-- dump date 20140619_102510 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243231000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 243231000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 243231000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231000004 Walker A motif; other site 243231000005 ATP binding site [chemical binding]; other site 243231000006 Walker B motif; other site 243231000007 arginine finger; other site 243231000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243231000009 DnaA box-binding interface [nucleotide binding]; other site 243231000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 243231000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243231000012 putative DNA binding surface [nucleotide binding]; other site 243231000013 dimer interface [polypeptide binding]; other site 243231000014 beta-clamp/clamp loader binding surface; other site 243231000015 beta-clamp/translesion DNA polymerase binding surface; other site 243231000016 recombination protein F; Reviewed; Region: recF; PRK00064 243231000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231000018 Walker A/P-loop; other site 243231000019 ATP binding site [chemical binding]; other site 243231000020 Q-loop/lid; other site 243231000021 ABC transporter signature motif; other site 243231000022 Walker B; other site 243231000023 D-loop; other site 243231000024 H-loop/switch region; other site 243231000025 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 243231000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000027 ATP binding site [chemical binding]; other site 243231000028 Mg2+ binding site [ion binding]; other site 243231000029 G-X-G motif; other site 243231000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243231000031 anchoring element; other site 243231000032 dimer interface [polypeptide binding]; other site 243231000033 ATP binding site [chemical binding]; other site 243231000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243231000035 active site 243231000036 putative metal-binding site [ion binding]; other site 243231000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243231000038 palindrome; GSUR0083 243231000039 DNA gyrase subunit A; Validated; Region: PRK05560 243231000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243231000041 CAP-like domain; other site 243231000042 active site 243231000043 primary dimer interface [polypeptide binding]; other site 243231000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243231000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243231000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243231000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243231000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243231000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243231000050 HEAT repeats; Region: HEAT_2; pfam13646 243231000051 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 243231000052 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 243231000053 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 243231000054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 243231000055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231000056 dimerization interface [polypeptide binding]; other site 243231000057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000058 putative active site [active] 243231000059 heme pocket [chemical binding]; other site 243231000060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000061 dimer interface [polypeptide binding]; other site 243231000062 phosphorylation site [posttranslational modification] 243231000063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000064 ATP binding site [chemical binding]; other site 243231000065 Mg2+ binding site [ion binding]; other site 243231000066 G-X-G motif; other site 243231000067 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231000068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231000069 active site 243231000070 phosphorylation site [posttranslational modification] 243231000071 intermolecular recognition site; other site 243231000072 dimerization interface [polypeptide binding]; other site 243231000073 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231000074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000075 putative active site [active] 243231000076 heme pocket [chemical binding]; other site 243231000077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000078 dimer interface [polypeptide binding]; other site 243231000079 phosphorylation site [posttranslational modification] 243231000080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000081 ATP binding site [chemical binding]; other site 243231000082 Mg2+ binding site [ion binding]; other site 243231000083 G-X-G motif; other site 243231000084 PAS domain S-box; Region: sensory_box; TIGR00229 243231000085 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000087 dimer interface [polypeptide binding]; other site 243231000088 phosphorylation site [posttranslational modification] 243231000089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000090 ATP binding site [chemical binding]; other site 243231000091 Mg2+ binding site [ion binding]; other site 243231000092 G-X-G motif; other site 243231000093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231000094 active site 243231000095 phosphorylation site [posttranslational modification] 243231000096 intermolecular recognition site; other site 243231000097 dimerization interface [polypeptide binding]; other site 243231000098 PAS domain; Region: PAS_9; pfam13426 243231000099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000100 putative active site [active] 243231000101 heme pocket [chemical binding]; other site 243231000102 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243231000103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231000104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000105 dimer interface [polypeptide binding]; other site 243231000106 phosphorylation site [posttranslational modification] 243231000107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000108 ATP binding site [chemical binding]; other site 243231000109 Mg2+ binding site [ion binding]; other site 243231000110 G-X-G motif; other site 243231000111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231000112 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 243231000113 Walker A/P-loop; other site 243231000114 ATP binding site [chemical binding]; other site 243231000115 Q-loop/lid; other site 243231000116 ABC transporter signature motif; other site 243231000117 Walker B; other site 243231000118 D-loop; other site 243231000119 H-loop/switch region; other site 243231000120 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 243231000121 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 243231000122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243231000123 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243231000124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243231000125 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 243231000126 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243231000127 HSP70 interaction site [polypeptide binding]; other site 243231000128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243231000129 substrate binding site [polypeptide binding]; other site 243231000130 dimer interface [polypeptide binding]; other site 243231000131 SurA N-terminal domain; Region: SurA_N; pfam09312 243231000132 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243231000133 SurA N-terminal domain; Region: SurA_N_3; cl07813 243231000134 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 243231000135 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243231000136 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 243231000137 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 243231000138 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 243231000139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231000140 ATP binding site [chemical binding]; other site 243231000141 putative Mg++ binding site [ion binding]; other site 243231000142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231000143 nucleotide binding region [chemical binding]; other site 243231000144 ATP-binding site [chemical binding]; other site 243231000145 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 243231000146 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 243231000147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243231000148 DNA-binding site [nucleotide binding]; DNA binding site 243231000149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231000150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231000151 homodimer interface [polypeptide binding]; other site 243231000152 catalytic residue [active] 243231000153 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243231000154 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243231000155 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243231000156 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 243231000157 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 243231000158 trimer interface [polypeptide binding]; other site 243231000159 putative metal binding site [ion binding]; other site 243231000160 Quinolinate synthetase A protein; Region: NadA; pfam02445 243231000161 twin arginine translocase protein A; Provisional; Region: tatA; PRK14858 243231000162 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243231000163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231000164 binding surface 243231000165 TPR motif; other site 243231000166 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231000167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231000168 ligand binding site [chemical binding]; other site 243231000169 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 243231000170 TolB amino-terminal domain; Region: TolB_N; pfam04052 243231000171 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243231000172 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243231000173 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243231000174 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243231000175 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 243231000176 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243231000177 TonB C terminal; Region: TonB_2; pfam13103 243231000178 TolR protein; Region: tolR; TIGR02801 243231000179 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243231000180 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 243231000181 putative active site [active] 243231000182 catalytic triad [active] 243231000183 putative dimer interface [polypeptide binding]; other site 243231000184 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 243231000185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000186 FeS/SAM binding site; other site 243231000187 HemN C-terminal domain; Region: HemN_C; pfam06969 243231000188 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 243231000189 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 243231000190 HrcA protein C terminal domain; Region: HrcA; pfam01628 243231000191 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243231000192 dimer interface [polypeptide binding]; other site 243231000193 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243231000194 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243231000195 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 243231000196 nucleotide binding site [chemical binding]; other site 243231000197 chaperone protein DnaJ; Provisional; Region: PRK10767 243231000198 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243231000199 HSP70 interaction site [polypeptide binding]; other site 243231000200 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243231000201 substrate binding site [polypeptide binding]; other site 243231000202 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243231000203 Zn binding sites [ion binding]; other site 243231000204 dimer interface [polypeptide binding]; other site 243231000205 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 243231000206 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 243231000207 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 243231000208 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 243231000209 putative active site [active] 243231000210 putative metal binding site [ion binding]; other site 243231000211 seryl-tRNA synthetase; Provisional; Region: PRK05431 243231000212 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243231000213 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243231000214 dimer interface [polypeptide binding]; other site 243231000215 active site 243231000216 motif 1; other site 243231000217 motif 2; other site 243231000218 motif 3; other site 243231000219 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970 243231000220 Uncharacterized conserved protein [Function unknown]; Region: COG2135 243231000221 LexA repressor; Validated; Region: PRK00215 243231000222 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243231000223 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243231000224 Catalytic site [active] 243231000225 DNA polymerase IV; Reviewed; Region: PRK03103 243231000226 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243231000227 active site 243231000228 DNA binding site [nucleotide binding] 243231000229 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 243231000230 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 243231000231 RHS Repeat; Region: RHS_repeat; pfam05593 243231000232 RHS Repeat; Region: RHS_repeat; pfam05593 243231000233 RHS Repeat; Region: RHS_repeat; pfam05593 243231000234 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 243231000235 Fn3 associated; Region: Fn3_assoc; pfam13287 243231000236 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 243231000237 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 243231000238 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 243231000239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 243231000240 Integrase core domain; Region: rve; pfam00665 243231000241 transposase/IS protein; Provisional; Region: PRK09183 243231000242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231000243 Walker A motif; other site 243231000244 ATP binding site [chemical binding]; other site 243231000245 Walker B motif; other site 243231000246 putative transposase OrfB; Reviewed; Region: PHA02517 243231000247 HTH-like domain; Region: HTH_21; pfam13276 243231000248 Integrase core domain; Region: rve; pfam00665 243231000249 Integrase core domain; Region: rve_3; pfam13683 243231000250 Predicted transcriptional regulator [Transcription]; Region: COG2378 243231000251 WYL domain; Region: WYL; pfam13280 243231000252 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 243231000253 CRISPR/Cas system-associated protein Cas3; Distinct Cas3 family with HD domain fused to C-termus of Helicase domain; Region: Cas3_I; cd09696 243231000254 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 243231000255 CRISPR/Cas system-associated protein Csx14; Region: Csx14_I-U; cd09765 243231000256 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cd09678 243231000257 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cd09734 243231000258 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 243231000259 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 243231000260 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 243231000261 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 243231000262 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 243231000263 conserved nucleotide sequence; similar to other Geobacter species; GSUR0084 243231000264 conserved nucleotide sequence; similar to other Geobacter species; GSUR0085 243231000265 Protein of unknown function (DUF3232); Region: DUF3232; pfam11554 243231000266 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243231000267 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 243231000268 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 243231000269 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 243231000270 active site 243231000271 Int/Topo IB signature motif; other site 243231000272 tRNA-Arg, fragment; GSUR0057 243231000273 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 243231000274 nucleoside/Zn binding site; other site 243231000275 dimer interface [polypeptide binding]; other site 243231000276 catalytic motif [active] 243231000277 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 243231000278 putative catalytic residues [active] 243231000279 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 243231000280 active site clefts [active] 243231000281 zinc binding site [ion binding]; other site 243231000282 dimer interface [polypeptide binding]; other site 243231000283 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231000284 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 243231000285 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243231000286 Polysulphide reductase, NrfD; Region: NrfD; cl19193 243231000287 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 243231000288 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 243231000289 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 243231000290 conserved cys residue [active] 243231000291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231000292 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243231000293 NAD(P) binding site [chemical binding]; other site 243231000294 active site 243231000295 PilZ domain; Region: PilZ; pfam07238 243231000296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231000297 non-specific DNA binding site [nucleotide binding]; other site 243231000298 salt bridge; other site 243231000299 sequence-specific DNA binding site [nucleotide binding]; other site 243231000300 Cupin domain; Region: Cupin_2; pfam07883 243231000301 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243231000302 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243231000303 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243231000304 protein binding site [polypeptide binding]; other site 243231000305 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243231000306 protein binding site [polypeptide binding]; other site 243231000307 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 243231000308 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231000309 RNA binding surface [nucleotide binding]; other site 243231000310 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243231000311 active site 243231000312 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 243231000313 hypothetical protein; Provisional; Region: PRK07550 243231000314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231000315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231000316 homodimer interface [polypeptide binding]; other site 243231000317 catalytic residue [active] 243231000318 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 243231000319 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 243231000320 FAD binding pocket [chemical binding]; other site 243231000321 FAD binding motif [chemical binding]; other site 243231000322 phosphate binding motif [ion binding]; other site 243231000323 beta-alpha-beta structure motif; other site 243231000324 NAD binding pocket [chemical binding]; other site 243231000325 Iron coordination center [ion binding]; other site 243231000326 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231000327 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 243231000328 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 243231000329 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 243231000330 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 243231000331 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 243231000332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243231000333 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 243231000334 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231000335 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 243231000336 Cysteine-rich domain; Region: CCG; pfam02754 243231000337 Cysteine-rich domain; Region: CCG; pfam02754 243231000338 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 243231000339 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231000340 conserved nucleotide sequence; similar to other Geobacter species; GSUR0086 243231000341 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243231000342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243231000343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231000344 Walker A/P-loop; other site 243231000345 ATP binding site [chemical binding]; other site 243231000346 Q-loop/lid; other site 243231000347 ABC transporter signature motif; other site 243231000348 Walker B; other site 243231000349 D-loop; other site 243231000350 H-loop/switch region; other site 243231000351 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 243231000352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231000353 Walker A motif; other site 243231000354 ATP binding site [chemical binding]; other site 243231000355 Walker B motif; other site 243231000356 arginine finger; other site 243231000357 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243231000358 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 243231000359 hypothetical protein; Validated; Region: PRK00153 243231000360 recombination protein RecR; Reviewed; Region: recR; PRK00076 243231000361 RecR protein; Region: RecR; pfam02132 243231000362 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 243231000363 putative active site [active] 243231000364 putative metal-binding site [ion binding]; other site 243231000365 tetramer interface [polypeptide binding]; other site 243231000366 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 243231000367 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243231000368 dimer interface [polypeptide binding]; other site 243231000369 PYR/PP interface [polypeptide binding]; other site 243231000370 TPP binding site [chemical binding]; other site 243231000371 substrate binding site [chemical binding]; other site 243231000372 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 243231000373 Domain of unknown function; Region: EKR; pfam10371 243231000374 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231000375 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 243231000376 TPP-binding site [chemical binding]; other site 243231000377 dimer interface [polypeptide binding]; other site 243231000378 conserved nucleotide sequence; similar to other Geobacter species; GSUR0087 243231000379 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 243231000380 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 243231000381 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 243231000382 G1 box; other site 243231000383 GTP/Mg2+ binding site [chemical binding]; other site 243231000384 G2 box; other site 243231000385 Switch I region; other site 243231000386 G3 box; other site 243231000387 Switch II region; other site 243231000388 G4 box; other site 243231000389 G5 box; other site 243231000390 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243231000391 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243231000392 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 243231000393 Walker A/P-loop; other site 243231000394 ATP binding site [chemical binding]; other site 243231000395 Q-loop/lid; other site 243231000396 ABC transporter signature motif; other site 243231000397 Walker B; other site 243231000398 D-loop; other site 243231000399 H-loop/switch region; other site 243231000400 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 243231000401 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 243231000402 G1 box; other site 243231000403 putative GEF interaction site [polypeptide binding]; other site 243231000404 GTP/Mg2+ binding site [chemical binding]; other site 243231000405 Switch I region; other site 243231000406 G2 box; other site 243231000407 G3 box; other site 243231000408 Switch II region; other site 243231000409 G4 box; other site 243231000410 G5 box; other site 243231000411 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 243231000412 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 243231000413 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 243231000414 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 243231000415 PAS domain; Region: PAS_8; pfam13188 243231000416 PAS fold; Region: PAS_4; pfam08448 243231000417 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231000418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000419 dimer interface [polypeptide binding]; other site 243231000420 phosphorylation site [posttranslational modification] 243231000421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000422 ATP binding site [chemical binding]; other site 243231000423 Mg2+ binding site [ion binding]; other site 243231000424 G-X-G motif; other site 243231000425 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231000426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231000427 active site 243231000428 phosphorylation site [posttranslational modification] 243231000429 intermolecular recognition site; other site 243231000430 dimerization interface [polypeptide binding]; other site 243231000431 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243231000432 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243231000433 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 243231000434 P-loop; other site 243231000435 Magnesium ion binding site [ion binding]; other site 243231000436 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 243231000437 ParB-like nuclease domain; Region: ParB; smart00470 243231000438 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 243231000439 conserved nucleotide sequence; similar to other Geobacter species; GSUR0088 243231000440 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 243231000441 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243231000442 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243231000443 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 243231000444 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 243231000445 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 243231000446 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243231000447 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243231000448 beta subunit interaction interface [polypeptide binding]; other site 243231000449 Walker A motif; other site 243231000450 ATP binding site [chemical binding]; other site 243231000451 Walker B motif; other site 243231000452 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243231000453 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243231000454 core domain interface [polypeptide binding]; other site 243231000455 delta subunit interface [polypeptide binding]; other site 243231000456 epsilon subunit interface [polypeptide binding]; other site 243231000457 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243231000458 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243231000459 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243231000460 alpha subunit interaction interface [polypeptide binding]; other site 243231000461 Walker A motif; other site 243231000462 ATP binding site [chemical binding]; other site 243231000463 Walker B motif; other site 243231000464 inhibitor binding site; inhibition site 243231000465 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243231000466 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 243231000467 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243231000468 gamma subunit interface [polypeptide binding]; other site 243231000469 epsilon subunit interface [polypeptide binding]; other site 243231000470 LBP interface [polypeptide binding]; other site 243231000471 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 243231000472 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 243231000473 Transglycosylase; Region: Transgly; pfam00912 243231000474 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 243231000475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231000476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231000477 homodimer interface [polypeptide binding]; other site 243231000478 catalytic residue [active] 243231000479 conserved nucleotide sequence; similar to other Geobacter species; GSUR0089 243231000480 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 243231000481 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 243231000482 active site 243231000483 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 243231000484 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 243231000485 putative substrate-binding site; other site 243231000486 nickel binding site [ion binding]; other site 243231000487 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243231000488 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 243231000489 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 243231000490 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 243231000491 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243231000492 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 243231000493 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 243231000494 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231000495 active site 243231000496 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243231000497 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243231000498 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243231000499 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231000500 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 243231000501 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 243231000502 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 243231000503 Ligand Binding Site [chemical binding]; other site 243231000504 TIGR00269 family protein; Region: TIGR00269 243231000505 primosome assembly protein PriA; Validated; Region: PRK05580 243231000506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231000507 ATP binding site [chemical binding]; other site 243231000508 putative Mg++ binding site [ion binding]; other site 243231000509 helicase superfamily c-terminal domain; Region: HELICc; smart00490 243231000510 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243231000511 active site 243231000512 catalytic residues [active] 243231000513 metal binding site [ion binding]; metal-binding site 243231000514 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 243231000515 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243231000516 putative active site [active] 243231000517 substrate binding site [chemical binding]; other site 243231000518 putative cosubstrate binding site; other site 243231000519 catalytic site [active] 243231000520 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243231000521 substrate binding site [chemical binding]; other site 243231000522 Protein of unknown function DUF116; Region: DUF116; pfam01976 243231000523 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 243231000524 Putative exonuclease, RdgC; Region: RdgC; cl01122 243231000525 ribonuclease Z; Provisional; Region: PRK02126 243231000526 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 243231000527 dimer interface [polypeptide binding]; other site 243231000528 active site 243231000529 Schiff base residues; other site 243231000530 Predicted membrane protein [Function unknown]; Region: COG2259 243231000531 PilZ domain; Region: PilZ; pfam07238 243231000532 conserved nucleotide sequence; similar to other Geobacter species; GSUR0090 243231000533 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 243231000534 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 243231000535 G1 box; other site 243231000536 putative GEF interaction site [polypeptide binding]; other site 243231000537 GTP/Mg2+ binding site [chemical binding]; other site 243231000538 Switch I region; other site 243231000539 G2 box; other site 243231000540 G3 box; other site 243231000541 Switch II region; other site 243231000542 G4 box; other site 243231000543 G5 box; other site 243231000544 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 243231000545 palindrome; GSUR0091 243231000546 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 243231000547 AIR carboxylase; Region: AIRC; smart01001 243231000548 hypothetical protein; Provisional; Region: PRK04194 243231000549 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 243231000550 tetramer interfaces [polypeptide binding]; other site 243231000551 binuclear metal-binding site [ion binding]; other site 243231000552 competence damage-inducible protein A; Provisional; Region: PRK00549 243231000553 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 243231000554 putative MPT binding site; other site 243231000555 Competence-damaged protein; Region: CinA; pfam02464 243231000556 PAS domain S-box; Region: sensory_box; TIGR00229 243231000557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000558 putative active site [active] 243231000559 heme pocket [chemical binding]; other site 243231000560 GAF domain; Region: GAF_2; pfam13185 243231000561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231000562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000563 dimer interface [polypeptide binding]; other site 243231000564 phosphorylation site [posttranslational modification] 243231000565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000566 ATP binding site [chemical binding]; other site 243231000567 Mg2+ binding site [ion binding]; other site 243231000568 G-X-G motif; other site 243231000569 conserved nucleotide sequence; similar to other Geobacter species; GSUR0092 243231000570 recombinase A; Provisional; Region: recA; PRK09354 243231000571 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 243231000572 hexamer interface [polypeptide binding]; other site 243231000573 Walker A motif; other site 243231000574 ATP binding site [chemical binding]; other site 243231000575 Walker B motif; other site 243231000576 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243231000577 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 243231000578 Walker A motif; other site 243231000579 ATP binding site [chemical binding]; other site 243231000580 Walker B motif; other site 243231000581 recombination regulator RecX; Reviewed; Region: recX; PRK00117 243231000582 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 243231000583 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243231000584 motif 1; other site 243231000585 active site 243231000586 motif 2; other site 243231000587 motif 3; other site 243231000588 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243231000589 Spectrin repeats; Region: SPEC; smart00150 243231000590 DHHA1 domain; Region: DHHA1; pfam02272 243231000591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231000592 active site 243231000593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231000594 phosphorylation site [posttranslational modification] 243231000595 intermolecular recognition site; other site 243231000596 dimerization interface [polypeptide binding]; other site 243231000597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000598 dimer interface [polypeptide binding]; other site 243231000599 phosphorylation site [posttranslational modification] 243231000600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000601 ATP binding site [chemical binding]; other site 243231000602 Mg2+ binding site [ion binding]; other site 243231000603 G-X-G motif; other site 243231000604 conserved nucleotide sequence; similar to other Geobacter species; GSUR0093 243231000605 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 243231000606 feedback inhibition sensing region; other site 243231000607 homohexameric interface [polypeptide binding]; other site 243231000608 nucleotide binding site [chemical binding]; other site 243231000609 N-acetyl-L-glutamate binding site [chemical binding]; other site 243231000610 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 243231000611 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243231000612 inhibitor-cofactor binding pocket; inhibition site 243231000613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231000614 catalytic residue [active] 243231000615 ornithine carbamoyltransferase; Provisional; Region: PRK00779 243231000616 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243231000617 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243231000618 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 243231000619 ANP binding site [chemical binding]; other site 243231000620 Substrate Binding Site II [chemical binding]; other site 243231000621 Substrate Binding Site I [chemical binding]; other site 243231000622 conserved nucleotide sequence; similar to other Geobacter species; GSUR0094 243231000623 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 243231000624 nudix motif; other site 243231000625 argininosuccinate lyase; Provisional; Region: PRK00855 243231000626 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 243231000627 active sites [active] 243231000628 tetramer interface [polypeptide binding]; other site 243231000629 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231000630 Interdomain contacts; other site 243231000631 Cytokine receptor motif; other site 243231000632 conserved nucleotide sequence; similar to other Geobacter species; GSUR0095 243231000633 diaminopimelate decarboxylase; Region: lysA; TIGR01048 243231000634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 243231000635 active site 243231000636 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243231000637 substrate binding site [chemical binding]; other site 243231000638 catalytic residues [active] 243231000639 dimer interface [polypeptide binding]; other site 243231000640 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 243231000641 dimer interface [polypeptide binding]; other site 243231000642 active site 243231000643 catalytic residue [active] 243231000644 dihydrodipicolinate reductase; Provisional; Region: PRK00048 243231000645 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 243231000646 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 243231000647 conserved nucleotide sequence; similar to other Geobacter species; GSUR1001 243231000648 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 243231000649 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231000650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231000651 homodimer interface [polypeptide binding]; other site 243231000652 catalytic residue [active] 243231000653 Predicted transcriptional regulator [Transcription]; Region: COG4190 243231000654 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 243231000655 AAA domain; Region: AAA_21; pfam13304 243231000656 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 243231000657 Transposase IS200 like; Region: Y1_Tnp; cl00848 243231000658 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 243231000659 Fic family protein [Function unknown]; Region: COG3177 243231000660 Fic/DOC family; Region: Fic; pfam02661 243231000661 MarR family; Region: MarR_2; pfam12802 243231000662 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 243231000663 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231000664 ABC transporter; Region: ABC_tran_2; pfam12848 243231000665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231000666 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243231000667 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 243231000668 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 243231000669 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 243231000670 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 243231000671 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 243231000672 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 243231000673 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243231000674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231000675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231000676 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 243231000677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243231000678 Coenzyme A binding pocket [chemical binding]; other site 243231000679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 243231000680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243231000681 dimerization interface [polypeptide binding]; other site 243231000682 putative DNA binding site [nucleotide binding]; other site 243231000683 putative Zn2+ binding site [ion binding]; other site 243231000684 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 243231000685 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 243231000686 TPR repeat; Region: TPR_11; pfam13414 243231000687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231000688 binding surface 243231000689 TPR motif; other site 243231000690 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243231000691 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231000692 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243231000693 Sporulation related domain; Region: SPOR; pfam05036 243231000694 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 243231000695 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243231000696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231000697 motif II; other site 243231000698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231000699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243231000700 putative substrate translocation pore; other site 243231000701 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 243231000702 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 243231000703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231000704 palindrome; GSUR0096 243231000705 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 243231000706 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243231000707 ATP binding site [chemical binding]; other site 243231000708 Mg++ binding site [ion binding]; other site 243231000709 motif III; other site 243231000710 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231000711 nucleotide binding region [chemical binding]; other site 243231000712 ATP-binding site [chemical binding]; other site 243231000713 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 243231000714 putative RNA binding site [nucleotide binding]; other site 243231000715 conserved palindrome; GSUR0097 243231000716 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243231000717 DNA-binding site [nucleotide binding]; DNA binding site 243231000718 RNA-binding motif; other site 243231000719 conserved nucleotide sequence; similar to other Geobacter species; GSUR0098 243231000720 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 243231000721 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 243231000722 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 243231000723 Dodecin; Region: Dodecin; pfam07311 243231000724 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243231000725 CoenzymeA binding site [chemical binding]; other site 243231000726 subunit interaction site [polypeptide binding]; other site 243231000727 PHB binding site; other site 243231000728 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 243231000729 malonic semialdehyde reductase; Provisional; Region: PRK10538 243231000730 putative NAD(P) binding site [chemical binding]; other site 243231000731 homodimer interface [polypeptide binding]; other site 243231000732 homotetramer interface [polypeptide binding]; other site 243231000733 active site 243231000734 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 243231000735 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 243231000736 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 243231000737 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243231000738 catalytic loop [active] 243231000739 iron binding site [ion binding]; other site 243231000740 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 243231000741 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 243231000742 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243231000743 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 243231000744 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 243231000745 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 243231000746 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 243231000747 XdhC Rossmann domain; Region: XdhC_C; pfam13478 243231000748 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 243231000749 Ligand binding site; other site 243231000750 metal-binding site 243231000751 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 243231000752 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231000753 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243231000754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231000755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231000756 Bacterial transcriptional repressor; Region: TetR; pfam13972 243231000757 zinc transporter ZupT; Provisional; Region: PRK04201 243231000758 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243231000759 DNA-binding site [nucleotide binding]; DNA binding site 243231000760 RNA-binding motif; other site 243231000761 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243231000762 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 243231000763 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 243231000764 zinc binding site [ion binding]; other site 243231000765 putative ligand binding site [chemical binding]; other site 243231000766 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 243231000767 TM-ABC transporter signature motif; other site 243231000768 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 243231000769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231000770 Walker A/P-loop; other site 243231000771 ATP binding site [chemical binding]; other site 243231000772 Q-loop/lid; other site 243231000773 ABC transporter signature motif; other site 243231000774 Walker B; other site 243231000775 D-loop; other site 243231000776 H-loop/switch region; other site 243231000777 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243231000778 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231000779 conserved nucleotide sequence; similar to other Geobacter species; GSUR0099 243231000780 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243231000781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231000782 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243231000783 Walker A motif; other site 243231000784 ATP binding site [chemical binding]; other site 243231000785 Walker B motif; other site 243231000786 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243231000787 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 243231000788 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243231000789 homodimer interface [polypeptide binding]; other site 243231000790 NADP binding site [chemical binding]; other site 243231000791 substrate binding site [chemical binding]; other site 243231000792 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 243231000793 putative FMN binding site [chemical binding]; other site 243231000794 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243231000795 Cu(I) binding site [ion binding]; other site 243231000796 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 243231000797 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 243231000798 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 243231000799 Subunit I/III interface [polypeptide binding]; other site 243231000800 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 243231000801 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 243231000802 Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_2; cd13915 243231000803 CuA binuclear center [ion binding]; other site 243231000804 Cytochrome c; Region: Cytochrom_C; pfam00034 243231000805 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 243231000806 putative active site [active] 243231000807 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 243231000808 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 243231000809 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 243231000810 cofactor binding site; other site 243231000811 DNA binding site [nucleotide binding] 243231000812 substrate interaction site [chemical binding]; other site 243231000813 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243231000814 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 243231000815 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 243231000816 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 243231000817 dimer interface [polypeptide binding]; other site 243231000818 acyl-activating enzyme (AAE) consensus motif; other site 243231000819 putative active site [active] 243231000820 AMP binding site [chemical binding]; other site 243231000821 putative CoA binding site [chemical binding]; other site 243231000822 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243231000823 Walker A motif; other site 243231000824 ATP binding site [chemical binding]; other site 243231000825 Walker B motif; other site 243231000826 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 243231000827 Protein of unknown function, DUF480; Region: DUF480; pfam04337 243231000828 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 243231000829 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 243231000830 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 243231000831 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 243231000832 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 243231000833 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243231000834 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 243231000835 RNA binding site [nucleotide binding]; other site 243231000836 Protein of unknown function, DUF393; Region: DUF393; pfam04134 243231000837 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 243231000838 putative active site [active] 243231000839 putative catalytic site [active] 243231000840 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243231000841 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 243231000842 B12 binding site [chemical binding]; other site 243231000843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000844 FeS/SAM binding site; other site 243231000845 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243231000846 active site 243231000847 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243231000848 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231000849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000850 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231000851 FeS/SAM binding site; other site 243231000852 Phosphopantetheine attachment site; Region: PP-binding; cl09936 243231000853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243231000854 putative acyl-acceptor binding pocket; other site 243231000855 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 243231000856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000857 FeS/SAM binding site; other site 243231000858 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 243231000859 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231000860 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243231000861 Ligand binding site; other site 243231000862 Putative Catalytic site; other site 243231000863 DXD motif; other site 243231000864 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 243231000865 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 243231000866 putative active site [active] 243231000867 putative catalytic site [active] 243231000868 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231000869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000870 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231000871 FeS/SAM binding site; other site 243231000872 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231000873 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 243231000874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000875 FeS/SAM binding site; other site 243231000876 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 243231000877 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 243231000878 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 243231000879 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 243231000880 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231000881 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243231000882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000883 PAS domain; Region: PAS_9; pfam13426 243231000884 putative active site [active] 243231000885 heme pocket [chemical binding]; other site 243231000886 GAF domain; Region: GAF_2; pfam13185 243231000887 PAS domain S-box; Region: sensory_box; TIGR00229 243231000888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000889 putative active site [active] 243231000890 heme pocket [chemical binding]; other site 243231000891 PAS domain S-box; Region: sensory_box; TIGR00229 243231000892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000893 putative active site [active] 243231000894 heme pocket [chemical binding]; other site 243231000895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231000896 Histidine kinase; Region: HisKA_3; pfam07730 243231000897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000898 ATP binding site [chemical binding]; other site 243231000899 Mg2+ binding site [ion binding]; other site 243231000900 G-X-G motif; other site 243231000901 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231000902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231000903 active site 243231000904 phosphorylation site [posttranslational modification] 243231000905 intermolecular recognition site; other site 243231000906 dimerization interface [polypeptide binding]; other site 243231000907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243231000908 DNA binding residues [nucleotide binding] 243231000909 dimerization interface [polypeptide binding]; other site 243231000910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000911 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243231000912 putative active site [active] 243231000913 heme pocket [chemical binding]; other site 243231000914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231000915 putative active site [active] 243231000916 heme pocket [chemical binding]; other site 243231000917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231000918 dimer interface [polypeptide binding]; other site 243231000919 phosphorylation site [posttranslational modification] 243231000920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231000921 ATP binding site [chemical binding]; other site 243231000922 Mg2+ binding site [ion binding]; other site 243231000923 G-X-G motif; other site 243231000924 Hemerythrin; Region: Hemerythrin; cd12107 243231000925 Fe binding site [ion binding]; other site 243231000926 Uncharacterized conserved protein [Function unknown]; Region: COG1359 243231000927 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 243231000928 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 243231000929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243231000930 Ligand Binding Site [chemical binding]; other site 243231000931 putative cation:proton antiport protein; Provisional; Region: PRK10669 243231000932 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 243231000933 TrkA-N domain; Region: TrkA_N; pfam02254 243231000934 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 243231000935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231000936 putative substrate translocation pore; other site 243231000937 Membrane transport protein; Region: Mem_trans; cl09117 243231000938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243231000939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231000940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243231000941 dimerization interface [polypeptide binding]; other site 243231000942 palindrome; GSUR0100 243231000943 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 243231000944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243231000945 DNA-binding site [nucleotide binding]; DNA binding site 243231000946 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 243231000947 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 243231000948 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 243231000949 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 243231000950 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 243231000951 glutaminase active site [active] 243231000952 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 243231000953 dimer interface [polypeptide binding]; other site 243231000954 active site 243231000955 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 243231000956 dimer interface [polypeptide binding]; other site 243231000957 active site 243231000958 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14355 243231000959 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 243231000960 Substrate binding site; other site 243231000961 Mg++ binding site; other site 243231000962 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 243231000963 active site 243231000964 substrate binding site [chemical binding]; other site 243231000965 CoA binding site [chemical binding]; other site 243231000966 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231000967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231000968 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231000969 FeS/SAM binding site; other site 243231000970 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 243231000971 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231000972 heme-binding residues [chemical binding]; other site 243231000973 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 243231000974 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231000975 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231000976 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243231000977 palindrome; GSUR0101 243231000978 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 243231000979 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231000980 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231000981 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231000982 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 243231000983 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243231000984 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 243231000985 Walker A/P-loop; other site 243231000986 ATP binding site [chemical binding]; other site 243231000987 Q-loop/lid; other site 243231000988 ABC transporter signature motif; other site 243231000989 Walker B; other site 243231000990 D-loop; other site 243231000991 H-loop/switch region; other site 243231000992 Outer membrane efflux protein; Region: OEP; pfam02321 243231000993 Outer membrane efflux protein; Region: OEP; pfam02321 243231000994 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231000995 Ca2+ binding site [ion binding]; other site 243231000996 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231000997 Ca2+ binding site [ion binding]; other site 243231000998 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231000999 Ca2+ binding site [ion binding]; other site 243231001000 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231001001 Ca2+ binding site [ion binding]; other site 243231001002 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231001003 Ca2+ binding site [ion binding]; other site 243231001004 Calx-beta domain; Region: Calx-beta; cl02522 243231001005 Calx-beta domain; Region: Calx-beta; cl02522 243231001006 Calx-beta domain; Region: Calx-beta; cl02522 243231001007 Calx-beta domain; Region: Calx-beta; cl02522 243231001008 Calx-beta domain; Region: Calx-beta; cl02522 243231001009 Calx-beta domain; Region: Calx-beta; cl02522 243231001010 Calx-beta domain; Region: Calx-beta; cl02522 243231001011 Calx-beta domain; Region: Calx-beta; cl02522 243231001012 Calx-beta domain; Region: Calx-beta; cl02522 243231001013 Calx-beta domain; Region: Calx-beta; cl02522 243231001014 Calx-beta domain; Region: Calx-beta; cl02522 243231001015 Calx-beta domain; Region: Calx-beta; cl02522 243231001016 Calx-beta domain; Region: Calx-beta; cl02522 243231001017 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 243231001018 Calx-beta domain; Region: Calx-beta; cl02522 243231001019 Calx-beta domain; Region: Calx-beta; cl02522 243231001020 Calx-beta domain; Region: Calx-beta; cl02522 243231001021 Calx-beta domain; Region: Calx-beta; cl02522 243231001022 Calx-beta domain; Region: Calx-beta; cl02522 243231001023 Calx-beta domain; Region: Calx-beta; cl02522 243231001024 Calx-beta domain; Region: Calx-beta; cl02522 243231001025 Calx-beta domain; Region: Calx-beta; cl02522 243231001026 Calx-beta domain; Region: Calx-beta; cl02522 243231001027 Calx-beta domain; Region: Calx-beta; cl02522 243231001028 Calx-beta domain; Region: Calx-beta; cl02522 243231001029 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231001030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001031 active site 243231001032 phosphorylation site [posttranslational modification] 243231001033 intermolecular recognition site; other site 243231001034 dimerization interface [polypeptide binding]; other site 243231001035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001036 Walker A motif; other site 243231001037 ATP binding site [chemical binding]; other site 243231001038 Walker B motif; other site 243231001039 arginine finger; other site 243231001040 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231001041 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231001042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001043 dimer interface [polypeptide binding]; other site 243231001044 phosphorylation site [posttranslational modification] 243231001045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001046 ATP binding site [chemical binding]; other site 243231001047 Mg2+ binding site [ion binding]; other site 243231001048 G-X-G motif; other site 243231001049 GAF domain; Region: GAF_3; pfam13492 243231001050 GAF domain; Region: GAF; pfam01590 243231001051 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231001052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001053 dimer interface [polypeptide binding]; other site 243231001054 phosphorylation site [posttranslational modification] 243231001055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001056 ATP binding site [chemical binding]; other site 243231001057 Mg2+ binding site [ion binding]; other site 243231001058 G-X-G motif; other site 243231001059 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 243231001060 DNA repair protein RadA; Provisional; Region: PRK11823 243231001061 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 243231001062 Walker A motif/ATP binding site; other site 243231001063 ATP binding site [chemical binding]; other site 243231001064 Walker B motif; other site 243231001065 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243231001066 HEAT repeats; Region: HEAT_2; pfam13646 243231001067 HEAT repeats; Region: HEAT_2; pfam13646 243231001068 YCII-related domain; Region: YCII; cl00999 243231001069 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231001070 Zn2+ binding site [ion binding]; other site 243231001071 Mg2+ binding site [ion binding]; other site 243231001072 HEAT repeats; Region: HEAT_2; pfam13646 243231001073 HEAT repeats; Region: HEAT_2; pfam13646 243231001074 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243231001075 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243231001076 dimer interface [polypeptide binding]; other site 243231001077 active site 243231001078 CoA binding pocket [chemical binding]; other site 243231001079 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 243231001080 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 243231001081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001082 active site 243231001083 phosphorylation site [posttranslational modification] 243231001084 intermolecular recognition site; other site 243231001085 dimerization interface [polypeptide binding]; other site 243231001086 CheB methylesterase; Region: CheB_methylest; pfam01339 243231001087 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 243231001088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231001089 Zn2+ binding site [ion binding]; other site 243231001090 Mg2+ binding site [ion binding]; other site 243231001091 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243231001092 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243231001093 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 243231001094 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 243231001095 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243231001096 putative binding surface; other site 243231001097 active site 243231001098 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 243231001099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001100 ATP binding site [chemical binding]; other site 243231001101 Mg2+ binding site [ion binding]; other site 243231001102 G-X-G motif; other site 243231001103 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 243231001104 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231001105 putative CheA interaction surface; other site 243231001106 conserved nucleotide sequence; similar to other Geobacter species; GSUR0102 243231001107 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 243231001108 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231001109 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243231001110 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243231001111 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243231001112 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243231001113 catalytic residue [active] 243231001114 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243231001115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001116 dimerization interface [polypeptide binding]; other site 243231001117 PAS domain S-box; Region: sensory_box; TIGR00229 243231001118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231001119 putative active site [active] 243231001120 heme pocket [chemical binding]; other site 243231001121 aminopeptidase N; Provisional; Region: pepN; PRK14015 243231001122 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 243231001123 active site 243231001124 Zn binding site [ion binding]; other site 243231001125 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231001126 Acylphosphatase; Region: Acylphosphatase; pfam00708 243231001127 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 243231001128 HypF finger; Region: zf-HYPF; pfam07503 243231001129 HypF finger; Region: zf-HYPF; pfam07503 243231001130 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 243231001131 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 243231001132 HupF/HypC family; Region: HupF_HypC; pfam01455 243231001133 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 243231001134 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 243231001135 dimerization interface [polypeptide binding]; other site 243231001136 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 243231001137 ATP binding site [chemical binding]; other site 243231001138 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 243231001139 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 243231001140 active site 243231001141 nucleophile elbow; other site 243231001142 PilZ domain; Region: PilZ; pfam07238 243231001143 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243231001144 HSP70 interaction site [polypeptide binding]; other site 243231001145 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231001146 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 243231001147 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 243231001148 Peptidase family M48; Region: Peptidase_M48; pfam01435 243231001149 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243231001150 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 243231001151 GspL periplasmic domain; Region: GspL_C; cl14909 243231001152 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 243231001153 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 243231001154 type II secretion system protein J; Region: gspJ; TIGR01711 243231001155 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 243231001156 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243231001157 type II secretion system protein I; Region: gspI; TIGR01707 243231001158 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 243231001159 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 243231001160 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 243231001161 type II secretion system protein F; Region: GspF; TIGR02120 243231001162 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243231001163 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243231001164 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231001165 type II secretion system protein E; Region: type_II_gspE; TIGR02533 243231001166 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243231001167 Walker A motif; other site 243231001168 ATP binding site [chemical binding]; other site 243231001169 Walker B motif; other site 243231001170 type II secretion system protein D; Region: type_II_gspD; TIGR02517 243231001171 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243231001172 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243231001173 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243231001174 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243231001175 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 243231001176 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 243231001177 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243231001178 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 243231001179 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 243231001180 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243231001181 protein binding site [polypeptide binding]; other site 243231001182 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 243231001183 protein binding site [polypeptide binding]; other site 243231001184 multifunctional aminopeptidase A; Provisional; Region: PRK00913 243231001185 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243231001186 interface (dimer of trimers) [polypeptide binding]; other site 243231001187 Substrate-binding/catalytic site; other site 243231001188 Zn-binding sites [ion binding]; other site 243231001189 ATP synthase subunit C; Region: ATP-synt_C; cl00466 243231001190 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 243231001191 ATP synthase I chain; Region: ATP_synt_I; pfam03899 243231001192 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 243231001193 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 243231001194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243231001195 inhibitor-cofactor binding pocket; inhibition site 243231001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231001197 catalytic residue [active] 243231001198 conserved nucleotide sequence; similar to other Geobacter species; GSUR0103 243231001199 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 243231001200 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243231001201 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 243231001202 NADH dehydrogenase subunit D; Validated; Region: PRK06075 243231001203 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 243231001204 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 243231001205 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243231001206 putative dimer interface [polypeptide binding]; other site 243231001207 [2Fe-2S] cluster binding site [ion binding]; other site 243231001208 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243231001209 dimer interface [polypeptide binding]; other site 243231001210 [2Fe-2S] cluster binding site [ion binding]; other site 243231001211 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243231001212 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 243231001213 SLBB domain; Region: SLBB; pfam10531 243231001214 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 243231001215 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231001216 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231001217 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 243231001218 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243231001219 catalytic loop [active] 243231001220 iron binding site [ion binding]; other site 243231001221 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243231001222 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231001223 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 243231001224 [4Fe-4S] binding site [ion binding]; other site 243231001225 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 243231001226 molybdopterin cofactor binding site; other site 243231001227 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 243231001228 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 243231001229 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231001230 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 243231001231 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 243231001232 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 243231001233 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243231001234 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231001235 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 243231001236 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243231001237 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231001238 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 243231001239 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231001240 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 243231001241 dimer interface [polypeptide binding]; other site 243231001242 catalytic triad [active] 243231001243 peroxidatic and resolving cysteines [active] 243231001244 Predicted membrane protein [Function unknown]; Region: COG1238 243231001245 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 243231001246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243231001247 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243231001248 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001249 dimer interface [polypeptide binding]; other site 243231001250 phosphorylation site [posttranslational modification] 243231001251 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001252 ATP binding site [chemical binding]; other site 243231001253 Mg2+ binding site [ion binding]; other site 243231001254 G-X-G motif; other site 243231001255 Cytochrome c7; Region: Cytochrome_C7; cl19206 243231001256 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231001257 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243231001258 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231001259 PAS domain; Region: PAS_10; pfam13596 243231001260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231001261 putative active site [active] 243231001262 heme pocket [chemical binding]; other site 243231001263 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243231001264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001265 Walker A motif; other site 243231001266 ATP binding site [chemical binding]; other site 243231001267 Walker B motif; other site 243231001268 arginine finger; other site 243231001269 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231001270 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 243231001271 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231001272 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231001273 ligand binding site [chemical binding]; other site 243231001274 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 243231001275 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243231001276 conserved nucleotide sequence; similar to other Geobacter species; GSUR0104 243231001277 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 243231001278 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 243231001279 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 243231001280 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 243231001281 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231001282 heme-binding residues [chemical binding]; other site 243231001283 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231001284 heme-binding residues [chemical binding]; other site 243231001285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243231001286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231001287 non-specific DNA binding site [nucleotide binding]; other site 243231001288 salt bridge; other site 243231001289 sequence-specific DNA binding site [nucleotide binding]; other site 243231001290 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 243231001291 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243231001292 Surface antigen; Region: Bac_surface_Ag; pfam01103 243231001293 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 243231001294 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 243231001295 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 243231001296 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 243231001297 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 243231001298 putative homodimer interface [polypeptide binding]; other site 243231001299 putative active site pocket [active] 243231001300 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 243231001301 conserved nucleotide sequence; similar to other Geobacter species; GSUR0105 243231001302 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231001303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001304 active site 243231001305 phosphorylation site [posttranslational modification] 243231001306 intermolecular recognition site; other site 243231001307 dimerization interface [polypeptide binding]; other site 243231001308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001309 Walker A motif; other site 243231001310 ATP binding site [chemical binding]; other site 243231001311 Walker B motif; other site 243231001312 arginine finger; other site 243231001313 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231001314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231001315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001316 dimerization interface [polypeptide binding]; other site 243231001317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001318 dimer interface [polypeptide binding]; other site 243231001319 phosphorylation site [posttranslational modification] 243231001320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001321 ATP binding site [chemical binding]; other site 243231001322 Mg2+ binding site [ion binding]; other site 243231001323 G-X-G motif; other site 243231001324 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 243231001325 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 243231001326 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 243231001327 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 243231001328 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243231001329 lipoyl attachment site [posttranslational modification]; other site 243231001330 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 243231001331 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231001332 catalytic residue [active] 243231001333 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 243231001334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231001335 catalytic residue [active] 243231001336 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243231001337 lipoyl synthase; Provisional; Region: PRK05481 243231001338 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 243231001339 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243231001340 OsmC-like protein; Region: OsmC; pfam02566 243231001341 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243231001342 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 243231001343 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231001344 diiron binding motif [ion binding]; other site 243231001345 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 243231001346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231001347 NAD(P) binding site [chemical binding]; other site 243231001348 active site 243231001349 hypothetical protein; Reviewed; Region: PRK00024 243231001350 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 243231001351 MPN+ (JAMM) motif; other site 243231001352 Zinc-binding site [ion binding]; other site 243231001353 Bacitracin resistance protein BacA; Region: BacA; pfam02673 243231001354 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 243231001355 TIGR00153 family protein; Region: TIGR00153 243231001356 Phosphate transporter family; Region: PHO4; pfam01384 243231001357 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 243231001358 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243231001359 Outer membrane efflux protein; Region: OEP; pfam02321 243231001360 Outer membrane efflux protein; Region: OEP; pfam02321 243231001361 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243231001362 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231001363 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243231001364 MMPL family; Region: MMPL; cl14618 243231001365 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 243231001366 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 243231001367 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 243231001368 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231001369 active site residue [active] 243231001370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243231001371 dimerization interface [polypeptide binding]; other site 243231001372 putative DNA binding site [nucleotide binding]; other site 243231001373 putative Zn2+ binding site [ion binding]; other site 243231001374 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243231001375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001376 dimerization interface [polypeptide binding]; other site 243231001377 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231001378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231001379 dimer interface [polypeptide binding]; other site 243231001380 putative CheW interface [polypeptide binding]; other site 243231001381 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231001382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001383 dimerization interface [polypeptide binding]; other site 243231001384 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231001385 dimer interface [polypeptide binding]; other site 243231001386 putative CheW interface [polypeptide binding]; other site 243231001387 Hemerythrin; Region: Hemerythrin; cd12107 243231001388 Fe binding site [ion binding]; other site 243231001389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001390 active site 243231001391 phosphorylation site [posttranslational modification] 243231001392 intermolecular recognition site; other site 243231001393 dimerization interface [polypeptide binding]; other site 243231001394 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 243231001395 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231001396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001397 active site 243231001398 phosphorylation site [posttranslational modification] 243231001399 dimerization interface [polypeptide binding]; other site 243231001400 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243231001401 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243231001402 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 243231001403 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 243231001404 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 243231001405 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 243231001406 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243231001407 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243231001408 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 243231001409 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 243231001410 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 243231001411 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 243231001412 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 243231001413 FliG N-terminal domain; Region: FliG_N; pfam14842 243231001414 FliG middle domain; Region: FliG_M; pfam14841 243231001415 FliG C-terminal domain; Region: FliG_C; pfam01706 243231001416 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 243231001417 Flagellar assembly protein FliH; Region: FliH; pfam02108 243231001418 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 243231001419 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243231001420 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 243231001421 Walker A motif/ATP binding site; other site 243231001422 Walker B motif; other site 243231001423 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 243231001424 Uncharacterized conserved protein [Function unknown]; Region: COG3334 243231001425 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 243231001426 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 243231001427 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 243231001428 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 243231001429 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 243231001430 conserved nucleotide sequence; similar to other Geobacter species; GSUR0106 243231001431 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 243231001432 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243231001433 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 243231001434 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243231001435 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 243231001436 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 243231001437 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 243231001438 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 243231001439 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 243231001440 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 243231001441 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 243231001442 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 243231001443 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 243231001444 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 243231001445 Bacterial SH3 domain; Region: SH3_3; pfam08239 243231001446 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 243231001447 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 243231001448 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 243231001449 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 243231001450 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 243231001451 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 243231001452 Clp amino terminal domain; Region: Clp_N; pfam02861 243231001453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001454 Walker A motif; other site 243231001455 ATP binding site [chemical binding]; other site 243231001456 Walker B motif; other site 243231001457 arginine finger; other site 243231001458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001459 Walker A motif; other site 243231001460 ATP binding site [chemical binding]; other site 243231001461 Walker B motif; other site 243231001462 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243231001463 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 243231001464 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 243231001465 Ligand Binding Site [chemical binding]; other site 243231001466 conserved nucleotide sequence; similar to other Geobacter species; GSUR0107 243231001467 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231001468 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 243231001469 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243231001470 Walker A motif; other site 243231001471 ATP binding site [chemical binding]; other site 243231001472 Walker B motif; other site 243231001473 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243231001474 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 243231001475 Walker A motif; other site 243231001476 ATP binding site [chemical binding]; other site 243231001477 Walker B motif; other site 243231001478 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 243231001479 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 243231001480 putative active site [active] 243231001481 aromatic acid decarboxylase; Validated; Region: PRK05920 243231001482 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 243231001483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231001484 FeS/SAM binding site; other site 243231001485 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 243231001486 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243231001487 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 243231001488 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 243231001489 catalytic site [active] 243231001490 putative active site [active] 243231001491 putative substrate binding site [chemical binding]; other site 243231001492 HRDC domain; Region: HRDC; pfam00570 243231001493 HRDC domain; Region: HRDC; pfam00570 243231001494 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 243231001495 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 243231001496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243231001497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231001498 S-adenosylmethionine binding site [chemical binding]; other site 243231001499 conserved nucleotide sequence; similar to other Geobacter species; GSUR0108 243231001500 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 243231001501 amidohydrolase; Region: amidohydrolases; TIGR01891 243231001502 metal binding site [ion binding]; metal-binding site 243231001503 PEP synthetase regulatory protein; Provisional; Region: PRK05339 243231001504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231001505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001506 active site 243231001507 phosphorylation site [posttranslational modification] 243231001508 intermolecular recognition site; other site 243231001509 dimerization interface [polypeptide binding]; other site 243231001510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231001511 DNA binding site [nucleotide binding] 243231001512 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 243231001513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001514 dimerization interface [polypeptide binding]; other site 243231001515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001516 dimer interface [polypeptide binding]; other site 243231001517 phosphorylation site [posttranslational modification] 243231001518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001519 ATP binding site [chemical binding]; other site 243231001520 Mg2+ binding site [ion binding]; other site 243231001521 G-X-G motif; other site 243231001522 futalosine nucleosidase; Region: fut_nucase; TIGR03664 243231001523 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 243231001524 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 243231001525 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243231001526 MMPL family; Region: MMPL; cl14618 243231001527 MMPL family; Region: MMPL; cl14618 243231001528 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 243231001529 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 243231001530 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 243231001531 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 243231001532 active site 2 [active] 243231001533 active site 1 [active] 243231001534 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243231001535 active site 243231001536 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243231001537 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243231001538 dimer interface [polypeptide binding]; other site 243231001539 active site 243231001540 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243231001541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231001542 NAD(P) binding site [chemical binding]; other site 243231001543 active site 243231001544 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 243231001545 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243231001546 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 243231001547 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231001548 RNA binding surface [nucleotide binding]; other site 243231001549 elongation factor P; Provisional; Region: PRK14578 243231001550 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243231001551 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243231001552 RNA binding site [nucleotide binding]; other site 243231001553 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243231001554 RNA binding site [nucleotide binding]; other site 243231001555 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 243231001556 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243231001557 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 243231001558 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231001559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001560 active site 243231001561 phosphorylation site [posttranslational modification] 243231001562 intermolecular recognition site; other site 243231001563 dimerization interface [polypeptide binding]; other site 243231001564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001565 Walker A motif; other site 243231001566 ATP binding site [chemical binding]; other site 243231001567 Walker B motif; other site 243231001568 arginine finger; other site 243231001569 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231001570 sensor protein ZraS; Provisional; Region: PRK10364 243231001571 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 243231001572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001573 dimer interface [polypeptide binding]; other site 243231001574 phosphorylation site [posttranslational modification] 243231001575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001576 ATP binding site [chemical binding]; other site 243231001577 Mg2+ binding site [ion binding]; other site 243231001578 G-X-G motif; other site 243231001579 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 243231001580 putative hydrophobic ligand binding site [chemical binding]; other site 243231001581 Predicted transcriptional regulator [Transcription]; Region: COG2378 243231001582 HTH domain; Region: HTH_11; pfam08279 243231001583 WYL domain; Region: WYL; pfam13280 243231001584 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 243231001585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231001586 putative active site [active] 243231001587 heme pocket [chemical binding]; other site 243231001588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231001589 putative active site [active] 243231001590 heme pocket [chemical binding]; other site 243231001591 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231001592 metal binding site [ion binding]; metal-binding site 243231001593 active site 243231001594 I-site; other site 243231001595 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231001596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231001597 putative active site [active] 243231001598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231001599 heme pocket [chemical binding]; other site 243231001600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231001601 dimer interface [polypeptide binding]; other site 243231001602 phosphorylation site [posttranslational modification] 243231001603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231001604 ATP binding site [chemical binding]; other site 243231001605 Mg2+ binding site [ion binding]; other site 243231001606 G-X-G motif; other site 243231001607 Uncharacterized conserved protein [Function unknown]; Region: COG1565 243231001608 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 243231001609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231001610 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 243231001611 active site 243231001612 motif I; other site 243231001613 motif II; other site 243231001614 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231001615 diiron binding motif [ion binding]; other site 243231001616 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 243231001617 Aspartase; Region: Aspartase; cd01357 243231001618 active sites [active] 243231001619 tetramer interface [polypeptide binding]; other site 243231001620 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 243231001621 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 243231001622 PLD-like domain; Region: PLDc_2; pfam13091 243231001623 putative active site [active] 243231001624 catalytic site [active] 243231001625 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 243231001626 PLD-like domain; Region: PLDc_2; pfam13091 243231001627 putative active site [active] 243231001628 catalytic site [active] 243231001629 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 243231001630 Ligand Binding Site [chemical binding]; other site 243231001631 putative GTP cyclohydrolase; Provisional; Region: PRK13674 243231001632 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 243231001633 threonine dehydratase; Provisional; Region: PRK08198 243231001634 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 243231001635 tetramer interface [polypeptide binding]; other site 243231001636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231001637 catalytic residue [active] 243231001638 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 243231001639 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 243231001640 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 243231001641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231001642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231001643 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 243231001644 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 243231001645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231001646 Walker A motif; other site 243231001647 ATP binding site [chemical binding]; other site 243231001648 Walker B motif; other site 243231001649 arginine finger; other site 243231001650 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 243231001651 conserved nucleotide sequence; similar to other Geobacter species; GSUR0109 243231001652 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 243231001653 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 243231001654 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 243231001655 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 243231001656 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243231001657 ATP binding site [chemical binding]; other site 243231001658 Mg++ binding site [ion binding]; other site 243231001659 motif III; other site 243231001660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231001661 nucleotide binding region [chemical binding]; other site 243231001662 ATP-binding site [chemical binding]; other site 243231001663 conserved nucleotide sequence; similar to other Geobacter species; GSUR0110 243231001664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243231001665 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 243231001666 active site 243231001667 DNA binding site [nucleotide binding] 243231001668 Int/Topo IB signature motif; other site 243231001669 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 243231001670 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231001671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231001672 Domain of unknown function (DUF362); Region: DUF362; cl19822 243231001673 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231001674 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 243231001675 conserved nucleotide sequence; similar to other Geobacter species; GSUR0111 243231001676 macrolide transporter subunit MacA; Provisional; Region: PRK11578 243231001677 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231001678 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231001679 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231001680 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231001681 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231001682 Walker A/P-loop; other site 243231001683 ATP binding site [chemical binding]; other site 243231001684 Q-loop/lid; other site 243231001685 ABC transporter signature motif; other site 243231001686 Walker B; other site 243231001687 D-loop; other site 243231001688 H-loop/switch region; other site 243231001689 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231001690 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243231001691 FtsX-like permease family; Region: FtsX; pfam02687 243231001692 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 243231001693 Peptidase family M23; Region: Peptidase_M23; pfam01551 243231001694 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 243231001695 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 243231001696 G1 box; other site 243231001697 putative GEF interaction site [polypeptide binding]; other site 243231001698 GTP/Mg2+ binding site [chemical binding]; other site 243231001699 Switch I region; other site 243231001700 G2 box; other site 243231001701 G3 box; other site 243231001702 Switch II region; other site 243231001703 G4 box; other site 243231001704 G5 box; other site 243231001705 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 243231001706 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 243231001707 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 243231001708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231001709 binding surface 243231001710 TPR motif; other site 243231001711 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 243231001712 camphor resistance protein CrcB; Provisional; Region: PRK14222 243231001713 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 243231001714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231001715 active site residue [active] 243231001716 Methylamine utilisation protein MauE; Region: MauE; pfam07291 243231001717 membrane protein; Provisional; Region: PRK14393 243231001718 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 243231001719 dimerization interface [polypeptide binding]; other site 243231001720 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 243231001721 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243231001722 catalytic loop [active] 243231001723 iron binding site [ion binding]; other site 243231001724 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243231001725 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243231001726 molybdopterin cofactor binding site; other site 243231001727 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 243231001728 molybdopterin cofactor binding site; other site 243231001729 conserved nucleotide sequence; similar to other Geobacter species; GSUR0112 243231001730 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 243231001731 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 243231001732 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 243231001733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231001734 Protein of unknown function TPD sequence-motif; Region: TPD; pfam14811 243231001735 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231001736 conserved nucleotide sequence; similar to other Geobacter species; GSUR0113 243231001737 Thermophilic metalloprotease (M29); Region: Peptidase_M29; cl19596 243231001738 Protein of unknown function (DUF342); Region: DUF342; pfam03961 243231001739 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 243231001740 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243231001741 CoA-binding site [chemical binding]; other site 243231001742 ATP-binding [chemical binding]; other site 243231001743 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243231001744 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243231001745 Bacterial transcriptional regulator; Region: IclR; pfam01614 243231001746 conserved nucleotide sequence; similar to other Geobacter species; GSUR0114 243231001747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243231001748 Ligand Binding Site [chemical binding]; other site 243231001749 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243231001750 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243231001751 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243231001752 metal binding triad; other site 243231001753 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 243231001754 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243231001755 Na binding site [ion binding]; other site 243231001756 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 243231001757 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 243231001758 active site 243231001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231001760 S-adenosylmethionine binding site [chemical binding]; other site 243231001761 major capsid protein; Region: PHA00201 243231001762 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 243231001763 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243231001764 ATP binding site [chemical binding]; other site 243231001765 Mg++ binding site [ion binding]; other site 243231001766 motif III; other site 243231001767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231001768 nucleotide binding region [chemical binding]; other site 243231001769 ATP-binding site [chemical binding]; other site 243231001770 aminodeoxychorismate synthase; Provisional; Region: PRK07508 243231001771 chorismate binding enzyme; Region: Chorismate_bind; cl10555 243231001772 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 243231001773 substrate-cofactor binding pocket; other site 243231001774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231001775 homodimer interface [polypeptide binding]; other site 243231001776 catalytic residue [active] 243231001777 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 243231001778 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 243231001779 putative active site [active] 243231001780 dimerization interface [polypeptide binding]; other site 243231001781 putative tRNAtyr binding site [nucleotide binding]; other site 243231001782 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 243231001783 putative ADP-ribose binding site [chemical binding]; other site 243231001784 putative active site [active] 243231001785 Ion channel; Region: Ion_trans_2; pfam07885 243231001786 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243231001787 TrkA-N domain; Region: TrkA_N; pfam02254 243231001788 TrkA-C domain; Region: TrkA_C; pfam02080 243231001789 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243231001790 TrkA-N domain; Region: TrkA_N; pfam02254 243231001791 TrkA-C domain; Region: TrkA_C; pfam02080 243231001792 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231001793 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243231001794 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 243231001795 putative FMN binding site [chemical binding]; other site 243231001796 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 243231001797 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 243231001798 AP (apurinic/apyrimidinic) site pocket; other site 243231001799 DNA interaction; other site 243231001800 Metal-binding active site; metal-binding site 243231001801 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 243231001802 nucleotide binding site/active site [active] 243231001803 HIT family signature motif; other site 243231001804 catalytic residue [active] 243231001805 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 243231001806 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243231001807 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 243231001808 Predicted transcriptional regulator [Transcription]; Region: COG1959 243231001809 Rrf2 family protein; Region: rrf2_super; TIGR00738 243231001810 cysteine synthase; Region: PLN02565 243231001811 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243231001812 dimer interface [polypeptide binding]; other site 243231001813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231001814 catalytic residue [active] 243231001815 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 243231001816 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 243231001817 Ligand Binding Site [chemical binding]; other site 243231001818 GAF domain; Region: GAF; pfam01590 243231001819 PAS fold; Region: PAS_4; pfam08448 243231001820 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231001821 putative active site [active] 243231001822 heme pocket [chemical binding]; other site 243231001823 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231001824 metal binding site [ion binding]; metal-binding site 243231001825 active site 243231001826 I-site; other site 243231001827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231001828 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243231001829 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243231001830 putative dimer interface [polypeptide binding]; other site 243231001831 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 243231001832 DNA polymerase I; Provisional; Region: PRK05755 243231001833 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243231001834 active site 243231001835 metal binding site 1 [ion binding]; metal-binding site 243231001836 putative 5' ssDNA interaction site; other site 243231001837 metal binding site 3; metal-binding site 243231001838 metal binding site 2 [ion binding]; metal-binding site 243231001839 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243231001840 putative DNA binding site [nucleotide binding]; other site 243231001841 putative metal binding site [ion binding]; other site 243231001842 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 243231001843 active site 243231001844 catalytic site [active] 243231001845 substrate binding site [chemical binding]; other site 243231001846 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 243231001847 active site 243231001848 DNA binding site [nucleotide binding] 243231001849 catalytic site [active] 243231001850 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231001851 metal binding site [ion binding]; metal-binding site 243231001852 active site 243231001853 I-site; other site 243231001854 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 243231001855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231001856 S-adenosylmethionine binding site [chemical binding]; other site 243231001857 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243231001858 EamA-like transporter family; Region: EamA; pfam00892 243231001859 EamA-like transporter family; Region: EamA; pfam00892 243231001860 RF-1 domain; Region: RF-1; pfam00472 243231001861 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 243231001862 MutS domain III; Region: MutS_III; pfam05192 243231001863 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 243231001864 Walker A/P-loop; other site 243231001865 ATP binding site [chemical binding]; other site 243231001866 Q-loop/lid; other site 243231001867 ABC transporter signature motif; other site 243231001868 Walker B; other site 243231001869 D-loop; other site 243231001870 H-loop/switch region; other site 243231001871 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 243231001872 Smr domain; Region: Smr; pfam01713 243231001873 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 243231001874 B12 binding domain; Region: B12-binding; pfam02310 243231001875 B12 binding site [chemical binding]; other site 243231001876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231001877 FeS/SAM binding site; other site 243231001878 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 243231001879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231001880 S-adenosylmethionine binding site [chemical binding]; other site 243231001881 Predicted transcriptional regulator [Transcription]; Region: COG4190 243231001882 Helix-turn-helix domain; Region: HTH_20; pfam12840 243231001883 conserved nucleotide sequence; similar to other Geobacter species; GSUR0115 243231001884 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 243231001885 putative active site [active] 243231001886 putative NTP binding site [chemical binding]; other site 243231001887 putative nucleic acid binding site [nucleotide binding]; other site 243231001888 TIR domain; Region: TIR_2; pfam13676 243231001889 Transposase; Region: HTH_Tnp_1; cl17663 243231001890 putative transposase OrfB; Reviewed; Region: PHA02517 243231001891 HTH-like domain; Region: HTH_21; pfam13276 243231001892 Integrase core domain; Region: rve; pfam00665 243231001893 Integrase core domain; Region: rve_3; cl15866 243231001894 conserved nucleotide sequence; similar to other Geobacter species; GSUR0116 243231001895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243231001896 conserved nucleotide sequence; similar to other Geobacter species; GSUR0117 243231001897 Transposase domain (DUF772); Region: DUF772; pfam05598 243231001898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231001899 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243231001900 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243231001901 RibD C-terminal domain; Region: RibD_C; cl17279 243231001902 conserved nucleotide sequence; similar to other Geobacter species; GSUR0118 243231001903 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243231001904 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888; cl19729 243231001905 Double zinc ribbon; Region: DZR; pfam12773 243231001906 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243231001907 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243231001908 catalytic residues [active] 243231001909 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 243231001910 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 243231001911 catalytic triad [active] 243231001912 conserved cis-peptide bond; other site 243231001913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231001914 S-adenosylmethionine binding site [chemical binding]; other site 243231001915 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 243231001916 folate binding site [chemical binding]; other site 243231001917 NADP+ binding site [chemical binding]; other site 243231001918 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 243231001919 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 243231001920 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 243231001921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231001922 motif II; other site 243231001923 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243231001924 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 243231001925 putative NAD(P) binding site [chemical binding]; other site 243231001926 putative substrate binding site [chemical binding]; other site 243231001927 catalytic Zn binding site [ion binding]; other site 243231001928 structural Zn binding site [ion binding]; other site 243231001929 EamA-like transporter family; Region: EamA; pfam00892 243231001930 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 243231001931 EamA-like transporter family; Region: EamA; pfam00892 243231001932 Carbon starvation protein CstA; Region: CstA; pfam02554 243231001933 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 243231001934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231001935 binding surface 243231001936 TPR motif; other site 243231001937 TPR repeat; Region: TPR_11; pfam13414 243231001938 Recombination protein O N terminal; Region: RecO_N; pfam11967 243231001939 DNA repair protein RecO; Region: reco; TIGR00613 243231001940 Recombination protein O C terminal; Region: RecO_C; pfam02565 243231001941 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 243231001942 dimer interface [polypeptide binding]; other site 243231001943 motif 1; other site 243231001944 active site 243231001945 motif 2; other site 243231001946 motif 3; other site 243231001947 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 243231001948 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 243231001949 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243231001950 pyruvate phosphate dikinase; Provisional; Region: PRK09279 243231001951 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243231001952 Class I aldolases; Region: Aldolase_Class_I; cl17187 243231001953 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243231001954 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243231001955 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243231001956 DNA-binding site [nucleotide binding]; DNA binding site 243231001957 RNA-binding motif; other site 243231001958 conserved palindrome; GSUR0119 243231001959 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231001960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001961 dimerization interface [polypeptide binding]; other site 243231001962 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231001963 dimer interface [polypeptide binding]; other site 243231001964 putative CheW interface [polypeptide binding]; other site 243231001965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001966 dimerization interface [polypeptide binding]; other site 243231001967 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231001968 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231001969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231001970 dimer interface [polypeptide binding]; other site 243231001971 putative CheW interface [polypeptide binding]; other site 243231001972 conserved nucleotide sequence; similar to other Geobacter species; GSUR0061 243231001973 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 243231001974 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 243231001975 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 243231001976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231001977 FeS/SAM binding site; other site 243231001978 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243231001979 thiamine phosphate binding site [chemical binding]; other site 243231001980 active site 243231001981 pyrophosphate binding site [ion binding]; other site 243231001982 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 243231001983 ThiS interaction site; other site 243231001984 putative active site [active] 243231001985 tetramer interface [polypeptide binding]; other site 243231001986 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 243231001987 thiS-thiF/thiG interaction site; other site 243231001988 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243231001989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231001990 dimerization interface [polypeptide binding]; other site 243231001991 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231001992 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231001993 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231001994 heme-binding residues [chemical binding]; other site 243231001995 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243231001996 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231001997 heme-binding residues [chemical binding]; other site 243231001998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231001999 active site 243231002000 phosphorylation site [posttranslational modification] 243231002001 intermolecular recognition site; other site 243231002002 dimerization interface [polypeptide binding]; other site 243231002003 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002005 active site 243231002006 phosphorylation site [posttranslational modification] 243231002007 intermolecular recognition site; other site 243231002008 dimerization interface [polypeptide binding]; other site 243231002009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002010 Walker A motif; other site 243231002011 ATP binding site [chemical binding]; other site 243231002012 Walker B motif; other site 243231002013 arginine finger; other site 243231002014 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243231002015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231002016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002017 dimerization interface [polypeptide binding]; other site 243231002018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002019 dimer interface [polypeptide binding]; other site 243231002020 phosphorylation site [posttranslational modification] 243231002021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002022 ATP binding site [chemical binding]; other site 243231002023 Mg2+ binding site [ion binding]; other site 243231002024 G-X-G motif; other site 243231002025 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243231002026 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 243231002027 active site 243231002028 catalytic site [active] 243231002029 Glucose-regulated metallo-peptidase M90; Region: Peptidase_M90; pfam06167 243231002030 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 243231002031 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 243231002032 thiamine phosphate binding site [chemical binding]; other site 243231002033 active site 243231002034 pyrophosphate binding site [ion binding]; other site 243231002035 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 243231002036 dimer interface [polypeptide binding]; other site 243231002037 substrate binding site [chemical binding]; other site 243231002038 ATP binding site [chemical binding]; other site 243231002039 alanine racemase; Reviewed; Region: alr; PRK00053 243231002040 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 243231002041 active site 243231002042 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243231002043 dimer interface [polypeptide binding]; other site 243231002044 substrate binding site [chemical binding]; other site 243231002045 catalytic residues [active] 243231002046 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 243231002047 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 243231002048 dimerization interface [polypeptide binding]; other site 243231002049 putative ATP binding site [chemical binding]; other site 243231002050 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 243231002051 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 243231002052 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 243231002053 purine monophosphate binding site [chemical binding]; other site 243231002054 dimer interface [polypeptide binding]; other site 243231002055 putative catalytic residues [active] 243231002056 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 243231002057 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 243231002058 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 243231002059 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 243231002060 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 243231002061 AIR carboxylase; Region: AIRC; pfam00731 243231002062 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231002063 heme-binding residues [chemical binding]; other site 243231002064 ResB-like family; Region: ResB; pfam05140 243231002065 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 243231002066 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231002067 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231002068 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231002069 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231002070 Class III cytochrome C family; Region: Cytochrom_CIII; pfam02085 243231002071 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231002072 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231002073 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243231002074 NHL repeat; Region: NHL; pfam01436 243231002075 conserved nucleotide sequence; similar to other Geobacter species; GSUR0120 243231002076 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231002077 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243231002078 active site 243231002079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231002080 TPR motif; other site 243231002081 binding surface 243231002082 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 243231002083 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243231002084 Ligand binding site; other site 243231002085 Putative Catalytic site; other site 243231002086 DXD motif; other site 243231002087 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243231002088 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231002089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 243231002090 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 243231002091 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 243231002092 NADP-binding site; other site 243231002093 homotetramer interface [polypeptide binding]; other site 243231002094 substrate binding site [chemical binding]; other site 243231002095 homodimer interface [polypeptide binding]; other site 243231002096 active site 243231002097 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 243231002098 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 243231002099 NADP binding site [chemical binding]; other site 243231002100 active site 243231002101 putative substrate binding site [chemical binding]; other site 243231002102 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243231002103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002104 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243231002105 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243231002106 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 243231002107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002108 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231002109 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 243231002110 Probable Catalytic site; other site 243231002111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002112 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 243231002113 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 243231002114 Ligand binding site; other site 243231002115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231002116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231002117 Predicted integral membrane protein [Function unknown]; Region: COG5617 243231002118 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243231002119 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 243231002120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002121 S-adenosylmethionine binding site [chemical binding]; other site 243231002122 Protein of unknown function (DUF721); Region: DUF721; pfam05258 243231002123 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 243231002124 signal recognition particle protein; Provisional; Region: PRK10867 243231002125 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243231002126 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243231002127 P loop; other site 243231002128 GTP binding site [chemical binding]; other site 243231002129 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243231002130 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 243231002131 KH domain; Region: KH_4; pfam13083 243231002132 G-X-X-G motif; other site 243231002133 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 243231002134 RimM N-terminal domain; Region: RimM; pfam01782 243231002135 PRC-barrel domain; Region: PRC; pfam05239 243231002136 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 243231002137 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 243231002138 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243231002139 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 243231002140 RNA/DNA hybrid binding site [nucleotide binding]; other site 243231002141 active site 243231002142 hypothetical protein; Provisional; Region: PRK14675 243231002143 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 243231002144 putative active site [active] 243231002145 catalytic triad [active] 243231002146 putative dimer interface [polypeptide binding]; other site 243231002147 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243231002148 homodimer interface [polypeptide binding]; other site 243231002149 NAD binding pocket [chemical binding]; other site 243231002150 ATP binding pocket [chemical binding]; other site 243231002151 Mg binding site [ion binding]; other site 243231002152 active-site loop [active] 243231002153 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 243231002154 putative SAM binding site [chemical binding]; other site 243231002155 putative homodimer interface [polypeptide binding]; other site 243231002156 trRNA_1; GSUR0064 243231002157 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 243231002158 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243231002159 ATP binding site [chemical binding]; other site 243231002160 substrate interface [chemical binding]; other site 243231002161 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243231002162 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 243231002163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243231002164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243231002165 DNA binding residues [nucleotide binding] 243231002166 conserved nucleotide sequence; similar to other Geobacter species; GSUR0121 243231002167 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 243231002168 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 243231002169 homodimer interface [polypeptide binding]; other site 243231002170 substrate-cofactor binding pocket; other site 243231002171 catalytic residue [active] 243231002172 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 243231002173 Clp amino terminal domain; Region: Clp_N; pfam02861 243231002174 Clp amino terminal domain; Region: Clp_N; pfam02861 243231002175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002176 Walker A motif; other site 243231002177 ATP binding site [chemical binding]; other site 243231002178 Walker B motif; other site 243231002179 arginine finger; other site 243231002180 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 243231002181 linker region; other site 243231002182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002183 Walker A motif; other site 243231002184 ATP binding site [chemical binding]; other site 243231002185 Walker B motif; other site 243231002186 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243231002187 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 243231002188 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 243231002189 NodB motif; other site 243231002190 putative active site [active] 243231002191 putative catalytic site [active] 243231002192 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14614 243231002193 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 243231002194 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 243231002195 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 243231002196 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243231002197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231002198 active site 243231002199 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 243231002200 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 243231002201 5S rRNA interface [nucleotide binding]; other site 243231002202 CTC domain interface [polypeptide binding]; other site 243231002203 L16 interface [polypeptide binding]; other site 243231002204 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 243231002205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243231002206 putative active site [active] 243231002207 catalytic residue [active] 243231002208 GTP-binding protein YchF; Reviewed; Region: PRK09601 243231002209 YchF GTPase; Region: YchF; cd01900 243231002210 G1 box; other site 243231002211 GTP/Mg2+ binding site [chemical binding]; other site 243231002212 Switch I region; other site 243231002213 G2 box; other site 243231002214 Switch II region; other site 243231002215 G3 box; other site 243231002216 G4 box; other site 243231002217 G5 box; other site 243231002218 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 243231002219 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 243231002220 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 243231002221 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 243231002222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 243231002223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243231002224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243231002225 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231002226 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 243231002227 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243231002228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231002229 RNA binding surface [nucleotide binding]; other site 243231002230 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243231002231 active site 243231002232 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 243231002233 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 243231002234 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 243231002235 cubane metal cluster [ion binding]; other site 243231002236 hybrid metal cluster; other site 243231002237 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243231002238 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231002239 FtsX-like permease family; Region: FtsX; pfam02687 243231002240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231002241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231002242 Walker A/P-loop; other site 243231002243 ATP binding site [chemical binding]; other site 243231002244 Q-loop/lid; other site 243231002245 ABC transporter signature motif; other site 243231002246 Walker B; other site 243231002247 D-loop; other site 243231002248 H-loop/switch region; other site 243231002249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002250 S-adenosylmethionine binding site [chemical binding]; other site 243231002251 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243231002252 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243231002253 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243231002254 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243231002255 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 243231002256 PAS fold; Region: PAS_4; pfam08448 243231002257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243231002258 Histidine kinase; Region: HisKA_3; pfam07730 243231002259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002260 ATP binding site [chemical binding]; other site 243231002261 Mg2+ binding site [ion binding]; other site 243231002262 G-X-G motif; other site 243231002263 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231002264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002265 active site 243231002266 phosphorylation site [posttranslational modification] 243231002267 intermolecular recognition site; other site 243231002268 dimerization interface [polypeptide binding]; other site 243231002269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243231002270 DNA binding residues [nucleotide binding] 243231002271 dimerization interface [polypeptide binding]; other site 243231002272 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243231002273 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231002274 HAMP domain; Region: HAMP; pfam00672 243231002275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231002276 dimer interface [polypeptide binding]; other site 243231002277 putative CheW interface [polypeptide binding]; other site 243231002278 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231002279 putative CheA interaction surface; other site 243231002280 palindrome; GSUR0122 243231002281 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 243231002282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231002283 FeS/SAM binding site; other site 243231002284 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 243231002285 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243231002286 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243231002287 TPP-binding site; other site 243231002288 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243231002289 PYR/PP interface [polypeptide binding]; other site 243231002290 dimer interface [polypeptide binding]; other site 243231002291 TPP binding site [chemical binding]; other site 243231002292 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231002293 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 243231002294 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 243231002295 putative NADP binding site [chemical binding]; other site 243231002296 putative substrate binding site [chemical binding]; other site 243231002297 active site 243231002298 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 243231002299 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 243231002300 Active site cavity [active] 243231002301 catalytic acid [active] 243231002302 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 243231002303 MMPL family; Region: MMPL; cl14618 243231002304 MMPL family; Region: MMPL; cl14618 243231002305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002306 S-adenosylmethionine binding site [chemical binding]; other site 243231002307 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 243231002308 putative rRNA binding site [nucleotide binding]; other site 243231002309 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 243231002310 substrate binding site [chemical binding]; other site 243231002311 ATP binding site [chemical binding]; other site 243231002312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002313 PAS fold; Region: PAS_3; pfam08447 243231002314 putative active site [active] 243231002315 heme pocket [chemical binding]; other site 243231002316 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 243231002317 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002318 putative active site [active] 243231002319 heme pocket [chemical binding]; other site 243231002320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002321 putative active site [active] 243231002322 heme pocket [chemical binding]; other site 243231002323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002324 dimer interface [polypeptide binding]; other site 243231002325 phosphorylation site [posttranslational modification] 243231002326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002327 ATP binding site [chemical binding]; other site 243231002328 Mg2+ binding site [ion binding]; other site 243231002329 G-X-G motif; other site 243231002330 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 243231002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231002332 active site 243231002333 motif I; other site 243231002334 motif II; other site 243231002335 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 243231002336 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 243231002337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231002338 NAD(P) binding site [chemical binding]; other site 243231002339 active site 243231002340 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 243231002341 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243231002342 ligand binding site; other site 243231002343 HEAT repeats; Region: HEAT_2; pfam13646 243231002344 HEAT repeats; Region: HEAT_2; pfam13646 243231002345 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231002346 Zn2+ binding site [ion binding]; other site 243231002347 Mg2+ binding site [ion binding]; other site 243231002348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002349 active site 243231002350 phosphorylation site [posttranslational modification] 243231002351 intermolecular recognition site; other site 243231002352 dimerization interface [polypeptide binding]; other site 243231002353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002354 PAS fold; Region: PAS_3; pfam08447 243231002355 putative active site [active] 243231002356 heme pocket [chemical binding]; other site 243231002357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002358 PAS domain; Region: PAS_9; pfam13426 243231002359 putative active site [active] 243231002360 heme pocket [chemical binding]; other site 243231002361 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243231002362 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243231002363 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231002364 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231002365 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231002366 ResB-like family; Region: ResB; cl09125 243231002367 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243231002368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231002369 D-galactonate transporter; Region: 2A0114; TIGR00893 243231002370 putative substrate translocation pore; other site 243231002371 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 243231002372 conserved nucleotide sequence; similar to other Geobacter species; GSUR0065 243231002373 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 243231002374 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 243231002375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243231002376 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 243231002377 putative catalytic site [active] 243231002378 putative metal binding site [ion binding]; other site 243231002379 putative phosphate binding site [ion binding]; other site 243231002380 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 243231002381 Bacterial SH3 domain; Region: SH3_3; pfam08239 243231002382 Caspase domain; Region: Peptidase_C14; pfam00656 243231002383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002384 PAS domain; Region: PAS_9; pfam13426 243231002385 putative active site [active] 243231002386 heme pocket [chemical binding]; other site 243231002387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002388 dimer interface [polypeptide binding]; other site 243231002389 phosphorylation site [posttranslational modification] 243231002390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002391 ATP binding site [chemical binding]; other site 243231002392 Mg2+ binding site [ion binding]; other site 243231002393 G-X-G motif; other site 243231002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002395 active site 243231002396 phosphorylation site [posttranslational modification] 243231002397 intermolecular recognition site; other site 243231002398 dimerization interface [polypeptide binding]; other site 243231002399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231002400 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243231002401 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 243231002402 non-heme iron binding site [ion binding]; other site 243231002403 tetramer interface [polypeptide binding]; other site 243231002404 RNA polymerase factor sigma-70; Validated; Region: PRK09047 243231002405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243231002406 DNA binding residues [nucleotide binding] 243231002407 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 243231002408 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 243231002409 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 243231002410 CheD chemotactic sensory transduction; Region: CheD; cl00810 243231002411 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 243231002412 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 243231002413 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 243231002414 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 243231002415 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243231002416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231002417 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243231002418 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 243231002419 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 243231002420 Rnk N-terminus; Region: Rnk_N; pfam14760 243231002421 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 243231002422 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243231002423 rod shape-determining protein MreB; Provisional; Region: PRK13930 243231002424 MreB and similar proteins; Region: MreB_like; cd10225 243231002425 nucleotide binding site [chemical binding]; other site 243231002426 Mg binding site [ion binding]; other site 243231002427 putative protofilament interaction site [polypeptide binding]; other site 243231002428 RodZ interaction site [polypeptide binding]; other site 243231002429 hydrogenase 4 subunit B; Validated; Region: PRK06521 243231002430 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231002431 Helix-turn-helix domain; Region: HTH_17; pfam12728 243231002432 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 243231002433 active site 243231002434 phosphorylation site [posttranslational modification] 243231002435 PemK-like protein; Region: PemK; pfam02452 243231002436 hydrogenase 4 subunit B; Validated; Region: PRK06521 243231002437 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231002438 NADH dehydrogenase; Region: NADHdh; cl00469 243231002439 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 243231002440 hydrogenase 4 subunit F; Validated; Region: PRK06458 243231002441 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231002442 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl19197 243231002443 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 243231002444 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 243231002445 conserved nucleotide sequence; similar to other Geobacter species; GSUR7001 243231002446 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 243231002447 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 243231002448 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 243231002449 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231002450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002451 dimerization interface [polypeptide binding]; other site 243231002452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231002453 dimer interface [polypeptide binding]; other site 243231002454 putative CheW interface [polypeptide binding]; other site 243231002455 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 243231002456 H+ Antiporter protein; Region: 2A0121; TIGR00900 243231002457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231002458 putative substrate translocation pore; other site 243231002459 VacJ like lipoprotein; Region: VacJ; cl01073 243231002460 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 243231002461 Peptidase family A21; Region: Peptidase_A21; pfam03566 243231002462 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231002463 Interdomain contacts; other site 243231002464 Cytokine receptor motif; other site 243231002465 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231002466 Interdomain contacts; other site 243231002467 Cytokine receptor motif; other site 243231002468 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231002469 Interdomain contacts; other site 243231002470 Right handed beta helix region; Region: Beta_helix; pfam13229 243231002471 palindrome; GSUR0123 243231002472 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231002473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002474 dimerization interface [polypeptide binding]; other site 243231002475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231002476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231002477 dimer interface [polypeptide binding]; other site 243231002478 putative CheW interface [polypeptide binding]; other site 243231002479 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 243231002480 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 243231002481 Protein of unknown function (DUF554); Region: DUF554; pfam04474 243231002482 conserved nucleotide sequence; similar to other Geobacter species; GSUR0124 243231002483 conserved nucleotide sequence; similar to other Geobacter species; GSUR0125 243231002484 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243231002485 conserved nucleotide sequence; similar to other Geobacter species; GSUR0126 243231002486 putative transposase OrfB; Reviewed; Region: PHA02517 243231002487 HTH-like domain; Region: HTH_21; pfam13276 243231002488 Integrase core domain; Region: rve; pfam00665 243231002489 Integrase core domain; Region: rve_3; cl15866 243231002490 Transposase; Region: HTH_Tnp_1; cl17663 243231002491 AAA domain; Region: AAA_30; pfam13604 243231002492 AAA domain; Region: AAA_11; pfam13086 243231002493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002494 Walker A motif; other site 243231002495 ATP binding site [chemical binding]; other site 243231002496 Walker B motif; other site 243231002497 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243231002498 WYL domain; Region: WYL; cl14852 243231002499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002500 dimerization interface [polypeptide binding]; other site 243231002501 Bacterial protein of unknown function (DUF871); Region: DUF871; cl19843 243231002502 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231002503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231002504 dimer interface [polypeptide binding]; other site 243231002505 putative CheW interface [polypeptide binding]; other site 243231002506 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 243231002507 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 243231002508 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 243231002509 Predicted permeases [General function prediction only]; Region: RarD; COG2962 243231002510 EamA-like transporter family; Region: EamA; cl17759 243231002511 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 243231002512 conserved nucleotide sequence; similar to other Geobacter species; GSUR0127 243231002513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231002514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231002515 conserved nucleotide sequence; similar to other Geobacter species; GSUR0128 243231002516 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 243231002517 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 243231002518 NADP binding site [chemical binding]; other site 243231002519 dimer interface [polypeptide binding]; other site 243231002520 conserved nucleotide sequence; similar to other Geobacter species; GSUR0129 243231002521 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 243231002522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231002523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243231002524 putative substrate translocation pore; other site 243231002525 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 243231002526 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 243231002527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231002528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002529 dimerization interface [polypeptide binding]; other site 243231002530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002531 dimer interface [polypeptide binding]; other site 243231002532 phosphorylation site [posttranslational modification] 243231002533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002534 ATP binding site [chemical binding]; other site 243231002535 Mg2+ binding site [ion binding]; other site 243231002536 G-X-G motif; other site 243231002537 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231002538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002539 active site 243231002540 phosphorylation site [posttranslational modification] 243231002541 intermolecular recognition site; other site 243231002542 dimerization interface [polypeptide binding]; other site 243231002543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002544 Walker A motif; other site 243231002545 ATP binding site [chemical binding]; other site 243231002546 Walker B motif; other site 243231002547 arginine finger; other site 243231002548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231002549 conserved nucleotide sequence; similar to other Geobacter species; GSUR0130 243231002550 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 243231002551 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 243231002552 [4Fe-4S] binding site [ion binding]; other site 243231002553 molybdopterin cofactor binding site; other site 243231002554 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 243231002555 molybdopterin cofactor binding site; other site 243231002556 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 243231002557 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243231002558 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 243231002559 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 243231002560 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243231002561 GTP binding site; other site 243231002562 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 243231002563 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 243231002564 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243231002565 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 243231002566 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 243231002567 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243231002568 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 243231002569 hydrogenase 2 large subunit; Provisional; Region: PRK10467 243231002570 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 243231002571 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 243231002572 putative substrate-binding site; other site 243231002573 nickel binding site [ion binding]; other site 243231002574 twin arginine translocase protein A; Provisional; Region: tatA; PRK14860 243231002575 palindrome; GSUR0131 243231002576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002577 active site 243231002578 phosphorylation site [posttranslational modification] 243231002579 intermolecular recognition site; other site 243231002580 dimerization interface [polypeptide binding]; other site 243231002581 Protein of unknown function (DUF2860); Region: DUF2860; pfam11059 243231002582 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 243231002583 NRDE protein; Region: NRDE; pfam05742 243231002584 NosL; Region: NosL; cl01769 243231002585 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 243231002586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231002587 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243231002588 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231002589 active site residue [active] 243231002590 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231002591 active site residue [active] 243231002592 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 243231002593 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 243231002594 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243231002595 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243231002596 Walker A/P-loop; other site 243231002597 ATP binding site [chemical binding]; other site 243231002598 Q-loop/lid; other site 243231002599 ABC transporter signature motif; other site 243231002600 Walker B; other site 243231002601 D-loop; other site 243231002602 H-loop/switch region; other site 243231002603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231002604 binding surface 243231002605 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243231002606 TPR motif; other site 243231002607 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 243231002608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231002609 dimer interface [polypeptide binding]; other site 243231002610 conserved gate region; other site 243231002611 putative PBP binding loops; other site 243231002612 ABC-ATPase subunit interface; other site 243231002613 conserved nucleotide sequence; similar to other Geobacter species; GSUR1002 243231002614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231002615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231002616 substrate binding pocket [chemical binding]; other site 243231002617 membrane-bound complex binding site; other site 243231002618 hinge residues; other site 243231002619 Alginate export; Region: Alginate_exp; pfam13372 243231002620 classical (c) SDRs; Region: SDR_c; cd05233 243231002621 short chain dehydrogenase; Provisional; Region: PRK07041 243231002622 NAD(P) binding site [chemical binding]; other site 243231002623 active site 243231002624 phosphoenolpyruvate synthase; Validated; Region: PRK06464 243231002625 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 243231002626 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243231002627 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243231002628 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 243231002629 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 243231002630 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 243231002631 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 243231002632 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243231002633 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243231002634 ligand binding site [chemical binding]; other site 243231002635 flexible hinge region; other site 243231002636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231002637 metal binding site [ion binding]; metal-binding site 243231002638 active site 243231002639 I-site; other site 243231002640 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 243231002641 active site clefts [active] 243231002642 zinc binding site [ion binding]; other site 243231002643 dimer interface [polypeptide binding]; other site 243231002644 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 243231002645 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231002646 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231002647 ligand binding site [chemical binding]; other site 243231002648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231002649 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231002650 ligand binding site [chemical binding]; other site 243231002651 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231002652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002653 active site 243231002654 phosphorylation site [posttranslational modification] 243231002655 intermolecular recognition site; other site 243231002656 dimerization interface [polypeptide binding]; other site 243231002657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002658 Walker A motif; other site 243231002659 ATP binding site [chemical binding]; other site 243231002660 Walker B motif; other site 243231002661 arginine finger; other site 243231002662 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243231002663 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 243231002664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002665 dimerization interface [polypeptide binding]; other site 243231002666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002667 putative active site [active] 243231002668 heme pocket [chemical binding]; other site 243231002669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002670 dimer interface [polypeptide binding]; other site 243231002671 phosphorylation site [posttranslational modification] 243231002672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002673 ATP binding site [chemical binding]; other site 243231002674 Mg2+ binding site [ion binding]; other site 243231002675 G-X-G motif; other site 243231002676 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 243231002677 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243231002678 Outer membrane efflux protein; Region: OEP; pfam02321 243231002679 Outer membrane efflux protein; Region: OEP; pfam02321 243231002680 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243231002681 mce related protein; Region: MCE; pfam02470 243231002682 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 243231002683 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243231002684 Walker A/P-loop; other site 243231002685 ATP binding site [chemical binding]; other site 243231002686 Q-loop/lid; other site 243231002687 ABC transporter signature motif; other site 243231002688 Walker B; other site 243231002689 D-loop; other site 243231002690 H-loop/switch region; other site 243231002691 Permease; Region: Permease; pfam02405 243231002692 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 243231002693 tetrameric interface [polypeptide binding]; other site 243231002694 activator binding site; other site 243231002695 NADP binding site [chemical binding]; other site 243231002696 substrate binding site [chemical binding]; other site 243231002697 catalytic residues [active] 243231002698 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243231002699 NADPH bind site [chemical binding]; other site 243231002700 putative FMN binding site [chemical binding]; other site 243231002701 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 243231002702 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243231002703 tandem repeat interface [polypeptide binding]; other site 243231002704 oligomer interface [polypeptide binding]; other site 243231002705 active site residues [active] 243231002706 Cache domain; Region: Cache_1; pfam02743 243231002707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 243231002708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002709 dimerization interface [polypeptide binding]; other site 243231002710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002711 putative active site [active] 243231002712 heme pocket [chemical binding]; other site 243231002713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002714 dimer interface [polypeptide binding]; other site 243231002715 phosphorylation site [posttranslational modification] 243231002716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002717 ATP binding site [chemical binding]; other site 243231002718 Mg2+ binding site [ion binding]; other site 243231002719 G-X-G motif; other site 243231002720 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 243231002721 SseB protein N-terminal domain; Region: SseB; pfam07179 243231002722 Pirin-related protein [General function prediction only]; Region: COG1741 243231002723 Pirin; Region: Pirin; pfam02678 243231002724 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 243231002725 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243231002726 Outer membrane efflux protein; Region: OEP; pfam02321 243231002727 Outer membrane efflux protein; Region: OEP; pfam02321 243231002728 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231002729 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243231002730 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231002731 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243231002732 MMPL family; Region: MMPL; cl14618 243231002733 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243231002734 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 243231002735 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 243231002736 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 243231002737 Rnk N-terminus; Region: Rnk_N; pfam14760 243231002738 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243231002739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002740 active site 243231002741 phosphorylation site [posttranslational modification] 243231002742 intermolecular recognition site; other site 243231002743 dimerization interface [polypeptide binding]; other site 243231002744 conserved nucleotide sequence; similar to other Geobacter species; GSUR0132 243231002745 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231002746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002747 active site 243231002748 phosphorylation site [posttranslational modification] 243231002749 intermolecular recognition site; other site 243231002750 dimerization interface [polypeptide binding]; other site 243231002751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231002752 Walker A motif; other site 243231002753 ATP binding site [chemical binding]; other site 243231002754 Walker B motif; other site 243231002755 arginine finger; other site 243231002756 GAF domain; Region: GAF_2; pfam13185 243231002757 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231002758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231002759 putative active site [active] 243231002760 heme pocket [chemical binding]; other site 243231002761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002762 dimer interface [polypeptide binding]; other site 243231002763 phosphorylation site [posttranslational modification] 243231002764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002765 ATP binding site [chemical binding]; other site 243231002766 Mg2+ binding site [ion binding]; other site 243231002767 G-X-G motif; other site 243231002768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002769 active site 243231002770 phosphorylation site [posttranslational modification] 243231002771 intermolecular recognition site; other site 243231002772 dimerization interface [polypeptide binding]; other site 243231002773 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 243231002774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231002775 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243231002776 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 243231002777 transmembrane helices; other site 243231002778 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 243231002779 TrkA-C domain; Region: TrkA_C; pfam02080 243231002780 TrkA-C domain; Region: TrkA_C; pfam02080 243231002781 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 243231002782 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 243231002783 iron-sulfur cluster [ion binding]; other site 243231002784 [2Fe-2S] cluster binding site [ion binding]; other site 243231002785 aconitate hydratase; Validated; Region: PRK09277 243231002786 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 243231002787 substrate binding site [chemical binding]; other site 243231002788 ligand binding site [chemical binding]; other site 243231002789 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 243231002790 substrate binding site [chemical binding]; other site 243231002791 Rubredoxin [Energy production and conversion]; Region: COG1773 243231002792 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243231002793 iron binding site [ion binding]; other site 243231002794 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243231002795 conserved nucleotide sequence; similar to other Geobacter species; GSUR0133 243231002796 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 243231002797 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 243231002798 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 243231002799 Fe binding site [ion binding]; other site 243231002800 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 243231002801 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 243231002802 dimerization domain [polypeptide binding]; other site 243231002803 dimer interface [polypeptide binding]; other site 243231002804 catalytic residues [active] 243231002805 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 243231002806 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243231002807 Domain of unknown function DUF21; Region: DUF21; pfam01595 243231002808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243231002809 Transporter associated domain; Region: CorC_HlyC; smart01091 243231002810 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243231002811 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 243231002812 Peptidase family M48; Region: Peptidase_M48; cl12018 243231002813 conserved nucleotide sequence; similar to other Geobacter species; GSUR0066 243231002814 Predicted membrane protein [Function unknown]; Region: COG2119 243231002815 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 243231002816 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 243231002817 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243231002818 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 243231002819 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 243231002820 active site 243231002821 tetramer interface; other site 243231002822 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 243231002823 FAD binding site [chemical binding]; other site 243231002824 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 243231002825 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 243231002826 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243231002827 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243231002828 homodimer interface [polypeptide binding]; other site 243231002829 NADP binding site [chemical binding]; other site 243231002830 substrate binding site [chemical binding]; other site 243231002831 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 243231002832 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 243231002833 DivIVA protein; Region: DivIVA; pfam05103 243231002834 YGGT family; Region: YGGT; pfam02325 243231002835 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 243231002836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002837 S-adenosylmethionine binding site [chemical binding]; other site 243231002838 Uncharacterized conserved protein [Function unknown]; Region: COG1624 243231002839 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 243231002840 YbbR-like protein; Region: YbbR; pfam07949 243231002841 YbbR-like protein; Region: YbbR; pfam07949 243231002842 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231002843 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 243231002844 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231002845 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243231002846 NlpC/P60 family; Region: NLPC_P60; pfam00877 243231002847 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 243231002848 active site 243231002849 8-oxo-dGMP binding site [chemical binding]; other site 243231002850 nudix motif; other site 243231002851 metal binding site [ion binding]; metal-binding site 243231002852 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231002853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231002854 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231002855 FeS/SAM binding site; other site 243231002856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231002857 TPR motif; other site 243231002858 TPR repeat; Region: TPR_11; pfam13414 243231002859 binding surface 243231002860 heat shock 70 kDa protein; Provisional; Region: PTZ00009 243231002861 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 243231002862 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243231002863 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 243231002864 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 243231002865 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 243231002866 conserved nucleotide sequence; similar to other Geobacter species; GSUR0134 243231002867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002868 active site 243231002869 phosphorylation site [posttranslational modification] 243231002870 intermolecular recognition site; other site 243231002871 dimerization interface [polypeptide binding]; other site 243231002872 PilZ domain; Region: PilZ; pfam07238 243231002873 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 243231002874 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 243231002875 Probable Catalytic site; other site 243231002876 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 243231002877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231002878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002879 active site 243231002880 phosphorylation site [posttranslational modification] 243231002881 intermolecular recognition site; other site 243231002882 dimerization interface [polypeptide binding]; other site 243231002883 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 243231002884 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 243231002885 putative [4Fe-4S] binding site [ion binding]; other site 243231002886 putative molybdopterin cofactor binding site [chemical binding]; other site 243231002887 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 243231002888 putative molybdopterin cofactor binding site; other site 243231002889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231002890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231002891 dimerization interface [polypeptide binding]; other site 243231002892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002893 dimer interface [polypeptide binding]; other site 243231002894 phosphorylation site [posttranslational modification] 243231002895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002896 ATP binding site [chemical binding]; other site 243231002897 Mg2+ binding site [ion binding]; other site 243231002898 G-X-G motif; other site 243231002899 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243231002900 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 243231002901 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243231002902 putative radical SAM-modified peptide; Region: geopeptide; TIGR04229 243231002903 palindrome; GSUR0135 243231002904 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 243231002905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231002906 FeS/SAM binding site; other site 243231002907 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243231002908 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231002909 AAA domain; Region: AAA_26; pfam13500 243231002910 DRTGG domain; Region: DRTGG; pfam07085 243231002911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231002912 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231002913 FeS/SAM binding site; other site 243231002914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 243231002915 AAA domain; Region: AAA_33; pfam13671 243231002916 acylphosphatase; Provisional; Region: PRK14438 243231002917 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 243231002918 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243231002919 nucleotide binding pocket [chemical binding]; other site 243231002920 K-X-D-G motif; other site 243231002921 catalytic site [active] 243231002922 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243231002923 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243231002924 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243231002925 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 243231002926 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243231002927 Dimer interface [polypeptide binding]; other site 243231002928 BRCT sequence motif; other site 243231002929 CHAD domain; Region: CHAD; cl10506 243231002930 Subtilase family; Region: Peptidase_S8; pfam00082 243231002931 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243231002932 active site 243231002933 catalytic residues [active] 243231002934 Domain of unknown function DUF11; Region: DUF11; pfam01345 243231002935 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 243231002936 Part of AAA domain; Region: AAA_19; pfam13245 243231002937 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243231002938 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243231002939 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243231002940 dimer interface [polypeptide binding]; other site 243231002941 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243231002942 catalytic triad [active] 243231002943 peroxidatic and resolving cysteines [active] 243231002944 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 243231002945 substrate binding site [chemical binding]; other site 243231002946 Sensory domain found in PocR; Region: PocR; cl19879 243231002947 GAF domain; Region: GAF_2; pfam13185 243231002948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231002949 metal binding site [ion binding]; metal-binding site 243231002950 active site 243231002951 I-site; other site 243231002952 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243231002953 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 243231002954 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 243231002955 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 243231002956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231002957 ATP binding site [chemical binding]; other site 243231002958 putative Mg++ binding site [ion binding]; other site 243231002959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231002960 nucleotide binding region [chemical binding]; other site 243231002961 ATP-binding site [chemical binding]; other site 243231002962 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 243231002963 HRDC domain; Region: HRDC; pfam00570 243231002964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 243231002965 Protein of unknown function (DUF445); Region: DUF445; pfam04286 243231002966 Trm112p-like protein; Region: Trm112p; pfam03966 243231002967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231002968 S-adenosylmethionine binding site [chemical binding]; other site 243231002969 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 243231002970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231002971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002972 active site 243231002973 phosphorylation site [posttranslational modification] 243231002974 intermolecular recognition site; other site 243231002975 dimerization interface [polypeptide binding]; other site 243231002976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231002977 active site 243231002978 phosphorylation site [posttranslational modification] 243231002979 intermolecular recognition site; other site 243231002980 dimerization interface [polypeptide binding]; other site 243231002981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231002982 dimer interface [polypeptide binding]; other site 243231002983 phosphorylation site [posttranslational modification] 243231002984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231002985 ATP binding site [chemical binding]; other site 243231002986 Mg2+ binding site [ion binding]; other site 243231002987 G-X-G motif; other site 243231002988 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231002989 Zn2+ binding site [ion binding]; other site 243231002990 Mg2+ binding site [ion binding]; other site 243231002991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243231002992 DNA-binding site [nucleotide binding]; DNA binding site 243231002993 RNA-binding motif; other site 243231002994 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243231002995 hypothetical protein; Provisional; Region: PRK08328 243231002996 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243231002997 ATP binding site [chemical binding]; other site 243231002998 substrate interface [chemical binding]; other site 243231002999 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 243231003000 MoaE interaction surface [polypeptide binding]; other site 243231003001 MoeB interaction surface [polypeptide binding]; other site 243231003002 thiocarboxylated glycine; other site 243231003003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 243231003004 mercuric reductase; Validated; Region: PRK06370 243231003005 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 243231003006 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 243231003007 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 243231003008 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 243231003009 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231003010 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231003011 ABC transporter ATPase component; Reviewed; Region: PRK11147 243231003012 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231003013 ABC transporter; Region: ABC_tran_2; pfam12848 243231003014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231003015 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 243231003016 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243231003017 ATP binding site [chemical binding]; other site 243231003018 Mg++ binding site [ion binding]; other site 243231003019 motif III; other site 243231003020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231003021 nucleotide binding region [chemical binding]; other site 243231003022 ATP-binding site [chemical binding]; other site 243231003023 HAMP domain; Region: HAMP; pfam00672 243231003024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003026 dimer interface [polypeptide binding]; other site 243231003027 putative CheW interface [polypeptide binding]; other site 243231003028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 243231003029 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 243231003030 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 243231003031 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243231003032 homodimer interface [polypeptide binding]; other site 243231003033 oligonucleotide binding site [chemical binding]; other site 243231003034 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 243231003035 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243231003036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231003037 ABC transporter; Region: ABC_tran_2; pfam12848 243231003038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231003039 ABC transporter; Region: ABC_tran_2; pfam12848 243231003040 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 243231003041 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243231003042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003043 Walker A motif; other site 243231003044 ATP binding site [chemical binding]; other site 243231003045 Walker B motif; other site 243231003046 arginine finger; other site 243231003047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243231003048 Permease; Region: Permease; pfam02405 243231003049 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243231003050 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243231003051 Walker A/P-loop; other site 243231003052 ATP binding site [chemical binding]; other site 243231003053 Q-loop/lid; other site 243231003054 ABC transporter signature motif; other site 243231003055 Walker B; other site 243231003056 D-loop; other site 243231003057 H-loop/switch region; other site 243231003058 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243231003059 mce related protein; Region: MCE; pfam02470 243231003060 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243231003061 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243231003062 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243231003063 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243231003064 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243231003065 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243231003066 palindrome; GSUR0136 243231003067 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231003068 active site residue [active] 243231003069 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231003070 active site residue [active] 243231003071 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231003072 active site residue [active] 243231003073 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231003074 active site residue [active] 243231003075 YceI-like domain; Region: YceI; pfam04264 243231003076 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 243231003077 Sulfate transporter family; Region: Sulfate_transp; cl19250 243231003078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231003079 active site 243231003080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003081 dimerization interface [polypeptide binding]; other site 243231003082 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003083 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003084 dimer interface [polypeptide binding]; other site 243231003085 putative CheW interface [polypeptide binding]; other site 243231003086 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 243231003087 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 243231003088 catalytic triad [active] 243231003089 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 243231003090 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 243231003091 active site 243231003092 catalytic residues [active] 243231003093 metal binding site [ion binding]; metal-binding site 243231003094 Nitrogen regulatory protein P-II; Region: P-II; smart00938 243231003095 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243231003096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003097 dimer interface [polypeptide binding]; other site 243231003098 phosphorylation site [posttranslational modification] 243231003099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003100 ATP binding site [chemical binding]; other site 243231003101 Mg2+ binding site [ion binding]; other site 243231003102 G-X-G motif; other site 243231003103 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 243231003104 active site 243231003105 dimerization interface [polypeptide binding]; other site 243231003106 PilZ domain; Region: PilZ; pfam07238 243231003107 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243231003108 homodimer interface [polypeptide binding]; other site 243231003109 substrate-cofactor binding pocket; other site 243231003110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231003111 catalytic residue [active] 243231003112 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243231003113 homodimer interface [polypeptide binding]; other site 243231003114 substrate-cofactor binding pocket; other site 243231003115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231003116 catalytic residue [active] 243231003117 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231003118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003119 dimerization interface [polypeptide binding]; other site 243231003120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003121 PAS domain; Region: PAS_9; pfam13426 243231003122 putative active site [active] 243231003123 heme pocket [chemical binding]; other site 243231003124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231003125 metal binding site [ion binding]; metal-binding site 243231003126 active site 243231003127 I-site; other site 243231003128 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231003129 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231003130 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231003131 Walker A/P-loop; other site 243231003132 ATP binding site [chemical binding]; other site 243231003133 Q-loop/lid; other site 243231003134 ABC transporter signature motif; other site 243231003135 Walker B; other site 243231003136 D-loop; other site 243231003137 H-loop/switch region; other site 243231003138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231003139 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243231003140 FtsX-like permease family; Region: FtsX; pfam02687 243231003141 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243231003142 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231003143 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231003144 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 243231003145 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243231003146 Outer membrane efflux protein; Region: OEP; pfam02321 243231003147 Outer membrane efflux protein; Region: OEP; pfam02321 243231003148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231003149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231003150 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 243231003151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231003152 metal binding site [ion binding]; metal-binding site 243231003153 active site 243231003154 I-site; other site 243231003155 conserved nucleotide sequence; similar to other Geobacter species; GSUR0137 243231003156 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243231003157 palindrome; GSUR0138 243231003158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 243231003159 Bacterial dnaA protein helix-turn-helix domain; Region: Bac_DnaA_C; smart00760 243231003160 DnaA box-binding interface [nucleotide binding]; other site 243231003161 conserved nucleotide sequence; similar to other Geobacter species; GSUR0139 243231003162 conserved nucleotide sequence; similar to other Geobacter species; GSUR0140 243231003163 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 243231003164 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 243231003165 putative active site [active] 243231003166 putative NTP binding site [chemical binding]; other site 243231003167 putative nucleic acid binding site [nucleotide binding]; other site 243231003168 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 243231003169 conserved nucleotide sequence; similar to other Geobacter species; GSUR0141 243231003170 conserved nucleotide sequence; similar to other Geobacter species; GSUR0142 243231003171 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 243231003172 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231003173 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243231003174 conserved nucleotide sequence; similar to other Geobacter species; GSUR0143 243231003175 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243231003176 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243231003177 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243231003178 conserved nucleotide sequence; similar to other Geobacter species; GSUR0144 243231003179 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243231003180 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243231003181 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231003182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003183 dimerization interface [polypeptide binding]; other site 243231003184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003185 dimer interface [polypeptide binding]; other site 243231003186 phosphorylation site [posttranslational modification] 243231003187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003188 ATP binding site [chemical binding]; other site 243231003189 Mg2+ binding site [ion binding]; other site 243231003190 G-X-G motif; other site 243231003191 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231003192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003193 active site 243231003194 phosphorylation site [posttranslational modification] 243231003195 intermolecular recognition site; other site 243231003196 dimerization interface [polypeptide binding]; other site 243231003197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003198 Walker A motif; other site 243231003199 ATP binding site [chemical binding]; other site 243231003200 Walker B motif; other site 243231003201 arginine finger; other site 243231003202 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243231003203 conserved nucleotide sequence; similar to other Geobacter species; GSUR0145 243231003204 conserved nucleotide sequence; similar to other Geobacter species; GSUR0146 243231003205 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243231003206 C-terminal peptidase (prc); Region: prc; TIGR00225 243231003207 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243231003208 protein binding site [polypeptide binding]; other site 243231003209 Catalytic dyad [active] 243231003210 palindrome; GSUR0147 243231003211 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 243231003212 RF-1 domain; Region: RF-1; pfam00472 243231003213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231003214 ABC transporter signature motif; other site 243231003215 Walker B; other site 243231003216 D-loop; other site 243231003217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003218 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243231003219 Walker A motif; other site 243231003220 ATP binding site [chemical binding]; other site 243231003221 Walker B motif; other site 243231003222 arginine finger; other site 243231003223 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 243231003224 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243231003225 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 243231003226 conserved hypothetical phage tail region protein; Region: TIGR02241 243231003227 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 243231003228 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231003229 Phage protein D [General function prediction only]; Region: COG3500 243231003230 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243231003231 conserved nucleotide sequence; similar to other Geobacter species; GSUR7002 243231003232 PAAR motif; Region: PAAR_motif; cl15808 243231003233 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 243231003234 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 243231003235 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 243231003236 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 243231003237 NHL repeat; Region: NHL; pfam01436 243231003238 phage tail protein domain; Region: tail_TIGR02242 243231003239 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243231003240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231003241 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 243231003242 putative ADP-binding pocket [chemical binding]; other site 243231003243 flagellar motor protein MotB; Validated; Region: motB; PRK05996 243231003244 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243231003245 CoenzymeA binding site [chemical binding]; other site 243231003246 subunit interaction site [polypeptide binding]; other site 243231003247 PHB binding site; other site 243231003248 fumarate hydratase; Provisional; Region: PRK15389 243231003249 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 243231003250 Fumarase C-terminus; Region: Fumerase_C; pfam05683 243231003251 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 243231003252 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 243231003253 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243231003254 DNA binding site [nucleotide binding] 243231003255 catalytic residue [active] 243231003256 H2TH interface [polypeptide binding]; other site 243231003257 putative catalytic residues [active] 243231003258 turnover-facilitating residue; other site 243231003259 intercalation triad [nucleotide binding]; other site 243231003260 8OG recognition residue [nucleotide binding]; other site 243231003261 putative reading head residues; other site 243231003262 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243231003263 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243231003264 replicative DNA helicase; Region: DnaB; TIGR00665 243231003265 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 243231003266 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243231003267 Walker A motif; other site 243231003268 ATP binding site [chemical binding]; other site 243231003269 Walker B motif; other site 243231003270 DNA binding loops [nucleotide binding] 243231003271 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461 243231003272 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243231003273 active site 243231003274 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 243231003275 catalytic triad [active] 243231003276 dimer interface [polypeptide binding]; other site 243231003277 conserved cis-peptide bond; other site 243231003278 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231003279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003280 active site 243231003281 phosphorylation site [posttranslational modification] 243231003282 intermolecular recognition site; other site 243231003283 dimerization interface [polypeptide binding]; other site 243231003284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003285 Walker A motif; other site 243231003286 ATP binding site [chemical binding]; other site 243231003287 Walker B motif; other site 243231003288 arginine finger; other site 243231003289 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243231003290 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231003291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003292 putative active site [active] 243231003293 heme pocket [chemical binding]; other site 243231003294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003295 dimer interface [polypeptide binding]; other site 243231003296 phosphorylation site [posttranslational modification] 243231003297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003298 ATP binding site [chemical binding]; other site 243231003299 Mg2+ binding site [ion binding]; other site 243231003300 G-X-G motif; other site 243231003301 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 243231003302 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 243231003303 FMN binding site [chemical binding]; other site 243231003304 active site 243231003305 catalytic residues [active] 243231003306 substrate binding site [chemical binding]; other site 243231003307 GAF domain; Region: GAF_3; pfam13492 243231003308 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243231003309 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 243231003310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231003311 Zn2+ binding site [ion binding]; other site 243231003312 Mg2+ binding site [ion binding]; other site 243231003313 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 243231003314 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 243231003315 NAD binding site [chemical binding]; other site 243231003316 homotetramer interface [polypeptide binding]; other site 243231003317 homodimer interface [polypeptide binding]; other site 243231003318 substrate binding site [chemical binding]; other site 243231003319 active site 243231003320 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 243231003321 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 243231003322 HflX GTPase family; Region: HflX; cd01878 243231003323 G1 box; other site 243231003324 GTP/Mg2+ binding site [chemical binding]; other site 243231003325 Switch I region; other site 243231003326 G2 box; other site 243231003327 G3 box; other site 243231003328 Switch II region; other site 243231003329 G4 box; other site 243231003330 G5 box; other site 243231003331 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243231003332 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243231003333 catalytic residue [active] 243231003334 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231003335 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 243231003336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231003337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003338 binding surface 243231003339 TPR motif; other site 243231003340 Protein of unknown function (DUF401); Region: DUF401; cl00830 243231003341 Tht1-like nuclear fusion protein; Region: Tht1; pfam04163 243231003342 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231003343 ligand binding site [chemical binding]; other site 243231003344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 243231003345 Smr domain; Region: Smr; pfam01713 243231003346 Predicted permease [General function prediction only]; Region: COG2985 243231003347 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 243231003348 TrkA-C domain; Region: TrkA_C; pfam02080 243231003349 TrkA-C domain; Region: TrkA_C; pfam02080 243231003350 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 243231003351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231003352 active site 243231003353 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 243231003354 Sulfate transporter family; Region: Sulfate_transp; cl19250 243231003355 glycogen synthase; Provisional; Region: glgA; PRK00654 243231003356 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 243231003357 ADP-binding pocket [chemical binding]; other site 243231003358 homodimer interface [polypeptide binding]; other site 243231003359 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231003360 heme-binding residues [chemical binding]; other site 243231003361 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 243231003362 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 243231003363 putative active site; other site 243231003364 catalytic triad [active] 243231003365 putative dimer interface [polypeptide binding]; other site 243231003366 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 243231003367 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231003368 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231003369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003370 dimerization interface [polypeptide binding]; other site 243231003371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003372 dimer interface [polypeptide binding]; other site 243231003373 putative CheW interface [polypeptide binding]; other site 243231003374 conserved nucleotide sequence; similar to other Geobacter species; GSUR0148 243231003375 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243231003376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003377 dimerization interface [polypeptide binding]; other site 243231003378 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003380 dimer interface [polypeptide binding]; other site 243231003381 putative CheW interface [polypeptide binding]; other site 243231003382 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 243231003383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003384 dimerization interface [polypeptide binding]; other site 243231003385 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003387 dimer interface [polypeptide binding]; other site 243231003388 putative CheW interface [polypeptide binding]; other site 243231003389 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 243231003390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003391 dimerization interface [polypeptide binding]; other site 243231003392 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003393 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003394 dimer interface [polypeptide binding]; other site 243231003395 putative CheW interface [polypeptide binding]; other site 243231003396 Nitrate and nitrite sensing; Region: NIT; pfam08376 243231003397 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231003398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003399 dimerization interface [polypeptide binding]; other site 243231003400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003401 dimer interface [polypeptide binding]; other site 243231003402 putative CheW interface [polypeptide binding]; other site 243231003403 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003404 dimerization interface [polypeptide binding]; other site 243231003405 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003406 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003407 dimer interface [polypeptide binding]; other site 243231003408 putative CheW interface [polypeptide binding]; other site 243231003409 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 243231003410 SGF29 tudor-like domain; Region: DUF1325; pfam07039 243231003411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003412 dimer interface [polypeptide binding]; other site 243231003413 phosphorylation site [posttranslational modification] 243231003414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003415 ATP binding site [chemical binding]; other site 243231003416 Mg2+ binding site [ion binding]; other site 243231003417 G-X-G motif; other site 243231003418 response regulator PleD; Reviewed; Region: pleD; PRK09581 243231003419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003420 active site 243231003421 phosphorylation site [posttranslational modification] 243231003422 intermolecular recognition site; other site 243231003423 dimerization interface [polypeptide binding]; other site 243231003424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231003425 metal binding site [ion binding]; metal-binding site 243231003426 active site 243231003427 I-site; other site 243231003428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231003429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003430 active site 243231003431 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243231003432 phosphorylation site [posttranslational modification] 243231003433 intermolecular recognition site; other site 243231003434 dimerization interface [polypeptide binding]; other site 243231003435 PAS domain; Region: PAS; smart00091 243231003436 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231003437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003438 dimer interface [polypeptide binding]; other site 243231003439 phosphorylation site [posttranslational modification] 243231003440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003441 ATP binding site [chemical binding]; other site 243231003442 Mg2+ binding site [ion binding]; other site 243231003443 G-X-G motif; other site 243231003444 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231003445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003446 active site 243231003447 phosphorylation site [posttranslational modification] 243231003448 intermolecular recognition site; other site 243231003449 dimerization interface [polypeptide binding]; other site 243231003450 PAS domain; Region: PAS_9; pfam13426 243231003451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003452 putative active site [active] 243231003453 heme pocket [chemical binding]; other site 243231003454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003455 Walker A motif; other site 243231003456 ATP binding site [chemical binding]; other site 243231003457 Walker B motif; other site 243231003458 arginine finger; other site 243231003459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231003460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003461 dimerization interface [polypeptide binding]; other site 243231003462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231003464 dimer interface [polypeptide binding]; other site 243231003465 putative CheW interface [polypeptide binding]; other site 243231003466 Hemerythrin; Region: Hemerythrin; cd12107 243231003467 Fe binding site [ion binding]; other site 243231003468 PAS fold; Region: PAS_4; pfam08448 243231003469 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003470 putative active site [active] 243231003471 heme pocket [chemical binding]; other site 243231003472 PAS domain S-box; Region: sensory_box; TIGR00229 243231003473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003474 putative active site [active] 243231003475 heme pocket [chemical binding]; other site 243231003476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231003477 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 243231003478 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003479 dimer interface [polypeptide binding]; other site 243231003480 phosphorylation site [posttranslational modification] 243231003481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003482 ATP binding site [chemical binding]; other site 243231003483 Mg2+ binding site [ion binding]; other site 243231003484 G-X-G motif; other site 243231003485 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 243231003486 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 243231003487 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 243231003488 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 243231003489 putative NADH binding site [chemical binding]; other site 243231003490 putative active site [active] 243231003491 nudix motif; other site 243231003492 putative metal binding site [ion binding]; other site 243231003493 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 243231003494 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 243231003495 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243231003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231003497 S-adenosylmethionine binding site [chemical binding]; other site 243231003498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 243231003499 SEC-C motif; Region: SEC-C; cl19389 243231003500 SEC-C motif; Region: SEC-C; cl19389 243231003501 ribonuclease Z; Provisional; Region: PRK02126 243231003502 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231003503 PAS domain; Region: PAS_8; pfam13188 243231003504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003505 dimer interface [polypeptide binding]; other site 243231003506 phosphorylation site [posttranslational modification] 243231003507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003508 ATP binding site [chemical binding]; other site 243231003509 Mg2+ binding site [ion binding]; other site 243231003510 G-X-G motif; other site 243231003511 conserved nucleotide sequence; similar to other Geobacter species; GSUR0149 243231003512 PilZ domain; Region: PilZ; cl01260 243231003513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231003514 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243231003515 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 243231003516 nucleophilic elbow; other site 243231003517 catalytic triad; other site 243231003518 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243231003519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003520 putative active site [active] 243231003521 heme pocket [chemical binding]; other site 243231003522 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243231003523 CPxP motif; other site 243231003524 Sulphur transport; Region: Sulf_transp; cl19477 243231003525 Sulphur transport; Region: Sulf_transp; cl19477 243231003526 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 243231003527 TPR repeat; Region: TPR_11; pfam13414 243231003528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003529 binding surface 243231003530 TPR motif; other site 243231003531 TPR repeat; Region: TPR_11; pfam13414 243231003532 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 243231003533 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 243231003534 CoA-ligase; Region: Ligase_CoA; pfam00549 243231003535 conserved nucleotide sequence; similar to other Geobacter species; GSUR0297 243231003536 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 243231003537 CoA binding domain; Region: CoA_binding; smart00881 243231003538 CoA-ligase; Region: Ligase_CoA; pfam00549 243231003539 aspartate aminotransferase; Provisional; Region: PRK06836 243231003540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231003541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231003542 homodimer interface [polypeptide binding]; other site 243231003543 catalytic residue [active] 243231003544 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 243231003545 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 243231003546 Type II secretion system (T2SS), protein J; Region: T2SJ; cl19722 243231003547 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 243231003548 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243231003549 metal binding triad; other site 243231003550 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 243231003551 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243231003552 Na binding site [ion binding]; other site 243231003553 Protein of unknown function, DUF485; Region: DUF485; pfam04341 243231003554 conserved palindrome; GSUR0150 243231003555 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243231003556 Na binding site [ion binding]; other site 243231003557 Protein of unknown function, DUF485; Region: DUF485; pfam04341 243231003558 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 243231003559 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243231003560 Bacterial transcriptional regulator; Region: IclR; pfam01614 243231003561 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 243231003562 hypothetical protein; Validated; Region: PRK00110 243231003563 conserved nucleotide sequence; similar to other Geobacter species; GSUR6001 243231003564 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 243231003565 active site 243231003566 putative DNA-binding cleft [nucleotide binding]; other site 243231003567 dimer interface [polypeptide binding]; other site 243231003568 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 243231003569 RuvA N terminal domain; Region: RuvA_N; pfam01330 243231003570 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243231003571 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 243231003572 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 243231003573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003574 Walker A motif; other site 243231003575 ATP binding site [chemical binding]; other site 243231003576 Walker B motif; other site 243231003577 arginine finger; other site 243231003578 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243231003579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003580 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243231003581 Walker A motif; other site 243231003582 ATP binding site [chemical binding]; other site 243231003583 Walker B motif; other site 243231003584 arginine finger; other site 243231003585 PEP-CTERM motif; Region: VPEP; pfam07589 243231003586 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 243231003587 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 243231003588 Ligand Binding Site [chemical binding]; other site 243231003589 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 243231003590 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 243231003591 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 243231003592 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 243231003593 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 243231003594 Predicted DNA-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG1571 243231003595 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 243231003596 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 243231003597 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 243231003598 active site 243231003599 ATP binding site [chemical binding]; other site 243231003600 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 243231003601 Domain of unknown function (DUF362); Region: DUF362; cl19822 243231003602 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231003603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003604 active site 243231003605 phosphorylation site [posttranslational modification] 243231003606 intermolecular recognition site; other site 243231003607 dimerization interface [polypeptide binding]; other site 243231003608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 243231003609 Tim44-like domain; Region: Tim44; pfam04280 243231003610 GH3 auxin-responsive promoter; Region: GH3; pfam03321 243231003611 indole-3-acetic acid-amido synthetase; Region: PLN02249 243231003612 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 243231003613 PhoU domain; Region: PhoU; pfam01895 243231003614 PhoU domain; Region: PhoU; pfam01895 243231003615 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14252 243231003616 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243231003617 Walker A/P-loop; other site 243231003618 ATP binding site [chemical binding]; other site 243231003619 Q-loop/lid; other site 243231003620 ABC transporter signature motif; other site 243231003621 Walker B; other site 243231003622 D-loop; other site 243231003623 H-loop/switch region; other site 243231003624 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 243231003625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231003626 dimer interface [polypeptide binding]; other site 243231003627 conserved gate region; other site 243231003628 putative PBP binding loops; other site 243231003629 ABC-ATPase subunit interface; other site 243231003630 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 243231003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231003632 dimer interface [polypeptide binding]; other site 243231003633 conserved gate region; other site 243231003634 putative PBP binding loops; other site 243231003635 ABC-ATPase subunit interface; other site 243231003636 phosphate binding protein; Region: ptsS_2; TIGR02136 243231003637 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 243231003638 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003639 dimerization interface [polypeptide binding]; other site 243231003640 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231003641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231003642 putative active site [active] 243231003643 heme pocket [chemical binding]; other site 243231003644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003645 dimer interface [polypeptide binding]; other site 243231003646 phosphorylation site [posttranslational modification] 243231003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003648 ATP binding site [chemical binding]; other site 243231003649 Mg2+ binding site [ion binding]; other site 243231003650 G-X-G motif; other site 243231003651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231003652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003653 active site 243231003654 phosphorylation site [posttranslational modification] 243231003655 intermolecular recognition site; other site 243231003656 dimerization interface [polypeptide binding]; other site 243231003657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231003658 DNA binding site [nucleotide binding] 243231003659 conserved nucleotide sequence; similar to other Geobacter species; GSUR0151 243231003660 AMP-binding domain protein; Validated; Region: PRK08315 243231003661 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 243231003662 acyl-activating enzyme (AAE) consensus motif; other site 243231003663 putative AMP binding site [chemical binding]; other site 243231003664 putative active site [active] 243231003665 putative CoA binding site [chemical binding]; other site 243231003666 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243231003667 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243231003668 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 243231003669 active site 243231003670 conserved nucleotide sequence; similar to other Geobacter species; GSUR0152 243231003671 conserved nucleotide sequence; similar to other Geobacter species; GSUR0153 243231003672 Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103 243231003673 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 243231003674 dimer interface [polypeptide binding]; other site 243231003675 active site 243231003676 coenzyme A binding site [chemical binding]; other site 243231003677 citrylCoA binding site [chemical binding]; other site 243231003678 oxalacetate/citrate binding site [chemical binding]; other site 243231003679 catalytic triad [active] 243231003680 AMMECR1; Region: AMMECR1; pfam01871 243231003681 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 243231003682 NAD(P) binding site [chemical binding]; other site 243231003683 catalytic residues [active] 243231003684 Nucleoside diphosphate kinase; Region: NDK; pfam00334 243231003685 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 243231003686 active site 243231003687 multimer interface [polypeptide binding]; other site 243231003688 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 243231003689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231003690 FeS/SAM binding site; other site 243231003691 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 243231003692 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 243231003693 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 243231003694 substrate binding site [chemical binding]; other site 243231003695 ATP binding site [chemical binding]; other site 243231003696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003697 TPR repeat; Region: TPR_11; pfam13414 243231003698 binding surface 243231003699 TPR motif; other site 243231003700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003701 binding surface 243231003702 TPR motif; other site 243231003703 TPR repeat; Region: TPR_11; pfam13414 243231003704 TPR repeat; Region: TPR_11; pfam13414 243231003705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003706 binding surface 243231003707 TPR motif; other site 243231003708 TPR repeat; Region: TPR_11; pfam13414 243231003709 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 243231003710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231003711 non-specific DNA binding site [nucleotide binding]; other site 243231003712 salt bridge; other site 243231003713 sequence-specific DNA binding site [nucleotide binding]; other site 243231003714 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 243231003715 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 243231003716 GAF domain; Region: GAF; pfam01590 243231003717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003718 active site 243231003719 phosphorylation site [posttranslational modification] 243231003720 intermolecular recognition site; other site 243231003721 dimerization interface [polypeptide binding]; other site 243231003722 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243231003723 Ligand Binding Site [chemical binding]; other site 243231003724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003725 active site 243231003726 phosphorylation site [posttranslational modification] 243231003727 intermolecular recognition site; other site 243231003728 dimerization interface [polypeptide binding]; other site 243231003729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003730 dimer interface [polypeptide binding]; other site 243231003731 phosphorylation site [posttranslational modification] 243231003732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003733 ATP binding site [chemical binding]; other site 243231003734 Mg2+ binding site [ion binding]; other site 243231003735 G-X-G motif; other site 243231003736 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231003737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003738 active site 243231003739 phosphorylation site [posttranslational modification] 243231003740 intermolecular recognition site; other site 243231003741 dimerization interface [polypeptide binding]; other site 243231003742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231003743 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 243231003744 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 243231003745 generic binding surface II; other site 243231003746 generic binding surface I; other site 243231003747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231003748 Zn2+ binding site [ion binding]; other site 243231003749 Mg2+ binding site [ion binding]; other site 243231003750 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 243231003751 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 243231003752 Flavoprotein; Region: Flavoprotein; cl19190 243231003753 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 243231003754 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 243231003755 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 243231003756 Fe-S cluster binding site [ion binding]; other site 243231003757 active site 243231003758 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 243231003759 CoenzymeA binding site [chemical binding]; other site 243231003760 subunit interaction site [polypeptide binding]; other site 243231003761 PHB binding site; other site 243231003762 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231003763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003764 active site 243231003765 phosphorylation site [posttranslational modification] 243231003766 intermolecular recognition site; other site 243231003767 dimerization interface [polypeptide binding]; other site 243231003768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003769 Walker A motif; other site 243231003770 ATP binding site [chemical binding]; other site 243231003771 Walker B motif; other site 243231003772 arginine finger; other site 243231003773 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231003774 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243231003775 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243231003776 Walker A/P-loop; other site 243231003777 ATP binding site [chemical binding]; other site 243231003778 Q-loop/lid; other site 243231003779 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 243231003780 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; cl19842 243231003781 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243231003782 ABC transporter signature motif; other site 243231003783 Walker B; other site 243231003784 D-loop; other site 243231003785 H-loop/switch region; other site 243231003786 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 243231003787 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 243231003788 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 243231003789 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243231003790 P loop; other site 243231003791 GTP binding site [chemical binding]; other site 243231003792 Protein of unknown function (DUF904); Region: DUF904; pfam06005 243231003793 Cell division protein ZapA; Region: ZapA; pfam05164 243231003794 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 243231003795 phosphodiesterase; Provisional; Region: PRK12704 243231003796 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243231003797 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 243231003798 KH domain; Region: KH_1; pfam00013 243231003799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231003800 Zn2+ binding site [ion binding]; other site 243231003801 Mg2+ binding site [ion binding]; other site 243231003802 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 243231003803 putative active site [active] 243231003804 metal binding site [ion binding]; metal-binding site 243231003805 homodimer binding site [polypeptide binding]; other site 243231003806 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243231003807 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 243231003808 active site 243231003809 HIGH motif; other site 243231003810 dimer interface [polypeptide binding]; other site 243231003811 KMSKS motif; other site 243231003812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231003813 RNA binding surface [nucleotide binding]; other site 243231003814 trRNA_2; GSUR0068 243231003815 CHASE3 domain; Region: CHASE3; cl05000 243231003816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003817 dimerization interface [polypeptide binding]; other site 243231003818 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231003819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231003820 dimer interface [polypeptide binding]; other site 243231003821 putative CheW interface [polypeptide binding]; other site 243231003822 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231003823 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231003824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003825 dimerization interface [polypeptide binding]; other site 243231003826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231003827 dimer interface [polypeptide binding]; other site 243231003828 putative CheW interface [polypeptide binding]; other site 243231003829 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231003830 putative CheA interaction surface; other site 243231003831 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243231003832 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 243231003833 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 243231003834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231003835 CheD chemotactic sensory transduction; Region: CheD; pfam03975 243231003836 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 243231003837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231003838 active site 243231003839 phosphorylation site [posttranslational modification] 243231003840 intermolecular recognition site; other site 243231003841 dimerization interface [polypeptide binding]; other site 243231003842 CheB methylesterase; Region: CheB_methylest; pfam01339 243231003843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231003844 substrate binding pocket [chemical binding]; other site 243231003845 membrane-bound complex binding site; other site 243231003846 hinge residues; other site 243231003847 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 243231003848 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231003849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231003850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231003851 dimerization interface [polypeptide binding]; other site 243231003852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231003853 dimer interface [polypeptide binding]; other site 243231003854 phosphorylation site [posttranslational modification] 243231003855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231003856 ATP binding site [chemical binding]; other site 243231003857 Mg2+ binding site [ion binding]; other site 243231003858 G-X-G motif; other site 243231003859 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 243231003860 EAL domain; Region: EAL; pfam00563 243231003861 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 243231003862 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243231003863 B12 binding site [chemical binding]; other site 243231003864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231003865 FeS/SAM binding site; other site 243231003866 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 243231003867 putative active site [active] 243231003868 YdjC motif; other site 243231003869 Mg binding site [ion binding]; other site 243231003870 putative homodimer interface [polypeptide binding]; other site 243231003871 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 243231003872 conserved nucleotide sequence; similar to other Geobacter species; GSUR0154 243231003873 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 243231003874 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 243231003875 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243231003876 Surface antigen; Region: Bac_surface_Ag; pfam01103 243231003877 haemagglutination activity domain; Region: Haemagg_act; cl05436 243231003878 conserved nucleotide sequence; similar to other Geobacter species; GSUR0155 243231003879 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243231003880 catalytic residues [active] 243231003881 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 243231003882 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 243231003883 putative dimer interface [polypeptide binding]; other site 243231003884 putative anticodon binding site; other site 243231003885 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 243231003886 homodimer interface [polypeptide binding]; other site 243231003887 motif 1; other site 243231003888 motif 2; other site 243231003889 active site 243231003890 motif 3; other site 243231003891 Protein of unknown function (DUF503); Region: DUF503; pfam04456 243231003892 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 243231003893 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 243231003894 intracellular protease, PfpI family; Region: PfpI; TIGR01382 243231003895 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 243231003896 proposed catalytic triad [active] 243231003897 conserved cys residue [active] 243231003898 Cupredoxin superfamily; Region: Cupredoxin; cl19115 243231003899 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243231003900 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231003901 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231003902 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231003903 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231003904 Walker A/P-loop; other site 243231003905 ATP binding site [chemical binding]; other site 243231003906 Q-loop/lid; other site 243231003907 ABC transporter signature motif; other site 243231003908 Walker B; other site 243231003909 D-loop; other site 243231003910 H-loop/switch region; other site 243231003911 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243231003912 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231003913 FtsX-like permease family; Region: FtsX; pfam02687 243231003914 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231003915 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243231003916 FtsX-like permease family; Region: FtsX; pfam02687 243231003917 GAF domain; Region: GAF; pfam01590 243231003918 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243231003919 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 243231003920 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243231003921 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243231003922 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243231003923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003924 binding surface 243231003925 TPR motif; other site 243231003926 TPR repeat; Region: TPR_11; pfam13414 243231003927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231003928 binding surface 243231003929 TPR motif; other site 243231003930 TPR repeat; Region: TPR_11; pfam13414 243231003931 TPR repeat; Region: TPR_11; pfam13414 243231003932 YtxH-like protein; Region: YtxH; pfam12732 243231003933 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 243231003934 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 243231003935 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 243231003936 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 243231003937 catalytic residues [active] 243231003938 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 243231003939 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 243231003940 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 243231003941 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 243231003942 DNA binding site [nucleotide binding] 243231003943 active site 243231003944 conserved nucleotide sequence; similar to other Geobacter species; GSUR0156 243231003945 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 243231003946 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 243231003947 homodimer interface [polypeptide binding]; other site 243231003948 metal binding site [ion binding]; metal-binding site 243231003949 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 243231003950 homodimer interface [polypeptide binding]; other site 243231003951 active site 243231003952 putative chemical substrate binding site [chemical binding]; other site 243231003953 metal binding site [ion binding]; metal-binding site 243231003954 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 243231003955 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 243231003956 conserved nucleotide sequence; similar to other Geobacter species; GSUR0157 243231003957 conserved nucleotide sequence; similar to other Geobacter species; GSUR0158 243231003958 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 243231003959 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 243231003960 putative Iron-sulfur protein interface [polypeptide binding]; other site 243231003961 proximal heme binding site [chemical binding]; other site 243231003962 distal heme binding site [chemical binding]; other site 243231003963 putative dimer interface [polypeptide binding]; other site 243231003964 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 243231003965 L-aspartate oxidase; Provisional; Region: PRK06175 243231003966 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243231003967 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 243231003968 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 243231003969 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231003970 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 243231003971 FtsH Extracellular; Region: FtsH_ext; pfam06480 243231003972 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243231003973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243231003974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231003975 Walker A motif; other site 243231003976 ATP binding site [chemical binding]; other site 243231003977 Walker B motif; other site 243231003978 arginine finger; other site 243231003979 Peptidase family M41; Region: Peptidase_M41; pfam01434 243231003980 4-alpha-glucanotransferase; Provisional; Region: PRK14508 243231003981 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243231003982 homodimer interface [polypeptide binding]; other site 243231003983 substrate-cofactor binding pocket; other site 243231003984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231003985 catalytic residue [active] 243231003986 Protein of unknown function, DUF479; Region: DUF479; pfam04336 243231003987 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 243231003988 conserved nucleotide sequence; similar to other Geobacter species; GSUR0159 243231003989 Transcription elongation factor Spt4; Region: Spt4; cl12033 243231003990 Rhomboid family; Region: Rhomboid; cl11446 243231003991 heat shock protein HtpX; Provisional; Region: PRK01345 243231003992 Peptidase family M48; Region: Peptidase_M48; cl12018 243231003993 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 243231003994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243231003995 active site residue [active] 243231003996 AAA domain; Region: AAA_17; cl19128 243231003997 PilZ domain; Region: PilZ; pfam07238 243231003998 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 243231003999 active site 243231004000 intersubunit interface [polypeptide binding]; other site 243231004001 zinc binding site [ion binding]; other site 243231004002 Na+ binding site [ion binding]; other site 243231004003 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243231004004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231004005 Zn2+ binding site [ion binding]; other site 243231004006 Mg2+ binding site [ion binding]; other site 243231004007 TIGR03987 family protein; Region: TIGR03987 243231004008 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 243231004009 conserved nucleotide sequence; similar to other Geobacter species; GSUR0160 243231004010 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 243231004011 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 243231004012 ligand binding site [chemical binding]; other site 243231004013 NAD binding site [chemical binding]; other site 243231004014 dimerization interface [polypeptide binding]; other site 243231004015 catalytic site [active] 243231004016 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 243231004017 putative L-serine binding site [chemical binding]; other site 243231004018 Staphylococcal nuclease homologues; Region: SNc; smart00318 243231004019 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 243231004020 Catalytic site; other site 243231004021 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 243231004022 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243231004023 RNA binding site [nucleotide binding]; other site 243231004024 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243231004025 RNA binding site [nucleotide binding]; other site 243231004026 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243231004027 RNA binding site [nucleotide binding]; other site 243231004028 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243231004029 RNA binding site [nucleotide binding]; other site 243231004030 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 243231004031 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243231004032 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243231004033 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 243231004034 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 243231004035 Substrate binding site; other site 243231004036 Cupin domain; Region: Cupin_2; cl17218 243231004037 potassium/proton antiporter; Reviewed; Region: PRK05326 243231004038 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 243231004039 TrkA-C domain; Region: TrkA_C; pfam02080 243231004040 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 243231004041 putative cation:proton antiport protein; Provisional; Region: PRK10669 243231004042 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243231004043 TrkA-N domain; Region: TrkA_N; pfam02254 243231004044 TrkA-C domain; Region: TrkA_C; pfam02080 243231004045 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 243231004046 HD domain; Region: HD; pfam01966 243231004047 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 243231004048 Predicted membrane protein [Function unknown]; Region: COG2860 243231004049 UPF0126 domain; Region: UPF0126; pfam03458 243231004050 UPF0126 domain; Region: UPF0126; pfam03458 243231004051 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 243231004052 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231004053 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243231004054 active site 243231004055 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 243231004056 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 243231004057 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 243231004058 O-methyltransferase; Region: Methyltransf_2; pfam00891 243231004059 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243231004060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231004061 S-adenosylmethionine binding site [chemical binding]; other site 243231004062 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 243231004063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243231004064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231004065 Walker A/P-loop; other site 243231004066 ATP binding site [chemical binding]; other site 243231004067 Q-loop/lid; other site 243231004068 ABC transporter signature motif; other site 243231004069 Walker B; other site 243231004070 D-loop; other site 243231004071 H-loop/switch region; other site 243231004072 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 243231004073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231004074 Walker A/P-loop; other site 243231004075 ATP binding site [chemical binding]; other site 243231004076 Q-loop/lid; other site 243231004077 ABC transporter signature motif; other site 243231004078 Walker B; other site 243231004079 D-loop; other site 243231004080 H-loop/switch region; other site 243231004081 Domain of unknown function (DUF329); Region: DUF329; pfam03884 243231004082 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 243231004083 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243231004084 active site 243231004085 HIGH motif; other site 243231004086 KMSKS motif; other site 243231004087 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231004088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004089 active site 243231004090 phosphorylation site [posttranslational modification] 243231004091 intermolecular recognition site; other site 243231004092 dimerization interface [polypeptide binding]; other site 243231004093 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 243231004094 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 243231004095 active site 243231004096 Zn binding site [ion binding]; other site 243231004097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004098 TPR motif; other site 243231004099 binding surface 243231004100 conserved nucleotide sequence; similar to other Geobacter species; GSUR0161 243231004101 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243231004102 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 243231004103 Walker A/P-loop; other site 243231004104 ATP binding site [chemical binding]; other site 243231004105 Q-loop/lid; other site 243231004106 ABC transporter signature motif; other site 243231004107 Walker B; other site 243231004108 D-loop; other site 243231004109 H-loop/switch region; other site 243231004110 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231004111 Cytochrome c7; Region: Cytochrome_C7; cl19206 243231004112 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231004113 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231004114 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 243231004115 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 243231004116 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 243231004117 zinc binding site [ion binding]; other site 243231004118 putative ligand binding site [chemical binding]; other site 243231004119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231004120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004121 active site 243231004122 phosphorylation site [posttranslational modification] 243231004123 intermolecular recognition site; other site 243231004124 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 243231004125 active site 243231004126 metal binding site [ion binding]; metal-binding site 243231004127 homotetramer interface [polypeptide binding]; other site 243231004128 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 243231004129 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 243231004130 tandem repeat interface [polypeptide binding]; other site 243231004131 oligomer interface [polypeptide binding]; other site 243231004132 active site residues [active] 243231004133 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 243231004134 putative subunit interface; other site 243231004135 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 243231004136 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 243231004137 putative active site [active] 243231004138 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 243231004139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231004140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231004141 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243231004142 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231004143 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231004144 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231004145 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243231004146 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 243231004147 active site 243231004148 FMN binding site [chemical binding]; other site 243231004149 substrate binding site [chemical binding]; other site 243231004150 3Fe-4S cluster binding site [ion binding]; other site 243231004151 PilZ domain; Region: PilZ; pfam07238 243231004152 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 243231004153 aspartate aminotransferase; Provisional; Region: PRK05764 243231004154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231004155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231004156 homodimer interface [polypeptide binding]; other site 243231004157 catalytic residue [active] 243231004158 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 243231004159 active site 243231004160 (T/H)XGH motif; other site 243231004161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231004162 S-adenosylmethionine binding site [chemical binding]; other site 243231004163 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 243231004164 active site 243231004165 intersubunit interface [polypeptide binding]; other site 243231004166 zinc binding site [ion binding]; other site 243231004167 Na+ binding site [ion binding]; other site 243231004168 conserved nucleotide sequence; similar to other Geobacter species; GSUR0162 243231004169 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 243231004170 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231004171 Zn2+ binding site [ion binding]; other site 243231004172 Mg2+ binding site [ion binding]; other site 243231004173 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 243231004174 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 243231004175 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 243231004176 PAS domain; Region: PAS_8; pfam13188 243231004177 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231004178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004179 putative active site [active] 243231004180 heme pocket [chemical binding]; other site 243231004181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004182 dimer interface [polypeptide binding]; other site 243231004183 phosphorylation site [posttranslational modification] 243231004184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004185 ATP binding site [chemical binding]; other site 243231004186 Mg2+ binding site [ion binding]; other site 243231004187 G-X-G motif; other site 243231004188 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231004189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004190 active site 243231004191 phosphorylation site [posttranslational modification] 243231004192 intermolecular recognition site; other site 243231004193 dimerization interface [polypeptide binding]; other site 243231004194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231004195 Walker A motif; other site 243231004196 ATP binding site [chemical binding]; other site 243231004197 Walker B motif; other site 243231004198 arginine finger; other site 243231004199 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231004200 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004201 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004202 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004203 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004204 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004205 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004206 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004207 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004208 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004209 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004210 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004211 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004212 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004213 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004214 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004215 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231004216 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231004217 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 243231004218 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 243231004219 BNR repeat-like domain; Region: BNR_2; pfam13088 243231004220 Asp-box motif; other site 243231004221 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 243231004222 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243231004223 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243231004224 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 243231004225 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243231004226 Cu(I) binding site [ion binding]; other site 243231004227 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243231004228 Cu(I) binding site [ion binding]; other site 243231004229 Cytochrome c; Region: Cytochrom_C; pfam00034 243231004230 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243231004231 NosL; Region: NosL; cl01769 243231004232 FtsX-like permease family; Region: FtsX; pfam02687 243231004233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231004234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231004235 Walker A/P-loop; other site 243231004236 ATP binding site [chemical binding]; other site 243231004237 Q-loop/lid; other site 243231004238 ABC transporter signature motif; other site 243231004239 Walker B; other site 243231004240 D-loop; other site 243231004241 H-loop/switch region; other site 243231004242 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 243231004243 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 243231004244 putative binding surface; other site 243231004245 active site 243231004246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004247 dimer interface [polypeptide binding]; other site 243231004248 phosphorylation site [posttranslational modification] 243231004249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004250 ATP binding site [chemical binding]; other site 243231004251 Mg2+ binding site [ion binding]; other site 243231004252 G-X-G motif; other site 243231004253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004254 active site 243231004255 phosphorylation site [posttranslational modification] 243231004256 intermolecular recognition site; other site 243231004257 dimerization interface [polypeptide binding]; other site 243231004258 GTP-binding protein LepA; Provisional; Region: PRK05433 243231004259 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243231004260 G1 box; other site 243231004261 putative GEF interaction site [polypeptide binding]; other site 243231004262 GTP/Mg2+ binding site [chemical binding]; other site 243231004263 Switch I region; other site 243231004264 G2 box; other site 243231004265 G3 box; other site 243231004266 Switch II region; other site 243231004267 G4 box; other site 243231004268 G5 box; other site 243231004269 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243231004270 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243231004271 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243231004272 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243231004273 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 243231004274 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 243231004275 Catalytic site [active] 243231004276 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 243231004277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243231004278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231004279 LysR substrate binding domain; Region: LysR_substrate; pfam03466 243231004280 dimerization interface [polypeptide binding]; other site 243231004281 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243231004282 Uncharacterized conserved protein [Function unknown]; Region: COG5276 243231004283 LVIVD repeat; Region: LVIVD; pfam08309 243231004284 conserved nucleotide sequence; similar to other Geobacter species; GSUR0163 243231004285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231004286 active site 243231004287 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 243231004288 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 243231004289 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 243231004290 dihydroorotase; Validated; Region: pyrC; PRK09357 243231004291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243231004292 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 243231004293 active site 243231004294 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 243231004295 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 243231004296 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 243231004297 catalytic site [active] 243231004298 subunit interface [polypeptide binding]; other site 243231004299 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 243231004300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231004301 FeS/SAM binding site; other site 243231004302 Protein of unknown function, DUF486; Region: DUF486; cl01236 243231004303 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 243231004304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243231004305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243231004306 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 243231004307 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243231004308 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243231004309 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 243231004310 IMP binding site; other site 243231004311 dimer interface [polypeptide binding]; other site 243231004312 partial ornithine binding site; other site 243231004313 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243231004314 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243231004315 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243231004316 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 243231004317 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 243231004318 PDGLE domain; Region: PDGLE; pfam13190 243231004319 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 243231004320 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243231004321 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243231004322 Walker A/P-loop; other site 243231004323 ATP binding site [chemical binding]; other site 243231004324 Q-loop/lid; other site 243231004325 ABC transporter signature motif; other site 243231004326 Walker B; other site 243231004327 D-loop; other site 243231004328 H-loop/switch region; other site 243231004329 Alginate export; Region: Alginate_exp; pfam13372 243231004330 NosL; Region: NosL; cl01769 243231004331 PAS domain S-box; Region: sensory_box; TIGR00229 243231004332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004333 putative active site [active] 243231004334 heme pocket [chemical binding]; other site 243231004335 PAS domain; Region: PAS; smart00091 243231004336 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231004337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004338 dimer interface [polypeptide binding]; other site 243231004339 phosphorylation site [posttranslational modification] 243231004340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004341 ATP binding site [chemical binding]; other site 243231004342 Mg2+ binding site [ion binding]; other site 243231004343 G-X-G motif; other site 243231004344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231004345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004346 active site 243231004347 phosphorylation site [posttranslational modification] 243231004348 intermolecular recognition site; other site 243231004349 dimerization interface [polypeptide binding]; other site 243231004350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004351 active site 243231004352 phosphorylation site [posttranslational modification] 243231004353 intermolecular recognition site; other site 243231004354 dimerization interface [polypeptide binding]; other site 243231004355 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231004356 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231004357 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231004358 dimer interface [polypeptide binding]; other site 243231004359 putative CheW interface [polypeptide binding]; other site 243231004360 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243231004361 anti sigma factor interaction site; other site 243231004362 regulatory phosphorylation site [posttranslational modification]; other site 243231004363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004364 active site 243231004365 phosphorylation site [posttranslational modification] 243231004366 intermolecular recognition site; other site 243231004367 dimerization interface [polypeptide binding]; other site 243231004368 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 243231004369 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243231004370 putative binding surface; other site 243231004371 active site 243231004372 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 243231004373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004374 ATP binding site [chemical binding]; other site 243231004375 Mg2+ binding site [ion binding]; other site 243231004376 G-X-G motif; other site 243231004377 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 243231004378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004379 active site 243231004380 phosphorylation site [posttranslational modification] 243231004381 intermolecular recognition site; other site 243231004382 dimerization interface [polypeptide binding]; other site 243231004383 PAS domain S-box; Region: sensory_box; TIGR00229 243231004384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004385 putative active site [active] 243231004386 heme pocket [chemical binding]; other site 243231004387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 243231004388 Histidine kinase; Region: HisKA_3; pfam07730 243231004389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004390 ATP binding site [chemical binding]; other site 243231004391 Mg2+ binding site [ion binding]; other site 243231004392 G-X-G motif; other site 243231004393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231004394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004395 active site 243231004396 phosphorylation site [posttranslational modification] 243231004397 intermolecular recognition site; other site 243231004398 dimerization interface [polypeptide binding]; other site 243231004399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243231004400 DNA binding residues [nucleotide binding] 243231004401 dimerization interface [polypeptide binding]; other site 243231004402 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231004403 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231004404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004405 dimerization interface [polypeptide binding]; other site 243231004406 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231004407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231004408 dimer interface [polypeptide binding]; other site 243231004409 putative CheW interface [polypeptide binding]; other site 243231004410 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231004411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 243231004412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004413 dimer interface [polypeptide binding]; other site 243231004414 phosphorylation site [posttranslational modification] 243231004415 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004416 ATP binding site [chemical binding]; other site 243231004417 Mg2+ binding site [ion binding]; other site 243231004418 G-X-G motif; other site 243231004419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004420 active site 243231004421 phosphorylation site [posttranslational modification] 243231004422 intermolecular recognition site; other site 243231004423 conserved nucleotide sequence; similar to other Geobacter species; GSUR0164 243231004424 Transposase domain (DUF772); Region: DUF772; pfam05598 243231004425 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231004426 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243231004427 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243231004428 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243231004429 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231004430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004431 dimerization interface [polypeptide binding]; other site 243231004432 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231004433 dimer interface [polypeptide binding]; other site 243231004434 putative CheW interface [polypeptide binding]; other site 243231004435 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231004436 putative CheA interaction surface; other site 243231004437 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231004438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231004439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004440 dimerization interface [polypeptide binding]; other site 243231004441 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231004442 dimer interface [polypeptide binding]; other site 243231004443 putative CheW interface [polypeptide binding]; other site 243231004444 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231004445 putative CheA interaction surface; other site 243231004446 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243231004447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231004448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004449 dimerization interface [polypeptide binding]; other site 243231004450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004451 dimer interface [polypeptide binding]; other site 243231004452 phosphorylation site [posttranslational modification] 243231004453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004454 ATP binding site [chemical binding]; other site 243231004455 Mg2+ binding site [ion binding]; other site 243231004456 G-X-G motif; other site 243231004457 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231004458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004459 active site 243231004460 phosphorylation site [posttranslational modification] 243231004461 intermolecular recognition site; other site 243231004462 dimerization interface [polypeptide binding]; other site 243231004463 Hpt domain; Region: Hpt; pfam01627 243231004464 conserved nucleotide sequence; similar to other Geobacter species; GSUR0165 243231004465 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004466 dimerization interface [polypeptide binding]; other site 243231004467 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231004468 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231004469 dimer interface [polypeptide binding]; other site 243231004470 putative CheW interface [polypeptide binding]; other site 243231004471 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 243231004472 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231004473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004474 dimerization interface [polypeptide binding]; other site 243231004475 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231004476 dimer interface [polypeptide binding]; other site 243231004477 putative CheW interface [polypeptide binding]; other site 243231004478 palindrome; GSUR0166 243231004479 glutamate dehydrogenase; Provisional; Region: PRK09414 243231004480 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 243231004481 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 243231004482 NAD(P) binding site [chemical binding]; other site 243231004483 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 243231004484 active site 243231004485 Phosphotransferase enzyme family; Region: APH; pfam01636 243231004486 active site 243231004487 ATP binding site [chemical binding]; other site 243231004488 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243231004489 substrate binding site [chemical binding]; other site 243231004490 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 243231004491 Ferritin-like domain; Region: Ferritin; pfam00210 243231004492 ferroxidase diiron center [ion binding]; other site 243231004493 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 243231004494 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 243231004495 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 243231004496 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 243231004497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231004498 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 243231004499 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243231004500 active site 243231004501 dimer interface [polypeptide binding]; other site 243231004502 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243231004503 dimer interface [polypeptide binding]; other site 243231004504 active site 243231004505 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 243231004506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231004507 FeS/SAM binding site; other site 243231004508 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 243231004509 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 243231004510 Uncharacterized conserved protein [Function unknown]; Region: COG0398 243231004511 mercuric reductase; Validated; Region: PRK06370 243231004512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231004513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231004514 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243231004515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004516 active site 243231004517 phosphorylation site [posttranslational modification] 243231004518 intermolecular recognition site; other site 243231004519 dimerization interface [polypeptide binding]; other site 243231004520 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243231004521 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243231004522 substrate binding pocket [chemical binding]; other site 243231004523 chain length determination region; other site 243231004524 substrate-Mg2+ binding site; other site 243231004525 catalytic residues [active] 243231004526 aspartate-rich region 1; other site 243231004527 active site lid residues [active] 243231004528 aspartate-rich region 2; other site 243231004529 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 243231004530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004531 dimer interface [polypeptide binding]; other site 243231004532 phosphorylation site [posttranslational modification] 243231004533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004534 ATP binding site [chemical binding]; other site 243231004535 Mg2+ binding site [ion binding]; other site 243231004536 G-X-G motif; other site 243231004537 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231004538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004539 active site 243231004540 phosphorylation site [posttranslational modification] 243231004541 intermolecular recognition site; other site 243231004542 dimerization interface [polypeptide binding]; other site 243231004543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231004544 Walker A motif; other site 243231004545 ATP binding site [chemical binding]; other site 243231004546 Walker B motif; other site 243231004547 arginine finger; other site 243231004548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231004549 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243231004550 catalytic residues [active] 243231004551 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 243231004552 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 243231004553 active site 243231004554 conserved nucleotide sequence; similar to other Geobacter species; GSUR0167 243231004555 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 243231004556 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 243231004557 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 243231004558 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 243231004559 generic binding surface II; other site 243231004560 ssDNA binding site; other site 243231004561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231004562 ATP binding site [chemical binding]; other site 243231004563 putative Mg++ binding site [ion binding]; other site 243231004564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231004565 nucleotide binding region [chemical binding]; other site 243231004566 ATP-binding site [chemical binding]; other site 243231004567 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 243231004568 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 243231004569 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 243231004570 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 243231004571 active site 243231004572 nucleotide binding site [chemical binding]; other site 243231004573 HIGH motif; other site 243231004574 KMSKS motif; other site 243231004575 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243231004576 Outer membrane efflux protein; Region: OEP; pfam02321 243231004577 Outer membrane efflux protein; Region: OEP; pfam02321 243231004578 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243231004579 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231004580 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243231004581 MMPL family; Region: MMPL; cl14618 243231004582 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231004583 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231004584 heme-binding residues [chemical binding]; other site 243231004585 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 243231004586 three overlapping hairpins; GSUR0168 243231004587 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 243231004588 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243231004589 metal-binding site [ion binding] 243231004590 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 243231004591 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 243231004592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231004593 FtsX-like permease family; Region: FtsX; pfam02687 243231004594 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231004595 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231004596 Walker A/P-loop; other site 243231004597 ATP binding site [chemical binding]; other site 243231004598 Q-loop/lid; other site 243231004599 ABC transporter signature motif; other site 243231004600 Walker B; other site 243231004601 D-loop; other site 243231004602 H-loop/switch region; other site 243231004603 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 243231004604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231004605 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 243231004606 dimerization interface [polypeptide binding]; other site 243231004607 substrate binding pocket [chemical binding]; other site 243231004608 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 243231004609 catalytic triad [active] 243231004610 dimer interface [polypeptide binding]; other site 243231004611 conserved cis-peptide bond; other site 243231004612 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 243231004613 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 243231004614 active site 243231004615 Predicted transcriptional regulator [Transcription]; Region: COG1959 243231004616 Rrf2 family protein; Region: rrf2_super; TIGR00738 243231004617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231004618 substrate binding pocket [chemical binding]; other site 243231004619 membrane-bound complex binding site; other site 243231004620 hinge residues; other site 243231004621 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243231004622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231004623 dimer interface [polypeptide binding]; other site 243231004624 conserved gate region; other site 243231004625 putative PBP binding loops; other site 243231004626 ABC-ATPase subunit interface; other site 243231004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231004628 dimer interface [polypeptide binding]; other site 243231004629 conserved gate region; other site 243231004630 putative PBP binding loops; other site 243231004631 ABC-ATPase subunit interface; other site 243231004632 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 243231004633 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 243231004634 Walker A/P-loop; other site 243231004635 ATP binding site [chemical binding]; other site 243231004636 Q-loop/lid; other site 243231004637 ABC transporter signature motif; other site 243231004638 Walker B; other site 243231004639 D-loop; other site 243231004640 H-loop/switch region; other site 243231004641 TOBE-like domain; Region: TOBE_3; pfam12857 243231004642 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 243231004643 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 243231004644 ATP binding site [chemical binding]; other site 243231004645 substrate interface [chemical binding]; other site 243231004646 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243231004647 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 243231004648 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231004649 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231004650 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 243231004651 CPxP motif; other site 243231004652 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 243231004653 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 243231004654 Transposase; Region: HTH_Tnp_1; cl17663 243231004655 putative transposase OrfB; Reviewed; Region: PHA02517 243231004656 HTH-like domain; Region: HTH_21; pfam13276 243231004657 Integrase core domain; Region: rve; pfam00665 243231004658 Integrase core domain; Region: rve_3; cl15866 243231004659 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 243231004660 homodimer interface [polypeptide binding]; other site 243231004661 chemical substrate binding site [chemical binding]; other site 243231004662 oligomer interface [polypeptide binding]; other site 243231004663 metal binding site [ion binding]; metal-binding site 243231004664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231004665 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 243231004666 Walker A motif; other site 243231004667 ATP binding site [chemical binding]; other site 243231004668 Walker B motif; other site 243231004669 Uncharacterized conserved protein [Function unknown]; Region: COG3410 243231004670 Predicted transcriptional regulator [Transcription]; Region: COG2932 243231004671 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243231004672 Catalytic site [active] 243231004673 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 243231004674 PLD-like domain; Region: PLDc_2; pfam13091 243231004675 putative homodimer interface [polypeptide binding]; other site 243231004676 putative active site [active] 243231004677 catalytic site [active] 243231004678 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 243231004679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231004680 ATP binding site [chemical binding]; other site 243231004681 putative Mg++ binding site [ion binding]; other site 243231004682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231004683 nucleotide binding region [chemical binding]; other site 243231004684 ATP-binding site [chemical binding]; other site 243231004685 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 243231004686 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 243231004687 SIR2-like domain; Region: SIR2_2; pfam13289 243231004688 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 243231004689 5' RNA guide strand anchoring site; other site 243231004690 active site 243231004691 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 243231004692 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 243231004693 putative active site [active] 243231004694 putative NTP binding site [chemical binding]; other site 243231004695 putative nucleic acid binding site [nucleotide binding]; other site 243231004696 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 243231004697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243231004698 active site 243231004699 Restriction endonuclease; Region: Mrr_cat; pfam04471 243231004700 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 243231004701 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243231004702 conserved nucleotide sequence; similar to other Geobacter species; GSUR0169 243231004703 conserved nucleotide sequence; similar to other Geobacter species; GSUR0170 243231004704 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 243231004705 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 243231004706 conserved nucleotide sequence; similar to other Geobacter species; GSUR0171 243231004707 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 243231004708 putative active site [active] 243231004709 conserved nucleotide sequence; similar to other Geobacter species; GSUR0172 243231004710 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 243231004711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243231004712 active site 243231004713 catalytic tetrad [active] 243231004714 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 243231004715 conserved nucleotide sequence; similar to other Geobacter species; GSUR4001 243231004716 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 243231004717 active site 243231004718 FMN binding site [chemical binding]; other site 243231004719 substrate binding site [chemical binding]; other site 243231004720 homotetramer interface [polypeptide binding]; other site 243231004721 catalytic residue [active] 243231004722 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243231004723 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243231004724 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 243231004725 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231004726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231004727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004728 dimerization interface [polypeptide binding]; other site 243231004729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231004730 dimer interface [polypeptide binding]; other site 243231004731 putative CheW interface [polypeptide binding]; other site 243231004732 conserved nucleotide sequence; similar to other Geobacter species; GSUR0173 243231004733 conserved nucleotide sequence; similar to other Geobacter species; GSUR0174 243231004734 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 243231004735 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 243231004736 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 243231004737 substrate binding site [chemical binding]; other site 243231004738 oxyanion hole (OAH) forming residues; other site 243231004739 trimer interface [polypeptide binding]; other site 243231004740 Beta-lactamase; Region: Beta-lactamase; pfam00144 243231004741 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243231004742 metal binding site 2 [ion binding]; metal-binding site 243231004743 putative DNA binding helix; other site 243231004744 metal binding site 1 [ion binding]; metal-binding site 243231004745 dimer interface [polypeptide binding]; other site 243231004746 structural Zn2+ binding site [ion binding]; other site 243231004747 conserved nucleotide sequence; similar to other Geobacter species; GSUR4002 243231004748 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 243231004749 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 243231004750 G1 box; other site 243231004751 GTP/Mg2+ binding site [chemical binding]; other site 243231004752 Switch I region; other site 243231004753 G2 box; other site 243231004754 G3 box; other site 243231004755 Switch II region; other site 243231004756 G4 box; other site 243231004757 G5 box; other site 243231004758 Nucleoside recognition; Region: Gate; pfam07670 243231004759 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 243231004760 Nucleoside recognition; Region: Gate; pfam07670 243231004761 DNA polymerase II large subunit; Provisional; Region: PRK14714 243231004762 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 243231004763 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 243231004764 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 243231004765 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 243231004766 active site 243231004767 catalytic site [active] 243231004768 substrate binding site [chemical binding]; other site 243231004769 helicase Cas3; Provisional; Region: PRK09694 243231004770 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 243231004771 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 243231004772 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 243231004773 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 243231004774 CT1975-like protein; Region: Cas_CT1975; pfam09344 243231004775 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 243231004776 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 243231004777 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243231004778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231004779 non-specific DNA binding site [nucleotide binding]; other site 243231004780 salt bridge; other site 243231004781 sequence-specific DNA binding site [nucleotide binding]; other site 243231004782 BH3 interacting domain (BID); Region: BID; pfam06393 243231004783 Fic/DOC family; Region: Fic; cl00960 243231004784 mobile mystery protein B; Region: mob_myst_B; TIGR02613 243231004785 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 243231004786 putative ssRNA endonuclease; Provisional; Region: PRK11558 243231004787 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 243231004788 dimer interface [polypeptide binding]; other site 243231004789 hexamer interface [polypeptide binding]; other site 243231004790 Domain 2 interface [polypeptide binding]; other site 243231004791 Domain 3 interface [polypeptide binding]; other site 243231004792 trinuclear Cu binding site [ion binding]; other site 243231004793 Cupredoxin superfamily; Region: Cupredoxin; cl19115 243231004794 Cupredoxin superfamily; Region: Cupredoxin; cl19115 243231004795 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231004796 Interdomain contacts; other site 243231004797 Cytokine receptor motif; other site 243231004798 Domain of unknown function (DUF4655); Region: DUF4655; pfam15548 243231004799 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 243231004800 ligand binding site [chemical binding]; other site 243231004801 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 243231004802 Cu(I) binding site [ion binding]; other site 243231004803 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 243231004804 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 243231004805 oligomer interface [polypeptide binding]; other site 243231004806 metal binding site [ion binding]; metal-binding site 243231004807 metal binding site [ion binding]; metal-binding site 243231004808 Cl binding site [ion binding]; other site 243231004809 aspartate ring; other site 243231004810 basic sphincter; other site 243231004811 putative hydrophobic gate; other site 243231004812 periplasmic entrance; other site 243231004813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004814 PAS domain; Region: PAS_9; pfam13426 243231004815 putative active site [active] 243231004816 heme pocket [chemical binding]; other site 243231004817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231004818 metal binding site [ion binding]; metal-binding site 243231004819 active site 243231004820 I-site; other site 243231004821 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 243231004822 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 243231004823 active site 243231004824 PHP Thumb interface [polypeptide binding]; other site 243231004825 metal binding site [ion binding]; metal-binding site 243231004826 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 243231004827 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 243231004828 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 243231004829 generic binding surface II; other site 243231004830 generic binding surface I; other site 243231004831 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 243231004832 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 243231004833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231004834 RNA binding surface [nucleotide binding]; other site 243231004835 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 243231004836 active site 243231004837 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 243231004838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231004839 FeS/SAM binding site; other site 243231004840 Rdx family; Region: Rdx; pfam10262 243231004841 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243231004842 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 243231004843 Walker A motif; other site 243231004844 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243231004845 trimerization site [polypeptide binding]; other site 243231004846 active site 243231004847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243231004848 DNA binding residues [nucleotide binding] 243231004849 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 243231004850 Domain of unknown function DUF302; Region: DUF302; cl01364 243231004851 Uncharacterized conserved protein [Function unknown]; Region: COG1433 243231004852 PAS fold; Region: PAS_4; pfam08448 243231004853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004854 putative active site [active] 243231004855 heme pocket [chemical binding]; other site 243231004856 PAS domain S-box; Region: sensory_box; TIGR00229 243231004857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004858 putative active site [active] 243231004859 heme pocket [chemical binding]; other site 243231004860 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231004861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231004862 putative active site [active] 243231004863 heme pocket [chemical binding]; other site 243231004864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004865 dimer interface [polypeptide binding]; other site 243231004866 phosphorylation site [posttranslational modification] 243231004867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004868 ATP binding site [chemical binding]; other site 243231004869 Mg2+ binding site [ion binding]; other site 243231004870 G-X-G motif; other site 243231004871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004872 active site 243231004873 phosphorylation site [posttranslational modification] 243231004874 intermolecular recognition site; other site 243231004875 dimerization interface [polypeptide binding]; other site 243231004876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004877 active site 243231004878 phosphorylation site [posttranslational modification] 243231004879 intermolecular recognition site; other site 243231004880 dimerization interface [polypeptide binding]; other site 243231004881 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 243231004882 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 243231004883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004884 active site 243231004885 phosphorylation site [posttranslational modification] 243231004886 intermolecular recognition site; other site 243231004887 dimerization interface [polypeptide binding]; other site 243231004888 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243231004889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231004890 non-specific DNA binding site [nucleotide binding]; other site 243231004891 salt bridge; other site 243231004892 sequence-specific DNA binding site [nucleotide binding]; other site 243231004893 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 243231004894 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231004895 RNA binding surface [nucleotide binding]; other site 243231004896 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 243231004897 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 243231004898 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 243231004899 active site 243231004900 metal binding site [ion binding]; metal-binding site 243231004901 DNA binding site [nucleotide binding] 243231004902 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 243231004903 AAA domain; Region: AAA_23; pfam13476 243231004904 Walker A/P-loop; other site 243231004905 ATP binding site [chemical binding]; other site 243231004906 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 243231004907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231004908 ABC transporter signature motif; other site 243231004909 Walker B; other site 243231004910 D-loop; other site 243231004911 H-loop/switch region; other site 243231004912 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 243231004913 nucleotide binding site/active site [active] 243231004914 HIT family signature motif; other site 243231004915 catalytic residue [active] 243231004916 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243231004917 conserved nucleotide sequence; similar to other Geobacter species; GSUR0069 243231004918 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 243231004919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004920 ATP binding site [chemical binding]; other site 243231004921 Mg2+ binding site [ion binding]; other site 243231004922 G-X-G motif; other site 243231004923 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 243231004924 anti sigma factor interaction site; other site 243231004925 regulatory phosphorylation site [posttranslational modification]; other site 243231004926 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 243231004927 Na binding site [ion binding]; other site 243231004928 GAF domain; Region: GAF_2; pfam13185 243231004929 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 243231004930 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243231004931 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 243231004932 Predicted kinase [General function prediction only]; Region: COG0645 243231004933 AAA domain; Region: AAA_33; pfam13671 243231004934 TPR repeat; Region: TPR_11; pfam13414 243231004935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004936 binding surface 243231004937 TPR motif; other site 243231004938 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243231004939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004940 TPR motif; other site 243231004941 binding surface 243231004942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004943 binding surface 243231004944 TPR motif; other site 243231004945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004946 binding surface 243231004947 TPR motif; other site 243231004948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004949 binding surface 243231004950 TPR motif; other site 243231004951 TPR repeat; Region: TPR_11; pfam13414 243231004952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231004953 binding surface 243231004954 TPR motif; other site 243231004955 TPR repeat; Region: TPR_11; pfam13414 243231004956 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 243231004957 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 243231004958 peptide binding site [polypeptide binding]; other site 243231004959 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243231004960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231004961 dimer interface [polypeptide binding]; other site 243231004962 conserved gate region; other site 243231004963 putative PBP binding loops; other site 243231004964 ABC-ATPase subunit interface; other site 243231004965 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 243231004966 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 243231004967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231004968 dimer interface [polypeptide binding]; other site 243231004969 conserved gate region; other site 243231004970 putative PBP binding loops; other site 243231004971 ABC-ATPase subunit interface; other site 243231004972 Peptidase family M48; Region: Peptidase_M48; pfam01435 243231004973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231004974 Walker A motif; other site 243231004975 ATP binding site [chemical binding]; other site 243231004976 Walker B motif; other site 243231004977 arginine finger; other site 243231004978 conserved nucleotide sequence; similar to other Geobacter species; GSUR0175 243231004979 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 243231004980 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231004981 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231004982 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 243231004983 active site clefts [active] 243231004984 zinc binding site [ion binding]; other site 243231004985 dimer interface [polypeptide binding]; other site 243231004986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231004987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231004988 dimerization interface [polypeptide binding]; other site 243231004989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231004990 dimer interface [polypeptide binding]; other site 243231004991 phosphorylation site [posttranslational modification] 243231004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231004993 ATP binding site [chemical binding]; other site 243231004994 Mg2+ binding site [ion binding]; other site 243231004995 G-X-G motif; other site 243231004996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231004997 active site 243231004998 phosphorylation site [posttranslational modification] 243231004999 intermolecular recognition site; other site 243231005000 dimerization interface [polypeptide binding]; other site 243231005001 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243231005002 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 243231005003 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243231005004 N-terminal plug; other site 243231005005 ligand-binding site [chemical binding]; other site 243231005006 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 243231005007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231005008 FeS/SAM binding site; other site 243231005009 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243231005010 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 243231005011 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 243231005012 active site 243231005013 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 243231005014 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243231005015 minor groove reading motif; other site 243231005016 helix-hairpin-helix signature motif; other site 243231005017 substrate binding pocket [chemical binding]; other site 243231005018 active site 243231005019 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 243231005020 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 243231005021 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 243231005022 TRAM domain; Region: TRAM; cl01282 243231005023 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 243231005024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231005025 S-adenosylmethionine binding site [chemical binding]; other site 243231005026 HEAT repeats; Region: HEAT_2; pfam13646 243231005027 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 243231005028 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 243231005029 DXD motif; other site 243231005030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005031 binding surface 243231005032 TPR repeat; Region: TPR_11; pfam13414 243231005033 TPR motif; other site 243231005034 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243231005035 putative active site [active] 243231005036 putative metal binding site [ion binding]; other site 243231005037 TPR repeat; Region: TPR_11; pfam13414 243231005038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005039 binding surface 243231005040 TPR motif; other site 243231005041 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243231005042 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 243231005043 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 243231005044 prolyl-tRNA synthetase; Provisional; Region: PRK09194 243231005045 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 243231005046 dimer interface [polypeptide binding]; other site 243231005047 motif 1; other site 243231005048 active site 243231005049 motif 2; other site 243231005050 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 243231005051 putative deacylase active site [active] 243231005052 motif 3; other site 243231005053 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 243231005054 anticodon binding site; other site 243231005055 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 243231005056 active site 243231005057 dimer interface [polypeptide binding]; other site 243231005058 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 243231005059 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 243231005060 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243231005061 conserved nucleotide sequence; similar to other Geobacter species; GSUR0176 243231005062 conserved nucleotide sequence; similar to other Geobacter species; GSUR0177 243231005063 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 243231005064 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 243231005065 dimer interface [polypeptide binding]; other site 243231005066 anticodon binding site; other site 243231005067 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243231005068 homodimer interface [polypeptide binding]; other site 243231005069 motif 1; other site 243231005070 active site 243231005071 motif 2; other site 243231005072 GAD domain; Region: GAD; pfam02938 243231005073 motif 3; other site 243231005074 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 243231005075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231005076 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 243231005077 malate dehydrogenase; Reviewed; Region: PRK06223 243231005078 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 243231005079 NAD(P) binding site [chemical binding]; other site 243231005080 dimer interface [polypeptide binding]; other site 243231005081 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243231005082 substrate binding site [chemical binding]; other site 243231005083 conserved palindrome; GSUR0178 243231005084 conserved nucleotide sequence; similar to other Geobacter species; GSUR0179 243231005085 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231005086 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231005087 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 243231005088 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243231005089 dimer interface [polypeptide binding]; other site 243231005090 PYR/PP interface [polypeptide binding]; other site 243231005091 TPP binding site [chemical binding]; other site 243231005092 substrate binding site [chemical binding]; other site 243231005093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231005094 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 243231005095 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 243231005096 TPP-binding site [chemical binding]; other site 243231005097 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 243231005098 palindrome; GSUR0180 243231005099 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231005100 Zn2+ binding site [ion binding]; other site 243231005101 Mg2+ binding site [ion binding]; other site 243231005102 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 243231005103 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243231005104 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 243231005105 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 243231005106 Uncharacterized conserved protein [Function unknown]; Region: COG4095 243231005107 LemA family; Region: LemA; pfam04011 243231005108 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 243231005109 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 243231005110 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 243231005111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231005112 putative substrate translocation pore; other site 243231005113 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 243231005114 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231005115 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231005116 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243231005117 Outer membrane efflux protein; Region: OEP; pfam02321 243231005118 Outer membrane efflux protein; Region: OEP; pfam02321 243231005119 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243231005120 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243231005121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005122 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243231005123 TPR motif; other site 243231005124 binding surface 243231005125 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243231005126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005127 binding surface 243231005128 TPR motif; other site 243231005129 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243231005130 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243231005131 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243231005132 catalytic residue [active] 243231005133 ribonuclease R; Region: RNase_R; TIGR02063 243231005134 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 243231005135 RNA binding site [nucleotide binding]; other site 243231005136 RNB domain; Region: RNB; pfam00773 243231005137 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 243231005138 RNA binding site [nucleotide binding]; other site 243231005139 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 243231005140 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 243231005141 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 243231005142 active site 243231005143 Riboflavin kinase; Region: Flavokinase; pfam01687 243231005144 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 243231005145 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 243231005146 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 243231005147 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 243231005148 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 243231005149 shikimate binding site; other site 243231005150 NAD(P) binding site [chemical binding]; other site 243231005151 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 243231005152 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231005153 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243231005154 Walker A motif; other site 243231005155 ATP binding site [chemical binding]; other site 243231005156 Walker B motif; other site 243231005157 conserved nucleotide sequence; similar to other Geobacter species; GSUR0181 243231005158 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 243231005159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243231005160 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 243231005161 Walker A motif; other site 243231005162 ATP binding site [chemical binding]; other site 243231005163 Walker B motif; other site 243231005164 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243231005165 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243231005166 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243231005167 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231005168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005169 putative active site [active] 243231005170 heme pocket [chemical binding]; other site 243231005171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231005172 dimer interface [polypeptide binding]; other site 243231005173 phosphorylation site [posttranslational modification] 243231005174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231005175 ATP binding site [chemical binding]; other site 243231005176 Mg2+ binding site [ion binding]; other site 243231005177 G-X-G motif; other site 243231005178 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231005179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005180 active site 243231005181 phosphorylation site [posttranslational modification] 243231005182 intermolecular recognition site; other site 243231005183 dimerization interface [polypeptide binding]; other site 243231005184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231005185 Walker A motif; other site 243231005186 ATP binding site [chemical binding]; other site 243231005187 Walker B motif; other site 243231005188 arginine finger; other site 243231005189 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231005190 conserved nucleotide sequence; similar to other Geobacter species; GSUR0182 243231005191 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 243231005192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005193 TPR motif; other site 243231005194 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243231005195 binding surface 243231005196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005197 binding surface 243231005198 TPR motif; other site 243231005199 Acyltransferase family; Region: Acyl_transf_3; cl19154 243231005200 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243231005201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243231005202 Walker A/P-loop; other site 243231005203 ATP binding site [chemical binding]; other site 243231005204 Q-loop/lid; other site 243231005205 ABC transporter signature motif; other site 243231005206 Walker B; other site 243231005207 D-loop; other site 243231005208 H-loop/switch region; other site 243231005209 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 243231005210 putative active site [active] 243231005211 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243231005212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243231005213 active site 243231005214 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 243231005215 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 243231005216 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 243231005217 Walker A/P-loop; other site 243231005218 ATP binding site [chemical binding]; other site 243231005219 Q-loop/lid; other site 243231005220 ABC transporter signature motif; other site 243231005221 Walker B; other site 243231005222 D-loop; other site 243231005223 H-loop/switch region; other site 243231005224 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 243231005225 putative carbohydrate binding site [chemical binding]; other site 243231005226 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 243231005227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231005228 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 243231005229 putative ligand binding site [chemical binding]; other site 243231005230 putative catalytic site [active] 243231005231 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231005232 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 243231005233 Probable Catalytic site; other site 243231005234 conserved nucleotide sequence; similar to other Geobacter species; GSUR0183 243231005235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243231005236 active site 243231005237 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 243231005238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243231005239 active site 243231005240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231005241 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243231005242 hypothetical protein; Provisional; Region: PRK07208 243231005243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243231005244 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 243231005245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231005246 S-adenosylmethionine binding site [chemical binding]; other site 243231005247 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243231005248 putative active site [active] 243231005249 trRNA_3; GSUR0070 243231005250 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 243231005251 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 243231005252 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 243231005253 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243231005254 active site 243231005255 dimer interface [polypeptide binding]; other site 243231005256 motif 1; other site 243231005257 motif 2; other site 243231005258 motif 3; other site 243231005259 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243231005260 anticodon binding site; other site 243231005261 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 243231005262 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 243231005263 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 243231005264 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243231005265 conserved nucleotide sequence; similar to other Geobacter species; GSUR0184 243231005266 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243231005267 23S rRNA binding site [nucleotide binding]; other site 243231005268 L21 binding site [polypeptide binding]; other site 243231005269 L13 binding site [polypeptide binding]; other site 243231005270 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 243231005271 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 243231005272 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243231005273 dimer interface [polypeptide binding]; other site 243231005274 motif 1; other site 243231005275 active site 243231005276 motif 2; other site 243231005277 motif 3; other site 243231005278 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 243231005279 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 243231005280 putative tRNA-binding site [nucleotide binding]; other site 243231005281 B3/4 domain; Region: B3_4; pfam03483 243231005282 tRNA synthetase B5 domain; Region: B5; smart00874 243231005283 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 243231005284 dimer interface [polypeptide binding]; other site 243231005285 motif 1; other site 243231005286 motif 3; other site 243231005287 motif 2; other site 243231005288 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 243231005289 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 243231005290 DNA binding site [nucleotide binding] 243231005291 dimer interface [polypeptide binding]; other site 243231005292 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 243231005293 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 243231005294 DNA binding residues [nucleotide binding] 243231005295 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 243231005296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231005297 S-adenosylmethionine binding site [chemical binding]; other site 243231005298 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243231005299 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 243231005300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243231005301 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243231005302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243231005303 DNA binding residues [nucleotide binding] 243231005304 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231005305 active site 243231005306 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 243231005307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231005308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231005309 substrate binding pocket [chemical binding]; other site 243231005310 membrane-bound complex binding site; other site 243231005311 hinge residues; other site 243231005312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005313 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231005314 putative active site [active] 243231005315 heme pocket [chemical binding]; other site 243231005316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231005317 dimer interface [polypeptide binding]; other site 243231005318 phosphorylation site [posttranslational modification] 243231005319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231005320 ATP binding site [chemical binding]; other site 243231005321 Mg2+ binding site [ion binding]; other site 243231005322 G-X-G motif; other site 243231005323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005324 active site 243231005325 phosphorylation site [posttranslational modification] 243231005326 intermolecular recognition site; other site 243231005327 dimerization interface [polypeptide binding]; other site 243231005328 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 243231005329 ATP phosphoribosyltransferase; Region: HisG; cl15266 243231005330 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 243231005331 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 243231005332 TSCPD domain; Region: TSCPD; pfam12637 243231005333 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 243231005334 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 243231005335 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 243231005336 Part of AAA domain; Region: AAA_19; pfam13245 243231005337 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243231005338 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 243231005339 AAA domain; Region: AAA_30; pfam13604 243231005340 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243231005341 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 243231005342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231005343 Walker A motif; other site 243231005344 ATP binding site [chemical binding]; other site 243231005345 Walker B motif; other site 243231005346 arginine finger; other site 243231005347 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 243231005348 putative active site [active] 243231005349 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 243231005350 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 243231005351 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243231005352 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 243231005353 putative catalytic site [active] 243231005354 putative phosphate binding site [ion binding]; other site 243231005355 active site 243231005356 metal binding site A [ion binding]; metal-binding site 243231005357 DNA binding site [nucleotide binding] 243231005358 putative AP binding site [nucleotide binding]; other site 243231005359 putative metal binding site B [ion binding]; other site 243231005360 conserved nucleotide sequence; similar to other Geobacter species; GSUR0185 243231005361 conserved nucleotide sequence; similar to other Geobacter species; GSUR0186 243231005362 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243231005363 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243231005364 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243231005365 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243231005366 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243231005367 conserved nucleotide sequence; similar to other Geobacter species; GSUR0187 243231005368 Transposase IS200 like; Region: Y1_Tnp; cl00848 243231005369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231005370 non-specific DNA binding site [nucleotide binding]; other site 243231005371 salt bridge; other site 243231005372 sequence-specific DNA binding site [nucleotide binding]; other site 243231005373 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 243231005374 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 243231005375 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 243231005376 TPR repeat; Region: TPR_11; pfam13414 243231005377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005378 binding surface 243231005379 TPR motif; other site 243231005380 TPR repeat; Region: TPR_11; pfam13414 243231005381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005382 binding surface 243231005383 TPR motif; other site 243231005384 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231005385 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231005386 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243231005387 dinuclear metal binding motif [ion binding]; other site 243231005388 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243231005389 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243231005390 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 243231005391 active site 1 [active] 243231005392 dimer interface [polypeptide binding]; other site 243231005393 hexamer interface [polypeptide binding]; other site 243231005394 active site 2 [active] 243231005395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231005396 dimerization interface [polypeptide binding]; other site 243231005397 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243231005398 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 243231005399 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 243231005400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231005401 metal binding site [ion binding]; metal-binding site 243231005402 active site 243231005403 I-site; other site 243231005404 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 243231005405 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005406 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243231005407 putative active site [active] 243231005408 heme pocket [chemical binding]; other site 243231005409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005410 putative active site [active] 243231005411 heme pocket [chemical binding]; other site 243231005412 GAF domain; Region: GAF_2; pfam13185 243231005413 PAS domain S-box; Region: sensory_box; TIGR00229 243231005414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005415 putative active site [active] 243231005416 heme pocket [chemical binding]; other site 243231005417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231005418 dimer interface [polypeptide binding]; other site 243231005419 phosphorylation site [posttranslational modification] 243231005420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231005421 ATP binding site [chemical binding]; other site 243231005422 Mg2+ binding site [ion binding]; other site 243231005423 G-X-G motif; other site 243231005424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005425 active site 243231005426 phosphorylation site [posttranslational modification] 243231005427 intermolecular recognition site; other site 243231005428 dimerization interface [polypeptide binding]; other site 243231005429 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 243231005430 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243231005431 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243231005432 radical SAM modification target peptide, selenobiotic family; Region: selen_ocin; TIGR04081 243231005433 radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340 243231005434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231005435 FeS/SAM binding site; other site 243231005436 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243231005437 Transglycosylase; Region: Transgly; pfam00912 243231005438 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 243231005439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 243231005440 Domain of unknown function DUF77; Region: DUF77; pfam01910 243231005441 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; cl19202 243231005442 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 243231005443 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 243231005444 conserved nucleotide sequence; similar to other Geobacter species; GSUR0071 243231005445 Peptidase family M48; Region: Peptidase_M48; cl12018 243231005446 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 243231005447 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 243231005448 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 243231005449 GrpB protein; Region: GrpB; pfam04229 243231005450 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 243231005451 folate binding site [chemical binding]; other site 243231005452 NADP+ binding site [chemical binding]; other site 243231005453 CAAX protease self-immunity; Region: Abi; pfam02517 243231005454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231005455 S-adenosylmethionine binding site [chemical binding]; other site 243231005456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231005457 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 243231005458 NAD(P) binding site [chemical binding]; other site 243231005459 active site 243231005460 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 243231005461 homodimer interface [polypeptide binding]; other site 243231005462 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 243231005463 Walker A motif; other site 243231005464 ATP binding site [chemical binding]; other site 243231005465 hydroxycobalamin binding site [chemical binding]; other site 243231005466 Walker B motif; other site 243231005467 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 243231005468 B12 binding site [chemical binding]; other site 243231005469 cobalt ligand [ion binding]; other site 243231005470 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 243231005471 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 243231005472 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 243231005473 Walker A; other site 243231005474 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 243231005475 DHH family; Region: DHH; pfam01368 243231005476 FOG: CBS domain [General function prediction only]; Region: COG0517 243231005477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 243231005478 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 243231005479 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243231005480 active site 243231005481 NTP binding site [chemical binding]; other site 243231005482 metal binding triad [ion binding]; metal-binding site 243231005483 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243231005484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 243231005485 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 243231005486 inhibitor-cofactor binding pocket; inhibition site 243231005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231005488 catalytic residue [active] 243231005489 AAA domain; Region: AAA_26; pfam13500 243231005490 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 243231005491 biotin synthase; Region: bioB; TIGR00433 243231005492 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231005493 FeS/SAM binding site; other site 243231005494 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 243231005495 hypothetical protein; Provisional; Region: PRK14641 243231005496 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 243231005497 putative oligomer interface [polypeptide binding]; other site 243231005498 putative RNA binding site [nucleotide binding]; other site 243231005499 NusA N-terminal domain; Region: NusA_N; pfam08529 243231005500 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 243231005501 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 243231005502 RNA binding site [nucleotide binding]; other site 243231005503 homodimer interface [polypeptide binding]; other site 243231005504 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243231005505 G-X-X-G motif; other site 243231005506 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243231005507 G-X-X-G motif; other site 243231005508 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 243231005509 putative RNA binding cleft [nucleotide binding]; other site 243231005510 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 243231005511 translation initiation factor IF-2; Validated; Region: infB; PRK05306 243231005512 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243231005513 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243231005514 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243231005515 G1 box; other site 243231005516 putative GEF interaction site [polypeptide binding]; other site 243231005517 GTP/Mg2+ binding site [chemical binding]; other site 243231005518 Switch I region; other site 243231005519 G2 box; other site 243231005520 G3 box; other site 243231005521 Switch II region; other site 243231005522 G4 box; other site 243231005523 G5 box; other site 243231005524 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243231005525 Translation-initiation factor 2; Region: IF-2; pfam11987 243231005526 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243231005527 ribosome-binding factor A; Provisional; Region: PRK13815 243231005528 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 243231005529 DHH family; Region: DHH; pfam01368 243231005530 Pseudouridine synthase [Translation, ribosomal structure and biogenesis]; Region: TruB; COG0130 243231005531 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 243231005532 RNA binding site [nucleotide binding]; other site 243231005533 active site 243231005534 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243231005535 16S/18S rRNA binding site [nucleotide binding]; other site 243231005536 S13e-L30e interaction site [polypeptide binding]; other site 243231005537 25S rRNA binding site [nucleotide binding]; other site 243231005538 conserved nucleotide sequence; similar to other Geobacter species; GSUR0188 243231005539 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 243231005540 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 243231005541 RNase E interface [polypeptide binding]; other site 243231005542 trimer interface [polypeptide binding]; other site 243231005543 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 243231005544 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 243231005545 RNase E interface [polypeptide binding]; other site 243231005546 trimer interface [polypeptide binding]; other site 243231005547 active site 243231005548 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 243231005549 putative nucleic acid binding region [nucleotide binding]; other site 243231005550 G-X-X-G motif; other site 243231005551 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 243231005552 RNA binding site [nucleotide binding]; other site 243231005553 domain interface; other site 243231005554 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243231005555 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243231005556 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243231005557 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 243231005558 trimer interface [polypeptide binding]; other site 243231005559 active site 243231005560 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 243231005561 conserved nucleotide sequence; similar to other Geobacter species; GSUR0189 243231005562 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 243231005563 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 243231005564 putative phosphate acyltransferase; Provisional; Region: PRK05331 243231005565 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 243231005566 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 243231005567 dimer interface [polypeptide binding]; other site 243231005568 active site 243231005569 CoA binding pocket [chemical binding]; other site 243231005570 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 243231005571 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 243231005572 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 243231005573 NAD(P) binding site [chemical binding]; other site 243231005574 homotetramer interface [polypeptide binding]; other site 243231005575 homodimer interface [polypeptide binding]; other site 243231005576 active site 243231005577 acyl carrier protein; Provisional; Region: acpP; PRK00982 243231005578 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 243231005579 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 243231005580 dimer interface [polypeptide binding]; other site 243231005581 active site 243231005582 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 243231005583 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243231005584 dimer interface [polypeptide binding]; other site 243231005585 active site 243231005586 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243231005587 folate binding site [chemical binding]; other site 243231005588 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 243231005589 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243231005590 Outer membrane efflux protein; Region: OEP; pfam02321 243231005591 Outer membrane efflux protein; Region: OEP; pfam02321 243231005592 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243231005593 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231005594 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231005595 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243231005596 MMPL family; Region: MMPL; cl14618 243231005597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243231005598 catalytic core [active] 243231005599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243231005600 minor groove reading motif; other site 243231005601 helix-hairpin-helix signature motif; other site 243231005602 substrate binding pocket [chemical binding]; other site 243231005603 active site 243231005604 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 243231005605 CoA binding domain; Region: CoA_binding_2; pfam13380 243231005606 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 243231005607 DNA polymerase IV; Reviewed; Region: PRK03103 243231005608 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243231005609 active site 243231005610 DNA binding site [nucleotide binding] 243231005611 LexA repressor; Validated; Region: PRK00215 243231005612 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 243231005613 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243231005614 Catalytic site [active] 243231005615 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 243231005616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005617 active site 243231005618 phosphorylation site [posttranslational modification] 243231005619 intermolecular recognition site; other site 243231005620 dimerization interface [polypeptide binding]; other site 243231005621 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 243231005622 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243231005623 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243231005624 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231005625 Cysteine-rich domain; Region: CCG; pfam02754 243231005626 Cysteine-rich domain; Region: CCG; pfam02754 243231005627 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 243231005628 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 243231005629 FAD binding domain; Region: FAD_binding_4; pfam01565 243231005630 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 243231005631 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 243231005632 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243231005633 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231005634 Cysteine-rich domain; Region: CCG; pfam02754 243231005635 Cysteine-rich domain; Region: CCG; pfam02754 243231005636 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243231005637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243231005638 DNA-binding site [nucleotide binding]; DNA binding site 243231005639 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 243231005640 Preprotein translocase SecG subunit; Region: SecG; pfam03840 243231005641 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243231005642 substrate binding site [chemical binding]; other site 243231005643 dimer interface [polypeptide binding]; other site 243231005644 catalytic triad [active] 243231005645 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 243231005646 substrate binding site [chemical binding]; other site 243231005647 hinge regions; other site 243231005648 ADP binding site [chemical binding]; other site 243231005649 catalytic site [active] 243231005650 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 243231005651 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 243231005652 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243231005653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 243231005654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231005655 dimerization interface [polypeptide binding]; other site 243231005656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005657 putative active site [active] 243231005658 heme pocket [chemical binding]; other site 243231005659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231005660 dimer interface [polypeptide binding]; other site 243231005661 phosphorylation site [posttranslational modification] 243231005662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231005663 ATP binding site [chemical binding]; other site 243231005664 Mg2+ binding site [ion binding]; other site 243231005665 G-X-G motif; other site 243231005666 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 243231005667 adenylosuccinate lyase; Provisional; Region: PRK07492 243231005668 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 243231005669 tetramer interface [polypeptide binding]; other site 243231005670 active site 243231005671 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243231005672 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 243231005673 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 243231005674 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 243231005675 dimerization interface [polypeptide binding]; other site 243231005676 ATP binding site [chemical binding]; other site 243231005677 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 243231005678 dimerization interface [polypeptide binding]; other site 243231005679 ATP binding site [chemical binding]; other site 243231005680 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 243231005681 conserved cys residue [active] 243231005682 amidophosphoribosyltransferase; Provisional; Region: PRK09123 243231005683 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 243231005684 active site 243231005685 tetramer interface [polypeptide binding]; other site 243231005686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231005687 active site 243231005688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243231005689 active site 243231005690 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 243231005691 Predicted transcriptional regulator [Transcription]; Region: COG1959 243231005692 Rrf2 family protein; Region: rrf2_super; TIGR00738 243231005693 conserved palindrome; GSUR0190 243231005694 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 243231005695 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 243231005696 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 243231005697 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231005698 diiron binding motif [ion binding]; other site 243231005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005700 active site 243231005701 phosphorylation site [posttranslational modification] 243231005702 intermolecular recognition site; other site 243231005703 dimerization interface [polypeptide binding]; other site 243231005704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231005705 metal binding site [ion binding]; metal-binding site 243231005706 active site 243231005707 I-site; other site 243231005708 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 243231005709 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231005710 ABC transporter; Region: ABC_tran_2; pfam12848 243231005711 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231005712 Cytochrome c7; Region: Cytochrome_C7; cl19206 243231005713 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231005714 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 243231005715 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 243231005716 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 243231005717 intrachain domain interface; other site 243231005718 interchain domain interface [polypeptide binding]; other site 243231005719 heme bH binding site [chemical binding]; other site 243231005720 Qi binding site; other site 243231005721 heme bL binding site [chemical binding]; other site 243231005722 Qo binding site; other site 243231005723 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 243231005724 interchain domain interface [polypeptide binding]; other site 243231005725 intrachain domain interface; other site 243231005726 Qi binding site; other site 243231005727 Qo binding site; other site 243231005728 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 243231005729 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 243231005730 iron-sulfur cluster [ion binding]; other site 243231005731 [2Fe-2S] cluster binding site [ion binding]; other site 243231005732 conserved nucleotide sequence; similar to other Geobacter species; GSUR1003 243231005733 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 243231005734 AMP binding site [chemical binding]; other site 243231005735 metal binding site [ion binding]; metal-binding site 243231005736 active site 243231005737 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231005738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005739 active site 243231005740 phosphorylation site [posttranslational modification] 243231005741 intermolecular recognition site; other site 243231005742 dimerization interface [polypeptide binding]; other site 243231005743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231005744 Walker A motif; other site 243231005745 ATP binding site [chemical binding]; other site 243231005746 Walker B motif; other site 243231005747 arginine finger; other site 243231005748 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231005749 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243231005750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005751 active site 243231005752 phosphorylation site [posttranslational modification] 243231005753 intermolecular recognition site; other site 243231005754 dimerization interface [polypeptide binding]; other site 243231005755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231005756 Zn2+ binding site [ion binding]; other site 243231005757 Mg2+ binding site [ion binding]; other site 243231005758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005759 active site 243231005760 phosphorylation site [posttranslational modification] 243231005761 intermolecular recognition site; other site 243231005762 dimerization interface [polypeptide binding]; other site 243231005763 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 243231005764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005765 putative active site [active] 243231005766 heme pocket [chemical binding]; other site 243231005767 GAF domain; Region: GAF_2; pfam13185 243231005768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231005769 dimer interface [polypeptide binding]; other site 243231005770 phosphorylation site [posttranslational modification] 243231005771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231005772 ATP binding site [chemical binding]; other site 243231005773 Mg2+ binding site [ion binding]; other site 243231005774 G-X-G motif; other site 243231005775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005776 active site 243231005777 phosphorylation site [posttranslational modification] 243231005778 intermolecular recognition site; other site 243231005779 dimerization interface [polypeptide binding]; other site 243231005780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005781 active site 243231005782 phosphorylation site [posttranslational modification] 243231005783 intermolecular recognition site; other site 243231005784 dimerization interface [polypeptide binding]; other site 243231005785 PAS domain S-box; Region: sensory_box; TIGR00229 243231005786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231005787 putative active site [active] 243231005788 heme pocket [chemical binding]; other site 243231005789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231005790 metal binding site [ion binding]; metal-binding site 243231005791 active site 243231005792 I-site; other site 243231005793 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 243231005794 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 243231005795 Competence protein; Region: Competence; pfam03772 243231005796 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231005797 response regulator PleD; Reviewed; Region: pleD; PRK09581 243231005798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005799 active site 243231005800 phosphorylation site [posttranslational modification] 243231005801 intermolecular recognition site; other site 243231005802 dimerization interface [polypeptide binding]; other site 243231005803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231005804 metal binding site [ion binding]; metal-binding site 243231005805 active site 243231005806 I-site; other site 243231005807 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 243231005808 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243231005809 dimer interface [polypeptide binding]; other site 243231005810 motif 1; other site 243231005811 active site 243231005812 motif 2; other site 243231005813 motif 3; other site 243231005814 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 243231005815 anticodon binding site; other site 243231005816 conserved nucleotide sequence; similar to other Geobacter species; GSUR0191 243231005817 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 243231005818 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 243231005819 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 243231005820 substrate binding site [chemical binding]; other site 243231005821 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 243231005822 substrate binding site [chemical binding]; other site 243231005823 ligand binding site [chemical binding]; other site 243231005824 conserved nucleotide sequence; similar to other Geobacter species; GSUR0192 243231005825 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 243231005826 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 243231005827 Domain of unknown function (DUF309); Region: DUF309; pfam03745 243231005828 Rhomboid family; Region: Rhomboid; cl11446 243231005829 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231005830 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231005831 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 243231005832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231005833 active site 243231005834 phosphorylation site [posttranslational modification] 243231005835 intermolecular recognition site; other site 243231005836 dimerization interface [polypeptide binding]; other site 243231005837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231005838 metal binding site [ion binding]; metal-binding site 243231005839 active site 243231005840 I-site; other site 243231005841 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 243231005842 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 243231005843 putative ligand binding site [chemical binding]; other site 243231005844 putative NAD binding site [chemical binding]; other site 243231005845 catalytic site [active] 243231005846 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 243231005847 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 243231005848 acyl-activating enzyme (AAE) consensus motif; other site 243231005849 putative AMP binding site [chemical binding]; other site 243231005850 putative active site [active] 243231005851 putative CoA binding site [chemical binding]; other site 243231005852 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 243231005853 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243231005854 putative acyl-acceptor binding pocket; other site 243231005855 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243231005856 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243231005857 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243231005858 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243231005859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231005860 motif II; other site 243231005861 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243231005862 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 243231005863 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231005864 AAA domain; Region: AAA_26; pfam13500 243231005865 DRTGG domain; Region: DRTGG; pfam07085 243231005866 Protein of unknown function (DUF327); Region: DUF327; pfam03885 243231005867 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 243231005868 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 243231005869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231005870 Zn2+ binding site [ion binding]; other site 243231005871 Mg2+ binding site [ion binding]; other site 243231005872 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 243231005873 catalytic motif [active] 243231005874 Zn binding site [ion binding]; other site 243231005875 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 243231005876 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 243231005877 ATP cone domain; Region: ATP-cone; pfam03477 243231005878 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 243231005879 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 243231005880 catalytic motif [active] 243231005881 Zn binding site [ion binding]; other site 243231005882 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 243231005883 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 243231005884 Lumazine binding domain; Region: Lum_binding; pfam00677 243231005885 Lumazine binding domain; Region: Lum_binding; pfam00677 243231005886 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 243231005887 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 243231005888 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 243231005889 dimerization interface [polypeptide binding]; other site 243231005890 active site 243231005891 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 243231005892 homopentamer interface [polypeptide binding]; other site 243231005893 active site 243231005894 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 243231005895 putative RNA binding site [nucleotide binding]; other site 243231005896 homoserine dehydrogenase; Provisional; Region: PRK06349 243231005897 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 243231005898 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 243231005899 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 243231005900 GMP/IMP nucleotidase; Provisional; Region: PRK14988 243231005901 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 243231005902 threonine synthase; Validated; Region: PRK09225 243231005903 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 243231005904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231005905 catalytic residue [active] 243231005906 MoxR-like ATPases [General function prediction only]; Region: COG0714 243231005907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231005908 Walker A motif; other site 243231005909 ATP binding site [chemical binding]; other site 243231005910 Walker B motif; other site 243231005911 arginine finger; other site 243231005912 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 243231005913 Protein of unknown function DUF58; Region: DUF58; pfam01882 243231005914 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 243231005915 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243231005916 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243231005917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005918 TPR motif; other site 243231005919 binding surface 243231005920 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243231005921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005922 TPR motif; other site 243231005923 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243231005924 binding surface 243231005925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231005926 binding surface 243231005927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243231005928 TPR motif; other site 243231005929 TolA protein; Region: tolA_full; TIGR02794 243231005930 TonB C terminal; Region: TonB_2; pfam13103 243231005931 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 243231005932 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243231005933 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 243231005934 putative NAD(P) binding site [chemical binding]; other site 243231005935 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 243231005936 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 243231005937 nucleotide binding site/active site [active] 243231005938 HIT family signature motif; other site 243231005939 catalytic residue [active] 243231005940 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243231005941 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243231005942 nucleotide binding site [chemical binding]; other site 243231005943 phosphofructokinase; Region: PFK_mixed; TIGR02483 243231005944 active site 243231005945 ADP/pyrophosphate binding site [chemical binding]; other site 243231005946 dimerization interface [polypeptide binding]; other site 243231005947 allosteric effector site; other site 243231005948 fructose-1,6-bisphosphate binding site; other site 243231005949 Protein of unknown function N-terminal domain (DUF2450); Region: DUF2450; cl19949 243231005950 GAF domain; Region: GAF; pfam01590 243231005951 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231005952 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231005953 dimer interface [polypeptide binding]; other site 243231005954 putative CheW interface [polypeptide binding]; other site 243231005955 conserved nucleotide sequence; similar to other Geobacter species; GSUR0193 243231005956 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 243231005957 oligomerization interface [polypeptide binding]; other site 243231005958 active site 243231005959 metal binding site [ion binding]; metal-binding site 243231005960 Pantoate-beta-alanine ligase; Region: PanC; cd00560 243231005961 active site 243231005962 ATP-binding site [chemical binding]; other site 243231005963 pantoate-binding site; other site 243231005964 HXXH motif; other site 243231005965 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 243231005966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231005967 catalytic residue [active] 243231005968 chlorohydrolase; Provisional; Region: PRK08418 243231005969 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_D; cd01312 243231005970 active site 243231005971 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 243231005972 SmpB-tmRNA interface; other site 243231005973 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 243231005974 Int/Topo IB signature motif; other site 243231005975 multiple promoter invertase; Provisional; Region: mpi; PRK13413 243231005976 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 243231005977 catalytic residues [active] 243231005978 catalytic nucleophile [active] 243231005979 Presynaptic Site I dimer interface [polypeptide binding]; other site 243231005980 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 243231005981 Synaptic Flat tetramer interface [polypeptide binding]; other site 243231005982 Synaptic Site I dimer interface [polypeptide binding]; other site 243231005983 DNA binding site [nucleotide binding] 243231005984 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 243231005985 DNA-binding interface [nucleotide binding]; DNA binding site 243231005986 AntA/AntB antirepressor; Region: AntA; pfam08346 243231005987 conserved nucleotide sequence; similar to other Geobacter species; GSUR0194 243231005988 conserved nucleotide sequence; similar to other Geobacter species; GSUR0195 243231005989 conserved nucleotide sequence; similar to other Geobacter species; GSUR0196 243231005990 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243231005991 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243231005992 Active Sites [active] 243231005993 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 243231005994 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 243231005995 Active Sites [active] 243231005996 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 243231005997 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 243231005998 CysD dimerization site [polypeptide binding]; other site 243231005999 G1 box; other site 243231006000 putative GEF interaction site [polypeptide binding]; other site 243231006001 GTP/Mg2+ binding site [chemical binding]; other site 243231006002 Switch I region; other site 243231006003 G2 box; other site 243231006004 G3 box; other site 243231006005 Switch II region; other site 243231006006 G4 box; other site 243231006007 G5 box; other site 243231006008 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 243231006009 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 243231006010 ParG; Region: ParG; pfam09274 243231006011 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 243231006012 active site 243231006013 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 243231006014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231006015 FeS/SAM binding site; other site 243231006016 Creatinine amidohydrolase; Region: Creatininase; pfam02633 243231006017 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243231006018 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243231006019 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 243231006020 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 243231006021 active site 243231006022 metal binding site [ion binding]; metal-binding site 243231006023 DNA binding site [nucleotide binding] 243231006024 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 243231006025 AAA domain; Region: AAA_23; pfam13476 243231006026 Walker A/P-loop; other site 243231006027 ATP binding site [chemical binding]; other site 243231006028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 243231006029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231006030 ABC transporter signature motif; other site 243231006031 Walker B; other site 243231006032 D-loop; other site 243231006033 H-loop/switch region; other site 243231006034 conserved nucleotide sequence; similar to other Geobacter species; GSUR0197 243231006035 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 243231006036 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 243231006037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231006038 FeS/SAM binding site; other site 243231006039 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 243231006040 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243231006041 acyl-activating enzyme (AAE) consensus motif; other site 243231006042 AMP binding site [chemical binding]; other site 243231006043 active site 243231006044 CoA binding site [chemical binding]; other site 243231006045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243231006046 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243231006047 Walker A/P-loop; other site 243231006048 ATP binding site [chemical binding]; other site 243231006049 Q-loop/lid; other site 243231006050 ABC transporter signature motif; other site 243231006051 Walker B; other site 243231006052 D-loop; other site 243231006053 H-loop/switch region; other site 243231006054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243231006055 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243231006056 Walker A/P-loop; other site 243231006057 ATP binding site [chemical binding]; other site 243231006058 Q-loop/lid; other site 243231006059 ABC transporter signature motif; other site 243231006060 Walker B; other site 243231006061 D-loop; other site 243231006062 H-loop/switch region; other site 243231006063 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243231006064 TM-ABC transporter signature motif; other site 243231006065 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243231006066 TM-ABC transporter signature motif; other site 243231006067 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 243231006068 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 243231006069 putative ligand binding site [chemical binding]; other site 243231006070 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 243231006071 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 243231006072 putative ligand binding site [chemical binding]; other site 243231006073 ACT domain-containing protein [General function prediction only]; Region: COG4747 243231006074 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 243231006075 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 243231006076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243231006077 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 243231006078 acyl-activating enzyme (AAE) consensus motif; other site 243231006079 AMP binding site [chemical binding]; other site 243231006080 active site 243231006081 CoA binding site [chemical binding]; other site 243231006082 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 243231006083 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 243231006084 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243231006085 dimer interface [polypeptide binding]; other site 243231006086 PYR/PP interface [polypeptide binding]; other site 243231006087 TPP binding site [chemical binding]; other site 243231006088 substrate binding site [chemical binding]; other site 243231006089 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 243231006090 TPP-binding site; other site 243231006091 conserved nucleotide sequence; similar to other Geobacter species; GSUR0198 243231006092 Cytochrome c; Region: Cytochrom_C; cl11414 243231006093 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 243231006094 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 243231006095 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243231006096 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 243231006097 PhoU domain; Region: PhoU; pfam01895 243231006098 PhoU domain; Region: PhoU; pfam01895 243231006099 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 243231006100 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231006101 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231006102 ligand binding site [chemical binding]; other site 243231006103 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 243231006104 dimer interface [polypeptide binding]; other site 243231006105 DNA binding site [nucleotide binding] 243231006106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006107 TPR motif; other site 243231006108 binding surface 243231006109 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 243231006110 TRAM domain; Region: TRAM; pfam01938 243231006111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231006112 S-adenosylmethionine binding site [chemical binding]; other site 243231006113 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243231006114 rRNA binding site [nucleotide binding]; other site 243231006115 predicted 30S ribosome binding site; other site 243231006116 elongation factor P; Validated; Region: PRK00529 243231006117 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243231006118 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243231006119 RNA binding site [nucleotide binding]; other site 243231006120 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243231006121 RNA binding site [nucleotide binding]; other site 243231006122 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243231006123 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 243231006124 motif 1; other site 243231006125 dimer interface [polypeptide binding]; other site 243231006126 active site 243231006127 motif 2; other site 243231006128 motif 3; other site 243231006129 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 243231006130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231006131 FeS/SAM binding site; other site 243231006132 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 243231006133 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 243231006134 heterodimer interface [polypeptide binding]; other site 243231006135 active site 243231006136 FMN binding site [chemical binding]; other site 243231006137 homodimer interface [polypeptide binding]; other site 243231006138 substrate binding site [chemical binding]; other site 243231006139 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 243231006140 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 243231006141 FAD binding pocket [chemical binding]; other site 243231006142 FAD binding motif [chemical binding]; other site 243231006143 phosphate binding motif [ion binding]; other site 243231006144 beta-alpha-beta structure motif; other site 243231006145 NAD binding pocket [chemical binding]; other site 243231006146 Iron coordination center [ion binding]; other site 243231006147 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 243231006148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243231006149 Coenzyme A binding pocket [chemical binding]; other site 243231006150 conserved nucleotide sequence; similar to other Geobacter species; GSUR0199 243231006151 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 243231006152 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 243231006153 dimerization interface [polypeptide binding]; other site 243231006154 putative ATP binding site [chemical binding]; other site 243231006155 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 243231006156 active site 243231006157 substrate binding site [chemical binding]; other site 243231006158 cosubstrate binding site; other site 243231006159 catalytic site [active] 243231006160 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231006161 heme-binding residues [chemical binding]; other site 243231006162 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243231006163 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243231006164 Cytochrome c; Region: Cytochrom_C; pfam00034 243231006165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006166 TPR repeat; Region: TPR_11; pfam13414 243231006167 binding surface 243231006168 TPR motif; other site 243231006169 TPR repeat; Region: TPR_11; pfam13414 243231006170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006171 TPR motif; other site 243231006172 binding surface 243231006173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243231006174 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 243231006175 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243231006176 HSP70 interaction site [polypeptide binding]; other site 243231006177 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 243231006178 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 243231006179 TPP-binding site; other site 243231006180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243231006181 PYR/PP interface [polypeptide binding]; other site 243231006182 dimer interface [polypeptide binding]; other site 243231006183 TPP binding site [chemical binding]; other site 243231006184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231006185 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 243231006186 substrate binding pocket [chemical binding]; other site 243231006187 chain length determination region; other site 243231006188 active site lid residues [active] 243231006189 substrate-Mg2+ binding site; other site 243231006190 catalytic residues [active] 243231006191 aspartate-rich region 1; other site 243231006192 aspartate-rich region 2; other site 243231006193 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14066 243231006194 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 243231006195 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 243231006196 generic binding surface II; other site 243231006197 generic binding surface I; other site 243231006198 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243231006199 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243231006200 P-loop; other site 243231006201 Magnesium ion binding site [ion binding]; other site 243231006202 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 243231006203 NodB motif; other site 243231006204 putative active site [active] 243231006205 putative catalytic site [active] 243231006206 Zn binding site [ion binding]; other site 243231006207 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 243231006208 dockerin binding interface [polypeptide binding]; other site 243231006209 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 243231006210 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 243231006211 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 243231006212 C-terminal peptidase (prc); Region: prc; TIGR00225 243231006213 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 243231006214 protein binding site [polypeptide binding]; other site 243231006215 Catalytic dyad [active] 243231006216 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 243231006217 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl19018 243231006218 Peptidase family M23; Region: Peptidase_M23; pfam01551 243231006219 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 243231006220 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 243231006221 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 243231006222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231006223 Walker A/P-loop; other site 243231006224 ATP binding site [chemical binding]; other site 243231006225 Q-loop/lid; other site 243231006226 ABC transporter signature motif; other site 243231006227 Walker B; other site 243231006228 D-loop; other site 243231006229 H-loop/switch region; other site 243231006230 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243231006231 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 243231006232 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243231006233 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243231006234 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 243231006235 TPR repeat; Region: TPR_11; pfam13414 243231006236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006237 binding surface 243231006238 TPR motif; other site 243231006239 TPR repeat; Region: TPR_11; pfam13414 243231006240 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 243231006241 Secretin and TonB N terminus short domain; Region: STN; smart00965 243231006242 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243231006243 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243231006244 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 243231006245 dockerin binding interface [polypeptide binding]; other site 243231006246 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 243231006247 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 243231006248 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 243231006249 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231006250 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 243231006251 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243231006252 Walker A motif; other site 243231006253 ATP binding site [chemical binding]; other site 243231006254 Walker B motif; other site 243231006255 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 243231006256 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243231006257 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 243231006258 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231006259 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243231006260 NHL repeat; Region: NHL; pfam01436 243231006261 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231006262 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 243231006263 Ligand binding site; other site 243231006264 Putative Catalytic site; other site 243231006265 DXD motif; other site 243231006266 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243231006267 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 243231006268 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243231006269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231006270 Walker A motif; other site 243231006271 ATP binding site [chemical binding]; other site 243231006272 Walker B motif; other site 243231006273 arginine finger; other site 243231006274 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243231006275 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 243231006276 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 243231006277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231006278 Walker A motif; other site 243231006279 ATP binding site [chemical binding]; other site 243231006280 Walker B motif; other site 243231006281 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 243231006282 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 243231006283 oligomer interface [polypeptide binding]; other site 243231006284 active site residues [active] 243231006285 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 243231006286 trigger factor; Region: tig; TIGR00115 243231006287 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243231006288 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243231006289 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 243231006290 active site 243231006291 dimerization interface [polypeptide binding]; other site 243231006292 ribonuclease PH; Reviewed; Region: rph; PRK00173 243231006293 Ribonuclease PH; Region: RNase_PH_bact; cd11362 243231006294 hexamer interface [polypeptide binding]; other site 243231006295 active site 243231006296 DHH family; Region: DHH; pfam01368 243231006297 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 243231006298 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 243231006299 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 243231006300 active site 243231006301 catalytic residues [active] 243231006302 metal binding site [ion binding]; metal-binding site 243231006303 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243231006304 aspartate kinase; Reviewed; Region: PRK06635 243231006305 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 243231006306 putative nucleotide binding site [chemical binding]; other site 243231006307 putative catalytic residues [active] 243231006308 putative Mg ion binding site [ion binding]; other site 243231006309 putative aspartate binding site [chemical binding]; other site 243231006310 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 243231006311 putative allosteric regulatory site; other site 243231006312 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 243231006313 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 243231006314 FOG: CBS domain [General function prediction only]; Region: COG0517 243231006315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243231006316 Uncharacterized conserved protein [Function unknown]; Region: COG0062 243231006317 putative carbohydrate kinase; Provisional; Region: PRK10565 243231006318 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 243231006319 putative substrate binding site [chemical binding]; other site 243231006320 putative ATP binding site [chemical binding]; other site 243231006321 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14656 243231006322 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 243231006323 active site 243231006324 hydrophilic channel; other site 243231006325 dimerization interface [polypeptide binding]; other site 243231006326 catalytic residues [active] 243231006327 active site lid [active] 243231006328 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 243231006329 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 243231006330 active site 243231006331 substrate binding site [chemical binding]; other site 243231006332 metal binding site [ion binding]; metal-binding site 243231006333 Uncharacterized conserved protein [Function unknown]; Region: COG1624 243231006334 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 243231006335 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 243231006336 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 243231006337 substrate binding pocket [chemical binding]; other site 243231006338 dimer interface [polypeptide binding]; other site 243231006339 inhibitor binding site; inhibition site 243231006340 FtsH Extracellular; Region: FtsH_ext; pfam06480 243231006341 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243231006342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231006343 Walker A motif; other site 243231006344 ATP binding site [chemical binding]; other site 243231006345 Walker B motif; other site 243231006346 arginine finger; other site 243231006347 Peptidase family M41; Region: Peptidase_M41; pfam01434 243231006348 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 243231006349 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243231006350 Ligand Binding Site [chemical binding]; other site 243231006351 TilS substrate C-terminal domain; Region: TilS_C; smart00977 243231006352 Sporulation related domain; Region: SPOR; pfam05036 243231006353 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 243231006354 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 243231006355 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 243231006356 active site 243231006357 HIGH motif; other site 243231006358 KMSK motif region; other site 243231006359 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 243231006360 tRNA binding surface [nucleotide binding]; other site 243231006361 anticodon binding site; other site 243231006362 Septum formation initiator; Region: DivIC; pfam04977 243231006363 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 243231006364 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243231006365 NAD binding site [chemical binding]; other site 243231006366 putative substrate binding site 2 [chemical binding]; other site 243231006367 putative substrate binding site 1 [chemical binding]; other site 243231006368 active site 243231006369 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 243231006370 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 243231006371 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243231006372 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243231006373 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 243231006374 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 243231006375 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 243231006376 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 243231006377 active site 243231006378 Int/Topo IB signature motif; other site 243231006379 PII uridylyl-transferase; Provisional; Region: PRK05092 243231006380 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243231006381 metal binding triad; other site 243231006382 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243231006383 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231006384 Zn2+ binding site [ion binding]; other site 243231006385 Mg2+ binding site [ion binding]; other site 243231006386 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 243231006387 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 243231006388 AMIN domain; Region: AMIN; pfam11741 243231006389 AMIN domain; Region: AMIN; pfam11741 243231006390 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 243231006391 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 243231006392 active site 243231006393 metal binding site [ion binding]; metal-binding site 243231006394 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 243231006395 MutS domain I; Region: MutS_I; pfam01624 243231006396 MutS domain II; Region: MutS_II; pfam05188 243231006397 MutS domain III; Region: MutS_III; pfam05192 243231006398 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 243231006399 Walker A/P-loop; other site 243231006400 ATP binding site [chemical binding]; other site 243231006401 Q-loop/lid; other site 243231006402 ABC transporter signature motif; other site 243231006403 Walker B; other site 243231006404 D-loop; other site 243231006405 H-loop/switch region; other site 243231006406 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243231006407 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243231006408 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243231006409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243231006410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243231006411 catalytic residue [active] 243231006412 conserved nucleotide sequence; similar to other Geobacter species; GSUR0200 243231006413 L-aspartate oxidase; Provisional; Region: PRK09077 243231006414 L-aspartate oxidase; Provisional; Region: PRK06175 243231006415 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 243231006416 Chorismate mutase type II; Region: CM_2; pfam01817 243231006417 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 243231006418 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 243231006419 putative ligand binding pocket/active site [active] 243231006420 putative metal binding site [ion binding]; other site 243231006421 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 243231006422 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 243231006423 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 243231006424 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243231006425 active site 243231006426 HIGH motif; other site 243231006427 dimer interface [polypeptide binding]; other site 243231006428 KMSKS motif; other site 243231006429 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 243231006430 Peptidase family M50; Region: Peptidase_M50; pfam02163 243231006431 active site 243231006432 putative substrate binding region [chemical binding]; other site 243231006433 conserved nucleotide sequence; similar to other Geobacter species; GSUR0201 243231006434 glutamine synthetase, type I; Region: GlnA; TIGR00653 243231006435 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 243231006436 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 243231006437 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243231006438 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243231006439 Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; Region: Endostatin-like; cl00181 243231006440 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 243231006441 Peptidase family M23; Region: Peptidase_M23; pfam01551 243231006442 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 243231006443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231006444 ATP binding site [chemical binding]; other site 243231006445 putative Mg++ binding site [ion binding]; other site 243231006446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231006447 nucleotide binding region [chemical binding]; other site 243231006448 ATP-binding site [chemical binding]; other site 243231006449 Helicase associated domain (HA2); Region: HA2; pfam04408 243231006450 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 243231006451 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243231006452 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243231006453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231006454 motif II; other site 243231006455 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 243231006456 active site 243231006457 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243231006458 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231006459 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243231006460 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 243231006461 SLBB domain; Region: SLBB; pfam10531 243231006462 SLBB domain; Region: SLBB; pfam10531 243231006463 SLBB domain; Region: SLBB; pfam10531 243231006464 SLBB domain; Region: SLBB; pfam10531 243231006465 SLBB domain; Region: SLBB; pfam10531 243231006466 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 243231006467 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 243231006468 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231006469 Beta-Casp domain; Region: Beta-Casp; smart01027 243231006470 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 243231006471 IPT/TIG domain; Region: TIG; pfam01833 243231006472 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 243231006473 Transposase; Region: HTH_Tnp_1; cl17663 243231006474 putative transposase OrfB; Reviewed; Region: PHA02517 243231006475 HTH-like domain; Region: HTH_21; pfam13276 243231006476 Integrase core domain; Region: rve; pfam00665 243231006477 Integrase core domain; Region: rve_3; cl15866 243231006478 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 243231006479 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 243231006480 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 243231006481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231006482 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 243231006483 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 243231006484 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 243231006485 trimer interface [polypeptide binding]; other site 243231006486 active site 243231006487 substrate binding site [chemical binding]; other site 243231006488 CoA binding site [chemical binding]; other site 243231006489 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243231006490 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 243231006491 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 243231006492 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243231006493 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 243231006494 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 243231006495 Chain length determinant protein; Region: Wzz; pfam02706 243231006496 Sec1 family; Region: Sec1; cl15415 243231006497 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 243231006498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243231006499 IPT/TIG domain; Region: TIG; pfam01833 243231006500 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243231006501 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 243231006502 conserved nucleotide sequence; similar to other Geobacter species; GSUR0202 243231006503 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 243231006504 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 243231006505 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 243231006506 TPP-binding site [chemical binding]; other site 243231006507 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 243231006508 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243231006509 dimer interface [polypeptide binding]; other site 243231006510 PYR/PP interface [polypeptide binding]; other site 243231006511 TPP binding site [chemical binding]; other site 243231006512 substrate binding site [chemical binding]; other site 243231006513 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231006514 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231006515 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 243231006516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231006517 S-adenosylmethionine binding site [chemical binding]; other site 243231006518 UGMP family protein; Validated; Region: PRK09604 243231006519 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 243231006520 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 243231006521 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 243231006522 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 243231006523 putative active site [active] 243231006524 PhoH-like protein; Region: PhoH; pfam02562 243231006525 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 243231006526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231006527 catalytic residue [active] 243231006528 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 243231006529 GAF domain; Region: GAF_2; pfam13185 243231006530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231006531 metal binding site [ion binding]; metal-binding site 243231006532 active site 243231006533 I-site; other site 243231006534 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 243231006535 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 243231006536 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 243231006537 active site 243231006538 dimer interface [polypeptide binding]; other site 243231006539 effector binding site; other site 243231006540 TSCPD domain; Region: TSCPD; pfam12637 243231006541 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 243231006542 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 243231006543 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 243231006544 active site 243231006545 Zn binding site [ion binding]; other site 243231006546 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 243231006547 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 243231006548 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 243231006549 homotetramer interface [polypeptide binding]; other site 243231006550 ligand binding site [chemical binding]; other site 243231006551 catalytic site [active] 243231006552 NAD binding site [chemical binding]; other site 243231006553 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 243231006554 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 243231006555 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 243231006556 FMN binding site [chemical binding]; other site 243231006557 substrate binding site [chemical binding]; other site 243231006558 putative catalytic residue [active] 243231006559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231006560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231006561 dimer interface [polypeptide binding]; other site 243231006562 phosphorylation site [posttranslational modification] 243231006563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231006564 ATP binding site [chemical binding]; other site 243231006565 Mg2+ binding site [ion binding]; other site 243231006566 G-X-G motif; other site 243231006567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231006568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231006569 active site 243231006570 phosphorylation site [posttranslational modification] 243231006571 intermolecular recognition site; other site 243231006572 dimerization interface [polypeptide binding]; other site 243231006573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231006574 DNA binding site [nucleotide binding] 243231006575 conserved palindrome; GSUR0203 243231006576 S-adenosylmethionine synthetase; Validated; Region: PRK05250 243231006577 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243231006578 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243231006579 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243231006580 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 243231006581 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 243231006582 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243231006583 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243231006584 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 243231006585 dimerization domain swap beta strand [polypeptide binding]; other site 243231006586 regulatory protein interface [polypeptide binding]; other site 243231006587 active site 243231006588 regulatory phosphorylation site [posttranslational modification]; other site 243231006589 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 243231006590 active pocket/dimerization site; other site 243231006591 active site 243231006592 phosphorylation site [posttranslational modification] 243231006593 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 243231006594 AAA domain; Region: AAA_33; pfam13671 243231006595 HPr kinase/phosphorylase; Provisional; Region: PRK05428 243231006596 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 243231006597 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 243231006598 Hpr binding site; other site 243231006599 active site 243231006600 homohexamer subunit interaction site [polypeptide binding]; other site 243231006601 palindrome; GSUR0204 243231006602 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 243231006603 30S subunit binding site; other site 243231006604 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 243231006605 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 243231006606 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 243231006607 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 243231006608 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 243231006609 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 243231006610 Walker A/P-loop; other site 243231006611 ATP binding site [chemical binding]; other site 243231006612 Q-loop/lid; other site 243231006613 ABC transporter signature motif; other site 243231006614 Walker B; other site 243231006615 D-loop; other site 243231006616 H-loop/switch region; other site 243231006617 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 243231006618 OstA-like protein; Region: OstA; pfam03968 243231006619 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 243231006620 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243231006621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231006622 active site 243231006623 phosphorylation site [posttranslational modification] 243231006624 intermolecular recognition site; other site 243231006625 dimerization interface [polypeptide binding]; other site 243231006626 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231006627 Zn2+ binding site [ion binding]; other site 243231006628 Mg2+ binding site [ion binding]; other site 243231006629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231006630 active site 243231006631 motif I; other site 243231006632 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 243231006633 motif II; other site 243231006634 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 243231006635 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 243231006636 putative active site [active] 243231006637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 243231006638 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 243231006639 CTP synthetase; Validated; Region: pyrG; PRK05380 243231006640 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 243231006641 Catalytic site [active] 243231006642 active site 243231006643 UTP binding site [chemical binding]; other site 243231006644 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 243231006645 active site 243231006646 putative oxyanion hole; other site 243231006647 catalytic triad [active] 243231006648 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 243231006649 Ligand binding site; other site 243231006650 oligomer interface; other site 243231006651 conserved nucleotide sequence; similar to other Geobacter species; GSUR0205 243231006652 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 243231006653 Protein of unknown function (DUF422); Region: DUF422; cl00991 243231006654 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 243231006655 mce related protein; Region: MCE; pfam02470 243231006656 Permease; Region: Permease; pfam02405 243231006657 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 243231006658 substrate binding site [chemical binding]; other site 243231006659 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 243231006660 substrate binding site [chemical binding]; other site 243231006661 ligand binding site [chemical binding]; other site 243231006662 conserved nucleotide sequence; similar to other Geobacter species; GSUR0206 243231006663 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 243231006664 conserved nucleotide sequence; similar to other Geobacter species; GSUR0207 243231006665 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 243231006666 DNA-binding site [nucleotide binding]; DNA binding site 243231006667 RNA-binding motif; other site 243231006668 palindrome; GSUR0208 243231006669 2-isopropylmalate synthase; Validated; Region: PRK00915 243231006670 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 243231006671 active site 243231006672 catalytic residues [active] 243231006673 metal binding site [ion binding]; metal-binding site 243231006674 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 243231006675 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 243231006676 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 243231006677 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 243231006678 ketol-acid reductoisomerase; Provisional; Region: PRK05479 243231006679 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 243231006680 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 243231006681 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 243231006682 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 243231006683 putative valine binding site [chemical binding]; other site 243231006684 dimer interface [polypeptide binding]; other site 243231006685 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 243231006686 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 243231006687 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 243231006688 PYR/PP interface [polypeptide binding]; other site 243231006689 dimer interface [polypeptide binding]; other site 243231006690 TPP binding site [chemical binding]; other site 243231006691 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 243231006692 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 243231006693 TPP-binding site [chemical binding]; other site 243231006694 dimer interface [polypeptide binding]; other site 243231006695 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 243231006696 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 243231006697 Glycoprotease family; Region: Peptidase_M22; pfam00814 243231006698 RIP metalloprotease RseP; Region: TIGR00054 243231006699 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 243231006700 active site 243231006701 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 243231006702 protein binding site [polypeptide binding]; other site 243231006703 putative substrate binding region [chemical binding]; other site 243231006704 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 243231006705 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 243231006706 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 243231006707 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 243231006708 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 243231006709 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 243231006710 active site 243231006711 dimer interface [polypeptide binding]; other site 243231006712 conserved nucleotide sequence; similar to other Geobacter species; GSUR0209 243231006713 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243231006714 hinge region; other site 243231006715 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243231006716 putative nucleotide binding site [chemical binding]; other site 243231006717 uridine monophosphate binding site [chemical binding]; other site 243231006718 homohexameric interface [polypeptide binding]; other site 243231006719 elongation factor Ts; Reviewed; Region: tsf; PRK12332 243231006720 UBA/TS-N domain; Region: UBA; pfam00627 243231006721 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243231006722 rRNA interaction site [nucleotide binding]; other site 243231006723 S8 interaction site; other site 243231006724 putative laminin-1 binding site; other site 243231006725 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243231006726 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 243231006727 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 243231006728 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 243231006729 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 243231006730 AAA domain; Region: AAA_18; pfam13238 243231006731 BON domain; Region: BON; pfam04972 243231006732 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 243231006733 response regulator PleD; Reviewed; Region: pleD; PRK09581 243231006734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231006735 active site 243231006736 phosphorylation site [posttranslational modification] 243231006737 intermolecular recognition site; other site 243231006738 dimerization interface [polypeptide binding]; other site 243231006739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231006740 putative active site [active] 243231006741 heme pocket [chemical binding]; other site 243231006742 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231006743 metal binding site [ion binding]; metal-binding site 243231006744 active site 243231006745 I-site; other site 243231006746 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231006747 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 243231006748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231006749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231006750 dimerization interface [polypeptide binding]; other site 243231006751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231006752 dimer interface [polypeptide binding]; other site 243231006753 phosphorylation site [posttranslational modification] 243231006754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231006755 ATP binding site [chemical binding]; other site 243231006756 Mg2+ binding site [ion binding]; other site 243231006757 G-X-G motif; other site 243231006758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231006759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231006760 active site 243231006761 phosphorylation site [posttranslational modification] 243231006762 intermolecular recognition site; other site 243231006763 dimerization interface [polypeptide binding]; other site 243231006764 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243231006765 putative binding surface; other site 243231006766 active site 243231006767 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 243231006768 MgtC family; Region: MgtC; pfam02308 243231006769 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 243231006770 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 243231006771 G1 box; other site 243231006772 GTP/Mg2+ binding site [chemical binding]; other site 243231006773 G2 box; other site 243231006774 Switch I region; other site 243231006775 G3 box; other site 243231006776 Switch II region; other site 243231006777 G4 box; other site 243231006778 G5 box; other site 243231006779 Plus-3 domain; Region: Plus-3; cl02186 243231006780 Sporulation related domain; Region: SPOR; pfam05036 243231006781 Sporulation related domain; Region: SPOR; pfam05036 243231006782 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 243231006783 elongation factor G; Reviewed; Region: PRK12740 243231006784 G1 box; other site 243231006785 putative GEF interaction site [polypeptide binding]; other site 243231006786 GTP/Mg2+ binding site [chemical binding]; other site 243231006787 Switch I region; other site 243231006788 G2 box; other site 243231006789 G3 box; other site 243231006790 Switch II region; other site 243231006791 G4 box; other site 243231006792 G5 box; other site 243231006793 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243231006794 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243231006795 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243231006796 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243231006797 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243231006798 nucleotide binding site [chemical binding]; other site 243231006799 Type III pantothenate kinase; Region: Pan_kinase; cl17198 243231006800 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 243231006801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243231006802 putative DNA binding site [nucleotide binding]; other site 243231006803 dimerization interface [polypeptide binding]; other site 243231006804 putative Zn2+ binding site [ion binding]; other site 243231006805 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 243231006806 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 243231006807 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 243231006808 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 243231006809 dimerization interface [polypeptide binding]; other site 243231006810 active site 243231006811 conserved nucleotide sequence; similar to other Geobacter species; GSUR0210 243231006812 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231006813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231006814 dimerization interface [polypeptide binding]; other site 243231006815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231006816 metal binding site [ion binding]; metal-binding site 243231006817 active site 243231006818 I-site; other site 243231006819 Tetratricopeptide repeat; Region: TPR_6; pfam13174 243231006820 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243231006821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231006822 dimer interface [polypeptide binding]; other site 243231006823 phosphorylation site [posttranslational modification] 243231006824 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 243231006825 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243231006826 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231006827 Zn2+ binding site [ion binding]; other site 243231006828 Mg2+ binding site [ion binding]; other site 243231006829 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 243231006830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231006831 active site 243231006832 phosphorylation site [posttranslational modification] 243231006833 intermolecular recognition site; other site 243231006834 dimerization interface [polypeptide binding]; other site 243231006835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231006836 Walker A motif; other site 243231006837 ATP binding site [chemical binding]; other site 243231006838 Walker B motif; other site 243231006839 arginine finger; other site 243231006840 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231006841 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 243231006842 GAF domain; Region: GAF_3; pfam13492 243231006843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231006844 ATP binding site [chemical binding]; other site 243231006845 G-X-G motif; other site 243231006846 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 243231006847 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 243231006848 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 243231006849 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 243231006850 PEP-CTERM motif; Region: VPEP; pfam07589 243231006851 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231006852 Interdomain contacts; other site 243231006853 Cytokine receptor motif; other site 243231006854 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231006855 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 243231006856 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231006857 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231006858 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 243231006859 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231006860 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231006861 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231006862 PEP-CTERM motif; Region: VPEP; pfam07589 243231006863 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 243231006864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243231006865 acyl-activating enzyme (AAE) consensus motif; other site 243231006866 active site 243231006867 AMP binding site [chemical binding]; other site 243231006868 CoA binding site [chemical binding]; other site 243231006869 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 243231006870 putative active site [active] 243231006871 putative metal binding site [ion binding]; other site 243231006872 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231006873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231006874 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 243231006875 active site 243231006876 dimer interface [polypeptide binding]; other site 243231006877 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 243231006878 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 243231006879 Ligand Binding Site [chemical binding]; other site 243231006880 Molecular Tunnel; other site 243231006881 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 243231006882 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 243231006883 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 243231006884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243231006885 acyl-activating enzyme (AAE) consensus motif; other site 243231006886 AMP binding site [chemical binding]; other site 243231006887 active site 243231006888 CoA binding site [chemical binding]; other site 243231006889 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 243231006890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231006891 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 243231006892 putative ADP-binding pocket [chemical binding]; other site 243231006893 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 243231006894 putative active site [active] 243231006895 putative metal binding site [ion binding]; other site 243231006896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 243231006897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 243231006898 serine O-acetyltransferase; Region: cysE; TIGR01172 243231006899 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243231006900 trimer interface [polypeptide binding]; other site 243231006901 active site 243231006902 substrate binding site [chemical binding]; other site 243231006903 CoA binding site [chemical binding]; other site 243231006904 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243231006905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243231006906 active site 243231006907 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231006908 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243231006909 active site 243231006910 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 243231006911 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 243231006912 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 243231006913 M28 Zn-Peptidases; Region: M28_like_3; cd05644 243231006914 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 243231006915 active site 243231006916 metal binding site [ion binding]; metal-binding site 243231006917 OpgC protein; Region: OpgC_C; cl17858 243231006918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 243231006919 FOG: CBS domain [General function prediction only]; Region: COG0517 243231006920 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 243231006921 FOG: CBS domain [General function prediction only]; Region: COG0517 243231006922 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243231006923 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 243231006924 Substrate binding site; other site 243231006925 metal-binding site 243231006926 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 243231006927 NeuB family; Region: NeuB; pfam03102 243231006928 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 243231006929 NeuB binding interface [polypeptide binding]; other site 243231006930 putative substrate binding site [chemical binding]; other site 243231006931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243231006932 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 243231006933 ligand binding site; other site 243231006934 tetramer interface; other site 243231006935 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 243231006936 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 243231006937 putative trimer interface [polypeptide binding]; other site 243231006938 putative CoA binding site [chemical binding]; other site 243231006939 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243231006940 inhibitor-cofactor binding pocket; inhibition site 243231006941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231006942 catalytic residue [active] 243231006943 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 243231006944 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 243231006945 NAD binding site [chemical binding]; other site 243231006946 substrate binding site [chemical binding]; other site 243231006947 active site 243231006948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231006949 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 243231006950 putative ADP-binding pocket [chemical binding]; other site 243231006951 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 243231006952 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231006953 DXD motif; other site 243231006954 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 243231006955 exosortase A; Region: exosortase_1; TIGR03109 243231006956 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 243231006957 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 243231006958 putative active site [active] 243231006959 putative catalytic site [active] 243231006960 uncharacterized protein, PEP-CTERM system associated; Region: pepcterm_hypo_1; TIGR03016 243231006961 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 243231006962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231006963 Walker A motif; other site 243231006964 ATP binding site [chemical binding]; other site 243231006965 Walker B motif; other site 243231006966 arginine finger; other site 243231006967 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 243231006968 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 243231006969 Chain length determinant protein; Region: Wzz; pfam02706 243231006970 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 243231006971 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 243231006972 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 243231006973 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 243231006974 SLBB domain; Region: SLBB; pfam10531 243231006975 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 243231006976 Bacterial sugar transferase; Region: Bac_transf; pfam02397 243231006977 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 243231006978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006979 binding surface 243231006980 TPR motif; other site 243231006981 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006982 binding surface 243231006983 TPR motif; other site 243231006984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006985 binding surface 243231006986 TPR motif; other site 243231006987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006988 binding surface 243231006989 TPR motif; other site 243231006990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006991 TPR motif; other site 243231006992 binding surface 243231006993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006994 binding surface 243231006995 TPR motif; other site 243231006996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231006997 binding surface 243231006998 TPR motif; other site 243231006999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231007000 binding surface 243231007001 TPR motif; other site 243231007002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231007003 TPR motif; other site 243231007004 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231007005 palindrome; GSUR0211 243231007006 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231007007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007008 active site 243231007009 phosphorylation site [posttranslational modification] 243231007010 intermolecular recognition site; other site 243231007011 dimerization interface [polypeptide binding]; other site 243231007012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231007013 Walker A motif; other site 243231007014 ATP binding site [chemical binding]; other site 243231007015 Walker B motif; other site 243231007016 arginine finger; other site 243231007017 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231007018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231007019 dimer interface [polypeptide binding]; other site 243231007020 phosphorylation site [posttranslational modification] 243231007021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007022 ATP binding site [chemical binding]; other site 243231007023 Mg2+ binding site [ion binding]; other site 243231007024 G-X-G motif; other site 243231007025 CAAX prenyl protease-related protein; Region: pepcterm_CAAX; TIGR03008 243231007026 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243231007027 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243231007028 ligand binding site [chemical binding]; other site 243231007029 flexible hinge region; other site 243231007030 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 243231007031 putative switch regulator; other site 243231007032 non-specific DNA interactions [nucleotide binding]; other site 243231007033 DNA binding site [nucleotide binding] 243231007034 sequence specific DNA binding site [nucleotide binding]; other site 243231007035 putative cAMP binding site [chemical binding]; other site 243231007036 PEP-CTERM motif; Region: VPEP; pfam07589 243231007037 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243231007038 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007039 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231007040 heme-binding residues [chemical binding]; other site 243231007041 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007042 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 243231007043 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 243231007044 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 243231007045 Protein of unknown function (DUF512); Region: DUF512; pfam04459 243231007046 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243231007047 bacterial Hfq-like; Region: Hfq; cd01716 243231007048 hexamer interface [polypeptide binding]; other site 243231007049 Sm1 motif; other site 243231007050 RNA binding site [nucleotide binding]; other site 243231007051 Sm2 motif; other site 243231007052 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 243231007053 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 243231007054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007055 ATP binding site [chemical binding]; other site 243231007056 Mg2+ binding site [ion binding]; other site 243231007057 G-X-G motif; other site 243231007058 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 243231007059 ATP binding site [chemical binding]; other site 243231007060 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 243231007061 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 243231007062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231007063 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 243231007064 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243231007065 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 243231007066 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243231007067 TM-ABC transporter signature motif; other site 243231007068 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243231007069 TM-ABC transporter signature motif; other site 243231007070 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243231007071 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243231007072 Walker A/P-loop; other site 243231007073 ATP binding site [chemical binding]; other site 243231007074 Q-loop/lid; other site 243231007075 ABC transporter signature motif; other site 243231007076 Walker B; other site 243231007077 D-loop; other site 243231007078 H-loop/switch region; other site 243231007079 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243231007080 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243231007081 Walker A/P-loop; other site 243231007082 ATP binding site [chemical binding]; other site 243231007083 Q-loop/lid; other site 243231007084 ABC transporter signature motif; other site 243231007085 Walker B; other site 243231007086 D-loop; other site 243231007087 H-loop/switch region; other site 243231007088 FOG: CBS domain [General function prediction only]; Region: COG0517 243231007089 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 243231007090 palindrome; GSUR0212 243231007091 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 243231007092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231007093 catalytic residue [active] 243231007094 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 243231007095 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243231007096 trimerization site [polypeptide binding]; other site 243231007097 active site 243231007098 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 243231007099 NifU-like domain; Region: NifU; cl00484 243231007100 conserved nucleotide sequence; similar to other Geobacter species; GSUR0213 243231007101 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243231007102 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 243231007103 active site 243231007104 substrate binding site [chemical binding]; other site 243231007105 metal binding site [ion binding]; metal-binding site 243231007106 conserved nucleotide sequence; similar to other Geobacter species; GSUR0214 243231007107 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 243231007108 nudix motif; other site 243231007109 PAS domain S-box; Region: sensory_box; TIGR00229 243231007110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231007111 putative active site [active] 243231007112 heme pocket [chemical binding]; other site 243231007113 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231007114 metal binding site [ion binding]; metal-binding site 243231007115 active site 243231007116 I-site; other site 243231007117 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231007118 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 243231007119 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 243231007120 lipoyl attachment site [posttranslational modification]; other site 243231007121 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 243231007122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243231007123 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 243231007124 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243231007125 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 243231007126 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243231007127 carboxyltransferase (CT) interaction site; other site 243231007128 biotinylation site [posttranslational modification]; other site 243231007129 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243231007130 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243231007131 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 243231007132 active site 243231007133 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 243231007134 trimer interface [polypeptide binding]; other site 243231007135 active site 243231007136 dimer interface [polypeptide binding]; other site 243231007137 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 243231007138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231007139 TPR motif; other site 243231007140 binding surface 243231007141 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231007142 binding surface 243231007143 TPR motif; other site 243231007144 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 243231007145 active site 243231007146 dimer interface [polypeptide binding]; other site 243231007147 metal binding site [ion binding]; metal-binding site 243231007148 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 243231007149 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 243231007150 ADP binding site [chemical binding]; other site 243231007151 magnesium binding site [ion binding]; other site 243231007152 putative shikimate binding site; other site 243231007153 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 243231007154 Tetramer interface [polypeptide binding]; other site 243231007155 active site 243231007156 FMN-binding site [chemical binding]; other site 243231007157 AMIN domain; Region: AMIN; pfam11741 243231007158 AMIN domain; Region: AMIN; pfam11741 243231007159 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 243231007160 Secretin and TonB N terminus short domain; Region: STN; smart00965 243231007161 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 243231007162 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 243231007163 Pilus assembly protein, PilP; Region: PilP; cl19831 243231007164 Pilus assembly protein, PilO; Region: PilO; pfam04350 243231007165 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 243231007166 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 243231007167 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 243231007168 Cell division protein FtsA; Region: FtsA; cl17206 243231007169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231007170 non-specific DNA binding site [nucleotide binding]; other site 243231007171 salt bridge; other site 243231007172 sequence-specific DNA binding site [nucleotide binding]; other site 243231007173 PilX N-terminal; Region: PilX_N; pfam14341 243231007174 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243231007175 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243231007176 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 243231007177 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 243231007178 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 243231007179 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 243231007180 catalytic residues [active] 243231007181 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 243231007182 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231007183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007184 active site 243231007185 phosphorylation site [posttranslational modification] 243231007186 intermolecular recognition site; other site 243231007187 dimerization interface [polypeptide binding]; other site 243231007188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231007189 Walker A motif; other site 243231007190 ATP binding site [chemical binding]; other site 243231007191 Walker B motif; other site 243231007192 arginine finger; other site 243231007193 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231007194 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 243231007195 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231007196 dimerization interface [polypeptide binding]; other site 243231007197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231007198 dimer interface [polypeptide binding]; other site 243231007199 phosphorylation site [posttranslational modification] 243231007200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007201 ATP binding site [chemical binding]; other site 243231007202 Mg2+ binding site [ion binding]; other site 243231007203 G-X-G motif; other site 243231007204 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 243231007205 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 243231007206 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 243231007207 GAF domain; Region: GAF_2; pfam13185 243231007208 PAS fold; Region: PAS_4; pfam08448 243231007209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231007210 metal binding site [ion binding]; metal-binding site 243231007211 active site 243231007212 I-site; other site 243231007213 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231007214 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 243231007215 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243231007216 active site 243231007217 HIGH motif; other site 243231007218 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243231007219 KMSKS motif; other site 243231007220 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243231007221 tRNA binding surface [nucleotide binding]; other site 243231007222 anticodon binding site; other site 243231007223 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243231007224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007225 active site 243231007226 phosphorylation site [posttranslational modification] 243231007227 intermolecular recognition site; other site 243231007228 dimerization interface [polypeptide binding]; other site 243231007229 Beta-lactamase; Region: Beta-lactamase; pfam00144 243231007230 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 243231007231 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 243231007232 heterotetramer interface [polypeptide binding]; other site 243231007233 active site pocket [active] 243231007234 cleavage site 243231007235 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 243231007236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243231007237 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 243231007238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231007239 nucleotide binding region [chemical binding]; other site 243231007240 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 243231007241 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 243231007242 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 243231007243 acyl-activating enzyme (AAE) consensus motif; other site 243231007244 AMP binding site [chemical binding]; other site 243231007245 active site 243231007246 CoA binding site [chemical binding]; other site 243231007247 indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK06274 243231007248 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 243231007249 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 243231007250 dimer interface [polypeptide binding]; other site 243231007251 PYR/PP interface [polypeptide binding]; other site 243231007252 TPP binding site [chemical binding]; other site 243231007253 substrate binding site [chemical binding]; other site 243231007254 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 243231007255 TPP-binding site; other site 243231007256 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 243231007257 4Fe-4S binding domain; Region: Fer4; pfam00037 243231007258 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231007259 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 243231007260 DctM-like transporters; Region: DctM; pfam06808 243231007261 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 243231007262 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 243231007263 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 243231007264 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 243231007265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243231007266 Coenzyme A binding pocket [chemical binding]; other site 243231007267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007268 active site 243231007269 phosphorylation site [posttranslational modification] 243231007270 intermolecular recognition site; other site 243231007271 dimerization interface [polypeptide binding]; other site 243231007272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231007273 metal binding site [ion binding]; metal-binding site 243231007274 active site 243231007275 I-site; other site 243231007276 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 243231007277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231007278 Zn2+ binding site [ion binding]; other site 243231007279 Mg2+ binding site [ion binding]; other site 243231007280 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 243231007281 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243231007282 Walker A/P-loop; other site 243231007283 ATP binding site [chemical binding]; other site 243231007284 Q-loop/lid; other site 243231007285 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 243231007286 ABC transporter signature motif; other site 243231007287 Walker B; other site 243231007288 D-loop; other site 243231007289 H-loop/switch region; other site 243231007290 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 243231007291 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 243231007292 homodimer interface [polypeptide binding]; other site 243231007293 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 243231007294 active site pocket [active] 243231007295 recombination factor protein RarA; Reviewed; Region: PRK13342 243231007296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231007297 Walker A motif; other site 243231007298 ATP binding site [chemical binding]; other site 243231007299 Walker B motif; other site 243231007300 arginine finger; other site 243231007301 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 243231007302 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 243231007303 active site 243231007304 ADP/pyrophosphate binding site [chemical binding]; other site 243231007305 dimerization interface [polypeptide binding]; other site 243231007306 allosteric effector site; other site 243231007307 fructose-1,6-bisphosphate binding site; other site 243231007308 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243231007309 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 243231007310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231007311 motif II; other site 243231007312 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 243231007313 active site 243231007314 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 243231007315 RNA/DNA hybrid binding site [nucleotide binding]; other site 243231007316 active site 243231007317 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243231007318 putative acyl-acceptor binding pocket; other site 243231007319 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 243231007320 Ca2+ binding site [ion binding]; other site 243231007321 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 243231007322 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231007323 Ca2+ binding site [ion binding]; other site 243231007324 Cadherin repeat-like domain; Region: CA_like; cl15786 243231007325 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 243231007326 Cadherin repeat-like domain; Region: CA_like; cl15786 243231007327 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 243231007328 Cadherin repeat-like domain; Region: CA_like; cl15786 243231007329 Cadherin repeat-like domain; Region: CA_like; cl15786 243231007330 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 243231007331 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243231007332 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 243231007333 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 243231007334 Subtilase family; Region: Peptidase_S8; pfam00082 243231007335 active site 243231007336 catalytic residues [active] 243231007337 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 243231007338 six hairpins; GSUR0073 243231007339 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 243231007340 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 243231007341 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 243231007342 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243231007343 rod shape-determining protein MreD; Region: MreD; cl01087 243231007344 rod shape-determining protein MreC; Provisional; Region: PRK13922 243231007345 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 243231007346 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 243231007347 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 243231007348 substrate binding site; other site 243231007349 tetramer interface; other site 243231007350 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 243231007351 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231007352 active site 243231007353 motif I; other site 243231007354 motif II; other site 243231007355 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 243231007356 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 243231007357 putative ribose interaction site [chemical binding]; other site 243231007358 putative ADP binding site [chemical binding]; other site 243231007359 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 243231007360 active site 243231007361 nucleotide binding site [chemical binding]; other site 243231007362 HIGH motif; other site 243231007363 KMSKS motif; other site 243231007364 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 243231007365 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 243231007366 dimer interface [polypeptide binding]; other site 243231007367 active site 243231007368 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243231007369 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243231007370 active site 243231007371 rod shape-determining protein MreB; Provisional; Region: PRK13927 243231007372 MreB and similar proteins; Region: MreB_like; cd10225 243231007373 nucleotide binding site [chemical binding]; other site 243231007374 Mg binding site [ion binding]; other site 243231007375 putative protofilament interaction site [polypeptide binding]; other site 243231007376 RodZ interaction site [polypeptide binding]; other site 243231007377 SurA N-terminal domain; Region: SurA_N_3; cl07813 243231007378 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 243231007379 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 243231007380 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 243231007381 active site 243231007382 ATP binding site [chemical binding]; other site 243231007383 substrate binding site [chemical binding]; other site 243231007384 YaeQ protein; Region: YaeQ; pfam07152 243231007385 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 243231007386 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231007387 ABC transporter; Region: ABC_tran_2; pfam12848 243231007388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 243231007389 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243231007390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007391 active site 243231007392 phosphorylation site [posttranslational modification] 243231007393 intermolecular recognition site; other site 243231007394 dimerization interface [polypeptide binding]; other site 243231007395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231007396 Zn2+ binding site [ion binding]; other site 243231007397 Mg2+ binding site [ion binding]; other site 243231007398 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 243231007399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231007400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231007401 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 243231007402 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 243231007403 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 243231007404 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 243231007405 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231007406 P-loop; other site 243231007407 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 243231007408 ACS interaction site; other site 243231007409 CODH interaction site; other site 243231007410 cubane metal cluster (B-cluster) [ion binding]; other site 243231007411 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 243231007412 PAS domain; Region: PAS_9; pfam13426 243231007413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231007414 putative active site [active] 243231007415 heme pocket [chemical binding]; other site 243231007416 LytTr DNA-binding domain; Region: LytTR; smart00850 243231007417 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 243231007418 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 243231007419 dimer interface [polypeptide binding]; other site 243231007420 active site 243231007421 heme binding site [chemical binding]; other site 243231007422 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 243231007423 palindrome; GSUR0215 243231007424 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 243231007425 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 243231007426 dimer interface [polypeptide binding]; other site 243231007427 active site 243231007428 glycine loop; other site 243231007429 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 243231007430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231007431 FeS/SAM binding site; other site 243231007432 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243231007433 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 243231007434 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 243231007435 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243231007436 TIGR02687 family protein; Region: TIGR02687 243231007437 PglZ domain; Region: PglZ; pfam08665 243231007438 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243231007439 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 243231007440 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 243231007441 conserved nucleotide sequence; similar to other Geobacter species; GSUR0216 243231007442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231007443 salt bridge; other site 243231007444 non-specific DNA binding site [nucleotide binding]; other site 243231007445 sequence-specific DNA binding site [nucleotide binding]; other site 243231007446 Integrase; Region: Integrase_1; pfam12835 243231007447 Helix-turn-helix domain; Region: HTH_17; cl17695 243231007448 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 243231007449 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 243231007450 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 243231007451 active site 243231007452 DNA binding site [nucleotide binding] 243231007453 Int/Topo IB signature motif; other site 243231007454 integrase; Provisional; Region: PRK09692 243231007455 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 243231007456 active site 243231007457 Int/Topo IB signature motif; other site 243231007458 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 243231007459 DNA binding site [nucleotide binding] 243231007460 dimer interface [polypeptide binding]; other site 243231007461 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 243231007462 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243231007463 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243231007464 catalytic residue [active] 243231007465 Domain of unknown function DUF87; Region: DUF87; cl19135 243231007466 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 243231007467 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231007468 Zn2+ binding site [ion binding]; other site 243231007469 Mg2+ binding site [ion binding]; other site 243231007470 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 243231007471 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243231007472 catalytic residues [active] 243231007473 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 243231007474 Transposase; Region: HTH_Tnp_1; cl17663 243231007475 putative transposase OrfB; Reviewed; Region: PHA02517 243231007476 HTH-like domain; Region: HTH_21; pfam13276 243231007477 Integrase core domain; Region: rve; pfam00665 243231007478 Integrase core domain; Region: rve_3; cl15866 243231007479 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 243231007480 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243231007481 MMPL family; Region: MMPL; cl14618 243231007482 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231007483 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243231007484 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231007485 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243231007486 Outer membrane efflux protein; Region: OEP; pfam02321 243231007487 Outer membrane efflux protein; Region: OEP; pfam02321 243231007488 Transposase; Region: HTH_Tnp_1; cl17663 243231007489 putative transposase OrfB; Reviewed; Region: PHA02517 243231007490 HTH-like domain; Region: HTH_21; pfam13276 243231007491 Integrase core domain; Region: rve; pfam00665 243231007492 Integrase core domain; Region: rve_3; cl15866 243231007493 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 243231007494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231007495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231007496 dimerization interface [polypeptide binding]; other site 243231007497 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231007498 dimer interface [polypeptide binding]; other site 243231007499 phosphorylation site [posttranslational modification] 243231007500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007501 ATP binding site [chemical binding]; other site 243231007502 Mg2+ binding site [ion binding]; other site 243231007503 G-X-G motif; other site 243231007504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231007505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007506 active site 243231007507 phosphorylation site [posttranslational modification] 243231007508 intermolecular recognition site; other site 243231007509 dimerization interface [polypeptide binding]; other site 243231007510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231007511 DNA binding site [nucleotide binding] 243231007512 Domain of unknown function DUF302; Region: DUF302; cl01364 243231007513 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243231007514 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243231007515 metal-binding site [ion binding] 243231007516 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243231007517 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243231007518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243231007519 dimerization interface [polypeptide binding]; other site 243231007520 putative DNA binding site [nucleotide binding]; other site 243231007521 putative Zn2+ binding site [ion binding]; other site 243231007522 conserved nucleotide sequence; similar to other Geobacter species; GSUR0217 243231007523 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243231007524 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243231007525 dimer interface [polypeptide binding]; other site 243231007526 ssDNA binding site [nucleotide binding]; other site 243231007527 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243231007528 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 243231007529 ADP-ribosyltransferase; Provisional; Region: alt; PHA02566 243231007530 TSCPD domain; Region: TSCPD; pfam12637 243231007531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231007532 Walker A motif; other site 243231007533 ATP binding site [chemical binding]; other site 243231007534 Walker B motif; other site 243231007535 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 243231007536 WGR domain of bacterial DNA ligases; Region: WGR_DNA_ligase; cd07998 243231007537 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 243231007538 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 243231007539 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 243231007540 metal ion-dependent adhesion site (MIDAS); other site 243231007541 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243231007542 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 243231007543 Domain of unknown function (DUF305); Region: DUF305; cl17794 243231007544 CHC2 zinc finger; Region: zf-CHC2; cl17510 243231007545 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 243231007546 MPN+ (JAMM) motif; other site 243231007547 Zinc-binding site [ion binding]; other site 243231007548 conserved nucleotide sequence; similar to other Geobacter species; GSUR0218 243231007549 Transposase; Region: HTH_Tnp_1; cl17663 243231007550 putative transposase OrfB; Reviewed; Region: PHA02517 243231007551 HTH-like domain; Region: HTH_21; pfam13276 243231007552 Integrase core domain; Region: rve; pfam00665 243231007553 Integrase core domain; Region: rve_3; cl15866 243231007554 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231007555 ligand binding site [chemical binding]; other site 243231007556 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 243231007557 Replication initiator protein A; Region: RPA; cl19398 243231007558 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243231007559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 243231007560 DNA binding residues [nucleotide binding] 243231007561 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 243231007562 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231007563 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 243231007564 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 243231007565 Fic/DOC family; Region: Fic; pfam02661 243231007566 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243231007567 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 243231007568 active site 243231007569 NTP binding site [chemical binding]; other site 243231007570 metal binding triad [ion binding]; metal-binding site 243231007571 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243231007572 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 243231007573 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 243231007574 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 243231007575 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231007576 FtsX-like permease family; Region: FtsX; pfam02687 243231007577 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231007578 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243231007579 FtsX-like permease family; Region: FtsX; pfam02687 243231007580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231007581 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231007582 Walker A/P-loop; other site 243231007583 ATP binding site [chemical binding]; other site 243231007584 Q-loop/lid; other site 243231007585 ABC transporter signature motif; other site 243231007586 Walker B; other site 243231007587 D-loop; other site 243231007588 H-loop/switch region; other site 243231007589 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231007590 PAS domain; Region: PAS_8; pfam13188 243231007591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007592 ATP binding site [chemical binding]; other site 243231007593 Mg2+ binding site [ion binding]; other site 243231007594 G-X-G motif; other site 243231007595 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 243231007596 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 243231007597 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 243231007598 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 243231007599 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 243231007600 phosphoglycolate phosphatase; Provisional; Region: PRK13222 243231007601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243231007602 active site 243231007603 motif I; other site 243231007604 motif II; other site 243231007605 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231007606 diiron binding motif [ion binding]; other site 243231007607 GMP synthase; Reviewed; Region: guaA; PRK00074 243231007608 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 243231007609 AMP/PPi binding site [chemical binding]; other site 243231007610 candidate oxyanion hole; other site 243231007611 catalytic triad [active] 243231007612 potential glutamine specificity residues [chemical binding]; other site 243231007613 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 243231007614 ATP Binding subdomain [chemical binding]; other site 243231007615 Ligand Binding sites [chemical binding]; other site 243231007616 Dimerization subdomain; other site 243231007617 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 243231007618 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 243231007619 active site 243231007620 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 243231007621 conserved nucleotide sequence; similar to other Geobacter species; GSUR0219 243231007622 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 243231007623 oligomer interface [polypeptide binding]; other site 243231007624 active site 243231007625 metal binding site [ion binding]; metal-binding site 243231007626 Bifunctional nuclease; Region: DNase-RNase; pfam02577 243231007627 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 243231007628 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243231007629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231007630 FeS/SAM binding site; other site 243231007631 TRAM domain; Region: TRAM; pfam01938 243231007632 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 243231007633 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 243231007634 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231007635 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 243231007636 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231007637 heme-binding residues [chemical binding]; other site 243231007638 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 243231007639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243231007640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231007641 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243231007642 dimerization interface [polypeptide binding]; other site 243231007643 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231007644 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231007645 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231007646 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231007647 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 243231007648 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 243231007649 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 243231007650 DNA polymerase III, delta subunit; Region: holA; TIGR01128 243231007651 Lipopolysaccharide-assembly; Region: LptE; pfam04390 243231007652 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 243231007653 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243231007654 active site 243231007655 HIGH motif; other site 243231007656 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243231007657 KMSKS motif; other site 243231007658 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 243231007659 tRNA binding surface [nucleotide binding]; other site 243231007660 conserved nucleotide sequence; similar to other Geobacter species; GSUR0220 243231007661 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007662 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007663 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007664 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007665 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231007666 heme-binding residues [chemical binding]; other site 243231007667 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007668 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007669 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 243231007670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007671 active site 243231007672 phosphorylation site [posttranslational modification] 243231007673 intermolecular recognition site; other site 243231007674 dimerization interface [polypeptide binding]; other site 243231007675 GAF domain; Region: GAF_3; pfam13492 243231007676 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 243231007677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007678 active site 243231007679 phosphorylation site [posttranslational modification] 243231007680 intermolecular recognition site; other site 243231007681 dimerization interface [polypeptide binding]; other site 243231007682 CheB methylesterase; Region: CheB_methylest; pfam01339 243231007683 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 243231007684 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243231007685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231007686 S-adenosylmethionine binding site [chemical binding]; other site 243231007687 HEAT repeats; Region: HEAT_2; pfam13646 243231007688 HEAT repeats; Region: HEAT_2; pfam13646 243231007689 HEAT repeats; Region: HEAT_2; pfam13646 243231007690 HEAT repeats; Region: HEAT_2; pfam13646 243231007691 HEAT repeats; Region: HEAT_2; pfam13646 243231007692 HEAT repeats; Region: HEAT_2; pfam13646 243231007693 HEAT repeats; Region: HEAT_2; pfam13646 243231007694 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 243231007695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007696 active site 243231007697 phosphorylation site [posttranslational modification] 243231007698 intermolecular recognition site; other site 243231007699 dimerization interface [polypeptide binding]; other site 243231007700 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 243231007701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007702 active site 243231007703 phosphorylation site [posttranslational modification] 243231007704 intermolecular recognition site; other site 243231007705 dimerization interface [polypeptide binding]; other site 243231007706 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231007707 putative CheA interaction surface; other site 243231007708 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 243231007709 AAA domain; Region: AAA_22; pfam13401 243231007710 Walker A motif; other site 243231007711 ATP binding site [chemical binding]; other site 243231007712 Walker B motif; other site 243231007713 arginine finger; other site 243231007714 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243231007715 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 243231007716 putative binding surface; other site 243231007717 active site 243231007718 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 243231007719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007720 ATP binding site [chemical binding]; other site 243231007721 Mg2+ binding site [ion binding]; other site 243231007722 G-X-G motif; other site 243231007723 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 243231007724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007725 active site 243231007726 phosphorylation site [posttranslational modification] 243231007727 intermolecular recognition site; other site 243231007728 dimerization interface [polypeptide binding]; other site 243231007729 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 243231007730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231007731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007732 active site 243231007733 phosphorylation site [posttranslational modification] 243231007734 intermolecular recognition site; other site 243231007735 dimerization interface [polypeptide binding]; other site 243231007736 GTP-binding protein Der; Reviewed; Region: PRK00093 243231007737 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243231007738 G1 box; other site 243231007739 GTP/Mg2+ binding site [chemical binding]; other site 243231007740 Switch I region; other site 243231007741 G2 box; other site 243231007742 Switch II region; other site 243231007743 G3 box; other site 243231007744 G4 box; other site 243231007745 G5 box; other site 243231007746 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243231007747 G1 box; other site 243231007748 GTP/Mg2+ binding site [chemical binding]; other site 243231007749 Switch I region; other site 243231007750 G2 box; other site 243231007751 G3 box; other site 243231007752 Switch II region; other site 243231007753 G4 box; other site 243231007754 G5 box; other site 243231007755 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 243231007756 GTPase Era; Reviewed; Region: era; PRK00089 243231007757 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 243231007758 G1 box; other site 243231007759 GTP/Mg2+ binding site [chemical binding]; other site 243231007760 Switch I region; other site 243231007761 G2 box; other site 243231007762 Switch II region; other site 243231007763 G3 box; other site 243231007764 G4 box; other site 243231007765 G5 box; other site 243231007766 KH domain; Region: KH_2; pfam07650 243231007767 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231007768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231007769 FeS/SAM binding site; other site 243231007770 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 243231007771 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243231007772 dimerization interface [polypeptide binding]; other site 243231007773 active site 243231007774 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 243231007775 dsRNA binding site [nucleotide binding]; other site 243231007776 thymidylate kinase; Validated; Region: tmk; PRK00698 243231007777 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243231007778 TMP-binding site; other site 243231007779 ATP-binding site [chemical binding]; other site 243231007780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231007781 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 243231007782 Walker A motif; other site 243231007783 ATP binding site [chemical binding]; other site 243231007784 Walker B motif; other site 243231007785 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 243231007786 arginine finger; other site 243231007787 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 243231007788 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 243231007789 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243231007790 active site 243231007791 HIGH motif; other site 243231007792 KMSKS motif; other site 243231007793 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243231007794 tRNA binding surface [nucleotide binding]; other site 243231007795 anticodon binding site; other site 243231007796 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 243231007797 putative active site [active] 243231007798 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243231007799 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 243231007800 homotrimer interaction site [polypeptide binding]; other site 243231007801 putative active site [active] 243231007802 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 243231007803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231007804 Zn2+ binding site [ion binding]; other site 243231007805 Mg2+ binding site [ion binding]; other site 243231007806 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243231007807 synthetase active site [active] 243231007808 NTP binding site [chemical binding]; other site 243231007809 metal binding site [ion binding]; metal-binding site 243231007810 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 243231007811 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 243231007812 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 243231007813 Guanylate kinase; Region: Guanylate_kin; pfam00625 243231007814 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243231007815 catalytic site [active] 243231007816 G-X2-G-X-G-K; other site 243231007817 hypothetical protein; Provisional; Region: PRK11820 243231007818 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 243231007819 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 243231007820 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 243231007821 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 243231007822 NAD binding site [chemical binding]; other site 243231007823 homodimer interface [polypeptide binding]; other site 243231007824 active site 243231007825 substrate binding site [chemical binding]; other site 243231007826 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243231007827 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 243231007828 putative NAD(P) binding site [chemical binding]; other site 243231007829 active site 243231007830 putative substrate binding site [chemical binding]; other site 243231007831 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243231007832 putative active site [active] 243231007833 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 243231007834 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 243231007835 active site 243231007836 homodimer interface [polypeptide binding]; other site 243231007837 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243231007838 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243231007839 active site 243231007840 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 243231007841 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 243231007842 active site 243231007843 homodimer interface [polypeptide binding]; other site 243231007844 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 243231007845 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 243231007846 NAD(P) binding site [chemical binding]; other site 243231007847 homodimer interface [polypeptide binding]; other site 243231007848 substrate binding site [chemical binding]; other site 243231007849 active site 243231007850 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 243231007851 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 243231007852 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 243231007853 NADP binding site [chemical binding]; other site 243231007854 active site 243231007855 putative substrate binding site [chemical binding]; other site 243231007856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231007857 S-adenosylmethionine binding site [chemical binding]; other site 243231007858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231007859 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 243231007860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231007861 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231007862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231007863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231007864 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243231007865 putative active site [active] 243231007866 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 243231007867 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231007868 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231007869 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 243231007870 putative metal binding site; other site 243231007871 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 243231007872 GDP-Fucose binding site [chemical binding]; other site 243231007873 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243231007874 putative active site [active] 243231007875 Trm112p-like protein; Region: Trm112p; cl01066 243231007876 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 243231007877 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 243231007878 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 243231007879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231007880 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 243231007881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243231007882 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 243231007883 Walker A/P-loop; other site 243231007884 ATP binding site [chemical binding]; other site 243231007885 Q-loop/lid; other site 243231007886 ABC transporter signature motif; other site 243231007887 Walker B; other site 243231007888 D-loop; other site 243231007889 H-loop/switch region; other site 243231007890 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 243231007891 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 243231007892 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243231007893 inhibitor-cofactor binding pocket; inhibition site 243231007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231007895 catalytic residue [active] 243231007896 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 243231007897 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 243231007898 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 243231007899 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 243231007900 active site 243231007901 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 243231007902 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 243231007903 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 243231007904 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 243231007905 trimer interface [polypeptide binding]; other site 243231007906 active site 243231007907 UDP-GlcNAc binding site [chemical binding]; other site 243231007908 lipid binding site [chemical binding]; lipid-binding site 243231007909 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 243231007910 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243231007911 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 243231007912 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243231007913 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243231007914 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243231007915 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 243231007916 Surface antigen; Region: Bac_surface_Ag; pfam01103 243231007917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231007918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231007919 Walker A/P-loop; other site 243231007920 ATP binding site [chemical binding]; other site 243231007921 Q-loop/lid; other site 243231007922 ABC transporter signature motif; other site 243231007923 Walker B; other site 243231007924 D-loop; other site 243231007925 H-loop/switch region; other site 243231007926 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 243231007927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231007928 FtsX-like permease family; Region: FtsX; pfam02687 243231007929 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 243231007930 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243231007931 dimer interface [polypeptide binding]; other site 243231007932 putative anticodon binding site; other site 243231007933 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 243231007934 motif 1; other site 243231007935 active site 243231007936 motif 2; other site 243231007937 motif 3; other site 243231007938 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007939 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007940 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 243231007941 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007942 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007943 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007944 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007945 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 243231007946 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 243231007947 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 243231007948 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243231007949 EVE domain; Region: EVE; cl00728 243231007950 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 243231007951 Sporulation related domain; Region: SPOR; pfam05036 243231007952 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243231007953 NlpC/P60 family; Region: NLPC_P60; pfam00877 243231007954 peptide chain release factor 2; Validated; Region: prfB; PRK00578 243231007955 Domain of unknown function (DUF3449); Region: DUF3449; pfam11931 243231007956 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243231007957 RF-1 domain; Region: RF-1; pfam00472 243231007958 putative transposase OrfB; Reviewed; Region: PHA02517 243231007959 HTH-like domain; Region: HTH_21; pfam13276 243231007960 Integrase core domain; Region: rve; pfam00665 243231007961 Integrase core domain; Region: rve_3; cl15866 243231007962 Transposase; Region: HTH_Tnp_1; cl17663 243231007963 FOG: CBS domain [General function prediction only]; Region: COG0517 243231007964 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243231007965 Transporter associated domain; Region: CorC_HlyC; smart01091 243231007966 Integral membrane undecaprenol kinase domain co-occurring with type 2 phosphatidic acid phosphatase-like domains; Region: UDPK_IM_PAP2_like; cd14266 243231007967 trimer interface [polypeptide binding]; other site 243231007968 putative active site [active] 243231007969 Zn binding site [ion binding]; other site 243231007970 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 243231007971 active site 243231007972 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 243231007973 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 243231007974 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 243231007975 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 243231007976 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 243231007977 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231007978 Zn2+ binding site [ion binding]; other site 243231007979 Mg2+ binding site [ion binding]; other site 243231007980 enolase; Provisional; Region: eno; PRK00077 243231007981 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243231007982 dimer interface [polypeptide binding]; other site 243231007983 metal binding site [ion binding]; metal-binding site 243231007984 substrate binding pocket [chemical binding]; other site 243231007985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231007986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231007987 active site 243231007988 phosphorylation site [posttranslational modification] 243231007989 intermolecular recognition site; other site 243231007990 dimerization interface [polypeptide binding]; other site 243231007991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231007992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231007993 dimerization interface [polypeptide binding]; other site 243231007994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231007995 dimer interface [polypeptide binding]; other site 243231007996 phosphorylation site [posttranslational modification] 243231007997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231007998 ATP binding site [chemical binding]; other site 243231007999 Mg2+ binding site [ion binding]; other site 243231008000 G-X-G motif; other site 243231008001 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 243231008002 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 243231008003 active site 243231008004 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 243231008005 catalytic triad [active] 243231008006 metal binding site [ion binding]; metal-binding site 243231008007 conserved cis-peptide bond; other site 243231008008 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 243231008009 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 243231008010 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 243231008011 hexamer interface [polypeptide binding]; other site 243231008012 ligand binding site [chemical binding]; other site 243231008013 putative active site [active] 243231008014 NAD(P) binding site [chemical binding]; other site 243231008015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231008016 Zn2+ binding site [ion binding]; other site 243231008017 Mg2+ binding site [ion binding]; other site 243231008018 Cache domain; Region: Cache_1; pfam02743 243231008019 HAMP domain; Region: HAMP; pfam00672 243231008020 PAS domain S-box; Region: sensory_box; TIGR00229 243231008021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008022 putative active site [active] 243231008023 heme pocket [chemical binding]; other site 243231008024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008025 dimer interface [polypeptide binding]; other site 243231008026 phosphorylation site [posttranslational modification] 243231008027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008028 ATP binding site [chemical binding]; other site 243231008029 Mg2+ binding site [ion binding]; other site 243231008030 G-X-G motif; other site 243231008031 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 243231008032 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231008033 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231008034 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 243231008035 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 243231008036 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 243231008037 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 243231008038 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 243231008039 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231008040 ligand binding site [chemical binding]; other site 243231008041 AIR carboxylase; Region: AIRC; pfam00731 243231008042 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 243231008043 active site clefts [active] 243231008044 zinc binding site [ion binding]; other site 243231008045 dimer interface [polypeptide binding]; other site 243231008046 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 243231008047 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 243231008048 Malic enzyme, N-terminal domain; Region: malic; pfam00390 243231008049 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 243231008050 NAD(P) binding pocket [chemical binding]; other site 243231008051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243231008052 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231008053 active site residue [active] 243231008054 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231008055 active site residue [active] 243231008056 Sulphur transport; Region: Sulf_transp; cl19477 243231008057 Sulphur transport; Region: Sulf_transp; cl19477 243231008058 high affinity sulphate transporter 1; Region: sulP; TIGR00815 243231008059 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 243231008060 Sulfate transporter family; Region: Sulfate_transp; pfam00916 243231008061 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 243231008062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008063 active site 243231008064 phosphorylation site [posttranslational modification] 243231008065 intermolecular recognition site; other site 243231008066 dimerization interface [polypeptide binding]; other site 243231008067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231008068 metal binding site [ion binding]; metal-binding site 243231008069 active site 243231008070 I-site; other site 243231008071 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243231008072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008073 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243231008074 putative active site [active] 243231008075 heme pocket [chemical binding]; other site 243231008076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008077 putative active site [active] 243231008078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231008079 heme pocket [chemical binding]; other site 243231008080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008081 dimer interface [polypeptide binding]; other site 243231008082 phosphorylation site [posttranslational modification] 243231008083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008084 ATP binding site [chemical binding]; other site 243231008085 Mg2+ binding site [ion binding]; other site 243231008086 G-X-G motif; other site 243231008087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231008088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008089 active site 243231008090 phosphorylation site [posttranslational modification] 243231008091 intermolecular recognition site; other site 243231008092 dimerization interface [polypeptide binding]; other site 243231008093 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243231008094 putative binding surface; other site 243231008095 active site 243231008096 Phosphate-starvation-inducible E; Region: PsiE; cl01264 243231008097 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 243231008098 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243231008099 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 243231008100 transmembrane helices; other site 243231008101 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 243231008102 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 243231008103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231008104 S-adenosylmethionine binding site [chemical binding]; other site 243231008105 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 243231008106 Protein of unknown function (DUF1475); Region: DUF1475; pfam07343 243231008107 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 243231008108 hydrophobic ligand binding site; other site 243231008109 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 243231008110 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 243231008111 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243231008112 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243231008113 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243231008114 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243231008115 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 243231008116 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243231008117 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 243231008118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243231008119 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 243231008120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231008121 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 243231008122 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 243231008123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231008124 S-adenosylmethionine binding site [chemical binding]; other site 243231008125 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 243231008126 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 243231008127 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 243231008128 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 243231008129 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243231008130 Ligand Binding Site [chemical binding]; other site 243231008131 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 243231008132 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 243231008133 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 243231008134 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 243231008135 active site 243231008136 homotetramer interface [polypeptide binding]; other site 243231008137 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 243231008138 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 243231008139 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 243231008140 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 243231008141 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231008142 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 243231008143 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 243231008144 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 243231008145 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243231008146 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231008147 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 243231008148 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 243231008149 Domain of unknown function (DUF389); Region: DUF389; pfam04087 243231008150 Protein of unknown function, DUF481; Region: DUF481; pfam04338 243231008151 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 243231008152 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 243231008153 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 243231008154 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 243231008155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243231008156 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243231008157 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243231008158 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 243231008159 Na binding site [ion binding]; other site 243231008160 Protein of unknown function, DUF485; Region: DUF485; pfam04341 243231008161 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243231008162 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243231008163 Bacterial transcriptional regulator; Region: IclR; pfam01614 243231008164 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 243231008165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 243231008166 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 243231008167 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 243231008168 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 243231008169 catalytic site [active] 243231008170 active site 243231008171 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 243231008172 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 243231008173 active site 243231008174 catalytic site [active] 243231008175 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 243231008176 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 243231008177 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 243231008178 active site 243231008179 catalytic site [active] 243231008180 trehalose synthase; Region: treS_nterm; TIGR02456 243231008181 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 243231008182 active site 243231008183 catalytic site [active] 243231008184 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 243231008185 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243231008186 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243231008187 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 243231008188 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 243231008189 Cl- selectivity filter; other site 243231008190 Cl- binding residues [ion binding]; other site 243231008191 pore gating glutamate residue; other site 243231008192 dimer interface [polypeptide binding]; other site 243231008193 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 243231008194 Cupin domain; Region: Cupin_2; cl17218 243231008195 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 243231008196 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 243231008197 NADP binding site [chemical binding]; other site 243231008198 active site 243231008199 putative substrate binding site [chemical binding]; other site 243231008200 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 243231008201 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 243231008202 NAD binding site [chemical binding]; other site 243231008203 substrate binding site [chemical binding]; other site 243231008204 homodimer interface [polypeptide binding]; other site 243231008205 active site 243231008206 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 243231008207 OstA-like protein; Region: OstA; cl00844 243231008208 Organic solvent tolerance protein; Region: OstA_C; pfam04453 243231008209 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 243231008210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243231008211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243231008212 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 243231008213 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 243231008214 substrate binding site [chemical binding]; other site 243231008215 active site 243231008216 catalytic residues [active] 243231008217 heterodimer interface [polypeptide binding]; other site 243231008218 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 243231008219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231008220 dimerization interface [polypeptide binding]; other site 243231008221 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231008222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231008223 dimer interface [polypeptide binding]; other site 243231008224 putative CheW interface [polypeptide binding]; other site 243231008225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231008226 dimer interface [polypeptide binding]; other site 243231008227 putative CheW interface [polypeptide binding]; other site 243231008228 Water Stress and Hypersensitive response; Region: WHy; smart00769 243231008229 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 243231008230 N-acetyl-D-glucosamine binding site [chemical binding]; other site 243231008231 catalytic residue [active] 243231008232 conserved nucleotide sequence; similar to other Geobacter species; GSUR0221 243231008233 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243231008234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231008235 catalytic residue [active] 243231008236 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 243231008237 ADP-ribose binding site [chemical binding]; other site 243231008238 conserved nucleotide sequence; similar to other Geobacter species; GSUR0222 243231008239 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 243231008240 active site 243231008241 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 243231008242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231008243 catalytic residue [active] 243231008244 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 243231008245 active site 243231008246 ribulose/triose binding site [chemical binding]; other site 243231008247 phosphate binding site [ion binding]; other site 243231008248 substrate (anthranilate) binding pocket [chemical binding]; other site 243231008249 product (indole) binding pocket [chemical binding]; other site 243231008250 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 243231008251 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243231008252 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243231008253 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 243231008254 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 243231008255 glutamine binding [chemical binding]; other site 243231008256 catalytic triad [active] 243231008257 anthranilate synthase component I; Provisional; Region: PRK13565 243231008258 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 243231008259 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 243231008260 GAF domain; Region: GAF_2; pfam13185 243231008261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008262 dimer interface [polypeptide binding]; other site 243231008263 phosphorylation site [posttranslational modification] 243231008264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008265 ATP binding site [chemical binding]; other site 243231008266 G-X-G motif; other site 243231008267 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 243231008268 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 243231008269 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 243231008270 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243231008271 B12 binding site [chemical binding]; other site 243231008272 Cache domain; Region: Cache_1; pfam02743 243231008273 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231008274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231008275 dimerization interface [polypeptide binding]; other site 243231008276 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231008277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008278 putative active site [active] 243231008279 heme pocket [chemical binding]; other site 243231008280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008281 dimer interface [polypeptide binding]; other site 243231008282 phosphorylation site [posttranslational modification] 243231008283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008284 ATP binding site [chemical binding]; other site 243231008285 Mg2+ binding site [ion binding]; other site 243231008286 G-X-G motif; other site 243231008287 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 243231008288 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 243231008289 ligand binding site [chemical binding]; other site 243231008290 heat shock protein 90; Provisional; Region: PRK05218 243231008291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008292 ATP binding site [chemical binding]; other site 243231008293 Mg2+ binding site [ion binding]; other site 243231008294 G-X-G motif; other site 243231008295 Hsp90 protein; Region: HSP90; pfam00183 243231008296 conserved nucleotide sequence fragment; GSUR0223 243231008297 putative transposase OrfB; Reviewed; Region: PHA02517 243231008298 HTH-like domain; Region: HTH_21; pfam13276 243231008299 Integrase core domain; Region: rve; pfam00665 243231008300 Integrase core domain; Region: rve_3; cl15866 243231008301 Transposase; Region: HTH_Tnp_1; cl17663 243231008302 conserved nucleotide sequence; similar to other Geobacter species; GSUR0224 243231008303 conserved palindrome; GSUR0225 243231008304 conserved palindrome; GSUR0226 243231008305 conserved nucleotide sequence; similar to other Geobacter species; GSUR0227 243231008306 conserved nucleotide sequence; similar to other Geobacter species; GSUR0300 243231008307 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243231008308 Sel1-like repeats; Region: SEL1; smart00671 243231008309 Sel1-like repeats; Region: SEL1; smart00671 243231008310 Sel1-like repeats; Region: SEL1; smart00671 243231008311 conserved nucleotide sequence; similar to other Geobacter species; GSUR0228 243231008312 conserved nucleotide sequence; similar to other Geobacter species; GSUR0229 243231008313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 243231008314 conserved nucleotide sequence; similar to other Geobacter species; GSUR0230 243231008315 Transposase IS200 like; Region: Y1_Tnp; cl00848 243231008316 conserved nucleotide sequence fragment (transposon-derived); GSUR0231 243231008317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 243231008318 sequence-specific DNA binding site [nucleotide binding]; other site 243231008319 salt bridge; other site 243231008320 HipA N-terminal domain; Region: Couple_hipA; cl11853 243231008321 HipA-like N-terminal domain; Region: HipA_N; pfam07805 243231008322 HipA-like C-terminal domain; Region: HipA_C; pfam07804 243231008323 conserved nucleotide sequence fragment (transposon-derived); GSUR0232 243231008324 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 243231008325 Sensory domain found in PocR; Region: PocR; pfam10114 243231008326 PAS domain S-box; Region: sensory_box; TIGR00229 243231008327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008328 putative active site [active] 243231008329 heme pocket [chemical binding]; other site 243231008330 GAF domain; Region: GAF; pfam01590 243231008331 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231008332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008333 putative active site [active] 243231008334 heme pocket [chemical binding]; other site 243231008335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008336 dimer interface [polypeptide binding]; other site 243231008337 phosphorylation site [posttranslational modification] 243231008338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008339 ATP binding site [chemical binding]; other site 243231008340 Mg2+ binding site [ion binding]; other site 243231008341 G-X-G motif; other site 243231008342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231008343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008344 active site 243231008345 phosphorylation site [posttranslational modification] 243231008346 intermolecular recognition site; other site 243231008347 dimerization interface [polypeptide binding]; other site 243231008348 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 243231008349 Protein of unknown function (DUF3620); Region: DUF3620; pfam12281 243231008350 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243231008351 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243231008352 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243231008353 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 243231008354 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243231008355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 243231008356 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243231008357 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 243231008358 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243231008359 HSP70 interaction site [polypeptide binding]; other site 243231008360 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243231008361 substrate binding site [polypeptide binding]; other site 243231008362 dimer interface [polypeptide binding]; other site 243231008363 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243231008364 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243231008365 putative dimer interface [polypeptide binding]; other site 243231008366 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243231008367 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243231008368 putative dimer interface [polypeptide binding]; other site 243231008369 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243231008370 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243231008371 putative dimer interface [polypeptide binding]; other site 243231008372 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 243231008373 homodimer interaction site [polypeptide binding]; other site 243231008374 cofactor binding site; other site 243231008375 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 243231008376 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231008377 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243231008378 Walker A/P-loop; other site 243231008379 ATP binding site [chemical binding]; other site 243231008380 Q-loop/lid; other site 243231008381 ABC transporter signature motif; other site 243231008382 Walker B; other site 243231008383 D-loop; other site 243231008384 H-loop/switch region; other site 243231008385 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 243231008386 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 243231008387 FtsX-like permease family; Region: FtsX; pfam02687 243231008388 FtsX-like permease family; Region: FtsX; pfam02687 243231008389 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 243231008390 active site 243231008391 catalytic triad [active] 243231008392 oxyanion hole [active] 243231008393 switch loop; other site 243231008394 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231008395 putative CheA interaction surface; other site 243231008396 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 243231008397 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243231008398 MgtE intracellular N domain; Region: MgtE_N; cl15244 243231008399 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 243231008400 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231008401 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231008402 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 243231008403 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 243231008404 nickel binding site [ion binding]; other site 243231008405 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231008406 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231008407 dimer interface [polypeptide binding]; other site 243231008408 putative CheW interface [polypeptide binding]; other site 243231008409 conserved nucleotide sequence; similar to other Geobacter species; GSUR0233 243231008410 conserved nucleotide sequence; similar to other Geobacter species; GSUR0234 243231008411 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 243231008412 homodimer interface [polypeptide binding]; other site 243231008413 substrate-cofactor binding pocket; other site 243231008414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231008415 catalytic residue [active] 243231008416 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 243231008417 putative FMN binding site [chemical binding]; other site 243231008418 NADPH bind site [chemical binding]; other site 243231008419 conserved nucleotide sequence; similar to other Geobacter species; GSUR0235 243231008420 pyruvate carboxylase; Reviewed; Region: PRK12999 243231008421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243231008422 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243231008423 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243231008424 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 243231008425 active site 243231008426 catalytic residues [active] 243231008427 metal binding site [ion binding]; metal-binding site 243231008428 homodimer binding site [polypeptide binding]; other site 243231008429 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 243231008430 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243231008431 carboxyltransferase (CT) interaction site; other site 243231008432 biotinylation site [posttranslational modification]; other site 243231008433 conserved nucleotide sequence; similar to other Geobacter species; GSUR0236 243231008434 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 243231008435 SurA N-terminal domain; Region: SurA_N_3; cl07813 243231008436 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 243231008437 prohibitin homologues; Region: PHB; smart00244 243231008438 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 243231008439 trimer interface [polypeptide binding]; other site 243231008440 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 243231008441 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 243231008442 dimer interface [polypeptide binding]; other site 243231008443 active site residues [active] 243231008444 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 243231008445 Cytochrome c; Region: Cytochrom_C; cl11414 243231008446 AAA domain; Region: AAA_32; pfam13654 243231008447 ATP-dependent protease Lon; Provisional; Region: PRK13765 243231008448 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243231008449 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 243231008450 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243231008451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243231008452 E3 interaction surface; other site 243231008453 lipoyl attachment site [posttranslational modification]; other site 243231008454 e3 binding domain; Region: E3_binding; pfam02817 243231008455 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243231008456 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243231008457 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243231008458 alpha subunit interface [polypeptide binding]; other site 243231008459 TPP binding site [chemical binding]; other site 243231008460 heterodimer interface [polypeptide binding]; other site 243231008461 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231008462 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 243231008463 dimer interface [polypeptide binding]; other site 243231008464 conserved nucleotide sequence; similar to other Geobacter species; GSUR0237 243231008465 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 243231008466 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 243231008467 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 243231008468 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243231008469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231008470 S-adenosylmethionine binding site [chemical binding]; other site 243231008471 conserved nucleotide sequence; similar to other Geobacter species; GSUR0238 243231008472 conserved nucleotide sequence; similar to other Geobacter species; GSUR0239 243231008473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243231008474 synthetase active site [active] 243231008475 NTP binding site [chemical binding]; other site 243231008476 metal binding site [ion binding]; metal-binding site 243231008477 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243231008478 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243231008479 tetramer interface [polypeptide binding]; other site 243231008480 TPP-binding site [chemical binding]; other site 243231008481 heterodimer interface [polypeptide binding]; other site 243231008482 phosphorylation loop region [posttranslational modification] 243231008483 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231008484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231008485 substrate binding pocket [chemical binding]; other site 243231008486 membrane-bound complex binding site; other site 243231008487 hinge residues; other site 243231008488 IncA protein; Region: IncA; pfam04156 243231008489 Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805 243231008490 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008491 dimer interface [polypeptide binding]; other site 243231008492 phosphorylation site [posttranslational modification] 243231008493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008494 ATP binding site [chemical binding]; other site 243231008495 Mg2+ binding site [ion binding]; other site 243231008496 G-X-G motif; other site 243231008497 aconitate hydratase; Validated; Region: PRK07229 243231008498 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 243231008499 substrate binding site [chemical binding]; other site 243231008500 ligand binding site [chemical binding]; other site 243231008501 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579 243231008502 substrate binding site [chemical binding]; other site 243231008503 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 243231008504 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231008505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231008506 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243231008507 conserved nucleotide sequence; similar to other Geobacter species; GSUR0240 243231008508 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243231008509 Sel1-like repeats; Region: SEL1; smart00671 243231008510 Sel1-like repeats; Region: SEL1; smart00671 243231008511 Sel1 repeat; Region: Sel1; pfam08238 243231008512 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243231008513 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 243231008514 E3 interaction surface; other site 243231008515 lipoyl attachment site [posttranslational modification]; other site 243231008516 e3 binding domain; Region: E3_binding; pfam02817 243231008517 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243231008518 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 243231008519 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 243231008520 TPP-binding site [chemical binding]; other site 243231008521 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 243231008522 dimer interface [polypeptide binding]; other site 243231008523 PYR/PP interface [polypeptide binding]; other site 243231008524 TPP binding site [chemical binding]; other site 243231008525 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243231008526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231008527 methionine sulfoxide reductase B; Provisional; Region: PRK00222 243231008528 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243231008529 metal-binding site [ion binding] 243231008530 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 243231008531 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 243231008532 metal-binding site [ion binding] 243231008533 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243231008534 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243231008535 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243231008536 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 243231008537 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 243231008538 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 243231008539 putative active site [active] 243231008540 putative metal binding site [ion binding]; other site 243231008541 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; cl00497 243231008542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243231008543 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 243231008544 YtxH-like protein; Region: YtxH; pfam12732 243231008545 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 243231008546 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 243231008547 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 243231008548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231008549 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231008550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 243231008551 heat shock protein 90; Provisional; Region: PTZ00130 243231008552 integron integrase; Region: integrase_gron; TIGR02249 243231008553 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 243231008554 Int/Topo IB signature motif; other site 243231008555 conserved nucleotide sequence; similar to other Geobacter species; GSUR0241 243231008556 conserved nucleotide sequence; similar to other Geobacter species; GSUR0242 243231008557 conserved nucleotide sequence; similar to other Geobacter species; GSUR0243 243231008558 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 243231008559 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 243231008560 putative active site [active] 243231008561 putative NTP binding site [chemical binding]; other site 243231008562 putative nucleic acid binding site [nucleotide binding]; other site 243231008563 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 243231008564 conserved nucleotide sequence; similar to other Geobacter species; GSUR0244 243231008565 conserved nucleotide sequence; similar to other Geobacter species; GSUR0245 243231008566 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 243231008567 oligomeric interface; other site 243231008568 putative active site [active] 243231008569 homodimer interface [polypeptide binding]; other site 243231008570 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 243231008571 GAF domain; Region: GAF; pfam01590 243231008572 GAF domain; Region: GAF_2; pfam13185 243231008573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231008574 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243231008575 Walker A motif; other site 243231008576 ATP binding site [chemical binding]; other site 243231008577 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 243231008578 Walker B motif; other site 243231008579 arginine finger; other site 243231008580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008581 binding surface 243231008582 TPR motif; other site 243231008583 TPR repeat; Region: TPR_11; pfam13414 243231008584 TPR repeat; Region: TPR_11; pfam13414 243231008585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008586 binding surface 243231008587 TPR motif; other site 243231008588 TPR repeat; Region: TPR_11; pfam13414 243231008589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008590 binding surface 243231008591 TPR motif; other site 243231008592 TPR repeat; Region: TPR_11; pfam13414 243231008593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231008594 S-adenosylmethionine binding site [chemical binding]; other site 243231008595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008596 binding surface 243231008597 TPR motif; other site 243231008598 TPR repeat; Region: TPR_11; pfam13414 243231008599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008600 binding surface 243231008601 TPR motif; other site 243231008602 TPR repeat; Region: TPR_11; pfam13414 243231008603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008604 binding surface 243231008605 TPR motif; other site 243231008606 Tetratricopeptide repeat; Region: TPR_19; pfam14559 243231008607 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231008608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231008609 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231008610 FeS/SAM binding site; other site 243231008611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243231008612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008613 binding surface 243231008614 TPR motif; other site 243231008615 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 243231008616 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 243231008617 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243231008618 Soluble P-type ATPase [General function prediction only]; Region: COG4087 243231008619 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 243231008620 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 243231008621 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 243231008622 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 243231008623 Ligand Binding Site [chemical binding]; other site 243231008624 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 243231008625 GAF domain; Region: GAF_3; pfam13492 243231008626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008627 dimer interface [polypeptide binding]; other site 243231008628 phosphorylation site [posttranslational modification] 243231008629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008630 ATP binding site [chemical binding]; other site 243231008631 Mg2+ binding site [ion binding]; other site 243231008632 G-X-G motif; other site 243231008633 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 243231008634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008635 active site 243231008636 phosphorylation site [posttranslational modification] 243231008637 intermolecular recognition site; other site 243231008638 dimerization interface [polypeptide binding]; other site 243231008639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231008640 DNA binding site [nucleotide binding] 243231008641 osmotic shock-responsive RNA structure; GSUR0075 243231008642 K+ potassium transporter; Region: K_trans; pfam02705 243231008643 Predicted GTPase [General function prediction only]; Region: COG2403 243231008644 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl19279 243231008645 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 243231008646 putative substrate binding site [chemical binding]; other site 243231008647 nucleotide binding site [chemical binding]; other site 243231008648 nucleotide binding site [chemical binding]; other site 243231008649 homodimer interface [polypeptide binding]; other site 243231008650 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl19054 243231008651 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243231008652 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 243231008653 active site 243231008654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231008655 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231008656 FeS/SAM binding site; other site 243231008657 conserved nucleotide sequence; similar to other Geobacter species; GSUR0246 243231008658 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 243231008659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231008660 putative substrate translocation pore; other site 243231008661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231008662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243231008663 putative substrate translocation pore; other site 243231008664 Cache domain; Region: Cache_1; pfam02743 243231008665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231008666 dimerization interface [polypeptide binding]; other site 243231008667 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231008668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008669 dimer interface [polypeptide binding]; other site 243231008670 phosphorylation site [posttranslational modification] 243231008671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008672 ATP binding site [chemical binding]; other site 243231008673 Mg2+ binding site [ion binding]; other site 243231008674 G-X-G motif; other site 243231008675 NHL repeat; Region: NHL; pfam01436 243231008676 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008677 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231008678 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008679 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008680 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008681 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008682 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008683 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008684 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008685 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008686 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008687 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231008688 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008689 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008690 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008691 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008692 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008693 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231008694 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008695 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008696 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231008697 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231008698 SurA N-terminal domain; Region: SurA_N; pfam09312 243231008699 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 243231008700 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 243231008701 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 243231008702 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 243231008703 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 243231008704 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243231008705 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 243231008706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243231008707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 243231008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243231008709 conserved nucleotide sequence; similar to other Geobacter species; GSUR0247 243231008710 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 243231008711 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 243231008712 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231008713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008714 active site 243231008715 phosphorylation site [posttranslational modification] 243231008716 intermolecular recognition site; other site 243231008717 dimerization interface [polypeptide binding]; other site 243231008718 PAS fold; Region: PAS_4; pfam08448 243231008719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231008720 Walker A motif; other site 243231008721 ATP binding site [chemical binding]; other site 243231008722 Walker B motif; other site 243231008723 arginine finger; other site 243231008724 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231008725 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 243231008726 Cache domain; Region: Cache_1; pfam02743 243231008727 Cache domain; Region: Cache_2; cl07034 243231008728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231008729 dimerization interface [polypeptide binding]; other site 243231008730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008731 ATP binding site [chemical binding]; other site 243231008732 Mg2+ binding site [ion binding]; other site 243231008733 G-X-G motif; other site 243231008734 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243231008735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008736 binding surface 243231008737 Tetratricopeptide repeat; Region: TPR_16; pfam13432 243231008738 TPR motif; other site 243231008739 TPR repeat; Region: TPR_11; pfam13414 243231008740 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231008741 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 243231008742 Ligand binding site; other site 243231008743 Putative Catalytic site; other site 243231008744 DXD motif; other site 243231008745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231008746 S-adenosylmethionine binding site [chemical binding]; other site 243231008747 CHASE4 domain; Region: CHASE4; pfam05228 243231008748 PAS domain; Region: PAS_9; pfam13426 243231008749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008750 putative active site [active] 243231008751 heme pocket [chemical binding]; other site 243231008752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231008753 metal binding site [ion binding]; metal-binding site 243231008754 active site 243231008755 I-site; other site 243231008756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 243231008757 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243231008758 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243231008759 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243231008760 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231008761 active site residue [active] 243231008762 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231008763 active site residue [active] 243231008764 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243231008765 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 243231008766 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243231008767 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 243231008768 active site residue [active] 243231008769 Rhodanese Homology Domain; Region: RHOD; smart00450 243231008770 active site residue [active] 243231008771 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 243231008772 active site residue [active] 243231008773 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 243231008774 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 243231008775 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 243231008776 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243231008777 nucleotide binding site [chemical binding]; other site 243231008778 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 243231008779 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 243231008780 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 243231008781 CPxP motif; other site 243231008782 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243231008783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231008784 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 243231008785 putative dimerization interface [polypeptide binding]; other site 243231008786 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231008787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008788 active site 243231008789 phosphorylation site [posttranslational modification] 243231008790 intermolecular recognition site; other site 243231008791 dimerization interface [polypeptide binding]; other site 243231008792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231008793 Walker A motif; other site 243231008794 ATP binding site [chemical binding]; other site 243231008795 Walker B motif; other site 243231008796 arginine finger; other site 243231008797 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231008798 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 243231008799 putative FMN binding site [chemical binding]; other site 243231008800 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243231008801 precorrin-3B synthase; Region: CobG; TIGR02435 243231008802 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 243231008803 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243231008804 FecR protein; Region: FecR; pfam04773 243231008805 Domain of unknown function (DUF243); Region: DUF243; cl11612 243231008806 elongation factor G; Reviewed; Region: PRK13351 243231008807 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243231008808 G1 box; other site 243231008809 putative GEF interaction site [polypeptide binding]; other site 243231008810 GTP/Mg2+ binding site [chemical binding]; other site 243231008811 Switch I region; other site 243231008812 G2 box; other site 243231008813 G3 box; other site 243231008814 Switch II region; other site 243231008815 G4 box; other site 243231008816 G5 box; other site 243231008817 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243231008818 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243231008819 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 243231008820 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243231008821 GTPase RsgA; Reviewed; Region: PRK01889 243231008822 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243231008823 RNA binding site [nucleotide binding]; other site 243231008824 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 243231008825 GTPase/Zn-binding domain interface [polypeptide binding]; other site 243231008826 GTP/Mg2+ binding site [chemical binding]; other site 243231008827 G4 box; other site 243231008828 G5 box; other site 243231008829 G1 box; other site 243231008830 Switch I region; other site 243231008831 G2 box; other site 243231008832 G3 box; other site 243231008833 Switch II region; other site 243231008834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231008835 dimerization interface [polypeptide binding]; other site 243231008836 PAS domain S-box; Region: sensory_box; TIGR00229 243231008837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008838 putative active site [active] 243231008839 heme pocket [chemical binding]; other site 243231008840 PAS domain; Region: PAS_8; pfam13188 243231008841 PAS domain; Region: PAS_9; pfam13426 243231008842 GAF domain; Region: GAF_3; pfam13492 243231008843 PAS domain S-box; Region: sensory_box; TIGR00229 243231008844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008845 putative active site [active] 243231008846 heme pocket [chemical binding]; other site 243231008847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008848 dimer interface [polypeptide binding]; other site 243231008849 phosphorylation site [posttranslational modification] 243231008850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008851 ATP binding site [chemical binding]; other site 243231008852 Mg2+ binding site [ion binding]; other site 243231008853 G-X-G motif; other site 243231008854 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231008855 Protein of unknown function (DUF3374); Region: DUF3374; cl11904 243231008856 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243231008857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008858 active site 243231008859 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 243231008860 phosphorylation site [posttranslational modification] 243231008861 intermolecular recognition site; other site 243231008862 dimerization interface [polypeptide binding]; other site 243231008863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231008864 putative active site [active] 243231008865 heme pocket [chemical binding]; other site 243231008866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231008867 metal binding site [ion binding]; metal-binding site 243231008868 active site 243231008869 I-site; other site 243231008870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231008871 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231008872 active site 243231008873 phosphorylation site [posttranslational modification] 243231008874 intermolecular recognition site; other site 243231008875 dimerization interface [polypeptide binding]; other site 243231008876 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 243231008877 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243231008878 arginine decarboxylase; Provisional; Region: PRK05354 243231008879 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 243231008880 dimer interface [polypeptide binding]; other site 243231008881 active site 243231008882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243231008883 catalytic residues [active] 243231008884 substrate binding site [chemical binding]; other site 243231008885 conserved nucleotide sequence; similar to other Geobacter species; GSUR1004 243231008886 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 243231008887 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 243231008888 dimer interface [polypeptide binding]; other site 243231008889 active site 243231008890 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243231008891 catalytic residues [active] 243231008892 substrate binding site [chemical binding]; other site 243231008893 conserved nucleotide sequence; similar to other Geobacter species; GSUR1005 243231008894 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 243231008895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231008896 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 243231008897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231008898 non-specific DNA binding site [nucleotide binding]; other site 243231008899 salt bridge; other site 243231008900 sequence-specific DNA binding site [nucleotide binding]; other site 243231008901 Cupin domain; Region: Cupin_2; pfam07883 243231008902 conserved nucleotide sequence; similar to other Geobacter species; GSUR0248 243231008903 conserved nucleotide sequence; similar to other Geobacter species; GSUR0249 243231008904 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 243231008905 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 243231008906 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 243231008907 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 243231008908 putative active site [active] 243231008909 putative metal binding site [ion binding]; other site 243231008910 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 243231008911 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 243231008912 catalytic residue [active] 243231008913 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 243231008914 active site 243231008915 dimer interface [polypeptide binding]; other site 243231008916 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 243231008917 Glucose inhibited division protein A; Region: GIDA; pfam01134 243231008918 conserved nucleotide sequence; similar to other Geobacter species; GSUR0250 243231008919 DNA topoisomerase I; Validated; Region: PRK06599 243231008920 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243231008921 active site 243231008922 interdomain interaction site; other site 243231008923 putative metal-binding site [ion binding]; other site 243231008924 nucleotide binding site [chemical binding]; other site 243231008925 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243231008926 domain I; other site 243231008927 DNA binding groove [nucleotide binding] 243231008928 phosphate binding site [ion binding]; other site 243231008929 domain II; other site 243231008930 domain III; other site 243231008931 nucleotide binding site [chemical binding]; other site 243231008932 catalytic site [active] 243231008933 domain IV; other site 243231008934 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243231008935 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243231008936 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 243231008937 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243231008938 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 243231008939 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 243231008940 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 243231008941 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231008942 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243231008943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231008944 TPR motif; other site 243231008945 binding surface 243231008946 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 243231008947 Ligand binding site; other site 243231008948 Putative Catalytic site; other site 243231008949 DXD motif; other site 243231008950 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 243231008951 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 243231008952 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 243231008953 putative protease; Provisional; Region: PRK15452 243231008954 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243231008955 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 243231008956 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 243231008957 putative active site [active] 243231008958 putative catalytic site [active] 243231008959 putative Zn binding site [ion binding]; other site 243231008960 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 243231008961 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 243231008962 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 243231008963 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231008964 Zn2+ binding site [ion binding]; other site 243231008965 Mg2+ binding site [ion binding]; other site 243231008966 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 243231008967 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 243231008968 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243231008969 catalytic core [active] 243231008970 hypothetical protein; Provisional; Region: PRK05170 243231008971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008972 dimer interface [polypeptide binding]; other site 243231008973 phosphorylation site [posttranslational modification] 243231008974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008975 ATP binding site [chemical binding]; other site 243231008976 Mg2+ binding site [ion binding]; other site 243231008977 G-X-G motif; other site 243231008978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231008979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231008980 dimerization interface [polypeptide binding]; other site 243231008981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231008982 dimer interface [polypeptide binding]; other site 243231008983 phosphorylation site [posttranslational modification] 243231008984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231008985 ATP binding site [chemical binding]; other site 243231008986 Mg2+ binding site [ion binding]; other site 243231008987 G-X-G motif; other site 243231008988 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 243231008989 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243231008990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231008991 FeS/SAM binding site; other site 243231008992 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 243231008993 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243231008994 Ligand Binding Site [chemical binding]; other site 243231008995 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 243231008996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231008997 catalytic residue [active] 243231008998 Transcriptional regulator; Region: Rrf2; cl17282 243231008999 Rrf2 family protein; Region: rrf2_super; TIGR00738 243231009000 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 243231009001 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 243231009002 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 243231009003 trimer interface [polypeptide binding]; other site 243231009004 active site 243231009005 substrate binding site [chemical binding]; other site 243231009006 CoA binding site [chemical binding]; other site 243231009007 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 243231009008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009009 active site 243231009010 phosphorylation site [posttranslational modification] 243231009011 intermolecular recognition site; other site 243231009012 dimerization interface [polypeptide binding]; other site 243231009013 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231009014 Zn2+ binding site [ion binding]; other site 243231009015 Mg2+ binding site [ion binding]; other site 243231009016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231009017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009018 dimer interface [polypeptide binding]; other site 243231009019 phosphorylation site [posttranslational modification] 243231009020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009021 ATP binding site [chemical binding]; other site 243231009022 Mg2+ binding site [ion binding]; other site 243231009023 G-X-G motif; other site 243231009024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231009025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009026 active site 243231009027 phosphorylation site [posttranslational modification] 243231009028 intermolecular recognition site; other site 243231009029 dimerization interface [polypeptide binding]; other site 243231009030 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 243231009031 putative binding surface; other site 243231009032 active site 243231009033 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 243231009034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231009035 Zn2+ binding site [ion binding]; other site 243231009036 Mg2+ binding site [ion binding]; other site 243231009037 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 243231009038 putative CheA interaction surface; other site 243231009039 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243231009040 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231009041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231009042 dimerization interface [polypeptide binding]; other site 243231009043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231009044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231009045 dimer interface [polypeptide binding]; other site 243231009046 putative CheW interface [polypeptide binding]; other site 243231009047 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 243231009048 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231009049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009050 active site 243231009051 phosphorylation site [posttranslational modification] 243231009052 intermolecular recognition site; other site 243231009053 dimerization interface [polypeptide binding]; other site 243231009054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231009055 Walker A motif; other site 243231009056 ATP binding site [chemical binding]; other site 243231009057 Walker B motif; other site 243231009058 Y-family of DNA polymerases; Region: PolY; cl12025 243231009059 arginine finger; other site 243231009060 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 243231009061 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 243231009062 catalytic triad [active] 243231009063 dimer interface [polypeptide binding]; other site 243231009064 conserved cis-peptide bond; other site 243231009065 Patatin-like phospholipase; Region: Patatin; pfam01734 243231009066 active site 243231009067 nucleophile elbow; other site 243231009068 Transcriptional regulators [Transcription]; Region: MarR; COG1846 243231009069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 243231009070 putative Zn2+ binding site [ion binding]; other site 243231009071 putative DNA binding site [nucleotide binding]; other site 243231009072 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 243231009073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231009074 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243231009075 conserved nucleotide sequence; similar to other Geobacter species; GSUR0296 243231009076 conserved nucleotide sequence; similar to other Geobacter species; GSUR0251 243231009077 Restriction endonuclease; Region: Mrr_cat; pfam04471 243231009078 conserved nucleotide sequence; similar to other Geobacter species; GSUR0252 243231009079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243231009080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243231009081 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243231009082 conserved nucleotide sequence; similar to other Geobacter species; GSUR0298 243231009083 conserved nucleotide sequence; similar to other Geobacter species; GSUR0253 243231009084 TIR domain; Region: TIR_2; cl17458 243231009085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 243231009086 Integrase core domain; Region: rve; pfam00665 243231009087 transposase/IS protein; Provisional; Region: PRK09183 243231009088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231009089 Walker A motif; other site 243231009090 ATP binding site [chemical binding]; other site 243231009091 Walker B motif; other site 243231009092 TIR domain; Region: TIR_2; cl17458 243231009093 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 243231009094 conserved nucleotide sequence; similar to other Geobacter species; GSUR0254 243231009095 Transposase domain (DUF772); Region: DUF772; pfam05598 243231009096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231009097 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 243231009098 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243231009099 conserved nucleotide sequence; similar to other Geobacter species; GSUR0255 243231009100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 243231009101 Transposase; Region: DEDD_Tnp_IS110; pfam01548 243231009102 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 243231009103 SEC-C motif; Region: SEC-C; pfam02810 243231009104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231009105 TPR motif; other site 243231009106 TPR repeat; Region: TPR_11; pfam13414 243231009107 binding surface 243231009108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231009109 binding surface 243231009110 TPR motif; other site 243231009111 TPR repeat; Region: TPR_11; pfam13414 243231009112 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 243231009113 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 243231009114 dimer interface [polypeptide binding]; other site 243231009115 DNA binding site [nucleotide binding] 243231009116 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 243231009117 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 243231009118 RNA binding site [nucleotide binding]; other site 243231009119 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 243231009120 RNA binding site [nucleotide binding]; other site 243231009121 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 243231009122 RNA binding site [nucleotide binding]; other site 243231009123 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243231009124 RNA binding site [nucleotide binding]; other site 243231009125 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243231009126 RNA binding site [nucleotide binding]; other site 243231009127 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 243231009128 RNA binding site [nucleotide binding]; other site 243231009129 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 243231009130 Fe-S cluster binding site [ion binding]; other site 243231009131 substrate binding site [chemical binding]; other site 243231009132 catalytic site [active] 243231009133 cytidylate kinase; Provisional; Region: cmk; PRK00023 243231009134 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243231009135 CMP-binding site; other site 243231009136 The sites determining sugar specificity; other site 243231009137 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 243231009138 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 243231009139 hinge; other site 243231009140 active site 243231009141 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 243231009142 prephenate dehydrogenase; Validated; Region: PRK08507 243231009143 Chorismate mutase type II; Region: CM_2; pfam01817 243231009144 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 243231009145 Prephenate dehydratase; Region: PDT; pfam00800 243231009146 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 243231009147 putative L-Phe binding site [chemical binding]; other site 243231009148 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 243231009149 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 243231009150 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 243231009151 Walker A motif; other site 243231009152 ATP binding site [chemical binding]; other site 243231009153 Walker B motif; other site 243231009154 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231009155 Whirly transcription factor; Region: Whirly; pfam08536 243231009156 Rubrerythrin [Energy production and conversion]; Region: COG1592 243231009157 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 243231009158 binuclear metal center [ion binding]; other site 243231009159 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 243231009160 iron binding site [ion binding]; other site 243231009161 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 243231009162 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 243231009163 DHH family; Region: DHH; pfam01368 243231009164 DHHA1 domain; Region: DHHA1; pfam02272 243231009165 TPR repeat; Region: TPR_11; pfam13414 243231009166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231009167 binding surface 243231009168 TPR motif; other site 243231009169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 243231009170 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 243231009171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243231009172 Protein export membrane protein; Region: SecD_SecF; pfam02355 243231009173 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 243231009174 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 243231009175 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 243231009176 Preprotein translocase subunit; Region: YajC; pfam02699 243231009177 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 243231009178 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 243231009179 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 243231009180 Stage II sporulation protein; Region: SpoIID; pfam08486 243231009181 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 243231009182 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231009183 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231009184 dimerization interface [polypeptide binding]; other site 243231009185 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 243231009186 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 243231009187 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243231009188 Zn2+ binding site [ion binding]; other site 243231009189 Mg2+ binding site [ion binding]; other site 243231009190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243231009191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243231009192 Walker A/P-loop; other site 243231009193 ATP binding site [chemical binding]; other site 243231009194 Q-loop/lid; other site 243231009195 ABC transporter signature motif; other site 243231009196 Walker B; other site 243231009197 D-loop; other site 243231009198 H-loop/switch region; other site 243231009199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243231009200 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 243231009201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243231009202 Walker A/P-loop; other site 243231009203 ATP binding site [chemical binding]; other site 243231009204 Q-loop/lid; other site 243231009205 ABC transporter signature motif; other site 243231009206 Walker B; other site 243231009207 D-loop; other site 243231009208 H-loop/switch region; other site 243231009209 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243231009210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243231009211 dimerization interface [polypeptide binding]; other site 243231009212 putative DNA binding site [nucleotide binding]; other site 243231009213 putative Zn2+ binding site [ion binding]; other site 243231009214 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 243231009215 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 243231009216 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 243231009217 putative RNA binding site [nucleotide binding]; other site 243231009218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231009219 S-adenosylmethionine binding site [chemical binding]; other site 243231009220 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 243231009221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231009222 S-adenosylmethionine binding site [chemical binding]; other site 243231009223 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243231009224 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231009225 TAP-like protein; Region: Abhydrolase_4; pfam08386 243231009226 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 243231009227 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 243231009228 substrate-cofactor binding pocket; other site 243231009229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231009230 catalytic residue [active] 243231009231 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 243231009232 putative protein phosphatase; Region: PHA02239 243231009233 active site 243231009234 metal binding site [ion binding]; metal-binding site 243231009235 Uncharacterized conserved protein [Function unknown]; Region: COG0432 243231009236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231009237 metal binding site [ion binding]; metal-binding site 243231009238 active site 243231009239 I-site; other site 243231009240 The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of...; Region: ML; cl00274 243231009241 Hemerythrin; Region: Hemerythrin; cd12107 243231009242 Fe binding site [ion binding]; other site 243231009243 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 243231009244 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 243231009245 active site 243231009246 catalytic site [active] 243231009247 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 243231009248 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 243231009249 NAD(P) binding site [chemical binding]; other site 243231009250 Protein of unknown function (DUF456); Region: DUF456; pfam04306 243231009251 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243231009252 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 243231009253 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 243231009254 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 243231009255 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 243231009256 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231009257 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 243231009258 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 243231009259 putative NAD(P) binding site [chemical binding]; other site 243231009260 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 243231009261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231009262 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231009263 substrate binding pocket [chemical binding]; other site 243231009264 membrane-bound complex binding site; other site 243231009265 hinge residues; other site 243231009266 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 243231009267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231009268 dimer interface [polypeptide binding]; other site 243231009269 conserved gate region; other site 243231009270 putative PBP binding loops; other site 243231009271 ABC-ATPase subunit interface; other site 243231009272 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243231009273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009274 Walker A/P-loop; other site 243231009275 ATP binding site [chemical binding]; other site 243231009276 Q-loop/lid; other site 243231009277 ABC transporter signature motif; other site 243231009278 Walker B; other site 243231009279 D-loop; other site 243231009280 H-loop/switch region; other site 243231009281 HAMP domain; Region: HAMP; pfam00672 243231009282 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231009283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231009284 dimer interface [polypeptide binding]; other site 243231009285 putative CheW interface [polypeptide binding]; other site 243231009286 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 243231009287 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 243231009288 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243231009289 TPP-binding site [chemical binding]; other site 243231009290 tetramer interface [polypeptide binding]; other site 243231009291 heterodimer interface [polypeptide binding]; other site 243231009292 phosphorylation loop region [posttranslational modification] 243231009293 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243231009294 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243231009295 alpha subunit interface [polypeptide binding]; other site 243231009296 TPP binding site [chemical binding]; other site 243231009297 heterodimer interface [polypeptide binding]; other site 243231009298 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231009299 conserved nucleotide sequence; similar to other Geobacter species; GSUR7003 243231009300 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243231009301 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243231009302 E3 interaction surface; other site 243231009303 lipoyl attachment site [posttranslational modification]; other site 243231009304 e3 binding domain; Region: E3_binding; pfam02817 243231009305 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243231009306 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 243231009307 dimer interface [polypeptide binding]; other site 243231009308 hexamer interface [polypeptide binding]; other site 243231009309 Domain 2 interface [polypeptide binding]; other site 243231009310 Domain 3 interface [polypeptide binding]; other site 243231009311 trinuclear Cu binding site [ion binding]; other site 243231009312 The second Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_2_CotA_like; cd13868 243231009313 Domain 1 interface [polypeptide binding]; other site 243231009314 Domain 3 interface [polypeptide binding]; other site 243231009315 The third Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_3_CotA_like; cd13891 243231009316 Domain 1 interface [polypeptide binding]; other site 243231009317 Type 1 (T1) Cu binding site [ion binding]; other site 243231009318 Domain 2 interface [polypeptide binding]; other site 243231009319 trinuclear Cu binding site [ion binding]; other site 243231009320 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 243231009321 Hemerythrin-like domain; Region: Hr-like; cd12108 243231009322 Fe binding site [ion binding]; other site 243231009323 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 243231009324 Protein of unknown function (DUF975); Region: DUF975; cl10504 243231009325 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 243231009326 MMPL family; Region: MMPL; cl14618 243231009327 MMPL family; Region: MMPL; cl14618 243231009328 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 243231009329 Outer membrane efflux protein; Region: OEP; pfam02321 243231009330 Outer membrane efflux protein; Region: OEP; pfam02321 243231009331 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243231009332 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231009333 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231009334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231009335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231009336 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 243231009337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009338 putative active site [active] 243231009339 heme pocket [chemical binding]; other site 243231009340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009341 dimer interface [polypeptide binding]; other site 243231009342 phosphorylation site [posttranslational modification] 243231009343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009344 ATP binding site [chemical binding]; other site 243231009345 Mg2+ binding site [ion binding]; other site 243231009346 G-X-G motif; other site 243231009347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009348 dimer interface [polypeptide binding]; other site 243231009349 phosphorylation site [posttranslational modification] 243231009350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009351 ATP binding site [chemical binding]; other site 243231009352 Mg2+ binding site [ion binding]; other site 243231009353 G-X-G motif; other site 243231009354 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231009355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243231009356 DNA binding residues [nucleotide binding] 243231009357 dimerization interface [polypeptide binding]; other site 243231009358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 243231009359 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 243231009360 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 243231009361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243231009362 conserved nucleotide sequence; similar to other Geobacter species; GSUR0256 243231009363 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 243231009364 active site 243231009365 EamA-like transporter family; Region: EamA; pfam00892 243231009366 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 243231009367 EamA-like transporter family; Region: EamA; pfam00892 243231009368 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 243231009369 EamA-like transporter family; Region: EamA; pfam00892 243231009370 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243231009371 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243231009372 putative dimer interface [polypeptide binding]; other site 243231009373 Protein of unknown function, DUF606; Region: DUF606; pfam04657 243231009374 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 243231009375 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243231009376 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231009377 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231009378 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231009379 Domain of unknown function (DUF362); Region: DUF362; pfam04015 243231009380 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 243231009381 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 243231009382 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 243231009383 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243231009384 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243231009385 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 243231009386 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243231009387 Walker A/P-loop; other site 243231009388 ATP binding site [chemical binding]; other site 243231009389 Q-loop/lid; other site 243231009390 ABC transporter signature motif; other site 243231009391 Walker B; other site 243231009392 D-loop; other site 243231009393 H-loop/switch region; other site 243231009394 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243231009395 Walker A/P-loop; other site 243231009396 ATP binding site [chemical binding]; other site 243231009397 Q-loop/lid; other site 243231009398 ABC transporter signature motif; other site 243231009399 Walker B; other site 243231009400 D-loop; other site 243231009401 H-loop/switch region; other site 243231009402 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243231009403 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 243231009404 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 243231009405 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231009406 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231009407 VacJ like lipoprotein; Region: VacJ; cl01073 243231009408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231009409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231009410 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231009411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009412 active site 243231009413 phosphorylation site [posttranslational modification] 243231009414 intermolecular recognition site; other site 243231009415 dimerization interface [polypeptide binding]; other site 243231009416 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 243231009417 Outer membrane efflux protein; Region: OEP; pfam02321 243231009418 Outer membrane efflux protein; Region: OEP; pfam02321 243231009419 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 243231009420 MMPL family; Region: MMPL; cl14618 243231009421 MMPL family; Region: MMPL; cl14618 243231009422 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 243231009423 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 243231009424 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231009425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231009426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231009427 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 243231009428 MoaE homodimer interface [polypeptide binding]; other site 243231009429 MoaD interaction [polypeptide binding]; other site 243231009430 active site residues [active] 243231009431 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231009432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231009433 dimer interface [polypeptide binding]; other site 243231009434 conserved gate region; other site 243231009435 putative PBP binding loops; other site 243231009436 ABC-ATPase subunit interface; other site 243231009437 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243231009438 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243231009439 Walker A/P-loop; other site 243231009440 ATP binding site [chemical binding]; other site 243231009441 Q-loop/lid; other site 243231009442 ABC transporter signature motif; other site 243231009443 Walker B; other site 243231009444 D-loop; other site 243231009445 H-loop/switch region; other site 243231009446 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 243231009447 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 243231009448 dimer interface [polypeptide binding]; other site 243231009449 putative functional site; other site 243231009450 putative MPT binding site; other site 243231009451 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 243231009452 trimer interface [polypeptide binding]; other site 243231009453 dimer interface [polypeptide binding]; other site 243231009454 putative active site [active] 243231009455 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 243231009456 MPT binding site; other site 243231009457 trimer interface [polypeptide binding]; other site 243231009458 conserved nucleotide sequence; similar to other Geobacter species; GSUR0257 243231009459 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 243231009460 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 243231009461 conserved nucleotide sequence; similar to other Geobacter species; GSUR0258 243231009462 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231009463 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231009464 palindrome; GSUR0259 243231009465 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 243231009466 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 243231009467 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 243231009468 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 243231009469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231009470 Protein of unknown function (DUF3812); Region: DUF3812; pfam12757 243231009471 trRNA_4; GSUR0077 243231009472 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243231009473 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243231009474 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243231009475 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243231009476 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243231009477 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 243231009478 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 243231009479 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 243231009480 Interdomain contacts; other site 243231009481 Cytokine receptor motif; other site 243231009482 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 243231009483 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 243231009484 nickel binding site [ion binding]; other site 243231009485 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 243231009486 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 243231009487 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 243231009488 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243231009489 catalytic loop [active] 243231009490 iron binding site [ion binding]; other site 243231009491 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243231009492 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231009493 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 243231009494 dimer interface [polypeptide binding]; other site 243231009495 [2Fe-2S] cluster binding site [ion binding]; other site 243231009496 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 243231009497 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 243231009498 SLBB domain; Region: SLBB; pfam10531 243231009499 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 243231009500 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 243231009501 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243231009502 putative dimer interface [polypeptide binding]; other site 243231009503 [2Fe-2S] cluster binding site [ion binding]; other site 243231009504 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 243231009505 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 243231009506 Moco binding site; other site 243231009507 metal coordination site [ion binding]; other site 243231009508 Cytochrome c7; Region: Cytochrome_C7; cl19206 243231009509 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 243231009510 conserved nucleotide sequence; similar to other Geobacter species; GSUR0260 243231009511 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231009512 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231009513 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 243231009514 conserved nucleotide sequence; similar to other Geobacter species; GSUR0261 243231009515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231009516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231009517 conserved nucleotide sequence; similar to other Geobacter species; GSUR0262 243231009518 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231009519 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243231009520 Outer membrane protein family (DUF1597); Region: DUF1597; cl19301 243231009521 conserved nucleotide sequence; similar to other Geobacter species; GSUR0263 243231009522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231009523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231009524 Cytochrome c; Region: Cytochrom_C; cl11414 243231009525 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 243231009526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231009527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243231009528 putative substrate translocation pore; other site 243231009529 Ycf46; Provisional; Region: ycf46; CHL00195 243231009530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231009531 Walker A motif; other site 243231009532 ATP binding site [chemical binding]; other site 243231009533 Walker B motif; other site 243231009534 arginine finger; other site 243231009535 Helix-turn-helix domain; Region: HTH_17; cl17695 243231009536 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 243231009537 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 243231009538 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 243231009539 Methyltransferase domain; Region: Methyltransf_26; pfam13659 243231009540 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 243231009541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231009542 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 243231009543 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231009544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009545 active site 243231009546 phosphorylation site [posttranslational modification] 243231009547 intermolecular recognition site; other site 243231009548 dimerization interface [polypeptide binding]; other site 243231009549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231009550 Walker A motif; other site 243231009551 ATP binding site [chemical binding]; other site 243231009552 Walker B motif; other site 243231009553 arginine finger; other site 243231009554 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231009555 conserved nucleotide sequence; similar to other Geobacter species; GSUR7004 243231009556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231009557 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231009558 substrate binding pocket [chemical binding]; other site 243231009559 membrane-bound complex binding site; other site 243231009560 hinge residues; other site 243231009561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231009562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009563 dimer interface [polypeptide binding]; other site 243231009564 phosphorylation site [posttranslational modification] 243231009565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009566 ATP binding site [chemical binding]; other site 243231009567 Mg2+ binding site [ion binding]; other site 243231009568 G-X-G motif; other site 243231009569 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 243231009570 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 243231009571 HSP70 interaction site [polypeptide binding]; other site 243231009572 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 243231009573 CheB methylesterase; Region: CheB_methylest; pfam01339 243231009574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009575 active site 243231009576 phosphorylation site [posttranslational modification] 243231009577 intermolecular recognition site; other site 243231009578 dimerization interface [polypeptide binding]; other site 243231009579 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 243231009580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009581 Walker A/P-loop; other site 243231009582 ATP binding site [chemical binding]; other site 243231009583 Q-loop/lid; other site 243231009584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009585 ABC transporter signature motif; other site 243231009586 Walker B; other site 243231009587 D-loop; other site 243231009588 H-loop/switch region; other site 243231009589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009590 Walker A/P-loop; other site 243231009591 ATP binding site [chemical binding]; other site 243231009592 Q-loop/lid; other site 243231009593 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 243231009594 ABC transporter signature motif; other site 243231009595 Walker B; other site 243231009596 D-loop; other site 243231009597 H-loop/switch region; other site 243231009598 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243231009599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009600 Walker A/P-loop; other site 243231009601 ATP binding site [chemical binding]; other site 243231009602 Q-loop/lid; other site 243231009603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009604 ABC transporter signature motif; other site 243231009605 Walker B; other site 243231009606 D-loop; other site 243231009607 H-loop/switch region; other site 243231009608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231009609 Walker A/P-loop; other site 243231009610 ATP binding site [chemical binding]; other site 243231009611 Q-loop/lid; other site 243231009612 ABC transporter signature motif; other site 243231009613 Walker B; other site 243231009614 D-loop; other site 243231009615 H-loop/switch region; other site 243231009616 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 243231009617 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 243231009618 TrkA-N domain; Region: TrkA_N; pfam02254 243231009619 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 243231009620 conserved nucleotide sequence; similar to other Geobacter species; GSUR0264 243231009621 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 243231009622 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231009623 glycerol kinase; Provisional; Region: glpK; PRK00047 243231009624 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 243231009625 N- and C-terminal domain interface [polypeptide binding]; other site 243231009626 active site 243231009627 MgATP binding site [chemical binding]; other site 243231009628 catalytic site [active] 243231009629 metal binding site [ion binding]; metal-binding site 243231009630 glycerol binding site [chemical binding]; other site 243231009631 homotetramer interface [polypeptide binding]; other site 243231009632 homodimer interface [polypeptide binding]; other site 243231009633 FBP binding site [chemical binding]; other site 243231009634 protein IIAGlc interface [polypeptide binding]; other site 243231009635 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 243231009636 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 243231009637 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 243231009638 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243231009639 active site 243231009640 metal binding site [ion binding]; metal-binding site 243231009641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231009642 Transposase IS200 like; Region: Y1_Tnp; pfam01797 243231009643 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243231009644 DnaA box-binding interface [nucleotide binding]; other site 243231009645 Transposase domain (DUF772); Region: DUF772; pfam05598 243231009646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 243231009647 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 243231009648 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 243231009649 active site 243231009650 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 243231009651 Lysine efflux permease [General function prediction only]; Region: COG1279 243231009652 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 243231009653 Helix-Turn-Helix DNA binding domain of putative Cfa-like transcription regulators; Region: HTH_Cfa-like_unk; cd04790 243231009654 DNA binding residues [nucleotide binding] 243231009655 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 243231009656 putative dimer interface [polypeptide binding]; other site 243231009657 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 243231009658 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231009659 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231009660 conserved nucleotide sequence; similar to other Geobacter species; GSUR0265 243231009661 multidrug efflux protein; Reviewed; Region: PRK09579 243231009662 MMPL family; Region: MMPL; cl14618 243231009663 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 243231009664 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243231009665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231009666 catalytic residue [active] 243231009667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243231009668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231009669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243231009670 dimerization interface [polypeptide binding]; other site 243231009671 OsmC-like protein; Region: OsmC; pfam02566 243231009672 PAS domain S-box; Region: sensory_box; TIGR00229 243231009673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009674 putative active site [active] 243231009675 heme pocket [chemical binding]; other site 243231009676 PAS domain S-box; Region: sensory_box; TIGR00229 243231009677 PAS domain; Region: PAS; smart00091 243231009678 PAS fold; Region: PAS_4; pfam08448 243231009679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009680 putative active site [active] 243231009681 heme pocket [chemical binding]; other site 243231009682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009683 dimer interface [polypeptide binding]; other site 243231009684 phosphorylation site [posttranslational modification] 243231009685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009686 ATP binding site [chemical binding]; other site 243231009687 Mg2+ binding site [ion binding]; other site 243231009688 G-X-G motif; other site 243231009689 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 243231009690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231009691 S-adenosylmethionine binding site [chemical binding]; other site 243231009692 conserved nucleotide sequence; similar to other Geobacter species; GSUR0266 243231009693 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 243231009694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243231009695 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231009696 Cysteine-rich domain; Region: CCG; pfam02754 243231009697 Cysteine-rich domain; Region: CCG; pfam02754 243231009698 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231009699 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231009700 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 243231009701 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 243231009702 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 243231009703 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 243231009704 Ligand binding site [chemical binding]; other site 243231009705 putative acetyltransferase; Provisional; Region: PRK03624 243231009706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 243231009707 Coenzyme A binding pocket [chemical binding]; other site 243231009708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231009709 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231009710 FeS/SAM binding site; other site 243231009711 ADP-ribosyl-[dinitrogen reductase] hydrolase; Region: dinitro_DRAG; TIGR02662 243231009712 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231009713 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 243231009714 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 243231009715 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 243231009716 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231009717 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 243231009718 bifunctional nitrogenase molybdenum-cofactor biosynthesis protein NifE/NifN; Provisional; Region: PRK14477 243231009719 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 243231009720 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 243231009721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 243231009722 Peptidase M15; Region: Peptidase_M15_3; cl01194 243231009723 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243231009724 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243231009725 metal binding site 2 [ion binding]; metal-binding site 243231009726 putative DNA binding helix; other site 243231009727 metal binding site 1 [ion binding]; metal-binding site 243231009728 dimer interface [polypeptide binding]; other site 243231009729 structural Zn2+ binding site [ion binding]; other site 243231009730 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 243231009731 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243231009732 catalytic residues [active] 243231009733 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 243231009734 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 243231009735 Rubrerythrin [Energy production and conversion]; Region: COG1592 243231009736 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 243231009737 binuclear metal center [ion binding]; other site 243231009738 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 243231009739 iron binding site [ion binding]; other site 243231009740 PAS fold; Region: PAS; pfam00989 243231009741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009742 putative active site [active] 243231009743 heme pocket [chemical binding]; other site 243231009744 PAS domain S-box; Region: sensory_box; TIGR00229 243231009745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009746 putative active site [active] 243231009747 heme pocket [chemical binding]; other site 243231009748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009749 PAS fold; Region: PAS_3; pfam08447 243231009750 putative active site [active] 243231009751 heme pocket [chemical binding]; other site 243231009752 PAS fold; Region: PAS_3; pfam08447 243231009753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009754 heme pocket [chemical binding]; other site 243231009755 putative active site [active] 243231009756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009757 dimer interface [polypeptide binding]; other site 243231009758 phosphorylation site [posttranslational modification] 243231009759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009760 ATP binding site [chemical binding]; other site 243231009761 Mg2+ binding site [ion binding]; other site 243231009762 G-X-G motif; other site 243231009763 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243231009764 PAS fold; Region: PAS_3; pfam08447 243231009765 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231009766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231009767 putative active site [active] 243231009768 heme pocket [chemical binding]; other site 243231009769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231009770 dimer interface [polypeptide binding]; other site 243231009771 phosphorylation site [posttranslational modification] 243231009772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231009773 ATP binding site [chemical binding]; other site 243231009774 Mg2+ binding site [ion binding]; other site 243231009775 G-X-G motif; other site 243231009776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009777 active site 243231009778 phosphorylation site [posttranslational modification] 243231009779 intermolecular recognition site; other site 243231009780 dimerization interface [polypeptide binding]; other site 243231009781 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 243231009782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231009783 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 243231009784 putative dimerization interface [polypeptide binding]; other site 243231009785 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 243231009786 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 243231009787 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 243231009788 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 243231009789 MoFe protein beta/alpha subunit interactions; other site 243231009790 Beta subunit P cluster binding residues; other site 243231009791 MoFe protein beta subunit/Fe protein contacts; other site 243231009792 MoFe protein dimer/ dimer interactions; other site 243231009793 conserved nucleotide sequence; similar to other Geobacter species; GSUR1006 243231009794 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 243231009795 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 243231009796 MoFe protein alpha/beta subunit interactions; other site 243231009797 Alpha subunit P cluster binding residues; other site 243231009798 FeMoco binding residues [chemical binding]; other site 243231009799 MoFe protein alpha subunit/Fe protein contacts; other site 243231009800 MoFe protein dimer/ dimer interactions; other site 243231009801 conserved nucleotide sequence; similar to other Geobacter species; GSUR1007 243231009802 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 243231009803 nitrogenase iron protein; Region: nifH; TIGR01287 243231009804 Nucleotide-binding sites [chemical binding]; other site 243231009805 Walker A motif; other site 243231009806 Switch I region of nucleotide binding site; other site 243231009807 Fe4S4 binding sites [ion binding]; other site 243231009808 Switch II region of nucleotide binding site; other site 243231009809 conserved nucleotide sequence; similar to other Geobacter species; GSUR0078 243231009810 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 243231009811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231009812 active site 243231009813 phosphorylation site [posttranslational modification] 243231009814 intermolecular recognition site; other site 243231009815 dimerization interface [polypeptide binding]; other site 243231009816 ANTAR domain; Region: ANTAR; pfam03861 243231009817 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 243231009818 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 243231009819 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231009820 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243231009821 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243231009822 Walker A/P-loop; other site 243231009823 ATP binding site [chemical binding]; other site 243231009824 Q-loop/lid; other site 243231009825 ABC transporter signature motif; other site 243231009826 Walker B; other site 243231009827 D-loop; other site 243231009828 H-loop/switch region; other site 243231009829 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 243231009830 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 243231009831 Walker A/P-loop; other site 243231009832 ATP binding site [chemical binding]; other site 243231009833 Q-loop/lid; other site 243231009834 ABC transporter signature motif; other site 243231009835 Walker B; other site 243231009836 D-loop; other site 243231009837 H-loop/switch region; other site 243231009838 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 243231009839 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 243231009840 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 243231009841 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 243231009842 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 243231009843 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 243231009844 dinuclear metal binding motif [ion binding]; other site 243231009845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231009846 active site 243231009847 I-site; other site 243231009848 metal binding site [ion binding]; metal-binding site 243231009849 photolyase PhrII; Region: phr2; TIGR00591 243231009850 DNA photolyase; Region: DNA_photolyase; pfam00875 243231009851 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 243231009852 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 243231009853 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 243231009854 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 243231009855 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243231009856 alphaNTD homodimer interface [polypeptide binding]; other site 243231009857 alphaNTD - beta interaction site [polypeptide binding]; other site 243231009858 alphaNTD - beta' interaction site [polypeptide binding]; other site 243231009859 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243231009860 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 243231009861 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243231009862 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231009863 RNA binding surface [nucleotide binding]; other site 243231009864 30S ribosomal protein S11; Validated; Region: PRK05309 243231009865 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243231009866 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 243231009867 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243231009868 active site 243231009869 adenylate kinase; Reviewed; Region: adk; PRK00279 243231009870 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243231009871 AMP-binding site [chemical binding]; other site 243231009872 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243231009873 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243231009874 SecY translocase; Region: SecY; pfam00344 243231009875 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 243231009876 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 243231009877 23S rRNA binding site [nucleotide binding]; other site 243231009878 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 243231009879 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243231009880 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243231009881 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243231009882 5S rRNA interface [nucleotide binding]; other site 243231009883 L27 interface [polypeptide binding]; other site 243231009884 23S rRNA interface [nucleotide binding]; other site 243231009885 L5 interface [polypeptide binding]; other site 243231009886 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 243231009887 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243231009888 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243231009889 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243231009890 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 243231009891 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243231009892 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243231009893 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243231009894 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243231009895 RNA binding site [nucleotide binding]; other site 243231009896 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243231009897 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243231009898 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243231009899 23S rRNA interface [nucleotide binding]; other site 243231009900 putative translocon interaction site; other site 243231009901 signal recognition particle (SRP54) interaction site; other site 243231009902 L23 interface [polypeptide binding]; other site 243231009903 trigger factor interaction site; other site 243231009904 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243231009905 23S rRNA interface [nucleotide binding]; other site 243231009906 5S rRNA interface [nucleotide binding]; other site 243231009907 putative antibiotic binding site [chemical binding]; other site 243231009908 L25 interface [polypeptide binding]; other site 243231009909 L27 interface [polypeptide binding]; other site 243231009910 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 243231009911 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243231009912 G-X-X-G motif; other site 243231009913 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243231009914 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243231009915 putative translocon binding site; other site 243231009916 protein-rRNA interface [nucleotide binding]; other site 243231009917 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243231009918 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243231009919 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243231009920 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243231009921 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 243231009922 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 243231009923 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 243231009924 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 243231009925 elongation factor Tu; Reviewed; Region: PRK00049 243231009926 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243231009927 G1 box; other site 243231009928 GEF interaction site [polypeptide binding]; other site 243231009929 GTP/Mg2+ binding site [chemical binding]; other site 243231009930 Switch I region; other site 243231009931 G2 box; other site 243231009932 G3 box; other site 243231009933 Switch II region; other site 243231009934 G4 box; other site 243231009935 G5 box; other site 243231009936 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243231009937 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243231009938 Antibiotic Binding Site [chemical binding]; other site 243231009939 elongation factor G; Reviewed; Region: PRK00007 243231009940 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243231009941 G1 box; other site 243231009942 putative GEF interaction site [polypeptide binding]; other site 243231009943 GTP/Mg2+ binding site [chemical binding]; other site 243231009944 Switch I region; other site 243231009945 G2 box; other site 243231009946 G3 box; other site 243231009947 Switch II region; other site 243231009948 G4 box; other site 243231009949 G5 box; other site 243231009950 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243231009951 Elongation Factor G, domain II; Region: EFG_II; pfam14492 243231009952 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243231009953 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243231009954 30S ribosomal protein S7; Validated; Region: PRK05302 243231009955 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243231009956 S17 interaction site [polypeptide binding]; other site 243231009957 S8 interaction site; other site 243231009958 16S rRNA interaction site [nucleotide binding]; other site 243231009959 streptomycin interaction site [chemical binding]; other site 243231009960 23S rRNA interaction site [nucleotide binding]; other site 243231009961 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243231009962 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 243231009963 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 243231009964 beta and beta' interface [polypeptide binding]; other site 243231009965 beta' and sigma factor interface [polypeptide binding]; other site 243231009966 Zn-binding [ion binding]; other site 243231009967 active site region [active] 243231009968 catalytic site [active] 243231009969 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243231009970 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 243231009971 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243231009972 G-loop; other site 243231009973 DNA binding site [nucleotide binding] 243231009974 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 243231009975 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243231009976 RPB12 interaction site [polypeptide binding]; other site 243231009977 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 243231009978 RPB1 interaction site [polypeptide binding]; other site 243231009979 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 243231009980 RPB10 interaction site [polypeptide binding]; other site 243231009981 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 243231009982 RPB11 interaction site [polypeptide binding]; other site 243231009983 RPB3 interaction site [polypeptide binding]; other site 243231009984 conserved nucleotide sequence; similar to other Geobacter species; GSUR0267 243231009985 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243231009986 core dimer interface [polypeptide binding]; other site 243231009987 peripheral dimer interface [polypeptide binding]; other site 243231009988 L10 interface [polypeptide binding]; other site 243231009989 L11 interface [polypeptide binding]; other site 243231009990 putative EF-Tu interaction site [polypeptide binding]; other site 243231009991 putative EF-G interaction site [polypeptide binding]; other site 243231009992 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243231009993 23S rRNA interface [nucleotide binding]; other site 243231009994 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243231009995 conserved nucleotide sequence; similar to other Geobacter species; GSUR0268 243231009996 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243231009997 mRNA/rRNA interface [nucleotide binding]; other site 243231009998 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243231009999 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243231010000 23S rRNA interface [nucleotide binding]; other site 243231010001 L7/L12 interface [polypeptide binding]; other site 243231010002 putative thiostrepton binding site; other site 243231010003 L25 interface [polypeptide binding]; other site 243231010004 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 243231010005 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243231010006 putative homodimer interface [polypeptide binding]; other site 243231010007 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 243231010008 heterodimer interface [polypeptide binding]; other site 243231010009 homodimer interface [polypeptide binding]; other site 243231010010 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 243231010011 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 243231010012 elongation factor Tu; Reviewed; Region: PRK00049 243231010013 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243231010014 G1 box; other site 243231010015 GEF interaction site [polypeptide binding]; other site 243231010016 GTP/Mg2+ binding site [chemical binding]; other site 243231010017 Switch I region; other site 243231010018 G2 box; other site 243231010019 G3 box; other site 243231010020 Switch II region; other site 243231010021 G4 box; other site 243231010022 G5 box; other site 243231010023 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243231010024 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243231010025 Antibiotic Binding Site [chemical binding]; other site 243231010026 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 243231010027 Ligand binding site [chemical binding]; other site 243231010028 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 243231010029 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 243231010030 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 243231010031 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 243231010032 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 243231010033 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 243231010034 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 243231010035 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243231010036 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243231010037 23S rRNA interface [nucleotide binding]; other site 243231010038 L3 interface [polypeptide binding]; other site 243231010039 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 243231010040 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243231010041 dimerization interface 3.5A [polypeptide binding]; other site 243231010042 active site 243231010043 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 243231010044 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 243231010045 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 243231010046 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 243231010047 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243231010048 ResB-like family; Region: ResB; cl09125 243231010049 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010050 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 243231010051 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010052 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010053 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010054 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231010055 heme-binding residues [chemical binding]; other site 243231010056 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231010057 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 243231010058 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 243231010059 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010060 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010061 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231010062 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243231010063 NHL repeat; Region: NHL; pfam01436 243231010064 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 243231010065 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231010066 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231010067 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231010068 heme-binding residues [chemical binding]; other site 243231010069 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243231010070 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231010071 heme-binding residues [chemical binding]; other site 243231010072 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231010073 heme-binding residues [chemical binding]; other site 243231010074 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231010075 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243231010076 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231010077 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 243231010078 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 243231010079 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231010080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231010081 FeS/SAM binding site; other site 243231010082 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243231010083 ResB-like family; Region: ResB; cl09125 243231010084 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 243231010085 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 243231010086 Sel1-like repeats; Region: SEL1; smart00671 243231010087 Sel1-like repeats; Region: SEL1; smart00671 243231010088 Sel1-like repeats; Region: SEL1; smart00671 243231010089 Sel1-like repeats; Region: SEL1; smart00671 243231010090 Sel1-like repeats; Region: SEL1; smart00671 243231010091 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243231010092 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243231010093 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243231010094 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243231010095 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 243231010096 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010097 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010098 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010099 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010100 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 243231010101 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010102 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010103 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010104 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010105 Geobacter sulfurreducens CxxxxCH...CXXCH domain; Region: GSu_C4xC__C2xCH; TIGR01904 243231010106 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 243231010107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010108 TPR motif; other site 243231010109 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 243231010110 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 243231010111 GeoRSP system SPASM domain protein; Region: GeoRSP_SPASM; TIGR04304 243231010112 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243231010113 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 243231010114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231010115 FeS/SAM binding site; other site 243231010116 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243231010117 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 243231010118 Cupin domain; Region: Cupin_2; cl17218 243231010119 Predicted permease; Region: DUF318; cl17795 243231010120 ResB-like family; Region: ResB; pfam05140 243231010121 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231010122 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 243231010123 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243231010124 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 243231010125 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 243231010126 Right handed beta helix region; Region: Beta_helix; pfam13229 243231010127 Right handed beta helix region; Region: Beta_helix; pfam13229 243231010128 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 243231010129 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010130 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH); Region: GSu_C4xC__C2xCH; pfam09698 243231010131 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231010132 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231010133 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243231010134 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 243231010135 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231010136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231010137 active site 243231010138 phosphorylation site [posttranslational modification] 243231010139 intermolecular recognition site; other site 243231010140 dimerization interface [polypeptide binding]; other site 243231010141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231010142 Walker A motif; other site 243231010143 ATP binding site [chemical binding]; other site 243231010144 Walker B motif; other site 243231010145 arginine finger; other site 243231010146 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231010147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231010148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231010149 dimerization interface [polypeptide binding]; other site 243231010150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231010151 dimer interface [polypeptide binding]; other site 243231010152 phosphorylation site [posttranslational modification] 243231010153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231010154 ATP binding site [chemical binding]; other site 243231010155 Mg2+ binding site [ion binding]; other site 243231010156 G-X-G motif; other site 243231010157 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 243231010158 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 243231010159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243231010160 PYR/PP interface [polypeptide binding]; other site 243231010161 dimer interface [polypeptide binding]; other site 243231010162 TPP binding site [chemical binding]; other site 243231010163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231010164 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243231010165 TPP-binding site [chemical binding]; other site 243231010166 dimer interface [polypeptide binding]; other site 243231010167 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 243231010168 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 243231010169 substrate binding pocket [chemical binding]; other site 243231010170 dimer interface [polypeptide binding]; other site 243231010171 inhibitor binding site; inhibition site 243231010172 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 243231010173 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 243231010174 B12 binding site [chemical binding]; other site 243231010175 cobalt ligand [ion binding]; other site 243231010176 Sporulation and spore germination; Region: Germane; pfam10646 243231010177 glutamate racemase; Provisional; Region: PRK00865 243231010178 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 243231010179 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 243231010180 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 243231010181 Predicted metallopeptidase [General function prediction only]; Region: COG4900 243231010182 Hemerythrin; Region: Hemerythrin; cd12107 243231010183 Fe binding site [ion binding]; other site 243231010184 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 243231010185 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 243231010186 Cytochrome c; Region: Cytochrom_C; cl11414 243231010187 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 243231010188 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 243231010189 heme bH binding site [chemical binding]; other site 243231010190 intrachain domain interface; other site 243231010191 Qi binding site; other site 243231010192 heme bL binding site [chemical binding]; other site 243231010193 interchain domain interface [polypeptide binding]; other site 243231010194 Qo binding site; other site 243231010195 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 243231010196 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 243231010197 iron-sulfur cluster [ion binding]; other site 243231010198 [2Fe-2S] cluster binding site [ion binding]; other site 243231010199 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231010200 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231010201 heme-binding residues [chemical binding]; other site 243231010202 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 243231010203 heme-binding residues [chemical binding]; other site 243231010204 conserved nucleotide sequence; similar to other Geobacter species; GSUR0269 243231010205 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231010206 Phosphate-selective porin O and P; Region: Porin_O_P; cl19535 243231010207 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 243231010208 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243231010209 active site residue [active] 243231010210 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 243231010211 active site residue [active] 243231010212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 243231010213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 243231010214 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 243231010215 dimerization interface [polypeptide binding]; other site 243231010216 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 243231010217 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 243231010218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231010219 dimerization interface [polypeptide binding]; other site 243231010220 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231010221 dimer interface [polypeptide binding]; other site 243231010222 putative CheW interface [polypeptide binding]; other site 243231010223 palindrome; GSUR0270 243231010224 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 243231010225 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 243231010226 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 243231010227 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 243231010228 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 243231010229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231010230 active site 243231010231 phosphorylation site [posttranslational modification] 243231010232 intermolecular recognition site; other site 243231010233 dimerization interface [polypeptide binding]; other site 243231010234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231010235 DNA binding site [nucleotide binding] 243231010236 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 243231010237 HAMP domain; Region: HAMP; pfam00672 243231010238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231010239 dimer interface [polypeptide binding]; other site 243231010240 phosphorylation site [posttranslational modification] 243231010241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231010242 ATP binding site [chemical binding]; other site 243231010243 Mg2+ binding site [ion binding]; other site 243231010244 G-X-G motif; other site 243231010245 conserved nucleotide sequence; similar to other Geobacter species; GSUR0271 243231010246 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 243231010247 Sulfatase; Region: Sulfatase; pfam00884 243231010248 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 243231010249 active site 243231010250 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 243231010251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231010252 dimer interface [polypeptide binding]; other site 243231010253 conserved gate region; other site 243231010254 putative PBP binding loops; other site 243231010255 ABC-ATPase subunit interface; other site 243231010256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231010257 dimer interface [polypeptide binding]; other site 243231010258 conserved gate region; other site 243231010259 putative PBP binding loops; other site 243231010260 ABC-ATPase subunit interface; other site 243231010261 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 243231010262 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 243231010263 Walker A/P-loop; other site 243231010264 ATP binding site [chemical binding]; other site 243231010265 Q-loop/lid; other site 243231010266 ABC transporter signature motif; other site 243231010267 Walker B; other site 243231010268 D-loop; other site 243231010269 H-loop/switch region; other site 243231010270 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 243231010271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 243231010272 putative DNA binding site [nucleotide binding]; other site 243231010273 putative Zn2+ binding site [ion binding]; other site 243231010274 Low molecular weight phosphatase family; Region: LMWPc; cd00115 243231010275 active site 243231010276 arsenical-resistance protein; Region: acr3; TIGR00832 243231010277 Predicted permeases [General function prediction only]; Region: COG0701 243231010278 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 243231010279 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243231010280 catalytic residues [active] 243231010281 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 243231010282 Cation efflux family; Region: Cation_efflux; cl00316 243231010283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243231010284 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 243231010285 Walker A/P-loop; other site 243231010286 ATP binding site [chemical binding]; other site 243231010287 Q-loop/lid; other site 243231010288 ABC transporter signature motif; other site 243231010289 Walker B; other site 243231010290 D-loop; other site 243231010291 H-loop/switch region; other site 243231010292 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 243231010293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231010294 dimer interface [polypeptide binding]; other site 243231010295 conserved gate region; other site 243231010296 putative PBP binding loops; other site 243231010297 ABC-ATPase subunit interface; other site 243231010298 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 243231010299 molybdenum transport protein ModD; Provisional; Region: PRK06096 243231010300 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 243231010301 dimerization interface [polypeptide binding]; other site 243231010302 active site 243231010303 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 243231010304 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 243231010305 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 243231010306 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 243231010307 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 243231010308 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231010309 diiron binding motif [ion binding]; other site 243231010310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231010311 PAS domain; Region: PAS_9; pfam13426 243231010312 putative active site [active] 243231010313 heme pocket [chemical binding]; other site 243231010314 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231010315 metal binding site [ion binding]; metal-binding site 243231010316 active site 243231010317 I-site; other site 243231010318 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 243231010319 YtxH-like protein; Region: YtxH; pfam12732 243231010320 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 243231010321 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 243231010322 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 243231010323 FAD binding site [chemical binding]; other site 243231010324 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 243231010325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 243231010326 DRTGG domain; Region: DRTGG; pfam07085 243231010327 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 243231010328 DHH family; Region: DHH; pfam01368 243231010329 DHHA2 domain; Region: DHHA2; pfam02833 243231010330 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 243231010331 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 243231010332 active site 243231010333 intersubunit interactions; other site 243231010334 catalytic residue [active] 243231010335 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 243231010336 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 243231010337 catalytic center binding site [active] 243231010338 ATP binding site [chemical binding]; other site 243231010339 nickel responsive regulator; Provisional; Region: PRK04460 243231010340 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 243231010341 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 243231010342 variable surface protein Vir28; Provisional; Region: PTZ00249 243231010343 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 243231010344 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 243231010345 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 243231010346 N-terminal plug; other site 243231010347 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 243231010348 ligand-binding site [chemical binding]; other site 243231010349 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 243231010350 ABC-ATPase subunit interface; other site 243231010351 dimer interface [polypeptide binding]; other site 243231010352 putative PBP binding regions; other site 243231010353 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 243231010354 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 243231010355 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 243231010356 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 243231010357 metal binding site [ion binding]; metal-binding site 243231010358 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243231010359 metal binding site 2 [ion binding]; metal-binding site 243231010360 putative DNA binding helix; other site 243231010361 metal binding site 1 [ion binding]; metal-binding site 243231010362 dimer interface [polypeptide binding]; other site 243231010363 structural Zn2+ binding site [ion binding]; other site 243231010364 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 243231010365 trimer interface [polypeptide binding]; other site 243231010366 putative Zn binding site [ion binding]; other site 243231010367 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 243231010368 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 243231010369 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231010370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231010371 homodimer interface [polypeptide binding]; other site 243231010372 catalytic residue [active] 243231010373 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 243231010374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231010375 dimerization interface [polypeptide binding]; other site 243231010376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231010377 dimer interface [polypeptide binding]; other site 243231010378 phosphorylation site [posttranslational modification] 243231010379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231010380 ATP binding site [chemical binding]; other site 243231010381 Mg2+ binding site [ion binding]; other site 243231010382 G-X-G motif; other site 243231010383 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 243231010384 active site 243231010385 SAM binding site [chemical binding]; other site 243231010386 homodimer interface [polypeptide binding]; other site 243231010387 cobyric acid synthase; Provisional; Region: PRK00784 243231010388 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231010389 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 243231010390 catalytic triad [active] 243231010391 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 243231010392 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 243231010393 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 243231010394 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 243231010395 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 243231010396 active site 243231010397 SAM binding site [chemical binding]; other site 243231010398 homodimer interface [polypeptide binding]; other site 243231010399 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 243231010400 active site 243231010401 SAM binding site [chemical binding]; other site 243231010402 homodimer interface [polypeptide binding]; other site 243231010403 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 243231010404 active site 243231010405 putative homodimer interface [polypeptide binding]; other site 243231010406 SAM binding site [chemical binding]; other site 243231010407 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243231010408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231010409 S-adenosylmethionine binding site [chemical binding]; other site 243231010410 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 243231010411 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 243231010412 Precorrin-8X methylmutase; Region: CbiC; pfam02570 243231010413 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 243231010414 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 243231010415 putative active site [active] 243231010416 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 243231010417 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243231010418 Walker A/P-loop; other site 243231010419 ATP binding site [chemical binding]; other site 243231010420 Q-loop/lid; other site 243231010421 ABC transporter signature motif; other site 243231010422 Walker B; other site 243231010423 D-loop; other site 243231010424 H-loop/switch region; other site 243231010425 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 243231010426 cobalt transport protein CbiM; Validated; Region: PRK08319 243231010427 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 243231010428 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 243231010429 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231010430 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 243231010431 catalytic triad [active] 243231010432 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 243231010433 catalytic core [active] 243231010434 cobalamin synthase; Reviewed; Region: cobS; PRK00235 243231010435 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 243231010436 putative dimer interface [polypeptide binding]; other site 243231010437 active site pocket [active] 243231010438 putative cataytic base [active] 243231010439 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 243231010440 homotrimer interface [polypeptide binding]; other site 243231010441 Walker A motif; other site 243231010442 GTP binding site [chemical binding]; other site 243231010443 Walker B motif; other site 243231010444 Predicted GTPase [General function prediction only]; Region: COG0218 243231010445 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 243231010446 G1 box; other site 243231010447 GTP/Mg2+ binding site [chemical binding]; other site 243231010448 Switch I region; other site 243231010449 G2 box; other site 243231010450 G3 box; other site 243231010451 Switch II region; other site 243231010452 G4 box; other site 243231010453 G5 box; other site 243231010454 HDOD domain; Region: HDOD; pfam08668 243231010455 FlaG protein; Region: FlaG; pfam03646 243231010456 M6 family metalloprotease domain; Region: M6dom_TIGR03296 243231010457 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010458 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010459 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010460 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010461 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010462 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010463 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 243231010464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231010465 S-adenosylmethionine binding site [chemical binding]; other site 243231010466 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243231010467 tetramer interface [polypeptide binding]; other site 243231010468 TPP-binding site [chemical binding]; other site 243231010469 heterodimer interface [polypeptide binding]; other site 243231010470 phosphorylation loop region [posttranslational modification] 243231010471 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243231010472 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 243231010473 PYR/PP interface [polypeptide binding]; other site 243231010474 dimer interface [polypeptide binding]; other site 243231010475 TPP binding site [chemical binding]; other site 243231010476 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231010477 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243231010478 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 243231010479 E3 interaction surface; other site 243231010480 lipoyl attachment site [posttranslational modification]; other site 243231010481 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 243231010482 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 243231010483 putative trimer interface [polypeptide binding]; other site 243231010484 putative CoA binding site [chemical binding]; other site 243231010485 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 243231010486 inhibitor-cofactor binding pocket; inhibition site 243231010487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231010488 catalytic residue [active] 243231010489 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 243231010490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243231010491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 243231010492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231010493 TPR repeat; Region: TPR_11; pfam13414 243231010494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010495 TPR motif; other site 243231010496 binding surface 243231010497 Methyltransferase domain; Region: Methyltransf_31; pfam13847 243231010498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231010499 S-adenosylmethionine binding site [chemical binding]; other site 243231010500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243231010501 active site 243231010502 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 243231010503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231010504 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 243231010505 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243231010506 Probable Catalytic site; other site 243231010507 metal-binding site 243231010508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 243231010509 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 243231010510 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 243231010511 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 243231010512 Probable Catalytic site; other site 243231010513 metal-binding site 243231010514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010515 binding surface 243231010516 TPR repeat; Region: TPR_11; pfam13414 243231010517 TPR motif; other site 243231010518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010519 binding surface 243231010520 TPR motif; other site 243231010521 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 243231010522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010523 binding surface 243231010524 TPR motif; other site 243231010525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010526 binding surface 243231010527 TPR motif; other site 243231010528 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 243231010529 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 243231010530 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 243231010531 putative active site [active] 243231010532 Flagellar protein (FlbD); Region: FlbD; pfam06289 243231010533 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 243231010534 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 243231010535 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 243231010536 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 243231010537 ligand binding site [chemical binding]; other site 243231010538 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 243231010539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231010540 putative substrate translocation pore; other site 243231010541 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243231010542 putative acyl-acceptor binding pocket; other site 243231010543 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 243231010544 acyl-activating enzyme (AAE) consensus motif; other site 243231010545 putative AMP binding site [chemical binding]; other site 243231010546 active site 243231010547 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243231010548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231010549 Walker A motif; other site 243231010550 ATP binding site [chemical binding]; other site 243231010551 Walker B motif; other site 243231010552 arginine finger; other site 243231010553 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 243231010554 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 243231010555 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 243231010556 PilZ domain; Region: PilZ; pfam07238 243231010557 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 243231010558 Flagellar protein FliS; Region: FliS; cl00654 243231010559 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 243231010560 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 243231010561 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 243231010562 flagellin; Reviewed; Region: PRK08869 243231010563 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243231010564 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243231010565 flagellar assembly protein FliW; Provisional; Region: PRK13285 243231010566 Global regulator protein family; Region: CsrA; pfam02599 243231010567 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 243231010568 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 243231010569 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 243231010570 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 243231010571 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243231010572 Tho complex subunit 7; Region: THOC7; pfam05615 243231010573 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243231010574 FlgN protein; Region: FlgN; pfam05130 243231010575 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 243231010576 Rod binding protein; Region: Rod-binding; pfam10135 243231010577 palindrome; GSUR0272 243231010578 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 243231010579 conserved nucleotide sequence; similar to other Geobacter species; GSUR1008 243231010580 Flagellar L-ring protein; Region: FlgH; pfam02107 243231010581 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 243231010582 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 243231010583 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243231010584 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 243231010585 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 243231010586 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 243231010587 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 243231010588 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 243231010589 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 243231010590 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 243231010591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243231010592 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243231010593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243231010594 DNA binding residues [nucleotide binding] 243231010595 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 243231010596 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243231010597 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 243231010598 P-loop; other site 243231010599 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 243231010600 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 243231010601 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 243231010602 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 243231010603 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 243231010604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243231010605 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243231010606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231010607 NAD(P) binding site [chemical binding]; other site 243231010608 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 243231010609 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 243231010610 FAD binding pocket [chemical binding]; other site 243231010611 FAD binding motif [chemical binding]; other site 243231010612 phosphate binding motif [ion binding]; other site 243231010613 beta-alpha-beta structure motif; other site 243231010614 NAD binding pocket [chemical binding]; other site 243231010615 Iron coordination center [ion binding]; other site 243231010616 Radical SAM superfamily; Region: Radical_SAM; pfam04055 243231010617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231010618 FeS/SAM binding site; other site 243231010619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 243231010620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 243231010621 WHG domain; Region: WHG; pfam13305 243231010622 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 243231010623 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 243231010624 Active site cavity [active] 243231010625 catalytic acid [active] 243231010626 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 243231010627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231010628 FeS/SAM binding site; other site 243231010629 conserved nucleotide sequence; similar to other Geobacter species; GSUR0273 243231010630 cell division protein FtsZ; Validated; Region: PRK09330 243231010631 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 243231010632 nucleotide binding site [chemical binding]; other site 243231010633 SulA interaction site; other site 243231010634 cell division protein FtsA; Region: ftsA; TIGR01174 243231010635 Cell division protein FtsA; Region: FtsA; smart00842 243231010636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 243231010637 nucleotide binding site [chemical binding]; other site 243231010638 Cell division protein FtsA; Region: FtsA; pfam14450 243231010639 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 243231010640 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 243231010641 Cell division protein FtsQ; Region: FtsQ; pfam03799 243231010642 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 243231010643 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 243231010644 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243231010645 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 243231010646 FAD binding domain; Region: FAD_binding_4; pfam01565 243231010647 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 243231010648 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 243231010649 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243231010650 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243231010651 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243231010652 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 243231010653 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 243231010654 active site 243231010655 homodimer interface [polypeptide binding]; other site 243231010656 cell division protein FtsW; Region: ftsW; TIGR02614 243231010657 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 243231010658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 243231010659 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243231010660 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243231010661 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243231010662 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 243231010663 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 243231010664 Mg++ binding site [ion binding]; other site 243231010665 putative catalytic motif [active] 243231010666 putative substrate binding site [chemical binding]; other site 243231010667 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 243231010668 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243231010669 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243231010670 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243231010671 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 243231010672 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 243231010673 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 243231010674 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 243231010675 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 243231010676 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 243231010677 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243231010678 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 243231010679 cell division protein FtsL; Region: ftsL_broad; TIGR02209 243231010680 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 243231010681 cell division protein MraZ; Reviewed; Region: PRK00326 243231010682 MraZ protein; Region: MraZ; pfam02381 243231010683 MraZ protein; Region: MraZ; pfam02381 243231010684 conserved nucleotide sequence; similar to other Geobacter species; GSUR0274 243231010685 Transposase; Region: HTH_Tnp_1; cl17663 243231010686 putative transposase OrfB; Reviewed; Region: PHA02517 243231010687 HTH-like domain; Region: HTH_21; pfam13276 243231010688 Integrase core domain; Region: rve; pfam00665 243231010689 Integrase core domain; Region: rve_3; cl15866 243231010690 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 243231010691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 243231010692 conserved nucleotide sequence; similar to other Geobacter species; GSUR0275 243231010693 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 243231010694 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 243231010695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 243231010696 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 243231010697 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 243231010698 putative deacylase active site [active] 243231010699 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 243231010700 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 243231010701 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 243231010702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243231010703 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243231010704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243231010705 DNA binding residues [nucleotide binding] 243231010706 DNA primase; Validated; Region: dnaG; PRK05667 243231010707 CHC2 zinc finger; Region: zf-CHC2; pfam01807 243231010708 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243231010709 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243231010710 active site 243231010711 metal binding site [ion binding]; metal-binding site 243231010712 interdomain interaction site; other site 243231010713 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 243231010714 Colicin V production protein; Region: Colicin_V; pfam02674 243231010715 Yqey-like protein; Region: YqeY; pfam09424 243231010716 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 243231010717 conserved nucleotide sequence; similar to other Geobacter species; GSUR0276 243231010718 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 243231010719 metal binding site [ion binding]; metal-binding site 243231010720 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 243231010721 substrate binding site [chemical binding]; other site 243231010722 glutamase interaction surface [polypeptide binding]; other site 243231010723 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 243231010724 catalytic residues [active] 243231010725 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 243231010726 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 243231010727 putative active site [active] 243231010728 oxyanion strand; other site 243231010729 catalytic triad [active] 243231010730 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 243231010731 putative active site pocket [active] 243231010732 4-fold oligomerization interface [polypeptide binding]; other site 243231010733 metal binding residues [ion binding]; metal-binding site 243231010734 3-fold/trimer interface [polypeptide binding]; other site 243231010735 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 243231010736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 243231010737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231010738 homodimer interface [polypeptide binding]; other site 243231010739 catalytic residue [active] 243231010740 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 243231010741 histidinol dehydrogenase; Region: hisD; TIGR00069 243231010742 NAD binding site [chemical binding]; other site 243231010743 dimerization interface [polypeptide binding]; other site 243231010744 product binding site; other site 243231010745 substrate binding site [chemical binding]; other site 243231010746 zinc binding site [ion binding]; other site 243231010747 catalytic residues [active] 243231010748 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 243231010749 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 243231010750 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 243231010751 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 243231010752 hinge; other site 243231010753 active site 243231010754 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 243231010755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231010756 S-adenosylmethionine binding site [chemical binding]; other site 243231010757 peptide chain release factor 1; Validated; Region: prfA; PRK00591 243231010758 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243231010759 RF-1 domain; Region: RF-1; pfam00472 243231010760 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 243231010761 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 243231010762 conserved nucleotide sequence; similar to other Geobacter species; GSUR0299 243231010763 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 243231010764 transcription termination factor Rho; Provisional; Region: rho; PRK09376 243231010765 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 243231010766 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 243231010767 RNA binding site [nucleotide binding]; other site 243231010768 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 243231010769 multimer interface [polypeptide binding]; other site 243231010770 Walker A motif; other site 243231010771 ATP binding site [chemical binding]; other site 243231010772 Walker B motif; other site 243231010773 Transcriptional regulator [Transcription]; Region: IclR; COG1414 243231010774 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 243231010775 Bacterial transcriptional regulator; Region: IclR; pfam01614 243231010776 integron integrase; Region: integrase_gron; TIGR02249 243231010777 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 243231010778 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 243231010779 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 243231010780 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 243231010781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231010782 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 243231010783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010784 binding surface 243231010785 TPR motif; other site 243231010786 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243231010787 putative acyl-acceptor binding pocket; other site 243231010788 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243231010789 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243231010790 dimer interface [polypeptide binding]; other site 243231010791 ssDNA binding site [nucleotide binding]; other site 243231010792 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243231010793 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 243231010794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231010795 active site 243231010796 phosphorylation site [posttranslational modification] 243231010797 intermolecular recognition site; other site 243231010798 dimerization interface [polypeptide binding]; other site 243231010799 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 243231010800 DNA binding site [nucleotide binding] 243231010801 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 243231010802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 243231010803 dimerization interface [polypeptide binding]; other site 243231010804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231010805 dimer interface [polypeptide binding]; other site 243231010806 phosphorylation site [posttranslational modification] 243231010807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231010808 ATP binding site [chemical binding]; other site 243231010809 Mg2+ binding site [ion binding]; other site 243231010810 G-X-G motif; other site 243231010811 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 243231010812 dimer interface [polypeptide binding]; other site 243231010813 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 243231010814 EF-hand domain pair; Region: EF-hand_7; pfam13499 243231010815 Ca2+ binding site [ion binding]; other site 243231010816 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 243231010817 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 243231010818 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 243231010819 Ferredoxin [Energy production and conversion]; Region: COG1146 243231010820 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231010821 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 243231010822 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 243231010823 putative NAD(P) binding site [chemical binding]; other site 243231010824 putative substrate binding site [chemical binding]; other site 243231010825 catalytic Zn binding site [ion binding]; other site 243231010826 structural Zn binding site [ion binding]; other site 243231010827 dimer interface [polypeptide binding]; other site 243231010828 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 243231010829 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 243231010830 active site 243231010831 catalytic tetrad [active] 243231010832 conserved nucleotide sequence; similar to other Geobacter species; GSUR0277 243231010833 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 243231010834 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243231010835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243231010836 conserved nucleotide sequence; similar to other Geobacter species; GSUR0278 243231010837 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 243231010838 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 243231010839 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 243231010840 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 243231010841 histone-like DNA-binding protein HU; Region: HU; cd13831 243231010842 dimer interface [polypeptide binding]; other site 243231010843 DNA binding site [nucleotide binding] 243231010844 conserved nucleotide sequence; similar to other Geobacter species; GSUR0279 243231010845 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 243231010846 Transglycosylase; Region: Transgly; pfam00912 243231010847 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 243231010848 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 243231010849 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 243231010850 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 243231010851 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243231010852 active site 243231010853 HIGH motif; other site 243231010854 KMSKS motif; other site 243231010855 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 243231010856 tRNA binding surface [nucleotide binding]; other site 243231010857 anticodon binding site; other site 243231010858 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243231010859 Cytochrome c7; Region: Cytochrome_C7; pfam14522 243231010860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231010861 active site 243231010862 phosphorylation site [posttranslational modification] 243231010863 intermolecular recognition site; other site 243231010864 dimerization interface [polypeptide binding]; other site 243231010865 PAS fold; Region: PAS_4; pfam08448 243231010866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231010867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231010868 dimer interface [polypeptide binding]; other site 243231010869 phosphorylation site [posttranslational modification] 243231010870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231010871 ATP binding site [chemical binding]; other site 243231010872 Mg2+ binding site [ion binding]; other site 243231010873 G-X-G motif; other site 243231010874 Protein of unknown function, DUF399; Region: DUF399; pfam04187 243231010875 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 243231010876 Zn binding site [ion binding]; other site 243231010877 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 243231010878 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 243231010879 conserved nucleotide sequence; similar to other Geobacter species; GSUR0081 243231010880 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243231010881 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 243231010882 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 243231010883 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 243231010884 putative RNA binding site [nucleotide binding]; other site 243231010885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231010886 S-adenosylmethionine binding site [chemical binding]; other site 243231010887 MOSC domain; Region: MOSC; pfam03473 243231010888 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 243231010889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231010890 FeS/SAM binding site; other site 243231010891 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 243231010892 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional; Region: PRK14489 243231010893 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 243231010894 GTP binding site; other site 243231010895 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 243231010896 Walker A motif; other site 243231010897 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 243231010898 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243231010899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231010900 dimer interface [polypeptide binding]; other site 243231010901 phosphorylation site [posttranslational modification] 243231010902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231010903 ATP binding site [chemical binding]; other site 243231010904 Mg2+ binding site [ion binding]; other site 243231010905 G-X-G motif; other site 243231010906 HPP family; Region: HPP; pfam04982 243231010907 PAS domain S-box; Region: sensory_box; TIGR00229 243231010908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231010909 putative active site [active] 243231010910 heme pocket [chemical binding]; other site 243231010911 4Fe-4S binding domain; Region: Fer4_5; pfam12801 243231010912 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 243231010913 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 243231010914 Cytochrome c552; Region: Cytochrom_C552; pfam02335 243231010915 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 243231010916 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 243231010917 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231010918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231010919 dimer interface [polypeptide binding]; other site 243231010920 putative CheW interface [polypeptide binding]; other site 243231010921 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 243231010922 Putative lysophospholipase; Region: Hydrolase_4; cl19140 243231010923 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 243231010924 cysteine synthase; Region: PLN02565 243231010925 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 243231010926 dimer interface [polypeptide binding]; other site 243231010927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231010928 catalytic residue [active] 243231010929 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 243231010930 putative active site [active] 243231010931 putative CoA binding site [chemical binding]; other site 243231010932 nudix motif; other site 243231010933 metal binding site [ion binding]; metal-binding site 243231010934 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 243231010935 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243231010936 probable active site [active] 243231010937 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243231010938 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 243231010939 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 243231010940 tetramer interface [polypeptide binding]; other site 243231010941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231010942 catalytic residue [active] 243231010943 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 243231010944 catalytic residues [active] 243231010945 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 243231010946 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 243231010947 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 243231010948 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 243231010949 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 243231010950 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 243231010951 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 243231010952 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243231010953 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 243231010954 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231010955 PGAP1-like protein; Region: PGAP1; pfam07819 243231010956 Protein of unknown function (DUF770); Region: DUF770; pfam05591 243231010957 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 243231010958 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 243231010959 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 243231010960 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231010961 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 243231010962 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 243231010963 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 243231010964 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 243231010965 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 243231010966 conserved hypothetical protein; Region: TIGR02270 243231010967 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 243231010968 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243231010969 active site 243231010970 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 243231010971 active site 243231010972 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 243231010973 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 243231010974 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 243231010975 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243231010976 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243231010977 Rubredoxin [Energy production and conversion]; Region: COG1773 243231010978 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 243231010979 iron binding site [ion binding]; other site 243231010980 Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326 243231010981 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 243231010982 TPR repeat; Region: TPR_11; pfam13414 243231010983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010984 TPR motif; other site 243231010985 binding surface 243231010986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010987 binding surface 243231010988 TPR motif; other site 243231010989 TPR repeat; Region: TPR_11; pfam13414 243231010990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010991 binding surface 243231010992 TPR motif; other site 243231010993 TPR repeat; Region: TPR_11; pfam13414 243231010994 TPR repeat; Region: TPR_11; pfam13414 243231010995 TPR repeat; Region: TPR_11; pfam13414 243231010996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231010997 binding surface 243231010998 TPR motif; other site 243231010999 TPR repeat; Region: TPR_11; pfam13414 243231011000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 243231011001 binding surface 243231011002 TPR motif; other site 243231011003 TPR repeat; Region: TPR_11; pfam13414 243231011004 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 243231011005 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 243231011006 putative dimer interface [polypeptide binding]; other site 243231011007 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243231011008 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 243231011009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231011010 Walker A motif; other site 243231011011 ATP binding site [chemical binding]; other site 243231011012 Walker B motif; other site 243231011013 arginine finger; other site 243231011014 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243231011015 thiamine monophosphate kinase; Provisional; Region: PRK05731 243231011016 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 243231011017 ATP binding site [chemical binding]; other site 243231011018 dimerization interface [polypeptide binding]; other site 243231011019 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 243231011020 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 243231011021 HAMP domain; Region: HAMP; pfam00672 243231011022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 243231011023 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 243231011024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 243231011025 dimer interface [polypeptide binding]; other site 243231011026 putative CheW interface [polypeptide binding]; other site 243231011027 CheW-like domain; Region: CheW; pfam01584 243231011028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011029 active site 243231011030 phosphorylation site [posttranslational modification] 243231011031 intermolecular recognition site; other site 243231011032 dimerization interface [polypeptide binding]; other site 243231011033 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 243231011034 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 243231011035 putative binding surface; other site 243231011036 active site 243231011037 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 243231011038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011039 ATP binding site [chemical binding]; other site 243231011040 Mg2+ binding site [ion binding]; other site 243231011041 G-X-G motif; other site 243231011042 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 243231011043 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 243231011044 CheC-like family; Region: CheC; pfam04509 243231011045 Chemotaxis phosphatase CheX; Region: CheX; cl15816 243231011046 CheD chemotactic sensory transduction; Region: CheD; cl00810 243231011047 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 243231011048 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 243231011049 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 243231011050 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 243231011051 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 243231011052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231011053 FeS/SAM binding site; other site 243231011054 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 243231011055 phosphoglyceromutase; Provisional; Region: PRK05434 243231011056 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 243231011057 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 243231011058 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243231011059 active site 243231011060 (T/H)XGH motif; other site 243231011061 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 243231011062 putative catalytic cysteine [active] 243231011063 conserved nucleotide sequence; similar to other Geobacter species; GSUR0280 243231011064 gamma-glutamyl kinase; Provisional; Region: PRK05429 243231011065 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 243231011066 nucleotide binding site [chemical binding]; other site 243231011067 homotetrameric interface [polypeptide binding]; other site 243231011068 putative phosphate binding site [ion binding]; other site 243231011069 putative allosteric binding site; other site 243231011070 PUA domain; Region: PUA; pfam01472 243231011071 GTPase CgtA; Reviewed; Region: obgE; PRK12299 243231011072 GTP1/OBG; Region: GTP1_OBG; pfam01018 243231011073 Obg GTPase; Region: Obg; cd01898 243231011074 G1 box; other site 243231011075 GTP/Mg2+ binding site [chemical binding]; other site 243231011076 Switch I region; other site 243231011077 G2 box; other site 243231011078 G3 box; other site 243231011079 Switch II region; other site 243231011080 G4 box; other site 243231011081 G5 box; other site 243231011082 PilZ domain; Region: PilZ; pfam07238 243231011083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011084 ATP binding site [chemical binding]; other site 243231011085 G-X-G motif; other site 243231011086 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231011087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011088 active site 243231011089 phosphorylation site [posttranslational modification] 243231011090 intermolecular recognition site; other site 243231011091 dimerization interface [polypeptide binding]; other site 243231011092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231011093 Walker A motif; other site 243231011094 ATP binding site [chemical binding]; other site 243231011095 Walker B motif; other site 243231011096 arginine finger; other site 243231011097 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231011098 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231011099 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 243231011100 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231011101 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231011102 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231011103 doubled CXXCH domain; Region: paired_CXXCH_1; TIGR01905 243231011104 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231011105 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 243231011106 Subtilase family; Region: Peptidase_S8; pfam00082 243231011107 active site 243231011108 catalytic triad [active] 243231011109 Uncharacterized conserved protein [Function unknown]; Region: COG1572 243231011110 CARDB; Region: CARDB; pfam07705 243231011111 Uncharacterized conserved protein [Function unknown]; Region: COG1572 243231011112 CARDB; Region: CARDB; pfam07705 243231011113 CARDB; Region: CARDB; pfam07705 243231011114 CARDB; Region: CARDB; pfam07705 243231011115 CARDB; Region: CARDB; pfam07705 243231011116 CARDB; Region: CARDB; pfam07705 243231011117 CARDB; Region: CARDB; pfam07705 243231011118 CARDB; Region: CARDB; pfam07705 243231011119 CARDB; Region: CARDB; pfam07705 243231011120 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231011121 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243231011122 Major royal jelly protein; Region: MRJP; pfam03022 243231011123 Beta-propeller repeat; Region: SBBP; pfam06739 243231011124 Cwf15/Cwc15 cell cycle control protein; Region: Cwf_Cwc_15; pfam04889 243231011125 Cytochrome c7; Region: Cytochrome_C7; cl19206 243231011126 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 243231011127 Uncharacterized conserved protein [Function unknown]; Region: COG3391 243231011128 SdiA-regulated; Region: SdiA-regulated; cl19046 243231011129 NHL repeat; Region: NHL; pfam01436 243231011130 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231011131 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 243231011132 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 243231011133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011134 active site 243231011135 phosphorylation site [posttranslational modification] 243231011136 intermolecular recognition site; other site 243231011137 dimerization interface [polypeptide binding]; other site 243231011138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 243231011139 DNA binding residues [nucleotide binding] 243231011140 dimerization interface [polypeptide binding]; other site 243231011141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231011142 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 243231011143 putative active site [active] 243231011144 heme pocket [chemical binding]; other site 243231011145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 243231011146 Histidine kinase; Region: HisKA_3; pfam07730 243231011147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011148 ATP binding site [chemical binding]; other site 243231011149 Mg2+ binding site [ion binding]; other site 243231011150 G-X-G motif; other site 243231011151 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 243231011152 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 243231011153 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 243231011154 iron-sulfur cluster [ion binding]; other site 243231011155 [2Fe-2S] cluster binding site [ion binding]; other site 243231011156 ribonuclease G; Provisional; Region: PRK11712 243231011157 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 243231011158 homodimer interface [polypeptide binding]; other site 243231011159 oligonucleotide binding site [chemical binding]; other site 243231011160 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 243231011161 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 243231011162 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 243231011163 B12 binding site [chemical binding]; other site 243231011164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231011165 FeS/SAM binding site; other site 243231011166 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 243231011167 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 243231011168 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 243231011169 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 243231011170 DNA polymerase type-B family; Region: POLBc; smart00486 243231011171 active site 243231011172 catalytic site [active] 243231011173 substrate binding site [chemical binding]; other site 243231011174 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 243231011175 active site 243231011176 metal-binding site 243231011177 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243231011178 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 243231011179 dimer interface [polypeptide binding]; other site 243231011180 decamer (pentamer of dimers) interface [polypeptide binding]; other site 243231011181 catalytic triad [active] 243231011182 peroxidatic and resolving cysteines [active] 243231011183 Ferredoxin [Energy production and conversion]; Region: COG1146 243231011184 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 243231011185 hypothetical protein; Provisional; Region: PRK10410 243231011186 poly(A) polymerase; Region: pcnB; TIGR01942 243231011187 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 243231011188 active site 243231011189 NTP binding site [chemical binding]; other site 243231011190 metal binding triad [ion binding]; metal-binding site 243231011191 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 243231011192 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 243231011193 conserved nucleotide sequence; similar to other Geobacter species; GSUR4003 243231011194 Protein of unknown function (DUF523); Region: DUF523; pfam04463 243231011195 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 243231011196 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243231011197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231011198 dimer interface [polypeptide binding]; other site 243231011199 phosphorylation site [posttranslational modification] 243231011200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011201 ATP binding site [chemical binding]; other site 243231011202 Mg2+ binding site [ion binding]; other site 243231011203 G-X-G motif; other site 243231011204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011205 active site 243231011206 phosphorylation site [posttranslational modification] 243231011207 intermolecular recognition site; other site 243231011208 dimerization interface [polypeptide binding]; other site 243231011209 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 243231011210 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 243231011211 active site 243231011212 Substrate binding site; other site 243231011213 Mg++ binding site; other site 243231011214 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 243231011215 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 243231011216 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 243231011217 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 243231011218 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 243231011219 putative active site [active] 243231011220 catalytic site [active] 243231011221 ADP-glucose phosphorylase; Region: PLN02643 243231011222 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 243231011223 dimer interface [polypeptide binding]; other site 243231011224 active site 243231011225 glycogen synthase; Provisional; Region: glgA; PRK00654 243231011226 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 243231011227 ADP-binding pocket [chemical binding]; other site 243231011228 homodimer interface [polypeptide binding]; other site 243231011229 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243231011230 Copper resistance protein D; Region: CopD; pfam05425 243231011231 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 243231011232 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 243231011233 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 243231011234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231011235 catalytic residue [active] 243231011236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 243231011237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011238 active site 243231011239 phosphorylation site [posttranslational modification] 243231011240 intermolecular recognition site; other site 243231011241 dimerization interface [polypeptide binding]; other site 243231011242 excinuclease ABC subunit B; Provisional; Region: PRK05298 243231011243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243231011244 ATP binding site [chemical binding]; other site 243231011245 putative Mg++ binding site [ion binding]; other site 243231011246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243231011247 nucleotide binding region [chemical binding]; other site 243231011248 ATP-binding site [chemical binding]; other site 243231011249 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243231011250 UvrB/uvrC motif; Region: UVR; pfam02151 243231011251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011252 active site 243231011253 phosphorylation site [posttranslational modification] 243231011254 intermolecular recognition site; other site 243231011255 dimerization interface [polypeptide binding]; other site 243231011256 PilZ domain; Region: PilZ; pfam07238 243231011257 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 243231011258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231011259 putative substrate translocation pore; other site 243231011260 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 243231011261 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 243231011262 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 243231011263 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 243231011264 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243231011265 Part of AAA domain; Region: AAA_19; pfam13245 243231011266 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243231011267 Virus attachment protein p12 family; Region: P12; pfam12669 243231011268 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 243231011269 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 243231011270 G1 box; other site 243231011271 GTP/Mg2+ binding site [chemical binding]; other site 243231011272 Switch I region; other site 243231011273 G2 box; other site 243231011274 G3 box; other site 243231011275 Switch II region; other site 243231011276 G4 box; other site 243231011277 G5 box; other site 243231011278 Nucleoside recognition; Region: Gate; pfam07670 243231011279 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 243231011280 Nucleoside recognition; Region: Gate; pfam07670 243231011281 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 243231011282 FeoA domain; Region: FeoA; pfam04023 243231011283 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 243231011284 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 243231011285 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 243231011286 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 243231011287 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231011288 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 243231011289 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 243231011290 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 243231011291 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 243231011292 conserved nucleotide sequence; similar to other Geobacter species; GSUR0281 243231011293 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 243231011294 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243231011295 GIY-YIG motif/motif A; other site 243231011296 active site 243231011297 catalytic site [active] 243231011298 putative DNA binding site [nucleotide binding]; other site 243231011299 metal binding site [ion binding]; metal-binding site 243231011300 UvrB/uvrC motif; Region: UVR; pfam02151 243231011301 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243231011302 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 243231011303 DNA binding site [nucleotide binding] 243231011304 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 243231011305 catalytic residues [active] 243231011306 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243231011307 catalytic residues [active] 243231011308 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 243231011309 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 243231011310 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 243231011311 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 243231011312 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 243231011313 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 243231011314 tRNA; other site 243231011315 putative tRNA binding site [nucleotide binding]; other site 243231011316 putative NADP binding site [chemical binding]; other site 243231011317 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 243231011318 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 243231011319 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 243231011320 domain interfaces; other site 243231011321 active site 243231011322 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 243231011323 active site 243231011324 SAM binding site [chemical binding]; other site 243231011325 homodimer interface [polypeptide binding]; other site 243231011326 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 243231011327 active site 243231011328 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 243231011329 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243231011330 active site 243231011331 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 243231011332 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 243231011333 putative ATP binding site [chemical binding]; other site 243231011334 putative substrate interface [chemical binding]; other site 243231011335 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231011336 diiron binding motif [ion binding]; other site 243231011337 Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723 243231011338 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 243231011339 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 243231011340 conserved nucleotide sequence; similar to other Geobacter species; GSUR0282 243231011341 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 243231011342 metal binding site 2 [ion binding]; metal-binding site 243231011343 putative DNA binding helix; other site 243231011344 metal binding site 1 [ion binding]; metal-binding site 243231011345 dimer interface [polypeptide binding]; other site 243231011346 structural Zn2+ binding site [ion binding]; other site 243231011347 Rubredoxin [Energy production and conversion]; Region: COG1773 243231011348 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 243231011349 iron binding site [ion binding]; other site 243231011350 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 243231011351 diiron binding motif [ion binding]; other site 243231011352 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 243231011353 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 243231011354 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 243231011355 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 243231011356 FAD binding domain; Region: FAD_binding_4; pfam01565 243231011357 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 243231011358 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 243231011359 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 243231011360 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231011361 Cysteine-rich domain; Region: CCG; pfam02754 243231011362 Cysteine-rich domain; Region: CCG; pfam02754 243231011363 conserved nucleotide sequence; similar to other Geobacter species; GSUR0283 243231011364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 243231011365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231011366 non-specific DNA binding site [nucleotide binding]; other site 243231011367 salt bridge; other site 243231011368 sequence-specific DNA binding site [nucleotide binding]; other site 243231011369 Cupin domain; Region: Cupin_2; pfam07883 243231011370 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 243231011371 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 243231011372 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 243231011373 biotin carboxylase; Validated; Region: PRK08462 243231011374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 243231011375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243231011376 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 243231011377 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 243231011378 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 243231011379 carboxyltransferase (CT) interaction site; other site 243231011380 biotinylation site [posttranslational modification]; other site 243231011381 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 243231011382 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243231011383 TMP-binding site; other site 243231011384 ATP-binding site [chemical binding]; other site 243231011385 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 243231011386 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 243231011387 dimer interface [polypeptide binding]; other site 243231011388 substrate binding site [chemical binding]; other site 243231011389 metal binding site [ion binding]; metal-binding site 243231011390 conserved nucleotide sequence; similar to other Geobacter species; GSUR0284 243231011391 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 243231011392 Alginate export; Region: Alginate_exp; pfam13372 243231011393 seryl-tRNA synthetase; Provisional; Region: PRK05431 243231011394 conserved nucleotide sequence; similar to other Geobacter species; GSUR0285 243231011395 conserved nucleotide sequence; similar to other Geobacter species; GSUR0286 243231011396 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 243231011397 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 243231011398 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243231011399 dimer interface [polypeptide binding]; other site 243231011400 motif 1; other site 243231011401 active site 243231011402 motif 2; other site 243231011403 motif 3; other site 243231011404 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 243231011405 anticodon binding site; other site 243231011406 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 243231011407 GDP-binding site [chemical binding]; other site 243231011408 ACT binding site; other site 243231011409 IMP binding site; other site 243231011410 trRNA_5; GSUR0082 243231011411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231011412 Walker A motif; other site 243231011413 ATP binding site [chemical binding]; other site 243231011414 Walker B motif; other site 243231011415 arginine finger; other site 243231011416 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 243231011417 heme-binding site [chemical binding]; other site 243231011418 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 243231011419 Ferrochelatase; Region: Ferrochelatase; pfam00762 243231011420 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 243231011421 C-terminal domain interface [polypeptide binding]; other site 243231011422 active site 243231011423 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 243231011424 active site 243231011425 N-terminal domain interface [polypeptide binding]; other site 243231011426 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 243231011427 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 243231011428 active site 243231011429 palindrome; GSUR0287 243231011430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243231011431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 243231011432 putative substrate translocation pore; other site 243231011433 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 243231011434 ResB-like family; Region: ResB; cl09125 243231011435 ResB-like family; Region: ResB; cl09125 243231011436 Uncharacterized conserved protein [Function unknown]; Region: COG5316 243231011437 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 243231011438 substrate binding site [chemical binding]; other site 243231011439 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 243231011440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231011441 S-adenosylmethionine binding site [chemical binding]; other site 243231011442 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243231011443 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 243231011444 active site 243231011445 substrate binding site [chemical binding]; other site 243231011446 metal binding site [ion binding]; metal-binding site 243231011447 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 243231011448 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 243231011449 Cl binding site [ion binding]; other site 243231011450 oligomer interface [polypeptide binding]; other site 243231011451 polyphosphate kinase; Provisional; Region: PRK05443 243231011452 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 243231011453 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 243231011454 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243231011455 putative active site [active] 243231011456 catalytic site [active] 243231011457 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 243231011458 putative active site [active] 243231011459 catalytic site [active] 243231011460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 243231011461 non-specific DNA binding site [nucleotide binding]; other site 243231011462 Predicted transcriptional regulator [Transcription]; Region: COG2932 243231011463 salt bridge; other site 243231011464 sequence-specific DNA binding site [nucleotide binding]; other site 243231011465 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 243231011466 Catalytic site [active] 243231011467 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243231011468 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243231011469 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243231011470 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243231011471 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 243231011472 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 243231011473 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 243231011474 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 243231011475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231011476 FeS/SAM binding site; other site 243231011477 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 243231011478 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 243231011479 active site 243231011480 FMN binding site [chemical binding]; other site 243231011481 substrate binding site [chemical binding]; other site 243231011482 putative catalytic residue [active] 243231011483 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 243231011484 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 243231011485 domain interfaces; other site 243231011486 active site 243231011487 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 243231011488 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 243231011489 Cytochrome c; Region: Cytochrom_C; cl11414 243231011490 Protein of unknown function (DUF507); Region: DUF507; cl01112 243231011491 Protein of unknown function (DUF507); Region: DUF507; cl01112 243231011492 conserved nucleotide sequence; similar to other Geobacter species; GSUR0288 243231011493 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243231011494 oligomerisation interface [polypeptide binding]; other site 243231011495 mobile loop; other site 243231011496 roof hairpin; other site 243231011497 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 243231011498 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243231011499 ring oligomerisation interface [polypeptide binding]; other site 243231011500 ATP/Mg binding site [chemical binding]; other site 243231011501 stacking interactions; other site 243231011502 hinge regions; other site 243231011503 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 243231011504 PrkA AAA domain; Region: AAA_PrkA; smart00763 243231011505 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 243231011506 hypothetical protein; Provisional; Region: PRK05325 243231011507 SpoVR like protein; Region: SpoVR; cl19504 243231011508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 243231011509 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 243231011510 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 243231011511 K+ potassium transporter; Region: K_trans; pfam02705 243231011512 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 243231011513 putative protease; Provisional; Region: PRK15452 243231011514 Collagenase; Region: DUF3656; pfam12392 243231011515 conserved nucleotide sequence; similar to other Geobacter species; GSUR0289 243231011516 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 243231011517 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 243231011518 dimerization interface [polypeptide binding]; other site 243231011519 domain crossover interface; other site 243231011520 redox-dependent activation switch; other site 243231011521 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 243231011522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231011523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231011524 dimer interface [polypeptide binding]; other site 243231011525 phosphorylation site [posttranslational modification] 243231011526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011527 ATP binding site [chemical binding]; other site 243231011528 Mg2+ binding site [ion binding]; other site 243231011529 G-X-G motif; other site 243231011530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011531 active site 243231011532 phosphorylation site [posttranslational modification] 243231011533 intermolecular recognition site; other site 243231011534 dimerization interface [polypeptide binding]; other site 243231011535 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231011536 metal binding site [ion binding]; metal-binding site 243231011537 active site 243231011538 I-site; other site 243231011539 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 243231011540 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243231011541 RNA binding surface [nucleotide binding]; other site 243231011542 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243231011543 active site 243231011544 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 243231011545 dimer interface [polypeptide binding]; other site 243231011546 ADP-ribose binding site [chemical binding]; other site 243231011547 active site 243231011548 nudix motif; other site 243231011549 metal binding site [ion binding]; metal-binding site 243231011550 HAMP domain; Region: HAMP; pfam00672 243231011551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231011552 metal binding site [ion binding]; metal-binding site 243231011553 active site 243231011554 I-site; other site 243231011555 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243231011556 PAS domain S-box; Region: sensory_box; TIGR00229 243231011557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231011558 putative active site [active] 243231011559 heme pocket [chemical binding]; other site 243231011560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231011561 dimer interface [polypeptide binding]; other site 243231011562 phosphorylation site [posttranslational modification] 243231011563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011564 ATP binding site [chemical binding]; other site 243231011565 Mg2+ binding site [ion binding]; other site 243231011566 G-X-G motif; other site 243231011567 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 243231011568 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 243231011569 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 243231011570 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 243231011571 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 243231011572 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 243231011573 conserved nucleotide sequence; similar to other Geobacter species; GSUR0290 243231011574 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231011575 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 243231011576 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 243231011577 Putative Fe-S cluster; Region: FeS; cl17515 243231011578 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 243231011579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231011580 Walker A motif; other site 243231011581 ATP binding site [chemical binding]; other site 243231011582 Walker B motif; other site 243231011583 arginine finger; other site 243231011584 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231011585 conserved nucleotide sequence; similar to other Geobacter species; GSUR0291 243231011586 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 243231011587 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 243231011588 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243231011589 active site 243231011590 HIGH motif; other site 243231011591 KMSKS motif; other site 243231011592 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 243231011593 tRNA binding surface [nucleotide binding]; other site 243231011594 anticodon binding site; other site 243231011595 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 243231011596 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 243231011597 active site 243231011598 HIGH motif; other site 243231011599 KMSKS motif; other site 243231011600 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 243231011601 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243231011602 homotrimer interaction site [polypeptide binding]; other site 243231011603 zinc binding site [ion binding]; other site 243231011604 CDP-binding sites; other site 243231011605 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 243231011606 substrate binding site; other site 243231011607 dimer interface; other site 243231011608 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 243231011609 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 243231011610 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 243231011611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243231011612 catalytic residue [active] 243231011613 Transcriptional regulators [Transcription]; Region: GntR; COG1802 243231011614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243231011615 DNA-binding site [nucleotide binding]; DNA binding site 243231011616 FCD domain; Region: FCD; pfam07729 243231011617 conserved nucleotide sequence; similar to other Geobacter species; GSUR0292 243231011618 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 243231011619 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 243231011620 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 243231011621 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 243231011622 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 243231011623 putative active site [active] 243231011624 catalytic site [active] 243231011625 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 243231011626 putative active site [active] 243231011627 catalytic site [active] 243231011628 16S rRNA methyltransferase B; Provisional; Region: PRK14902 243231011629 NusB family; Region: NusB; pfam01029 243231011630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231011631 S-adenosylmethionine binding site [chemical binding]; other site 243231011632 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243231011633 substrate binding site [chemical binding]; other site 243231011634 hexamer interface [polypeptide binding]; other site 243231011635 metal binding site [ion binding]; metal-binding site 243231011636 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 243231011637 putative active site [active] 243231011638 putative CoA binding site [chemical binding]; other site 243231011639 nudix motif; other site 243231011640 metal binding site [ion binding]; metal-binding site 243231011641 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 243231011642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011643 active site 243231011644 phosphorylation site [posttranslational modification] 243231011645 intermolecular recognition site; other site 243231011646 dimerization interface [polypeptide binding]; other site 243231011647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 243231011648 metal binding site [ion binding]; metal-binding site 243231011649 active site 243231011650 I-site; other site 243231011651 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 243231011652 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 243231011653 minor groove reading motif; other site 243231011654 helix-hairpin-helix signature motif; other site 243231011655 substrate binding pocket [chemical binding]; other site 243231011656 active site 243231011657 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 243231011658 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243231011659 metal binding triad; other site 243231011660 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 243231011661 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 243231011662 metal binding triad; other site 243231011663 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 243231011664 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 243231011665 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 243231011666 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243231011667 GatB domain; Region: GatB_Yqey; smart00845 243231011668 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 243231011669 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 243231011670 conserved nucleotide sequence; similar to other Geobacter species; GSUR0293 243231011671 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 243231011672 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 243231011673 putative active site [active] 243231011674 catalytic site [active] 243231011675 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 243231011676 putative active site [active] 243231011677 catalytic site [active] 243231011678 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 243231011679 active site 243231011680 substrate-binding site [chemical binding]; other site 243231011681 metal-binding site [ion binding] 243231011682 GTP binding site [chemical binding]; other site 243231011683 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 243231011684 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 243231011685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243231011686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 243231011687 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243231011688 EamA-like transporter family; Region: EamA; pfam00892 243231011689 EamA-like transporter family; Region: EamA; pfam00892 243231011690 FecR protein; Region: FecR; pfam04773 243231011691 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243231011692 EamA-like transporter family; Region: EamA; pfam00892 243231011693 EamA-like transporter family; Region: EamA; pfam00892 243231011694 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 243231011695 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 243231011696 Walker A/P-loop; other site 243231011697 ATP binding site [chemical binding]; other site 243231011698 Q-loop/lid; other site 243231011699 ABC transporter signature motif; other site 243231011700 Walker B; other site 243231011701 D-loop; other site 243231011702 H-loop/switch region; other site 243231011703 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 243231011704 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 243231011705 Walker A/P-loop; other site 243231011706 ATP binding site [chemical binding]; other site 243231011707 Q-loop/lid; other site 243231011708 ABC transporter signature motif; other site 243231011709 Walker B; other site 243231011710 D-loop; other site 243231011711 H-loop/switch region; other site 243231011712 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 243231011713 TM-ABC transporter signature motif; other site 243231011714 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 243231011715 TM-ABC transporter signature motif; other site 243231011716 Proline dehydrogenase; Region: Pro_dh; pfam01619 243231011717 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 243231011718 Glutamate binding site [chemical binding]; other site 243231011719 homodimer interface [polypeptide binding]; other site 243231011720 NAD binding site [chemical binding]; other site 243231011721 catalytic residues [active] 243231011722 conserved nucleotide sequence; similar to other Geobacter species; GSUR0294 243231011723 Transcriptional regulators [Transcription]; Region: FadR; COG2186 243231011724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243231011725 DNA-binding site [nucleotide binding]; DNA binding site 243231011726 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 243231011727 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 243231011728 Outer membrane efflux protein; Region: OEP; pfam02321 243231011729 Outer membrane efflux protein; Region: OEP; pfam02321 243231011730 YtkA-like; Region: YtkA; pfam13115 243231011731 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 243231011732 HlyD family secretion protein; Region: HlyD_3; pfam13437 243231011733 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 243231011734 MMPL family; Region: MMPL; cl14618 243231011735 MMPL family; Region: MMPL; cl14618 243231011736 palindrome; GSUR0295 243231011737 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 243231011738 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 243231011739 putative ligand binding site [chemical binding]; other site 243231011740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 243231011741 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 243231011742 Walker A/P-loop; other site 243231011743 ATP binding site [chemical binding]; other site 243231011744 Q-loop/lid; other site 243231011745 ABC transporter signature motif; other site 243231011746 Walker B; other site 243231011747 D-loop; other site 243231011748 H-loop/switch region; other site 243231011749 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243231011750 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 243231011751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243231011752 dimer interface [polypeptide binding]; other site 243231011753 conserved gate region; other site 243231011754 putative PBP binding loops; other site 243231011755 ABC-ATPase subunit interface; other site 243231011756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 243231011757 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 243231011758 substrate binding pocket [chemical binding]; other site 243231011759 membrane-bound complex binding site; other site 243231011760 hinge residues; other site 243231011761 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 243231011762 EamA-like transporter family; Region: EamA; pfam00892 243231011763 EamA-like transporter family; Region: EamA; pfam00892 243231011764 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 243231011765 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 243231011766 tetramer interface [polypeptide binding]; other site 243231011767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 243231011768 catalytic residue [active] 243231011769 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 243231011770 Part of AAA domain; Region: AAA_19; pfam13245 243231011771 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 243231011772 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 243231011773 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 243231011774 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 243231011775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231011776 FeS/SAM binding site; other site 243231011777 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 243231011778 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 243231011779 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 243231011780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 243231011781 active site 243231011782 phosphorylation site [posttranslational modification] 243231011783 intermolecular recognition site; other site 243231011784 dimerization interface [polypeptide binding]; other site 243231011785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243231011786 Walker A motif; other site 243231011787 ATP binding site [chemical binding]; other site 243231011788 Walker B motif; other site 243231011789 arginine finger; other site 243231011790 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 243231011791 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 243231011792 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 243231011793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231011794 dimer interface [polypeptide binding]; other site 243231011795 phosphorylation site [posttranslational modification] 243231011796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011797 ATP binding site [chemical binding]; other site 243231011798 Mg2+ binding site [ion binding]; other site 243231011799 G-X-G motif; other site 243231011800 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 243231011801 putative acyl-acceptor binding pocket; other site 243231011802 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 243231011803 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 243231011804 ligand binding site [chemical binding]; other site 243231011805 flexible hinge region; other site 243231011806 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 243231011807 putative switch regulator; other site 243231011808 non-specific DNA interactions [nucleotide binding]; other site 243231011809 DNA binding site [nucleotide binding] 243231011810 sequence specific DNA binding site [nucleotide binding]; other site 243231011811 putative cAMP binding site [chemical binding]; other site 243231011812 DTW domain; Region: DTW; cl01221 243231011813 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 243231011814 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243231011815 TPP-binding site [chemical binding]; other site 243231011816 dimer interface [polypeptide binding]; other site 243231011817 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243231011818 PYR/PP interface [polypeptide binding]; other site 243231011819 dimer interface [polypeptide binding]; other site 243231011820 TPP binding site [chemical binding]; other site 243231011821 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243231011822 mercuric reductase; Region: MerA; TIGR02053 243231011823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 243231011824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243231011825 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 243231011826 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 243231011827 conserved nucleotide sequence; similar to other Geobacter species; GSUR7005 243231011828 hypothetical protein; Provisional; Region: PRK09272 243231011829 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 243231011830 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 243231011831 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231011832 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 243231011833 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231011834 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 243231011835 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 243231011836 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 243231011837 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 243231011838 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265 243231011839 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 243231011840 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 243231011841 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 243231011842 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 243231011843 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 243231011844 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 243231011845 PAS domain S-box; Region: sensory_box; TIGR00229 243231011846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 243231011847 putative active site [active] 243231011848 heme pocket [chemical binding]; other site 243231011849 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 243231011850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 243231011851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 243231011852 dimer interface [polypeptide binding]; other site 243231011853 phosphorylation site [posttranslational modification] 243231011854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243231011855 ATP binding site [chemical binding]; other site 243231011856 Mg2+ binding site [ion binding]; other site 243231011857 G-X-G motif; other site 243231011858 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 243231011859 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 243231011860 PhnA protein; Region: PhnA; pfam03831 243231011861 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 243231011862 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 243231011863 catalytic loop [active] 243231011864 iron binding site [ion binding]; other site 243231011865 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 243231011866 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 243231011867 molybdopterin cofactor binding site; other site 243231011868 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 243231011869 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 243231011870 SLBB domain; Region: SLBB; pfam10531 243231011871 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 243231011872 Uncharacterized conserved protein [Function unknown]; Region: COG3189 243231011873 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 243231011874 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 243231011875 putative dimer interface [polypeptide binding]; other site 243231011876 [2Fe-2S] cluster binding site [ion binding]; other site 243231011877 NADH dehydrogenase subunit B; Validated; Region: PRK06411 243231011878 trifunctional NADH dehydrogenase I subunit B/C/D; Provisional; Region: PRK13292 243231011879 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 243231011880 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 243231011881 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 243231011882 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243231011883 catalytic residues [active] 243231011884 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 243231011885 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 243231011886 catalytic triad [active] 243231011887 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 243231011888 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 243231011889 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 243231011890 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 243231011891 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 243231011892 active site 243231011893 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 243231011894 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 243231011895 active site 243231011896 FMN binding site [chemical binding]; other site 243231011897 substrate binding site [chemical binding]; other site 243231011898 3Fe-4S cluster binding site [ion binding]; other site 243231011899 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 243231011900 domain_subunit interface; other site 243231011901 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243231011902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243231011903 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 243231011904 SlyX; Region: SlyX; pfam04102 243231011905 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 243231011906 substrate binding site [chemical binding]; other site 243231011907 active site 243231011908 conserved nucleotide sequence; similar to other Geobacter species; GSUR1009 243231011909 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 243231011910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 243231011911 FeS/SAM binding site; other site 243231011912 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 243231011913 ABC-2 type transporter; Region: ABC2_membrane; cl17235 243231011914 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 243231011915 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243231011916 active site 243231011917 catalytic residues [active] 243231011918 metal binding site [ion binding]; metal-binding site 243231011919 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 243231011920 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 243231011921 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 243231011922 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243231011923 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 243231011924 active site 243231011925 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 243231011926 active site 243231011927 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 243231011928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243231011929 S-adenosylmethionine binding site [chemical binding]; other site 243231011930 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 243231011931 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 243231011932 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 243231011933 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 243231011934 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243231011935 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243231011936 G1 box; other site 243231011937 GTP/Mg2+ binding site [chemical binding]; other site 243231011938 Switch I region; other site 243231011939 G2 box; other site 243231011940 Switch II region; other site 243231011941 G3 box; other site 243231011942 G4 box; other site 243231011943 G5 box; other site 243231011944 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 243231011945 membrane protein insertase; Provisional; Region: PRK01318 243231011946 YidC periplasmic domain; Region: YidC_periplas; pfam14849 243231011947 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 243231011948 Haemolytic domain; Region: Haemolytic; pfam01809 243231011949 Ribonuclease P; Region: Ribonuclease_P; cl00457 243231011950 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399