site 1173026008661 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1173026008662 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173026008663 ABC1 family; Region: ABC1; cl17513 1173026008664 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1173026008665 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1173026008666 Walker A/P-loop; other site 1173026008667 ATP binding site [chemical binding]; other site 1173026008668 Q-loop/lid; other site 1173026008669 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1173026008670 ABC transporter signature motif; other site 1173026008671 Walker B; other site 1173026008672 D-loop; other site 1173026008673 H-loop/switch region; other site 1173026008674 Beta-propeller repeat; Region: SBBP; pfam06739 1173026008675 Beta-propeller repeat; Region: SBBP; pfam06739 1173026008676 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173026008677 Predicted membrane protein [Function unknown]; Region: COG2119 1173026008678 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173026008679 Predicted membrane protein [Function unknown]; Region: COG2119 1173026008680 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1173026008681 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1173026008682 Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139 1173026008683 maltose O-acetyltransferase; Provisional; Region: PRK10092 1173026008684 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1173026008685 active site 1173026008686 substrate binding site [chemical binding]; other site 1173026008687 trimer interface [polypeptide binding]; other site 1173026008688 CoA binding site [chemical binding]; other site 1173026008689 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1173026008690 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1173026008691 DHH family; Region: DHH; pfam01368 1173026008692 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026008693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008694 active site 1173026008695 phosphorylation site [posttranslational modification] 1173026008696 intermolecular recognition site; other site 1173026008697 dimerization interface [polypeptide binding]; other site 1173026008698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026008699 PAS fold; Region: PAS_3; pfam08447 1173026008700 putative active site [active] 1173026008701 heme pocket [chemical binding]; other site 1173026008702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026008703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026008704 metal binding site [ion binding]; metal-binding site 1173026008705 active site 1173026008706 I-site; other site 1173026008707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026008708 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1173026008709 Cache domain; Region: Cache_1; pfam02743 1173026008710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1173026008711 dimerization interface [polypeptide binding]; other site 1173026008712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008713 dimer interface [polypeptide binding]; other site 1173026008714 phosphorylation site [posttranslational modification] 1173026008715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008716 ATP binding site [chemical binding]; other site 1173026008717 Mg2+ binding site [ion binding]; other site 1173026008718 G-X-G motif; other site 1173026008719 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026008720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026008721 active site 1173026008722 phosphorylation site [posttranslational modification] 1173026008723 intermolecular recognition site; other site 1173026008724 dimerization interface [polypeptide binding]; other site 1173026008725 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1173026008726 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1173026008727 active site 1173026008728 metal binding site [ion binding]; metal-binding site 1173026008729 DNA binding site [nucleotide binding] 1173026008730 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1173026008731 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173026008732 Active Sites [active] 1173026008733 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1173026008734 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1173026008735 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173026008736 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026008737 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173026008738 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1173026008739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026008740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026008741 dimer interface [polypeptide binding]; other site 1173026008742 phosphorylation site [posttranslational modification] 1173026008743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008744 ATP binding site [chemical binding]; other site 1173026008745 Mg2+ binding site [ion binding]; other site 1173026008746 G-X-G motif; other site 1173026008747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026008748 dimerization interface [polypeptide binding]; other site 1173026008749 putative DNA binding site [nucleotide binding]; other site 1173026008750 putative Zn2+ binding site [ion binding]; other site 1173026008751 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 1173026008752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026008753 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1173026008754 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1173026008755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026008756 catalytic residue [active] 1173026008757 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1173026008758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026008759 Walker A/P-loop; other site 1173026008760 ATP binding site [chemical binding]; other site 1173026008761 Q-loop/lid; other site 1173026008762 ABC transporter signature motif; other site 1173026008763 Walker B; other site 1173026008764 D-loop; other site 1173026008765 H-loop/switch region; other site 1173026008766 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1173026008767 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173026008768 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1173026008769 putative active site [active] 1173026008770 AMIN domain; Region: AMIN; pfam11741 1173026008771 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026008772 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026008773 N-terminal plug; other site 1173026008774 ligand-binding site [chemical binding]; other site 1173026008775 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026008776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026008777 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026008778 putative active site [active] 1173026008779 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1173026008780 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026008781 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026008782 active site 1173026008783 catalytic tetrad [active] 1173026008784 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 1173026008785 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1173026008786 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1173026008787 dimerization interface [polypeptide binding]; other site 1173026008788 active site 1173026008789 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1173026008790 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1173026008791 enolase; Provisional; Region: eno; PRK00077 1173026008792 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1173026008793 dimer interface [polypeptide binding]; other site 1173026008794 metal binding site [ion binding]; metal-binding site 1173026008795 substrate binding pocket [chemical binding]; other site 1173026008796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026008797 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1173026008798 dimer interface [polypeptide binding]; other site 1173026008799 active site 1173026008800 metal binding site [ion binding]; metal-binding site 1173026008801 glutathione binding site [chemical binding]; other site 1173026008802 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173026008803 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1173026008804 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026008805 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026008806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026008807 Walker A motif; other site 1173026008808 ATP binding site [chemical binding]; other site 1173026008809 Walker B motif; other site 1173026008810 arginine finger; other site 1173026008811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026008812 Walker A motif; other site 1173026008813 ATP binding site [chemical binding]; other site 1173026008814 Walker B motif; other site 1173026008815 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173026008816 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1173026008817 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1173026008818 substrate binding site; other site 1173026008819 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1173026008820 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173026008821 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1173026008822 extended (e) SDRs; Region: SDR_e; cd08946 1173026008823 NAD(P) binding site [chemical binding]; other site 1173026008824 active site 1173026008825 substrate binding site [chemical binding]; other site 1173026008826 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1173026008827 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1173026008828 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026008829 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1173026008830 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026008831 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173026008832 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1173026008833 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173026008834 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026008835 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026008836 active site 1173026008837 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173026008838 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173026008839 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1173026008840 active site 1173026008841 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026008842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026008843 active site 1173026008844 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026008845 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026008846 trimer interface [polypeptide binding]; other site 1173026008847 active site 1173026008848 substrate binding site [chemical binding]; other site 1173026008849 CoA binding site [chemical binding]; other site 1173026008850 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1173026008851 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173026008852 heat shock protein 90; Provisional; Region: PRK05218 1173026008853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026008854 ATP binding site [chemical binding]; other site 1173026008855 Mg2+ binding site [ion binding]; other site 1173026008856 G-X-G motif; other site 1173026008857 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1173026008858 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026008859 putative active site [active] 1173026008860 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173026008861 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1173026008862 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1173026008863 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173026008864 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 1173026008865 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173026008866 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1173026008867 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1173026008868 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1173026008869 Virulence factor; Region: Virulence_fact; pfam13769 1173026008870 HEAT repeats; Region: HEAT_2; pfam13646 1173026008871 HEAT repeats; Region: HEAT_2; pfam13646 1173026008872 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173026008873 glycogen branching enzyme; Provisional; Region: PRK05402 1173026008874 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1173026008875 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1173026008876 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1173026008877 active site 1173026008878 catalytic site [active] 1173026008879 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1173026008880 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1173026008881 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1173026008882 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1173026008883 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1173026008884 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1173026008885 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1173026008886 catalytic residues [active] 1173026008887 Clp protease; Region: CLP_protease; pfam00574 1173026008888 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1173026008889 oligomer interface [polypeptide binding]; other site 1173026008890 active site residues [active] 1173026008891 Exoribonuclease R [Transcription]; Region: VacB; COG0557 1173026008892 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1173026008893 RNB domain; Region: RNB; pfam00773 1173026008894 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1173026008895 RNA binding site [nucleotide binding]; other site 1173026008896 aromatic acid decarboxylase; Validated; Region: PRK05920 1173026008897 Flavoprotein; Region: Flavoprotein; pfam02441 1173026008898 shikimate kinase; Reviewed; Region: aroK; PRK00131 1173026008899 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1173026008900 ADP binding site [chemical binding]; other site 1173026008901 magnesium binding site [ion binding]; other site 1173026008902 putative shikimate binding site; other site 1173026008903 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1173026008904 feedback inhibition sensing region; other site 1173026008905 homohexameric interface [polypeptide binding]; other site 1173026008906 nucleotide binding site [chemical binding]; other site 1173026008907 N-acetyl-L-glutamate binding site [chemical binding]; other site 1173026008908 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1173026008909 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1173026008910 generic binding surface II; other site 1173026008911 ssDNA binding site; other site 1173026008912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026008913 ATP binding site [chemical binding]; other site 1173026008914 putative Mg++ binding site [ion binding]; other site 1173026008915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026008916 nucleotide binding region [chemical binding]; other site 1173026008917 ATP-binding site [chemical binding]; other site 1173026008918 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1173026008919 UBA/TS-N domain; Region: UBA; pfam00627 1173026008920 Elongation factor TS; Region: EF_TS; pfam00889 1173026008921 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1173026008922 rRNA interaction site [nucleotide binding]; other site 1173026008923 S8 interaction site; other site 1173026008924 putative laminin-1 binding site; other site 1173026008925 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026008926 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1173026008927 Probable Catalytic site; other site 1173026008928 metal-binding site 1173026008929 argininosuccinate synthase; Provisional; Region: PRK13820 1173026008930 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1173026008931 ANP binding site [chemical binding]; other site 1173026008932 Substrate Binding Site II [chemical binding]; other site 1173026008933 Substrate Binding Site I [chemical binding]; other site 1173026008934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173026008935 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173026008936 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173026008937 anti sigma factor interaction site; other site 1173026008938 regulatory phosphorylation site [posttranslational modification]; other site 1173026008939 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1173026008940 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1173026008941 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1173026008942 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1173026008943 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1173026008944 dimer interface [polypeptide binding]; other site 1173026008945 active site 1173026008946 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1173026008947 folate binding site [chemical binding]; other site 1173026008948 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173026008949 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1173026008950 Mg++ binding site [ion binding]; other site 1173026008951 putative catalytic motif [active] 1173026008952 competence damage-inducible protein A; Provisional; Region: PRK00549 1173026008953 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1173026008954 putative MPT binding site; other site 1173026008955 Competence-damaged protein; Region: CinA; pfam02464 1173026008956 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1173026008957 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1173026008958 trimer interface [polypeptide binding]; other site 1173026008959 active site 1173026008960 dimer interface [polypeptide binding]; other site 1173026008961 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1173026008962 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173026008963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026008964 dimer interface [polypeptide binding]; other site 1173026008965 conserved gate region; other site 1173026008966 putative PBP binding loops; other site 1173026008967 ABC-ATPase subunit interface; other site 1173026008968 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1173026008969 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1173026008970 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173026008971 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026008972 Walker A/P-loop; other site 1173026008973 ATP binding site [chemical binding]; other site 1173026008974 Q-loop/lid; other site 1173026008975 ABC transporter signature motif; other site 1173026008976 Walker B; other site 1173026008977 D-loop; other site 1173026008978 H-loop/switch region; other site 1173026008979 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026008980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026008981 dimer interface [polypeptide binding]; other site 1173026008982 conserved gate region; other site 1173026008983 putative PBP binding loops; other site 1173026008984 ABC-ATPase subunit interface; other site 1173026008985 Protein of unknown function DUF72; Region: DUF72; pfam01904 1173026008986 Predicted membrane protein [Function unknown]; Region: COG4270 1173026008987 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 1173026008988 Hemerythrin-like domain; Region: Hr-like; cd12108 1173026008989 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 1173026008990 catalytic nucleophile [active] 1173026008991 Predicted esterase [General function prediction only]; Region: COG0400 1173026008992 putative hydrolase; Provisional; Region: PRK11460 1173026008993 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173026008994 active site 1173026008995 catalytic triad [active] 1173026008996 oxyanion hole [active] 1173026008997 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026008998 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1173026008999 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1173026009000 HflX GTPase family; Region: HflX; cd01878 1173026009001 G1 box; other site 1173026009002 GTP/Mg2+ binding site [chemical binding]; other site 1173026009003 Switch I region; other site 1173026009004 G2 box; other site 1173026009005 G3 box; other site 1173026009006 Switch II region; other site 1173026009007 G4 box; other site 1173026009008 G5 box; other site 1173026009009 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173026009010 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173026009011 active site 1173026009012 TDP-binding site; other site 1173026009013 acceptor substrate-binding pocket; other site 1173026009014 homodimer interface [polypeptide binding]; other site 1173026009015 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173026009016 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173026009017 putative di-iron ligands [ion binding]; other site 1173026009018 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1173026009019 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1173026009020 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 1173026009021 4Fe-4S binding domain; Region: Fer4; pfam00037 1173026009022 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1173026009023 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1173026009024 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1173026009025 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1173026009026 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1173026009027 active site 1173026009028 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1173026009029 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1173026009030 dimer interface [polypeptide binding]; other site 1173026009031 active site 1173026009032 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1173026009033 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1173026009034 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1173026009035 short chain dehydrogenase; Provisional; Region: PRK07109 1173026009036 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1173026009037 putative NAD(P) binding site [chemical binding]; other site 1173026009038 active site 1173026009039 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1173026009040 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1173026009041 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173026009042 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1173026009043 NAD(P) binding site [chemical binding]; other site 1173026009044 homotetramer interface [polypeptide binding]; other site 1173026009045 homodimer interface [polypeptide binding]; other site 1173026009046 active site 1173026009047 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173026009048 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1173026009049 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026009050 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 1173026009051 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026009052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009053 active site 1173026009054 phosphorylation site [posttranslational modification] 1173026009055 intermolecular recognition site; other site 1173026009056 dimerization interface [polypeptide binding]; other site 1173026009057 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026009058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009059 active site 1173026009060 phosphorylation site [posttranslational modification] 1173026009061 intermolecular recognition site; other site 1173026009062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009063 PAS domain; Region: PAS_9; pfam13426 1173026009064 putative active site [active] 1173026009065 heme pocket [chemical binding]; other site 1173026009066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009067 PAS domain; Region: PAS_9; pfam13426 1173026009068 putative active site [active] 1173026009069 heme pocket [chemical binding]; other site 1173026009070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009071 PAS fold; Region: PAS_3; pfam08447 1173026009072 putative active site [active] 1173026009073 heme pocket [chemical binding]; other site 1173026009074 PAS fold; Region: PAS_4; pfam08448 1173026009075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009076 putative active site [active] 1173026009077 heme pocket [chemical binding]; other site 1173026009078 GAF domain; Region: GAF; pfam01590 1173026009079 GAF domain; Region: GAF_2; pfam13185 1173026009080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026009081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026009082 dimer interface [polypeptide binding]; other site 1173026009083 phosphorylation site [posttranslational modification] 1173026009084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026009085 ATP binding site [chemical binding]; other site 1173026009086 Mg2+ binding site [ion binding]; other site 1173026009087 G-X-G motif; other site 1173026009088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026009089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009090 active site 1173026009091 phosphorylation site [posttranslational modification] 1173026009092 intermolecular recognition site; other site 1173026009093 dimerization interface [polypeptide binding]; other site 1173026009094 PAS domain; Region: PAS_9; pfam13426 1173026009095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009096 putative active site [active] 1173026009097 heme pocket [chemical binding]; other site 1173026009098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026009099 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026009100 putative switch regulator; other site 1173026009101 non-specific DNA interactions [nucleotide binding]; other site 1173026009102 DNA binding site [nucleotide binding] 1173026009103 sequence specific DNA binding site [nucleotide binding]; other site 1173026009104 putative cAMP binding site [chemical binding]; other site 1173026009105 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173026009106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173026009107 Homeodomain-like domain; Region: HTH_23; pfam13384 1173026009108 Winged helix-turn helix; Region: HTH_29; pfam13551 1173026009109 Homeodomain-like domain; Region: HTH_32; pfam13565 1173026009110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009111 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026009112 putative active site [active] 1173026009113 heme pocket [chemical binding]; other site 1173026009114 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026009115 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009116 putative active site [active] 1173026009117 heme pocket [chemical binding]; other site 1173026009118 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026009119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009120 putative active site [active] 1173026009121 heme pocket [chemical binding]; other site 1173026009122 PAS domain; Region: PAS; smart00091 1173026009123 putative active site [active] 1173026009124 heme pocket [chemical binding]; other site 1173026009125 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026009126 putative active site [active] 1173026009127 PAS fold; Region: PAS_3; pfam08447 1173026009128 heme pocket [chemical binding]; other site 1173026009129 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026009130 GAF domain; Region: GAF; pfam01590 1173026009131 GAF domain; Region: GAF; pfam01590 1173026009132 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026009133 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1173026009134 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173026009135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026009136 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1173026009137 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026009138 putative homodimer interface [polypeptide binding]; other site 1173026009139 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1173026009140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026009141 UDP-galactopyranose mutase; Region: GLF; pfam03275 1173026009142 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1173026009143 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1173026009144 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173026009145 NADP binding site [chemical binding]; other site 1173026009146 active site 1173026009147 putative substrate binding site [chemical binding]; other site 1173026009148 Ycf46; Provisional; Region: ycf46; CHL00195 1173026009149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026009150 Walker A motif; other site 1173026009151 ATP binding site [chemical binding]; other site 1173026009152 Walker B motif; other site 1173026009153 arginine finger; other site 1173026009154 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1173026009155 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1173026009156 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1173026009157 G-X-X-G motif; other site 1173026009158 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1173026009159 RxxxH motif; other site 1173026009160 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 1173026009161 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1173026009162 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1173026009163 Bacterial PH domain; Region: DUF304; pfam03703 1173026009164 ribonuclease P; Reviewed; Region: rnpA; PRK03031 1173026009165 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1173026009166 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173026009167 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1173026009168 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1173026009169 ligand binding site [chemical binding]; other site 1173026009170 homodimer interface [polypeptide binding]; other site 1173026009171 NAD(P) binding site [chemical binding]; other site 1173026009172 trimer interface B [polypeptide binding]; other site 1173026009173 trimer interface A [polypeptide binding]; other site 1173026009174 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1173026009175 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1173026009176 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1173026009177 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1173026009178 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1173026009179 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173026009180 putative active site [active] 1173026009181 putative metal binding site [ion binding]; other site 1173026009182 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173026009183 PetN; Region: PetN; pfam03742 1173026009184 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173026009185 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173026009186 NAD(P) binding site [chemical binding]; other site 1173026009187 putative active site [active] 1173026009188 DNA primase large subunit; Validated; Region: PRK02249 1173026009189 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026009190 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173026009191 Walker A/P-loop; other site 1173026009192 ATP binding site [chemical binding]; other site 1173026009193 Q-loop/lid; other site 1173026009194 ABC transporter signature motif; other site 1173026009195 Walker B; other site 1173026009196 D-loop; other site 1173026009197 H-loop/switch region; other site 1173026009198 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1173026009199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173026009200 RNA binding surface [nucleotide binding]; other site 1173026009201 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1173026009202 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1173026009203 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1173026009204 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1173026009205 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1173026009206 replicative DNA helicase; Region: DnaB; TIGR00665 1173026009207 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1173026009208 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1173026009209 Walker A motif; other site 1173026009210 ATP binding site [chemical binding]; other site 1173026009211 Walker B motif; other site 1173026009212 DNA binding loops [nucleotide binding] 1173026009213 Ferritin-like domain; Region: Ferritin; pfam00210 1173026009214 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173026009215 dinuclear metal binding motif [ion binding]; other site 1173026009216 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1173026009217 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1173026009218 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1173026009219 catalytic site [active] 1173026009220 putative active site [active] 1173026009221 putative substrate binding site [chemical binding]; other site 1173026009222 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173026009223 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173026009224 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173026009225 S-layer homology domain; Region: SLH; pfam00395 1173026009226 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026009227 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026009228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026009229 putative switch regulator; other site 1173026009230 non-specific DNA interactions [nucleotide binding]; other site 1173026009231 DNA binding site [nucleotide binding] 1173026009232 sequence specific DNA binding site [nucleotide binding]; other site 1173026009233 putative cAMP binding site [chemical binding]; other site 1173026009234 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1173026009235 PhoU domain; Region: PhoU; pfam01895 1173026009236 PhoU domain; Region: PhoU; pfam01895 1173026009237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026009238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026009239 dimer interface [polypeptide binding]; other site 1173026009240 phosphorylation site [posttranslational modification] 1173026009241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026009242 ATP binding site [chemical binding]; other site 1173026009243 Mg2+ binding site [ion binding]; other site 1173026009244 G-X-G motif; other site 1173026009245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026009246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009247 active site 1173026009248 phosphorylation site [posttranslational modification] 1173026009249 intermolecular recognition site; other site 1173026009250 dimerization interface [polypeptide binding]; other site 1173026009251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026009252 DNA binding site [nucleotide binding] 1173026009253 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1173026009254 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1173026009255 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1173026009256 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1173026009257 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1173026009258 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026009259 active site 1173026009260 metal binding site [ion binding]; metal-binding site 1173026009261 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026009262 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026009263 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026009264 putative switch regulator; other site 1173026009265 non-specific DNA interactions [nucleotide binding]; other site 1173026009266 DNA binding site [nucleotide binding] 1173026009267 sequence specific DNA binding site [nucleotide binding]; other site 1173026009268 putative cAMP binding site [chemical binding]; other site 1173026009269 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1173026009270 dimer interface [polypeptide binding]; other site 1173026009271 active site 1173026009272 aspartate-rich active site metal binding site; other site 1173026009273 allosteric magnesium binding site [ion binding]; other site 1173026009274 Schiff base residues; other site 1173026009275 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1173026009276 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1173026009277 Predicted membrane protein [Function unknown]; Region: COG4270 1173026009278 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1173026009279 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026009280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026009281 S-adenosylmethionine binding site [chemical binding]; other site 1173026009282 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173026009283 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1173026009284 substrate binding site [chemical binding]; other site 1173026009285 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 1173026009286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026009287 dimer interface [polypeptide binding]; other site 1173026009288 conserved gate region; other site 1173026009289 putative PBP binding loops; other site 1173026009290 ABC-ATPase subunit interface; other site 1173026009291 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1173026009292 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1173026009293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026009294 dimer interface [polypeptide binding]; other site 1173026009295 conserved gate region; other site 1173026009296 putative PBP binding loops; other site 1173026009297 ABC-ATPase subunit interface; other site 1173026009298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026009299 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1173026009300 Walker A/P-loop; other site 1173026009301 ATP binding site [chemical binding]; other site 1173026009302 Q-loop/lid; other site 1173026009303 ABC transporter signature motif; other site 1173026009304 Walker B; other site 1173026009305 D-loop; other site 1173026009306 H-loop/switch region; other site 1173026009307 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173026009308 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1173026009309 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026009310 Walker A/P-loop; other site 1173026009311 ATP binding site [chemical binding]; other site 1173026009312 Q-loop/lid; other site 1173026009313 ABC transporter signature motif; other site 1173026009314 Walker B; other site 1173026009315 D-loop; other site 1173026009316 H-loop/switch region; other site 1173026009317 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009318 FG-GAP repeat; Region: FG-GAP; cl15299 1173026009319 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009320 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009321 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009322 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009323 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009324 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026009325 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026009326 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026009327 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026009328 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026009329 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026009330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026009331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026009332 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1173026009333 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1173026009334 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1173026009335 active site 1173026009336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173026009337 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1173026009338 NADP binding site [chemical binding]; other site 1173026009339 substrate binding site [chemical binding]; other site 1173026009340 active site 1173026009341 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1173026009342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026009343 non-specific DNA binding site [nucleotide binding]; other site 1173026009344 salt bridge; other site 1173026009345 sequence-specific DNA binding site [nucleotide binding]; other site 1173026009346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026009347 binding surface 1173026009348 TPR motif; other site 1173026009349 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026009350 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026009351 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026009352 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026009353 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026009354 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1173026009355 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1173026009356 catalytic triad [active] 1173026009357 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1173026009358 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1173026009359 Helix-turn-helix domain; Region: HTH_18; pfam12833 1173026009360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026009361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026009362 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 1173026009363 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026009364 putative active site [active] 1173026009365 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1173026009366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173026009367 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1173026009368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026009369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026009370 dimer interface [polypeptide binding]; other site 1173026009371 phosphorylation site [posttranslational modification] 1173026009372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026009373 ATP binding site [chemical binding]; other site 1173026009374 Mg2+ binding site [ion binding]; other site 1173026009375 G-X-G motif; other site 1173026009376 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026009377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009378 active site 1173026009379 phosphorylation site [posttranslational modification] 1173026009380 intermolecular recognition site; other site 1173026009381 dimerization interface [polypeptide binding]; other site 1173026009382 multidrug efflux protein; Reviewed; Region: PRK01766 1173026009383 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173026009384 cation binding site [ion binding]; other site 1173026009385 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1173026009386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026009387 DNA-binding site [nucleotide binding]; DNA binding site 1173026009388 FCD domain; Region: FCD; pfam07729 1173026009389 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1173026009390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026009391 motif II; other site 1173026009392 Predicted transcriptional regulator [Transcription]; Region: COG2378 1173026009393 WYL domain; Region: WYL; pfam13280 1173026009394 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 1173026009395 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1173026009396 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1173026009397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173026009398 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1173026009399 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 1173026009400 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1173026009401 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1173026009402 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1173026009403 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1173026009404 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1173026009405 MOSC domain; Region: MOSC; pfam03473 1173026009406 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1173026009407 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173026009408 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1173026009409 active site 1173026009410 FMN binding site [chemical binding]; other site 1173026009411 substrate binding site [chemical binding]; other site 1173026009412 3Fe-4S cluster binding site [ion binding]; other site 1173026009413 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1173026009414 domain_subunit interface; other site 1173026009415 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1173026009416 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173026009417 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1173026009418 active site 1173026009419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1173026009420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026009421 DNA-binding site [nucleotide binding]; DNA binding site 1173026009422 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1173026009423 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1173026009424 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173026009425 S-layer homology domain; Region: SLH; pfam00395 1173026009426 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1173026009427 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173026009428 Cytochrome P450; Region: p450; pfam00067 1173026009429 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026009430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009431 active site 1173026009432 phosphorylation site [posttranslational modification] 1173026009433 intermolecular recognition site; other site 1173026009434 dimerization interface [polypeptide binding]; other site 1173026009435 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026009436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026009437 dimer interface [polypeptide binding]; other site 1173026009438 phosphorylation site [posttranslational modification] 1173026009439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026009440 ATP binding site [chemical binding]; other site 1173026009441 Mg2+ binding site [ion binding]; other site 1173026009442 G-X-G motif; other site 1173026009443 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026009444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009445 active site 1173026009446 phosphorylation site [posttranslational modification] 1173026009447 intermolecular recognition site; other site 1173026009448 dimerization interface [polypeptide binding]; other site 1173026009449 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1173026009450 GAF domain; Region: GAF; pfam01590 1173026009451 Phytochrome region; Region: PHY; pfam00360 1173026009452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026009453 dimer interface [polypeptide binding]; other site 1173026009454 phosphorylation site [posttranslational modification] 1173026009455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026009456 ATP binding site [chemical binding]; other site 1173026009457 Mg2+ binding site [ion binding]; other site 1173026009458 G-X-G motif; other site 1173026009459 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1173026009460 nucleoside/Zn binding site; other site 1173026009461 dimer interface [polypeptide binding]; other site 1173026009462 catalytic motif [active] 1173026009463 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1173026009464 active site 1173026009465 dimerization interface [polypeptide binding]; other site 1173026009466 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1173026009467 dimer interface [polypeptide binding]; other site 1173026009468 ADP-ribose binding site [chemical binding]; other site 1173026009469 active site 1173026009470 nudix motif; other site 1173026009471 metal binding site [ion binding]; metal-binding site 1173026009472 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1173026009473 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1173026009474 active site 1173026009475 Enolase C-terminal domain-like; Region: MR_MLE_C; pfam13378 1173026009476 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1173026009477 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026009478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1173026009479 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1173026009480 Peptidase family M48; Region: Peptidase_M48; cl12018 1173026009481 Circadian oscillating protein COP23; Region: COP23; pfam14218 1173026009482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173026009483 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1173026009484 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1173026009485 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1173026009486 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1173026009487 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1173026009488 Repair protein; Region: Repair_PSII; pfam04536 1173026009489 Rhomboid family; Region: Rhomboid; pfam01694 1173026009490 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1173026009491 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1173026009492 dimanganese center [ion binding]; other site 1173026009493 Cupin domain; Region: Cupin_2; pfam07883 1173026009494 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1173026009495 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173026009496 NAD binding site [chemical binding]; other site 1173026009497 catalytic Zn binding site [ion binding]; other site 1173026009498 structural Zn binding site [ion binding]; other site 1173026009499 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1173026009500 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1173026009501 NAD binding site [chemical binding]; other site 1173026009502 catalytic Zn binding site [ion binding]; other site 1173026009503 structural Zn binding site [ion binding]; other site 1173026009504 Predicted integral membrane protein [Function unknown]; Region: COG5637 1173026009505 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173026009506 putative hydrophobic ligand binding site [chemical binding]; other site 1173026009507 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1173026009508 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1173026009509 proposed catalytic triad [active] 1173026009510 conserved cys residue [active] 1173026009511 Ferritin-like domain; Region: Ferritin; pfam00210 1173026009512 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1173026009513 dinuclear metal binding motif [ion binding]; other site 1173026009514 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1173026009515 classical (c) SDRs; Region: SDR_c; cd05233 1173026009516 NAD(P) binding site [chemical binding]; other site 1173026009517 active site 1173026009518 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173026009519 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173026009520 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1173026009521 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1173026009522 putative active site [active] 1173026009523 catalytic site [active] 1173026009524 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1173026009525 putative active site [active] 1173026009526 catalytic site [active] 1173026009527 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1173026009528 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 1173026009529 active site 1173026009530 substrate binding site [chemical binding]; other site 1173026009531 metal binding site [ion binding]; metal-binding site 1173026009532 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1173026009533 active site 1173026009534 dimerization interface [polypeptide binding]; other site 1173026009535 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1173026009536 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1173026009537 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1173026009538 dimer interface [polypeptide binding]; other site 1173026009539 substrate binding site [chemical binding]; other site 1173026009540 ATP binding site [chemical binding]; other site 1173026009541 Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513 1173026009542 putative di-iron ligands [ion binding]; other site 1173026009543 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1173026009544 classical (c) SDRs; Region: SDR_c; cd05233 1173026009545 NAD(P) binding site [chemical binding]; other site 1173026009546 active site 1173026009547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026009548 dimerization interface [polypeptide binding]; other site 1173026009549 putative DNA binding site [nucleotide binding]; other site 1173026009550 putative Zn2+ binding site [ion binding]; other site 1173026009551 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173026009552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173026009553 dimer interface [polypeptide binding]; other site 1173026009554 putative PBP binding regions; other site 1173026009555 ABC-ATPase subunit interface; other site 1173026009556 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026009557 active site 1173026009558 catalytic residues [active] 1173026009559 DNA binding site [nucleotide binding] 1173026009560 Int/Topo IB signature motif; other site 1173026009561 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1173026009562 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173026009563 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173026009564 catalytic residues [active] 1173026009565 catalytic nucleophile [active] 1173026009566 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173026009567 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173026009568 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173026009569 Synaptic Site I dimer interface [polypeptide binding]; other site 1173026009570 DNA binding site [nucleotide binding] 1173026009571 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1173026009572 DNA-binding interface [nucleotide binding]; DNA binding site 1173026009573 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1173026009574 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1173026009575 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1173026009576 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026009577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026009578 DNA binding residues [nucleotide binding] 1173026009579 dimerization interface [polypeptide binding]; other site 1173026009580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026009581 DNA binding residues [nucleotide binding] 1173026009582 dimerization interface [polypeptide binding]; other site 1173026009583 chaperone protein DnaJ; Provisional; Region: PRK14284 1173026009584 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1173026009585 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1173026009586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026009587 non-specific DNA binding site [nucleotide binding]; other site 1173026009588 salt bridge; other site 1173026009589 sequence-specific DNA binding site [nucleotide binding]; other site 1173026009590 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026009591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1173026009592 Predicted kinase [General function prediction only]; Region: COG0645 1173026009593 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1173026009594 ATP-binding site [chemical binding]; other site 1173026009595 Gluconate-6-phosphate binding site [chemical binding]; other site 1173026009596 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1173026009597 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1173026009598 5S rRNA interface [nucleotide binding]; other site 1173026009599 CTC domain interface [polypeptide binding]; other site 1173026009600 L16 interface [polypeptide binding]; other site 1173026009601 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1173026009602 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1173026009603 GDP-binding site [chemical binding]; other site 1173026009604 ACT binding site; other site 1173026009605 IMP binding site; other site 1173026009606 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1173026009607 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 1173026009608 active site 1173026009609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026009610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009611 active site 1173026009612 phosphorylation site [posttranslational modification] 1173026009613 intermolecular recognition site; other site 1173026009614 dimerization interface [polypeptide binding]; other site 1173026009615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026009616 DNA binding site [nucleotide binding] 1173026009617 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173026009618 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 1173026009619 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1173026009620 PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041 1173026009621 Ycf39; Provisional; Region: ycf39; CHL00194 1173026009622 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173026009623 NAD(P) binding site [chemical binding]; other site 1173026009624 putative active site [active] 1173026009625 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1173026009626 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 1173026009627 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1173026009628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026009629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009630 active site 1173026009631 phosphorylation site [posttranslational modification] 1173026009632 intermolecular recognition site; other site 1173026009633 dimerization interface [polypeptide binding]; other site 1173026009634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026009635 DNA binding site [nucleotide binding] 1173026009636 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1173026009637 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 1173026009638 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1173026009639 homodimer interface [polypeptide binding]; other site 1173026009640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026009641 catalytic residue [active] 1173026009642 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1173026009643 putative hydrophobic ligand binding site [chemical binding]; other site 1173026009644 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1173026009645 active site 1173026009646 ribulose/triose binding site [chemical binding]; other site 1173026009647 phosphate binding site [ion binding]; other site 1173026009648 substrate (anthranilate) binding pocket [chemical binding]; other site 1173026009649 product (indole) binding pocket [chemical binding]; other site 1173026009650 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1173026009651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026009652 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026009653 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1173026009654 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1173026009655 NAD binding site [chemical binding]; other site 1173026009656 homodimer interface [polypeptide binding]; other site 1173026009657 active site 1173026009658 substrate binding site [chemical binding]; other site 1173026009659 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1173026009660 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1173026009661 tetrameric interface [polypeptide binding]; other site 1173026009662 NAD binding site [chemical binding]; other site 1173026009663 catalytic residues [active] 1173026009664 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1173026009665 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1173026009666 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1173026009667 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1173026009668 active site 1173026009669 dimer interface [polypeptide binding]; other site 1173026009670 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1173026009671 Ligand Binding Site [chemical binding]; other site 1173026009672 Molecular Tunnel; other site 1173026009673 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1173026009674 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026009675 Walker A/P-loop; other site 1173026009676 ATP binding site [chemical binding]; other site 1173026009677 Q-loop/lid; other site 1173026009678 ABC transporter signature motif; other site 1173026009679 Walker B; other site 1173026009680 D-loop; other site 1173026009681 H-loop/switch region; other site 1173026009682 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1173026009683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1173026009684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026009685 Walker A/P-loop; other site 1173026009686 ATP binding site [chemical binding]; other site 1173026009687 Q-loop/lid; other site 1173026009688 ABC transporter signature motif; other site 1173026009689 Walker B; other site 1173026009690 D-loop; other site 1173026009691 H-loop/switch region; other site 1173026009692 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1173026009693 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1173026009694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026009695 dimer interface [polypeptide binding]; other site 1173026009696 conserved gate region; other site 1173026009697 ABC-ATPase subunit interface; other site 1173026009698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1173026009699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026009700 dimer interface [polypeptide binding]; other site 1173026009701 conserved gate region; other site 1173026009702 putative PBP binding loops; other site 1173026009703 ABC-ATPase subunit interface; other site 1173026009704 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1173026009705 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1173026009706 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1173026009707 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1173026009708 Mg++ binding site [ion binding]; other site 1173026009709 putative catalytic motif [active] 1173026009710 substrate binding site [chemical binding]; other site 1173026009711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173026009712 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173026009713 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173026009714 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1173026009715 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1173026009716 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1173026009717 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1173026009718 putative active site [active] 1173026009719 Zn binding site [ion binding]; other site 1173026009720 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1173026009721 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1173026009722 DAK2 domain; Region: Dak2; cl03685 1173026009723 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1173026009724 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173026009725 G1 box; other site 1173026009726 GTP/Mg2+ binding site [chemical binding]; other site 1173026009727 Switch I region; other site 1173026009728 G2 box; other site 1173026009729 Switch II region; other site 1173026009730 G3 box; other site 1173026009731 G4 box; other site 1173026009732 G5 box; other site 1173026009733 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173026009734 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1173026009735 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1173026009736 putative active site [active] 1173026009737 substrate binding site [chemical binding]; other site 1173026009738 putative cosubstrate binding site; other site 1173026009739 catalytic site [active] 1173026009740 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1173026009741 substrate binding site [chemical binding]; other site 1173026009742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1173026009743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1173026009744 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1173026009745 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1173026009746 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1173026009747 dimerization domain swap beta strand [polypeptide binding]; other site 1173026009748 regulatory protein interface [polypeptide binding]; other site 1173026009749 active site 1173026009750 regulatory phosphorylation site [posttranslational modification]; other site 1173026009751 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1173026009752 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1173026009753 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1173026009754 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173026009755 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026009756 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1173026009757 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 1173026009758 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1173026009759 active site 1173026009760 dimer interface [polypeptide binding]; other site 1173026009761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026009762 active site 1173026009763 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1173026009764 classical (c) SDRs; Region: SDR_c; cd05233 1173026009765 NAD(P) binding site [chemical binding]; other site 1173026009766 active site 1173026009767 aspartate aminotransferase; Provisional; Region: PRK05957 1173026009768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026009769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026009770 homodimer interface [polypeptide binding]; other site 1173026009771 catalytic residue [active] 1173026009772 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1173026009773 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1173026009774 glutaminase active site [active] 1173026009775 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1173026009776 dimer interface [polypeptide binding]; other site 1173026009777 active site 1173026009778 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1173026009779 dimer interface [polypeptide binding]; other site 1173026009780 active site 1173026009781 photosystem I subunit VII; Region: psaC; CHL00065 1173026009782 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173026009783 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1173026009784 Domain of unknown function DUF59; Region: DUF59; pfam01883 1173026009785 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1173026009786 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1173026009787 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1173026009788 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1173026009789 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 1173026009790 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1173026009791 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173026009792 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173026009793 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1173026009794 heme binding pocket [chemical binding]; other site 1173026009795 heme ligand [chemical binding]; other site 1173026009796 Cytochrome P450; Region: p450; pfam00067 1173026009797 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173026009798 Domain of unknown function (DUF897); Region: DUF897; pfam05982 1173026009799 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1173026009800 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1173026009801 active site clefts [active] 1173026009802 zinc binding site [ion binding]; other site 1173026009803 dimer interface [polypeptide binding]; other site 1173026009804 hypothetical protein; Provisional; Region: PRK02509 1173026009805 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1173026009806 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1173026009807 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1173026009808 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1173026009809 tRNA; other site 1173026009810 putative tRNA binding site [nucleotide binding]; other site 1173026009811 putative NADP binding site [chemical binding]; other site 1173026009812 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1173026009813 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1173026009814 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1173026009815 putative active site [active] 1173026009816 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1173026009817 GSH binding site [chemical binding]; other site 1173026009818 catalytic residues [active] 1173026009819 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1173026009820 nucleoside/Zn binding site; other site 1173026009821 dimer interface [polypeptide binding]; other site 1173026009822 catalytic motif [active] 1173026009823 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173026009824 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173026009825 putative acyl-acceptor binding pocket; other site 1173026009826 BolA-like protein; Region: BolA; pfam01722 1173026009827 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1173026009828 putative GSH binding site [chemical binding]; other site 1173026009829 catalytic residues [active] 1173026009830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026009831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026009832 active site 1173026009833 phosphorylation site [posttranslational modification] 1173026009834 intermolecular recognition site; other site 1173026009835 dimerization interface [polypeptide binding]; other site 1173026009836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026009837 DNA binding site [nucleotide binding] 1173026009838 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173026009839 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026009840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1173026009841 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1173026009842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026009843 ATP binding site [chemical binding]; other site 1173026009844 putative Mg++ binding site [ion binding]; other site 1173026009845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026009846 nucleotide binding region [chemical binding]; other site 1173026009847 ATP-binding site [chemical binding]; other site 1173026009848 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1173026009849 HRDC domain; Region: HRDC; pfam00570 1173026009850 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1173026009851 AMP-binding enzyme; Region: AMP-binding; pfam00501 1173026009852 acyl-activating enzyme (AAE) consensus motif; other site 1173026009853 putative AMP binding site [chemical binding]; other site 1173026009854 putative active site [active] 1173026009855 putative CoA binding site [chemical binding]; other site 1173026009856 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1173026009857 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1173026009858 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1173026009859 E3 interaction surface; other site 1173026009860 lipoyl attachment site [posttranslational modification]; other site 1173026009861 e3 binding domain; Region: E3_binding; pfam02817 1173026009862 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1173026009863 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1173026009864 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1173026009865 Walker A motif; other site 1173026009866 ATP binding site [chemical binding]; other site 1173026009867 Walker B motif; other site 1173026009868 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1173026009869 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173026009870 putative NAD(P) binding site [chemical binding]; other site 1173026009871 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1173026009872 active site 1173026009873 catalytic motif [active] 1173026009874 Zn binding site [ion binding]; other site 1173026009875 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 1173026009876 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1173026009877 putative valine binding site [chemical binding]; other site 1173026009878 dimer interface [polypeptide binding]; other site 1173026009879 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1173026009880 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1173026009881 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1173026009882 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1173026009883 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1173026009884 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1173026009885 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1173026009886 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173026009887 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173026009888 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173026009889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026009890 Coenzyme A binding pocket [chemical binding]; other site 1173026009891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173026009892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026009893 Coenzyme A binding pocket [chemical binding]; other site 1173026009894 amidase; Provisional; Region: PRK09201 1173026009895 Amidase; Region: Amidase; cl11426 1173026009896 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1173026009897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026009898 putative substrate translocation pore; other site 1173026009899 FRG domain; Region: FRG; pfam08867 1173026009900 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1173026009901 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1173026009902 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 1173026009903 Protein of unknown function (DUF952); Region: DUF952; cl01393 1173026009904 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1173026009905 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1173026009906 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1173026009907 Isochorismatase family; Region: Isochorismatase; pfam00857 1173026009908 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173026009909 catalytic triad [active] 1173026009910 conserved cis-peptide bond; other site 1173026009911 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1173026009912 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1173026009913 active site 1173026009914 putative substrate binding pocket [chemical binding]; other site 1173026009915 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1173026009916 AAA domain; Region: AAA_17; pfam13207 1173026009917 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173026009918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173026009919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026009920 Predicted membrane protein [Function unknown]; Region: COG2259 1173026009921 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1173026009922 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173026009923 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026009924 P-loop; other site 1173026009925 Magnesium ion binding site [ion binding]; other site 1173026009926 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1173026009927 glutaminase A; Region: Gln_ase; TIGR03814 1173026009928 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009929 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009930 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009931 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1173026009932 FG-GAP repeat; Region: FG-GAP; cl15299 1173026009933 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 1173026009934 metal ion-dependent adhesion site (MIDAS); other site 1173026009935 peptide synthase; Provisional; Region: PRK12316 1173026009936 hypothetical protein; Reviewed; Region: PRK00024 1173026009937 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1173026009938 MPN+ (JAMM) motif; other site 1173026009939 Zinc-binding site [ion binding]; other site 1173026009940 phosphoribulokinase; Provisional; Region: PRK07429 1173026009941 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 1173026009942 active site 1173026009943 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 1173026009944 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1173026009945 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1173026009946 homodimer interface [polypeptide binding]; other site 1173026009947 metal binding site [ion binding]; metal-binding site 1173026009948 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1173026009949 homodimer interface [polypeptide binding]; other site 1173026009950 active site 1173026009951 putative chemical substrate binding site [chemical binding]; other site 1173026009952 metal binding site [ion binding]; metal-binding site 1173026009953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 1173026009954 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173026009955 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1173026009956 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1173026009957 putative catalytic cysteine [active] 1173026009958 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1173026009959 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1173026009960 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 1173026009961 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173026009962 O-succinylbenzoate synthase; Provisional; Region: PRK02714 1173026009963 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1173026009964 active site 1173026009965 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1173026009966 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 1173026009967 acyl-activating enzyme (AAE) consensus motif; other site 1173026009968 putative AMP binding site [chemical binding]; other site 1173026009969 putative active site [active] 1173026009970 putative CoA binding site [chemical binding]; other site 1173026009971 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173026009972 active site 1173026009973 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1173026009974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026009975 putative Mg++ binding site [ion binding]; other site 1173026009976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026009977 nucleotide binding region [chemical binding]; other site 1173026009978 ATP-binding site [chemical binding]; other site 1173026009979 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1173026009980 AAA ATPase domain; Region: AAA_16; pfam13191 1173026009981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026009982 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173026009983 Walker A motif; other site 1173026009984 ATP binding site [chemical binding]; other site 1173026009985 Walker B motif; other site 1173026009986 arginine finger; other site 1173026009987 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 1173026009988 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026009989 putative active site [active] 1173026009990 Restriction endonuclease; Region: Mrr_cat; pfam04471 1173026009991 AAA domain; Region: AAA_31; pfam13614 1173026009992 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026009993 P-loop; other site 1173026009994 Magnesium ion binding site [ion binding]; other site 1173026009995 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173026009996 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1173026009997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1173026009998 active site 1173026009999 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1173026010000 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173026010001 mercuric reductase; Validated; Region: PRK06370 1173026010002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026010003 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026010004 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026010005 phosphodiesterase YaeI; Provisional; Region: PRK11340 1173026010006 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173026010007 putative active site [active] 1173026010008 putative metal binding site [ion binding]; other site 1173026010009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1173026010010 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026010011 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1173026010012 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1173026010013 putative active site [active] 1173026010014 catalytic site [active] 1173026010015 putative metal binding site [ion binding]; other site 1173026010016 mce related protein; Region: MCE; pfam02470 1173026010017 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 1173026010018 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1173026010019 amphipathic channel; other site 1173026010020 Asn-Pro-Ala signature motifs; other site 1173026010021 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1173026010022 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1173026010023 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1173026010024 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1173026010025 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173026010026 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173026010027 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026010028 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173026010029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026010030 motif II; other site 1173026010031 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173026010032 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1173026010033 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173026010034 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 1173026010035 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173026010036 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1173026010037 cofactor binding site; other site 1173026010038 DNA binding site [nucleotide binding] 1173026010039 substrate interaction site [chemical binding]; other site 1173026010040 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1173026010041 DNA protecting protein DprA; Region: dprA; TIGR00732 1173026010042 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 1173026010043 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1173026010044 aspartate ammonia-lyase; Provisional; Region: PRK14515 1173026010045 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1173026010046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026010047 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1173026010048 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026010049 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1173026010050 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026010051 Walker A/P-loop; other site 1173026010052 ATP binding site [chemical binding]; other site 1173026010053 Q-loop/lid; other site 1173026010054 ABC transporter signature motif; other site 1173026010055 Walker B; other site 1173026010056 D-loop; other site 1173026010057 H-loop/switch region; other site 1173026010058 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1173026010059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1173026010060 Walker A/P-loop; other site 1173026010061 ATP binding site [chemical binding]; other site 1173026010062 Q-loop/lid; other site 1173026010063 ABC transporter signature motif; other site 1173026010064 Walker B; other site 1173026010065 D-loop; other site 1173026010066 H-loop/switch region; other site 1173026010067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1173026010068 rod shape-determining protein MreB; Provisional; Region: PRK13927 1173026010069 MreB and similar proteins; Region: MreB_like; cd10225 1173026010070 nucleotide binding site [chemical binding]; other site 1173026010071 Mg binding site [ion binding]; other site 1173026010072 putative protofilament interaction site [polypeptide binding]; other site 1173026010073 RodZ interaction site [polypeptide binding]; other site 1173026010074 rod shape-determining protein MreC; Provisional; Region: PRK13922 1173026010075 rod shape-determining protein MreC; Region: MreC; pfam04085 1173026010076 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 1173026010077 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1173026010078 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1173026010079 catalytic motif [active] 1173026010080 Zn binding site [ion binding]; other site 1173026010081 RibD C-terminal domain; Region: RibD_C; cl17279 1173026010082 TPR repeat; Region: TPR_11; pfam13414 1173026010083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026010084 binding surface 1173026010085 TPR motif; other site 1173026010086 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026010087 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1173026010088 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173026010089 ABC-ATPase subunit interface; other site 1173026010090 dimer interface [polypeptide binding]; other site 1173026010091 putative PBP binding regions; other site 1173026010092 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1173026010093 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1173026010094 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1173026010095 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1173026010096 intersubunit interface [polypeptide binding]; other site 1173026010097 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026010098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026010099 catalytic loop [active] 1173026010100 iron binding site [ion binding]; other site 1173026010101 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1173026010102 putative hydrophobic ligand binding site [chemical binding]; other site 1173026010103 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173026010104 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173026010105 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173026010106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026010107 putative substrate translocation pore; other site 1173026010108 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026010109 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026010110 siderophore binding site; other site 1173026010111 AMIN domain; Region: AMIN; pfam11741 1173026010112 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026010113 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026010114 N-terminal plug; other site 1173026010115 ligand-binding site [chemical binding]; other site 1173026010116 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026010117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026010118 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026010119 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026010120 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026010121 AAA ATPase domain; Region: AAA_16; pfam13191 1173026010122 NACHT domain; Region: NACHT; pfam05729 1173026010123 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026010124 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1173026010125 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173026010126 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1173026010127 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1173026010128 conserved cys residue [active] 1173026010129 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1173026010130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026010131 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173026010132 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173026010133 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026010134 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1173026010135 NAD binding site [chemical binding]; other site 1173026010136 putative substrate binding site 2 [chemical binding]; other site 1173026010137 putative substrate binding site 1 [chemical binding]; other site 1173026010138 active site 1173026010139 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173026010140 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173026010141 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173026010142 Ligand Binding Site [chemical binding]; other site 1173026010143 HAS barrel domain; Region: HAS-barrel; pfam09378 1173026010144 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 1173026010145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026010146 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173026010147 catalytic site [active] 1173026010148 S-layer homology domain; Region: SLH; pfam00395 1173026010149 S-layer homology domain; Region: SLH; pfam00395 1173026010150 S-layer homology domain; Region: SLH; pfam00395 1173026010151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026010152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026010153 dimer interface [polypeptide binding]; other site 1173026010154 phosphorylation site [posttranslational modification] 1173026010155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026010156 ATP binding site [chemical binding]; other site 1173026010157 Mg2+ binding site [ion binding]; other site 1173026010158 G-X-G motif; other site 1173026010159 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 1173026010160 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 1173026010161 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173026010162 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173026010163 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 1173026010164 seryl-tRNA synthetase; Provisional; Region: PRK05431 1173026010165 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1173026010166 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1173026010167 dimer interface [polypeptide binding]; other site 1173026010168 active site 1173026010169 motif 1; other site 1173026010170 motif 2; other site 1173026010171 motif 3; other site 1173026010172 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1173026010173 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1173026010174 active site 1173026010175 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1173026010176 protein binding site [polypeptide binding]; other site 1173026010177 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1173026010178 putative substrate binding region [chemical binding]; other site 1173026010179 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1173026010180 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173026010181 minor groove reading motif; other site 1173026010182 helix-hairpin-helix signature motif; other site 1173026010183 substrate binding pocket [chemical binding]; other site 1173026010184 active site 1173026010185 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1173026010186 EamA-like transporter family; Region: EamA; pfam00892 1173026010187 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173026010188 EamA-like transporter family; Region: EamA; pfam00892 1173026010189 ribosomal protein S14; Region: rps14; CHL00074 1173026010190 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1173026010191 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1173026010192 active site 1173026010193 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 1173026010194 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173026010195 active site 1173026010196 catalytic residues [active] 1173026010197 metal binding site [ion binding]; metal-binding site 1173026010198 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173026010199 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173026010200 phosphopeptide binding site; other site 1173026010201 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1173026010202 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173026010203 Double zinc ribbon; Region: DZR; pfam12773 1173026010204 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1173026010205 Protein phosphatase 2C; Region: PP2C; pfam00481 1173026010206 active site 1173026010207 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 1173026010208 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1173026010209 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1173026010210 substrate binding site [chemical binding]; other site 1173026010211 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 1173026010212 putative hydrophobic ligand binding site [chemical binding]; other site 1173026010213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010214 GAF domain; Region: GAF; pfam01590 1173026010215 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010216 GAF domain; Region: GAF; pfam01590 1173026010217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026010218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026010219 dimer interface [polypeptide binding]; other site 1173026010220 phosphorylation site [posttranslational modification] 1173026010221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026010222 ATP binding site [chemical binding]; other site 1173026010223 Mg2+ binding site [ion binding]; other site 1173026010224 G-X-G motif; other site 1173026010225 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1173026010226 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1173026010227 active site 1173026010228 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1173026010229 hypothetical protein; Reviewed; Region: PRK09588 1173026010230 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1173026010231 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173026010232 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1173026010233 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173026010234 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 1173026010235 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173026010236 YcfA-like protein; Region: YcfA; pfam07927 1173026010237 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1173026010238 Lipase (class 2); Region: Lipase_2; pfam01674 1173026010239 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026010240 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173026010241 Walker A/P-loop; other site 1173026010242 ATP binding site [chemical binding]; other site 1173026010243 Q-loop/lid; other site 1173026010244 ABC transporter signature motif; other site 1173026010245 Walker B; other site 1173026010246 D-loop; other site 1173026010247 H-loop/switch region; other site 1173026010248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 1173026010249 conserved hypothetical protein; Region: TIGR03492 1173026010250 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1173026010251 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173026010252 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1173026010253 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173026010254 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1173026010255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026010256 active site 1173026010257 ATP binding site [chemical binding]; other site 1173026010258 substrate binding site [chemical binding]; other site 1173026010259 activation loop (A-loop); other site 1173026010260 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 1173026010261 Predicted permease [General function prediction only]; Region: COG3329 1173026010262 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1173026010263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026010264 putative DNA binding site [nucleotide binding]; other site 1173026010265 putative Zn2+ binding site [ion binding]; other site 1173026010266 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026010267 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173026010268 Walker A/P-loop; other site 1173026010269 ATP binding site [chemical binding]; other site 1173026010270 Q-loop/lid; other site 1173026010271 ABC transporter signature motif; other site 1173026010272 Walker B; other site 1173026010273 D-loop; other site 1173026010274 H-loop/switch region; other site 1173026010275 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026010276 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 1173026010277 Walker A/P-loop; other site 1173026010278 ATP binding site [chemical binding]; other site 1173026010279 Q-loop/lid; other site 1173026010280 ABC transporter signature motif; other site 1173026010281 Walker B; other site 1173026010282 D-loop; other site 1173026010283 H-loop/switch region; other site 1173026010284 NMT1-like family; Region: NMT1_2; pfam13379 1173026010285 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173026010286 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026010287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026010288 dimer interface [polypeptide binding]; other site 1173026010289 conserved gate region; other site 1173026010290 ABC-ATPase subunit interface; other site 1173026010291 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173026010292 NMT1-like family; Region: NMT1_2; pfam13379 1173026010293 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173026010294 Fasciclin domain; Region: Fasciclin; pfam02469 1173026010295 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026010296 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026010297 putative active site [active] 1173026010298 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1173026010299 putative active site [active] 1173026010300 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 1173026010301 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 1173026010302 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026010303 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 1173026010304 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026010305 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1173026010306 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173026010307 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 1173026010308 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173026010309 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1173026010310 lipoyl synthase; Provisional; Region: PRK05481 1173026010311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026010312 FeS/SAM binding site; other site 1173026010313 MarR family; Region: MarR_2; cl17246 1173026010314 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1173026010315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026010316 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173026010317 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1173026010318 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1173026010319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026010320 active site 1173026010321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026010322 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173026010323 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173026010324 putative acyl-acceptor binding pocket; other site 1173026010325 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1173026010326 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1173026010327 active site 1173026010328 HIGH motif; other site 1173026010329 KMSKS motif; other site 1173026010330 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1173026010331 anticodon binding site; other site 1173026010332 tRNA binding surface [nucleotide binding]; other site 1173026010333 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1173026010334 LabA_like proteins; Region: LabA; cd10911 1173026010335 putative metal binding site [ion binding]; other site 1173026010336 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173026010337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1173026010338 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1173026010339 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1173026010340 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1173026010341 putative phosphate acyltransferase; Provisional; Region: PRK05331 1173026010342 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1173026010343 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1173026010344 dimer interface [polypeptide binding]; other site 1173026010345 active site 1173026010346 CoA binding pocket [chemical binding]; other site 1173026010347 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1173026010348 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173026010349 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1173026010350 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1173026010351 putative acyl-acceptor binding pocket; other site 1173026010352 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026010353 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026010354 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1173026010355 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173026010356 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173026010357 putative active site [active] 1173026010358 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 1173026010359 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026010360 HSP70 interaction site [polypeptide binding]; other site 1173026010361 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 1173026010362 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026010363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026010364 active site 1173026010365 phosphorylation site [posttranslational modification] 1173026010366 intermolecular recognition site; other site 1173026010367 dimerization interface [polypeptide binding]; other site 1173026010368 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026010369 DNA binding site [nucleotide binding] 1173026010370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026010371 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026010372 dimer interface [polypeptide binding]; other site 1173026010373 phosphorylation site [posttranslational modification] 1173026010374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026010375 ATP binding site [chemical binding]; other site 1173026010376 Mg2+ binding site [ion binding]; other site 1173026010377 G-X-G motif; other site 1173026010378 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1173026010379 MgtE intracellular N domain; Region: MgtE_N; smart00924 1173026010380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1173026010381 Divalent cation transporter; Region: MgtE; pfam01769 1173026010382 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1173026010383 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1173026010384 C-terminal domain interface [polypeptide binding]; other site 1173026010385 active site 1173026010386 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1173026010387 active site 1173026010388 N-terminal domain interface [polypeptide binding]; other site 1173026010389 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026010390 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1173026010391 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026010392 putative switch regulator; other site 1173026010393 non-specific DNA interactions [nucleotide binding]; other site 1173026010394 DNA binding site [nucleotide binding] 1173026010395 sequence specific DNA binding site [nucleotide binding]; other site 1173026010396 putative cAMP binding site [chemical binding]; other site 1173026010397 Predicted flavoprotein [General function prediction only]; Region: COG0431 1173026010398 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026010399 cell division protein; Validated; Region: ftsH; CHL00176 1173026010400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026010401 Walker A motif; other site 1173026010402 ATP binding site [chemical binding]; other site 1173026010403 Walker B motif; other site 1173026010404 arginine finger; other site 1173026010405 Peptidase family M41; Region: Peptidase_M41; pfam01434 1173026010406 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173026010407 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173026010408 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1173026010409 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1173026010410 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1173026010411 hinge; other site 1173026010412 active site 1173026010413 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1173026010414 PLD-like domain; Region: PLDc_2; pfam13091 1173026010415 putative active site [active] 1173026010416 catalytic site [active] 1173026010417 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173026010418 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026010419 ATP binding site [chemical binding]; other site 1173026010420 putative Mg++ binding site [ion binding]; other site 1173026010421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026010422 nucleotide binding region [chemical binding]; other site 1173026010423 ATP-binding site [chemical binding]; other site 1173026010424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1173026010425 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173026010426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026010427 non-specific DNA binding site [nucleotide binding]; other site 1173026010428 salt bridge; other site 1173026010429 sequence-specific DNA binding site [nucleotide binding]; other site 1173026010430 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1173026010431 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1173026010432 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173026010433 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1173026010434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026010435 dimer interface [polypeptide binding]; other site 1173026010436 conserved gate region; other site 1173026010437 putative PBP binding loops; other site 1173026010438 ABC-ATPase subunit interface; other site 1173026010439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026010440 dimer interface [polypeptide binding]; other site 1173026010441 conserved gate region; other site 1173026010442 putative PBP binding loops; other site 1173026010443 ABC-ATPase subunit interface; other site 1173026010444 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173026010445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026010446 Walker A/P-loop; other site 1173026010447 ATP binding site [chemical binding]; other site 1173026010448 Q-loop/lid; other site 1173026010449 ABC transporter signature motif; other site 1173026010450 Walker B; other site 1173026010451 D-loop; other site 1173026010452 H-loop/switch region; other site 1173026010453 TOBE domain; Region: TOBE_2; pfam08402 1173026010454 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1173026010455 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1173026010456 Walker A/P-loop; other site 1173026010457 ATP binding site [chemical binding]; other site 1173026010458 Q-loop/lid; other site 1173026010459 ABC transporter signature motif; other site 1173026010460 Walker B; other site 1173026010461 D-loop; other site 1173026010462 H-loop/switch region; other site 1173026010463 Caspase domain; Region: Peptidase_C14; pfam00656 1173026010464 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1173026010465 ATP-sulfurylase; Region: ATPS; cd00517 1173026010466 active site 1173026010467 HXXH motif; other site 1173026010468 flexible loop; other site 1173026010469 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1173026010470 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1173026010471 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1173026010472 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1173026010473 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1173026010474 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1173026010475 protein binding site [polypeptide binding]; other site 1173026010476 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1173026010477 AAA ATPase domain; Region: AAA_16; pfam13191 1173026010478 NACHT domain; Region: NACHT; pfam05729 1173026010479 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026010480 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026010481 structural tetrad; other site 1173026010482 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026010483 structural tetrad; other site 1173026010484 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026010485 WD40 repeats; Region: WD40; smart00320 1173026010486 PAS fold; Region: PAS_7; pfam12860 1173026010487 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010488 GAF domain; Region: GAF; cl17456 1173026010489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026010490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026010491 dimer interface [polypeptide binding]; other site 1173026010492 phosphorylation site [posttranslational modification] 1173026010493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026010494 ATP binding site [chemical binding]; other site 1173026010495 Mg2+ binding site [ion binding]; other site 1173026010496 G-X-G motif; other site 1173026010497 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026010498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026010499 active site 1173026010500 phosphorylation site [posttranslational modification] 1173026010501 intermolecular recognition site; other site 1173026010502 dimerization interface [polypeptide binding]; other site 1173026010503 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026010504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026010505 metal binding site [ion binding]; metal-binding site 1173026010506 active site 1173026010507 I-site; other site 1173026010508 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026010509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026010510 active site 1173026010511 YGGT family; Region: YGGT; pfam02325 1173026010512 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1173026010513 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1173026010514 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1173026010515 shikimate binding site; other site 1173026010516 NAD(P) binding site [chemical binding]; other site 1173026010517 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173026010518 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026010519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026010520 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026010521 active site 1173026010522 catalytic tetrad [active] 1173026010523 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 1173026010524 Haemolytic domain; Region: Haemolytic; pfam01809 1173026010525 hypothetical protein; Provisional; Region: PRK06184 1173026010526 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173026010527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173026010528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026010529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026010530 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026010531 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026010532 active site 1173026010533 ATP binding site [chemical binding]; other site 1173026010534 substrate binding site [chemical binding]; other site 1173026010535 activation loop (A-loop); other site 1173026010536 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026010537 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026010538 structural tetrad; other site 1173026010539 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1173026010540 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1173026010541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026010542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026010543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026010544 Protein of unknown function DUF72; Region: DUF72; pfam01904 1173026010545 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 1173026010546 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173026010547 hypothetical protein; Validated; Region: PRK00110 1173026010548 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173026010549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026010550 dimer interface [polypeptide binding]; other site 1173026010551 conserved gate region; other site 1173026010552 putative PBP binding loops; other site 1173026010553 ABC-ATPase subunit interface; other site 1173026010554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026010555 dimer interface [polypeptide binding]; other site 1173026010556 conserved gate region; other site 1173026010557 putative PBP binding loops; other site 1173026010558 ABC-ATPase subunit interface; other site 1173026010559 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173026010560 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026010561 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026010562 protein binding site [polypeptide binding]; other site 1173026010563 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1173026010564 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026010565 DXD motif; other site 1173026010566 PilZ domain; Region: PilZ; pfam07238 1173026010567 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 1173026010568 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1173026010569 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026010570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026010571 TPR motif; other site 1173026010572 binding surface 1173026010573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026010574 TPR motif; other site 1173026010575 binding surface 1173026010576 TPR repeat; Region: TPR_11; pfam13414 1173026010577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026010578 binding surface 1173026010579 TPR motif; other site 1173026010580 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1173026010581 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1173026010582 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1173026010583 CBD_II domain; Region: CBD_II; smart00637 1173026010584 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 1173026010585 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173026010586 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1173026010587 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173026010588 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1173026010589 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1173026010590 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1173026010591 DNA binding site [nucleotide binding] 1173026010592 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1173026010593 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1173026010594 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1173026010595 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1173026010596 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1173026010597 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1173026010598 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1173026010599 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1173026010600 RPB1 interaction site [polypeptide binding]; other site 1173026010601 RPB10 interaction site [polypeptide binding]; other site 1173026010602 RPB11 interaction site [polypeptide binding]; other site 1173026010603 RPB3 interaction site [polypeptide binding]; other site 1173026010604 RPB12 interaction site [polypeptide binding]; other site 1173026010605 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1173026010606 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1173026010607 active site 1173026010608 ribosomal protein S20; Region: rps20; CHL00102 1173026010609 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1173026010610 histidinol dehydrogenase; Region: hisD; TIGR00069 1173026010611 NAD binding site [chemical binding]; other site 1173026010612 dimerization interface [polypeptide binding]; other site 1173026010613 product binding site; other site 1173026010614 substrate binding site [chemical binding]; other site 1173026010615 zinc binding site [ion binding]; other site 1173026010616 catalytic residues [active] 1173026010617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026010618 Ligand Binding Site [chemical binding]; other site 1173026010619 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173026010620 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1173026010621 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026010622 substrate binding site [chemical binding]; other site 1173026010623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026010624 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026010625 active site 1173026010626 catalytic tetrad [active] 1173026010627 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173026010628 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173026010629 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173026010630 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1173026010631 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173026010632 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173026010633 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026010634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026010635 ligand binding site [chemical binding]; other site 1173026010636 flexible hinge region; other site 1173026010637 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173026010638 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1173026010639 putative active site [active] 1173026010640 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026010641 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173026010642 Walker A/P-loop; other site 1173026010643 ATP binding site [chemical binding]; other site 1173026010644 Q-loop/lid; other site 1173026010645 ABC transporter signature motif; other site 1173026010646 Walker B; other site 1173026010647 D-loop; other site 1173026010648 H-loop/switch region; other site 1173026010649 Homeodomain-like domain; Region: HTH_23; pfam13384 1173026010650 Winged helix-turn helix; Region: HTH_29; pfam13551 1173026010651 Homeodomain-like domain; Region: HTH_32; pfam13565 1173026010652 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1173026010653 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1173026010654 dimerization interface [polypeptide binding]; other site 1173026010655 domain crossover interface; other site 1173026010656 redox-dependent activation switch; other site 1173026010657 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026010658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026010659 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173026010660 Walker A/P-loop; other site 1173026010661 ATP binding site [chemical binding]; other site 1173026010662 Q-loop/lid; other site 1173026010663 ABC transporter signature motif; other site 1173026010664 Walker B; other site 1173026010665 D-loop; other site 1173026010666 H-loop/switch region; other site 1173026010667 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1173026010668 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1173026010669 Ligand binding site; other site 1173026010670 metal-binding site 1173026010671 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1173026010672 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 1173026010673 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1173026010674 short chain dehydrogenase; Provisional; Region: PRK12367 1173026010675 NAD(P) binding site [chemical binding]; other site 1173026010676 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1173026010677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1173026010678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026010679 homodimer interface [polypeptide binding]; other site 1173026010680 catalytic residue [active] 1173026010681 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1173026010682 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1173026010683 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1173026010684 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1173026010685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026010686 catalytic loop [active] 1173026010687 iron binding site [ion binding]; other site 1173026010688 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1173026010689 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 1173026010690 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1173026010691 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1173026010692 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1173026010693 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1173026010694 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1173026010695 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026010696 putative active site [active] 1173026010697 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026010698 putative active site [active] 1173026010699 Cytochrome P450; Region: p450; cl12078 1173026010700 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173026010701 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173026010702 dimerization interface [polypeptide binding]; other site 1173026010703 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1173026010704 isocitrate dehydrogenase; Validated; Region: PRK07362 1173026010705 GUN4-like; Region: GUN4; pfam05419 1173026010706 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010707 GAF domain; Region: GAF; pfam01590 1173026010708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026010709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026010710 dimer interface [polypeptide binding]; other site 1173026010711 phosphorylation site [posttranslational modification] 1173026010712 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 1173026010713 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1173026010714 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1173026010715 SmpB-tmRNA interface; other site 1173026010716 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1173026010717 dimerization interface [polypeptide binding]; other site 1173026010718 putative active cleft [active] 1173026010719 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1173026010720 substrate binding site; other site 1173026010721 dimer interface; other site 1173026010722 thiamine monophosphate kinase; Provisional; Region: PRK05731 1173026010723 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1173026010724 ATP binding site [chemical binding]; other site 1173026010725 dimerization interface [polypeptide binding]; other site 1173026010726 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 1173026010727 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1173026010728 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1173026010729 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1173026010730 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1173026010731 active site 1173026010732 (T/H)XGH motif; other site 1173026010733 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1173026010734 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1173026010735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026010736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1173026010737 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1173026010738 FAD binding domain; Region: FAD_binding_4; pfam01565 1173026010739 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1173026010740 hypothetical protein; Validated; Region: PRK00153 1173026010741 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1173026010742 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1173026010743 active site 1173026010744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026010745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026010746 active site 1173026010747 phosphorylation site [posttranslational modification] 1173026010748 intermolecular recognition site; other site 1173026010749 dimerization interface [polypeptide binding]; other site 1173026010750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026010751 DNA binding residues [nucleotide binding] 1173026010752 dimerization interface [polypeptide binding]; other site 1173026010753 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1173026010754 gamma-beta subunit interface [polypeptide binding]; other site 1173026010755 alpha-beta subunit interface [polypeptide binding]; other site 1173026010756 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1173026010757 alpha-gamma subunit interface [polypeptide binding]; other site 1173026010758 beta-gamma subunit interface [polypeptide binding]; other site 1173026010759 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1173026010760 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173026010761 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173026010762 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173026010763 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1173026010764 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173026010765 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173026010766 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173026010767 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173026010768 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1173026010769 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1173026010770 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1173026010771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026010772 active site 1173026010773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026010774 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1173026010775 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173026010776 anti sigma factor interaction site; other site 1173026010777 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173026010778 regulatory phosphorylation site [posttranslational modification]; other site 1173026010779 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026010780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026010781 active site 1173026010782 phosphorylation site [posttranslational modification] 1173026010783 intermolecular recognition site; other site 1173026010784 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1173026010785 dimerization interface [polypeptide binding]; other site 1173026010786 Monopolin complex subunit LRS4; Region: LRS4; pfam10422 1173026010787 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1173026010788 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1173026010789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010790 GAF domain; Region: GAF; pfam01590 1173026010791 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 1173026010792 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1173026010793 PAS domain S-box; Region: sensory_box; TIGR00229 1173026010794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026010795 putative active site [active] 1173026010796 heme pocket [chemical binding]; other site 1173026010797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010798 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026010799 PAS domain S-box; Region: sensory_box; TIGR00229 1173026010800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026010801 putative active site [active] 1173026010802 heme pocket [chemical binding]; other site 1173026010803 PAS fold; Region: PAS_4; pfam08448 1173026010804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026010805 putative active site [active] 1173026010806 heme pocket [chemical binding]; other site 1173026010807 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026010808 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026010809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026010810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026010811 dimer interface [polypeptide binding]; other site 1173026010812 phosphorylation site [posttranslational modification] 1173026010813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026010814 ATP binding site [chemical binding]; other site 1173026010815 Mg2+ binding site [ion binding]; other site 1173026010816 G-X-G motif; other site 1173026010817 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026010818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026010819 active site 1173026010820 phosphorylation site [posttranslational modification] 1173026010821 intermolecular recognition site; other site 1173026010822 dimerization interface [polypeptide binding]; other site 1173026010823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026010824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026010825 active site 1173026010826 phosphorylation site [posttranslational modification] 1173026010827 intermolecular recognition site; other site 1173026010828 dimerization interface [polypeptide binding]; other site 1173026010829 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026010830 putative binding surface; other site 1173026010831 active site 1173026010832 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1173026010833 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1173026010834 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1173026010835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026010836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026010837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026010838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026010839 Walker A/P-loop; other site 1173026010840 ATP binding site [chemical binding]; other site 1173026010841 Q-loop/lid; other site 1173026010842 ABC transporter signature motif; other site 1173026010843 Walker B; other site 1173026010844 D-loop; other site 1173026010845 H-loop/switch region; other site 1173026010846 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026010847 HSP70 interaction site [polypeptide binding]; other site 1173026010848 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026010849 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026010850 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026010851 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1173026010852 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173026010853 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1173026010854 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1173026010855 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173026010856 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173026010857 putative active site [active] 1173026010858 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026010859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026010860 Walker A/P-loop; other site 1173026010861 ATP binding site [chemical binding]; other site 1173026010862 Q-loop/lid; other site 1173026010863 ABC transporter signature motif; other site 1173026010864 Walker B; other site 1173026010865 D-loop; other site 1173026010866 H-loop/switch region; other site 1173026010867 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1173026010868 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010869 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1173026010870 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010871 Kelch motif; Region: Kelch_1; pfam01344 1173026010872 Kelch motif; Region: Kelch_1; pfam01344 1173026010873 Kelch motif; Region: Kelch_6; pfam13964 1173026010874 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1173026010875 Kelch motif; Region: Kelch_6; pfam13964 1173026010876 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010877 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010878 Kelch domain; Region: Kelch; smart00612 1173026010879 Kelch motif; Region: Kelch_1; pfam01344 1173026010880 Kelch motif; Region: Kelch_6; pfam13964 1173026010881 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 1173026010882 Bacterial Ig-like domain; Region: Big_5; pfam13205 1173026010883 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1173026010884 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 1173026010885 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1173026010886 active site 1173026010887 PHP Thumb interface [polypeptide binding]; other site 1173026010888 metal binding site [ion binding]; metal-binding site 1173026010889 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1173026010890 generic binding surface I; other site 1173026010891 generic binding surface II; other site 1173026010892 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026010893 putative active site [active] 1173026010894 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173026010895 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1173026010896 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173026010897 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1173026010898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026010899 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173026010900 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 1173026010901 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1173026010902 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1173026010903 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173026010904 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 1173026010905 active site 1173026010906 dimerization interface [polypeptide binding]; other site 1173026010907 metal binding site [ion binding]; metal-binding site 1173026010908 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1173026010909 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1173026010910 anti sigma factor interaction site; other site 1173026010911 regulatory phosphorylation site [posttranslational modification]; other site 1173026010912 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1173026010913 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1173026010914 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1173026010915 catalytic site [active] 1173026010916 subunit interface [polypeptide binding]; other site 1173026010917 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 1173026010918 lipoprotein NlpI; Provisional; Region: PRK11189 1173026010919 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1173026010920 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1173026010921 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173026010922 protein I interface; other site 1173026010923 D2 interface; other site 1173026010924 protein T interface; other site 1173026010925 chlorophyll binding site; other site 1173026010926 beta carotene binding site; other site 1173026010927 pheophytin binding site; other site 1173026010928 manganese-stabilizing polypeptide interface; other site 1173026010929 CP43 interface; other site 1173026010930 protein L interface; other site 1173026010931 oxygen evolving complex binding site; other site 1173026010932 bromide binding site; other site 1173026010933 quinone binding site; other site 1173026010934 Fe binding site [ion binding]; other site 1173026010935 core light harvesting interface; other site 1173026010936 cytochrome b559 alpha subunit interface; other site 1173026010937 cytochrome c-550 interface; other site 1173026010938 protein J interface; other site 1173026010939 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1173026010940 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1173026010941 catalytic residue [active] 1173026010942 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1173026010943 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1173026010944 NAD(P) binding site [chemical binding]; other site 1173026010945 putative active site [active] 1173026010946 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 1173026010947 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173026010948 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1173026010949 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173026010950 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173026010951 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173026010952 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1173026010953 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173026010954 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1173026010955 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010956 Kelch domain; Region: Kelch; smart00612 1173026010957 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010958 Kelch motif; Region: Kelch_1; pfam01344 1173026010959 Kelch motif; Region: Kelch_1; pfam01344 1173026010960 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1173026010961 Kelch motif; Region: Kelch_6; pfam13964 1173026010962 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1173026010963 active site 1173026010964 glycine dehydrogenase; Provisional; Region: PRK05367 1173026010965 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173026010966 tetramer interface [polypeptide binding]; other site 1173026010967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026010968 catalytic residue [active] 1173026010969 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1173026010970 tetramer interface [polypeptide binding]; other site 1173026010971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026010972 catalytic residue [active] 1173026010973 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1173026010974 lipoyl attachment site [posttranslational modification]; other site 1173026010975 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1173026010976 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1173026010977 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1173026010978 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1173026010979 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1173026010980 EamA-like transporter family; Region: EamA; pfam00892 1173026010981 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1173026010982 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1173026010983 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389 1173026010984 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 1173026010985 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1173026010986 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1173026010987 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1173026010988 hypothetical protein; Provisional; Region: PRK07377 1173026010989 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 1173026010990 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 1173026010991 putative active site [active] 1173026010992 redox center [active] 1173026010993 Hemerythrin-like domain; Region: Hr-like; cd12108 1173026010994 Fe binding site [ion binding]; other site 1173026010995 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1173026010996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026010997 non-specific DNA binding site [nucleotide binding]; other site 1173026010998 salt bridge; other site 1173026010999 sequence-specific DNA binding site [nucleotide binding]; other site 1173026011000 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026011001 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026011002 PAS domain; Region: PAS_9; pfam13426 1173026011003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011004 putative active site [active] 1173026011005 heme pocket [chemical binding]; other site 1173026011006 PAS fold; Region: PAS_3; pfam08447 1173026011007 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173026011008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011009 PAS domain; Region: PAS_9; pfam13426 1173026011010 putative active site [active] 1173026011011 heme pocket [chemical binding]; other site 1173026011012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011013 PAS fold; Region: PAS_4; pfam08448 1173026011014 putative active site [active] 1173026011015 heme pocket [chemical binding]; other site 1173026011016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026011017 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026011018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011019 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026011020 putative active site [active] 1173026011021 heme pocket [chemical binding]; other site 1173026011022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011023 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026011024 putative active site [active] 1173026011025 heme pocket [chemical binding]; other site 1173026011026 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011027 putative active site [active] 1173026011028 heme pocket [chemical binding]; other site 1173026011029 GAF domain; Region: GAF; pfam01590 1173026011030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026011031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026011032 dimer interface [polypeptide binding]; other site 1173026011033 phosphorylation site [posttranslational modification] 1173026011034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026011035 ATP binding site [chemical binding]; other site 1173026011036 Mg2+ binding site [ion binding]; other site 1173026011037 G-X-G motif; other site 1173026011038 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026011039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011040 active site 1173026011041 phosphorylation site [posttranslational modification] 1173026011042 intermolecular recognition site; other site 1173026011043 dimerization interface [polypeptide binding]; other site 1173026011044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026011045 dimerization interface [polypeptide binding]; other site 1173026011046 putative DNA binding site [nucleotide binding]; other site 1173026011047 putative Zn2+ binding site [ion binding]; other site 1173026011048 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1173026011049 AAA domain; Region: AAA_23; pfam13476 1173026011050 Walker A/P-loop; other site 1173026011051 ATP binding site [chemical binding]; other site 1173026011052 Q-loop/lid; other site 1173026011053 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1173026011054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026011055 ABC transporter signature motif; other site 1173026011056 Walker B; other site 1173026011057 D-loop; other site 1173026011058 H-loop/switch region; other site 1173026011059 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1173026011060 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173026011061 active site residue [active] 1173026011062 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1173026011063 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173026011064 catalytic triad [active] 1173026011065 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1173026011066 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1173026011067 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1173026011068 AAA ATPase domain; Region: AAA_16; pfam13191 1173026011069 NACHT domain; Region: NACHT; pfam05729 1173026011070 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1173026011071 putative glycosyl transferase; Provisional; Region: PRK10307 1173026011072 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173026011073 putative acyl transferase; Provisional; Region: PRK10502 1173026011074 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1173026011075 putative trimer interface [polypeptide binding]; other site 1173026011076 putative active site [active] 1173026011077 putative substrate binding site [chemical binding]; other site 1173026011078 putative CoA binding site [chemical binding]; other site 1173026011079 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011080 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173026011081 putative ADP-binding pocket [chemical binding]; other site 1173026011082 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026011083 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1173026011084 trimer interface [polypeptide binding]; other site 1173026011085 active site 1173026011086 substrate binding site [chemical binding]; other site 1173026011087 CoA binding site [chemical binding]; other site 1173026011088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011089 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173026011090 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011091 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026011092 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026011093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026011094 NAD(P) binding site [chemical binding]; other site 1173026011095 active site 1173026011096 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011097 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026011098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026011099 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026011100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011101 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026011102 putative active site [active] 1173026011103 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026011104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026011105 active site 1173026011106 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1173026011107 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026011108 Chain length determinant protein; Region: Wzz; cl15801 1173026011109 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173026011110 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173026011111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026011112 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026011113 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1173026011114 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 1173026011115 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1173026011116 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1173026011117 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1173026011118 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1173026011119 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1173026011120 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1173026011121 putative trimer interface [polypeptide binding]; other site 1173026011122 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 1173026011123 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1173026011124 putative CoA binding site [chemical binding]; other site 1173026011125 putative trimer interface [polypeptide binding]; other site 1173026011126 putative active site [active] 1173026011127 putative substrate binding site [chemical binding]; other site 1173026011128 putative CoA binding site [chemical binding]; other site 1173026011129 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1173026011130 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173026011131 inhibitor-cofactor binding pocket; inhibition site 1173026011132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026011133 catalytic residue [active] 1173026011134 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1173026011135 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1173026011136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026011137 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026011138 NAD(P) binding site [chemical binding]; other site 1173026011139 active site 1173026011140 hypothetical protein; Provisional; Region: PRK07233 1173026011141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026011142 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173026011143 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173026011144 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1173026011145 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1173026011146 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1173026011147 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1173026011148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026011149 active site 1173026011150 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1173026011151 active site 1173026011152 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1173026011153 homodimer interface [polypeptide binding]; other site 1173026011154 S-layer homology domain; Region: SLH; pfam00395 1173026011155 S-layer homology domain; Region: SLH; pfam00395 1173026011156 S-layer homology domain; Region: SLH; pfam00395 1173026011157 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173026011158 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1173026011159 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1173026011160 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1173026011161 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 1173026011162 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011163 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026011164 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026011165 active site 1173026011166 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011167 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 1173026011168 putative ADP-binding pocket [chemical binding]; other site 1173026011169 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026011170 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173026011171 putative metal binding site; other site 1173026011172 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173026011173 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173026011174 putative active site [active] 1173026011175 putative acyl transferase; Provisional; Region: PRK10502 1173026011176 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1173026011177 putative trimer interface [polypeptide binding]; other site 1173026011178 putative active site [active] 1173026011179 putative substrate binding site [chemical binding]; other site 1173026011180 putative CoA binding site [chemical binding]; other site 1173026011181 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1173026011182 putative glycosyl transferase; Provisional; Region: PRK10307 1173026011183 Chain length determinant protein; Region: Wzz; pfam02706 1173026011184 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026011185 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173026011186 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026011187 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1173026011188 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1173026011189 active site 1173026011190 dimer interface [polypeptide binding]; other site 1173026011191 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1173026011192 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1173026011193 active site 1173026011194 FMN binding site [chemical binding]; other site 1173026011195 substrate binding site [chemical binding]; other site 1173026011196 3Fe-4S cluster binding site [ion binding]; other site 1173026011197 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1173026011198 domain interface; other site 1173026011199 AMIN domain; Region: AMIN; pfam11741 1173026011200 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1173026011201 Cupin domain; Region: Cupin_2; cl17218 1173026011202 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173026011203 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1173026011204 S17 interaction site [polypeptide binding]; other site 1173026011205 S8 interaction site; other site 1173026011206 16S rRNA interaction site [nucleotide binding]; other site 1173026011207 streptomycin interaction site [chemical binding]; other site 1173026011208 23S rRNA interaction site [nucleotide binding]; other site 1173026011209 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1173026011210 30S ribosomal protein S7; Validated; Region: PRK05302 1173026011211 elongation factor G; Reviewed; Region: PRK00007 1173026011212 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1173026011213 G1 box; other site 1173026011214 putative GEF interaction site [polypeptide binding]; other site 1173026011215 GTP/Mg2+ binding site [chemical binding]; other site 1173026011216 Switch I region; other site 1173026011217 G2 box; other site 1173026011218 G3 box; other site 1173026011219 Switch II region; other site 1173026011220 G4 box; other site 1173026011221 G5 box; other site 1173026011222 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173026011223 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173026011224 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173026011225 elongation factor Tu; Region: tufA; CHL00071 1173026011226 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1173026011227 G1 box; other site 1173026011228 GEF interaction site [polypeptide binding]; other site 1173026011229 GTP/Mg2+ binding site [chemical binding]; other site 1173026011230 Switch I region; other site 1173026011231 G2 box; other site 1173026011232 G3 box; other site 1173026011233 Switch II region; other site 1173026011234 G4 box; other site 1173026011235 G5 box; other site 1173026011236 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1173026011237 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1173026011238 Antibiotic Binding Site [chemical binding]; other site 1173026011239 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1173026011240 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1173026011241 prephenate dehydratase; Provisional; Region: PRK11898 1173026011242 Prephenate dehydratase; Region: PDT; pfam00800 1173026011243 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1173026011244 putative L-Phe binding site [chemical binding]; other site 1173026011245 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 1173026011246 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1173026011247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026011248 FeS/SAM binding site; other site 1173026011249 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173026011250 Zn2+ binding site [ion binding]; other site 1173026011251 Mg2+ binding site [ion binding]; other site 1173026011252 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1173026011253 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 1173026011254 L-asparaginase II; Region: Asparaginase_II; cl01842 1173026011255 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1173026011256 classical (c) SDRs; Region: SDR_c; cd05233 1173026011257 NAD(P) binding site [chemical binding]; other site 1173026011258 active site 1173026011259 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026011260 active site 1173026011261 catalytic residues [active] 1173026011262 DNA binding site [nucleotide binding] 1173026011263 Int/Topo IB signature motif; other site 1173026011264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026011265 non-specific DNA binding site [nucleotide binding]; other site 1173026011266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173026011267 salt bridge; other site 1173026011268 sequence-specific DNA binding site [nucleotide binding]; other site 1173026011269 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1173026011270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1173026011271 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173026011272 G1 box; other site 1173026011273 GTP/Mg2+ binding site [chemical binding]; other site 1173026011274 G3 box; other site 1173026011275 Switch II region; other site 1173026011276 G4 box; other site 1173026011277 G5 box; other site 1173026011278 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173026011279 Dynamin family; Region: Dynamin_N; pfam00350 1173026011280 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1173026011281 G1 box; other site 1173026011282 GTP/Mg2+ binding site [chemical binding]; other site 1173026011283 Switch I region; other site 1173026011284 G2 box; other site 1173026011285 Switch II region; other site 1173026011286 G3 box; other site 1173026011287 G4 box; other site 1173026011288 G5 box; other site 1173026011289 Domain of unknown function (DUF697); Region: DUF697; pfam05128 1173026011290 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1173026011291 ABC1 family; Region: ABC1; cl17513 1173026011292 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1173026011293 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173026011294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026011295 dimerization interface [polypeptide binding]; other site 1173026011296 putative DNA binding site [nucleotide binding]; other site 1173026011297 putative Zn2+ binding site [ion binding]; other site 1173026011298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026011299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026011300 NAD(P) binding site [chemical binding]; other site 1173026011301 active site 1173026011302 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1173026011303 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1173026011304 Zn binding site [ion binding]; other site 1173026011305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026011306 S-adenosylmethionine binding site [chemical binding]; other site 1173026011307 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173026011308 active site 1173026011309 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1173026011310 active site 1173026011311 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1173026011312 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1173026011313 putative active site [active] 1173026011314 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1173026011315 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1173026011316 HSP70 interaction site [polypeptide binding]; other site 1173026011317 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173026011318 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173026011319 dimer interface [polypeptide binding]; other site 1173026011320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026011321 catalytic residue [active] 1173026011322 Predicted transcriptional regulator [Transcription]; Region: COG1959 1173026011323 Transcriptional regulator; Region: Rrf2; pfam02082 1173026011324 S-layer homology domain; Region: SLH; pfam00395 1173026011325 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026011326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026011327 Ligand Binding Site [chemical binding]; other site 1173026011328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026011329 Ligand Binding Site [chemical binding]; other site 1173026011330 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 1173026011331 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026011332 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026011333 catalytic loop [active] 1173026011334 iron binding site [ion binding]; other site 1173026011335 Predicted transcriptional regulators [Transcription]; Region: COG1695 1173026011336 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1173026011337 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026011338 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026011339 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1173026011340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026011341 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173026011342 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173026011343 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1173026011344 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173026011345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026011346 TPR repeat; Region: TPR_11; pfam13414 1173026011347 binding surface 1173026011348 TPR motif; other site 1173026011349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026011350 binding surface 1173026011351 TPR repeat; Region: TPR_11; pfam13414 1173026011352 TPR motif; other site 1173026011353 TPR repeat; Region: TPR_11; pfam13414 1173026011354 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026011355 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026011356 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1173026011357 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1173026011358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026011359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026011360 S-adenosylmethionine binding site [chemical binding]; other site 1173026011361 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1173026011362 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1173026011363 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1173026011364 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1173026011365 putative active site [active] 1173026011366 putative dimer interface [polypeptide binding]; other site 1173026011367 alpha-glucosidase; Provisional; Region: PRK10137 1173026011368 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1173026011369 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026011370 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026011371 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026011372 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026011373 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026011374 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026011375 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1173026011376 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1173026011377 NAD binding site [chemical binding]; other site 1173026011378 homodimer interface [polypeptide binding]; other site 1173026011379 active site 1173026011380 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173026011381 Fasciclin domain; Region: Fasciclin; pfam02469 1173026011382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026011383 S-adenosylmethionine binding site [chemical binding]; other site 1173026011384 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1173026011385 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1173026011386 Ion channel; Region: Ion_trans_2; pfam07885 1173026011387 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026011388 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1173026011389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011390 active site 1173026011391 phosphorylation site [posttranslational modification] 1173026011392 intermolecular recognition site; other site 1173026011393 dimerization interface [polypeptide binding]; other site 1173026011394 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 1173026011395 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1173026011396 BON domain; Region: BON; cl02771 1173026011397 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173026011398 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1173026011399 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1173026011400 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1173026011401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1173026011402 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1173026011403 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1173026011404 motif 1; other site 1173026011405 active site 1173026011406 motif 2; other site 1173026011407 motif 3; other site 1173026011408 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1173026011409 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026011410 putative active site [active] 1173026011411 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1173026011412 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1173026011413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026011414 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173026011415 Walker A/P-loop; other site 1173026011416 ATP binding site [chemical binding]; other site 1173026011417 Q-loop/lid; other site 1173026011418 ABC transporter signature motif; other site 1173026011419 Walker B; other site 1173026011420 D-loop; other site 1173026011421 H-loop/switch region; other site 1173026011422 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1173026011423 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 1173026011424 homotrimer interaction site [polypeptide binding]; other site 1173026011425 putative active site [active] 1173026011426 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026011427 GAF domain; Region: GAF; pfam01590 1173026011428 CHASE3 domain; Region: CHASE3; pfam05227 1173026011429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011430 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026011431 putative active site [active] 1173026011432 heme pocket [chemical binding]; other site 1173026011433 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026011434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011435 putative active site [active] 1173026011436 heme pocket [chemical binding]; other site 1173026011437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011438 putative active site [active] 1173026011439 heme pocket [chemical binding]; other site 1173026011440 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026011441 GAF domain; Region: GAF_3; pfam13492 1173026011442 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026011443 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026011444 metal binding site [ion binding]; metal-binding site 1173026011445 active site 1173026011446 I-site; other site 1173026011447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1173026011448 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173026011449 putative substrate translocation pore; other site 1173026011450 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 1173026011451 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1173026011452 PYR/PP interface [polypeptide binding]; other site 1173026011453 dimer interface [polypeptide binding]; other site 1173026011454 TPP binding site [chemical binding]; other site 1173026011455 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1173026011456 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1173026011457 TPP-binding site [chemical binding]; other site 1173026011458 dimer interface [polypeptide binding]; other site 1173026011459 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1173026011460 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1173026011461 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 1173026011462 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026011463 Phycobilisome protein; Region: Phycobilisome; cl08227 1173026011464 multidrug efflux protein; Reviewed; Region: PRK01766 1173026011465 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173026011466 cation binding site [ion binding]; other site 1173026011467 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026011468 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026011469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026011470 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173026011471 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026011472 active site 1173026011473 ATP binding site [chemical binding]; other site 1173026011474 substrate binding site [chemical binding]; other site 1173026011475 activation loop (A-loop); other site 1173026011476 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026011477 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026011478 structural tetrad; other site 1173026011479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026011480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026011481 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173026011482 hypothetical protein; Provisional; Region: PRK06753 1173026011483 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1173026011484 YcfA-like protein; Region: YcfA; pfam07927 1173026011485 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1173026011486 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173026011487 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1173026011488 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026011489 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1173026011490 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1173026011491 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1173026011492 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1173026011493 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 1173026011494 active site 1173026011495 PUCC protein; Region: PUCC; pfam03209 1173026011496 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026011497 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026011498 active site 1173026011499 catalytic tetrad [active] 1173026011500 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173026011501 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1173026011502 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173026011503 ATP binding site [chemical binding]; other site 1173026011504 Mg++ binding site [ion binding]; other site 1173026011505 motif III; other site 1173026011506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026011507 nucleotide binding region [chemical binding]; other site 1173026011508 ATP-binding site [chemical binding]; other site 1173026011509 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1173026011510 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173026011511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026011512 FeS/SAM binding site; other site 1173026011513 TRAM domain; Region: TRAM; cl01282 1173026011514 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 1173026011515 phosphate binding site [ion binding]; other site 1173026011516 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1173026011517 putative active site [active] 1173026011518 substrate binding site [chemical binding]; other site 1173026011519 redox center [active] 1173026011520 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026011521 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173026011522 CHASE2 domain; Region: CHASE2; pfam05226 1173026011523 PAS domain S-box; Region: sensory_box; TIGR00229 1173026011524 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011525 putative active site [active] 1173026011526 heme pocket [chemical binding]; other site 1173026011527 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026011528 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026011529 metal binding site [ion binding]; metal-binding site 1173026011530 active site 1173026011531 I-site; other site 1173026011532 L-aspartate oxidase; Provisional; Region: PRK07395 1173026011533 L-aspartate oxidase; Provisional; Region: PRK06175 1173026011534 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1173026011535 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 1173026011536 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 1173026011537 Bacitracin resistance protein BacA; Region: BacA; pfam02673 1173026011538 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1173026011539 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 1173026011540 Protein of unknown function (DUF512); Region: DUF512; pfam04459 1173026011541 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1173026011542 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173026011543 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1173026011544 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1173026011545 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1173026011546 trimer interface [polypeptide binding]; other site 1173026011547 active site 1173026011548 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1173026011549 catalytic site [active] 1173026011550 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026011551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011552 putative active site [active] 1173026011553 heme pocket [chemical binding]; other site 1173026011554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026011555 dimer interface [polypeptide binding]; other site 1173026011556 phosphorylation site [posttranslational modification] 1173026011557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026011558 ATP binding site [chemical binding]; other site 1173026011559 Mg2+ binding site [ion binding]; other site 1173026011560 G-X-G motif; other site 1173026011561 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026011562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011563 active site 1173026011564 phosphorylation site [posttranslational modification] 1173026011565 intermolecular recognition site; other site 1173026011566 dimerization interface [polypeptide binding]; other site 1173026011567 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1173026011568 active site 1173026011569 catalytic triad [active] 1173026011570 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026011571 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1173026011572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026011573 motif II; other site 1173026011574 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1173026011575 PAS domain S-box; Region: sensory_box; TIGR00229 1173026011576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011577 putative active site [active] 1173026011578 heme pocket [chemical binding]; other site 1173026011579 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026011580 GAF domain; Region: GAF; pfam01590 1173026011581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011582 putative active site [active] 1173026011583 PAS fold; Region: PAS_3; pfam08447 1173026011584 heme pocket [chemical binding]; other site 1173026011585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173026011586 Histidine kinase; Region: HisKA_2; pfam07568 1173026011587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026011588 ATP binding site [chemical binding]; other site 1173026011589 Mg2+ binding site [ion binding]; other site 1173026011590 G-X-G motif; other site 1173026011591 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026011592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011593 active site 1173026011594 phosphorylation site [posttranslational modification] 1173026011595 intermolecular recognition site; other site 1173026011596 dimerization interface [polypeptide binding]; other site 1173026011597 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026011598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011599 putative active site [active] 1173026011600 heme pocket [chemical binding]; other site 1173026011601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026011602 dimer interface [polypeptide binding]; other site 1173026011603 phosphorylation site [posttranslational modification] 1173026011604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026011605 ATP binding site [chemical binding]; other site 1173026011606 Mg2+ binding site [ion binding]; other site 1173026011607 G-X-G motif; other site 1173026011608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026011609 binding surface 1173026011610 TPR motif; other site 1173026011611 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1173026011612 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1173026011613 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1173026011614 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 1173026011615 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1173026011616 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026011617 FeS/SAM binding site; other site 1173026011618 TRAM domain; Region: TRAM; pfam01938 1173026011619 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1173026011620 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1173026011621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026011622 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1173026011623 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1173026011624 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1173026011625 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173026011626 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173026011627 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 1173026011628 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1173026011629 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1173026011630 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1173026011631 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1173026011632 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1173026011633 active site 1173026011634 dimer interface [polypeptide binding]; other site 1173026011635 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1173026011636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026011637 S-adenosylmethionine binding site [chemical binding]; other site 1173026011638 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1173026011639 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173026011640 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026011641 non-specific DNA binding site [nucleotide binding]; other site 1173026011642 salt bridge; other site 1173026011643 sequence-specific DNA binding site [nucleotide binding]; other site 1173026011644 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026011645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011646 active site 1173026011647 phosphorylation site [posttranslational modification] 1173026011648 intermolecular recognition site; other site 1173026011649 dimerization interface [polypeptide binding]; other site 1173026011650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026011651 DNA binding site [nucleotide binding] 1173026011652 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1173026011653 putative binding surface; other site 1173026011654 active site 1173026011655 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026011656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011657 active site 1173026011658 phosphorylation site [posttranslational modification] 1173026011659 intermolecular recognition site; other site 1173026011660 dimerization interface [polypeptide binding]; other site 1173026011661 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026011662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011663 active site 1173026011664 phosphorylation site [posttranslational modification] 1173026011665 intermolecular recognition site; other site 1173026011666 dimerization interface [polypeptide binding]; other site 1173026011667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026011668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026011669 metal binding site [ion binding]; metal-binding site 1173026011670 active site 1173026011671 I-site; other site 1173026011672 CHASE3 domain; Region: CHASE3; pfam05227 1173026011673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011674 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026011675 putative active site [active] 1173026011676 heme pocket [chemical binding]; other site 1173026011677 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1173026011678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011679 putative active site [active] 1173026011680 heme pocket [chemical binding]; other site 1173026011681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026011682 dimer interface [polypeptide binding]; other site 1173026011683 phosphorylation site [posttranslational modification] 1173026011684 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1173026011685 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026011686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011687 active site 1173026011688 phosphorylation site [posttranslational modification] 1173026011689 intermolecular recognition site; other site 1173026011690 dimerization interface [polypeptide binding]; other site 1173026011691 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1173026011692 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1173026011693 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1173026011694 DNA binding residues [nucleotide binding] 1173026011695 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1173026011696 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173026011697 putative NAD(P) binding site [chemical binding]; other site 1173026011698 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1173026011699 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1173026011700 active site 1173026011701 FMN binding site [chemical binding]; other site 1173026011702 substrate binding site [chemical binding]; other site 1173026011703 homotetramer interface [polypeptide binding]; other site 1173026011704 catalytic residue [active] 1173026011705 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026011706 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026011707 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173026011708 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1173026011709 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1173026011710 C-terminal domain interface [polypeptide binding]; other site 1173026011711 GSH binding site (G-site) [chemical binding]; other site 1173026011712 dimer interface [polypeptide binding]; other site 1173026011713 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1173026011714 N-terminal domain interface [polypeptide binding]; other site 1173026011715 putative dimer interface [polypeptide binding]; other site 1173026011716 active site 1173026011717 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026011718 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173026011719 TAP-like protein; Region: Abhydrolase_4; pfam08386 1173026011720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1173026011721 DinB superfamily; Region: DinB_2; pfam12867 1173026011722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1173026011723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026011724 putative substrate translocation pore; other site 1173026011725 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1173026011726 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1173026011727 DNA binding residues [nucleotide binding] 1173026011728 putative dimer interface [polypeptide binding]; other site 1173026011729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026011730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1173026011731 active site 1173026011732 catalytic tetrad [active] 1173026011733 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1173026011734 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1173026011735 substrate binding site [chemical binding]; other site 1173026011736 active site 1173026011737 catalytic residues [active] 1173026011738 heterodimer interface [polypeptide binding]; other site 1173026011739 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 1173026011740 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 1173026011741 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026011742 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026011743 catalytic loop [active] 1173026011744 iron binding site [ion binding]; other site 1173026011745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026011746 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026011747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026011748 Predicted esterase [General function prediction only]; Region: COG0400 1173026011749 putative hydrolase; Provisional; Region: PRK11460 1173026011750 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 1173026011751 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1173026011752 Flavoprotein; Region: Flavoprotein; pfam02441 1173026011753 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1173026011754 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 1173026011755 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1173026011756 active site residue [active] 1173026011757 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1173026011758 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1173026011759 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1173026011760 cobalamin binding residues [chemical binding]; other site 1173026011761 putative BtuC binding residues; other site 1173026011762 dimer interface [polypeptide binding]; other site 1173026011763 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026011764 PAS domain; Region: PAS_9; pfam13426 1173026011765 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1173026011766 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026011767 GAF domain; Region: GAF; pfam01590 1173026011768 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026011769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026011770 putative active site [active] 1173026011771 heme pocket [chemical binding]; other site 1173026011772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026011773 dimer interface [polypeptide binding]; other site 1173026011774 phosphorylation site [posttranslational modification] 1173026011775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026011776 ATP binding site [chemical binding]; other site 1173026011777 Mg2+ binding site [ion binding]; other site 1173026011778 G-X-G motif; other site 1173026011779 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026011780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026011781 active site 1173026011782 phosphorylation site [posttranslational modification] 1173026011783 intermolecular recognition site; other site 1173026011784 dimerization interface [polypeptide binding]; other site 1173026011785 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1173026011786 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173026011787 TPR repeat; Region: TPR_11; pfam13414 1173026011788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026011789 binding surface 1173026011790 TPR motif; other site 1173026011791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026011792 Coenzyme A binding pocket [chemical binding]; other site 1173026011793 Proline dehydrogenase; Region: Pro_dh; pfam01619 1173026011794 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1173026011795 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 1173026011796 Glutamate binding site [chemical binding]; other site 1173026011797 homodimer interface [polypeptide binding]; other site 1173026011798 NAD binding site [chemical binding]; other site 1173026011799 catalytic residues [active] 1173026011800 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1173026011801 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173026011802 Walker A/P-loop; other site 1173026011803 ATP binding site [chemical binding]; other site 1173026011804 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1173026011805 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1173026011806 ABC transporter signature motif; other site 1173026011807 Walker B; other site 1173026011808 D-loop; other site 1173026011809 H-loop/switch region; other site 1173026011810 PRC-barrel domain; Region: PRC; pfam05239 1173026011811 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026011812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1173026011813 active site 1173026011814 phosphorylation site [posttranslational modification] 1173026011815 intermolecular recognition site; other site 1173026011816 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1173026011817 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026011818 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026011819 metal binding site [ion binding]; metal-binding site 1173026011820 active site 1173026011821 I-site; other site 1173026011822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026011823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026011824 ATP binding site [chemical binding]; other site 1173026011825 Mg2+ binding site [ion binding]; other site 1173026011826 G-X-G motif; other site 1173026011827 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1173026011828 FIST N domain; Region: FIST; pfam08495 1173026011829 FIST C domain; Region: FIST_C; pfam10442 1173026011830 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 1173026011831 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1173026011832 active site 1173026011833 metal binding site [ion binding]; metal-binding site 1173026011834 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 1173026011835 putative active site [active] 1173026011836 putative metal binding site [ion binding]; other site 1173026011837 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1173026011838 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1173026011839 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173026011840 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173026011841 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173026011842 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1173026011843 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1173026011844 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1173026011845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026011846 Coenzyme A binding pocket [chemical binding]; other site 1173026011847 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 1173026011848 classical (c) SDRs; Region: SDR_c; cd05233 1173026011849 NAD(P) binding site [chemical binding]; other site 1173026011850 active site 1173026011851 short chain dehydrogenase; Provisional; Region: PRK08303 1173026011852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026011853 NAD(P) binding site [chemical binding]; other site 1173026011854 active site 1173026011855 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1173026011856 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1173026011857 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1173026011858 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 1173026011859 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173026011860 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026011861 Walker A/P-loop; other site 1173026011862 ATP binding site [chemical binding]; other site 1173026011863 Q-loop/lid; other site 1173026011864 ABC transporter signature motif; other site 1173026011865 Walker B; other site 1173026011866 D-loop; other site 1173026011867 H-loop/switch region; other site 1173026011868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1173026011869 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1173026011870 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026011871 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1173026011872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026011873 motif II; other site 1173026011874 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1173026011875 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1173026011876 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1173026011877 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173026011878 Ligand Binding Site [chemical binding]; other site 1173026011879 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1173026011880 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026011881 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026011882 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026011883 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026011884 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1173026011885 amidase catalytic site [active] 1173026011886 Zn binding residues [ion binding]; other site 1173026011887 substrate binding site [chemical binding]; other site 1173026011888 Bacteriorhodopsin [General function prediction only]; Region: COG5524 1173026011889 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1173026011890 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173026011891 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173026011892 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1173026011893 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1173026011894 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1173026011895 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1173026011896 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026011897 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026011898 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1173026011899 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1173026011900 amino acid transporter; Region: 2A0306; TIGR00909 1173026011901 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 1173026011902 active site 1173026011903 catalytic site [active] 1173026011904 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1173026011905 putative FMN binding site [chemical binding]; other site 1173026011906 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026011907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026011908 active site 1173026011909 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173026011910 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173026011911 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173026011912 putative active site [active] 1173026011913 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1173026011914 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1173026011915 putative ribose interaction site [chemical binding]; other site 1173026011916 putative ADP binding site [chemical binding]; other site 1173026011917 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1173026011918 active site 1173026011919 nucleotide binding site [chemical binding]; other site 1173026011920 HIGH motif; other site 1173026011921 KMSKS motif; other site 1173026011922 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1173026011923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026011924 active site 1173026011925 motif I; other site 1173026011926 motif II; other site 1173026011927 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173026011928 classical (c) SDRs; Region: SDR_c; cd05233 1173026011929 NAD(P) binding site [chemical binding]; other site 1173026011930 active site 1173026011931 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173026011932 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1173026011933 putative ADP-binding pocket [chemical binding]; other site 1173026011934 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1173026011935 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1173026011936 dimer interface [polypeptide binding]; other site 1173026011937 active site 1173026011938 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011939 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026011940 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026011941 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173026011942 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173026011943 putative active site [active] 1173026011944 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173026011945 putative ADP-binding pocket [chemical binding]; other site 1173026011946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011947 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1173026011948 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1173026011949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026011950 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026011951 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173026011952 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173026011953 putative active site [active] 1173026011954 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1173026011955 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1173026011956 putative active site [active] 1173026011957 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1173026011958 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1173026011959 nucleotide binding pocket [chemical binding]; other site 1173026011960 K-X-D-G motif; other site 1173026011961 catalytic site [active] 1173026011962 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1173026011963 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1173026011964 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1173026011965 Dimer interface [polypeptide binding]; other site 1173026011966 BRCT sequence motif; other site 1173026011967 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1173026011968 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173026011969 ABC-ATPase subunit interface; other site 1173026011970 dimer interface [polypeptide binding]; other site 1173026011971 putative PBP binding regions; other site 1173026011972 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1173026011973 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1173026011974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173026011975 ABC-ATPase subunit interface; other site 1173026011976 dimer interface [polypeptide binding]; other site 1173026011977 putative PBP binding regions; other site 1173026011978 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1173026011979 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1173026011980 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1173026011981 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1173026011982 NAD binding site [chemical binding]; other site 1173026011983 substrate binding site [chemical binding]; other site 1173026011984 homodimer interface [polypeptide binding]; other site 1173026011985 active site 1173026011986 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1173026011987 active site 1173026011988 SAM binding site [chemical binding]; other site 1173026011989 homodimer interface [polypeptide binding]; other site 1173026011990 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1173026011991 PGAP1-like protein; Region: PGAP1; pfam07819 1173026011992 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1173026011993 interchain domain interface [polypeptide binding]; other site 1173026011994 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1173026011995 heme bL binding site [chemical binding]; other site 1173026011996 intrachain domain interface; other site 1173026011997 heme bH binding site [chemical binding]; other site 1173026011998 Qo binding site; other site 1173026011999 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173026012000 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026012001 TrkA-N domain; Region: TrkA_N; pfam02254 1173026012002 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173026012003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026012004 Coenzyme A binding pocket [chemical binding]; other site 1173026012005 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1173026012006 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1173026012007 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1173026012008 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1173026012009 DNA binding site [nucleotide binding] 1173026012010 active site 1173026012011 Predicted transcriptional regulators [Transcription]; Region: COG1733 1173026012012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026012013 dimerization interface [polypeptide binding]; other site 1173026012014 putative DNA binding site [nucleotide binding]; other site 1173026012015 putative Zn2+ binding site [ion binding]; other site 1173026012016 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173026012017 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1173026012018 putative NAD(P) binding site [chemical binding]; other site 1173026012019 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1173026012020 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173026012021 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 1173026012022 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1173026012023 MltA specific insert domain; Region: MltA; pfam03562 1173026012024 3D domain; Region: 3D; pfam06725 1173026012025 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1173026012026 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1173026012027 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1173026012028 Sulfatase; Region: Sulfatase; pfam00884 1173026012029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1173026012030 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026012031 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026012032 PAS domain; Region: PAS; smart00091 1173026012033 histidine kinase; Provisional; Region: PRK13557 1173026012034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026012035 putative active site [active] 1173026012036 heme pocket [chemical binding]; other site 1173026012037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026012038 dimer interface [polypeptide binding]; other site 1173026012039 phosphorylation site [posttranslational modification] 1173026012040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012041 ATP binding site [chemical binding]; other site 1173026012042 Mg2+ binding site [ion binding]; other site 1173026012043 G-X-G motif; other site 1173026012044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012045 active site 1173026012046 phosphorylation site [posttranslational modification] 1173026012047 intermolecular recognition site; other site 1173026012048 dimerization interface [polypeptide binding]; other site 1173026012049 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1173026012050 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1173026012051 dimer interface [polypeptide binding]; other site 1173026012052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026012053 catalytic residue [active] 1173026012054 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1173026012055 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1173026012056 Active Sites [active] 1173026012057 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1173026012058 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1173026012059 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1173026012060 TPP-binding site [chemical binding]; other site 1173026012061 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1173026012062 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 1173026012063 Cytochrome P450; Region: p450; cl12078 1173026012064 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1173026012065 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1173026012066 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026012067 putative active site [active] 1173026012068 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026012069 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1173026012070 ligand binding site [chemical binding]; other site 1173026012071 flexible hinge region; other site 1173026012072 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1173026012073 ligand-binding site [chemical binding]; other site 1173026012074 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173026012075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026012076 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1173026012077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026012078 TspO/MBR family; Region: TspO_MBR; cl01379 1173026012079 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1173026012080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173026012081 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173026012082 TM-ABC transporter signature motif; other site 1173026012083 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1173026012084 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 1173026012085 putative ligand binding site [chemical binding]; other site 1173026012086 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1173026012087 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 1173026012088 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1173026012089 active site 1173026012090 catalytic residues [active] 1173026012091 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1173026012092 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1173026012093 MOSC domain; Region: MOSC; pfam03473 1173026012094 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173026012095 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1173026012096 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1173026012097 active site 1173026012098 ADP/pyrophosphate binding site [chemical binding]; other site 1173026012099 dimerization interface [polypeptide binding]; other site 1173026012100 allosteric effector site; other site 1173026012101 fructose-1,6-bisphosphate binding site; other site 1173026012102 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1173026012103 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1173026012104 putative active site [active] 1173026012105 putative FMN binding site [chemical binding]; other site 1173026012106 putative substrate binding site [chemical binding]; other site 1173026012107 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1173026012108 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1173026012109 Cl- selectivity filter; other site 1173026012110 Cl- binding residues [ion binding]; other site 1173026012111 pore gating glutamate residue; other site 1173026012112 dimer interface [polypeptide binding]; other site 1173026012113 H+/Cl- coupling transport residue; other site 1173026012114 FOG: CBS domain [General function prediction only]; Region: COG0517 1173026012115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1173026012116 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 1173026012117 Ligand Binding Site [chemical binding]; other site 1173026012118 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026012119 Ligand Binding Site [chemical binding]; other site 1173026012120 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1173026012121 active site 1173026012122 catalytic triad [active] 1173026012123 oxyanion hole [active] 1173026012124 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 1173026012125 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1173026012126 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1173026012127 putative NAD(P) binding site [chemical binding]; other site 1173026012128 homodimer interface [polypeptide binding]; other site 1173026012129 homotetramer interface [polypeptide binding]; other site 1173026012130 active site 1173026012131 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1173026012132 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1173026012133 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1173026012134 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1173026012135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026012136 NAD(P) binding site [chemical binding]; other site 1173026012137 short chain dehydrogenase; Validated; Region: PRK07069 1173026012138 active site 1173026012139 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1173026012140 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1173026012141 molybdopterin cofactor binding site; other site 1173026012142 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1173026012143 molybdopterin cofactor binding site; other site 1173026012144 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 1173026012145 active site 1173026012146 catalytic site [active] 1173026012147 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1173026012148 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026012149 FeS/SAM binding site; other site 1173026012150 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1173026012151 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026012152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012153 S-adenosylmethionine binding site [chemical binding]; other site 1173026012154 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1173026012155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012156 dimer interface [polypeptide binding]; other site 1173026012157 conserved gate region; other site 1173026012158 putative PBP binding loops; other site 1173026012159 ABC-ATPase subunit interface; other site 1173026012160 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1173026012161 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1173026012162 active site 1173026012163 substrate binding site [chemical binding]; other site 1173026012164 cosubstrate binding site; other site 1173026012165 catalytic site [active] 1173026012166 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173026012167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173026012168 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026012169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026012170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026012171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1173026012172 ACT domain; Region: ACT_3; pfam10000 1173026012173 Family description; Region: ACT_7; pfam13840 1173026012174 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 1173026012175 SacI restriction endonuclease; Region: RE_SacI; pfam09566 1173026012176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1173026012177 non-specific DNA binding site [nucleotide binding]; other site 1173026012178 salt bridge; other site 1173026012179 sequence-specific DNA binding site [nucleotide binding]; other site 1173026012180 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1173026012181 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1173026012182 cofactor binding site; other site 1173026012183 DNA binding site [nucleotide binding] 1173026012184 substrate interaction site [chemical binding]; other site 1173026012185 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1173026012186 hypothetical protein; Validated; Region: PRK07413 1173026012187 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173026012188 Walker A motif; other site 1173026012189 homodimer interface [polypeptide binding]; other site 1173026012190 ATP binding site [chemical binding]; other site 1173026012191 hydroxycobalamin binding site [chemical binding]; other site 1173026012192 Walker B motif; other site 1173026012193 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1173026012194 Walker A motif; other site 1173026012195 homodimer interface [polypeptide binding]; other site 1173026012196 ATP binding site [chemical binding]; other site 1173026012197 hydroxycobalamin binding site [chemical binding]; other site 1173026012198 Walker B motif; other site 1173026012199 Putative integral membrane protein (DUF2391); Region: DUF2391; cl01935 1173026012200 TIGR02588 family protein; Region: TIGR02588 1173026012201 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1173026012202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012203 binding surface 1173026012204 TPR motif; other site 1173026012205 TPR repeat; Region: TPR_11; pfam13414 1173026012206 TPR repeat; Region: TPR_11; pfam13414 1173026012207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012208 binding surface 1173026012209 TPR motif; other site 1173026012210 TPR repeat; Region: TPR_11; pfam13414 1173026012211 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1173026012212 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1173026012213 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1173026012214 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1173026012215 hypothetical protein; Provisional; Region: PRK04194 1173026012216 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1173026012217 Bacterial SH3 domain; Region: SH3_3; pfam08239 1173026012218 phosphodiesterase YaeI; Provisional; Region: PRK11340 1173026012219 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1173026012220 putative active site [active] 1173026012221 putative metal binding site [ion binding]; other site 1173026012222 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1173026012223 agmatinase; Region: agmatinase; TIGR01230 1173026012224 oligomer interface [polypeptide binding]; other site 1173026012225 putative active site [active] 1173026012226 Mn binding site [ion binding]; other site 1173026012227 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1173026012228 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1173026012229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026012230 putative DNA binding site [nucleotide binding]; other site 1173026012231 putative Zn2+ binding site [ion binding]; other site 1173026012232 AsnC family; Region: AsnC_trans_reg; pfam01037 1173026012233 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173026012234 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173026012235 [2Fe-2S] cluster binding site [ion binding]; other site 1173026012236 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173026012237 hydrophobic ligand binding site; other site 1173026012238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173026012239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173026012240 substrate binding pocket [chemical binding]; other site 1173026012241 membrane-bound complex binding site; other site 1173026012242 hinge residues; other site 1173026012243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012244 dimer interface [polypeptide binding]; other site 1173026012245 conserved gate region; other site 1173026012246 putative PBP binding loops; other site 1173026012247 ABC-ATPase subunit interface; other site 1173026012248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012249 dimer interface [polypeptide binding]; other site 1173026012250 conserved gate region; other site 1173026012251 putative PBP binding loops; other site 1173026012252 ABC-ATPase subunit interface; other site 1173026012253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173026012254 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173026012255 Walker A/P-loop; other site 1173026012256 ATP binding site [chemical binding]; other site 1173026012257 Q-loop/lid; other site 1173026012258 ABC transporter signature motif; other site 1173026012259 Walker B; other site 1173026012260 D-loop; other site 1173026012261 H-loop/switch region; other site 1173026012262 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1173026012263 SnoaL-like domain; Region: SnoaL_3; pfam13474 1173026012264 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1173026012265 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 1173026012266 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 1173026012267 Yip1 domain; Region: Yip1; pfam04893 1173026012268 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 1173026012269 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 1173026012270 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1173026012271 Membrane protein of unknown function; Region: DUF360; cl00850 1173026012272 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1173026012273 substrate binding site [chemical binding]; other site 1173026012274 putative lipid kinase; Reviewed; Region: PRK00861 1173026012275 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1173026012276 PEGA domain; Region: PEGA; pfam08308 1173026012277 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 1173026012278 Predicted transcriptional regulator [Transcription]; Region: COG2944 1173026012279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026012280 non-specific DNA binding site [nucleotide binding]; other site 1173026012281 salt bridge; other site 1173026012282 sequence-specific DNA binding site [nucleotide binding]; other site 1173026012283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173026012284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026012285 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1173026012286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026012287 NAD(P) binding site [chemical binding]; other site 1173026012288 active site 1173026012289 multidrug efflux protein; Reviewed; Region: PRK01766 1173026012290 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1173026012291 cation binding site [ion binding]; other site 1173026012292 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1173026012293 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1173026012294 putative NAD(P) binding site [chemical binding]; other site 1173026012295 YrhK-like protein; Region: YrhK; pfam14145 1173026012296 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173026012297 apocytochrome f; Reviewed; Region: PRK02693 1173026012298 cytochrome f; Region: petA; CHL00037 1173026012299 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 1173026012300 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1173026012301 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 1173026012302 cytochrome b subunit interaction site [polypeptide binding]; other site 1173026012303 [2Fe-2S] cluster binding site [ion binding]; other site 1173026012304 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 1173026012305 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1173026012306 dimer interface [polypeptide binding]; other site 1173026012307 putative tRNA-binding site [nucleotide binding]; other site 1173026012308 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 1173026012309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026012310 binding surface 1173026012311 TPR motif; other site 1173026012312 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1173026012313 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1173026012314 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1173026012315 catalytic residue [active] 1173026012316 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 1173026012317 putative homodimer interface [polypeptide binding]; other site 1173026012318 putative homotetramer interface [polypeptide binding]; other site 1173026012319 putative metal binding site [ion binding]; other site 1173026012320 putative homodimer-homodimer interface [polypeptide binding]; other site 1173026012321 putative allosteric switch controlling residues; other site 1173026012322 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173026012323 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173026012324 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026012325 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173026012326 glucokinase; Provisional; Region: glk; PRK00292 1173026012327 glucokinase, proteobacterial type; Region: glk; TIGR00749 1173026012328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1173026012329 catalytic core [active] 1173026012330 PIN domain; Region: PIN_3; pfam13470 1173026012331 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1173026012332 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1173026012333 Ligand Binding Site [chemical binding]; other site 1173026012334 MASE1; Region: MASE1; pfam05231 1173026012335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026012336 GAF domain; Region: GAF; pfam01590 1173026012337 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026012338 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026012339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026012340 dimer interface [polypeptide binding]; other site 1173026012341 phosphorylation site [posttranslational modification] 1173026012342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012343 ATP binding site [chemical binding]; other site 1173026012344 Mg2+ binding site [ion binding]; other site 1173026012345 G-X-G motif; other site 1173026012346 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026012347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012348 active site 1173026012349 phosphorylation site [posttranslational modification] 1173026012350 intermolecular recognition site; other site 1173026012351 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026012352 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026012353 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026012354 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026012355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026012356 dimer interface [polypeptide binding]; other site 1173026012357 phosphorylation site [posttranslational modification] 1173026012358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012359 ATP binding site [chemical binding]; other site 1173026012360 Mg2+ binding site [ion binding]; other site 1173026012361 G-X-G motif; other site 1173026012362 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026012363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012364 active site 1173026012365 phosphorylation site [posttranslational modification] 1173026012366 intermolecular recognition site; other site 1173026012367 dimerization interface [polypeptide binding]; other site 1173026012368 Cache domain; Region: Cache_1; pfam02743 1173026012369 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1173026012370 dimerization interface [polypeptide binding]; other site 1173026012371 PAS fold; Region: PAS_3; pfam08447 1173026012372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026012373 putative active site [active] 1173026012374 heme pocket [chemical binding]; other site 1173026012375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026012376 dimer interface [polypeptide binding]; other site 1173026012377 phosphorylation site [posttranslational modification] 1173026012378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012379 ATP binding site [chemical binding]; other site 1173026012380 Mg2+ binding site [ion binding]; other site 1173026012381 G-X-G motif; other site 1173026012382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026012383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026012384 dimer interface [polypeptide binding]; other site 1173026012385 phosphorylation site [posttranslational modification] 1173026012386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012387 ATP binding site [chemical binding]; other site 1173026012388 Mg2+ binding site [ion binding]; other site 1173026012389 G-X-G motif; other site 1173026012390 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026012391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012392 active site 1173026012393 phosphorylation site [posttranslational modification] 1173026012394 intermolecular recognition site; other site 1173026012395 dimerization interface [polypeptide binding]; other site 1173026012396 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1173026012397 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1173026012398 TM-ABC transporter signature motif; other site 1173026012399 PsaX family; Region: PsaX; pfam08078 1173026012400 lipoyl synthase; Provisional; Region: PRK12928 1173026012401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1173026012402 FeS/SAM binding site; other site 1173026012403 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026012404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012405 active site 1173026012406 phosphorylation site [posttranslational modification] 1173026012407 intermolecular recognition site; other site 1173026012408 dimerization interface [polypeptide binding]; other site 1173026012409 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026012410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012411 S-adenosylmethionine binding site [chemical binding]; other site 1173026012412 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1173026012413 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1173026012414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026012415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1173026012416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026012417 dimer interface [polypeptide binding]; other site 1173026012418 phosphorylation site [posttranslational modification] 1173026012419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012420 ATP binding site [chemical binding]; other site 1173026012421 Mg2+ binding site [ion binding]; other site 1173026012422 G-X-G motif; other site 1173026012423 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1173026012424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012425 active site 1173026012426 phosphorylation site [posttranslational modification] 1173026012427 intermolecular recognition site; other site 1173026012428 dimerization interface [polypeptide binding]; other site 1173026012429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026012430 Walker A motif; other site 1173026012431 ATP binding site [chemical binding]; other site 1173026012432 Walker B motif; other site 1173026012433 arginine finger; other site 1173026012434 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1173026012435 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1173026012436 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1173026012437 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1173026012438 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1173026012439 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1173026012440 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1173026012441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026012442 Walker A motif; other site 1173026012443 ATP binding site [chemical binding]; other site 1173026012444 Walker B motif; other site 1173026012445 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1173026012446 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1173026012447 nucleotide binding site/active site [active] 1173026012448 HIT family signature motif; other site 1173026012449 catalytic residue [active] 1173026012450 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 1173026012451 protein I interface; other site 1173026012452 D2 interface; other site 1173026012453 protein T interface; other site 1173026012454 chlorophyll binding site; other site 1173026012455 beta carotene binding site; other site 1173026012456 pheophytin binding site; other site 1173026012457 manganese-stabilizing polypeptide interface; other site 1173026012458 CP43 interface; other site 1173026012459 protein L interface; other site 1173026012460 oxygen evolving complex binding site; other site 1173026012461 bromide binding site; other site 1173026012462 quinone binding site; other site 1173026012463 Fe binding site [ion binding]; other site 1173026012464 core light harvesting interface; other site 1173026012465 cytochrome b559 alpha subunit interface; other site 1173026012466 cytochrome c-550 interface; other site 1173026012467 protein J interface; other site 1173026012468 recombination protein RecR; Reviewed; Region: recR; PRK00076 1173026012469 RecR protein; Region: RecR; pfam02132 1173026012470 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1173026012471 putative active site [active] 1173026012472 putative metal-binding site [ion binding]; other site 1173026012473 tetramer interface [polypeptide binding]; other site 1173026012474 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1173026012475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026012476 active site 1173026012477 phosphorylation site [posttranslational modification] 1173026012478 intermolecular recognition site; other site 1173026012479 dimerization interface [polypeptide binding]; other site 1173026012480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1173026012481 Zn2+ binding site [ion binding]; other site 1173026012482 Mg2+ binding site [ion binding]; other site 1173026012483 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 1173026012484 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1173026012485 Substrate binding site; other site 1173026012486 Mg++ binding site; other site 1173026012487 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1173026012488 active site 1173026012489 substrate binding site [chemical binding]; other site 1173026012490 CoA binding site [chemical binding]; other site 1173026012491 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026012492 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 1173026012493 active site 1173026012494 dimer interface [polypeptide binding]; other site 1173026012495 catalytic nucleophile [active] 1173026012496 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1173026012497 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1173026012498 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1173026012499 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1173026012500 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1173026012501 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1173026012502 GTP1/OBG; Region: GTP1_OBG; pfam01018 1173026012503 Obg GTPase; Region: Obg; cd01898 1173026012504 G1 box; other site 1173026012505 GTP/Mg2+ binding site [chemical binding]; other site 1173026012506 Switch I region; other site 1173026012507 G2 box; other site 1173026012508 G3 box; other site 1173026012509 Switch II region; other site 1173026012510 G4 box; other site 1173026012511 G5 box; other site 1173026012512 tellurium resistance terB-like protein; Region: terB_like; cd07177 1173026012513 metal binding site [ion binding]; metal-binding site 1173026012514 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173026012515 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1173026012516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026012517 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1173026012518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026012519 active site 1173026012520 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 1173026012521 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1173026012522 substrate binding site; other site 1173026012523 metal-binding site 1173026012524 Oligomer interface; other site 1173026012525 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1173026012526 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1173026012527 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1173026012528 NADP binding site [chemical binding]; other site 1173026012529 active site 1173026012530 putative substrate binding site [chemical binding]; other site 1173026012531 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1173026012532 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1173026012533 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026012534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012535 S-adenosylmethionine binding site [chemical binding]; other site 1173026012536 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1173026012537 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1173026012538 Ligand binding site; other site 1173026012539 Putative Catalytic site; other site 1173026012540 DXD motif; other site 1173026012541 Protein of unknown function, DUF288; Region: DUF288; pfam03385 1173026012542 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026012543 active site 1173026012544 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026012545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012546 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026012547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012548 S-adenosylmethionine binding site [chemical binding]; other site 1173026012549 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026012550 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1173026012551 Probable Catalytic site; other site 1173026012552 metal-binding site 1173026012553 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026012554 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1173026012555 Probable Catalytic site; other site 1173026012556 metal-binding site 1173026012557 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1173026012558 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1173026012559 Walker A/P-loop; other site 1173026012560 ATP binding site [chemical binding]; other site 1173026012561 Q-loop/lid; other site 1173026012562 ABC transporter signature motif; other site 1173026012563 Walker B; other site 1173026012564 D-loop; other site 1173026012565 H-loop/switch region; other site 1173026012566 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1173026012567 putative carbohydrate binding site [chemical binding]; other site 1173026012568 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1173026012569 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173026012570 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 1173026012571 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1173026012572 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173026012573 DTAP/Switch II; other site 1173026012574 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173026012575 putative dimer interface [polypeptide binding]; other site 1173026012576 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1173026012577 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173026012578 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 1173026012579 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1173026012580 tandem repeat interface [polypeptide binding]; other site 1173026012581 oligomer interface [polypeptide binding]; other site 1173026012582 active site residues [active] 1173026012583 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1173026012584 tandem repeat interface [polypeptide binding]; other site 1173026012585 oligomer interface [polypeptide binding]; other site 1173026012586 active site residues [active] 1173026012587 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173026012588 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173026012589 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1173026012590 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1173026012591 TPR repeat; Region: TPR_11; pfam13414 1173026012592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012593 binding surface 1173026012594 TPR motif; other site 1173026012595 TPR repeat; Region: TPR_11; pfam13414 1173026012596 TPR repeat; Region: TPR_11; pfam13414 1173026012597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012598 binding surface 1173026012599 TPR motif; other site 1173026012600 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 1173026012601 Caspase domain; Region: Peptidase_C14; pfam00656 1173026012602 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026012603 structural tetrad; other site 1173026012604 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1173026012605 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1173026012606 structural tetrad; other site 1173026012607 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173026012608 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173026012609 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173026012610 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026012611 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026012612 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1173026012613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026012614 DNA binding residues [nucleotide binding] 1173026012615 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 1173026012616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026012617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026012618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173026012619 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173026012620 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1173026012621 PAS domain S-box; Region: sensory_box; TIGR00229 1173026012622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026012623 putative active site [active] 1173026012624 heme pocket [chemical binding]; other site 1173026012625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026012626 PAS fold; Region: PAS_3; pfam08447 1173026012627 putative active site [active] 1173026012628 heme pocket [chemical binding]; other site 1173026012629 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026012630 GAF domain; Region: GAF_3; pfam13492 1173026012631 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026012632 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026012633 metal binding site [ion binding]; metal-binding site 1173026012634 active site 1173026012635 I-site; other site 1173026012636 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1173026012637 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1173026012638 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 1173026012639 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 1173026012640 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1173026012641 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1173026012642 catalytic residues [active] 1173026012643 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026012644 putative active site [active] 1173026012645 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173026012646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026012647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173026012648 dimerization interface [polypeptide binding]; other site 1173026012649 short chain dehydrogenase; Provisional; Region: PRK06500 1173026012650 classical (c) SDRs; Region: SDR_c; cd05233 1173026012651 NAD(P) binding site [chemical binding]; other site 1173026012652 active site 1173026012653 XisH protein; Region: XisH; pfam08814 1173026012654 XisI protein; Region: XisI; pfam08869 1173026012655 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026012656 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026012657 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1173026012658 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026012659 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026012660 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1173026012661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026012662 non-specific DNA binding site [nucleotide binding]; other site 1173026012663 salt bridge; other site 1173026012664 sequence-specific DNA binding site [nucleotide binding]; other site 1173026012665 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1173026012666 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173026012667 DNA binding residues [nucleotide binding] 1173026012668 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 1173026012669 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1173026012670 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 1173026012671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012672 S-adenosylmethionine binding site [chemical binding]; other site 1173026012673 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1173026012674 hypothetical protein; Provisional; Region: PRK02724 1173026012675 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 1173026012676 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 1173026012677 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173026012678 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173026012679 active site 1173026012680 TDP-binding site; other site 1173026012681 acceptor substrate-binding pocket; other site 1173026012682 homodimer interface [polypeptide binding]; other site 1173026012683 TPR repeat; Region: TPR_11; pfam13414 1173026012684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012685 binding surface 1173026012686 TPR motif; other site 1173026012687 TPR repeat; Region: TPR_11; pfam13414 1173026012688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012689 binding surface 1173026012690 TPR motif; other site 1173026012691 TPR repeat; Region: TPR_11; pfam13414 1173026012692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026012693 binding surface 1173026012694 TPR motif; other site 1173026012695 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1173026012696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026012697 Walker A motif; other site 1173026012698 ATP binding site [chemical binding]; other site 1173026012699 Walker B motif; other site 1173026012700 arginine finger; other site 1173026012701 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1173026012702 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1173026012703 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1173026012704 substrate binding site [chemical binding]; other site 1173026012705 glutamase interaction surface [polypeptide binding]; other site 1173026012706 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1173026012707 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173026012708 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026012709 Walker A/P-loop; other site 1173026012710 ATP binding site [chemical binding]; other site 1173026012711 Q-loop/lid; other site 1173026012712 ABC transporter signature motif; other site 1173026012713 Walker B; other site 1173026012714 D-loop; other site 1173026012715 H-loop/switch region; other site 1173026012716 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026012717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012718 dimer interface [polypeptide binding]; other site 1173026012719 conserved gate region; other site 1173026012720 putative PBP binding loops; other site 1173026012721 ABC-ATPase subunit interface; other site 1173026012722 NMT1-like family; Region: NMT1_2; pfam13379 1173026012723 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173026012724 substrate binding pocket [chemical binding]; other site 1173026012725 membrane-bound complex binding site; other site 1173026012726 hinge residues; other site 1173026012727 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1173026012728 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026012729 active site 1173026012730 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173026012731 Amidase; Region: Amidase; pfam01425 1173026012732 dihydropyrimidinase; Provisional; Region: PRK13404 1173026012733 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1173026012734 tetramer interface [polypeptide binding]; other site 1173026012735 active site 1173026012736 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1173026012737 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1173026012738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026012739 DNA-binding site [nucleotide binding]; DNA binding site 1173026012740 FCD domain; Region: FCD; pfam07729 1173026012741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1173026012742 amidase; Provisional; Region: PRK09201 1173026012743 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1173026012744 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173026012745 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1173026012746 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1173026012747 active site 1173026012748 homotetramer interface [polypeptide binding]; other site 1173026012749 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1173026012750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012751 dimer interface [polypeptide binding]; other site 1173026012752 conserved gate region; other site 1173026012753 putative PBP binding loops; other site 1173026012754 ABC-ATPase subunit interface; other site 1173026012755 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1173026012756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012757 dimer interface [polypeptide binding]; other site 1173026012758 conserved gate region; other site 1173026012759 putative PBP binding loops; other site 1173026012760 ABC-ATPase subunit interface; other site 1173026012761 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173026012762 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026012763 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173026012764 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173026012765 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1173026012766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026012767 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173026012768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026012769 Walker A/P-loop; other site 1173026012770 ATP binding site [chemical binding]; other site 1173026012771 Q-loop/lid; other site 1173026012772 ABC transporter signature motif; other site 1173026012773 Walker B; other site 1173026012774 D-loop; other site 1173026012775 H-loop/switch region; other site 1173026012776 TOBE domain; Region: TOBE_2; pfam08402 1173026012777 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1173026012778 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173026012779 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1173026012780 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026012781 active site 1173026012782 hypothetical protein; Provisional; Region: PRK09256 1173026012783 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1173026012784 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1173026012785 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1173026012786 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1173026012787 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1173026012788 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1173026012789 Walker A/P-loop; other site 1173026012790 ATP binding site [chemical binding]; other site 1173026012791 Q-loop/lid; other site 1173026012792 ABC transporter signature motif; other site 1173026012793 Walker B; other site 1173026012794 D-loop; other site 1173026012795 H-loop/switch region; other site 1173026012796 TOBE domain; Region: TOBE_2; pfam08402 1173026012797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1173026012798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012799 conserved gate region; other site 1173026012800 dimer interface [polypeptide binding]; other site 1173026012801 ABC-ATPase subunit interface; other site 1173026012802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012803 dimer interface [polypeptide binding]; other site 1173026012804 conserved gate region; other site 1173026012805 putative PBP binding loops; other site 1173026012806 ABC-ATPase subunit interface; other site 1173026012807 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1173026012808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1173026012809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1173026012810 classical (c) SDRs; Region: SDR_c; cd05233 1173026012811 NAD(P) binding site [chemical binding]; other site 1173026012812 active site 1173026012813 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1173026012814 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1173026012815 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1173026012816 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1173026012817 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1173026012818 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1173026012819 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1173026012820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026012821 motif II; other site 1173026012822 sucrose synthase; Region: sucr_synth; TIGR02470 1173026012823 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1173026012824 putative ADP-binding pocket [chemical binding]; other site 1173026012825 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173026012826 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026012827 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026012828 PAS domain S-box; Region: sensory_box; TIGR00229 1173026012829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026012830 putative active site [active] 1173026012831 heme pocket [chemical binding]; other site 1173026012832 PAS domain S-box; Region: sensory_box; TIGR00229 1173026012833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026012834 putative active site [active] 1173026012835 heme pocket [chemical binding]; other site 1173026012836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026012837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026012838 metal binding site [ion binding]; metal-binding site 1173026012839 active site 1173026012840 I-site; other site 1173026012841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026012842 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026012843 putative active site [active] 1173026012844 Cupin domain; Region: Cupin_2; cl17218 1173026012845 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026012846 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026012847 active site 1173026012848 ATP binding site [chemical binding]; other site 1173026012849 substrate binding site [chemical binding]; other site 1173026012850 activation loop (A-loop); other site 1173026012851 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1173026012852 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1173026012853 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1173026012854 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1173026012855 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1173026012856 active site 1173026012857 dimer interface [polypeptide binding]; other site 1173026012858 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1173026012859 dimer interface [polypeptide binding]; other site 1173026012860 active site 1173026012861 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1173026012862 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173026012863 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1173026012864 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173026012865 TM-ABC transporter signature motif; other site 1173026012866 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1173026012867 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173026012868 Walker A/P-loop; other site 1173026012869 ATP binding site [chemical binding]; other site 1173026012870 Q-loop/lid; other site 1173026012871 ABC transporter signature motif; other site 1173026012872 Walker B; other site 1173026012873 D-loop; other site 1173026012874 H-loop/switch region; other site 1173026012875 S-layer homology domain; Region: SLH; pfam00395 1173026012876 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026012877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173026012878 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1173026012879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026012880 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1173026012881 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1173026012882 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1173026012883 putative NAD(P) binding site [chemical binding]; other site 1173026012884 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1173026012885 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173026012886 putative di-iron ligands [ion binding]; other site 1173026012887 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1173026012888 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026012889 GAF domain; Region: GAF; pfam01590 1173026012890 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173026012891 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026012892 Walker A/P-loop; other site 1173026012893 ATP binding site [chemical binding]; other site 1173026012894 Q-loop/lid; other site 1173026012895 ABC transporter signature motif; other site 1173026012896 Walker B; other site 1173026012897 D-loop; other site 1173026012898 H-loop/switch region; other site 1173026012899 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026012900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012901 dimer interface [polypeptide binding]; other site 1173026012902 conserved gate region; other site 1173026012903 putative PBP binding loops; other site 1173026012904 ABC-ATPase subunit interface; other site 1173026012905 Isochorismatase family; Region: Isochorismatase; pfam00857 1173026012906 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1173026012907 catalytic triad [active] 1173026012908 conserved cis-peptide bond; other site 1173026012909 NMT1-like family; Region: NMT1_2; pfam13379 1173026012910 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173026012911 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1173026012912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1173026012913 substrate binding pocket [chemical binding]; other site 1173026012914 membrane-bound complex binding site; other site 1173026012915 hinge residues; other site 1173026012916 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1173026012917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026012918 dimer interface [polypeptide binding]; other site 1173026012919 conserved gate region; other site 1173026012920 putative PBP binding loops; other site 1173026012921 ABC-ATPase subunit interface; other site 1173026012922 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1173026012923 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1173026012924 Walker A/P-loop; other site 1173026012925 ATP binding site [chemical binding]; other site 1173026012926 Q-loop/lid; other site 1173026012927 ABC transporter signature motif; other site 1173026012928 Walker B; other site 1173026012929 D-loop; other site 1173026012930 H-loop/switch region; other site 1173026012931 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1173026012932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026012933 Mg2+ binding site [ion binding]; other site 1173026012934 G-X-G motif; other site 1173026012935 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1173026012936 anchoring element; other site 1173026012937 dimer interface [polypeptide binding]; other site 1173026012938 ATP binding site [chemical binding]; other site 1173026012939 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1173026012940 active site 1173026012941 putative metal-binding site [ion binding]; other site 1173026012942 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1173026012943 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1173026012944 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1173026012945 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026012946 putative active site [active] 1173026012947 FAD binding domain; Region: FAD_binding_4; pfam01565 1173026012948 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1173026012949 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173026012950 FAD binding domain; Region: FAD_binding_4; pfam01565 1173026012951 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026012952 putative active site [active] 1173026012953 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1173026012954 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1173026012955 Cysteine-rich domain; Region: CCG; pfam02754 1173026012956 Cysteine-rich domain; Region: CCG; pfam02754 1173026012957 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1173026012958 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1173026012959 TM-ABC transporter signature motif; other site 1173026012960 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1173026012961 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1173026012962 Walker A/P-loop; other site 1173026012963 ATP binding site [chemical binding]; other site 1173026012964 Q-loop/lid; other site 1173026012965 ABC transporter signature motif; other site 1173026012966 Walker B; other site 1173026012967 D-loop; other site 1173026012968 H-loop/switch region; other site 1173026012969 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1173026012970 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1173026012971 Walker A/P-loop; other site 1173026012972 ATP binding site [chemical binding]; other site 1173026012973 Q-loop/lid; other site 1173026012974 ABC transporter signature motif; other site 1173026012975 Walker B; other site 1173026012976 D-loop; other site 1173026012977 H-loop/switch region; other site 1173026012978 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1173026012979 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1173026012980 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1173026012981 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1173026012982 Competence protein; Region: Competence; pfam03772 1173026012983 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1173026012984 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 1173026012985 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1173026012986 dimer interface [polypeptide binding]; other site 1173026012987 motif 1; other site 1173026012988 active site 1173026012989 motif 2; other site 1173026012990 motif 3; other site 1173026012991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026012992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026012993 S-adenosylmethionine binding site [chemical binding]; other site 1173026012994 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 1173026012995 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1173026012996 catalytic triad [active] 1173026012997 AB domain interface; other site 1173026012998 putative substrate binding pocket [chemical binding]; other site 1173026012999 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1173026013000 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1173026013001 putative active site [active] 1173026013002 oxyanion strand; other site 1173026013003 catalytic triad [active] 1173026013004 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1173026013005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026013006 S-adenosylmethionine binding site [chemical binding]; other site 1173026013007 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 1173026013008 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1173026013009 Cytochrome c; Region: Cytochrom_C; pfam00034 1173026013010 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026013011 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1173026013012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026013013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026013014 WHG domain; Region: WHG; pfam13305 1173026013015 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1173026013016 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026013017 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173026013018 Walker A/P-loop; other site 1173026013019 ATP binding site [chemical binding]; other site 1173026013020 Q-loop/lid; other site 1173026013021 ABC transporter signature motif; other site 1173026013022 Walker B; other site 1173026013023 D-loop; other site 1173026013024 H-loop/switch region; other site 1173026013025 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026013026 active site 1173026013027 NTP binding site [chemical binding]; other site 1173026013028 metal binding triad [ion binding]; metal-binding site 1173026013029 antibiotic binding site [chemical binding]; other site 1173026013030 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1173026013031 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173026013032 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 1173026013033 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1173026013034 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1173026013035 homotetramer interface [polypeptide binding]; other site 1173026013036 ligand binding site [chemical binding]; other site 1173026013037 catalytic site [active] 1173026013038 NAD binding site [chemical binding]; other site 1173026013039 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1173026013040 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173026013041 NMT1/THI5 like; Region: NMT1; pfam09084 1173026013042 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1173026013043 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1173026013044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026013045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026013046 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173026013047 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026013048 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026013049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026013050 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1173026013051 Coenzyme A binding pocket [chemical binding]; other site 1173026013052 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1173026013053 DevC protein; Region: devC; TIGR01185 1173026013054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026013055 FtsX-like permease family; Region: FtsX; pfam02687 1173026013056 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1173026013057 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173026013058 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026013059 Walker A/P-loop; other site 1173026013060 ATP binding site [chemical binding]; other site 1173026013061 Q-loop/lid; other site 1173026013062 ABC transporter signature motif; other site 1173026013063 Walker B; other site 1173026013064 D-loop; other site 1173026013065 H-loop/switch region; other site 1173026013066 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1173026013067 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026013068 putative active site [active] 1173026013069 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1173026013070 dimer interface [polypeptide binding]; other site 1173026013071 FMN binding site [chemical binding]; other site 1173026013072 NADPH bind site [chemical binding]; other site 1173026013073 Putative phosphatase (DUF442); Region: DUF442; cl17385 1173026013074 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1173026013075 catalytic triad [active] 1173026013076 dimer interface [polypeptide binding]; other site 1173026013077 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026013078 TraX protein; Region: TraX; cl05434 1173026013079 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1173026013080 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1173026013081 minor groove reading motif; other site 1173026013082 helix-hairpin-helix signature motif; other site 1173026013083 substrate binding pocket [chemical binding]; other site 1173026013084 active site 1173026013085 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1173026013086 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173026013087 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1173026013088 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1173026013089 Probable Catalytic site; other site 1173026013090 tocopherol O-methyltransferase; Region: PLN02244 1173026013091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026013092 S-adenosylmethionine binding site [chemical binding]; other site 1173026013093 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1173026013094 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1173026013095 GatB domain; Region: GatB_Yqey; smart00845 1173026013096 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1173026013097 heterotetramer interface [polypeptide binding]; other site 1173026013098 active site pocket [active] 1173026013099 cleavage site 1173026013100 AAA domain; Region: AAA_17; pfam13207 1173026013101 AAA domain; Region: AAA_18; pfam13238 1173026013102 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026013103 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026013104 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1173026013105 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1173026013106 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173026013107 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1173026013108 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 1173026013109 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1173026013110 putative active site [active] 1173026013111 putative metal binding site [ion binding]; other site 1173026013112 quinolinate synthetase; Provisional; Region: PRK09375 1173026013113 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 1173026013114 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1173026013115 dimerization interface [polypeptide binding]; other site 1173026013116 active site 1173026013117 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1173026013118 arginine-tRNA ligase; Region: PLN02286 1173026013119 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1173026013120 active site 1173026013121 HIGH motif; other site 1173026013122 KMSK motif region; other site 1173026013123 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1173026013124 tRNA binding surface [nucleotide binding]; other site 1173026013125 anticodon binding site; other site 1173026013126 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1173026013127 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173026013128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026013129 catalytic residue [active] 1173026013130 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 1173026013131 PLD-like domain; Region: PLDc_2; pfam13091 1173026013132 putative active site [active] 1173026013133 catalytic site [active] 1173026013134 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1173026013135 PLD-like domain; Region: PLDc_2; pfam13091 1173026013136 putative active site [active] 1173026013137 catalytic site [active] 1173026013138 Helix-hairpin-helix motif; Region: HHH; pfam00633 1173026013139 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1173026013140 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173026013141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173026013142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026013143 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1173026013144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026013145 motif II; other site 1173026013146 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 1173026013147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026013148 putative DNA binding site [nucleotide binding]; other site 1173026013149 putative Zn2+ binding site [ion binding]; other site 1173026013150 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1173026013151 putative ABC transporter; Region: ycf24; CHL00085 1173026013152 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 1173026013153 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1173026013154 Walker A/P-loop; other site 1173026013155 ATP binding site [chemical binding]; other site 1173026013156 Q-loop/lid; other site 1173026013157 ABC transporter signature motif; other site 1173026013158 Walker B; other site 1173026013159 D-loop; other site 1173026013160 H-loop/switch region; other site 1173026013161 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1173026013162 FeS assembly protein SufD; Region: sufD; TIGR01981 1173026013163 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1173026013164 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1173026013165 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026013166 catalytic residue [active] 1173026013167 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1173026013168 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1173026013169 conserved cys residue [active] 1173026013170 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026013171 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026013172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026013173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026013174 DNA binding residues [nucleotide binding] 1173026013175 dimerization interface [polypeptide binding]; other site 1173026013176 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026013177 putative active site [active] 1173026013178 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1173026013179 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1173026013180 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1173026013181 Ligand binding site; other site 1173026013182 Putative Catalytic site; other site 1173026013183 DXD motif; other site 1173026013184 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1173026013185 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1173026013186 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1173026013187 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1173026013188 active site 1173026013189 substrate binding site [chemical binding]; other site 1173026013190 catalytic site [active] 1173026013191 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1173026013192 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1173026013193 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1173026013194 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1173026013195 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1173026013196 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1173026013197 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1173026013198 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1173026013199 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026013200 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1173026013201 acyl-activating enzyme (AAE) consensus motif; other site 1173026013202 acyl-activating enzyme (AAE) consensus motif; other site 1173026013203 putative AMP binding site [chemical binding]; other site 1173026013204 putative active site [active] 1173026013205 putative CoA binding site [chemical binding]; other site 1173026013206 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1173026013207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026013208 Walker A/P-loop; other site 1173026013209 ATP binding site [chemical binding]; other site 1173026013210 Q-loop/lid; other site 1173026013211 ABC transporter signature motif; other site 1173026013212 Walker B; other site 1173026013213 D-loop; other site 1173026013214 H-loop/switch region; other site 1173026013215 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1173026013216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026013217 dimer interface [polypeptide binding]; other site 1173026013218 conserved gate region; other site 1173026013219 putative PBP binding loops; other site 1173026013220 ABC-ATPase subunit interface; other site 1173026013221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026013222 dimer interface [polypeptide binding]; other site 1173026013223 conserved gate region; other site 1173026013224 putative PBP binding loops; other site 1173026013225 ABC-ATPase subunit interface; other site 1173026013226 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1173026013227 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1173026013228 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1173026013229 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026013230 Chain length determinant protein; Region: Wzz; cl15801 1173026013231 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1173026013232 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1173026013233 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1173026013234 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1173026013235 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1173026013236 inhibitor-cofactor binding pocket; inhibition site 1173026013237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1173026013238 catalytic residue [active] 1173026013239 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1173026013240 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026013241 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026013242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026013243 S-adenosylmethionine binding site [chemical binding]; other site 1173026013244 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1173026013245 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1173026013246 putative ADP-binding pocket [chemical binding]; other site 1173026013247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026013248 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1173026013249 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1173026013250 putative ADP-binding pocket [chemical binding]; other site 1173026013251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026013252 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1173026013253 putative ADP-binding pocket [chemical binding]; other site 1173026013254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026013255 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1173026013256 putative ADP-binding pocket [chemical binding]; other site 1173026013257 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1173026013258 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 1173026013259 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1173026013260 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1173026013261 NAD(P) binding site [chemical binding]; other site 1173026013262 homodimer interface [polypeptide binding]; other site 1173026013263 substrate binding site [chemical binding]; other site 1173026013264 active site 1173026013265 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026013266 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1173026013267 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1173026013268 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1173026013269 FAD binding pocket [chemical binding]; other site 1173026013270 FAD binding motif [chemical binding]; other site 1173026013271 phosphate binding motif [ion binding]; other site 1173026013272 beta-alpha-beta structure motif; other site 1173026013273 NAD binding pocket [chemical binding]; other site 1173026013274 Predicted membrane protein [Function unknown]; Region: COG1950 1173026013275 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1173026013276 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1173026013277 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1173026013278 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1173026013279 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1173026013280 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1173026013281 putative ADP-binding pocket [chemical binding]; other site 1173026013282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026013283 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026013284 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026013285 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026013286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026013287 Walker A/P-loop; other site 1173026013288 ATP binding site [chemical binding]; other site 1173026013289 Q-loop/lid; other site 1173026013290 ABC transporter signature motif; other site 1173026013291 Walker B; other site 1173026013292 D-loop; other site 1173026013293 H-loop/switch region; other site 1173026013294 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026013295 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173026013296 substrate binding site [chemical binding]; other site 1173026013297 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1173026013298 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026013299 substrate binding site [chemical binding]; other site 1173026013300 S-layer homology domain; Region: SLH; pfam00395 1173026013301 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026013302 EamA-like transporter family; Region: EamA; pfam00892 1173026013303 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173026013304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026013305 dimerization interface [polypeptide binding]; other site 1173026013306 putative DNA binding site [nucleotide binding]; other site 1173026013307 putative Zn2+ binding site [ion binding]; other site 1173026013308 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1173026013309 generic binding surface II; other site 1173026013310 generic binding surface I; other site 1173026013311 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1173026013312 putative catalytic site [active] 1173026013313 putative metal binding site [ion binding]; other site 1173026013314 putative phosphate binding site [ion binding]; other site 1173026013315 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1173026013316 putative heme binding pocket [chemical binding]; other site 1173026013317 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1173026013318 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1173026013319 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1173026013320 putative active site [active] 1173026013321 putative substrate binding site [chemical binding]; other site 1173026013322 putative cosubstrate binding site; other site 1173026013323 catalytic site [active] 1173026013324 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1173026013325 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 1173026013326 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1173026013327 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1173026013328 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026013329 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1173026013330 Walker A/P-loop; other site 1173026013331 ATP binding site [chemical binding]; other site 1173026013332 Q-loop/lid; other site 1173026013333 ABC transporter signature motif; other site 1173026013334 Walker B; other site 1173026013335 D-loop; other site 1173026013336 H-loop/switch region; other site 1173026013337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026013338 S-adenosylmethionine binding site [chemical binding]; other site 1173026013339 HEAT repeats; Region: HEAT_2; pfam13646 1173026013340 HEAT repeats; Region: HEAT_2; pfam13646 1173026013341 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173026013342 HEAT repeats; Region: HEAT_2; pfam13646 1173026013343 CpeS-like protein; Region: CpeS; pfam09367 1173026013344 proton extrusion protein PcxA; Provisional; Region: PRK02507 1173026013345 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1173026013346 homotrimer interface [polypeptide binding]; other site 1173026013347 Walker A motif; other site 1173026013348 GTP binding site [chemical binding]; other site 1173026013349 Walker B motif; other site 1173026013350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026013351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1173026013352 active site 1173026013353 phosphorylation site [posttranslational modification] 1173026013354 intermolecular recognition site; other site 1173026013355 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1173026013356 CHASE2 domain; Region: CHASE2; pfam05226 1173026013357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173026013358 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 1173026013359 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026013360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013361 binding surface 1173026013362 TPR motif; other site 1173026013363 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026013364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 1173026013365 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173026013366 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173026013367 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1173026013368 active site 1173026013369 catalytic residues [active] 1173026013370 PrcB C-terminal; Region: PrcB_C; pfam14343 1173026013371 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1173026013372 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1173026013373 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1173026013374 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1173026013375 Surface antigen; Region: Bac_surface_Ag; pfam01103 1173026013376 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1173026013377 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1173026013378 catalytic triad [active] 1173026013379 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173026013380 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173026013381 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1173026013382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026013383 Walker A/P-loop; other site 1173026013384 ATP binding site [chemical binding]; other site 1173026013385 Q-loop/lid; other site 1173026013386 ABC transporter signature motif; other site 1173026013387 Walker B; other site 1173026013388 D-loop; other site 1173026013389 H-loop/switch region; other site 1173026013390 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1173026013391 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173026013392 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1173026013393 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1173026013394 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1173026013395 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1173026013396 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173026013397 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173026013398 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1173026013399 D-pathway; other site 1173026013400 Putative ubiquinol binding site [chemical binding]; other site 1173026013401 Low-spin heme (heme b) binding site [chemical binding]; other site 1173026013402 Putative water exit pathway; other site 1173026013403 Binuclear center (heme o3/CuB) [ion binding]; other site 1173026013404 K-pathway; other site 1173026013405 Putative proton exit pathway; other site 1173026013406 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173026013407 Subunit I/III interface [polypeptide binding]; other site 1173026013408 PAS fold; Region: PAS; pfam00989 1173026013409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026013410 putative active site [active] 1173026013411 heme pocket [chemical binding]; other site 1173026013412 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026013413 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1173026013414 ligand binding site [chemical binding]; other site 1173026013415 flexible hinge region; other site 1173026013416 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1173026013417 putative switch regulator; other site 1173026013418 non-specific DNA interactions [nucleotide binding]; other site 1173026013419 DNA binding site [nucleotide binding] 1173026013420 sequence specific DNA binding site [nucleotide binding]; other site 1173026013421 putative cAMP binding site [chemical binding]; other site 1173026013422 light-harvesting-like protein 3; Provisional; Region: PLN00014 1173026013423 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1173026013424 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1173026013425 hexamer interface [polypeptide binding]; other site 1173026013426 ligand binding site [chemical binding]; other site 1173026013427 putative active site [active] 1173026013428 NAD(P) binding site [chemical binding]; other site 1173026013429 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1173026013430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1173026013431 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1173026013432 EamA-like transporter family; Region: EamA; pfam00892 1173026013433 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026013434 TrkA-N domain; Region: TrkA_N; pfam02254 1173026013435 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1173026013436 TrkA-N domain; Region: TrkA_N; pfam02254 1173026013437 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 1173026013438 active site 1173026013439 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1173026013440 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1173026013441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1173026013442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1173026013443 active site 1173026013444 metal binding site [ion binding]; metal-binding site 1173026013445 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1173026013446 Pirin-related protein [General function prediction only]; Region: COG1741 1173026013447 Pirin; Region: Pirin; pfam02678 1173026013448 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1173026013449 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 1173026013450 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1173026013451 Double zinc ribbon; Region: DZR; pfam12773 1173026013452 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 1173026013453 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1173026013454 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1173026013455 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1173026013456 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173026013457 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173026013458 metal-binding site [ion binding] 1173026013459 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026013460 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026013461 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1173026013462 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1173026013463 phosphopeptide binding site; other site 1173026013464 thymidylate kinase; Validated; Region: tmk; PRK00698 1173026013465 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1173026013466 TMP-binding site; other site 1173026013467 ATP-binding site [chemical binding]; other site 1173026013468 DNA polymerase III subunit delta'; Validated; Region: PRK07399 1173026013469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1173026013470 Walker A motif; other site 1173026013471 ATP binding site [chemical binding]; other site 1173026013472 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 1173026013473 Stage II sporulation protein; Region: SpoIID; pfam08486 1173026013474 ribonuclease Z; Region: RNase_Z; TIGR02651 1173026013475 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173026013476 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173026013477 cobyric acid synthase; Provisional; Region: PRK00784 1173026013478 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1173026013479 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1173026013480 catalytic triad [active] 1173026013481 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1173026013482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1173026013483 catalytic loop [active] 1173026013484 iron binding site [ion binding]; other site 1173026013485 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1173026013486 putative hydrophobic ligand binding site [chemical binding]; other site 1173026013487 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1173026013488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013489 TPR motif; other site 1173026013490 binding surface 1173026013491 Oleosin; Region: Oleosin; pfam01277 1173026013492 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1173026013493 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1173026013494 putative NAD(P) binding site [chemical binding]; other site 1173026013495 putative active site [active] 1173026013496 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1173026013497 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1173026013498 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1173026013499 active site residue [active] 1173026013500 short chain dehydrogenase; Provisional; Region: PRK07109 1173026013501 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1173026013502 putative NAD(P) binding site [chemical binding]; other site 1173026013503 active site 1173026013504 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026013505 DevC protein; Region: devC; TIGR01185 1173026013506 FtsX-like permease family; Region: FtsX; pfam02687 1173026013507 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1173026013508 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1173026013509 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1173026013510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026013511 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1173026013512 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1173026013513 Cupin-like domain; Region: Cupin_8; pfam13621 1173026013514 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1173026013515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026013516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026013517 putative substrate translocation pore; other site 1173026013518 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173026013519 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173026013520 Walker A/P-loop; other site 1173026013521 ATP binding site [chemical binding]; other site 1173026013522 Q-loop/lid; other site 1173026013523 ABC transporter signature motif; other site 1173026013524 Walker B; other site 1173026013525 D-loop; other site 1173026013526 H-loop/switch region; other site 1173026013527 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1173026013528 cobalt transport protein CbiM; Validated; Region: PRK06265 1173026013529 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1173026013530 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1173026013531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026013532 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1173026013533 Walker A/P-loop; other site 1173026013534 ATP binding site [chemical binding]; other site 1173026013535 Q-loop/lid; other site 1173026013536 ABC transporter signature motif; other site 1173026013537 Walker B; other site 1173026013538 D-loop; other site 1173026013539 H-loop/switch region; other site 1173026013540 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173026013541 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173026013542 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1173026013543 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1173026013544 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026013545 putative active site [active] 1173026013546 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1173026013547 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1173026013548 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1173026013549 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1173026013550 oligomeric interface; other site 1173026013551 putative active site [active] 1173026013552 homodimer interface [polypeptide binding]; other site 1173026013553 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1173026013554 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1173026013555 [2Fe-2S] cluster binding site [ion binding]; other site 1173026013556 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173026013557 hydrophobic ligand binding site; other site 1173026013558 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173026013559 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1173026013560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026013561 catalytic residue [active] 1173026013562 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1173026013563 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1173026013564 putative NADP binding site [chemical binding]; other site 1173026013565 putative substrate binding site [chemical binding]; other site 1173026013566 active site 1173026013567 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026013568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1173026013569 Walker A/P-loop; other site 1173026013570 ATP binding site [chemical binding]; other site 1173026013571 Q-loop/lid; other site 1173026013572 ABC transporter signature motif; other site 1173026013573 Walker B; other site 1173026013574 D-loop; other site 1173026013575 H-loop/switch region; other site 1173026013576 Clp protease ATP binding subunit; Region: clpC; CHL00095 1173026013577 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026013578 Clp amino terminal domain; Region: Clp_N; pfam02861 1173026013579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026013580 Walker A motif; other site 1173026013581 ATP binding site [chemical binding]; other site 1173026013582 Walker B motif; other site 1173026013583 arginine finger; other site 1173026013584 UvrB/uvrC motif; Region: UVR; pfam02151 1173026013585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026013586 Walker A motif; other site 1173026013587 ATP binding site [chemical binding]; other site 1173026013588 Walker B motif; other site 1173026013589 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1173026013590 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1173026013591 pheophytin binding site; other site 1173026013592 chlorophyll binding site; other site 1173026013593 quinone binding site; other site 1173026013594 Fe binding site [ion binding]; other site 1173026013595 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1173026013596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026013597 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1173026013598 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1173026013599 putative dimer interface [polypeptide binding]; other site 1173026013600 Inward rectifier potassium channel; Region: IRK; pfam01007 1173026013601 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1173026013602 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1173026013603 S-layer homology domain; Region: SLH; pfam00395 1173026013604 S-layer homology domain; Region: SLH; pfam00395 1173026013605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173026013606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026013607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173026013608 dimerization interface [polypeptide binding]; other site 1173026013609 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1173026013610 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1173026013611 Walker A/P-loop; other site 1173026013612 ATP binding site [chemical binding]; other site 1173026013613 Q-loop/lid; other site 1173026013614 ABC transporter signature motif; other site 1173026013615 Walker B; other site 1173026013616 D-loop; other site 1173026013617 H-loop/switch region; other site 1173026013618 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1173026013619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1173026013620 ABC-ATPase subunit interface; other site 1173026013621 dimer interface [polypeptide binding]; other site 1173026013622 putative PBP binding regions; other site 1173026013623 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1173026013624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026013625 acyl-activating enzyme (AAE) consensus motif; other site 1173026013626 active site 1173026013627 AMP binding site [chemical binding]; other site 1173026013628 CoA binding site [chemical binding]; other site 1173026013629 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173026013630 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026013631 active site 1173026013632 ATP binding site [chemical binding]; other site 1173026013633 substrate binding site [chemical binding]; other site 1173026013634 activation loop (A-loop); other site 1173026013635 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1173026013636 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026013637 active site 1173026013638 ATP binding site [chemical binding]; other site 1173026013639 substrate binding site [chemical binding]; other site 1173026013640 activation loop (A-loop); other site 1173026013641 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1173026013642 Phosphoglycerate kinase; Region: PGK; pfam00162 1173026013643 substrate binding site [chemical binding]; other site 1173026013644 hinge regions; other site 1173026013645 ADP binding site [chemical binding]; other site 1173026013646 catalytic site [active] 1173026013647 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026013648 Ligand Binding Site [chemical binding]; other site 1173026013649 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1173026013650 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1173026013651 GTP/Mg2+ binding site [chemical binding]; other site 1173026013652 G4 box; other site 1173026013653 G5 box; other site 1173026013654 G1 box; other site 1173026013655 Switch I region; other site 1173026013656 G2 box; other site 1173026013657 G3 box; other site 1173026013658 Switch II region; other site 1173026013659 XisH protein; Region: XisH; pfam08814 1173026013660 XisI protein; Region: XisI; pfam08869 1173026013661 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1173026013662 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026013663 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026013664 siderophore binding site; other site 1173026013665 AMIN domain; Region: AMIN; pfam11741 1173026013666 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026013667 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026013668 N-terminal plug; other site 1173026013669 ligand-binding site [chemical binding]; other site 1173026013670 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026013671 putative active site [active] 1173026013672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026013673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026013674 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1173026013675 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1173026013676 trimer interface [polypeptide binding]; other site 1173026013677 active site 1173026013678 proton extrusion protein PcxA; Provisional; Region: PRK02507 1173026013679 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1173026013680 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 1173026013681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026013682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026013683 dimer interface [polypeptide binding]; other site 1173026013684 phosphorylation site [posttranslational modification] 1173026013685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026013686 ATP binding site [chemical binding]; other site 1173026013687 Mg2+ binding site [ion binding]; other site 1173026013688 G-X-G motif; other site 1173026013689 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026013690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026013691 active site 1173026013692 phosphorylation site [posttranslational modification] 1173026013693 intermolecular recognition site; other site 1173026013694 dimerization interface [polypeptide binding]; other site 1173026013695 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026013696 DNA binding site [nucleotide binding] 1173026013697 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026013698 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1173026013699 putative metal binding site; other site 1173026013700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013701 TPR motif; other site 1173026013702 binding surface 1173026013703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013704 binding surface 1173026013705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1173026013706 TPR motif; other site 1173026013707 TPR repeat; Region: TPR_11; pfam13414 1173026013708 TPR repeat; Region: TPR_11; pfam13414 1173026013709 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1173026013710 Fasciclin domain; Region: Fasciclin; pfam02469 1173026013711 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173026013712 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1173026013713 C-terminal domain interface [polypeptide binding]; other site 1173026013714 GSH binding site (G-site) [chemical binding]; other site 1173026013715 dimer interface [polypeptide binding]; other site 1173026013716 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1173026013717 N-terminal domain interface [polypeptide binding]; other site 1173026013718 HAS barrel domain; Region: HAS-barrel; pfam09378 1173026013719 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1173026013720 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173026013721 RNA polymerase sigma factor; Validated; Region: PRK05949 1173026013722 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173026013723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026013724 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026013725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026013726 DNA binding residues [nucleotide binding] 1173026013727 Condensation domain; Region: Condensation; pfam00668 1173026013728 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026013729 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026013730 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026013731 acyl-activating enzyme (AAE) consensus motif; other site 1173026013732 AMP binding site [chemical binding]; other site 1173026013733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026013734 S-adenosylmethionine binding site [chemical binding]; other site 1173026013735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026013736 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026013737 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1173026013738 Condensation domain; Region: Condensation; pfam00668 1173026013739 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026013740 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026013741 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1173026013742 acyl-activating enzyme (AAE) consensus motif; other site 1173026013743 AMP binding site [chemical binding]; other site 1173026013744 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026013745 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026013746 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1173026013747 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026013748 GAF domain; Region: GAF_3; pfam13492 1173026013749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026013750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026013751 dimer interface [polypeptide binding]; other site 1173026013752 phosphorylation site [posttranslational modification] 1173026013753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026013754 ATP binding site [chemical binding]; other site 1173026013755 Mg2+ binding site [ion binding]; other site 1173026013756 G-X-G motif; other site 1173026013757 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026013758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026013759 active site 1173026013760 phosphorylation site [posttranslational modification] 1173026013761 intermolecular recognition site; other site 1173026013762 dimerization interface [polypeptide binding]; other site 1173026013763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026013764 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026013765 putative active site [active] 1173026013766 heme pocket [chemical binding]; other site 1173026013767 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026013768 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1173026013769 putative active site [active] 1173026013770 heme pocket [chemical binding]; other site 1173026013771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026013772 putative active site [active] 1173026013773 heme pocket [chemical binding]; other site 1173026013774 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026013775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026013776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026013777 dimer interface [polypeptide binding]; other site 1173026013778 phosphorylation site [posttranslational modification] 1173026013779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026013780 ATP binding site [chemical binding]; other site 1173026013781 Mg2+ binding site [ion binding]; other site 1173026013782 G-X-G motif; other site 1173026013783 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026013784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026013785 active site 1173026013786 phosphorylation site [posttranslational modification] 1173026013787 intermolecular recognition site; other site 1173026013788 dimerization interface [polypeptide binding]; other site 1173026013789 putative carbohydrate kinase; Provisional; Region: PRK10565 1173026013790 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1173026013791 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1173026013792 putative substrate binding site [chemical binding]; other site 1173026013793 putative ATP binding site [chemical binding]; other site 1173026013794 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1173026013795 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026013796 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1173026013797 PAS domain S-box; Region: sensory_box; TIGR00229 1173026013798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026013799 putative active site [active] 1173026013800 heme pocket [chemical binding]; other site 1173026013801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026013802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026013803 metal binding site [ion binding]; metal-binding site 1173026013804 active site 1173026013805 I-site; other site 1173026013806 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1173026013807 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1173026013808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026013809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026013810 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1173026013811 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1173026013812 tetramer interface [polypeptide binding]; other site 1173026013813 heme binding pocket [chemical binding]; other site 1173026013814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1173026013815 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1173026013816 flavodoxin FldA; Validated; Region: PRK09267 1173026013817 Photosystem II protein; Region: PSII; cl08223 1173026013818 Photosystem II protein; Region: PSII; cl08223 1173026013819 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 1173026013820 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 1173026013821 Thf1-like protein; Reviewed; Region: PRK13266 1173026013822 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 1173026013823 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1173026013824 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173026013825 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1173026013826 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026013827 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026013828 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026013829 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1173026013830 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173026013831 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173026013832 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173026013833 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173026013834 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 1173026013835 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 1173026013836 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 1173026013837 phycocyanin beta subunit; Reviewed; Region: cpcB; CHL00171 1173026013838 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1173026013839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1173026013840 RNA binding surface [nucleotide binding]; other site 1173026013841 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1173026013842 active site 1173026013843 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1173026013844 Phosphotransferase enzyme family; Region: APH; pfam01636 1173026013845 putative active site [active] 1173026013846 putative substrate binding site [chemical binding]; other site 1173026013847 ATP binding site [chemical binding]; other site 1173026013848 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173026013849 active site 1173026013850 SAM binding site [chemical binding]; other site 1173026013851 homodimer interface [polypeptide binding]; other site 1173026013852 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1173026013853 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1173026013854 putative active site [active] 1173026013855 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1173026013856 putative active site [active] 1173026013857 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1173026013858 Ferritin-like domain; Region: Ferritin; pfam00210 1173026013859 dimanganese center [ion binding]; other site 1173026013860 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026013861 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026013862 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026013863 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1173026013864 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1173026013865 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1173026013866 methionine aminopeptidase; Provisional; Region: PRK12318 1173026013867 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1173026013868 active site 1173026013869 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1173026013870 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1173026013871 trimer interface [polypeptide binding]; other site 1173026013872 active site 1173026013873 substrate binding site [chemical binding]; other site 1173026013874 CoA binding site [chemical binding]; other site 1173026013875 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1173026013876 Amidase; Region: Amidase; pfam01425 1173026013877 beta-galactosidase; Region: BGL; TIGR03356 1173026013878 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1173026013879 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173026013880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026013881 motif II; other site 1173026013882 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026013883 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 1173026013884 ligand binding site [chemical binding]; other site 1173026013885 flexible hinge region; other site 1173026013886 Ycf27; Reviewed; Region: orf27; CHL00148 1173026013887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026013888 active site 1173026013889 phosphorylation site [posttranslational modification] 1173026013890 intermolecular recognition site; other site 1173026013891 dimerization interface [polypeptide binding]; other site 1173026013892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026013893 DNA binding site [nucleotide binding] 1173026013894 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1173026013895 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173026013896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026013897 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026013898 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1173026013899 apolar tunnel; other site 1173026013900 heme binding site [chemical binding]; other site 1173026013901 dimerization interface [polypeptide binding]; other site 1173026013902 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1173026013903 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026013904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026013905 S-adenosylmethionine binding site [chemical binding]; other site 1173026013906 WYL domain; Region: WYL; pfam13280 1173026013907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1173026013908 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 1173026013909 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 1173026013910 CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174 1173026013911 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869 1173026013912 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 1173026013913 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 1173026013914 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1173026013915 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1173026013916 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1173026013917 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1173026013918 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1173026013919 YwiC-like protein; Region: YwiC; pfam14256 1173026013920 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1173026013921 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 1173026013922 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1173026013923 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 1173026013924 putative active site [active] 1173026013925 catalytic site [active] 1173026013926 NifU-like domain; Region: NifU; pfam01106 1173026013927 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 1173026013928 S-layer homology domain; Region: SLH; pfam00395 1173026013929 adaptive-response sensory kinase; Validated; Region: PRK09303 1173026013930 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1173026013931 tetramer interface [polypeptide binding]; other site 1173026013932 dimer interface [polypeptide binding]; other site 1173026013933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026013934 dimer interface [polypeptide binding]; other site 1173026013935 phosphorylation site [posttranslational modification] 1173026013936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026013937 ATP binding site [chemical binding]; other site 1173026013938 Mg2+ binding site [ion binding]; other site 1173026013939 G-X-G motif; other site 1173026013940 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1173026013941 active site 1173026013942 8-oxo-dGMP binding site [chemical binding]; other site 1173026013943 nudix motif; other site 1173026013944 metal binding site [ion binding]; metal-binding site 1173026013945 Protein of unknown function (DUF760); Region: DUF760; pfam05542 1173026013946 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 1173026013947 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1173026013948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026013949 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1173026013950 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026013951 DNA binding residues [nucleotide binding] 1173026013952 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1173026013953 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173026013954 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1173026013955 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1173026013956 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1173026013957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1173026013958 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1173026013959 IMP binding site; other site 1173026013960 dimer interface [polypeptide binding]; other site 1173026013961 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1173026013962 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1173026013963 dimerization interface [polypeptide binding]; other site 1173026013964 DPS ferroxidase diiron center [ion binding]; other site 1173026013965 ion pore; other site 1173026013966 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1173026013967 dimer interface [polypeptide binding]; other site 1173026013968 [2Fe-2S] cluster binding site [ion binding]; other site 1173026013969 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1173026013970 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026013971 ligand binding site [chemical binding]; other site 1173026013972 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1173026013973 flexible hinge region; other site 1173026013974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026013975 Walker A motif; other site 1173026013976 ATP binding site [chemical binding]; other site 1173026013977 Walker B motif; other site 1173026013978 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 1173026013979 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173026013980 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1173026013981 CAAX protease self-immunity; Region: Abi; pfam02517 1173026013982 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173026013983 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026013984 Pirin-related protein [General function prediction only]; Region: COG1741 1173026013985 Pirin; Region: Pirin; pfam02678 1173026013986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1173026013987 MarR family; Region: MarR; pfam01047 1173026013988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013989 binding surface 1173026013990 TPR repeat; Region: TPR_11; pfam13414 1173026013991 TPR motif; other site 1173026013992 TPR repeat; Region: TPR_11; pfam13414 1173026013993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013994 binding surface 1173026013995 TPR motif; other site 1173026013996 TPR repeat; Region: TPR_11; pfam13414 1173026013997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026013998 binding surface 1173026013999 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026014000 TPR motif; other site 1173026014001 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1173026014002 elongation factor G; Reviewed; Region: PRK12740 1173026014003 G1 box; other site 1173026014004 putative GEF interaction site [polypeptide binding]; other site 1173026014005 GTP/Mg2+ binding site [chemical binding]; other site 1173026014006 Switch I region; other site 1173026014007 G2 box; other site 1173026014008 G3 box; other site 1173026014009 Switch II region; other site 1173026014010 G4 box; other site 1173026014011 G5 box; other site 1173026014012 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1173026014013 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1173026014014 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1173026014015 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1173026014016 C-terminal peptidase (prc); Region: prc; TIGR00225 1173026014017 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1173026014018 protein binding site [polypeptide binding]; other site 1173026014019 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1173026014020 Catalytic dyad [active] 1173026014021 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1173026014022 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173026014023 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1173026014024 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173026014025 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173026014026 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1173026014027 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1173026014028 protein-splicing catalytic site; other site 1173026014029 thioester formation/cholesterol transfer; other site 1173026014030 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1173026014031 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1173026014032 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1173026014033 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 1173026014034 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1173026014035 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1173026014036 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1173026014037 trimer interface [polypeptide binding]; other site 1173026014038 active site 1173026014039 substrate binding site [chemical binding]; other site 1173026014040 CoA binding site [chemical binding]; other site 1173026014041 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1173026014042 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1173026014043 purine monophosphate binding site [chemical binding]; other site 1173026014044 dimer interface [polypeptide binding]; other site 1173026014045 putative catalytic residues [active] 1173026014046 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1173026014047 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1173026014048 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014049 putative active site [active] 1173026014050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026014051 Coenzyme A binding pocket [chemical binding]; other site 1173026014052 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014053 putative active site [active] 1173026014054 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1173026014055 active site 1173026014056 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1173026014057 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1173026014058 HIGH motif; other site 1173026014059 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1173026014060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1173026014061 active site 1173026014062 KMSKS motif; other site 1173026014063 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1173026014064 tRNA binding surface [nucleotide binding]; other site 1173026014065 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1173026014066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1173026014067 metal binding site [ion binding]; metal-binding site 1173026014068 active site 1173026014069 I-site; other site 1173026014070 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014071 putative active site [active] 1173026014072 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1173026014073 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1173026014074 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1173026014075 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1173026014076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1173026014077 Ligand Binding Site [chemical binding]; other site 1173026014078 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 1173026014079 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1173026014080 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1173026014081 HEAT repeats; Region: HEAT_2; pfam13646 1173026014082 HEAT repeats; Region: HEAT_2; pfam13646 1173026014083 HEAT repeats; Region: HEAT_2; pfam13646 1173026014084 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1173026014085 FOG: CBS domain [General function prediction only]; Region: COG0517 1173026014086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1173026014087 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1173026014088 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1173026014089 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 1173026014090 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026014091 GAF domain; Region: GAF_3; pfam13492 1173026014092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026014093 dimer interface [polypeptide binding]; other site 1173026014094 phosphorylation site [posttranslational modification] 1173026014095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026014096 ATP binding site [chemical binding]; other site 1173026014097 Mg2+ binding site [ion binding]; other site 1173026014098 G-X-G motif; other site 1173026014099 GTP-binding protein LepA; Provisional; Region: PRK05433 1173026014100 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1173026014101 G1 box; other site 1173026014102 putative GEF interaction site [polypeptide binding]; other site 1173026014103 GTP/Mg2+ binding site [chemical binding]; other site 1173026014104 Switch I region; other site 1173026014105 G2 box; other site 1173026014106 G3 box; other site 1173026014107 Switch II region; other site 1173026014108 G4 box; other site 1173026014109 G5 box; other site 1173026014110 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1173026014111 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1173026014112 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1173026014113 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014114 putative active site [active] 1173026014115 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026014116 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026014117 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1173026014118 Walker A/P-loop; other site 1173026014119 ATP binding site [chemical binding]; other site 1173026014120 Q-loop/lid; other site 1173026014121 ABC transporter signature motif; other site 1173026014122 Walker B; other site 1173026014123 D-loop; other site 1173026014124 H-loop/switch region; other site 1173026014125 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1173026014126 putative dimer interface [polypeptide binding]; other site 1173026014127 putative [2Fe-2S] cluster binding site [ion binding]; other site 1173026014128 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026014129 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026014130 siderophore binding site; other site 1173026014131 AMIN domain; Region: AMIN; pfam11741 1173026014132 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026014133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026014134 N-terminal plug; other site 1173026014135 ligand-binding site [chemical binding]; other site 1173026014136 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014137 putative active site [active] 1173026014138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026014139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026014140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1173026014141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026014142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026014143 Walker A/P-loop; other site 1173026014144 ATP binding site [chemical binding]; other site 1173026014145 Q-loop/lid; other site 1173026014146 ABC transporter signature motif; other site 1173026014147 Walker B; other site 1173026014148 D-loop; other site 1173026014149 H-loop/switch region; other site 1173026014150 DNA photolyase; Region: DNA_photolyase; pfam00875 1173026014151 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1173026014152 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173026014153 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1173026014154 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1173026014155 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173026014156 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1173026014157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026014158 catalytic residue [active] 1173026014159 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1173026014160 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1173026014161 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 1173026014162 putative heme binding site [chemical binding]; other site 1173026014163 putative substrate binding site [chemical binding]; other site 1173026014164 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1173026014165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173026014166 active site 1173026014167 dimer interface [polypeptide binding]; other site 1173026014168 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1173026014169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1173026014170 active site 1173026014171 catalytic tetrad [active] 1173026014172 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1173026014173 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1173026014174 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1173026014175 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1173026014176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026014177 S-adenosylmethionine binding site [chemical binding]; other site 1173026014178 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1173026014179 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1173026014180 Walker A/P-loop; other site 1173026014181 ATP binding site [chemical binding]; other site 1173026014182 Q-loop/lid; other site 1173026014183 ABC transporter signature motif; other site 1173026014184 Walker B; other site 1173026014185 D-loop; other site 1173026014186 H-loop/switch region; other site 1173026014187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026014188 TPR motif; other site 1173026014189 binding surface 1173026014190 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 1173026014191 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 1173026014192 nudix motif; other site 1173026014193 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 1173026014194 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1173026014195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1173026014196 active site 1173026014197 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1173026014198 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1173026014199 active site 1173026014200 ATP binding site [chemical binding]; other site 1173026014201 substrate binding site [chemical binding]; other site 1173026014202 activation loop (A-loop); other site 1173026014203 AAA domain; Region: AAA_26; pfam13500 1173026014204 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1173026014205 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014206 putative active site [active] 1173026014207 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173026014208 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1173026014209 metal binding site [ion binding]; metal-binding site 1173026014210 dimer interface [polypeptide binding]; other site 1173026014211 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1173026014212 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1173026014213 C-terminal domain interface [polypeptide binding]; other site 1173026014214 GSH binding site (G-site) [chemical binding]; other site 1173026014215 dimer interface [polypeptide binding]; other site 1173026014216 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1173026014217 N-terminal domain interface [polypeptide binding]; other site 1173026014218 putative dimer interface [polypeptide binding]; other site 1173026014219 active site 1173026014220 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1173026014221 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 1173026014222 putative ligand binding site [chemical binding]; other site 1173026014223 putative NAD binding site [chemical binding]; other site 1173026014224 catalytic site [active] 1173026014225 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173026014226 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1173026014227 Protein of unknown function DUF262; Region: DUF262; pfam03235 1173026014228 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1173026014229 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1173026014230 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1173026014231 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 1173026014232 dimerization interface [polypeptide binding]; other site 1173026014233 putative ATP binding site [chemical binding]; other site 1173026014234 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1173026014235 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1173026014236 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026014237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026014238 dimer interface [polypeptide binding]; other site 1173026014239 conserved gate region; other site 1173026014240 putative PBP binding loops; other site 1173026014241 ABC-ATPase subunit interface; other site 1173026014242 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173026014243 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026014244 Walker A/P-loop; other site 1173026014245 ATP binding site [chemical binding]; other site 1173026014246 Q-loop/lid; other site 1173026014247 ABC transporter signature motif; other site 1173026014248 Walker B; other site 1173026014249 D-loop; other site 1173026014250 H-loop/switch region; other site 1173026014251 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1173026014252 heme-binding site [chemical binding]; other site 1173026014253 hypothetical protein; Provisional; Region: PRK06847 1173026014254 hypothetical protein; Provisional; Region: PRK07236 1173026014255 xanthine permease; Region: pbuX; TIGR03173 1173026014256 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1173026014257 active site 1173026014258 homotetramer interface [polypeptide binding]; other site 1173026014259 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1173026014260 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1173026014261 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1173026014262 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 1173026014263 putative hexamer interface [polypeptide binding]; other site 1173026014264 putative hexagonal pore; other site 1173026014265 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 1173026014266 Hexamer interface [polypeptide binding]; other site 1173026014267 Hexagonal pore residue; other site 1173026014268 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026014269 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014270 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014271 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014272 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014273 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014274 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1173026014275 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026014276 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1173026014277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026014278 motif II; other site 1173026014279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026014280 S-adenosylmethionine binding site [chemical binding]; other site 1173026014281 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1173026014282 FAD binding domain; Region: FAD_binding_4; pfam01565 1173026014283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026014284 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026014285 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026014286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026014287 putative active site [active] 1173026014288 heme pocket [chemical binding]; other site 1173026014289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026014290 dimer interface [polypeptide binding]; other site 1173026014291 phosphorylation site [posttranslational modification] 1173026014292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026014293 ATP binding site [chemical binding]; other site 1173026014294 Mg2+ binding site [ion binding]; other site 1173026014295 G-X-G motif; other site 1173026014296 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026014297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026014298 active site 1173026014299 phosphorylation site [posttranslational modification] 1173026014300 intermolecular recognition site; other site 1173026014301 dimerization interface [polypeptide binding]; other site 1173026014302 PAS fold; Region: PAS_4; pfam08448 1173026014303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026014304 putative active site [active] 1173026014305 heme pocket [chemical binding]; other site 1173026014306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026014307 PAS fold; Region: PAS_3; pfam08447 1173026014308 putative active site [active] 1173026014309 heme pocket [chemical binding]; other site 1173026014310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1173026014311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026014312 dimer interface [polypeptide binding]; other site 1173026014313 phosphorylation site [posttranslational modification] 1173026014314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026014315 ATP binding site [chemical binding]; other site 1173026014316 Mg2+ binding site [ion binding]; other site 1173026014317 G-X-G motif; other site 1173026014318 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026014319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026014320 active site 1173026014321 phosphorylation site [posttranslational modification] 1173026014322 intermolecular recognition site; other site 1173026014323 dimerization interface [polypeptide binding]; other site 1173026014324 Predicted membrane protein [Function unknown]; Region: COG3463 1173026014325 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1173026014326 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1173026014327 putative addiction module antidote; Region: doc_partner; TIGR02609 1173026014328 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1173026014329 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014330 putative active site [active] 1173026014331 dephospho-CoA kinase; Region: TIGR00152 1173026014332 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1173026014333 CoA-binding site [chemical binding]; other site 1173026014334 ATP-binding [chemical binding]; other site 1173026014335 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1173026014336 active site 1173026014337 SAM binding site [chemical binding]; other site 1173026014338 homodimer interface [polypeptide binding]; other site 1173026014339 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1173026014340 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1173026014341 active site 1173026014342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026014343 binding surface 1173026014344 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026014345 TPR motif; other site 1173026014346 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1173026014347 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 1173026014348 UbiA prenyltransferase family; Region: UbiA; pfam01040 1173026014349 tocopherol O-methyltransferase; Region: PLN02244 1173026014350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026014351 S-adenosylmethionine binding site [chemical binding]; other site 1173026014352 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1173026014353 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1173026014354 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1173026014355 TrkA-N domain; Region: TrkA_N; pfam02254 1173026014356 TrkA-C domain; Region: TrkA_C; pfam02080 1173026014357 Class I aldolases; Region: Aldolase_Class_I; cl17187 1173026014358 catalytic residue [active] 1173026014359 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173026014360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026014361 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1173026014362 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1173026014363 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 1173026014364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026014365 binding surface 1173026014366 TPR motif; other site 1173026014367 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1173026014368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026014369 binding surface 1173026014370 TPR motif; other site 1173026014371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026014372 binding surface 1173026014373 TPR motif; other site 1173026014374 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1173026014375 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1173026014376 hypothetical protein; Reviewed; Region: PRK12497 1173026014377 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026014378 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014380 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014381 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1173026014382 DNA primase; Validated; Region: dnaG; PRK05667 1173026014383 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1173026014384 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1173026014385 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1173026014386 active site 1173026014387 metal binding site [ion binding]; metal-binding site 1173026014388 interdomain interaction site; other site 1173026014389 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1173026014390 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1173026014391 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1173026014392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1173026014393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1173026014394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1173026014395 dimerization interface [polypeptide binding]; other site 1173026014396 EamA-like transporter family; Region: EamA; pfam00892 1173026014397 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1173026014398 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1173026014399 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1173026014400 Subunit I/III interface [polypeptide binding]; other site 1173026014401 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1173026014402 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1173026014403 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1173026014404 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1173026014405 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1173026014406 Predicted membrane protein [Function unknown]; Region: COG4244 1173026014407 Predicted membrane protein [Function unknown]; Region: COG4244 1173026014408 CP12 domain; Region: CP12; smart01093 1173026014409 hydrolase, alpha/beta fold family protein; Region: PLN02824 1173026014410 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1173026014411 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 1173026014412 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1173026014413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026014414 binding surface 1173026014415 TPR motif; other site 1173026014416 TPR repeat; Region: TPR_11; pfam13414 1173026014417 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1173026014418 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1173026014419 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1173026014420 Walker A/P-loop; other site 1173026014421 ATP binding site [chemical binding]; other site 1173026014422 Q-loop/lid; other site 1173026014423 ABC transporter signature motif; other site 1173026014424 Walker B; other site 1173026014425 D-loop; other site 1173026014426 H-loop/switch region; other site 1173026014427 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1173026014428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026014429 dimer interface [polypeptide binding]; other site 1173026014430 conserved gate region; other site 1173026014431 putative PBP binding loops; other site 1173026014432 ABC-ATPase subunit interface; other site 1173026014433 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1173026014434 FAD binding domain; Region: FAD_binding_4; pfam01565 1173026014435 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1173026014436 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1173026014437 putative active site [active] 1173026014438 adenylation catalytic residue [active] 1173026014439 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1173026014440 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1173026014441 2TM domain; Region: 2TM; pfam13239 1173026014442 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1173026014443 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026014444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026014445 active site 1173026014446 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1173026014447 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1173026014448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026014449 active site 1173026014450 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1173026014451 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1173026014452 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1173026014453 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1173026014454 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1173026014455 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 1173026014456 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1173026014457 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1173026014458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1173026014459 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1173026014460 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1173026014461 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1173026014462 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1173026014463 hydrophobic ligand binding site; other site 1173026014464 Putative cyclase; Region: Cyclase; pfam04199 1173026014465 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1173026014466 Cupin domain; Region: Cupin_2; pfam07883 1173026014467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026014468 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1173026014469 acyl-activating enzyme (AAE) consensus motif; other site 1173026014470 AMP binding site [chemical binding]; other site 1173026014471 active site 1173026014472 CoA binding site [chemical binding]; other site 1173026014473 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1173026014474 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1173026014475 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173026014476 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1173026014477 dimer interface [polypeptide binding]; other site 1173026014478 active site 1173026014479 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1173026014480 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1173026014481 dimer interface [polypeptide binding]; other site 1173026014482 active site 1173026014483 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1173026014484 FAD binding site [chemical binding]; other site 1173026014485 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1173026014486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026014487 Walker A/P-loop; other site 1173026014488 ATP binding site [chemical binding]; other site 1173026014489 Q-loop/lid; other site 1173026014490 ABC transporter signature motif; other site 1173026014491 Walker B; other site 1173026014492 D-loop; other site 1173026014493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1173026014494 binding surface 1173026014495 TPR motif; other site 1173026014496 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026014497 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014498 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014500 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1173026014501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026014502 active site 1173026014503 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1173026014504 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1173026014505 active site 1173026014506 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1173026014507 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1173026014508 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1173026014509 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1173026014510 FAD binding pocket [chemical binding]; other site 1173026014511 FAD binding motif [chemical binding]; other site 1173026014512 phosphate binding motif [ion binding]; other site 1173026014513 beta-alpha-beta structure motif; other site 1173026014514 NAD binding pocket [chemical binding]; other site 1173026014515 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 1173026014516 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026014517 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026014518 DevC protein; Region: devC; TIGR01185 1173026014519 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1173026014520 FtsX-like permease family; Region: FtsX; pfam02687 1173026014521 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1173026014522 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1173026014523 Walker A/P-loop; other site 1173026014524 ATP binding site [chemical binding]; other site 1173026014525 Q-loop/lid; other site 1173026014526 ABC transporter signature motif; other site 1173026014527 Walker B; other site 1173026014528 D-loop; other site 1173026014529 H-loop/switch region; other site 1173026014530 O-methyltransferase; Region: Methyltransf_2; pfam00891 1173026014531 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1173026014532 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1173026014533 O-methyltransferase; Region: Methyltransf_2; pfam00891 1173026014534 O-methyltransferase; Region: Methyltransf_2; pfam00891 1173026014535 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1173026014536 Cytochrome P450; Region: p450; cl12078 1173026014537 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1173026014538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1173026014539 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1173026014540 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1173026014541 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1173026014542 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1173026014543 septum-site determining protein; Validated; Region: minD; CHL00175 1173026014544 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1173026014545 Switch I; other site 1173026014546 Switch II; other site 1173026014547 cell division topological specificity factor MinE; Provisional; Region: PRK13988 1173026014548 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1173026014549 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1173026014550 PA/protease or protease-like domain interface [polypeptide binding]; other site 1173026014551 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1173026014552 Peptidase family M28; Region: Peptidase_M28; pfam04389 1173026014553 metal binding site [ion binding]; metal-binding site 1173026014554 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 1173026014555 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1173026014556 gamma subunit interface [polypeptide binding]; other site 1173026014557 epsilon subunit interface [polypeptide binding]; other site 1173026014558 LBP interface [polypeptide binding]; other site 1173026014559 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 1173026014560 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1173026014561 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1173026014562 alpha subunit interaction interface [polypeptide binding]; other site 1173026014563 Walker A motif; other site 1173026014564 ATP binding site [chemical binding]; other site 1173026014565 Walker B motif; other site 1173026014566 inhibitor binding site; inhibition site 1173026014567 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1173026014568 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026014569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014570 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026014571 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014572 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1173026014573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014576 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014577 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014578 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014579 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026014580 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1173026014581 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1173026014582 NAD binding site [chemical binding]; other site 1173026014583 dimer interface [polypeptide binding]; other site 1173026014584 substrate binding site [chemical binding]; other site 1173026014585 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1173026014586 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1173026014587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1173026014588 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1173026014589 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1173026014590 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1173026014591 putative active site pocket [active] 1173026014592 dimerization interface [polypeptide binding]; other site 1173026014593 putative catalytic residue [active] 1173026014594 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 1173026014595 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1173026014596 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1173026014597 metal binding site [ion binding]; metal-binding site 1173026014598 putative dimer interface [polypeptide binding]; other site 1173026014599 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1173026014600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026014601 Coenzyme A binding pocket [chemical binding]; other site 1173026014602 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1173026014603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1173026014604 Coenzyme A binding pocket [chemical binding]; other site 1173026014605 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173026014606 putative active site [active] 1173026014607 Protein of unknown function DUF104; Region: DUF104; cl11530 1173026014608 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1173026014609 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1173026014610 active site 1173026014611 catalytic residues [active] 1173026014612 metal binding site [ion binding]; metal-binding site 1173026014613 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1173026014614 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1173026014615 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1173026014616 protein binding site [polypeptide binding]; other site 1173026014617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026014618 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1173026014619 active site 1173026014620 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173026014621 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173026014622 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173026014623 putative NADP binding site [chemical binding]; other site 1173026014624 active site 1173026014625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014626 Condensation domain; Region: Condensation; pfam00668 1173026014627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014628 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026014629 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1173026014630 acyl-activating enzyme (AAE) consensus motif; other site 1173026014631 AMP binding site [chemical binding]; other site 1173026014632 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014633 Condensation domain; Region: Condensation; pfam00668 1173026014634 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014635 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1173026014636 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1173026014637 acyl-activating enzyme (AAE) consensus motif; other site 1173026014638 AMP binding site [chemical binding]; other site 1173026014639 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1173026014640 putative FMN binding site [chemical binding]; other site 1173026014641 NADPH bind site [chemical binding]; other site 1173026014642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026014643 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014644 Condensation domain; Region: Condensation; pfam00668 1173026014645 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014646 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026014647 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1173026014648 acyl-activating enzyme (AAE) consensus motif; other site 1173026014649 AMP binding site [chemical binding]; other site 1173026014650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014651 Condensation domain; Region: Condensation; pfam00668 1173026014652 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014653 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026014654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026014655 AMP-binding enzyme; Region: AMP-binding; pfam00501 1173026014656 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026014657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1173026014658 acyl-activating enzyme (AAE) consensus motif; other site 1173026014659 acyl-activating enzyme (AAE) consensus motif; other site 1173026014660 AMP binding site [chemical binding]; other site 1173026014661 active site 1173026014662 CoA binding site [chemical binding]; other site 1173026014663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014664 Condensation domain; Region: Condensation; pfam00668 1173026014665 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014666 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026014667 Condensation domain; Region: Condensation; pfam00668 1173026014668 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014669 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026014670 acyl-activating enzyme (AAE) consensus motif; other site 1173026014671 AMP binding site [chemical binding]; other site 1173026014672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014673 Condensation domain; Region: Condensation; pfam00668 1173026014674 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014675 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026014676 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026014677 acyl-activating enzyme (AAE) consensus motif; other site 1173026014678 AMP binding site [chemical binding]; other site 1173026014679 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014680 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1173026014681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1173026014682 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 1173026014683 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1173026014684 thioester reductase domain; Region: Thioester-redct; TIGR01746 1173026014685 putative NAD(P) binding site [chemical binding]; other site 1173026014686 active site 1173026014687 putative substrate binding site [chemical binding]; other site 1173026014688 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1173026014689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026014690 S-adenosylmethionine binding site [chemical binding]; other site 1173026014691 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1173026014692 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1173026014693 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1173026014694 catalytic residue [active] 1173026014695 MbtH-like protein; Region: MbtH; cl01279 1173026014696 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1173026014697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026014698 S-adenosylmethionine binding site [chemical binding]; other site 1173026014699 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026014700 active site 1173026014701 NTP binding site [chemical binding]; other site 1173026014702 metal binding triad [ion binding]; metal-binding site 1173026014703 antibiotic binding site [chemical binding]; other site 1173026014704 Protein of unknown function DUF86; Region: DUF86; cl01031 1173026014705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1173026014706 Protein of unknown function (DUF433); Region: DUF433; pfam04255 1173026014707 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014708 putative active site [active] 1173026014709 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1173026014710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026014711 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1173026014712 active site 1173026014713 intersubunit interface [polypeptide binding]; other site 1173026014714 catalytic residue [active] 1173026014715 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1173026014716 O-methyltransferase; Region: Methyltransf_2; pfam00891 1173026014717 flavodoxin FldA; Validated; Region: PRK09267 1173026014718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026014719 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1173026014720 putative substrate translocation pore; other site 1173026014721 Condensation domain; Region: Condensation; pfam00668 1173026014722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026014723 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1173026014724 acyl-activating enzyme (AAE) consensus motif; other site 1173026014725 AMP binding site [chemical binding]; other site 1173026014726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026014727 AAA-like domain; Region: AAA_10; pfam12846 1173026014728 Domain of unknown function DUF87; Region: DUF87; pfam01935 1173026014729 AAA-like domain; Region: AAA_10; pfam12846 1173026014730 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1173026014731 GIY-YIG motif/motif A; other site 1173026014732 active site 1173026014733 catalytic site [active] 1173026014734 metal binding site [ion binding]; metal-binding site 1173026014735 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1173026014736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026014737 NACHT domain; Region: NACHT; pfam05729 1173026014738 Walker A motif; other site 1173026014739 ATP binding site [chemical binding]; other site 1173026014740 Walker B motif; other site 1173026014741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026014742 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1173026014743 ParB-like nuclease domain; Region: ParB; smart00470 1173026014744 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173026014745 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026014746 P-loop; other site 1173026014747 Magnesium ion binding site [ion binding]; other site 1173026014748 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026014749 Magnesium ion binding site [ion binding]; other site 1173026014750 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1173026014751 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1173026014752 siderophore binding site; other site 1173026014753 AMIN domain; Region: AMIN; pfam11741 1173026014754 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1173026014755 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026014756 N-terminal plug; other site 1173026014757 ligand-binding site [chemical binding]; other site 1173026014758 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1173026014759 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1173026014760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1173026014761 Helix-turn-helix domain; Region: HTH_36; pfam13730 1173026014762 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1173026014763 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173026014764 ParB-like nuclease domain; Region: ParBc; cl02129 1173026014765 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1173026014766 T5orf172 domain; Region: T5orf172; cl17462 1173026014767 Predicted GTPase [General function prediction only]; Region: COG3596 1173026014768 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173026014769 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1173026014770 G1 box; other site 1173026014771 GTP/Mg2+ binding site [chemical binding]; other site 1173026014772 G2 box; other site 1173026014773 Switch I region; other site 1173026014774 G3 box; other site 1173026014775 Switch II region; other site 1173026014776 G4 box; other site 1173026014777 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026014778 active site 1173026014779 catalytic residues [active] 1173026014780 DNA binding site [nucleotide binding] 1173026014781 Int/Topo IB signature motif; other site 1173026014782 RES domain; Region: RES; pfam08808 1173026014783 PhoD-like phosphatase; Region: PhoD; pfam09423 1173026014784 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173026014785 putative active site [active] 1173026014786 putative metal binding site [ion binding]; other site 1173026014787 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1173026014788 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1173026014789 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1173026014790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026014791 dimer interface [polypeptide binding]; other site 1173026014792 conserved gate region; other site 1173026014793 putative PBP binding loops; other site 1173026014794 ABC-ATPase subunit interface; other site 1173026014795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1173026014796 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1173026014797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026014798 Walker A/P-loop; other site 1173026014799 ATP binding site [chemical binding]; other site 1173026014800 Q-loop/lid; other site 1173026014801 ABC transporter signature motif; other site 1173026014802 Walker B; other site 1173026014803 D-loop; other site 1173026014804 H-loop/switch region; other site 1173026014805 TOBE domain; Region: TOBE_2; pfam08402 1173026014806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1173026014807 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1173026014808 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1173026014809 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026014810 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1173026014811 active site 1173026014812 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1173026014813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1173026014814 motif II; other site 1173026014815 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1173026014816 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1173026014817 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1173026014818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1173026014819 DNA-binding site [nucleotide binding]; DNA binding site 1173026014820 UTRA domain; Region: UTRA; pfam07702 1173026014821 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1173026014822 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1173026014823 P-loop, Walker A motif; other site 1173026014824 Base recognition motif; other site 1173026014825 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1173026014826 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1173026014827 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1173026014828 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1173026014829 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1173026014830 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1173026014831 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1173026014832 amidase; Provisional; Region: PRK06828 1173026014833 Amidase; Region: Amidase; pfam01425 1173026014834 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1173026014835 GIY-YIG motif/motif A; other site 1173026014836 active site 1173026014837 catalytic site [active] 1173026014838 metal binding site [ion binding]; metal-binding site 1173026014839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026014840 salt bridge; other site 1173026014841 non-specific DNA binding site [nucleotide binding]; other site 1173026014842 sequence-specific DNA binding site [nucleotide binding]; other site 1173026014843 RES domain; Region: RES; pfam08808 1173026014844 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1173026014845 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1173026014846 DDE superfamily endonuclease; Region: DDE_5; cl17874 1173026014847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1173026014848 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1173026014849 putative ligand binding site [chemical binding]; other site 1173026014850 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1173026014851 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1173026014852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1173026014853 putative active site [active] 1173026014854 heme pocket [chemical binding]; other site 1173026014855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026014856 dimer interface [polypeptide binding]; other site 1173026014857 phosphorylation site [posttranslational modification] 1173026014858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026014859 ATP binding site [chemical binding]; other site 1173026014860 Mg2+ binding site [ion binding]; other site 1173026014861 G-X-G motif; other site 1173026014862 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1173026014863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026014864 active site 1173026014865 phosphorylation site [posttranslational modification] 1173026014866 intermolecular recognition site; other site 1173026014867 dimerization interface [polypeptide binding]; other site 1173026014868 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1173026014869 Response regulator receiver domain; Region: Response_reg; pfam00072 1173026014870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026014871 active site 1173026014872 phosphorylation site [posttranslational modification] 1173026014873 intermolecular recognition site; other site 1173026014874 dimerization interface [polypeptide binding]; other site 1173026014875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1173026014876 Histidine kinase; Region: HisKA_3; pfam07730 1173026014877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026014878 ATP binding site [chemical binding]; other site 1173026014879 Mg2+ binding site [ion binding]; other site 1173026014880 G-X-G motif; other site 1173026014881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026014882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026014883 active site 1173026014884 phosphorylation site [posttranslational modification] 1173026014885 intermolecular recognition site; other site 1173026014886 dimerization interface [polypeptide binding]; other site 1173026014887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026014888 DNA binding residues [nucleotide binding] 1173026014889 dimerization interface [polypeptide binding]; other site 1173026014890 Beta/Gamma crystallin; Region: Crystall; pfam00030 1173026014891 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1173026014892 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1173026014893 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1173026014894 Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476 1173026014895 putative active site [active] 1173026014896 putative catalytic triad [active] 1173026014897 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 1173026014898 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1173026014899 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1173026014900 active site 1173026014901 TDP-binding site; other site 1173026014902 acceptor substrate-binding pocket; other site 1173026014903 homodimer interface [polypeptide binding]; other site 1173026014904 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1173026014905 active site 1173026014906 catalytic triad [active] 1173026014907 oxyanion hole [active] 1173026014908 bile acid transporter; Region: bass; TIGR00841 1173026014909 Sodium Bile acid symporter family; Region: SBF; cl17470 1173026014910 SnoaL-like domain; Region: SnoaL_2; pfam12680 1173026014911 PBP superfamily domain; Region: PBP_like_2; cl17296 1173026014912 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1173026014913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026014914 dimer interface [polypeptide binding]; other site 1173026014915 conserved gate region; other site 1173026014916 putative PBP binding loops; other site 1173026014917 ABC-ATPase subunit interface; other site 1173026014918 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1173026014919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1173026014920 dimer interface [polypeptide binding]; other site 1173026014921 conserved gate region; other site 1173026014922 putative PBP binding loops; other site 1173026014923 ABC-ATPase subunit interface; other site 1173026014924 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1173026014925 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1173026014926 catalytic residues [active] 1173026014927 catalytic nucleophile [active] 1173026014928 Presynaptic Site I dimer interface [polypeptide binding]; other site 1173026014929 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1173026014930 Synaptic Flat tetramer interface [polypeptide binding]; other site 1173026014931 Synaptic Site I dimer interface [polypeptide binding]; other site 1173026014932 DNA binding site [nucleotide binding] 1173026014933 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1173026014934 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1173026014935 putative C-terminal domain interface [polypeptide binding]; other site 1173026014936 putative GSH binding site (G-site) [chemical binding]; other site 1173026014937 putative dimer interface [polypeptide binding]; other site 1173026014938 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1173026014939 putative N-terminal domain interface [polypeptide binding]; other site 1173026014940 putative dimer interface [polypeptide binding]; other site 1173026014941 putative substrate binding pocket (H-site) [chemical binding]; other site 1173026014942 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1173026014943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1173026014944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1173026014945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1173026014946 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1173026014947 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1173026014948 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1173026014949 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1173026014950 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1173026014951 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1173026014952 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1173026014953 ligand binding site [chemical binding]; other site 1173026014954 flexible hinge region; other site 1173026014955 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1173026014956 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 1173026014957 putative active site [active] 1173026014958 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1173026014959 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1173026014960 Walker A/P-loop; other site 1173026014961 ATP binding site [chemical binding]; other site 1173026014962 Q-loop/lid; other site 1173026014963 ABC transporter signature motif; other site 1173026014964 Walker B; other site 1173026014965 D-loop; other site 1173026014966 H-loop/switch region; other site 1173026014967 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1173026014968 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173026014969 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1173026014970 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026014971 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173026014972 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173026014973 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1173026014974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1173026014975 Beta-lactamase; Region: Beta-lactamase; pfam00144 1173026014976 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026014977 putative active site [active] 1173026014978 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173026014979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026014980 putative substrate translocation pore; other site 1173026014981 AMIN domain; Region: AMIN; pfam11741 1173026014982 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1173026014983 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1173026014984 N-terminal plug; other site 1173026014985 ligand-binding site [chemical binding]; other site 1173026014986 acyl-CoA synthetase; Validated; Region: PRK05850 1173026014987 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1173026014988 acyl-activating enzyme (AAE) consensus motif; other site 1173026014989 active site 1173026014990 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1173026014991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1173026014992 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1173026014993 active site 1173026014994 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173026014995 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1173026014996 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026014997 active site 1173026014998 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173026014999 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1173026015000 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173026015001 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026015002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026015003 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1173026015004 Enoylreductase; Region: PKS_ER; smart00829 1173026015005 NAD(P) binding site [chemical binding]; other site 1173026015006 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1173026015007 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173026015008 putative NADP binding site [chemical binding]; other site 1173026015009 active site 1173026015010 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173026015011 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1173026015012 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026015013 active site 1173026015014 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173026015015 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1173026015016 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1173026015017 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1173026015018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026015019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026015020 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1173026015021 Enoylreductase; Region: PKS_ER; smart00829 1173026015022 NAD(P) binding site [chemical binding]; other site 1173026015023 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1173026015024 KR domain; Region: KR; pfam08659 1173026015025 putative NADP binding site [chemical binding]; other site 1173026015026 active site 1173026015027 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1173026015028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1173026015029 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1173026015030 active site 1173026015031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1173026015032 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1173026015033 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1173026015034 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1173026015035 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1173026015036 putative NADP binding site [chemical binding]; other site 1173026015037 active site 1173026015038 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026015039 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1173026015040 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1173026015041 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1173026015042 Condensation domain; Region: Condensation; pfam00668 1173026015043 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026015044 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026015045 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026015046 acyl-activating enzyme (AAE) consensus motif; other site 1173026015047 AMP binding site [chemical binding]; other site 1173026015048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026015049 Condensation domain; Region: Condensation; pfam00668 1173026015050 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026015051 Condensation domain; Region: Condensation; pfam00668 1173026015052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026015053 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1173026015054 acyl-activating enzyme (AAE) consensus motif; other site 1173026015055 AMP binding site [chemical binding]; other site 1173026015056 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026015057 Condensation domain; Region: Condensation; pfam00668 1173026015058 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1173026015059 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1173026015060 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1173026015061 acyl-activating enzyme (AAE) consensus motif; other site 1173026015062 AMP binding site [chemical binding]; other site 1173026015063 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1173026015064 Condensation domain; Region: Condensation; pfam00668 1173026015065 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1173026015066 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1173026015067 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1173026015068 putative dimer interface [polypeptide binding]; other site 1173026015069 putative [2Fe-2S] cluster binding site [ion binding]; other site 1173026015070 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1173026015071 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026015072 active site 1173026015073 catalytic residues [active] 1173026015074 DNA binding site [nucleotide binding] 1173026015075 Int/Topo IB signature motif; other site 1173026015076 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173026015077 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026015078 P-loop; other site 1173026015079 Magnesium ion binding site [ion binding]; other site 1173026015080 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026015081 Magnesium ion binding site [ion binding]; other site 1173026015082 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1173026015083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1173026015084 ATP binding site [chemical binding]; other site 1173026015085 putative Mg++ binding site [ion binding]; other site 1173026015086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026015087 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1173026015088 nucleotide binding region [chemical binding]; other site 1173026015089 ATP-binding site [chemical binding]; other site 1173026015090 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1173026015091 Domain of unknown function DUF29; Region: DUF29; pfam01724 1173026015092 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1173026015093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1173026015094 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1173026015095 Walker A/P-loop; other site 1173026015096 ATP binding site [chemical binding]; other site 1173026015097 AAA domain; Region: AAA_21; pfam13304 1173026015098 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1173026015099 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 1173026015100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1173026015101 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1173026015102 four helix bundle protein; Region: TIGR02436 1173026015103 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1173026015104 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1173026015105 NACHT domain; Region: NACHT; pfam05729 1173026015106 HEAT repeats; Region: HEAT_2; pfam13646 1173026015107 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 1173026015108 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1173026015109 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 1173026015110 active site 1173026015111 metal binding site [ion binding]; metal-binding site 1173026015112 conjugal transfer protein TraL; Provisional; Region: PRK13886 1173026015113 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026015114 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026015115 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026015116 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1173026015117 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026015118 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1173026015119 LexA regulated protein; Provisional; Region: PRK11675 1173026015120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173026015121 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1173026015122 active site 1173026015123 DNA binding site [nucleotide binding] 1173026015124 Int/Topo IB signature motif; other site 1173026015125 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1173026015126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026015127 non-specific DNA binding site [nucleotide binding]; other site 1173026015128 salt bridge; other site 1173026015129 sequence-specific DNA binding site [nucleotide binding]; other site 1173026015130 PIN domain; Region: PIN_3; pfam13470 1173026015131 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1173026015132 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173026015133 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1173026015134 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026015135 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1173026015136 GSH binding site [chemical binding]; other site 1173026015137 catalytic residues [active] 1173026015138 flavodoxin FldA; Validated; Region: PRK09267 1173026015139 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1173026015140 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173026015141 DNA binding residues [nucleotide binding] 1173026015142 dimer interface [polypeptide binding]; other site 1173026015143 metal binding site [ion binding]; metal-binding site 1173026015144 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 1173026015145 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173026015146 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1173026015147 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173026015148 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173026015149 metal-binding site [ion binding] 1173026015150 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026015151 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026015152 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173026015153 metal-binding site [ion binding] 1173026015154 hypothetical protein; Provisional; Region: PRK07236 1173026015155 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1173026015156 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026015157 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1173026015158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1173026015159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026015160 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1173026015161 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1173026015162 catalytic residues [active] 1173026015163 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1173026015164 Thioredoxin; Region: Thioredoxin_4; cl17273 1173026015165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1173026015166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026015167 active site 1173026015168 phosphorylation site [posttranslational modification] 1173026015169 intermolecular recognition site; other site 1173026015170 dimerization interface [polypeptide binding]; other site 1173026015171 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1173026015172 DNA binding residues [nucleotide binding] 1173026015173 dimerization interface [polypeptide binding]; other site 1173026015174 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026015175 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026015176 PAS domain S-box; Region: sensory_box; TIGR00229 1173026015177 PAS domain S-box; Region: sensory_box; TIGR00229 1173026015178 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1173026015179 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1173026015180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1173026015181 Histidine kinase; Region: HisKA_3; pfam07730 1173026015182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026015183 ATP binding site [chemical binding]; other site 1173026015184 Mg2+ binding site [ion binding]; other site 1173026015185 G-X-G motif; other site 1173026015186 glutathione reductase; Validated; Region: PRK06116 1173026015187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1173026015188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1173026015189 Ion channel; Region: Ion_trans_2; pfam07885 1173026015190 Domain of unknown function (DUF305); Region: DUF305; cl17794 1173026015191 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173026015192 dimerization interface [polypeptide binding]; other site 1173026015193 o-succinylbenzoate-CoA ligase; Region: PLN02860 1173026015194 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1173026015195 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1173026015196 dimerization interface [polypeptide binding]; other site 1173026015197 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1173026015198 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1173026015199 putative active site [active] 1173026015200 catalytic triad [active] 1173026015201 putative dimer interface [polypeptide binding]; other site 1173026015202 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173026015203 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1173026015204 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173026015205 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1173026015206 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173026015207 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1173026015208 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1173026015209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1173026015210 HlyD family secretion protein; Region: HlyD_3; pfam13437 1173026015211 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173026015212 S-layer homology domain; Region: SLH; pfam00395 1173026015213 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026015214 S-layer homology domain; Region: SLH; pfam00395 1173026015215 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1173026015216 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173026015217 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 1173026015218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026015219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026015220 active site 1173026015221 phosphorylation site [posttranslational modification] 1173026015222 intermolecular recognition site; other site 1173026015223 dimerization interface [polypeptide binding]; other site 1173026015224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026015225 DNA binding site [nucleotide binding] 1173026015226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026015227 dimer interface [polypeptide binding]; other site 1173026015228 phosphorylation site [posttranslational modification] 1173026015229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026015230 ATP binding site [chemical binding]; other site 1173026015231 Mg2+ binding site [ion binding]; other site 1173026015232 G-X-G motif; other site 1173026015233 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 1173026015234 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1173026015235 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173026015236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026015237 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026015238 CAAX protease self-immunity; Region: Abi; pfam02517 1173026015239 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1173026015240 TPR repeat; Region: TPR_11; pfam13414 1173026015241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026015242 binding surface 1173026015243 TPR motif; other site 1173026015244 TPR repeat; Region: TPR_11; pfam13414 1173026015245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026015246 binding surface 1173026015247 TPR motif; other site 1173026015248 TPR repeat; Region: TPR_11; pfam13414 1173026015249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026015250 binding surface 1173026015251 TPR motif; other site 1173026015252 TPR repeat; Region: TPR_11; pfam13414 1173026015253 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 1173026015254 substrate binding site [chemical binding]; other site 1173026015255 putative active site [active] 1173026015256 redox center [active] 1173026015257 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026015258 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173026015259 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173026015260 metal-binding site [ion binding] 1173026015261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1173026015262 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1173026015263 metal-binding site [ion binding] 1173026015264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1173026015265 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1173026015266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1173026015267 dimerization interface [polypeptide binding]; other site 1173026015268 putative DNA binding site [nucleotide binding]; other site 1173026015269 putative Zn2+ binding site [ion binding]; other site 1173026015270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1173026015271 dimer interface [polypeptide binding]; other site 1173026015272 phosphorylation site [posttranslational modification] 1173026015273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1173026015274 ATP binding site [chemical binding]; other site 1173026015275 Mg2+ binding site [ion binding]; other site 1173026015276 G-X-G motif; other site 1173026015277 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1173026015278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1173026015279 active site 1173026015280 phosphorylation site [posttranslational modification] 1173026015281 intermolecular recognition site; other site 1173026015282 dimerization interface [polypeptide binding]; other site 1173026015283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1173026015284 DNA binding site [nucleotide binding] 1173026015285 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1173026015286 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1173026015287 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1173026015288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1173026015289 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1173026015290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1173026015291 DNA binding residues [nucleotide binding] 1173026015292 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1173026015293 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1173026015294 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1173026015295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1173026015296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1173026015297 TIGR04255 family protein; Region: sporadTIGR04255 1173026015298 H+ Antiporter protein; Region: 2A0121; TIGR00900 1173026015299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026015300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1173026015301 mechanosensitive channel MscS; Provisional; Region: PRK10334 1173026015302 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1173026015303 Domain of unknown function DUF21; Region: DUF21; pfam01595 1173026015304 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1173026015305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1173026015306 Transporter associated domain; Region: CorC_HlyC; smart01091 1173026015307 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1173026015308 hypothetical protein; Provisional; Region: PRK02237 1173026015309 Domain of unknown function (DUF305); Region: DUF305; cl17794 1173026015310 Domain of unknown function (DUF305); Region: DUF305; cl17794 1173026015311 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1173026015312 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1173026015313 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1173026015314 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1173026015315 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1173026015316 iron-sulfur cluster [ion binding]; other site 1173026015317 [2Fe-2S] cluster binding site [ion binding]; other site 1173026015318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026015319 TPR repeat; Region: TPR_11; pfam13414 1173026015320 binding surface 1173026015321 TPR motif; other site 1173026015322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1173026015323 binding surface 1173026015324 TPR motif; other site 1173026015325 TPR repeat; Region: TPR_11; pfam13414 1173026015326 TPR repeat; Region: TPR_11; pfam13414 1173026015327 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1173026015328 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1173026015329 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1173026015330 Asp-box motif; other site 1173026015331 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1173026015332 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173026015333 DNA binding residues [nucleotide binding] 1173026015334 dimer interface [polypeptide binding]; other site 1173026015335 metal binding site [ion binding]; metal-binding site 1173026015336 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 1173026015337 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1173026015338 DNA binding residues [nucleotide binding] 1173026015339 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1173026015340 dimer interface [polypeptide binding]; other site 1173026015341 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1173026015342 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1173026015343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026015344 non-specific DNA binding site [nucleotide binding]; other site 1173026015345 salt bridge; other site 1173026015346 sequence-specific DNA binding site [nucleotide binding]; other site 1173026015347 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1173026015348 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173026015349 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1173026015350 P loop; other site 1173026015351 Nucleotide binding site [chemical binding]; other site 1173026015352 DTAP/Switch II; other site 1173026015353 Switch I; other site 1173026015354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026015355 Magnesium ion binding site [ion binding]; other site 1173026015356 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1173026015357 ParB-like nuclease domain; Region: ParBc; pfam02195 1173026015358 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1173026015359 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1173026015360 active site 1173026015361 interdomain interaction site; other site 1173026015362 putative metal-binding site [ion binding]; other site 1173026015363 nucleotide binding site [chemical binding]; other site 1173026015364 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1173026015365 domain I; other site 1173026015366 phosphate binding site [ion binding]; other site 1173026015367 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1173026015368 domain II; other site 1173026015369 domain III; other site 1173026015370 nucleotide binding site [chemical binding]; other site 1173026015371 DNA binding groove [nucleotide binding] 1173026015372 catalytic site [active] 1173026015373 domain IV; other site 1173026015374 AAA-like domain; Region: AAA_10; pfam12846 1173026015375 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1173026015376 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 1173026015377 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 1173026015378 AAA domain; Region: AAA_30; pfam13604 1173026015379 Family description; Region: UvrD_C_2; pfam13538 1173026015380 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1173026015381 DNA polymerase III subunit beta; Validated; Region: PRK05643 1173026015382 putative DNA binding surface [nucleotide binding]; other site 1173026015383 dimer interface [polypeptide binding]; other site 1173026015384 beta-clamp/clamp loader binding surface; other site 1173026015385 beta-clamp/translesion DNA polymerase binding surface; other site 1173026015386 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1173026015387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1173026015388 Walker A motif; other site 1173026015389 ATP binding site [chemical binding]; other site 1173026015390 Walker B motif; other site 1173026015391 arginine finger; other site 1173026015392 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1173026015393 DNA polymerase III subunit delta; Validated; Region: PRK07452 1173026015394 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1173026015395 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1173026015396 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1173026015397 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1173026015398 nucleotide binding region [chemical binding]; other site 1173026015399 ATP-binding site [chemical binding]; other site 1173026015400 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1173026015401 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1173026015402 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026015403 active site 1173026015404 NTP binding site [chemical binding]; other site 1173026015405 metal binding triad [ion binding]; metal-binding site 1173026015406 antibiotic binding site [chemical binding]; other site 1173026015407 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1173026015408 active site 1173026015409 NTP binding site [chemical binding]; other site 1173026015410 metal binding triad [ion binding]; metal-binding site 1173026015411 antibiotic binding site [chemical binding]; other site 1173026015412 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1173026015413 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1173026015414 AAA-like domain; Region: AAA_10; pfam12846 1173026015415 Walker A motif; other site 1173026015416 ATP binding site [chemical binding]; other site 1173026015417 Walker B motif; other site 1173026015418 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1173026015419 Peptidase family M23; Region: Peptidase_M23; pfam01551 1173026015420 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1173026015421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1173026015422 S-adenosylmethionine binding site [chemical binding]; other site 1173026015423 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1173026015424 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1173026015425 active site 1173026015426 catalytic site [active] 1173026015427 substrate binding site [chemical binding]; other site 1173026015428 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1173026015429 active site 1173026015430 DNA binding site [nucleotide binding] 1173026015431 catalytic site [active] 1173026015432 Ycf46; Provisional; Region: ycf46; CHL00195 1173026015433 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1173026015434 Walker A motif; other site 1173026015435 ATP binding site [chemical binding]; other site 1173026015436 Walker B motif; other site 1173026015437 arginine finger; other site 1173026015438 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1173026015439 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1173026015440 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1173026015441 Mg binding site [ion binding]; other site 1173026015442 nucleotide binding site [chemical binding]; other site 1173026015443 putative protofilament interface [polypeptide binding]; other site 1173026015444 conjugal transfer protein TraL; Provisional; Region: PRK13886 1173026015445 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1173026015446 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1173026015447 ATP binding site [chemical binding]; other site 1173026015448 substrate interface [chemical binding]; other site 1173026015449 PRTRC system protein A; Region: PRTRC_A; TIGR03735 1173026015450 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1173026015451 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 1173026015452 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1173026015453 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1173026015454 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1173026015455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1173026015456 salt bridge; other site 1173026015457 non-specific DNA binding site [nucleotide binding]; other site 1173026015458 sequence-specific DNA binding site [nucleotide binding]; other site 1173026015459 ParB-like nuclease domain; Region: ParB; smart00470 1173026015460 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1173026015461 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 1173026015462 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1173026015463 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1173026015464 Herpesvirus putative major envelope glycoprotein; Region: Herpes_env; pfam01673 1173026015465 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026015466 active site 1173026015467 catalytic residues [active] 1173026015468 DNA binding site [nucleotide binding] 1173026015469 Int/Topo IB signature motif; other site 1173026015470 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1173026015471 DNA binding site [nucleotide binding] 1173026015472 Int/Topo IB signature motif; other site 1173026015473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 1173026015474 Integrase core domain; Region: rve; pfam00665 1173026015475 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1173026015476 putative active site [active] 1173026015477 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 1173026015478 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 1173026015479 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1173026015480 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1173026015481 ATP binding site [chemical binding]; other site 1173026015482 substrate interface [chemical binding]; other site 1173026015483 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1173026015484 metal binding triad [ion binding]; metal-binding site 1173026015485 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 1173026015486 active site 1173026015487 nucleophile elbow; other site 1173026015488 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1173026015489 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1173026015490 P-loop; other site 1173026015491 Magnesium ion binding site [ion binding]; other site 1173026015492 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1173026015493 active site 1173026015494 catalytic residues [active] 1173026015495 DNA binding site [nucleotide binding] 1173026015496 Int/Topo IB signature motif; other site