-- dump date 20140619_101423 -- class Genbank::misc_feature -- table misc_feature_note -- id note 420246000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 420246000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 420246000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000004 Walker A motif; other site 420246000005 ATP binding site [chemical binding]; other site 420246000006 Walker B motif; other site 420246000007 arginine finger; other site 420246000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 420246000009 DnaA box-binding interface [nucleotide binding]; other site 420246000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 420246000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 420246000012 putative DNA binding surface [nucleotide binding]; other site 420246000013 dimer interface [polypeptide binding]; other site 420246000014 beta-clamp/clamp loader binding surface; other site 420246000015 beta-clamp/translesion DNA polymerase binding surface; other site 420246000016 S4 domain; Region: S4_2; cl17325 420246000017 recombination protein F; Reviewed; Region: recF; PRK00064 420246000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 420246000019 Walker A/P-loop; other site 420246000020 ATP binding site [chemical binding]; other site 420246000021 Q-loop/lid; other site 420246000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246000023 ABC transporter signature motif; other site 420246000024 Walker B; other site 420246000025 D-loop; other site 420246000026 H-loop/switch region; other site 420246000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 420246000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246000029 Mg2+ binding site [ion binding]; other site 420246000030 G-X-G motif; other site 420246000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 420246000032 anchoring element; other site 420246000033 dimer interface [polypeptide binding]; other site 420246000034 ATP binding site [chemical binding]; other site 420246000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 420246000036 active site 420246000037 putative metal-binding site [ion binding]; other site 420246000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 420246000039 DNA gyrase subunit A; Validated; Region: PRK05560 420246000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 420246000041 CAP-like domain; other site 420246000042 active site 420246000043 primary dimer interface [polypeptide binding]; other site 420246000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 420246000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246000052 Zn2+ binding site [ion binding]; other site 420246000053 Mg2+ binding site [ion binding]; other site 420246000054 YaaC-like Protein; Region: YaaC; pfam14175 420246000055 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 420246000056 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 420246000057 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 420246000058 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 420246000059 active site 420246000060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 420246000061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 420246000062 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 420246000063 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 420246000064 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 420246000065 active site 420246000066 multimer interface [polypeptide binding]; other site 420246000067 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 420246000068 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 420246000069 predicted active site [active] 420246000070 catalytic triad [active] 420246000071 seryl-tRNA synthetase; Provisional; Region: PRK05431 420246000072 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 420246000073 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 420246000074 dimer interface [polypeptide binding]; other site 420246000075 active site 420246000076 motif 1; other site 420246000077 motif 2; other site 420246000078 motif 3; other site 420246000079 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 420246000080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246000081 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246000082 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 420246000083 active site 420246000084 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 420246000085 nucleoside/Zn binding site; other site 420246000086 dimer interface [polypeptide binding]; other site 420246000087 catalytic motif [active] 420246000088 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 420246000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000090 Walker A motif; other site 420246000091 ATP binding site [chemical binding]; other site 420246000092 Walker B motif; other site 420246000093 arginine finger; other site 420246000094 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 420246000095 hypothetical protein; Validated; Region: PRK00153 420246000096 recombination protein RecR; Reviewed; Region: recR; PRK00076 420246000097 RecR protein; Region: RecR; pfam02132 420246000098 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 420246000099 putative active site [active] 420246000100 putative metal-binding site [ion binding]; other site 420246000101 tetramer interface [polypeptide binding]; other site 420246000102 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 420246000103 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 420246000104 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 420246000105 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 420246000106 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 420246000107 homodimer interface [polypeptide binding]; other site 420246000108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246000109 catalytic residue [active] 420246000110 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 420246000111 thymidylate kinase; Validated; Region: tmk; PRK00698 420246000112 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 420246000113 TMP-binding site; other site 420246000114 ATP-binding site [chemical binding]; other site 420246000115 DNA polymerase III subunit delta'; Validated; Region: PRK08058 420246000116 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 420246000117 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 420246000118 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 420246000119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246000120 S-adenosylmethionine binding site [chemical binding]; other site 420246000121 Predicted methyltransferases [General function prediction only]; Region: COG0313 420246000122 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 420246000123 putative SAM binding site [chemical binding]; other site 420246000124 putative homodimer interface [polypeptide binding]; other site 420246000125 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 420246000126 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 420246000127 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 420246000128 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 420246000129 active site 420246000130 HIGH motif; other site 420246000131 KMSKS motif; other site 420246000132 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 420246000133 tRNA binding surface [nucleotide binding]; other site 420246000134 anticodon binding site; other site 420246000135 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 420246000136 dimer interface [polypeptide binding]; other site 420246000137 putative tRNA-binding site [nucleotide binding]; other site 420246000138 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 420246000139 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 420246000140 active site 420246000141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 420246000142 Domain of unknown function (DUF348); Region: DUF348; pfam03990 420246000143 Domain of unknown function (DUF348); Region: DUF348; pfam03990 420246000144 Domain of unknown function (DUF348); Region: DUF348; pfam03990 420246000145 G5 domain; Region: G5; pfam07501 420246000146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 420246000147 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 420246000148 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 420246000149 putative active site [active] 420246000150 putative metal binding site [ion binding]; other site 420246000151 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 420246000152 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 420246000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246000154 S-adenosylmethionine binding site [chemical binding]; other site 420246000155 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 420246000156 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 420246000157 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 420246000158 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 420246000159 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 420246000160 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 420246000161 pur operon repressor; Provisional; Region: PRK09213 420246000162 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 420246000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246000164 active site 420246000165 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 420246000166 homotrimer interaction site [polypeptide binding]; other site 420246000167 putative active site [active] 420246000168 regulatory protein SpoVG; Reviewed; Region: PRK13259 420246000169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 420246000170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 420246000171 Substrate binding site; other site 420246000172 Mg++ binding site; other site 420246000173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 420246000174 active site 420246000175 substrate binding site [chemical binding]; other site 420246000176 CoA binding site [chemical binding]; other site 420246000177 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 420246000178 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 420246000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246000180 active site 420246000181 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 420246000182 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 420246000183 5S rRNA interface [nucleotide binding]; other site 420246000184 CTC domain interface [polypeptide binding]; other site 420246000185 L16 interface [polypeptide binding]; other site 420246000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 420246000187 putative active site [active] 420246000188 catalytic residue [active] 420246000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 420246000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 420246000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 420246000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246000193 ATP binding site [chemical binding]; other site 420246000194 putative Mg++ binding site [ion binding]; other site 420246000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246000196 nucleotide binding region [chemical binding]; other site 420246000197 ATP-binding site [chemical binding]; other site 420246000198 TRCF domain; Region: TRCF; pfam03461 420246000199 stage V sporulation protein T; Region: spore_V_T; TIGR02851 420246000200 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 420246000201 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 420246000202 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 420246000203 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 420246000204 putative SAM binding site [chemical binding]; other site 420246000205 putative homodimer interface [polypeptide binding]; other site 420246000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 420246000207 homodimer interface [polypeptide binding]; other site 420246000208 metal binding site [ion binding]; metal-binding site 420246000209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 420246000210 homodimer interface [polypeptide binding]; other site 420246000211 active site 420246000212 putative chemical substrate binding site [chemical binding]; other site 420246000213 metal binding site [ion binding]; metal-binding site 420246000214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246000215 RNA binding surface [nucleotide binding]; other site 420246000216 sporulation protein YabP; Region: spore_yabP; TIGR02892 420246000217 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 420246000218 Septum formation initiator; Region: DivIC; pfam04977 420246000219 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 420246000220 hypothetical protein; Provisional; Region: PRK08582 420246000221 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 420246000222 RNA binding site [nucleotide binding]; other site 420246000223 stage II sporulation protein E; Region: spore_II_E; TIGR02865 420246000224 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 420246000225 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 420246000226 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 420246000227 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 420246000228 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 420246000229 metal ion-dependent adhesion site (MIDAS); other site 420246000230 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 420246000231 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 420246000232 active site 420246000233 substrate binding site [chemical binding]; other site 420246000234 ATP binding site [chemical binding]; other site 420246000235 activation loop (A-loop); other site 420246000236 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 420246000237 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 420246000238 Ligand Binding Site [chemical binding]; other site 420246000239 TilS substrate C-terminal domain; Region: TilS_C; smart00977 420246000240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246000241 active site 420246000242 FtsH Extracellular; Region: FtsH_ext; pfam06480 420246000243 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 420246000244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000245 Walker A motif; other site 420246000246 ATP binding site [chemical binding]; other site 420246000247 Walker B motif; other site 420246000248 arginine finger; other site 420246000249 Peptidase family M41; Region: Peptidase_M41; pfam01434 420246000250 pantothenate kinase; Reviewed; Region: PRK13318 420246000251 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 420246000252 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 420246000253 dimerization interface [polypeptide binding]; other site 420246000254 domain crossover interface; other site 420246000255 redox-dependent activation switch; other site 420246000256 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 420246000257 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 420246000258 dimer interface [polypeptide binding]; other site 420246000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246000260 catalytic residue [active] 420246000261 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 420246000262 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 420246000263 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 420246000264 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 420246000265 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 420246000266 glutamine binding [chemical binding]; other site 420246000267 catalytic triad [active] 420246000268 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 420246000269 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 420246000270 homodimer interface [polypeptide binding]; other site 420246000271 substrate-cofactor binding pocket; other site 420246000272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246000273 catalytic residue [active] 420246000274 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 420246000275 dihydropteroate synthase; Region: DHPS; TIGR01496 420246000276 substrate binding pocket [chemical binding]; other site 420246000277 dimer interface [polypeptide binding]; other site 420246000278 inhibitor binding site; inhibition site 420246000279 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 420246000280 homooctamer interface [polypeptide binding]; other site 420246000281 active site 420246000282 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 420246000283 catalytic center binding site [active] 420246000284 ATP binding site [chemical binding]; other site 420246000285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246000286 non-specific DNA binding site [nucleotide binding]; other site 420246000287 salt bridge; other site 420246000288 sequence-specific DNA binding site [nucleotide binding]; other site 420246000289 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 420246000290 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 420246000291 FMN binding site [chemical binding]; other site 420246000292 active site 420246000293 catalytic residues [active] 420246000294 substrate binding site [chemical binding]; other site 420246000295 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 420246000296 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 420246000297 dimer interface [polypeptide binding]; other site 420246000298 putative anticodon binding site; other site 420246000299 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 420246000300 motif 1; other site 420246000301 active site 420246000302 motif 2; other site 420246000303 motif 3; other site 420246000304 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 420246000305 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 420246000306 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 420246000307 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 420246000308 ADP binding site [chemical binding]; other site 420246000309 phosphagen binding site; other site 420246000310 substrate specificity loop; other site 420246000311 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 420246000312 Clp amino terminal domain; Region: Clp_N; pfam02861 420246000313 Clp amino terminal domain; Region: Clp_N; pfam02861 420246000314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000315 Walker A motif; other site 420246000316 ATP binding site [chemical binding]; other site 420246000317 Walker B motif; other site 420246000318 arginine finger; other site 420246000319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000320 Walker A motif; other site 420246000321 ATP binding site [chemical binding]; other site 420246000322 Walker B motif; other site 420246000323 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 420246000324 DNA repair protein RadA; Provisional; Region: PRK11823 420246000325 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 420246000326 Walker A motif/ATP binding site; other site 420246000327 ATP binding site [chemical binding]; other site 420246000328 Walker B motif; other site 420246000329 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 420246000330 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 420246000331 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 420246000332 putative active site [active] 420246000333 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 420246000334 substrate binding site; other site 420246000335 dimer interface; other site 420246000336 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 420246000337 homotrimer interaction site [polypeptide binding]; other site 420246000338 zinc binding site [ion binding]; other site 420246000339 CDP-binding sites; other site 420246000340 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 420246000341 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 420246000342 HIGH motif; other site 420246000343 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 420246000344 active site 420246000345 KMSKS motif; other site 420246000346 serine O-acetyltransferase; Region: cysE; TIGR01172 420246000347 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 420246000348 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 420246000349 trimer interface [polypeptide binding]; other site 420246000350 active site 420246000351 substrate binding site [chemical binding]; other site 420246000352 CoA binding site [chemical binding]; other site 420246000353 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 420246000354 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 420246000355 active site 420246000356 HIGH motif; other site 420246000357 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 420246000358 KMSKS motif; other site 420246000359 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 420246000360 tRNA binding surface [nucleotide binding]; other site 420246000361 anticodon binding site; other site 420246000362 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 420246000363 active site 420246000364 metal binding site [ion binding]; metal-binding site 420246000365 dimerization interface [polypeptide binding]; other site 420246000366 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 420246000367 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 420246000368 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 420246000369 YacP-like NYN domain; Region: NYN_YacP; cl01491 420246000370 RNA polymerase factor sigma-70; Validated; Region: PRK08295 420246000371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246000372 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 420246000373 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 420246000374 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 420246000375 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 420246000376 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 420246000377 putative homodimer interface [polypeptide binding]; other site 420246000378 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 420246000379 heterodimer interface [polypeptide binding]; other site 420246000380 homodimer interface [polypeptide binding]; other site 420246000381 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 420246000382 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 420246000383 23S rRNA interface [nucleotide binding]; other site 420246000384 L7/L12 interface [polypeptide binding]; other site 420246000385 putative thiostrepton binding site; other site 420246000386 L25 interface [polypeptide binding]; other site 420246000387 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 420246000388 mRNA/rRNA interface [nucleotide binding]; other site 420246000389 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 420246000390 23S rRNA interface [nucleotide binding]; other site 420246000391 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 420246000392 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 420246000393 core dimer interface [polypeptide binding]; other site 420246000394 peripheral dimer interface [polypeptide binding]; other site 420246000395 L10 interface [polypeptide binding]; other site 420246000396 L11 interface [polypeptide binding]; other site 420246000397 putative EF-Tu interaction site [polypeptide binding]; other site 420246000398 putative EF-G interaction site [polypeptide binding]; other site 420246000399 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 420246000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246000401 S-adenosylmethionine binding site [chemical binding]; other site 420246000402 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 420246000403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 420246000404 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 420246000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 420246000406 RPB1 interaction site [polypeptide binding]; other site 420246000407 RPB10 interaction site [polypeptide binding]; other site 420246000408 RPB11 interaction site [polypeptide binding]; other site 420246000409 RPB3 interaction site [polypeptide binding]; other site 420246000410 RPB12 interaction site [polypeptide binding]; other site 420246000411 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 420246000412 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 420246000413 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 420246000414 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 420246000415 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 420246000416 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 420246000417 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 420246000418 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 420246000419 G-loop; other site 420246000420 DNA binding site [nucleotide binding] 420246000421 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 420246000422 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 420246000423 S17 interaction site [polypeptide binding]; other site 420246000424 S8 interaction site; other site 420246000425 16S rRNA interaction site [nucleotide binding]; other site 420246000426 streptomycin interaction site [chemical binding]; other site 420246000427 23S rRNA interaction site [nucleotide binding]; other site 420246000428 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 420246000429 30S ribosomal protein S7; Validated; Region: PRK05302 420246000430 elongation factor G; Reviewed; Region: PRK00007 420246000431 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 420246000432 G1 box; other site 420246000433 putative GEF interaction site [polypeptide binding]; other site 420246000434 GTP/Mg2+ binding site [chemical binding]; other site 420246000435 Switch I region; other site 420246000436 G2 box; other site 420246000437 G3 box; other site 420246000438 Switch II region; other site 420246000439 G4 box; other site 420246000440 G5 box; other site 420246000441 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 420246000442 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 420246000443 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 420246000444 elongation factor Tu; Reviewed; Region: PRK00049 420246000445 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 420246000446 G1 box; other site 420246000447 GEF interaction site [polypeptide binding]; other site 420246000448 GTP/Mg2+ binding site [chemical binding]; other site 420246000449 Switch I region; other site 420246000450 G2 box; other site 420246000451 G3 box; other site 420246000452 Switch II region; other site 420246000453 G4 box; other site 420246000454 G5 box; other site 420246000455 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 420246000456 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 420246000457 Antibiotic Binding Site [chemical binding]; other site 420246000458 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 420246000459 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 420246000460 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 420246000461 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 420246000462 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 420246000463 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 420246000464 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 420246000465 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 420246000466 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 420246000467 putative translocon binding site; other site 420246000468 protein-rRNA interface [nucleotide binding]; other site 420246000469 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 420246000470 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 420246000471 G-X-X-G motif; other site 420246000472 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 420246000473 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 420246000474 23S rRNA interface [nucleotide binding]; other site 420246000475 5S rRNA interface [nucleotide binding]; other site 420246000476 putative antibiotic binding site [chemical binding]; other site 420246000477 L25 interface [polypeptide binding]; other site 420246000478 L27 interface [polypeptide binding]; other site 420246000479 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 420246000480 23S rRNA interface [nucleotide binding]; other site 420246000481 putative translocon interaction site; other site 420246000482 signal recognition particle (SRP54) interaction site; other site 420246000483 L23 interface [polypeptide binding]; other site 420246000484 trigger factor interaction site; other site 420246000485 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 420246000486 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 420246000487 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 420246000488 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 420246000489 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 420246000490 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 420246000491 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 420246000492 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 420246000493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 420246000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 420246000495 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 420246000496 5S rRNA interface [nucleotide binding]; other site 420246000497 L27 interface [polypeptide binding]; other site 420246000498 23S rRNA interface [nucleotide binding]; other site 420246000499 L5 interface [polypeptide binding]; other site 420246000500 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 420246000501 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 420246000502 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 420246000503 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 420246000504 23S rRNA binding site [nucleotide binding]; other site 420246000505 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 420246000506 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 420246000507 SecY translocase; Region: SecY; pfam00344 420246000508 adenylate kinase; Reviewed; Region: adk; PRK00279 420246000509 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 420246000510 AMP-binding site [chemical binding]; other site 420246000511 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 420246000512 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 420246000513 active site 420246000514 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 420246000515 rRNA binding site [nucleotide binding]; other site 420246000516 predicted 30S ribosome binding site; other site 420246000517 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 420246000518 30S ribosomal protein S13; Region: bact_S13; TIGR03631 420246000519 30S ribosomal protein S11; Validated; Region: PRK05309 420246000520 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 420246000521 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 420246000522 alphaNTD - beta interaction site [polypeptide binding]; other site 420246000523 alphaNTD homodimer interface [polypeptide binding]; other site 420246000524 alphaNTD - beta' interaction site [polypeptide binding]; other site 420246000525 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 420246000526 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 420246000527 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 420246000528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 420246000529 Walker A/P-loop; other site 420246000530 ATP binding site [chemical binding]; other site 420246000531 Q-loop/lid; other site 420246000532 ABC transporter signature motif; other site 420246000533 Walker B; other site 420246000534 D-loop; other site 420246000535 H-loop/switch region; other site 420246000536 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 420246000537 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 420246000538 Walker A/P-loop; other site 420246000539 ATP binding site [chemical binding]; other site 420246000540 Q-loop/lid; other site 420246000541 ABC transporter signature motif; other site 420246000542 Walker B; other site 420246000543 D-loop; other site 420246000544 H-loop/switch region; other site 420246000545 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 420246000546 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 420246000547 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 420246000548 dimerization interface 3.5A [polypeptide binding]; other site 420246000549 active site 420246000550 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 420246000551 23S rRNA interface [nucleotide binding]; other site 420246000552 L3 interface [polypeptide binding]; other site 420246000553 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 420246000554 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 420246000555 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 420246000556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 420246000557 active site 420246000558 metal binding site [ion binding]; metal-binding site 420246000559 Domain of unknown function DUF59; Region: DUF59; cl00941 420246000560 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 420246000561 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 420246000562 Walker A motif; other site 420246000563 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 420246000564 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 420246000565 Arginase family; Region: Arginase; cd09989 420246000566 agmatinase; Region: agmatinase; TIGR01230 420246000567 active site 420246000568 Mn binding site [ion binding]; other site 420246000569 oligomer interface [polypeptide binding]; other site 420246000570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246000571 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246000572 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 420246000573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246000574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246000575 DNA binding residues [nucleotide binding] 420246000576 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 420246000577 Putative zinc-finger; Region: zf-HC2; pfam13490 420246000578 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 420246000579 Uncharacterized conserved protein [Function unknown]; Region: COG1624 420246000580 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 420246000581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 420246000582 YbbR-like protein; Region: YbbR; pfam07949 420246000583 YbbR-like protein; Region: YbbR; pfam07949 420246000584 YbbR-like protein; Region: YbbR; pfam07949 420246000585 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 420246000586 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 420246000587 active site 420246000588 substrate binding site [chemical binding]; other site 420246000589 metal binding site [ion binding]; metal-binding site 420246000590 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 420246000591 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 420246000592 glutaminase active site [active] 420246000593 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 420246000594 dimer interface [polypeptide binding]; other site 420246000595 active site 420246000596 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 420246000597 dimer interface [polypeptide binding]; other site 420246000598 active site 420246000599 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 420246000600 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246000601 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246000602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246000603 dimer interface [polypeptide binding]; other site 420246000604 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 420246000605 conserved gate region; other site 420246000606 putative PBP binding loops; other site 420246000607 ABC-ATPase subunit interface; other site 420246000608 Uncharacterized conserved protein [Function unknown]; Region: COG1479 420246000609 Protein of unknown function DUF262; Region: DUF262; pfam03235 420246000610 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 420246000611 Uncharacterized conserved protein [Function unknown]; Region: COG3586 420246000612 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 420246000613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246000614 salt bridge; other site 420246000615 non-specific DNA binding site [nucleotide binding]; other site 420246000616 sequence-specific DNA binding site [nucleotide binding]; other site 420246000617 Protein of unknown function (DUF817); Region: DUF817; pfam05675 420246000618 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 420246000619 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 420246000620 Predicted membrane protein [Function unknown]; Region: COG2259 420246000621 PAS fold; Region: PAS; pfam00989 420246000622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246000623 putative active site [active] 420246000624 heme pocket [chemical binding]; other site 420246000625 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 420246000626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000627 Walker A motif; other site 420246000628 ATP binding site [chemical binding]; other site 420246000629 Walker B motif; other site 420246000630 arginine finger; other site 420246000631 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 420246000632 S-methylmethionine transporter; Provisional; Region: PRK11387 420246000633 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 420246000634 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 420246000635 Glutamate binding site [chemical binding]; other site 420246000636 homodimer interface [polypeptide binding]; other site 420246000637 NAD binding site [chemical binding]; other site 420246000638 catalytic residues [active] 420246000639 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 420246000640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 420246000641 inhibitor-cofactor binding pocket; inhibition site 420246000642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246000643 catalytic residue [active] 420246000644 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 420246000645 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 420246000646 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 420246000647 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246000648 dimer interface [polypeptide binding]; other site 420246000649 putative PBP binding regions; other site 420246000650 ABC-ATPase subunit interface; other site 420246000651 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 420246000652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246000653 ABC-ATPase subunit interface; other site 420246000654 dimer interface [polypeptide binding]; other site 420246000655 putative PBP binding regions; other site 420246000656 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 420246000657 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 420246000658 putative ligand binding residues [chemical binding]; other site 420246000659 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 420246000660 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 420246000661 Walker A/P-loop; other site 420246000662 ATP binding site [chemical binding]; other site 420246000663 Q-loop/lid; other site 420246000664 ABC transporter signature motif; other site 420246000665 Walker B; other site 420246000666 D-loop; other site 420246000667 H-loop/switch region; other site 420246000668 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 420246000669 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 420246000670 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 420246000671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246000672 putative active site [active] 420246000673 heme pocket [chemical binding]; other site 420246000674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000675 Walker A motif; other site 420246000676 ATP binding site [chemical binding]; other site 420246000677 Walker B motif; other site 420246000678 arginine finger; other site 420246000679 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 420246000680 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246000681 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 420246000682 active site 420246000683 Predicted membrane protein [Function unknown]; Region: COG2259 420246000684 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 420246000685 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 420246000686 catalytic residues [active] 420246000687 DinB family; Region: DinB; cl17821 420246000688 DinB superfamily; Region: DinB_2; pfam12867 420246000689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246000690 dimerization interface [polypeptide binding]; other site 420246000691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246000692 dimer interface [polypeptide binding]; other site 420246000693 phosphorylation site [posttranslational modification] 420246000694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246000695 ATP binding site [chemical binding]; other site 420246000696 Mg2+ binding site [ion binding]; other site 420246000697 G-X-G motif; other site 420246000698 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246000699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246000700 active site 420246000701 phosphorylation site [posttranslational modification] 420246000702 intermolecular recognition site; other site 420246000703 dimerization interface [polypeptide binding]; other site 420246000704 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246000705 DNA binding site [nucleotide binding] 420246000706 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 420246000707 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 420246000708 active site 420246000709 metal binding site [ion binding]; metal-binding site 420246000710 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 420246000711 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 420246000712 active site 420246000713 catalytic triad [active] 420246000714 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 420246000715 Sulfatase; Region: Sulfatase; pfam00884 420246000716 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 420246000717 Domain of unknown function DUF; Region: DUF204; pfam02659 420246000718 Domain of unknown function DUF; Region: DUF204; pfam02659 420246000719 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 420246000720 SpoOM protein; Region: Spo0M; pfam07070 420246000721 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 420246000722 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 420246000723 nucleotide binding site [chemical binding]; other site 420246000724 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 420246000725 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 420246000726 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 420246000727 active site 420246000728 homodimer interface [polypeptide binding]; other site 420246000729 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 420246000730 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 420246000731 NodB motif; other site 420246000732 putative active site [active] 420246000733 putative catalytic site [active] 420246000734 putative Zn binding site [ion binding]; other site 420246000735 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 420246000736 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 420246000737 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 420246000738 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 420246000739 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 420246000740 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 420246000741 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 420246000742 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 420246000743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 420246000744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 420246000745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 420246000746 Esterase/lipase [General function prediction only]; Region: COG1647 420246000747 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 420246000748 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 420246000749 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 420246000750 ATP binding site [chemical binding]; other site 420246000751 Mg++ binding site [ion binding]; other site 420246000752 motif III; other site 420246000753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246000754 nucleotide binding region [chemical binding]; other site 420246000755 ATP-binding site [chemical binding]; other site 420246000756 Rhomboid family; Region: Rhomboid; pfam01694 420246000757 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 420246000758 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 420246000759 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 420246000760 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 420246000761 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 420246000762 active site 420246000763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 420246000764 dimer interface [polypeptide binding]; other site 420246000765 substrate binding site [chemical binding]; other site 420246000766 catalytic residues [active] 420246000767 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 420246000768 PemK-like protein; Region: PemK; pfam02452 420246000769 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 420246000770 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 420246000771 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 420246000772 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 420246000773 RNA binding site [nucleotide binding]; other site 420246000774 hypothetical protein; Provisional; Region: PRK04351 420246000775 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 420246000776 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 420246000777 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 420246000778 Glycoprotease family; Region: Peptidase_M22; pfam00814 420246000779 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 420246000780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246000781 Coenzyme A binding pocket [chemical binding]; other site 420246000782 UGMP family protein; Validated; Region: PRK09604 420246000783 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 420246000784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 420246000785 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 420246000786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 420246000787 ABC transporter; Region: ABC_tran_2; pfam12848 420246000788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 420246000789 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 420246000790 trimer interface [polypeptide binding]; other site 420246000791 dimer interface [polypeptide binding]; other site 420246000792 putative active site [active] 420246000793 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 420246000794 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 420246000795 CoA binding domain; Region: CoA_binding; pfam02629 420246000796 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 420246000797 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 420246000798 CAAX protease self-immunity; Region: Abi; pfam02517 420246000799 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 420246000800 oligomerisation interface [polypeptide binding]; other site 420246000801 mobile loop; other site 420246000802 roof hairpin; other site 420246000803 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 420246000804 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 420246000805 ring oligomerisation interface [polypeptide binding]; other site 420246000806 ATP/Mg binding site [chemical binding]; other site 420246000807 stacking interactions; other site 420246000808 hinge regions; other site 420246000809 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 420246000810 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 420246000811 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 420246000812 TrkA-C domain; Region: TrkA_C; pfam02080 420246000813 fumarate hydratase; Reviewed; Region: fumC; PRK00485 420246000814 Class II fumarases; Region: Fumarase_classII; cd01362 420246000815 active site 420246000816 tetramer interface [polypeptide binding]; other site 420246000817 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 420246000818 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 420246000819 MoxR-like ATPases [General function prediction only]; Region: COG0714 420246000820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246000821 Walker A motif; other site 420246000822 ATP binding site [chemical binding]; other site 420246000823 Walker B motif; other site 420246000824 arginine finger; other site 420246000825 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 420246000826 Protein of unknown function DUF58; Region: DUF58; pfam01882 420246000827 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 420246000828 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 420246000829 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 420246000830 GMP synthase; Reviewed; Region: guaA; PRK00074 420246000831 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 420246000832 AMP/PPi binding site [chemical binding]; other site 420246000833 candidate oxyanion hole; other site 420246000834 catalytic triad [active] 420246000835 potential glutamine specificity residues [chemical binding]; other site 420246000836 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 420246000837 ATP Binding subdomain [chemical binding]; other site 420246000838 Ligand Binding sites [chemical binding]; other site 420246000839 Dimerization subdomain; other site 420246000840 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246000841 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246000842 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 420246000843 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 420246000844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246000845 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 420246000846 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 420246000847 putative dimer interface [polypeptide binding]; other site 420246000848 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 420246000849 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 420246000850 ATP-grasp domain; Region: ATP-grasp; pfam02222 420246000851 adenylosuccinate lyase; Provisional; Region: PRK07492 420246000852 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 420246000853 tetramer interface [polypeptide binding]; other site 420246000854 active site 420246000855 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 420246000856 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 420246000857 ATP binding site [chemical binding]; other site 420246000858 active site 420246000859 substrate binding site [chemical binding]; other site 420246000860 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 420246000861 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 420246000862 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 420246000863 putative active site [active] 420246000864 catalytic triad [active] 420246000865 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 420246000866 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 420246000867 dimerization interface [polypeptide binding]; other site 420246000868 ATP binding site [chemical binding]; other site 420246000869 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 420246000870 dimerization interface [polypeptide binding]; other site 420246000871 ATP binding site [chemical binding]; other site 420246000872 amidophosphoribosyltransferase; Provisional; Region: PRK07631 420246000873 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 420246000874 active site 420246000875 tetramer interface [polypeptide binding]; other site 420246000876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246000877 active site 420246000878 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 420246000879 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 420246000880 dimerization interface [polypeptide binding]; other site 420246000881 putative ATP binding site [chemical binding]; other site 420246000882 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 420246000883 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 420246000884 active site 420246000885 substrate binding site [chemical binding]; other site 420246000886 cosubstrate binding site; other site 420246000887 catalytic site [active] 420246000888 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 420246000889 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 420246000890 purine monophosphate binding site [chemical binding]; other site 420246000891 dimer interface [polypeptide binding]; other site 420246000892 putative catalytic residues [active] 420246000893 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 420246000894 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 420246000895 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 420246000896 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 420246000897 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 420246000898 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 420246000899 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 420246000900 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 420246000901 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 420246000902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 420246000903 active site 420246000904 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 420246000905 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 420246000906 Probable transposase; Region: OrfB_IS605; pfam01385 420246000907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 420246000908 PcrB family; Region: PcrB; pfam01884 420246000909 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 420246000910 substrate binding site [chemical binding]; other site 420246000911 putative active site [active] 420246000912 dimer interface [polypeptide binding]; other site 420246000913 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 420246000914 Part of AAA domain; Region: AAA_19; pfam13245 420246000915 AAA domain; Region: AAA_12; pfam13087 420246000916 Family description; Region: UvrD_C_2; pfam13538 420246000917 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 420246000918 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 420246000919 nucleotide binding pocket [chemical binding]; other site 420246000920 K-X-D-G motif; other site 420246000921 catalytic site [active] 420246000922 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 420246000923 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 420246000924 Helix-hairpin-helix motif; Region: HHH; pfam00633 420246000925 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 420246000926 Dimer interface [polypeptide binding]; other site 420246000927 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 420246000928 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 420246000929 putative dimer interface [polypeptide binding]; other site 420246000930 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 420246000931 putative dimer interface [polypeptide binding]; other site 420246000932 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 420246000933 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 420246000934 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 420246000935 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 420246000936 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 420246000937 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 420246000938 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 420246000939 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 420246000940 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 420246000941 GatB domain; Region: GatB_Yqey; pfam02637 420246000942 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 420246000943 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 420246000944 homodimer interface [polypeptide binding]; other site 420246000945 substrate-cofactor binding pocket; other site 420246000946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246000947 catalytic residue [active] 420246000948 lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731 420246000949 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 420246000950 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 420246000951 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 420246000952 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 420246000953 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 420246000954 Walker A/P-loop; other site 420246000955 ATP binding site [chemical binding]; other site 420246000956 Q-loop/lid; other site 420246000957 ABC transporter signature motif; other site 420246000958 Walker B; other site 420246000959 D-loop; other site 420246000960 H-loop/switch region; other site 420246000961 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 420246000962 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 420246000963 active site 420246000964 zinc binding site [ion binding]; other site 420246000965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246000966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246000967 active site 420246000968 phosphorylation site [posttranslational modification] 420246000969 intermolecular recognition site; other site 420246000970 dimerization interface [polypeptide binding]; other site 420246000971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246000972 DNA binding site [nucleotide binding] 420246000973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246000974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 420246000975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246000976 dimer interface [polypeptide binding]; other site 420246000977 phosphorylation site [posttranslational modification] 420246000978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246000979 ATP binding site [chemical binding]; other site 420246000980 Mg2+ binding site [ion binding]; other site 420246000981 G-X-G motif; other site 420246000982 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 420246000983 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 420246000984 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 420246000985 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 420246000986 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 420246000987 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 420246000988 Walker A/P-loop; other site 420246000989 ATP binding site [chemical binding]; other site 420246000990 Q-loop/lid; other site 420246000991 ABC transporter signature motif; other site 420246000992 Walker B; other site 420246000993 D-loop; other site 420246000994 H-loop/switch region; other site 420246000995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246000996 ABC-ATPase subunit interface; other site 420246000997 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 420246000998 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 420246000999 Walker A/P-loop; other site 420246001000 ATP binding site [chemical binding]; other site 420246001001 Q-loop/lid; other site 420246001002 ABC transporter signature motif; other site 420246001003 Walker B; other site 420246001004 D-loop; other site 420246001005 H-loop/switch region; other site 420246001006 FOG: CBS domain [General function prediction only]; Region: COG0517 420246001007 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 420246001008 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 420246001009 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 420246001010 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 420246001011 drug efflux system protein MdtG; Provisional; Region: PRK09874 420246001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001013 putative substrate translocation pore; other site 420246001014 phage shock protein A; Region: phageshock_pspA; TIGR02977 420246001015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246001016 dimer interface [polypeptide binding]; other site 420246001017 phosphorylation site [posttranslational modification] 420246001018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246001019 ATP binding site [chemical binding]; other site 420246001020 Mg2+ binding site [ion binding]; other site 420246001021 G-X-G motif; other site 420246001022 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246001023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246001024 active site 420246001025 phosphorylation site [posttranslational modification] 420246001026 intermolecular recognition site; other site 420246001027 dimerization interface [polypeptide binding]; other site 420246001028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246001029 DNA binding site [nucleotide binding] 420246001030 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 420246001031 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 420246001032 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 420246001033 protein binding site [polypeptide binding]; other site 420246001034 Protein of unknown function (DUF997); Region: DUF997; pfam06196 420246001035 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 420246001036 Na binding site [ion binding]; other site 420246001037 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 420246001038 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 420246001039 metal binding site [ion binding]; metal-binding site 420246001040 dimer interface [polypeptide binding]; other site 420246001041 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 420246001042 tartrate dehydrogenase; Region: TTC; TIGR02089 420246001043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 420246001044 classical (c) SDRs; Region: SDR_c; cd05233 420246001045 NAD(P) binding site [chemical binding]; other site 420246001046 active site 420246001047 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246001048 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 420246001049 NAD(P) binding site [chemical binding]; other site 420246001050 catalytic residues [active] 420246001051 catalytic residues [active] 420246001052 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 420246001053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 420246001054 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 420246001055 putative lipid kinase; Reviewed; Region: PRK13337 420246001056 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 420246001057 TRAM domain; Region: TRAM; cl01282 420246001058 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 420246001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246001060 S-adenosylmethionine binding site [chemical binding]; other site 420246001061 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 420246001062 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 420246001063 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 420246001064 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 420246001065 Walker A/P-loop; other site 420246001066 ATP binding site [chemical binding]; other site 420246001067 Q-loop/lid; other site 420246001068 ABC transporter signature motif; other site 420246001069 Walker B; other site 420246001070 D-loop; other site 420246001071 H-loop/switch region; other site 420246001072 FtsX-like permease family; Region: FtsX; pfam02687 420246001073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 420246001074 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 420246001075 Predicted transcriptional regulators [Transcription]; Region: COG1695 420246001076 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 420246001077 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 420246001078 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 420246001079 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 420246001080 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 420246001081 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 420246001082 active site 420246001083 NTP binding site [chemical binding]; other site 420246001084 metal binding triad [ion binding]; metal-binding site 420246001085 antibiotic binding site [chemical binding]; other site 420246001086 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 420246001087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246001088 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246001089 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 420246001090 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 420246001091 serine/threonine transporter SstT; Provisional; Region: PRK13628 420246001092 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 420246001093 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 420246001094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246001095 S-adenosylmethionine binding site [chemical binding]; other site 420246001096 Holin family; Region: Phage_holin_4; pfam05105 420246001097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 420246001098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246001099 non-specific DNA binding site [nucleotide binding]; other site 420246001100 salt bridge; other site 420246001101 sequence-specific DNA binding site [nucleotide binding]; other site 420246001102 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246001103 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246001104 Transposase, Mutator family; Region: Transposase_mut; pfam00872 420246001105 MULE transposase domain; Region: MULE; pfam10551 420246001106 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 420246001107 Carbon starvation protein CstA; Region: CstA; pfam02554 420246001108 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 420246001109 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 420246001110 Zeta toxin; Region: Zeta_toxin; pfam06414 420246001111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 420246001112 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 420246001113 SpoOM protein; Region: Spo0M; pfam07070 420246001114 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 420246001115 active site 420246001116 8-oxo-dGMP binding site [chemical binding]; other site 420246001117 nudix motif; other site 420246001118 metal binding site [ion binding]; metal-binding site 420246001119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246001120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246001121 dimerization interface [polypeptide binding]; other site 420246001122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246001123 dimer interface [polypeptide binding]; other site 420246001124 phosphorylation site [posttranslational modification] 420246001125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246001126 ATP binding site [chemical binding]; other site 420246001127 Mg2+ binding site [ion binding]; other site 420246001128 G-X-G motif; other site 420246001129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246001130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246001131 active site 420246001132 phosphorylation site [posttranslational modification] 420246001133 intermolecular recognition site; other site 420246001134 dimerization interface [polypeptide binding]; other site 420246001135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246001136 DNA binding site [nucleotide binding] 420246001137 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 420246001138 FtsX-like permease family; Region: FtsX; pfam02687 420246001139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 420246001140 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 420246001141 FtsX-like permease family; Region: FtsX; pfam02687 420246001142 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 420246001143 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 420246001144 Walker A/P-loop; other site 420246001145 ATP binding site [chemical binding]; other site 420246001146 Q-loop/lid; other site 420246001147 ABC transporter signature motif; other site 420246001148 Walker B; other site 420246001149 D-loop; other site 420246001150 H-loop/switch region; other site 420246001151 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246001152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246001153 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 420246001154 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 420246001155 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 420246001156 active site 420246001157 Substrate binding site; other site 420246001158 Mg++ binding site; other site 420246001159 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 420246001160 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 420246001161 putative trimer interface [polypeptide binding]; other site 420246001162 putative CoA binding site [chemical binding]; other site 420246001163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246001164 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 420246001165 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 420246001166 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 420246001167 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 420246001168 active site 420246001169 substrate binding site [chemical binding]; other site 420246001170 metal binding site [ion binding]; metal-binding site 420246001171 Sensory domain found in PocR; Region: PocR; pfam10114 420246001172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 420246001173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 420246001174 DNA binding residues [nucleotide binding] 420246001175 dimerization interface [polypeptide binding]; other site 420246001176 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 420246001177 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 420246001178 anti sigma factor interaction site; other site 420246001179 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 420246001180 regulatory phosphorylation site [posttranslational modification]; other site 420246001181 PAS domain; Region: PAS_9; pfam13426 420246001182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246001183 putative active site [active] 420246001184 heme pocket [chemical binding]; other site 420246001185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246001186 PAS domain; Region: PAS_9; pfam13426 420246001187 putative active site [active] 420246001188 heme pocket [chemical binding]; other site 420246001189 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 420246001190 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 420246001191 RDD family; Region: RDD; pfam06271 420246001192 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 420246001193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246001194 dimerization interface [polypeptide binding]; other site 420246001195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 420246001196 dimer interface [polypeptide binding]; other site 420246001197 putative CheW interface [polypeptide binding]; other site 420246001198 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 420246001199 ThiC-associated domain; Region: ThiC-associated; pfam13667 420246001200 ThiC family; Region: ThiC; pfam01964 420246001201 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 420246001202 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246001203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246001204 homodimer interface [polypeptide binding]; other site 420246001205 catalytic residue [active] 420246001206 thiamine pyrophosphate protein; Validated; Region: PRK08199 420246001207 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 420246001208 PYR/PP interface [polypeptide binding]; other site 420246001209 dimer interface [polypeptide binding]; other site 420246001210 TPP binding site [chemical binding]; other site 420246001211 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 420246001212 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 420246001213 TPP-binding site [chemical binding]; other site 420246001214 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 420246001215 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246001216 NAD(P) binding site [chemical binding]; other site 420246001217 catalytic residues [active] 420246001218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246001219 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 420246001220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246001222 putative substrate translocation pore; other site 420246001223 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 420246001224 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 420246001225 DNA binding residues [nucleotide binding] 420246001226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 420246001227 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 420246001228 catalytic loop [active] 420246001229 iron binding site [ion binding]; other site 420246001230 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 420246001231 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 420246001232 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 420246001233 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 420246001234 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 420246001235 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 420246001236 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 420246001237 Ligand binding site; other site 420246001238 metal-binding site 420246001239 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 420246001240 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 420246001241 XdhC Rossmann domain; Region: XdhC_C; pfam13478 420246001242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 420246001243 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 420246001244 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 420246001245 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 420246001246 hexamer interface [polypeptide binding]; other site 420246001247 RNA binding site [nucleotide binding]; other site 420246001248 Histidine-zinc binding site [chemical binding]; other site 420246001249 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 420246001250 active sites [active] 420246001251 tetramer interface [polypeptide binding]; other site 420246001252 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 420246001253 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246001254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246001255 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 420246001256 active site 420246001257 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 420246001258 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 420246001259 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 420246001260 NAD binding site [chemical binding]; other site 420246001261 ligand binding site [chemical binding]; other site 420246001262 catalytic site [active] 420246001263 Uncharacterized conserved protein [Function unknown]; Region: COG1556 420246001264 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 420246001265 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 420246001266 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 420246001267 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 420246001268 Cysteine-rich domain; Region: CCG; pfam02754 420246001269 Cysteine-rich domain; Region: CCG; pfam02754 420246001270 Transcriptional regulators [Transcription]; Region: FadR; COG2186 420246001271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246001272 DNA-binding site [nucleotide binding]; DNA binding site 420246001273 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 420246001274 L-lactate permease; Region: Lactate_perm; cl00701 420246001275 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 420246001276 FAD binding domain; Region: FAD_binding_4; pfam01565 420246001277 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 420246001278 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 420246001279 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 420246001280 Cysteine-rich domain; Region: CCG; pfam02754 420246001281 Cysteine-rich domain; Region: CCG; pfam02754 420246001282 rod shape-determining protein MreB; Provisional; Region: PRK13930 420246001283 MreB and similar proteins; Region: MreB_like; cd10225 420246001284 nucleotide binding site [chemical binding]; other site 420246001285 Mg binding site [ion binding]; other site 420246001286 putative protofilament interaction site [polypeptide binding]; other site 420246001287 RodZ interaction site [polypeptide binding]; other site 420246001288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246001289 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246001290 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 420246001291 NlpC/P60 family; Region: NLPC_P60; pfam00877 420246001292 PAS domain; Region: PAS_9; pfam13426 420246001293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246001294 putative active site [active] 420246001295 heme pocket [chemical binding]; other site 420246001296 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246001297 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246001298 metal binding site [ion binding]; metal-binding site 420246001299 active site 420246001300 I-site; other site 420246001301 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 420246001302 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 420246001303 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 420246001304 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 420246001305 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 420246001306 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 420246001307 active site 420246001308 metal binding site [ion binding]; metal-binding site 420246001309 acylphosphatase; Provisional; Region: PRK14420 420246001310 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 420246001311 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 420246001312 putative active site [active] 420246001313 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 420246001314 putative active site [active] 420246001315 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 420246001316 active site 420246001317 SAM binding site [chemical binding]; other site 420246001318 homodimer interface [polypeptide binding]; other site 420246001319 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 420246001320 ligand-binding site [chemical binding]; other site 420246001321 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 420246001322 ATP-sulfurylase; Region: ATPS; cd00517 420246001323 active site 420246001324 HXXH motif; other site 420246001325 flexible loop; other site 420246001326 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 420246001327 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 420246001328 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 420246001329 Active Sites [active] 420246001330 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 420246001331 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 420246001332 Low molecular weight phosphatase family; Region: LMWPc; cd00115 420246001333 active site 420246001334 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 420246001335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246001336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001337 putative substrate translocation pore; other site 420246001338 calcium/proton exchanger (cax); Region: cax; TIGR00378 420246001339 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 420246001340 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 420246001341 YfkD-like protein; Region: YfkD; pfam14167 420246001342 Radical SAM superfamily; Region: Radical_SAM; pfam04055 420246001343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246001344 FeS/SAM binding site; other site 420246001345 YfkB-like domain; Region: YfkB; pfam08756 420246001346 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 420246001347 Fumarase C-terminus; Region: Fumerase_C; pfam05683 420246001348 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 420246001349 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 420246001350 NodB motif; other site 420246001351 active site 420246001352 catalytic site [active] 420246001353 Cd binding site [ion binding]; other site 420246001354 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 420246001355 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 420246001356 minor groove reading motif; other site 420246001357 helix-hairpin-helix signature motif; other site 420246001358 substrate binding pocket [chemical binding]; other site 420246001359 active site 420246001360 TRAM domain; Region: TRAM; pfam01938 420246001361 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 420246001362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246001363 S-adenosylmethionine binding site [chemical binding]; other site 420246001364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246001365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246001366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246001368 putative substrate translocation pore; other site 420246001369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246001371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246001372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 420246001373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246001374 putative PBP binding loops; other site 420246001375 dimer interface [polypeptide binding]; other site 420246001376 ABC-ATPase subunit interface; other site 420246001377 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246001378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246001379 dimer interface [polypeptide binding]; other site 420246001380 conserved gate region; other site 420246001381 putative PBP binding loops; other site 420246001382 ABC-ATPase subunit interface; other site 420246001383 beta-D-glucuronidase; Provisional; Region: PRK10150 420246001384 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 420246001385 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 420246001386 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 420246001387 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 420246001388 EamA-like transporter family; Region: EamA; pfam00892 420246001389 EamA-like transporter family; Region: EamA; pfam00892 420246001390 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 420246001391 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 420246001392 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 420246001393 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 420246001394 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 420246001395 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 420246001396 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 420246001397 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 420246001398 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 420246001399 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 420246001400 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 420246001401 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 420246001402 Protein of unknown function (DUF996); Region: DUF996; cl00970 420246001403 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 420246001404 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 420246001405 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 420246001406 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 420246001407 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 420246001408 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 420246001409 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 420246001410 catalytic residues [active] 420246001411 catalytic nucleophile [active] 420246001412 Recombinase; Region: Recombinase; pfam07508 420246001413 putative transposase OrfB; Reviewed; Region: PHA02517 420246001414 HTH-like domain; Region: HTH_21; pfam13276 420246001415 Integrase core domain; Region: rve; pfam00665 420246001416 Integrase core domain; Region: rve_3; pfam13683 420246001417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246001418 Transposase; Region: HTH_Tnp_1; pfam01527 420246001419 VanZ like family; Region: VanZ; pfam04892 420246001420 phage shock protein A; Region: phageshock_pspA; TIGR02977 420246001421 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 420246001422 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 420246001423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246001424 Histidine kinase; Region: HisKA_3; pfam07730 420246001425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246001426 ATP binding site [chemical binding]; other site 420246001427 Mg2+ binding site [ion binding]; other site 420246001428 G-X-G motif; other site 420246001429 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 420246001430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246001431 active site 420246001432 phosphorylation site [posttranslational modification] 420246001433 intermolecular recognition site; other site 420246001434 dimerization interface [polypeptide binding]; other site 420246001435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 420246001436 DNA binding residues [nucleotide binding] 420246001437 dimerization interface [polypeptide binding]; other site 420246001438 Uncharacterized conserved protein [Function unknown]; Region: COG0397 420246001439 hypothetical protein; Validated; Region: PRK00029 420246001440 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 420246001441 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 420246001442 DNA binding residues [nucleotide binding] 420246001443 dimer interface [polypeptide binding]; other site 420246001444 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 420246001445 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 420246001446 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 420246001447 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 420246001448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 420246001449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 420246001450 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 420246001451 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 420246001452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246001453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246001454 DNA binding residues [nucleotide binding] 420246001455 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 420246001456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246001457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 420246001458 active site 420246001459 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 420246001460 CoA-transferase family III; Region: CoA_transf_3; pfam02515 420246001461 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 420246001462 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 420246001463 Ligand binding site; other site 420246001464 metal-binding site 420246001465 YfhD-like protein; Region: YfhD; pfam14151 420246001466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 420246001467 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 420246001468 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 420246001469 putative NAD(P) binding site [chemical binding]; other site 420246001470 putative active site [active] 420246001471 recombination regulator RecX; Provisional; Region: recX; PRK14135 420246001472 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 420246001473 YpzG-like protein; Region: YpzG; pfam14139 420246001474 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 420246001475 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 420246001476 Uncharacterized conserved protein [Function unknown]; Region: COG2427 420246001477 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 420246001478 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 420246001479 catalytic loop [active] 420246001480 iron binding site [ion binding]; other site 420246001481 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 420246001482 4Fe-4S binding domain; Region: Fer4; pfam00037 420246001483 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 420246001484 [4Fe-4S] binding site [ion binding]; other site 420246001485 molybdopterin cofactor binding site; other site 420246001486 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 420246001487 molybdopterin cofactor binding site; other site 420246001488 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 420246001489 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 420246001490 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 420246001491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001492 putative substrate translocation pore; other site 420246001493 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 420246001494 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 420246001495 minor groove reading motif; other site 420246001496 helix-hairpin-helix signature motif; other site 420246001497 substrate binding pocket [chemical binding]; other site 420246001498 active site 420246001499 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 420246001500 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 420246001501 DNA binding and oxoG recognition site [nucleotide binding] 420246001502 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 420246001503 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 420246001504 putative NAD(P) binding site [chemical binding]; other site 420246001505 active site 420246001506 YgaB-like protein; Region: YgaB; pfam14182 420246001507 hypothetical protein; Provisional; Region: PRK13662 420246001508 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 420246001509 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 420246001510 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 420246001511 Walker A/P-loop; other site 420246001512 ATP binding site [chemical binding]; other site 420246001513 Q-loop/lid; other site 420246001514 ABC transporter signature motif; other site 420246001515 Walker B; other site 420246001516 D-loop; other site 420246001517 H-loop/switch region; other site 420246001518 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 420246001519 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246001520 Walker A/P-loop; other site 420246001521 ATP binding site [chemical binding]; other site 420246001522 Q-loop/lid; other site 420246001523 ABC transporter signature motif; other site 420246001524 Walker B; other site 420246001525 D-loop; other site 420246001526 H-loop/switch region; other site 420246001527 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246001528 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 420246001529 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246001530 Walker A/P-loop; other site 420246001531 ATP binding site [chemical binding]; other site 420246001532 Q-loop/lid; other site 420246001533 ABC transporter signature motif; other site 420246001534 Walker B; other site 420246001535 D-loop; other site 420246001536 H-loop/switch region; other site 420246001537 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246001538 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 420246001539 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 420246001540 peptide binding site [polypeptide binding]; other site 420246001541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 420246001542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246001543 dimer interface [polypeptide binding]; other site 420246001544 conserved gate region; other site 420246001545 putative PBP binding loops; other site 420246001546 ABC-ATPase subunit interface; other site 420246001547 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 420246001548 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 420246001549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246001550 dimer interface [polypeptide binding]; other site 420246001551 conserved gate region; other site 420246001552 ABC-ATPase subunit interface; other site 420246001553 Predicted membrane protein [Function unknown]; Region: COG4129 420246001554 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 420246001555 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 420246001556 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 420246001557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 420246001558 inhibitor-cofactor binding pocket; inhibition site 420246001559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246001560 catalytic residue [active] 420246001561 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 420246001562 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 420246001563 Walker A/P-loop; other site 420246001564 ATP binding site [chemical binding]; other site 420246001565 Q-loop/lid; other site 420246001566 ABC transporter signature motif; other site 420246001567 Walker B; other site 420246001568 D-loop; other site 420246001569 H-loop/switch region; other site 420246001570 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 420246001571 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 420246001572 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 420246001573 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 420246001574 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 420246001575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 420246001576 NAD binding site [chemical binding]; other site 420246001577 dimer interface [polypeptide binding]; other site 420246001578 substrate binding site [chemical binding]; other site 420246001579 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 420246001580 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 420246001581 catalytic triad [active] 420246001582 ferric uptake regulator; Provisional; Region: fur; PRK09462 420246001583 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 420246001584 metal binding site 2 [ion binding]; metal-binding site 420246001585 putative DNA binding helix; other site 420246001586 metal binding site 1 [ion binding]; metal-binding site 420246001587 dimer interface [polypeptide binding]; other site 420246001588 structural Zn2+ binding site [ion binding]; other site 420246001589 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 420246001590 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 420246001591 B3/4 domain; Region: B3_4; pfam03483 420246001592 epoxyqueuosine reductase; Region: TIGR00276 420246001593 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 420246001594 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 420246001595 protein binding surface [polypeptide binding]; other site 420246001596 Putative amidase domain; Region: Amidase_6; pfam12671 420246001597 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 420246001598 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 420246001599 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 420246001600 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 420246001601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246001602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246001603 DNA binding site [nucleotide binding] 420246001604 domain linker motif; other site 420246001605 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 420246001606 putative ligand binding site [chemical binding]; other site 420246001607 putative dimerization interface [polypeptide binding]; other site 420246001608 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 420246001609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246001610 active site 420246001611 phosphorylation site [posttranslational modification] 420246001612 intermolecular recognition site; other site 420246001613 dimerization interface [polypeptide binding]; other site 420246001614 FaeA-like protein; Region: FaeA; pfam04703 420246001615 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 420246001616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246001617 putative active site [active] 420246001618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246001619 ATP binding site [chemical binding]; other site 420246001620 Mg2+ binding site [ion binding]; other site 420246001621 G-X-G motif; other site 420246001622 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 420246001623 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 420246001624 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 420246001625 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 420246001626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 420246001627 active site 420246001628 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 420246001629 catalytic tetrad [active] 420246001630 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 420246001631 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 420246001632 Domain of unknown function DUF21; Region: DUF21; pfam01595 420246001633 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 420246001634 Transporter associated domain; Region: CorC_HlyC; smart01091 420246001635 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 420246001636 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 420246001637 active site 420246001638 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 420246001639 catalytic residues [active] 420246001640 putative disulfide oxidoreductase; Provisional; Region: PRK03113 420246001641 FOG: CBS domain [General function prediction only]; Region: COG0517 420246001642 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 420246001643 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 420246001644 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 420246001645 active site 420246001646 substrate binding site [chemical binding]; other site 420246001647 metal binding site [ion binding]; metal-binding site 420246001648 YhdB-like protein; Region: YhdB; pfam14148 420246001649 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 420246001650 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 420246001651 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 420246001652 SpoVR like protein; Region: SpoVR; pfam04293 420246001653 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 420246001654 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 420246001655 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 420246001656 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 420246001657 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 420246001658 carbon starvation protein A; Provisional; Region: PRK15015 420246001659 Carbon starvation protein CstA; Region: CstA; pfam02554 420246001660 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 420246001661 Protein of unknown function (DUF466); Region: DUF466; pfam04328 420246001662 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 420246001663 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 420246001664 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 420246001665 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 420246001666 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 420246001667 Ca binding site [ion binding]; other site 420246001668 active site 420246001669 catalytic site [active] 420246001670 metal-dependent hydrolase; Provisional; Region: PRK13291 420246001671 DinB superfamily; Region: DinB_2; pfam12867 420246001672 major facilitator superfamily transporter; Provisional; Region: PRK05122 420246001673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246001674 putative substrate translocation pore; other site 420246001675 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 420246001676 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 420246001677 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 420246001678 putative RNA binding site [nucleotide binding]; other site 420246001679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246001680 S-adenosylmethionine binding site [chemical binding]; other site 420246001681 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 420246001682 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 420246001683 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 420246001684 Walker A/P-loop; other site 420246001685 ATP binding site [chemical binding]; other site 420246001686 Q-loop/lid; other site 420246001687 ABC transporter signature motif; other site 420246001688 Walker B; other site 420246001689 D-loop; other site 420246001690 H-loop/switch region; other site 420246001691 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 420246001692 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 420246001693 Walker A/P-loop; other site 420246001694 ATP binding site [chemical binding]; other site 420246001695 Q-loop/lid; other site 420246001696 ABC transporter signature motif; other site 420246001697 Walker B; other site 420246001698 D-loop; other site 420246001699 H-loop/switch region; other site 420246001700 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 420246001701 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 420246001702 thiamine phosphate binding site [chemical binding]; other site 420246001703 active site 420246001704 pyrophosphate binding site [ion binding]; other site 420246001705 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 420246001706 hydroxyglutarate oxidase; Provisional; Region: PRK11728 420246001707 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 420246001708 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 420246001709 thiS-thiF/thiG interaction site; other site 420246001710 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 420246001711 ThiS interaction site; other site 420246001712 putative active site [active] 420246001713 tetramer interface [polypeptide binding]; other site 420246001714 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 420246001715 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 420246001716 ATP binding site [chemical binding]; other site 420246001717 substrate interface [chemical binding]; other site 420246001718 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 420246001719 Domain of unknown function DUF21; Region: DUF21; pfam01595 420246001720 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 420246001721 Transporter associated domain; Region: CorC_HlyC; smart01091 420246001722 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 420246001723 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 420246001724 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 420246001725 Walker A/P-loop; other site 420246001726 ATP binding site [chemical binding]; other site 420246001727 Q-loop/lid; other site 420246001728 ABC transporter signature motif; other site 420246001729 Walker B; other site 420246001730 D-loop; other site 420246001731 H-loop/switch region; other site 420246001732 TOBE domain; Region: TOBE; pfam03459 420246001733 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 420246001734 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 420246001735 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 420246001736 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 420246001737 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 420246001738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 420246001739 hypothetical protein; Provisional; Region: PRK13676 420246001740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 420246001741 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 420246001742 active site 420246001743 motif I; other site 420246001744 motif II; other site 420246001745 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 420246001746 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 420246001747 YhzD-like protein; Region: YhzD; pfam14120 420246001748 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 420246001749 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 420246001750 Walker A/P-loop; other site 420246001751 ATP binding site [chemical binding]; other site 420246001752 Q-loop/lid; other site 420246001753 ABC transporter signature motif; other site 420246001754 Walker B; other site 420246001755 D-loop; other site 420246001756 H-loop/switch region; other site 420246001757 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 420246001758 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 420246001759 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 420246001760 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 420246001761 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 420246001762 generic binding surface II; other site 420246001763 generic binding surface I; other site 420246001764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246001765 Zn2+ binding site [ion binding]; other site 420246001766 Mg2+ binding site [ion binding]; other site 420246001767 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 420246001768 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 420246001769 homodimer interface [polypeptide binding]; other site 420246001770 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 420246001771 substrate-cofactor binding pocket; other site 420246001772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246001773 catalytic residue [active] 420246001774 transcriptional regulator Hpr; Provisional; Region: PRK13777 420246001775 MarR family; Region: MarR; pfam01047 420246001776 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 420246001777 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 420246001778 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 420246001779 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 420246001780 HIT family signature motif; other site 420246001781 catalytic residue [active] 420246001782 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 420246001783 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 420246001784 Walker A/P-loop; other site 420246001785 ATP binding site [chemical binding]; other site 420246001786 Q-loop/lid; other site 420246001787 ABC transporter signature motif; other site 420246001788 Walker B; other site 420246001789 D-loop; other site 420246001790 H-loop/switch region; other site 420246001791 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 420246001792 Citrate transporter; Region: CitMHS; pfam03600 420246001793 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 420246001794 substrate binding site [chemical binding]; other site 420246001795 active site 420246001796 ferrochelatase; Provisional; Region: PRK12435 420246001797 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 420246001798 C-terminal domain interface [polypeptide binding]; other site 420246001799 active site 420246001800 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 420246001801 active site 420246001802 N-terminal domain interface [polypeptide binding]; other site 420246001803 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 420246001804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 420246001805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246001806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246001807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246001808 Predicted membrane protein [Function unknown]; Region: COG1511 420246001809 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 420246001810 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 420246001811 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 420246001812 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 420246001813 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 420246001814 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 420246001815 acyl-activating enzyme (AAE) consensus motif; other site 420246001816 putative AMP binding site [chemical binding]; other site 420246001817 putative active site [active] 420246001818 putative CoA binding site [chemical binding]; other site 420246001819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 420246001820 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 420246001821 zinc binding site [ion binding]; other site 420246001822 putative ligand binding site [chemical binding]; other site 420246001823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246001824 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 420246001825 TM-ABC transporter signature motif; other site 420246001826 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 420246001827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246001828 Walker A/P-loop; other site 420246001829 ATP binding site [chemical binding]; other site 420246001830 Q-loop/lid; other site 420246001831 ABC transporter signature motif; other site 420246001832 Walker B; other site 420246001833 D-loop; other site 420246001834 H-loop/switch region; other site 420246001835 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 420246001836 homodimer interface [polypeptide binding]; other site 420246001837 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 420246001838 substrate-cofactor binding pocket; other site 420246001839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246001840 catalytic residue [active] 420246001841 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 420246001842 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 420246001843 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 420246001844 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 420246001845 Cu(I) binding site [ion binding]; other site 420246001846 isocitrate lyase; Provisional; Region: PRK15063 420246001847 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 420246001848 tetramer interface [polypeptide binding]; other site 420246001849 active site 420246001850 Mg2+/Mn2+ binding site [ion binding]; other site 420246001851 ComK protein; Region: ComK; pfam06338 420246001852 Uncharacterized conserved protein [Function unknown]; Region: COG0398 420246001853 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 420246001854 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 420246001855 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 420246001856 Catalytic site [active] 420246001857 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 420246001858 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 420246001859 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 420246001860 Part of AAA domain; Region: AAA_19; pfam13245 420246001861 Family description; Region: UvrD_C_2; pfam13538 420246001862 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 420246001863 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 420246001864 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 420246001865 active site 420246001866 metal binding site [ion binding]; metal-binding site 420246001867 DNA binding site [nucleotide binding] 420246001868 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 420246001869 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 420246001870 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 420246001871 Walker A/P-loop; other site 420246001872 ATP binding site [chemical binding]; other site 420246001873 Q-loop/lid; other site 420246001874 ABC transporter signature motif; other site 420246001875 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 420246001876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246001877 ABC transporter signature motif; other site 420246001878 Walker B; other site 420246001879 D-loop; other site 420246001880 H-loop/switch region; other site 420246001881 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 420246001882 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 420246001883 Spore germination protein GerPC; Region: GerPC; pfam10737 420246001884 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 420246001885 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 420246001886 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 420246001887 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 420246001888 Predicted membrane protein [Function unknown]; Region: COG2311 420246001889 Protein of unknown function (DUF418); Region: DUF418; cl12135 420246001890 Protein of unknown function (DUF418); Region: DUF418; pfam04235 420246001891 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 420246001892 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 420246001893 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 420246001894 hypothetical protein; Provisional; Region: PRK13673 420246001895 FIST N domain; Region: FIST; smart00897 420246001896 FIST C domain; Region: FIST_C; pfam10442 420246001897 PAS domain S-box; Region: sensory_box; TIGR00229 420246001898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246001899 putative active site [active] 420246001900 heme pocket [chemical binding]; other site 420246001901 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246001902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246001903 metal binding site [ion binding]; metal-binding site 420246001904 active site 420246001905 I-site; other site 420246001906 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 420246001907 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 420246001908 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 420246001909 active site 420246001910 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 420246001911 dimer interface [polypeptide binding]; other site 420246001912 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 420246001913 Ligand Binding Site [chemical binding]; other site 420246001914 Molecular Tunnel; other site 420246001915 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 420246001916 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 420246001917 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 420246001918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246001919 maltodextrin glucosidase; Provisional; Region: PRK10785 420246001920 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 420246001921 homodimer interface [polypeptide binding]; other site 420246001922 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 420246001923 active site 420246001924 homodimer interface [polypeptide binding]; other site 420246001925 catalytic site [active] 420246001926 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 420246001927 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246001928 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 420246001929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246001930 dimer interface [polypeptide binding]; other site 420246001931 conserved gate region; other site 420246001932 putative PBP binding loops; other site 420246001933 ABC-ATPase subunit interface; other site 420246001934 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246001935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246001936 dimer interface [polypeptide binding]; other site 420246001937 conserved gate region; other site 420246001938 putative PBP binding loops; other site 420246001939 ABC-ATPase subunit interface; other site 420246001940 trehalose synthase; Region: treS_nterm; TIGR02456 420246001941 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 420246001942 active site 420246001943 catalytic site [active] 420246001944 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246001945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246001946 DNA binding site [nucleotide binding] 420246001947 domain linker motif; other site 420246001948 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 420246001949 putative dimerization interface [polypeptide binding]; other site 420246001950 putative ligand binding site [chemical binding]; other site 420246001951 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 420246001952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246001953 Walker A motif; other site 420246001954 ATP binding site [chemical binding]; other site 420246001955 Walker B motif; other site 420246001956 arginine finger; other site 420246001957 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 420246001958 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 420246001959 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 420246001960 tetramer interface [polypeptide binding]; other site 420246001961 TPP-binding site [chemical binding]; other site 420246001962 heterodimer interface [polypeptide binding]; other site 420246001963 phosphorylation loop region [posttranslational modification] 420246001964 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 420246001965 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 420246001966 alpha subunit interface [polypeptide binding]; other site 420246001967 TPP binding site [chemical binding]; other site 420246001968 heterodimer interface [polypeptide binding]; other site 420246001969 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246001970 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 420246001971 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 420246001972 E3 interaction surface; other site 420246001973 lipoyl attachment site [posttranslational modification]; other site 420246001974 e3 binding domain; Region: E3_binding; pfam02817 420246001975 e3 binding domain; Region: E3_binding; pfam02817 420246001976 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 420246001977 short chain dehydrogenase; Provisional; Region: PRK06701 420246001978 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 420246001979 NAD binding site [chemical binding]; other site 420246001980 metal binding site [ion binding]; metal-binding site 420246001981 active site 420246001982 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 420246001983 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 420246001984 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 420246001985 substrate binding pocket [chemical binding]; other site 420246001986 dimer interface [polypeptide binding]; other site 420246001987 inhibitor binding site; inhibition site 420246001988 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 420246001989 B12 binding site [chemical binding]; other site 420246001990 cobalt ligand [ion binding]; other site 420246001991 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 420246001992 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 420246001993 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 420246001994 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 420246001995 FAD binding site [chemical binding]; other site 420246001996 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 420246001997 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 420246001998 Walker A/P-loop; other site 420246001999 ATP binding site [chemical binding]; other site 420246002000 Q-loop/lid; other site 420246002001 ABC transporter signature motif; other site 420246002002 Walker B; other site 420246002003 D-loop; other site 420246002004 H-loop/switch region; other site 420246002005 TOBE domain; Region: TOBE_2; pfam08402 420246002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 420246002007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002008 ABC-ATPase subunit interface; other site 420246002009 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 420246002010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002011 dimer interface [polypeptide binding]; other site 420246002012 conserved gate region; other site 420246002013 putative PBP binding loops; other site 420246002014 ABC-ATPase subunit interface; other site 420246002015 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 420246002016 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 420246002017 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 420246002018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 420246002019 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 420246002020 Transposase, Mutator family; Region: Transposase_mut; pfam00872 420246002021 MULE transposase domain; Region: MULE; pfam10551 420246002022 EDD domain protein, DegV family; Region: DegV; TIGR00762 420246002023 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 420246002024 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 420246002025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246002026 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 420246002027 active site 420246002028 motif I; other site 420246002029 motif II; other site 420246002030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246002031 esterase; Provisional; Region: PRK10566 420246002032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 420246002033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246002034 dimerization interface [polypeptide binding]; other site 420246002035 putative DNA binding site [nucleotide binding]; other site 420246002036 putative Zn2+ binding site [ion binding]; other site 420246002037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 420246002038 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 420246002039 metal-binding site [ion binding] 420246002040 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 420246002041 Soluble P-type ATPase [General function prediction only]; Region: COG4087 420246002042 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 420246002043 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 420246002044 CPxP motif; other site 420246002045 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 420246002046 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 420246002047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 420246002048 ligand binding site [chemical binding]; other site 420246002049 flexible hinge region; other site 420246002050 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 420246002051 non-specific DNA interactions [nucleotide binding]; other site 420246002052 DNA binding site [nucleotide binding] 420246002053 sequence specific DNA binding site [nucleotide binding]; other site 420246002054 putative cAMP binding site [chemical binding]; other site 420246002055 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 420246002056 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 420246002057 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 420246002058 D-pathway; other site 420246002059 Low-spin heme binding site [chemical binding]; other site 420246002060 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 420246002061 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 420246002062 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 420246002063 GTP binding site; other site 420246002064 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 420246002065 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246002066 FeS/SAM binding site; other site 420246002067 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 420246002068 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 420246002069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246002070 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 420246002071 putative substrate translocation pore; other site 420246002072 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 420246002073 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 420246002074 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 420246002075 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 420246002076 PYR/PP interface [polypeptide binding]; other site 420246002077 dimer interface [polypeptide binding]; other site 420246002078 TPP binding site [chemical binding]; other site 420246002079 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 420246002080 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 420246002081 TPP-binding site [chemical binding]; other site 420246002082 dimer interface [polypeptide binding]; other site 420246002083 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 420246002084 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 420246002085 [4Fe-4S] binding site [ion binding]; other site 420246002086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246002087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246002088 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246002089 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 420246002090 molybdopterin cofactor binding site; other site 420246002091 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 420246002092 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 420246002093 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 420246002094 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 420246002095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 420246002096 ligand binding site [chemical binding]; other site 420246002097 flexible hinge region; other site 420246002098 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 420246002099 putative switch regulator; other site 420246002100 non-specific DNA interactions [nucleotide binding]; other site 420246002101 DNA binding site [nucleotide binding] 420246002102 sequence specific DNA binding site [nucleotide binding]; other site 420246002103 putative cAMP binding site [chemical binding]; other site 420246002104 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 420246002105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002106 putative PBP binding loops; other site 420246002107 dimer interface [polypeptide binding]; other site 420246002108 ABC-ATPase subunit interface; other site 420246002109 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 420246002110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246002111 FeS/SAM binding site; other site 420246002112 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 420246002113 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 420246002114 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 420246002115 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 420246002116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 420246002117 dimer interface [polypeptide binding]; other site 420246002118 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 420246002119 putative CheW interface [polypeptide binding]; other site 420246002120 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 420246002121 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 420246002122 dimer interface [polypeptide binding]; other site 420246002123 putative functional site; other site 420246002124 putative MPT binding site; other site 420246002125 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 420246002126 Walker A motif; other site 420246002127 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 420246002128 MoaE homodimer interface [polypeptide binding]; other site 420246002129 MoaD interaction [polypeptide binding]; other site 420246002130 active site residues [active] 420246002131 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 420246002132 MoaE interaction surface [polypeptide binding]; other site 420246002133 MoeB interaction surface [polypeptide binding]; other site 420246002134 thiocarboxylated glycine; other site 420246002135 YwiC-like protein; Region: YwiC; pfam14256 420246002136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246002137 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246002138 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 420246002139 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 420246002140 ligand binding site [chemical binding]; other site 420246002141 flexible hinge region; other site 420246002142 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 420246002143 putative switch regulator; other site 420246002144 non-specific DNA interactions [nucleotide binding]; other site 420246002145 DNA binding site [nucleotide binding] 420246002146 sequence specific DNA binding site [nucleotide binding]; other site 420246002147 putative cAMP binding site [chemical binding]; other site 420246002148 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 420246002149 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 420246002150 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 420246002151 heterotetramer interface [polypeptide binding]; other site 420246002152 active site pocket [active] 420246002153 cleavage site 420246002154 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 420246002155 nucleotide binding site [chemical binding]; other site 420246002156 N-acetyl-L-glutamate binding site [chemical binding]; other site 420246002157 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 420246002158 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 420246002159 inhibitor-cofactor binding pocket; inhibition site 420246002160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246002161 catalytic residue [active] 420246002162 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 420246002163 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 420246002164 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 420246002165 catalytic site [active] 420246002166 subunit interface [polypeptide binding]; other site 420246002167 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 420246002168 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246002169 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 420246002170 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 420246002171 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246002172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 420246002173 ornithine carbamoyltransferase; Provisional; Region: PRK00779 420246002174 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 420246002175 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 420246002176 YjzC-like protein; Region: YjzC; pfam14168 420246002177 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 420246002178 Clp amino terminal domain; Region: Clp_N; pfam02861 420246002179 Clp amino terminal domain; Region: Clp_N; pfam02861 420246002180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246002181 Walker A motif; other site 420246002182 ATP binding site [chemical binding]; other site 420246002183 Walker B motif; other site 420246002184 arginine finger; other site 420246002185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246002186 Walker A motif; other site 420246002187 ATP binding site [chemical binding]; other site 420246002188 Walker B motif; other site 420246002189 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 420246002190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246002191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246002192 MMPL family; Region: MMPL; pfam03176 420246002193 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 420246002194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 420246002195 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 420246002196 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 420246002197 dimer interface [polypeptide binding]; other site 420246002198 active site 420246002199 CoA binding pocket [chemical binding]; other site 420246002200 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 420246002201 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 420246002202 dimer interface [polypeptide binding]; other site 420246002203 active site 420246002204 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 420246002205 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 420246002206 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 420246002207 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 420246002208 active site 420246002209 HIGH motif; other site 420246002210 dimer interface [polypeptide binding]; other site 420246002211 KMSKS motif; other site 420246002212 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 420246002213 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 420246002214 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 420246002215 peptide binding site [polypeptide binding]; other site 420246002216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 420246002217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002218 dimer interface [polypeptide binding]; other site 420246002219 conserved gate region; other site 420246002220 putative PBP binding loops; other site 420246002221 ABC-ATPase subunit interface; other site 420246002222 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 420246002223 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 420246002224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002225 dimer interface [polypeptide binding]; other site 420246002226 conserved gate region; other site 420246002227 putative PBP binding loops; other site 420246002228 ABC-ATPase subunit interface; other site 420246002229 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 420246002230 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246002231 Walker A/P-loop; other site 420246002232 ATP binding site [chemical binding]; other site 420246002233 Q-loop/lid; other site 420246002234 ABC transporter signature motif; other site 420246002235 Walker B; other site 420246002236 D-loop; other site 420246002237 H-loop/switch region; other site 420246002238 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246002239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 420246002240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246002241 Walker A/P-loop; other site 420246002242 ATP binding site [chemical binding]; other site 420246002243 Q-loop/lid; other site 420246002244 ABC transporter signature motif; other site 420246002245 Walker B; other site 420246002246 D-loop; other site 420246002247 H-loop/switch region; other site 420246002248 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 420246002249 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 420246002250 ArsC family; Region: ArsC; pfam03960 420246002251 putative catalytic residues [active] 420246002252 thiol/disulfide switch; other site 420246002253 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 420246002254 adaptor protein; Provisional; Region: PRK02315 420246002255 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 420246002256 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 420246002257 putative active site [active] 420246002258 catalytic site [active] 420246002259 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 420246002260 putative active site [active] 420246002261 catalytic site [active] 420246002262 Competence protein CoiA-like family; Region: CoiA; cl11541 420246002263 oligoendopeptidase F; Region: pepF; TIGR00181 420246002264 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 420246002265 active site 420246002266 Zn binding site [ion binding]; other site 420246002267 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 420246002268 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 420246002269 catalytic residues [active] 420246002270 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 420246002271 apolar tunnel; other site 420246002272 heme binding site [chemical binding]; other site 420246002273 dimerization interface [polypeptide binding]; other site 420246002274 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 420246002275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 420246002276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 420246002277 catalytic residue [active] 420246002278 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 420246002279 putative active site [active] 420246002280 putative metal binding residues [ion binding]; other site 420246002281 signature motif; other site 420246002282 putative triphosphate binding site [ion binding]; other site 420246002283 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 420246002284 synthetase active site [active] 420246002285 NTP binding site [chemical binding]; other site 420246002286 metal binding site [ion binding]; metal-binding site 420246002287 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 420246002288 ATP-NAD kinase; Region: NAD_kinase; pfam01513 420246002289 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 420246002290 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 420246002291 active site 420246002292 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 420246002293 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 420246002294 active site 420246002295 metal binding site [ion binding]; metal-binding site 420246002296 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 420246002297 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 420246002298 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 420246002299 NAD binding site [chemical binding]; other site 420246002300 homotetramer interface [polypeptide binding]; other site 420246002301 homodimer interface [polypeptide binding]; other site 420246002302 substrate binding site [chemical binding]; other site 420246002303 active site 420246002304 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 420246002305 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 420246002306 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 420246002307 active site 420246002308 ATP binding site [chemical binding]; other site 420246002309 spore coat protein YutH; Region: spore_yutH; TIGR02905 420246002310 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 420246002311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246002312 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 420246002313 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 420246002314 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 420246002315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246002316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 420246002317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246002318 NAD(P) binding site [chemical binding]; other site 420246002319 active site 420246002320 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 420246002321 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 420246002322 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 420246002323 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 420246002324 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 420246002325 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 420246002326 Bacteriophage holin; Region: Phage_holin_1; cl02344 420246002327 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 420246002328 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 420246002329 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 420246002330 stage V sporulation protein AD; Provisional; Region: PRK12404 420246002331 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 420246002332 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 420246002333 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 420246002334 Predicted membrane protein [Function unknown]; Region: COG2323 420246002335 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 420246002336 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 420246002337 catalytic residues [active] 420246002338 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 420246002339 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 420246002340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246002341 Coenzyme A binding pocket [chemical binding]; other site 420246002342 hypothetical protein; Provisional; Region: PRK13679 420246002343 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 420246002344 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 420246002345 Putative esterase; Region: Esterase; pfam00756 420246002346 cystathionine gamma-synthase; Reviewed; Region: PRK08247 420246002347 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 420246002348 homodimer interface [polypeptide binding]; other site 420246002349 substrate-cofactor binding pocket; other site 420246002350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246002351 catalytic residue [active] 420246002352 cystathionine beta-lyase; Provisional; Region: PRK08064 420246002353 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 420246002354 homodimer interface [polypeptide binding]; other site 420246002355 substrate-cofactor binding pocket; other site 420246002356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246002357 catalytic residue [active] 420246002358 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 420246002359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 420246002360 active site 420246002361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246002362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 420246002363 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 420246002364 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 420246002365 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 420246002366 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 420246002367 Int/Topo IB signature motif; other site 420246002368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246002369 non-specific DNA binding site [nucleotide binding]; other site 420246002370 salt bridge; other site 420246002371 sequence-specific DNA binding site [nucleotide binding]; other site 420246002372 putative transposase OrfB; Reviewed; Region: PHA02517 420246002373 HTH-like domain; Region: HTH_21; pfam13276 420246002374 Integrase core domain; Region: rve; pfam00665 420246002375 Integrase core domain; Region: rve_3; pfam13683 420246002376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246002377 Transposase; Region: HTH_Tnp_1; pfam01527 420246002378 HTH-like domain; Region: HTH_21; pfam13276 420246002379 Integrase core domain; Region: rve; pfam00665 420246002380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246002381 AAA domain; Region: AAA_23; pfam13476 420246002382 Walker A/P-loop; other site 420246002383 ATP binding site [chemical binding]; other site 420246002384 Q-loop/lid; other site 420246002385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246002386 ABC transporter signature motif; other site 420246002387 Walker B; other site 420246002388 D-loop; other site 420246002389 H-loop/switch region; other site 420246002390 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 420246002391 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 420246002392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246002393 ATP binding site [chemical binding]; other site 420246002394 putative Mg++ binding site [ion binding]; other site 420246002395 HsdM N-terminal domain; Region: HsdM_N; pfam12161 420246002396 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 420246002397 Methyltransferase domain; Region: Methyltransf_26; pfam13659 420246002398 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 420246002399 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 420246002400 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 420246002401 Transposase, Mutator family; Region: Transposase_mut; pfam00872 420246002402 MULE transposase domain; Region: MULE; pfam10551 420246002403 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 420246002404 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 420246002405 Magnesium ion binding site [ion binding]; other site 420246002406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246002407 Transposase; Region: HTH_Tnp_1; pfam01527 420246002408 putative transposase OrfB; Reviewed; Region: PHA02517 420246002409 HTH-like domain; Region: HTH_21; pfam13276 420246002410 Integrase core domain; Region: rve; pfam00665 420246002411 Integrase core domain; Region: rve_3; pfam13683 420246002412 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 420246002413 Transposase, Mutator family; Region: Transposase_mut; pfam00872 420246002414 Predicted membrane protein [Function unknown]; Region: COG3428 420246002415 Bacterial PH domain; Region: DUF304; pfam03703 420246002416 Bacterial PH domain; Region: DUF304; pfam03703 420246002417 Bacterial PH domain; Region: DUF304; pfam03703 420246002418 Uncharacterized conserved protein [Function unknown]; Region: COG3402 420246002419 Predicted transcriptional regulators [Transcription]; Region: COG1733 420246002420 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 420246002421 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246002422 Transposase; Region: HTH_Tnp_1; pfam01527 420246002423 HTH-like domain; Region: HTH_21; pfam13276 420246002424 Integrase core domain; Region: rve; pfam00665 420246002425 Integrase core domain; Region: rve_3; pfam13683 420246002426 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 420246002427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246002428 putative substrate translocation pore; other site 420246002429 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 420246002430 active site 420246002431 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 420246002432 catalytic tetrad [active] 420246002433 Predicted membrane protein [Function unknown]; Region: COG2259 420246002434 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 420246002435 Ligand binding site [chemical binding]; other site 420246002436 Electron transfer flavoprotein domain; Region: ETF; pfam01012 420246002437 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 420246002438 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 420246002439 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 420246002440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246002441 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246002442 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 420246002443 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 420246002444 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 420246002445 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 420246002446 active site 420246002447 dimer interface [polypeptide binding]; other site 420246002448 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 420246002449 Ligand Binding Site [chemical binding]; other site 420246002450 Molecular Tunnel; other site 420246002451 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246002452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 420246002453 dimerization interface [polypeptide binding]; other site 420246002454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246002455 dimer interface [polypeptide binding]; other site 420246002456 phosphorylation site [posttranslational modification] 420246002457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246002458 ATP binding site [chemical binding]; other site 420246002459 Mg2+ binding site [ion binding]; other site 420246002460 G-X-G motif; other site 420246002461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246002462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246002463 active site 420246002464 phosphorylation site [posttranslational modification] 420246002465 intermolecular recognition site; other site 420246002466 dimerization interface [polypeptide binding]; other site 420246002467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246002468 DNA binding site [nucleotide binding] 420246002469 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 420246002470 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 420246002471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246002472 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 420246002473 Walker A/P-loop; other site 420246002474 ATP binding site [chemical binding]; other site 420246002475 Q-loop/lid; other site 420246002476 ABC transporter signature motif; other site 420246002477 Walker B; other site 420246002478 D-loop; other site 420246002479 H-loop/switch region; other site 420246002480 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 420246002481 Class I ribonucleotide reductase; Region: RNR_I; cd01679 420246002482 active site 420246002483 dimer interface [polypeptide binding]; other site 420246002484 catalytic residues [active] 420246002485 effector binding site; other site 420246002486 R2 peptide binding site; other site 420246002487 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 420246002488 dimer interface [polypeptide binding]; other site 420246002489 putative radical transfer pathway; other site 420246002490 diiron center [ion binding]; other site 420246002491 tyrosyl radical; other site 420246002492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246002493 TPR motif; other site 420246002494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 420246002495 binding surface 420246002496 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 420246002497 putative active site pocket [active] 420246002498 dimerization interface [polypeptide binding]; other site 420246002499 putative catalytic residue [active] 420246002500 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 420246002501 putative active site pocket [active] 420246002502 dimerization interface [polypeptide binding]; other site 420246002503 putative catalytic residue [active] 420246002504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246002505 ABC transporter signature motif; other site 420246002506 Walker B; other site 420246002507 D-loop; other site 420246002508 hypothetical protein; Provisional; Region: PRK04164 420246002509 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 420246002510 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 420246002511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246002512 Zn2+ binding site [ion binding]; other site 420246002513 Mg2+ binding site [ion binding]; other site 420246002514 metabolite-proton symporter; Region: 2A0106; TIGR00883 420246002515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246002516 putative substrate translocation pore; other site 420246002517 ornithine cyclodeaminase; Validated; Region: PRK08618 420246002518 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 420246002519 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 420246002520 FAD binding domain; Region: FAD_binding_4; pfam01565 420246002521 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 420246002522 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 420246002523 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 420246002524 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 420246002525 Uncharacterized conserved protein [Function unknown]; Region: COG2966 420246002526 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 420246002527 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 420246002528 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 420246002529 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 420246002530 amidohydrolase; Region: amidohydrolases; TIGR01891 420246002531 metal binding site [ion binding]; metal-binding site 420246002532 putative dimer interface [polypeptide binding]; other site 420246002533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246002534 Coenzyme A binding pocket [chemical binding]; other site 420246002535 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 420246002536 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 420246002537 active site 420246002538 octamer interface [polypeptide binding]; other site 420246002539 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 420246002540 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 420246002541 Na binding site [ion binding]; other site 420246002542 Protein of unknown function, DUF485; Region: DUF485; pfam04341 420246002543 amino acid transporter; Region: 2A0306; TIGR00909 420246002544 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 420246002545 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 420246002546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246002547 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 420246002548 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 420246002549 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246002550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246002551 DNA binding site [nucleotide binding] 420246002552 domain linker motif; other site 420246002553 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 420246002554 dimerization interface [polypeptide binding]; other site 420246002555 ligand binding site [chemical binding]; other site 420246002556 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 420246002557 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 420246002558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246002559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002561 dimer interface [polypeptide binding]; other site 420246002562 conserved gate region; other site 420246002563 putative PBP binding loops; other site 420246002564 ABC-ATPase subunit interface; other site 420246002565 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246002567 dimer interface [polypeptide binding]; other site 420246002568 conserved gate region; other site 420246002569 putative PBP binding loops; other site 420246002570 ABC-ATPase subunit interface; other site 420246002571 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 420246002572 Radical SAM superfamily; Region: Radical_SAM; pfam04055 420246002573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246002574 FeS/SAM binding site; other site 420246002575 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 420246002576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246002577 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 420246002578 putative active site [active] 420246002579 heme pocket [chemical binding]; other site 420246002580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246002581 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 420246002582 putative active site [active] 420246002583 heme pocket [chemical binding]; other site 420246002584 PAS domain; Region: PAS; smart00091 420246002585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 420246002586 putative active site [active] 420246002587 heme pocket [chemical binding]; other site 420246002588 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 420246002589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246002590 putative active site [active] 420246002591 heme pocket [chemical binding]; other site 420246002592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246002593 dimer interface [polypeptide binding]; other site 420246002594 phosphorylation site [posttranslational modification] 420246002595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246002596 ATP binding site [chemical binding]; other site 420246002597 Mg2+ binding site [ion binding]; other site 420246002598 G-X-G motif; other site 420246002599 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 420246002600 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 420246002601 DNA binding site [nucleotide binding] 420246002602 active site 420246002603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246002604 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 420246002605 TM-ABC transporter signature motif; other site 420246002606 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 420246002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246002608 Walker A/P-loop; other site 420246002609 ATP binding site [chemical binding]; other site 420246002610 Q-loop/lid; other site 420246002611 ABC transporter signature motif; other site 420246002612 Walker B; other site 420246002613 D-loop; other site 420246002614 H-loop/switch region; other site 420246002615 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 420246002616 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 420246002617 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 420246002618 putative ligand binding site [chemical binding]; other site 420246002619 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 420246002620 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 420246002621 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 420246002622 Phosphotransferase enzyme family; Region: APH; pfam01636 420246002623 Predicted amidohydrolase [General function prediction only]; Region: COG0388 420246002624 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 420246002625 putative active site [active] 420246002626 catalytic triad [active] 420246002627 putative dimer interface [polypeptide binding]; other site 420246002628 transaminase; Reviewed; Region: PRK08068 420246002629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246002630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246002631 homodimer interface [polypeptide binding]; other site 420246002632 catalytic residue [active] 420246002633 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 420246002634 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 420246002635 dimer interface [polypeptide binding]; other site 420246002636 active site 420246002637 catalytic residue [active] 420246002638 metal binding site [ion binding]; metal-binding site 420246002639 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 420246002640 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246002641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246002642 motif II; other site 420246002643 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 420246002644 intersubunit interface [polypeptide binding]; other site 420246002645 active site 420246002646 Zn2+ binding site [ion binding]; other site 420246002647 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 420246002648 Cupin domain; Region: Cupin_2; cl17218 420246002649 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 420246002650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 420246002651 MarR family; Region: MarR; pfam01047 420246002652 MarR family; Region: MarR_2; cl17246 420246002653 Propanediol utilisation protein PduL; Region: PduL; pfam06130 420246002654 short chain dehydrogenase; Provisional; Region: PRK08309 420246002655 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 420246002656 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 420246002657 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 420246002658 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 420246002659 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 420246002660 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 420246002661 active site 420246002662 Zn binding site [ion binding]; other site 420246002663 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 420246002664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246002665 Coenzyme A binding pocket [chemical binding]; other site 420246002666 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 420246002667 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 420246002668 Walker A/P-loop; other site 420246002669 ATP binding site [chemical binding]; other site 420246002670 Q-loop/lid; other site 420246002671 ABC transporter signature motif; other site 420246002672 Walker B; other site 420246002673 D-loop; other site 420246002674 H-loop/switch region; other site 420246002675 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 420246002676 ABC-2 type transporter; Region: ABC2_membrane; cl17235 420246002677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246002678 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246002679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246002680 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 420246002681 Walker A motif; other site 420246002682 ATP binding site [chemical binding]; other site 420246002683 Walker B motif; other site 420246002684 arginine finger; other site 420246002685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246002686 Walker A motif; other site 420246002687 ATP binding site [chemical binding]; other site 420246002688 Walker B motif; other site 420246002689 arginine finger; other site 420246002690 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 420246002691 YtkA-like; Region: YtkA; pfam13115 420246002692 YtkA-like; Region: YtkA; pfam13115 420246002693 Uncharacterized membrane protein [Function unknown]; Region: COG3949 420246002694 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 420246002695 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 420246002696 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 420246002697 Spore germination protein; Region: Spore_permease; pfam03845 420246002698 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 420246002699 Ligand Binding Site [chemical binding]; other site 420246002700 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 420246002701 active site 420246002702 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 420246002703 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 420246002704 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 420246002705 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 420246002706 NADH(P)-binding; Region: NAD_binding_10; pfam13460 420246002707 NAD binding site [chemical binding]; other site 420246002708 active site 420246002709 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 420246002710 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 420246002711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246002712 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 420246002713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 420246002714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246002715 NAD(P) binding site [chemical binding]; other site 420246002716 active site 420246002717 YueH-like protein; Region: YueH; pfam14166 420246002718 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 420246002719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246002720 putative active site [active] 420246002721 heme pocket [chemical binding]; other site 420246002722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246002723 dimer interface [polypeptide binding]; other site 420246002724 phosphorylation site [posttranslational modification] 420246002725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246002726 ATP binding site [chemical binding]; other site 420246002727 Mg2+ binding site [ion binding]; other site 420246002728 G-X-G motif; other site 420246002729 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 420246002730 dimer interface [polypeptide binding]; other site 420246002731 FMN binding site [chemical binding]; other site 420246002732 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 420246002733 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 420246002734 transcriptional antiterminator BglG; Provisional; Region: PRK09772 420246002735 CAT RNA binding domain; Region: CAT_RBD; smart01061 420246002736 PRD domain; Region: PRD; pfam00874 420246002737 PRD domain; Region: PRD; pfam00874 420246002738 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 420246002739 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 420246002740 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 420246002741 active site turn [active] 420246002742 phosphorylation site [posttranslational modification] 420246002743 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 420246002744 HPr interaction site; other site 420246002745 glycerol kinase (GK) interaction site [polypeptide binding]; other site 420246002746 active site 420246002747 phosphorylation site [posttranslational modification] 420246002748 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 420246002749 dimerization domain swap beta strand [polypeptide binding]; other site 420246002750 regulatory protein interface [polypeptide binding]; other site 420246002751 active site 420246002752 regulatory phosphorylation site [posttranslational modification]; other site 420246002753 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 420246002754 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 420246002755 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 420246002756 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 420246002757 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 420246002758 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 420246002759 Cache domain; Region: Cache_1; pfam02743 420246002760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246002761 dimerization interface [polypeptide binding]; other site 420246002762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 420246002763 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 420246002764 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 420246002765 dimer interface [polypeptide binding]; other site 420246002766 putative CheW interface [polypeptide binding]; other site 420246002767 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 420246002768 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 420246002769 TPP-binding site [chemical binding]; other site 420246002770 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 420246002771 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 420246002772 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 420246002773 E3 interaction surface; other site 420246002774 lipoyl attachment site [posttranslational modification]; other site 420246002775 e3 binding domain; Region: E3_binding; pfam02817 420246002776 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 420246002777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 420246002778 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 420246002779 putative NAD(P) binding site [chemical binding]; other site 420246002780 putative active site [active] 420246002781 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 420246002782 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 420246002783 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246002784 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 420246002785 FAD binding site [chemical binding]; other site 420246002786 substrate binding site [chemical binding]; other site 420246002787 catalytic base [active] 420246002788 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 420246002789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246002790 NAD(P) binding site [chemical binding]; other site 420246002791 active site 420246002792 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 420246002793 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 420246002794 acyl-activating enzyme (AAE) consensus motif; other site 420246002795 putative AMP binding site [chemical binding]; other site 420246002796 putative active site [active] 420246002797 putative CoA binding site [chemical binding]; other site 420246002798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246002799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246002800 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 420246002801 Phosphotransferase enzyme family; Region: APH; pfam01636 420246002802 putative active site [active] 420246002803 putative substrate binding site [chemical binding]; other site 420246002804 ATP binding site [chemical binding]; other site 420246002805 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 420246002806 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 420246002807 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 420246002808 NADP binding site [chemical binding]; other site 420246002809 dimer interface [polypeptide binding]; other site 420246002810 aminotransferase A; Validated; Region: PRK07683 420246002811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246002812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246002813 homodimer interface [polypeptide binding]; other site 420246002814 catalytic residue [active] 420246002815 IDEAL domain; Region: IDEAL; pfam08858 420246002816 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 420246002817 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 420246002818 oligomer interface [polypeptide binding]; other site 420246002819 metal binding site [ion binding]; metal-binding site 420246002820 metal binding site [ion binding]; metal-binding site 420246002821 putative Cl binding site [ion binding]; other site 420246002822 aspartate ring; other site 420246002823 basic sphincter; other site 420246002824 hydrophobic gate; other site 420246002825 periplasmic entrance; other site 420246002826 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 420246002827 active site 420246002828 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 420246002829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246002830 active site 420246002831 phosphorylation site [posttranslational modification] 420246002832 intermolecular recognition site; other site 420246002833 dimerization interface [polypeptide binding]; other site 420246002834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246002835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246002836 metal binding site [ion binding]; metal-binding site 420246002837 active site 420246002838 I-site; other site 420246002839 YkyB-like protein; Region: YkyB; pfam14177 420246002840 phosphodiesterase YaeI; Provisional; Region: PRK11340 420246002841 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 420246002842 putative active site [active] 420246002843 putative metal binding site [ion binding]; other site 420246002844 short chain dehydrogenase; Provisional; Region: PRK07677 420246002845 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 420246002846 NAD(P) binding site [chemical binding]; other site 420246002847 substrate binding site [chemical binding]; other site 420246002848 homotetramer interface [polypeptide binding]; other site 420246002849 active site 420246002850 homodimer interface [polypeptide binding]; other site 420246002851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 420246002852 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 420246002853 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 420246002854 FOG: CBS domain [General function prediction only]; Region: COG0517 420246002855 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 420246002856 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 420246002857 hypothetical protein; Provisional; Region: PRK10621 420246002858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 420246002859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 420246002860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 420246002861 dimerization interface [polypeptide binding]; other site 420246002862 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 420246002863 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 420246002864 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 420246002865 active site 420246002866 trimer interface [polypeptide binding]; other site 420246002867 substrate binding site [chemical binding]; other site 420246002868 CoA binding site [chemical binding]; other site 420246002869 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 420246002870 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 420246002871 metal binding site [ion binding]; metal-binding site 420246002872 putative dimer interface [polypeptide binding]; other site 420246002873 hypothetical protein; Provisional; Region: PRK03094 420246002874 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 420246002875 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 420246002876 dimer interface [polypeptide binding]; other site 420246002877 decamer (pentamer of dimers) interface [polypeptide binding]; other site 420246002878 catalytic triad [active] 420246002879 peroxidatic and resolving cysteines [active] 420246002880 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 420246002881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 420246002882 catalytic residues [active] 420246002883 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 420246002884 TrkA-N domain; Region: TrkA_N; pfam02254 420246002885 TrkA-C domain; Region: TrkA_C; pfam02080 420246002886 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 420246002887 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246002888 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 420246002889 hypothetical protein; Provisional; Region: PRK13667 420246002890 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 420246002891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246002892 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 420246002893 active site 420246002894 catalytic residues [active] 420246002895 metal binding site [ion binding]; metal-binding site 420246002896 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 420246002897 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 420246002898 TPP-binding site [chemical binding]; other site 420246002899 tetramer interface [polypeptide binding]; other site 420246002900 heterodimer interface [polypeptide binding]; other site 420246002901 phosphorylation loop region [posttranslational modification] 420246002902 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 420246002903 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 420246002904 alpha subunit interface [polypeptide binding]; other site 420246002905 TPP binding site [chemical binding]; other site 420246002906 heterodimer interface [polypeptide binding]; other site 420246002907 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246002908 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 420246002909 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 420246002910 E3 interaction surface; other site 420246002911 lipoyl attachment site [posttranslational modification]; other site 420246002912 e3 binding domain; Region: E3_binding; pfam02817 420246002913 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 420246002914 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 420246002915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246002916 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 420246002917 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 420246002918 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 420246002919 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 420246002920 homodimer interface [polypeptide binding]; other site 420246002921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246002922 catalytic residue [active] 420246002923 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 420246002924 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 420246002925 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 420246002926 FMN binding site [chemical binding]; other site 420246002927 substrate binding site [chemical binding]; other site 420246002928 putative catalytic residue [active] 420246002929 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 420246002930 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 420246002931 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 420246002932 active site 420246002933 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 420246002934 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 420246002935 G1 box; other site 420246002936 putative GEF interaction site [polypeptide binding]; other site 420246002937 GTP/Mg2+ binding site [chemical binding]; other site 420246002938 Switch I region; other site 420246002939 G2 box; other site 420246002940 G3 box; other site 420246002941 Switch II region; other site 420246002942 G4 box; other site 420246002943 G5 box; other site 420246002944 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 420246002945 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 420246002946 YlaH-like protein; Region: YlaH; pfam14036 420246002947 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 420246002948 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 420246002949 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 420246002950 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 420246002951 putative active site [active] 420246002952 PhoH-like protein; Region: PhoH; pfam02562 420246002953 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 420246002954 hypothetical protein; Provisional; Region: PRK13666 420246002955 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 420246002956 pyruvate carboxylase; Reviewed; Region: PRK12999 420246002957 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246002958 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 420246002959 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 420246002960 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 420246002961 active site 420246002962 catalytic residues [active] 420246002963 metal binding site [ion binding]; metal-binding site 420246002964 homodimer binding site [polypeptide binding]; other site 420246002965 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 420246002966 carboxyltransferase (CT) interaction site; other site 420246002967 biotinylation site [posttranslational modification]; other site 420246002968 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 420246002969 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 420246002970 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 420246002971 UbiA prenyltransferase family; Region: UbiA; pfam01040 420246002972 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 420246002973 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 420246002974 Cytochrome c; Region: Cytochrom_C; pfam00034 420246002975 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 420246002976 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 420246002977 D-pathway; other site 420246002978 Putative ubiquinol binding site [chemical binding]; other site 420246002979 Low-spin heme (heme b) binding site [chemical binding]; other site 420246002980 Putative water exit pathway; other site 420246002981 Binuclear center (heme o3/CuB) [ion binding]; other site 420246002982 K-pathway; other site 420246002983 Putative proton exit pathway; other site 420246002984 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 420246002985 Subunit I/III interface [polypeptide binding]; other site 420246002986 Subunit III/IV interface [polypeptide binding]; other site 420246002987 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 420246002988 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 420246002989 Protein of unknown function (DUF420); Region: DUF420; pfam04238 420246002990 Asp23 family; Region: Asp23; cl00574 420246002991 YugN-like family; Region: YugN; pfam08868 420246002992 FOG: CBS domain [General function prediction only]; Region: COG0517 420246002993 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 420246002994 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 420246002995 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 420246002996 Putative coat protein; Region: YlbD_coat; pfam14071 420246002997 YlbE-like protein; Region: YlbE; pfam14003 420246002998 Protein of unknown function (DUF964); Region: DUF964; pfam06133 420246002999 hypothetical protein; Provisional; Region: PRK02886 420246003000 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 420246003001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246003002 S-adenosylmethionine binding site [chemical binding]; other site 420246003003 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 420246003004 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 420246003005 active site 420246003006 (T/H)XGH motif; other site 420246003007 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 420246003008 Nucleoside recognition; Region: Gate; pfam07670 420246003009 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 420246003010 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 420246003011 active site 420246003012 nucleophile elbow; other site 420246003013 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 420246003014 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 420246003015 protein binding site [polypeptide binding]; other site 420246003016 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 420246003017 hypothetical protein; Provisional; Region: PRK13670 420246003018 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 420246003019 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 420246003020 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 420246003021 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 420246003022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246003023 substrate binding site [chemical binding]; other site 420246003024 oxyanion hole (OAH) forming residues; other site 420246003025 trimer interface [polypeptide binding]; other site 420246003026 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 420246003027 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 420246003028 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 420246003029 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 420246003030 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 420246003031 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 420246003032 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 420246003033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 420246003034 MraW methylase family; Region: Methyltransf_5; pfam01795 420246003035 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 420246003036 Cell division protein FtsL; Region: FtsL; cl11433 420246003037 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 420246003038 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 420246003039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 420246003040 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 420246003041 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 420246003042 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 420246003043 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 420246003044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 420246003045 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 420246003046 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 420246003047 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 420246003048 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 420246003049 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 420246003050 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 420246003051 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 420246003052 Mg++ binding site [ion binding]; other site 420246003053 putative catalytic motif [active] 420246003054 putative substrate binding site [chemical binding]; other site 420246003055 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 420246003056 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 420246003057 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 420246003058 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 420246003059 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 420246003060 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 420246003061 Cell division protein FtsQ; Region: FtsQ; pfam03799 420246003062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 420246003063 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 420246003064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 420246003065 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 420246003066 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 420246003067 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 420246003068 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 420246003069 nucleotide binding site [chemical binding]; other site 420246003070 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 420246003071 Cell division protein FtsA; Region: FtsA; pfam14450 420246003072 cell division protein FtsZ; Validated; Region: PRK09330 420246003073 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 420246003074 nucleotide binding site [chemical binding]; other site 420246003075 SulA interaction site; other site 420246003076 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 420246003077 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 420246003078 sporulation sigma factor SigE; Reviewed; Region: PRK08301 420246003079 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246003080 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246003081 DNA binding residues [nucleotide binding] 420246003082 sporulation sigma factor SigG; Reviewed; Region: PRK08215 420246003083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246003084 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 420246003085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246003086 DNA binding residues [nucleotide binding] 420246003087 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 420246003088 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 420246003089 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 420246003090 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 420246003091 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 420246003092 catalytic residue [active] 420246003093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 420246003094 YGGT family; Region: YGGT; pfam02325 420246003095 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 420246003096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246003097 RNA binding surface [nucleotide binding]; other site 420246003098 DivIVA protein; Region: DivIVA; pfam05103 420246003099 DivIVA domain; Region: DivI1A_domain; TIGR03544 420246003100 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 420246003101 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 420246003102 HIGH motif; other site 420246003103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 420246003104 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 420246003105 active site 420246003106 KMSKS motif; other site 420246003107 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 420246003108 tRNA binding surface [nucleotide binding]; other site 420246003109 anticodon binding site; other site 420246003110 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 420246003111 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 420246003112 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 420246003113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246003114 RNA binding surface [nucleotide binding]; other site 420246003115 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 420246003116 active site 420246003117 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 420246003118 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246003119 active site 420246003120 uracil-xanthine permease; Region: ncs2; TIGR00801 420246003121 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 420246003122 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 420246003123 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 420246003124 dihydroorotase; Validated; Region: pyrC; PRK09357 420246003125 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 420246003126 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 420246003127 active site 420246003128 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 420246003129 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 420246003130 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 420246003131 catalytic site [active] 420246003132 subunit interface [polypeptide binding]; other site 420246003133 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 420246003134 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246003135 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 420246003136 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 420246003137 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246003138 ATP-grasp domain; Region: ATP-grasp_4; cl17255 420246003139 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 420246003140 IMP binding site; other site 420246003141 dimer interface [polypeptide binding]; other site 420246003142 interdomain contacts; other site 420246003143 partial ornithine binding site; other site 420246003144 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 420246003145 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 420246003146 FAD binding pocket [chemical binding]; other site 420246003147 FAD binding motif [chemical binding]; other site 420246003148 phosphate binding motif [ion binding]; other site 420246003149 beta-alpha-beta structure motif; other site 420246003150 NAD binding pocket [chemical binding]; other site 420246003151 Iron coordination center [ion binding]; other site 420246003152 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 420246003153 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 420246003154 heterodimer interface [polypeptide binding]; other site 420246003155 active site 420246003156 FMN binding site [chemical binding]; other site 420246003157 homodimer interface [polypeptide binding]; other site 420246003158 substrate binding site [chemical binding]; other site 420246003159 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 420246003160 active site 420246003161 dimer interface [polypeptide binding]; other site 420246003162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246003163 active site 420246003164 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 420246003165 Domain of unknown function (DUF814); Region: DUF814; pfam05670 420246003166 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 420246003167 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 420246003168 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 420246003169 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 420246003170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246003171 motif II; other site 420246003172 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 420246003173 hypothetical protein; Provisional; Region: PRK11820 420246003174 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 420246003175 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 420246003176 hypothetical protein; Provisional; Region: PRK04323 420246003177 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 420246003178 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 420246003179 catalytic site [active] 420246003180 G-X2-G-X-G-K; other site 420246003181 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 420246003182 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 420246003183 Flavoprotein; Region: Flavoprotein; pfam02441 420246003184 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 420246003185 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 420246003186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246003187 ATP binding site [chemical binding]; other site 420246003188 putative Mg++ binding site [ion binding]; other site 420246003189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246003190 nucleotide binding region [chemical binding]; other site 420246003191 ATP-binding site [chemical binding]; other site 420246003192 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 420246003193 active site 420246003194 catalytic residues [active] 420246003195 metal binding site [ion binding]; metal-binding site 420246003196 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 420246003197 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 420246003198 putative active site [active] 420246003199 substrate binding site [chemical binding]; other site 420246003200 putative cosubstrate binding site; other site 420246003201 catalytic site [active] 420246003202 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 420246003203 substrate binding site [chemical binding]; other site 420246003204 16S rRNA methyltransferase B; Provisional; Region: PRK14902 420246003205 NusB family; Region: NusB; pfam01029 420246003206 putative RNA binding site [nucleotide binding]; other site 420246003207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246003208 S-adenosylmethionine binding site [chemical binding]; other site 420246003209 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 420246003210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246003211 FeS/SAM binding site; other site 420246003212 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 420246003213 Protein phosphatase 2C; Region: PP2C; pfam00481 420246003214 active site 420246003215 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 420246003216 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 420246003217 active site 420246003218 ATP binding site [chemical binding]; other site 420246003219 substrate binding site [chemical binding]; other site 420246003220 activation loop (A-loop); other site 420246003221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 420246003222 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 420246003223 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 420246003224 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 420246003225 GTPase RsgA; Reviewed; Region: PRK00098 420246003226 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 420246003227 RNA binding site [nucleotide binding]; other site 420246003228 homodimer interface [polypeptide binding]; other site 420246003229 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 420246003230 GTPase/Zn-binding domain interface [polypeptide binding]; other site 420246003231 GTP/Mg2+ binding site [chemical binding]; other site 420246003232 G4 box; other site 420246003233 G5 box; other site 420246003234 G1 box; other site 420246003235 Switch I region; other site 420246003236 G2 box; other site 420246003237 G3 box; other site 420246003238 Switch II region; other site 420246003239 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 420246003240 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 420246003241 substrate binding site [chemical binding]; other site 420246003242 hexamer interface [polypeptide binding]; other site 420246003243 metal binding site [ion binding]; metal-binding site 420246003244 Thiamine pyrophosphokinase; Region: TPK; cd07995 420246003245 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 420246003246 active site 420246003247 dimerization interface [polypeptide binding]; other site 420246003248 thiamine binding site [chemical binding]; other site 420246003249 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 420246003250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 420246003251 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 420246003252 DAK2 domain; Region: Dak2; pfam02734 420246003253 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 420246003254 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 420246003255 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 420246003256 putative L-serine binding site [chemical binding]; other site 420246003257 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 420246003258 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 420246003259 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 420246003260 Y-family of DNA polymerases; Region: PolY; cl12025 420246003261 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 420246003262 generic binding surface II; other site 420246003263 ssDNA binding site; other site 420246003264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246003265 ATP binding site [chemical binding]; other site 420246003266 putative Mg++ binding site [ion binding]; other site 420246003267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246003268 nucleotide binding region [chemical binding]; other site 420246003269 ATP-binding site [chemical binding]; other site 420246003270 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 420246003271 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 420246003272 putative phosphate acyltransferase; Provisional; Region: PRK05331 420246003273 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 420246003274 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 420246003275 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 420246003276 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 420246003277 NAD(P) binding site [chemical binding]; other site 420246003278 homotetramer interface [polypeptide binding]; other site 420246003279 homodimer interface [polypeptide binding]; other site 420246003280 active site 420246003281 acyl carrier protein; Provisional; Region: acpP; PRK00982 420246003282 ribonuclease III; Reviewed; Region: rnc; PRK00102 420246003283 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 420246003284 dimerization interface [polypeptide binding]; other site 420246003285 active site 420246003286 metal binding site [ion binding]; metal-binding site 420246003287 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 420246003288 dsRNA binding site [nucleotide binding]; other site 420246003289 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 420246003290 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 420246003291 Walker A/P-loop; other site 420246003292 ATP binding site [chemical binding]; other site 420246003293 Q-loop/lid; other site 420246003294 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 420246003295 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 420246003296 ABC transporter signature motif; other site 420246003297 Walker B; other site 420246003298 D-loop; other site 420246003299 H-loop/switch region; other site 420246003300 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 420246003301 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 420246003302 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 420246003303 P loop; other site 420246003304 GTP binding site [chemical binding]; other site 420246003305 putative DNA-binding protein; Validated; Region: PRK00118 420246003306 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 420246003307 signal recognition particle protein; Provisional; Region: PRK10867 420246003308 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 420246003309 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 420246003310 P loop; other site 420246003311 GTP binding site [chemical binding]; other site 420246003312 Signal peptide binding domain; Region: SRP_SPB; pfam02978 420246003313 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 420246003314 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 420246003315 KH domain; Region: KH_4; pfam13083 420246003316 G-X-X-G motif; other site 420246003317 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 420246003318 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 420246003319 RimM N-terminal domain; Region: RimM; pfam01782 420246003320 PRC-barrel domain; Region: PRC; pfam05239 420246003321 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 420246003322 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 420246003323 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 420246003324 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 420246003325 Catalytic site [active] 420246003326 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 420246003327 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 420246003328 GTP/Mg2+ binding site [chemical binding]; other site 420246003329 G4 box; other site 420246003330 G5 box; other site 420246003331 G1 box; other site 420246003332 Switch I region; other site 420246003333 G2 box; other site 420246003334 G3 box; other site 420246003335 Switch II region; other site 420246003336 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 420246003337 RNA/DNA hybrid binding site [nucleotide binding]; other site 420246003338 active site 420246003339 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 420246003340 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 420246003341 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 420246003342 CoA-ligase; Region: Ligase_CoA; pfam00549 420246003343 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 420246003344 CoA binding domain; Region: CoA_binding; pfam02629 420246003345 CoA-ligase; Region: Ligase_CoA; pfam00549 420246003346 DNA protecting protein DprA; Region: dprA; TIGR00732 420246003347 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 420246003348 DNA topoisomerase I; Validated; Region: PRK05582 420246003349 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 420246003350 active site 420246003351 interdomain interaction site; other site 420246003352 putative metal-binding site [ion binding]; other site 420246003353 nucleotide binding site [chemical binding]; other site 420246003354 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 420246003355 domain I; other site 420246003356 DNA binding groove [nucleotide binding] 420246003357 phosphate binding site [ion binding]; other site 420246003358 domain II; other site 420246003359 domain III; other site 420246003360 nucleotide binding site [chemical binding]; other site 420246003361 catalytic site [active] 420246003362 domain IV; other site 420246003363 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 420246003364 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 420246003365 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 420246003366 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 420246003367 active site 420246003368 Int/Topo IB signature motif; other site 420246003369 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 420246003370 active site 420246003371 HslU subunit interaction site [polypeptide binding]; other site 420246003372 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 420246003373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246003374 Walker A motif; other site 420246003375 ATP binding site [chemical binding]; other site 420246003376 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 420246003377 Walker B motif; other site 420246003378 arginine finger; other site 420246003379 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 420246003380 transcriptional repressor CodY; Validated; Region: PRK04158 420246003381 CodY GAF-like domain; Region: CodY; pfam06018 420246003382 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 420246003383 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 420246003384 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 420246003385 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 420246003386 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 420246003387 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 420246003388 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 420246003389 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 420246003390 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 420246003391 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 420246003392 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 420246003393 MgtE intracellular N domain; Region: MgtE_N; cl15244 420246003394 FliG C-terminal domain; Region: FliG_C; pfam01706 420246003395 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 420246003396 Flagellar assembly protein FliH; Region: FliH; pfam02108 420246003397 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 420246003398 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 420246003399 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 420246003400 Walker A motif/ATP binding site; other site 420246003401 Walker B motif; other site 420246003402 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 420246003403 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 420246003404 MgtE intracellular N domain; Region: MgtE_N; pfam03448 420246003405 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 420246003406 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 420246003407 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 420246003408 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 420246003409 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 420246003410 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 420246003411 Flagellar protein (FlbD); Region: FlbD; pfam06289 420246003412 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 420246003413 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 420246003414 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 420246003415 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 420246003416 flagellar motor switch protein; Validated; Region: PRK08119 420246003417 CheC-like family; Region: CheC; pfam04509 420246003418 CheC-like family; Region: CheC; pfam04509 420246003419 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 420246003420 Response regulator receiver domain; Region: Response_reg; pfam00072 420246003421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246003422 active site 420246003423 phosphorylation site [posttranslational modification] 420246003424 intermolecular recognition site; other site 420246003425 dimerization interface [polypeptide binding]; other site 420246003426 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 420246003427 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 420246003428 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 420246003429 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 420246003430 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 420246003431 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 420246003432 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 420246003433 FHIPEP family; Region: FHIPEP; pfam00771 420246003434 septum-site determining protein; Validated; Region: minD; CHL00175 420246003435 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 420246003436 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 420246003437 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 420246003438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246003439 active site 420246003440 phosphorylation site [posttranslational modification] 420246003441 intermolecular recognition site; other site 420246003442 dimerization interface [polypeptide binding]; other site 420246003443 CheB methylesterase; Region: CheB_methylest; pfam01339 420246003444 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 420246003445 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 420246003446 putative binding surface; other site 420246003447 active site 420246003448 P2 response regulator binding domain; Region: P2; pfam07194 420246003449 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 420246003450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246003451 ATP binding site [chemical binding]; other site 420246003452 Mg2+ binding site [ion binding]; other site 420246003453 G-X-G motif; other site 420246003454 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 420246003455 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 420246003456 putative CheA interaction surface; other site 420246003457 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 420246003458 Chemotaxis phosphatase CheX; Region: CheX; cl15816 420246003459 CheC-like family; Region: CheC; pfam04509 420246003460 CheD chemotactic sensory transduction; Region: CheD; cl00810 420246003461 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 420246003462 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246003463 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 420246003464 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246003465 DNA binding residues [nucleotide binding] 420246003466 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 420246003467 rRNA interaction site [nucleotide binding]; other site 420246003468 S8 interaction site; other site 420246003469 putative laminin-1 binding site; other site 420246003470 elongation factor Ts; Provisional; Region: tsf; PRK09377 420246003471 UBA/TS-N domain; Region: UBA; pfam00627 420246003472 Elongation factor TS; Region: EF_TS; pfam00889 420246003473 Elongation factor TS; Region: EF_TS; pfam00889 420246003474 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 420246003475 putative nucleotide binding site [chemical binding]; other site 420246003476 uridine monophosphate binding site [chemical binding]; other site 420246003477 homohexameric interface [polypeptide binding]; other site 420246003478 ribosome recycling factor; Reviewed; Region: frr; PRK00083 420246003479 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 420246003480 hinge region; other site 420246003481 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 420246003482 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 420246003483 catalytic residue [active] 420246003484 putative FPP diphosphate binding site; other site 420246003485 putative FPP binding hydrophobic cleft; other site 420246003486 dimer interface [polypeptide binding]; other site 420246003487 putative IPP diphosphate binding site; other site 420246003488 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 420246003489 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 420246003490 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 420246003491 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 420246003492 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 420246003493 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 420246003494 RIP metalloprotease RseP; Region: TIGR00054 420246003495 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 420246003496 active site 420246003497 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 420246003498 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 420246003499 protein binding site [polypeptide binding]; other site 420246003500 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 420246003501 putative substrate binding region [chemical binding]; other site 420246003502 prolyl-tRNA synthetase; Provisional; Region: PRK09194 420246003503 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 420246003504 dimer interface [polypeptide binding]; other site 420246003505 motif 1; other site 420246003506 active site 420246003507 motif 2; other site 420246003508 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 420246003509 putative deacylase active site [active] 420246003510 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 420246003511 active site 420246003512 motif 3; other site 420246003513 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 420246003514 anticodon binding site; other site 420246003515 DNA polymerase III PolC; Validated; Region: polC; PRK00448 420246003516 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 420246003517 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 420246003518 generic binding surface I; other site 420246003519 generic binding surface II; other site 420246003520 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 420246003521 active site 420246003522 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 420246003523 active site 420246003524 catalytic site [active] 420246003525 substrate binding site [chemical binding]; other site 420246003526 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 420246003527 ribosome maturation protein RimP; Reviewed; Region: PRK00092 420246003528 Sm and related proteins; Region: Sm_like; cl00259 420246003529 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 420246003530 putative oligomer interface [polypeptide binding]; other site 420246003531 putative RNA binding site [nucleotide binding]; other site 420246003532 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 420246003533 NusA N-terminal domain; Region: NusA_N; pfam08529 420246003534 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 420246003535 RNA binding site [nucleotide binding]; other site 420246003536 homodimer interface [polypeptide binding]; other site 420246003537 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 420246003538 G-X-X-G motif; other site 420246003539 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 420246003540 G-X-X-G motif; other site 420246003541 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 420246003542 putative RNA binding cleft [nucleotide binding]; other site 420246003543 hypothetical protein; Provisional; Region: PRK07714 420246003544 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 420246003545 translation initiation factor IF-2; Region: IF-2; TIGR00487 420246003546 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 420246003547 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 420246003548 G1 box; other site 420246003549 putative GEF interaction site [polypeptide binding]; other site 420246003550 GTP/Mg2+ binding site [chemical binding]; other site 420246003551 Switch I region; other site 420246003552 G2 box; other site 420246003553 G3 box; other site 420246003554 Switch II region; other site 420246003555 G4 box; other site 420246003556 G5 box; other site 420246003557 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 420246003558 Translation-initiation factor 2; Region: IF-2; pfam11987 420246003559 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 420246003560 Protein of unknown function (DUF503); Region: DUF503; cl00669 420246003561 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 420246003562 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 420246003563 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 420246003564 RNA binding site [nucleotide binding]; other site 420246003565 active site 420246003566 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 420246003567 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 420246003568 active site 420246003569 Riboflavin kinase; Region: Flavokinase; pfam01687 420246003570 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 420246003571 16S/18S rRNA binding site [nucleotide binding]; other site 420246003572 S13e-L30e interaction site [polypeptide binding]; other site 420246003573 25S rRNA binding site [nucleotide binding]; other site 420246003574 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 420246003575 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 420246003576 RNase E interface [polypeptide binding]; other site 420246003577 trimer interface [polypeptide binding]; other site 420246003578 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 420246003579 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 420246003580 RNase E interface [polypeptide binding]; other site 420246003581 trimer interface [polypeptide binding]; other site 420246003582 active site 420246003583 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 420246003584 putative nucleic acid binding region [nucleotide binding]; other site 420246003585 G-X-X-G motif; other site 420246003586 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 420246003587 RNA binding site [nucleotide binding]; other site 420246003588 domain interface; other site 420246003589 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 420246003590 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 420246003591 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 420246003592 NodB motif; other site 420246003593 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 420246003594 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 420246003595 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 420246003596 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 420246003597 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 420246003598 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 420246003599 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 420246003600 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 420246003601 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 420246003602 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 420246003603 aspartate kinase I; Reviewed; Region: PRK08210 420246003604 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 420246003605 nucleotide binding site [chemical binding]; other site 420246003606 substrate binding site [chemical binding]; other site 420246003607 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 420246003608 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 420246003609 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 420246003610 dihydrodipicolinate synthase; Region: dapA; TIGR00674 420246003611 dimer interface [polypeptide binding]; other site 420246003612 active site 420246003613 catalytic residue [active] 420246003614 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 420246003615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246003616 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 420246003617 Clp protease; Region: CLP_protease; pfam00574 420246003618 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 420246003619 active site 420246003620 YlzJ-like protein; Region: YlzJ; pfam14035 420246003621 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 420246003622 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 420246003623 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 420246003624 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 420246003625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246003626 DNA-binding site [nucleotide binding]; DNA binding site 420246003627 UTRA domain; Region: UTRA; pfam07702 420246003628 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 420246003629 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 420246003630 ligand binding site [chemical binding]; other site 420246003631 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 420246003632 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 420246003633 Walker A/P-loop; other site 420246003634 ATP binding site [chemical binding]; other site 420246003635 Q-loop/lid; other site 420246003636 ABC transporter signature motif; other site 420246003637 Walker B; other site 420246003638 D-loop; other site 420246003639 H-loop/switch region; other site 420246003640 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 420246003641 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246003642 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 420246003643 TM-ABC transporter signature motif; other site 420246003644 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246003645 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 420246003646 TM-ABC transporter signature motif; other site 420246003647 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 420246003648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 420246003649 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 420246003650 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 420246003651 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 420246003652 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 420246003653 classical (c) SDRs; Region: SDR_c; cd05233 420246003654 NAD(P) binding site [chemical binding]; other site 420246003655 active site 420246003656 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 420246003657 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 420246003658 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 420246003659 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 420246003660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246003661 non-specific DNA binding site [nucleotide binding]; other site 420246003662 salt bridge; other site 420246003663 sequence-specific DNA binding site [nucleotide binding]; other site 420246003664 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 420246003665 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 420246003666 competence damage-inducible protein A; Provisional; Region: PRK00549 420246003667 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 420246003668 MPT binding site; other site 420246003669 Competence-damaged protein; Region: CinA; pfam02464 420246003670 recombinase A; Provisional; Region: recA; PRK09354 420246003671 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 420246003672 hexamer interface [polypeptide binding]; other site 420246003673 Walker A motif; other site 420246003674 ATP binding site [chemical binding]; other site 420246003675 Walker B motif; other site 420246003676 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 420246003677 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 420246003678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246003679 Zn2+ binding site [ion binding]; other site 420246003680 Mg2+ binding site [ion binding]; other site 420246003681 Cation efflux family; Region: Cation_efflux; cl00316 420246003682 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 420246003683 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 420246003684 putative active site [active] 420246003685 metal binding site [ion binding]; metal-binding site 420246003686 homodimer binding site [polypeptide binding]; other site 420246003687 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 420246003688 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 420246003689 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 420246003690 active site 420246003691 dimer interface [polypeptide binding]; other site 420246003692 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 420246003693 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 420246003694 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 420246003695 PYR/PP interface [polypeptide binding]; other site 420246003696 TPP binding site [chemical binding]; other site 420246003697 dimer interface [polypeptide binding]; other site 420246003698 substrate binding site [chemical binding]; other site 420246003699 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246003700 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 420246003701 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 420246003702 TPP-binding site [chemical binding]; other site 420246003703 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 420246003704 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 420246003705 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 420246003706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246003707 FeS/SAM binding site; other site 420246003708 TRAM domain; Region: TRAM; cl01282 420246003709 Predicted membrane protein [Function unknown]; Region: COG4550 420246003710 Outer spore coat protein E (CotE); Region: CotE; pfam10628 420246003711 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 420246003712 MutS domain I; Region: MutS_I; pfam01624 420246003713 MutS domain II; Region: MutS_II; pfam05188 420246003714 MutS domain III; Region: MutS_III; pfam05192 420246003715 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 420246003716 Walker A/P-loop; other site 420246003717 ATP binding site [chemical binding]; other site 420246003718 Q-loop/lid; other site 420246003719 ABC transporter signature motif; other site 420246003720 Walker B; other site 420246003721 D-loop; other site 420246003722 H-loop/switch region; other site 420246003723 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 420246003724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246003725 ATP binding site [chemical binding]; other site 420246003726 Mg2+ binding site [ion binding]; other site 420246003727 G-X-G motif; other site 420246003728 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 420246003729 ATP binding site [chemical binding]; other site 420246003730 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 420246003731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246003732 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 420246003733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246003734 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 420246003735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246003736 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 420246003737 NlpC/P60 family; Region: NLPC_P60; pfam00877 420246003738 BCCT family transporter; Region: BCCT; pfam02028 420246003739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246003740 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246003741 putative substrate translocation pore; other site 420246003742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 420246003743 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 420246003744 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 420246003745 bacterial Hfq-like; Region: Hfq; cd01716 420246003746 hexamer interface [polypeptide binding]; other site 420246003747 Sm1 motif; other site 420246003748 RNA binding site [nucleotide binding]; other site 420246003749 Sm2 motif; other site 420246003750 stage V sporulation protein K; Region: spore_V_K; TIGR02881 420246003751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246003752 Walker A motif; other site 420246003753 ATP binding site [chemical binding]; other site 420246003754 Walker B motif; other site 420246003755 arginine finger; other site 420246003756 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 420246003757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 420246003758 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 420246003759 acyl-activating enzyme (AAE) consensus motif; other site 420246003760 putative AMP binding site [chemical binding]; other site 420246003761 putative active site [active] 420246003762 putative CoA binding site [chemical binding]; other site 420246003763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246003764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 420246003765 active site 420246003766 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 420246003767 CoA-transferase family III; Region: CoA_transf_3; pfam02515 420246003768 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 420246003769 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 420246003770 dimer interface [polypeptide binding]; other site 420246003771 acyl-activating enzyme (AAE) consensus motif; other site 420246003772 putative active site [active] 420246003773 AMP binding site [chemical binding]; other site 420246003774 putative CoA binding site [chemical binding]; other site 420246003775 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 420246003776 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 420246003777 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 420246003778 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 420246003779 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 420246003780 dimer interface [polypeptide binding]; other site 420246003781 active site 420246003782 EamA-like transporter family; Region: EamA; pfam00892 420246003783 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 420246003784 EamA-like transporter family; Region: EamA; pfam00892 420246003785 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 420246003786 Predicted membrane protein [Function unknown]; Region: COG2860 420246003787 UPF0126 domain; Region: UPF0126; pfam03458 420246003788 UPF0126 domain; Region: UPF0126; pfam03458 420246003789 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 420246003790 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 420246003791 HflX GTPase family; Region: HflX; cd01878 420246003792 G1 box; other site 420246003793 GTP/Mg2+ binding site [chemical binding]; other site 420246003794 Switch I region; other site 420246003795 G2 box; other site 420246003796 G3 box; other site 420246003797 Switch II region; other site 420246003798 G4 box; other site 420246003799 G5 box; other site 420246003800 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 420246003801 Aluminium resistance protein; Region: Alum_res; pfam06838 420246003802 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 420246003803 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 420246003804 DNA binding residues [nucleotide binding] 420246003805 putative dimer interface [polypeptide binding]; other site 420246003806 glutamine synthetase, type I; Region: GlnA; TIGR00653 420246003807 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 420246003808 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 420246003809 LexA repressor; Validated; Region: PRK00215 420246003810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246003811 putative DNA binding site [nucleotide binding]; other site 420246003812 putative Zn2+ binding site [ion binding]; other site 420246003813 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 420246003814 Catalytic site [active] 420246003815 cell division suppressor protein YneA; Provisional; Region: PRK14125 420246003816 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246003817 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 420246003818 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 420246003819 catalytic residues [active] 420246003820 catalytic nucleophile [active] 420246003821 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 420246003822 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 420246003823 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 420246003824 TPP-binding site [chemical binding]; other site 420246003825 dimer interface [polypeptide binding]; other site 420246003826 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 420246003827 PYR/PP interface [polypeptide binding]; other site 420246003828 dimer interface [polypeptide binding]; other site 420246003829 TPP binding site [chemical binding]; other site 420246003830 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246003831 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 420246003832 hypothetical protein; Provisional; Region: PRK01844 420246003833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 420246003834 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 420246003835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246003836 Walker A/P-loop; other site 420246003837 ATP binding site [chemical binding]; other site 420246003838 Q-loop/lid; other site 420246003839 ABC transporter signature motif; other site 420246003840 Walker B; other site 420246003841 D-loop; other site 420246003842 H-loop/switch region; other site 420246003843 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 420246003844 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 420246003845 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 420246003846 Walker A/P-loop; other site 420246003847 ATP binding site [chemical binding]; other site 420246003848 Q-loop/lid; other site 420246003849 ABC transporter signature motif; other site 420246003850 Walker B; other site 420246003851 D-loop; other site 420246003852 H-loop/switch region; other site 420246003853 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 420246003854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246003855 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246003856 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 420246003857 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 420246003858 Response regulator receiver domain; Region: Response_reg; pfam00072 420246003859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246003860 active site 420246003861 phosphorylation site [posttranslational modification] 420246003862 intermolecular recognition site; other site 420246003863 dimerization interface [polypeptide binding]; other site 420246003864 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 420246003865 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 420246003866 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246003867 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 420246003868 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 420246003869 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 420246003870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246003871 Walker A motif; other site 420246003872 ATP binding site [chemical binding]; other site 420246003873 Walker B motif; other site 420246003874 arginine finger; other site 420246003875 Transcriptional antiterminator [Transcription]; Region: COG3933 420246003876 PRD domain; Region: PRD; pfam00874 420246003877 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 420246003878 active pocket/dimerization site; other site 420246003879 active site 420246003880 phosphorylation site [posttranslational modification] 420246003881 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 420246003882 active site 420246003883 P-loop; other site 420246003884 phosphorylation site [posttranslational modification] 420246003885 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 420246003886 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 420246003887 putative active site [active] 420246003888 YdjC motif; other site 420246003889 Mg binding site [ion binding]; other site 420246003890 putative homodimer interface [polypeptide binding]; other site 420246003891 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 420246003892 active site 420246003893 methionine cluster; other site 420246003894 phosphorylation site [posttranslational modification] 420246003895 metal binding site [ion binding]; metal-binding site 420246003896 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 420246003897 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 420246003898 aconitate hydratase; Validated; Region: PRK09277 420246003899 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 420246003900 substrate binding site [chemical binding]; other site 420246003901 ligand binding site [chemical binding]; other site 420246003902 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 420246003903 substrate binding site [chemical binding]; other site 420246003904 Divergent PAP2 family; Region: DUF212; pfam02681 420246003905 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 420246003906 EamA-like transporter family; Region: EamA; pfam00892 420246003907 hypothetical protein; Validated; Region: PRK07708 420246003908 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 420246003909 RNA/DNA hybrid binding site [nucleotide binding]; other site 420246003910 active site 420246003911 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 420246003912 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 420246003913 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 420246003914 DNA-binding site [nucleotide binding]; DNA binding site 420246003915 RNA-binding motif; other site 420246003916 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 420246003917 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 420246003918 amphipathic channel; other site 420246003919 Asn-Pro-Ala signature motifs; other site 420246003920 glycerol kinase; Provisional; Region: glpK; PRK00047 420246003921 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 420246003922 N- and C-terminal domain interface [polypeptide binding]; other site 420246003923 active site 420246003924 MgATP binding site [chemical binding]; other site 420246003925 catalytic site [active] 420246003926 metal binding site [ion binding]; metal-binding site 420246003927 glycerol binding site [chemical binding]; other site 420246003928 homotetramer interface [polypeptide binding]; other site 420246003929 homodimer interface [polypeptide binding]; other site 420246003930 FBP binding site [chemical binding]; other site 420246003931 protein IIAGlc interface [polypeptide binding]; other site 420246003932 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 420246003933 CoenzymeA binding site [chemical binding]; other site 420246003934 subunit interaction site [polypeptide binding]; other site 420246003935 PHB binding site; other site 420246003936 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 420246003937 CoenzymeA binding site [chemical binding]; other site 420246003938 subunit interaction site [polypeptide binding]; other site 420246003939 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 420246003940 PHB binding site; other site 420246003941 formimidoylglutamase; Provisional; Region: PRK13775 420246003942 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 420246003943 putative active site [active] 420246003944 putative metal binding site [ion binding]; other site 420246003945 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 420246003946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246003947 active site 420246003948 phosphorylation site [posttranslational modification] 420246003949 dimerization interface [polypeptide binding]; other site 420246003950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246003951 urocanate hydratase; Provisional; Region: PRK05414 420246003952 imidazolonepropionase; Validated; Region: PRK09356 420246003953 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 420246003954 active site 420246003955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 420246003956 Nucleoside recognition; Region: Gate; pfam07670 420246003957 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 420246003958 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 420246003959 Sulphur transport; Region: Sulf_transp; pfam04143 420246003960 Sulphur transport; Region: Sulf_transp; pfam04143 420246003961 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 420246003962 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 420246003963 substrate binding site [chemical binding]; other site 420246003964 ATP binding site [chemical binding]; other site 420246003965 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 420246003966 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 420246003967 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 420246003968 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 420246003969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 420246003970 Walker A motif; other site 420246003971 ATP binding site [chemical binding]; other site 420246003972 Walker B motif; other site 420246003973 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 420246003974 Predicted transcriptional regulator [Transcription]; Region: COG2345 420246003975 Predicted integral membrane protein [Function unknown]; Region: COG5505 420246003976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246003977 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246003978 Predicted transcriptional regulator [Transcription]; Region: COG2378 420246003979 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 420246003980 WYL domain; Region: WYL; pfam13280 420246003981 malate:quinone oxidoreductase; Validated; Region: PRK05257 420246003982 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 420246003983 hypothetical protein; Provisional; Region: PRK03057 420246003984 UPF0302 domain; Region: UPF0302; pfam08864 420246003985 A short protein domain of unknown function; Region: IDEAL; smart00914 420246003986 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 420246003987 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 420246003988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246003989 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 420246003990 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 420246003991 classical (c) SDRs; Region: SDR_c; cd05233 420246003992 NAD(P) binding site [chemical binding]; other site 420246003993 active site 420246003994 Wings apart-like protein regulation of heterochromatin; Region: WAPL; pfam07814 420246003995 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 420246003996 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 420246003997 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 420246003998 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 420246003999 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 420246004000 anti-sigma E factor; Provisional; Region: rseB; PRK09455 420246004001 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 420246004002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246004003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246004004 DNA binding residues [nucleotide binding] 420246004005 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 420246004006 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 420246004007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246004008 dimerization interface [polypeptide binding]; other site 420246004009 putative DNA binding site [nucleotide binding]; other site 420246004010 putative Zn2+ binding site [ion binding]; other site 420246004011 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 420246004012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 420246004013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 420246004014 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 420246004015 putative dimerization interface [polypeptide binding]; other site 420246004016 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 420246004017 Flavodoxin; Region: Flavodoxin_1; pfam00258 420246004018 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 420246004019 FAD binding pocket [chemical binding]; other site 420246004020 FAD binding motif [chemical binding]; other site 420246004021 catalytic residues [active] 420246004022 NAD binding pocket [chemical binding]; other site 420246004023 phosphate binding motif [ion binding]; other site 420246004024 beta-alpha-beta structure motif; other site 420246004025 sulfite reductase subunit beta; Provisional; Region: PRK13504 420246004026 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 420246004027 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 420246004028 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 420246004029 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246004030 NAD(P) binding site [chemical binding]; other site 420246004031 catalytic residues [active] 420246004032 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 420246004033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246004034 ABC-ATPase subunit interface; other site 420246004035 dimer interface [polypeptide binding]; other site 420246004036 putative PBP binding regions; other site 420246004037 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246004038 ABC-ATPase subunit interface; other site 420246004039 dimer interface [polypeptide binding]; other site 420246004040 putative PBP binding regions; other site 420246004041 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 420246004042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 420246004043 Walker A/P-loop; other site 420246004044 ATP binding site [chemical binding]; other site 420246004045 Q-loop/lid; other site 420246004046 ABC transporter signature motif; other site 420246004047 Walker B; other site 420246004048 D-loop; other site 420246004049 H-loop/switch region; other site 420246004050 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 420246004051 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 420246004052 putative ligand binding residues [chemical binding]; other site 420246004053 AAA domain; Region: AAA_30; pfam13604 420246004054 AAA domain; Region: AAA_11; pfam13086 420246004055 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 420246004056 AAA domain; Region: AAA_12; pfam13087 420246004057 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 420246004058 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 420246004059 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 420246004060 ligand binding site [chemical binding]; other site 420246004061 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 420246004062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246004063 ATP binding site [chemical binding]; other site 420246004064 putative Mg++ binding site [ion binding]; other site 420246004065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246004066 nucleotide binding region [chemical binding]; other site 420246004067 ATP-binding site [chemical binding]; other site 420246004068 DNA methylase; Region: N6_N4_Mtase; cl17433 420246004069 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 420246004070 DNA methylase; Region: N6_N4_Mtase; pfam01555 420246004071 DNA methylase; Region: N6_N4_Mtase; cl17433 420246004072 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 420246004073 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 420246004074 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 420246004075 aminotransferase; Validated; Region: PRK07678 420246004076 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 420246004077 inhibitor-cofactor binding pocket; inhibition site 420246004078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246004079 catalytic residue [active] 420246004080 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 420246004081 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 420246004082 putative NADP binding site [chemical binding]; other site 420246004083 putative dimer interface [polypeptide binding]; other site 420246004084 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 420246004085 Beta-lactamase; Region: Beta-lactamase; pfam00144 420246004086 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 420246004087 Bacterial Ig-like domain 2; Region: BID_2; smart00635 420246004088 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 420246004089 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 420246004090 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 420246004091 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 420246004092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 420246004093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 420246004094 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 420246004095 putative dimerization interface [polypeptide binding]; other site 420246004096 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 420246004097 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 420246004098 active site 420246004099 dimer interface [polypeptide binding]; other site 420246004100 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 420246004101 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 420246004102 active site 420246004103 FMN binding site [chemical binding]; other site 420246004104 substrate binding site [chemical binding]; other site 420246004105 3Fe-4S cluster binding site [ion binding]; other site 420246004106 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 420246004107 domain interface; other site 420246004108 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 420246004109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 420246004110 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246004111 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 420246004112 active site 420246004113 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 420246004114 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 420246004115 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 420246004116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 420246004117 Phosphotransferase enzyme family; Region: APH; pfam01636 420246004118 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 420246004119 active site 420246004120 ATP binding site [chemical binding]; other site 420246004121 NAD-dependent deacetylase; Provisional; Region: PRK00481 420246004122 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 420246004123 NAD+ binding site [chemical binding]; other site 420246004124 substrate binding site [chemical binding]; other site 420246004125 Zn binding site [ion binding]; other site 420246004126 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 420246004127 intracellular protease, PfpI family; Region: PfpI; TIGR01382 420246004128 conserved cys residue [active] 420246004129 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 420246004130 EamA-like transporter family; Region: EamA; pfam00892 420246004131 EamA-like transporter family; Region: EamA; pfam00892 420246004132 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 420246004133 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 420246004134 Malic enzyme, N-terminal domain; Region: malic; pfam00390 420246004135 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 420246004136 putative NAD(P) binding site [chemical binding]; other site 420246004137 hypothetical protein; Provisional; Region: PRK02947 420246004138 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 420246004139 putative active site [active] 420246004140 uridine kinase; Provisional; Region: PRK07667 420246004141 active site 420246004142 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 420246004143 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 420246004144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246004146 putative substrate translocation pore; other site 420246004147 Predicted membrane protein [Function unknown]; Region: COG4640 420246004148 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 420246004149 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 420246004150 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 420246004151 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 420246004152 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 420246004153 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 420246004154 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 420246004155 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 420246004156 metal binding triad; other site 420246004157 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 420246004158 hypothetical protein; Provisional; Region: PRK07740 420246004159 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 420246004160 active site 420246004161 catalytic site [active] 420246004162 substrate binding site [chemical binding]; other site 420246004163 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 420246004164 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 420246004165 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 420246004166 siderophore binding site; other site 420246004167 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 420246004168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246004169 ABC-ATPase subunit interface; other site 420246004170 dimer interface [polypeptide binding]; other site 420246004171 putative PBP binding regions; other site 420246004172 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 420246004173 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246004174 ABC-ATPase subunit interface; other site 420246004175 dimer interface [polypeptide binding]; other site 420246004176 putative PBP binding regions; other site 420246004177 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 420246004178 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 420246004179 Walker A/P-loop; other site 420246004180 ATP binding site [chemical binding]; other site 420246004181 Q-loop/lid; other site 420246004182 ABC transporter signature motif; other site 420246004183 Walker B; other site 420246004184 D-loop; other site 420246004185 H-loop/switch region; other site 420246004186 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 420246004187 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 420246004188 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 420246004189 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 420246004190 nudix motif; other site 420246004191 putative acetyltransferase; Provisional; Region: PRK03624 420246004192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246004194 Coenzyme A binding pocket [chemical binding]; other site 420246004195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 420246004196 catalytic core [active] 420246004197 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 420246004198 Nucleoside recognition; Region: Gate; pfam07670 420246004199 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 420246004200 Nucleoside recognition; Region: Gate; pfam07670 420246004201 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 420246004202 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 420246004203 G1 box; other site 420246004204 GTP/Mg2+ binding site [chemical binding]; other site 420246004205 Switch I region; other site 420246004206 G2 box; other site 420246004207 G3 box; other site 420246004208 Switch II region; other site 420246004209 G4 box; other site 420246004210 G5 box; other site 420246004211 FeoA domain; Region: FeoA; pfam04023 420246004212 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 420246004213 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 420246004214 acyl-activating enzyme (AAE) consensus motif; other site 420246004215 putative AMP binding site [chemical binding]; other site 420246004216 putative active site [active] 420246004217 putative CoA binding site [chemical binding]; other site 420246004218 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 420246004219 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 420246004220 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 420246004221 Walker A/P-loop; other site 420246004222 ATP binding site [chemical binding]; other site 420246004223 Q-loop/lid; other site 420246004224 ABC transporter signature motif; other site 420246004225 Walker B; other site 420246004226 D-loop; other site 420246004227 H-loop/switch region; other site 420246004228 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 420246004229 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 420246004230 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 420246004231 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 420246004232 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 420246004233 DNA binding residues [nucleotide binding] 420246004234 putative dimer interface [polypeptide binding]; other site 420246004235 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 420246004236 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 420246004237 acyl-activating enzyme (AAE) consensus motif; other site 420246004238 putative AMP binding site [chemical binding]; other site 420246004239 putative active site [active] 420246004240 putative CoA binding site [chemical binding]; other site 420246004241 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 420246004242 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246004243 active site 420246004244 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 420246004245 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 420246004246 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 420246004247 TrkA-N domain; Region: TrkA_N; pfam02254 420246004248 TrkA-C domain; Region: TrkA_C; pfam02080 420246004249 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 420246004250 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 420246004251 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 420246004252 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 420246004253 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 420246004254 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 420246004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246004257 putative substrate translocation pore; other site 420246004258 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 420246004259 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 420246004260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246004261 dimer interface [polypeptide binding]; other site 420246004262 conserved gate region; other site 420246004263 ABC-ATPase subunit interface; other site 420246004264 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 420246004265 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 420246004266 Walker A/P-loop; other site 420246004267 ATP binding site [chemical binding]; other site 420246004268 Q-loop/lid; other site 420246004269 ABC transporter signature motif; other site 420246004270 Walker B; other site 420246004271 D-loop; other site 420246004272 H-loop/switch region; other site 420246004273 NIL domain; Region: NIL; pfam09383 420246004274 putative carbohydrate kinase; Provisional; Region: PRK10565 420246004275 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 420246004276 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 420246004277 putative substrate binding site [chemical binding]; other site 420246004278 putative ATP binding site [chemical binding]; other site 420246004279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004280 Coenzyme A binding pocket [chemical binding]; other site 420246004281 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 420246004282 Transcriptional regulator [Transcription]; Region: IclR; COG1414 420246004283 Bacterial transcriptional regulator; Region: IclR; pfam01614 420246004284 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 420246004285 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 420246004286 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 420246004287 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 420246004288 putative active site [active] 420246004289 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 420246004290 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 420246004291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246004292 motif II; other site 420246004293 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 420246004294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 420246004295 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 420246004296 acyl-activating enzyme (AAE) consensus motif; other site 420246004297 putative AMP binding site [chemical binding]; other site 420246004298 putative active site [active] 420246004299 putative CoA binding site [chemical binding]; other site 420246004300 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 420246004301 active site 420246004302 substrate binding pocket [chemical binding]; other site 420246004303 homodimer interaction site [polypeptide binding]; other site 420246004304 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 420246004305 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 420246004306 Ligand binding site; other site 420246004307 Putative Catalytic site; other site 420246004308 DXD motif; other site 420246004309 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 420246004310 substrate binding site [chemical binding]; other site 420246004311 multimerization interface [polypeptide binding]; other site 420246004312 ATP binding site [chemical binding]; other site 420246004313 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 420246004314 dimer interface [polypeptide binding]; other site 420246004315 substrate binding site [chemical binding]; other site 420246004316 ATP binding site [chemical binding]; other site 420246004317 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 420246004318 thiamine phosphate binding site [chemical binding]; other site 420246004319 active site 420246004320 pyrophosphate binding site [ion binding]; other site 420246004321 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 420246004322 Small acid-soluble spore protein H family; Region: SspH; pfam08141 420246004323 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 420246004324 Uncharacterized conserved protein [Function unknown]; Region: COG1284 420246004325 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246004326 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 420246004327 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 420246004328 active site 420246004329 catalytic triad [active] 420246004330 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 420246004331 Histidine kinase N terminal; Region: HisK_N; pfam09385 420246004332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246004333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246004334 dimer interface [polypeptide binding]; other site 420246004335 phosphorylation site [posttranslational modification] 420246004336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246004337 ATP binding site [chemical binding]; other site 420246004338 Mg2+ binding site [ion binding]; other site 420246004339 G-X-G motif; other site 420246004340 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 420246004341 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 420246004342 dimer interface [polypeptide binding]; other site 420246004343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246004344 catalytic residue [active] 420246004345 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 420246004346 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 420246004347 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 420246004348 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 420246004349 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 420246004350 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 420246004351 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 420246004352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 420246004353 Walker A/P-loop; other site 420246004354 ATP binding site [chemical binding]; other site 420246004355 Q-loop/lid; other site 420246004356 ABC transporter signature motif; other site 420246004357 Walker B; other site 420246004358 D-loop; other site 420246004359 H-loop/switch region; other site 420246004360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246004361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246004362 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 420246004363 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 420246004364 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 420246004365 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 420246004366 FAD binding domain; Region: FAD_binding_4; pfam01565 420246004367 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 420246004368 Cysteine-rich domain; Region: CCG; pfam02754 420246004369 Cysteine-rich domain; Region: CCG; pfam02754 420246004370 FAD binding domain; Region: FAD_binding_4; pfam01565 420246004371 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 420246004372 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 420246004373 active site 420246004374 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 420246004375 Malic enzyme, N-terminal domain; Region: malic; pfam00390 420246004376 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 420246004377 putative NAD(P) binding site [chemical binding]; other site 420246004378 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 420246004379 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 420246004380 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 420246004381 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 420246004382 Transcriptional regulator [Transcription]; Region: IclR; COG1414 420246004383 Bacterial transcriptional regulator; Region: IclR; pfam01614 420246004384 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 420246004385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246004386 ATP binding site [chemical binding]; other site 420246004387 putative Mg++ binding site [ion binding]; other site 420246004388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246004389 nucleotide binding region [chemical binding]; other site 420246004390 ATP-binding site [chemical binding]; other site 420246004391 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 420246004392 RNase_H superfamily; Region: RNase_H_2; pfam13482 420246004393 active site 420246004394 substrate binding site [chemical binding]; other site 420246004395 cell division protein GpsB; Provisional; Region: PRK14127 420246004396 DivIVA domain; Region: DivI1A_domain; TIGR03544 420246004397 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 420246004398 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 420246004399 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 420246004400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246004401 S-adenosylmethionine binding site [chemical binding]; other site 420246004402 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 420246004403 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 420246004404 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 420246004405 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 420246004406 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 420246004407 active site 420246004408 Zn binding site [ion binding]; other site 420246004409 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 420246004410 Putative D-pathway homolog; other site 420246004411 Low-spin heme binding site [chemical binding]; other site 420246004412 Subunit I/II interface [polypeptide binding]; other site 420246004413 Putative Q-pathway; other site 420246004414 Putative alternate electron transfer pathway; other site 420246004415 Putative water exit pathway; other site 420246004416 Binuclear center (active site) [active] 420246004417 Putative K-pathway homolog; other site 420246004418 Putative proton exit pathway; other site 420246004419 Subunit I/IIa interface [polypeptide binding]; other site 420246004420 Electron transfer pathway; other site 420246004421 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 420246004422 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 420246004423 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246004424 active site 420246004425 xanthine permease; Region: pbuX; TIGR03173 420246004426 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 420246004427 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 420246004428 Walker A/P-loop; other site 420246004429 ATP binding site [chemical binding]; other site 420246004430 Q-loop/lid; other site 420246004431 ABC transporter signature motif; other site 420246004432 Walker B; other site 420246004433 D-loop; other site 420246004434 H-loop/switch region; other site 420246004435 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 420246004436 FtsX-like permease family; Region: FtsX; pfam02687 420246004437 Predicted transcriptional regulators [Transcription]; Region: COG1695 420246004438 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 420246004439 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 420246004440 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 420246004441 malonyl-CoA binding site [chemical binding]; other site 420246004442 dimer interface [polypeptide binding]; other site 420246004443 active site 420246004444 product binding site; other site 420246004445 Phospholipid methyltransferase; Region: PEMT; cl17370 420246004446 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 420246004447 Dynamin family; Region: Dynamin_N; pfam00350 420246004448 G1 box; other site 420246004449 GTP/Mg2+ binding site [chemical binding]; other site 420246004450 G2 box; other site 420246004451 Switch I region; other site 420246004452 G3 box; other site 420246004453 Switch II region; other site 420246004454 G4 box; other site 420246004455 G5 box; other site 420246004456 Dynamin family; Region: Dynamin_N; pfam00350 420246004457 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 420246004458 G3 box; other site 420246004459 Switch II region; other site 420246004460 GTP/Mg2+ binding site [chemical binding]; other site 420246004461 G4 box; other site 420246004462 G5 box; other site 420246004463 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 420246004464 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 420246004465 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 420246004466 active site residue [active] 420246004467 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 420246004468 active site residue [active] 420246004469 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 420246004470 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 420246004471 catalytic residues [active] 420246004472 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 420246004473 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 420246004474 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 420246004475 active site 420246004476 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 420246004477 CoenzymeA binding site [chemical binding]; other site 420246004478 subunit interaction site [polypeptide binding]; other site 420246004479 PHB binding site; other site 420246004480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 420246004481 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 420246004482 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 420246004483 Cl binding site [ion binding]; other site 420246004484 oligomer interface [polypeptide binding]; other site 420246004485 Protein of unknown function (DUF502); Region: DUF502; cl01107 420246004486 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 420246004487 biotin synthase; Validated; Region: PRK06256 420246004488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246004489 FeS/SAM binding site; other site 420246004490 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 420246004491 hypothetical protein; Provisional; Region: PRK13672 420246004492 YozD-like protein; Region: YozD; pfam14162 420246004493 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 420246004494 YodL-like; Region: YodL; pfam14191 420246004495 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 420246004496 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 420246004497 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 420246004498 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 420246004499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246004500 S-adenosylmethionine binding site [chemical binding]; other site 420246004501 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 420246004502 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 420246004503 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 420246004504 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 420246004505 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 420246004506 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 420246004507 oligomer interface [polypeptide binding]; other site 420246004508 Predicted permeases [General function prediction only]; Region: RarD; COG2962 420246004509 EamA-like transporter family; Region: EamA; pfam00892 420246004510 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 420246004511 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 420246004512 multidrug efflux protein; Reviewed; Region: PRK01766 420246004513 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 420246004514 cation binding site [ion binding]; other site 420246004515 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 420246004516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246004517 putative active site [active] 420246004518 heme pocket [chemical binding]; other site 420246004519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246004520 phosphorylation site [posttranslational modification] 420246004521 dimer interface [polypeptide binding]; other site 420246004522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246004523 ATP binding site [chemical binding]; other site 420246004524 Mg2+ binding site [ion binding]; other site 420246004525 G-X-G motif; other site 420246004526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246004528 putative substrate translocation pore; other site 420246004529 threonine dehydratase; Provisional; Region: PRK08198 420246004530 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 420246004531 tetramer interface [polypeptide binding]; other site 420246004532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246004533 catalytic residue [active] 420246004534 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 420246004535 Predicted acetyltransferase [General function prediction only]; Region: COG3393 420246004536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246004538 Coenzyme A binding pocket [chemical binding]; other site 420246004539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246004540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246004541 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 420246004542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246004543 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 420246004544 FAD binding site [chemical binding]; other site 420246004545 homotetramer interface [polypeptide binding]; other site 420246004546 substrate binding pocket [chemical binding]; other site 420246004547 catalytic base [active] 420246004548 AMP-binding domain protein; Validated; Region: PRK08315 420246004549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 420246004550 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 420246004551 acyl-activating enzyme (AAE) consensus motif; other site 420246004552 acyl-activating enzyme (AAE) consensus motif; other site 420246004553 putative AMP binding site [chemical binding]; other site 420246004554 putative active site [active] 420246004555 putative CoA binding site [chemical binding]; other site 420246004556 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 420246004557 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246004558 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 420246004559 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 420246004560 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 420246004561 carboxyltransferase (CT) interaction site; other site 420246004562 biotinylation site [posttranslational modification]; other site 420246004563 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 420246004564 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 420246004565 active site 420246004566 catalytic residues [active] 420246004567 metal binding site [ion binding]; metal-binding site 420246004568 enoyl-CoA hydratase; Provisional; Region: PRK07657 420246004569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246004570 substrate binding site [chemical binding]; other site 420246004571 oxyanion hole (OAH) forming residues; other site 420246004572 trimer interface [polypeptide binding]; other site 420246004573 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 420246004574 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 420246004575 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 420246004576 MarR family; Region: MarR; pfam01047 420246004577 HlyD family secretion protein; Region: HlyD_3; pfam13437 420246004578 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 420246004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004580 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 420246004581 putative substrate translocation pore; other site 420246004582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004583 NETI protein; Region: NETI; pfam14044 420246004584 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 420246004585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246004586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246004587 dimer interface [polypeptide binding]; other site 420246004588 phosphorylation site [posttranslational modification] 420246004589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246004590 ATP binding site [chemical binding]; other site 420246004591 Mg2+ binding site [ion binding]; other site 420246004592 G-X-G motif; other site 420246004593 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 420246004594 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 420246004595 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 420246004596 Spore germination protein; Region: Spore_permease; cl17796 420246004597 Predicted transcriptional regulators [Transcription]; Region: COG1725 420246004598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246004599 DNA-binding site [nucleotide binding]; DNA binding site 420246004600 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 420246004601 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 420246004602 Walker A/P-loop; other site 420246004603 ATP binding site [chemical binding]; other site 420246004604 Q-loop/lid; other site 420246004605 ABC transporter signature motif; other site 420246004606 Walker B; other site 420246004607 D-loop; other site 420246004608 H-loop/switch region; other site 420246004609 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 420246004610 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 420246004611 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 420246004612 Spore germination protein; Region: Spore_permease; pfam03845 420246004613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246004614 PAS domain; Region: PAS_9; pfam13426 420246004615 putative active site [active] 420246004616 heme pocket [chemical binding]; other site 420246004617 PAS domain; Region: PAS_9; pfam13426 420246004618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 420246004619 putative active site [active] 420246004620 heme pocket [chemical binding]; other site 420246004621 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 420246004622 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 420246004623 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 420246004624 anti sigma factor interaction site; other site 420246004625 regulatory phosphorylation site [posttranslational modification]; other site 420246004626 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 420246004627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 420246004628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246004629 Walker A/P-loop; other site 420246004630 ATP binding site [chemical binding]; other site 420246004631 Q-loop/lid; other site 420246004632 ABC transporter signature motif; other site 420246004633 Walker B; other site 420246004634 D-loop; other site 420246004635 H-loop/switch region; other site 420246004636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 420246004637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 420246004638 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 420246004639 Walker A/P-loop; other site 420246004640 ATP binding site [chemical binding]; other site 420246004641 Q-loop/lid; other site 420246004642 ABC transporter signature motif; other site 420246004643 Walker B; other site 420246004644 D-loop; other site 420246004645 H-loop/switch region; other site 420246004646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 420246004647 MOSC domain; Region: MOSC; pfam03473 420246004648 3-alpha domain; Region: 3-alpha; pfam03475 420246004649 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 420246004650 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 420246004651 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 420246004652 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 420246004653 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 420246004654 putative catalytic residue [active] 420246004655 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 420246004656 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 420246004657 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 420246004658 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 420246004659 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 420246004660 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 420246004661 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 420246004662 substrate binding site [chemical binding]; other site 420246004663 ATP binding site [chemical binding]; other site 420246004664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004665 D-galactonate transporter; Region: 2A0114; TIGR00893 420246004666 putative substrate translocation pore; other site 420246004667 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 420246004668 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 420246004669 active site 420246004670 intersubunit interface [polypeptide binding]; other site 420246004671 catalytic residue [active] 420246004672 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246004673 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246004674 DNA binding site [nucleotide binding] 420246004675 domain linker motif; other site 420246004676 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 420246004677 putative dimerization interface [polypeptide binding]; other site 420246004678 putative ligand binding site [chemical binding]; other site 420246004679 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 420246004680 active site 420246004681 dimer interface [polypeptide binding]; other site 420246004682 magnesium binding site [ion binding]; other site 420246004683 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 420246004684 tetramer interface [polypeptide binding]; other site 420246004685 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 420246004686 active site 420246004687 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 420246004688 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246004689 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 420246004690 active site 420246004691 catalytic triad [active] 420246004692 oxyanion hole [active] 420246004693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 420246004694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246004695 Walker A/P-loop; other site 420246004696 ATP binding site [chemical binding]; other site 420246004697 Q-loop/lid; other site 420246004698 ABC transporter signature motif; other site 420246004699 Walker B; other site 420246004700 D-loop; other site 420246004701 H-loop/switch region; other site 420246004702 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 420246004703 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 420246004704 Pirin-related protein [General function prediction only]; Region: COG1741 420246004705 Pirin; Region: Pirin; pfam02678 420246004706 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 420246004707 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 420246004708 dimer interface [polypeptide binding]; other site 420246004709 FMN binding site [chemical binding]; other site 420246004710 NADPH bind site [chemical binding]; other site 420246004711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246004712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246004713 putative substrate translocation pore; other site 420246004714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246004715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246004716 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 420246004717 NAD-dependent deacetylase; Provisional; Region: PRK00481 420246004718 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 420246004719 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246004720 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 420246004721 active site 420246004722 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 420246004723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246004724 NAD(P) binding site [chemical binding]; other site 420246004725 active site 420246004726 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 420246004727 active site 420246004728 catalytic site [active] 420246004729 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 420246004730 active site 420246004731 catalytic site [active] 420246004732 putative acyltransferase; Provisional; Region: PRK05790 420246004733 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 420246004734 dimer interface [polypeptide binding]; other site 420246004735 active site 420246004736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246004737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246004738 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 420246004739 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246004740 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 420246004741 TM-ABC transporter signature motif; other site 420246004742 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246004743 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 420246004744 TM-ABC transporter signature motif; other site 420246004745 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 420246004746 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 420246004747 Walker A/P-loop; other site 420246004748 ATP binding site [chemical binding]; other site 420246004749 Q-loop/lid; other site 420246004750 ABC transporter signature motif; other site 420246004751 Walker B; other site 420246004752 D-loop; other site 420246004753 H-loop/switch region; other site 420246004754 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 420246004755 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 420246004756 Walker A/P-loop; other site 420246004757 ATP binding site [chemical binding]; other site 420246004758 Q-loop/lid; other site 420246004759 ABC transporter signature motif; other site 420246004760 Walker B; other site 420246004761 D-loop; other site 420246004762 H-loop/switch region; other site 420246004763 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 420246004764 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 420246004765 putative ligand binding site [chemical binding]; other site 420246004766 QueT transporter; Region: QueT; pfam06177 420246004767 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 420246004768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 420246004769 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 420246004770 Low-spin heme binding site [chemical binding]; other site 420246004771 D-pathway; other site 420246004772 Putative water exit pathway; other site 420246004773 Binuclear center (active site) [active] 420246004774 K-pathway; other site 420246004775 Putative proton exit pathway; other site 420246004776 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 420246004777 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 420246004778 Cu(I) binding site [ion binding]; other site 420246004779 Protein of unknown function, DUF606; Region: DUF606; pfam04657 420246004780 Predicted membrane protein [Function unknown]; Region: COG1511 420246004781 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 420246004782 Predicted membrane protein [Function unknown]; Region: COG1511 420246004783 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 420246004784 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 420246004785 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 420246004786 Walker A/P-loop; other site 420246004787 ATP binding site [chemical binding]; other site 420246004788 Q-loop/lid; other site 420246004789 ABC transporter signature motif; other site 420246004790 Walker B; other site 420246004791 D-loop; other site 420246004792 H-loop/switch region; other site 420246004793 short chain dehydrogenase; Provisional; Region: PRK06172 420246004794 classical (c) SDRs; Region: SDR_c; cd05233 420246004795 NAD(P) binding site [chemical binding]; other site 420246004796 active site 420246004797 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 420246004798 classical (c) SDRs; Region: SDR_c; cd05233 420246004799 NAD(P) binding site [chemical binding]; other site 420246004800 active site 420246004801 enoyl-CoA hydratase; Provisional; Region: PRK06688 420246004802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246004803 substrate binding site [chemical binding]; other site 420246004804 oxyanion hole (OAH) forming residues; other site 420246004805 trimer interface [polypeptide binding]; other site 420246004806 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 420246004807 Catalytic domain of Protein Kinases; Region: PKc; cd00180 420246004808 active site 420246004809 ATP binding site [chemical binding]; other site 420246004810 substrate binding site [chemical binding]; other site 420246004811 activation loop (A-loop); other site 420246004812 DNA topoisomerase III; Provisional; Region: PRK07726 420246004813 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 420246004814 active site 420246004815 putative interdomain interaction site [polypeptide binding]; other site 420246004816 putative metal-binding site [ion binding]; other site 420246004817 putative nucleotide binding site [chemical binding]; other site 420246004818 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 420246004819 domain I; other site 420246004820 DNA binding groove [nucleotide binding] 420246004821 phosphate binding site [ion binding]; other site 420246004822 domain II; other site 420246004823 domain III; other site 420246004824 nucleotide binding site [chemical binding]; other site 420246004825 catalytic site [active] 420246004826 domain IV; other site 420246004827 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 420246004828 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 420246004829 putative homodimer interface [polypeptide binding]; other site 420246004830 putative homotetramer interface [polypeptide binding]; other site 420246004831 allosteric switch controlling residues; other site 420246004832 putative metal binding site [ion binding]; other site 420246004833 putative homodimer-homodimer interface [polypeptide binding]; other site 420246004834 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 420246004835 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 420246004836 metal-binding site [ion binding] 420246004837 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 420246004838 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 420246004839 metal-binding site [ion binding] 420246004840 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 420246004841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246004842 motif II; other site 420246004843 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 420246004844 metal-binding site [ion binding] 420246004845 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 420246004846 Uncharacterized conserved protein [Function unknown]; Region: COG3402 420246004847 Predicted membrane protein [Function unknown]; Region: COG3428 420246004848 Bacterial PH domain; Region: DUF304; pfam03703 420246004849 Bacterial PH domain; Region: DUF304; pfam03703 420246004850 Bacterial PH domain; Region: DUF304; pfam03703 420246004851 Lysine efflux permease [General function prediction only]; Region: COG1279 420246004852 DNA polymerase IV; Validated; Region: PRK01810 420246004853 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 420246004854 active site 420246004855 DNA binding site [nucleotide binding] 420246004856 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 420246004857 arsenical pump membrane protein; Provisional; Region: PRK15445 420246004858 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 420246004859 transmembrane helices; other site 420246004860 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 420246004861 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 420246004862 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 420246004863 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 420246004864 Protein of unknown function (DUF342); Region: DUF342; pfam03961 420246004865 Transposase, Mutator family; Region: Transposase_mut; pfam00872 420246004866 MULE transposase domain; Region: MULE; pfam10551 420246004867 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 420246004868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246004869 active site 420246004870 phosphorylation site [posttranslational modification] 420246004871 intermolecular recognition site; other site 420246004872 dimerization interface [polypeptide binding]; other site 420246004873 LytTr DNA-binding domain; Region: LytTR; smart00850 420246004874 PAS fold; Region: PAS_4; pfam08448 420246004875 PAS domain S-box; Region: sensory_box; TIGR00229 420246004876 PAS domain; Region: PAS; smart00091 420246004877 putative active site [active] 420246004878 heme pocket [chemical binding]; other site 420246004879 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246004880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246004881 metal binding site [ion binding]; metal-binding site 420246004882 active site 420246004883 I-site; other site 420246004884 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 420246004885 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 420246004886 dimer interface [polypeptide binding]; other site 420246004887 active site 420246004888 heme binding site [chemical binding]; other site 420246004889 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 420246004890 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 420246004891 nudix motif; other site 420246004892 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 420246004893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246004894 putative DNA binding site [nucleotide binding]; other site 420246004895 putative Zn2+ binding site [ion binding]; other site 420246004896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 420246004897 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 420246004898 ABC transporter; Region: ABC_tran_2; pfam12848 420246004899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 420246004900 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 420246004901 Methyltransferase domain; Region: Methyltransf_31; pfam13847 420246004902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246004903 S-adenosylmethionine binding site [chemical binding]; other site 420246004904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 420246004905 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 420246004906 FtsI repressor; Provisional; Region: PRK10883 420246004907 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 420246004908 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 420246004909 Predicted amidohydrolase [General function prediction only]; Region: COG0388 420246004910 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 420246004911 active site 420246004912 catalytic triad [active] 420246004913 dimer interface [polypeptide binding]; other site 420246004914 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 420246004915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246004916 S-adenosylmethionine binding site [chemical binding]; other site 420246004917 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 420246004918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246004919 non-specific DNA binding site [nucleotide binding]; other site 420246004920 salt bridge; other site 420246004921 sequence-specific DNA binding site [nucleotide binding]; other site 420246004922 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 420246004923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004924 Coenzyme A binding pocket [chemical binding]; other site 420246004925 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 420246004926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004927 Coenzyme A binding pocket [chemical binding]; other site 420246004928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246004929 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 420246004930 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 420246004931 putative [4Fe-4S] binding site [ion binding]; other site 420246004932 putative molybdopterin cofactor binding site [chemical binding]; other site 420246004933 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 420246004934 putative molybdopterin cofactor binding site; other site 420246004935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 420246004936 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 420246004937 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 420246004938 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 420246004939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004940 Coenzyme A binding pocket [chemical binding]; other site 420246004941 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 420246004942 AAA domain; Region: AAA_18; pfam13238 420246004943 active site 420246004944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 420246004945 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 420246004946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246004947 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246004948 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 420246004949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246004950 Coenzyme A binding pocket [chemical binding]; other site 420246004951 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 420246004952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246004953 Transposase; Region: HTH_Tnp_1; pfam01527 420246004954 HTH-like domain; Region: HTH_21; pfam13276 420246004955 Integrase core domain; Region: rve; pfam00665 420246004956 HTH-like domain; Region: HTH_21; pfam13276 420246004957 Integrase core domain; Region: rve; pfam00665 420246004958 Integrase core domain; Region: rve_3; pfam13683 420246004959 Uncharacterized conserved protein [Function unknown]; Region: COG4127 420246004960 Restriction endonuclease; Region: Mrr_cat; pfam04471 420246004961 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 420246004962 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 420246004963 DNA binding residues [nucleotide binding] 420246004964 dimer interface [polypeptide binding]; other site 420246004965 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 420246004966 active site 420246004967 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 420246004968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246004969 dimerization interface [polypeptide binding]; other site 420246004970 putative DNA binding site [nucleotide binding]; other site 420246004971 putative Zn2+ binding site [ion binding]; other site 420246004972 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 420246004973 arsenical-resistance protein; Region: acr3; TIGR00832 420246004974 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 420246004975 Low molecular weight phosphatase family; Region: LMWPc; cd00115 420246004976 active site 420246004977 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 420246004978 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 420246004979 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 420246004980 MarR family; Region: MarR_2; pfam12802 420246004981 Predicted permeases [General function prediction only]; Region: COG0701 420246004982 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 420246004983 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 420246004984 Coenzyme A binding pocket [chemical binding]; other site 420246004985 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 420246004986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246004987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246004988 dimerization interface [polypeptide binding]; other site 420246004989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246004990 dimer interface [polypeptide binding]; other site 420246004991 phosphorylation site [posttranslational modification] 420246004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246004993 ATP binding site [chemical binding]; other site 420246004994 Mg2+ binding site [ion binding]; other site 420246004995 G-X-G motif; other site 420246004996 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246004997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246004998 active site 420246004999 phosphorylation site [posttranslational modification] 420246005000 intermolecular recognition site; other site 420246005001 dimerization interface [polypeptide binding]; other site 420246005002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246005003 DNA binding site [nucleotide binding] 420246005004 Uncharacterized conserved protein [Function unknown]; Region: COG0398 420246005005 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 420246005006 Family description; Region: DsbD_2; pfam13386 420246005007 Predicted membrane protein [Function unknown]; Region: COG3462 420246005008 Short C-terminal domain; Region: SHOCT; pfam09851 420246005009 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 420246005010 putative homodimer interface [polypeptide binding]; other site 420246005011 putative homotetramer interface [polypeptide binding]; other site 420246005012 allosteric switch controlling residues; other site 420246005013 putative metal binding site [ion binding]; other site 420246005014 putative homodimer-homodimer interface [polypeptide binding]; other site 420246005015 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 420246005016 metal-binding site [ion binding] 420246005017 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 420246005018 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 420246005019 Multicopper oxidase; Region: Cu-oxidase; pfam00394 420246005020 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 420246005021 SIR2-like domain; Region: SIR2_2; pfam13289 420246005022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246005023 Transposase; Region: HTH_Tnp_1; pfam01527 420246005024 HTH-like domain; Region: HTH_21; pfam13276 420246005025 Integrase core domain; Region: rve; pfam00665 420246005026 Integrase core domain; Region: rve_3; pfam13683 420246005027 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246005028 DNA binding site [nucleotide binding] 420246005029 active site 420246005030 Int/Topo IB signature motif; other site 420246005031 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 420246005032 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246005033 active site 420246005034 DNA binding site [nucleotide binding] 420246005035 Int/Topo IB signature motif; other site 420246005036 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 420246005037 DHH family; Region: DHH; pfam01368 420246005038 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 420246005039 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 420246005040 metal ion-dependent adhesion site (MIDAS); other site 420246005041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246005042 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 420246005043 Walker A motif; other site 420246005044 ATP binding site [chemical binding]; other site 420246005045 Walker B motif; other site 420246005046 arginine finger; other site 420246005047 Replication terminator protein; Region: RTP; pfam02334 420246005048 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 420246005049 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 420246005050 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 420246005051 putative active site [active] 420246005052 putative substrate binding site [chemical binding]; other site 420246005053 putative cosubstrate binding site; other site 420246005054 catalytic site [active] 420246005055 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 420246005056 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 420246005057 heme-binding site [chemical binding]; other site 420246005058 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 420246005059 FAD binding pocket [chemical binding]; other site 420246005060 FAD binding motif [chemical binding]; other site 420246005061 phosphate binding motif [ion binding]; other site 420246005062 beta-alpha-beta structure motif; other site 420246005063 NAD binding pocket [chemical binding]; other site 420246005064 Heme binding pocket [chemical binding]; other site 420246005065 Transcriptional regulator; Region: Rrf2; cl17282 420246005066 Rrf2 family protein; Region: rrf2_super; TIGR00738 420246005067 spermidine synthase; Provisional; Region: PRK00811 420246005068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246005069 S-adenosylmethionine binding site [chemical binding]; other site 420246005070 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 420246005071 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 420246005072 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 420246005073 active site 420246005074 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 420246005075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 420246005076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246005077 catalytic residue [active] 420246005078 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 420246005079 active site 420246005080 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 420246005081 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 420246005082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246005083 DNA-binding site [nucleotide binding]; DNA binding site 420246005084 UTRA domain; Region: UTRA; pfam07702 420246005085 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 420246005086 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 420246005087 Ca binding site [ion binding]; other site 420246005088 active site 420246005089 catalytic site [active] 420246005090 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 420246005091 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 420246005092 active site turn [active] 420246005093 phosphorylation site [posttranslational modification] 420246005094 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 420246005095 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 420246005096 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg1; cd04764 420246005097 DNA binding residues [nucleotide binding] 420246005098 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 420246005099 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 420246005100 CAP-like domain; other site 420246005101 active site 420246005102 primary dimer interface [polypeptide binding]; other site 420246005103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246005104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246005105 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 420246005106 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 420246005107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246005108 ATP binding site [chemical binding]; other site 420246005109 Mg2+ binding site [ion binding]; other site 420246005110 G-X-G motif; other site 420246005111 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 420246005112 anchoring element; other site 420246005113 dimer interface [polypeptide binding]; other site 420246005114 ATP binding site [chemical binding]; other site 420246005115 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 420246005116 active site 420246005117 putative metal-binding site [ion binding]; other site 420246005118 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 420246005119 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 420246005120 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 420246005121 ABC1 family; Region: ABC1; pfam03109 420246005122 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 420246005123 active site 420246005124 ATP binding site [chemical binding]; other site 420246005125 Uncharacterized conserved protein [Function unknown]; Region: COG3937 420246005126 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246005127 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 420246005128 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 420246005129 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 420246005130 Moco binding site; other site 420246005131 metal coordination site [ion binding]; other site 420246005132 Predicted membrane protein [Function unknown]; Region: COG3601 420246005133 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 420246005134 threonine synthase; Validated; Region: PRK08197 420246005135 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 420246005136 homodimer interface [polypeptide binding]; other site 420246005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246005138 catalytic residue [active] 420246005139 peptidase T; Region: peptidase-T; TIGR01882 420246005140 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 420246005141 metal binding site [ion binding]; metal-binding site 420246005142 dimer interface [polypeptide binding]; other site 420246005143 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 420246005144 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 420246005145 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 420246005146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246005147 S-adenosylmethionine binding site [chemical binding]; other site 420246005148 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 420246005149 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 420246005150 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 420246005151 active site 420246005152 catalytic triad [active] 420246005153 oxyanion hole [active] 420246005154 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 420246005155 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 420246005156 Cu(I) binding site [ion binding]; other site 420246005157 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 420246005158 threonine dehydratase; Validated; Region: PRK08639 420246005159 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 420246005160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246005161 tetramer interface [polypeptide binding]; other site 420246005162 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 420246005163 putative Ile/Val binding site [chemical binding]; other site 420246005164 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 420246005165 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 420246005166 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 420246005167 folate binding site [chemical binding]; other site 420246005168 NADP+ binding site [chemical binding]; other site 420246005169 thymidylate synthase; Reviewed; Region: thyA; PRK01827 420246005170 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 420246005171 dimerization interface [polypeptide binding]; other site 420246005172 active site 420246005173 YpjP-like protein; Region: YpjP; pfam14005 420246005174 aspartate aminotransferase; Provisional; Region: PRK07681 420246005175 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246005176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246005177 homodimer interface [polypeptide binding]; other site 420246005178 catalytic residue [active] 420246005179 YuzL-like protein; Region: YuzL; pfam14115 420246005180 Disulphide isomerase; Region: Disulph_isomer; pfam06491 420246005181 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 420246005182 Virulence factor; Region: Virulence_fact; pfam13769 420246005183 HEAT repeats; Region: HEAT_2; pfam13646 420246005184 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 420246005185 HEAT repeats; Region: HEAT_2; pfam13646 420246005186 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 420246005187 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 420246005188 dimer interface [polypeptide binding]; other site 420246005189 catalytic residues [active] 420246005190 Homoserine O-succinyltransferase; Region: HTS; pfam04204 420246005191 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 420246005192 proposed active site lysine [active] 420246005193 conserved cys residue [active] 420246005194 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 420246005195 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 420246005196 active site 420246005197 SAM binding site [chemical binding]; other site 420246005198 homodimer interface [polypeptide binding]; other site 420246005199 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 420246005200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 420246005201 putative dimer interface [polypeptide binding]; other site 420246005202 active site pocket [active] 420246005203 putative cataytic base [active] 420246005204 cobyric acid synthase; Provisional; Region: PRK00784 420246005205 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 420246005206 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 420246005207 catalytic triad [active] 420246005208 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 420246005209 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 420246005210 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 420246005211 catalytic triad [active] 420246005212 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 420246005213 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 420246005214 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 420246005215 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 420246005216 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 420246005217 active site 420246005218 SAM binding site [chemical binding]; other site 420246005219 homodimer interface [polypeptide binding]; other site 420246005220 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 420246005221 active site 420246005222 SAM binding site [chemical binding]; other site 420246005223 homodimer interface [polypeptide binding]; other site 420246005224 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 420246005225 active site 420246005226 putative homodimer interface [polypeptide binding]; other site 420246005227 SAM binding site [chemical binding]; other site 420246005228 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 420246005229 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 420246005230 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 420246005231 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 420246005232 Precorrin-8X methylmutase; Region: CbiC; pfam02570 420246005233 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 420246005234 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 420246005235 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 420246005236 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 420246005237 putative active site [active] 420246005238 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 420246005239 putative active site [active] 420246005240 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 420246005241 active site 420246005242 SAM binding site [chemical binding]; other site 420246005243 homodimer interface [polypeptide binding]; other site 420246005244 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 420246005245 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 420246005246 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 420246005247 Walker A/P-loop; other site 420246005248 ATP binding site [chemical binding]; other site 420246005249 Q-loop/lid; other site 420246005250 ABC transporter signature motif; other site 420246005251 Walker B; other site 420246005252 D-loop; other site 420246005253 H-loop/switch region; other site 420246005254 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 420246005255 cobalt transport protein CbiN; Provisional; Region: PRK02898 420246005256 cobalt transport protein CbiM; Validated; Region: PRK08319 420246005257 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 420246005258 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 420246005259 dimer interface [polypeptide binding]; other site 420246005260 [2Fe-2S] cluster binding site [ion binding]; other site 420246005261 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 420246005262 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 420246005263 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 420246005264 active site 420246005265 catalytic site [active] 420246005266 DNA topoisomerase III; Provisional; Region: PRK07726 420246005267 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 420246005268 active site 420246005269 putative interdomain interaction site [polypeptide binding]; other site 420246005270 putative metal-binding site [ion binding]; other site 420246005271 putative nucleotide binding site [chemical binding]; other site 420246005272 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 420246005273 domain I; other site 420246005274 DNA binding groove [nucleotide binding] 420246005275 phosphate binding site [ion binding]; other site 420246005276 domain II; other site 420246005277 domain III; other site 420246005278 nucleotide binding site [chemical binding]; other site 420246005279 catalytic site [active] 420246005280 domain IV; other site 420246005281 PADR1 (NUC008) domain; Region: PADR1; pfam08063 420246005282 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 420246005283 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 420246005284 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 420246005285 active site 420246005286 catalytic tetrad [active] 420246005287 oligoendopeptidase F; Region: pepF; TIGR00181 420246005288 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 420246005289 active site 420246005290 Zn binding site [ion binding]; other site 420246005291 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 420246005292 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 420246005293 active site 420246005294 Isochorismatase family; Region: Isochorismatase; pfam00857 420246005295 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 420246005296 catalytic triad [active] 420246005297 conserved cis-peptide bond; other site 420246005298 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 420246005299 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 420246005300 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 420246005301 putative active site [active] 420246005302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246005303 TPR motif; other site 420246005304 binding surface 420246005305 TPR repeat; Region: TPR_11; pfam13414 420246005306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246005307 binding surface 420246005308 TPR motif; other site 420246005309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246005310 binding surface 420246005311 TPR motif; other site 420246005312 TPR repeat; Region: TPR_11; pfam13414 420246005313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 420246005314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246005315 TPR motif; other site 420246005316 binding surface 420246005317 TPR repeat; Region: TPR_11; pfam13414 420246005318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246005319 binding surface 420246005320 TPR motif; other site 420246005321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246005322 binding surface 420246005323 TPR motif; other site 420246005324 Esterase/lipase [General function prediction only]; Region: COG1647 420246005325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 420246005326 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 420246005327 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 420246005328 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 420246005329 [4Fe-4S] binding site [ion binding]; other site 420246005330 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246005331 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246005332 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 420246005333 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 420246005334 molybdopterin cofactor binding site; other site 420246005335 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 420246005336 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 420246005337 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 420246005338 Hemerythrin-like domain; Region: Hr-like; cd12108 420246005339 Fe binding site [ion binding]; other site 420246005340 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 420246005341 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 420246005342 dimer interface [polypeptide binding]; other site 420246005343 PYR/PP interface [polypeptide binding]; other site 420246005344 TPP binding site [chemical binding]; other site 420246005345 substrate binding site [chemical binding]; other site 420246005346 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246005347 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 420246005348 TPP-binding site [chemical binding]; other site 420246005349 putative dimer interface [polypeptide binding]; other site 420246005350 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 420246005351 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 420246005352 4Fe-4S binding domain; Region: Fer4; pfam00037 420246005353 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 420246005354 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 420246005355 active site 420246005356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 420246005357 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 420246005358 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 420246005359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246005360 dimer interface [polypeptide binding]; other site 420246005361 phosphorylation site [posttranslational modification] 420246005362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246005363 ATP binding site [chemical binding]; other site 420246005364 Mg2+ binding site [ion binding]; other site 420246005365 G-X-G motif; other site 420246005366 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 420246005367 active site 420246005368 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 420246005369 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 420246005370 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 420246005371 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 420246005372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 420246005373 active site 420246005374 phosphorylation site [posttranslational modification] 420246005375 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 420246005376 active site 420246005377 P-loop; other site 420246005378 phosphorylation site [posttranslational modification] 420246005379 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 420246005380 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 420246005381 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 420246005382 putative substrate binding site [chemical binding]; other site 420246005383 putative ATP binding site [chemical binding]; other site 420246005384 Trp repressor protein; Region: Trp_repressor; cl17266 420246005385 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 420246005386 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 420246005387 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 420246005388 YtkA-like; Region: YtkA; pfam13115 420246005389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 420246005390 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 420246005391 Walker A/P-loop; other site 420246005392 ATP binding site [chemical binding]; other site 420246005393 Q-loop/lid; other site 420246005394 ABC transporter signature motif; other site 420246005395 Walker B; other site 420246005396 D-loop; other site 420246005397 H-loop/switch region; other site 420246005398 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 420246005399 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 420246005400 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 420246005401 Cytochrome c; Region: Cytochrom_C; pfam00034 420246005402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246005403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246005404 metal binding site [ion binding]; metal-binding site 420246005405 active site 420246005406 I-site; other site 420246005407 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 420246005408 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246005409 Zn2+ binding site [ion binding]; other site 420246005410 Mg2+ binding site [ion binding]; other site 420246005411 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 420246005412 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 420246005413 G1 box; other site 420246005414 GTP/Mg2+ binding site [chemical binding]; other site 420246005415 Switch I region; other site 420246005416 G2 box; other site 420246005417 G3 box; other site 420246005418 Switch II region; other site 420246005419 G4 box; other site 420246005420 G5 box; other site 420246005421 Nucleoside recognition; Region: Gate; pfam07670 420246005422 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 420246005423 Nucleoside recognition; Region: Gate; pfam07670 420246005424 FeoA domain; Region: FeoA; pfam04023 420246005425 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 420246005426 Sodium Bile acid symporter family; Region: SBF; pfam01758 420246005427 Endonuclease I; Region: Endonuclease_1; pfam04231 420246005428 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 420246005429 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 420246005430 putative active site [active] 420246005431 putative metal binding site [ion binding]; other site 420246005432 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 420246005433 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 420246005434 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 420246005435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246005436 DNA-binding site [nucleotide binding]; DNA binding site 420246005437 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 420246005438 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 420246005439 beta-galactosidase; Region: BGL; TIGR03356 420246005440 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 420246005441 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 420246005442 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 420246005443 active site 420246005444 methionine cluster; other site 420246005445 phosphorylation site [posttranslational modification] 420246005446 metal binding site [ion binding]; metal-binding site 420246005447 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 420246005448 active site 420246005449 P-loop; other site 420246005450 phosphorylation site [posttranslational modification] 420246005451 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 420246005452 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 420246005453 DNA binding residues [nucleotide binding] 420246005454 putative dimer interface [polypeptide binding]; other site 420246005455 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 420246005456 active site 420246005457 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 420246005458 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 420246005459 active site 420246005460 NAD binding site [chemical binding]; other site 420246005461 metal binding site [ion binding]; metal-binding site 420246005462 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 420246005463 Nitronate monooxygenase; Region: NMO; pfam03060 420246005464 FMN binding site [chemical binding]; other site 420246005465 substrate binding site [chemical binding]; other site 420246005466 putative catalytic residue [active] 420246005467 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 420246005468 N- and C-terminal domain interface [polypeptide binding]; other site 420246005469 D-xylulose kinase; Region: XylB; TIGR01312 420246005470 active site 420246005471 MgATP binding site [chemical binding]; other site 420246005472 catalytic site [active] 420246005473 metal binding site [ion binding]; metal-binding site 420246005474 xylulose binding site [chemical binding]; other site 420246005475 homodimer interface [polypeptide binding]; other site 420246005476 xylose isomerase; Provisional; Region: PRK05474 420246005477 xylose isomerase; Region: xylose_isom_A; TIGR02630 420246005478 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 420246005479 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 420246005480 inhibitor binding site; inhibition site 420246005481 active site 420246005482 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 420246005483 active site 420246005484 catalytic triad [active] 420246005485 oxyanion hole [active] 420246005486 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 420246005487 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 420246005488 Predicted integral membrane protein [Function unknown]; Region: COG5578 420246005489 D-mannonate oxidoreductase; Provisional; Region: PRK08277 420246005490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246005491 NAD(P) binding site [chemical binding]; other site 420246005492 active site 420246005493 mannonate dehydratase; Provisional; Region: PRK03906 420246005494 mannonate dehydratase; Region: uxuA; TIGR00695 420246005495 Glucuronate isomerase; Region: UxaC; pfam02614 420246005496 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 420246005497 Transcriptional regulators [Transcription]; Region: GntR; COG1802 420246005498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246005499 DNA-binding site [nucleotide binding]; DNA binding site 420246005500 FCD domain; Region: FCD; pfam07729 420246005501 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 420246005502 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 420246005503 active site 420246005504 intersubunit interface [polypeptide binding]; other site 420246005505 catalytic residue [active] 420246005506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 420246005507 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 420246005508 substrate binding site [chemical binding]; other site 420246005509 ATP binding site [chemical binding]; other site 420246005510 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 420246005511 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 420246005512 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 420246005513 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 420246005514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246005515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005516 dimer interface [polypeptide binding]; other site 420246005517 ABC-ATPase subunit interface; other site 420246005518 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 420246005519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005520 dimer interface [polypeptide binding]; other site 420246005521 conserved gate region; other site 420246005522 putative PBP binding loops; other site 420246005523 ABC-ATPase subunit interface; other site 420246005524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246005525 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 420246005526 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 420246005527 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 420246005528 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 420246005529 NodB motif; other site 420246005530 active site 420246005531 catalytic site [active] 420246005532 metal binding site [ion binding]; metal-binding site 420246005533 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 420246005534 active site 420246005535 catalytic residues [active] 420246005536 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246005537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005538 dimer interface [polypeptide binding]; other site 420246005539 conserved gate region; other site 420246005540 putative PBP binding loops; other site 420246005541 ABC-ATPase subunit interface; other site 420246005542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005543 dimer interface [polypeptide binding]; other site 420246005544 conserved gate region; other site 420246005545 putative PBP binding loops; other site 420246005546 ABC-ATPase subunit interface; other site 420246005547 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246005548 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246005549 Response regulator receiver domain; Region: Response_reg; pfam00072 420246005550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246005551 active site 420246005552 phosphorylation site [posttranslational modification] 420246005553 intermolecular recognition site; other site 420246005554 dimerization interface [polypeptide binding]; other site 420246005555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246005556 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 420246005557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246005558 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 420246005559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 420246005560 Histidine kinase; Region: His_kinase; pfam06580 420246005561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246005562 ATP binding site [chemical binding]; other site 420246005563 Mg2+ binding site [ion binding]; other site 420246005564 G-X-G motif; other site 420246005565 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246005566 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 420246005567 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 420246005568 active site 420246005569 metal binding site [ion binding]; metal-binding site 420246005570 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 420246005571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246005572 active site 420246005573 motif I; other site 420246005574 motif II; other site 420246005575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246005576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246005577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246005578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 420246005579 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 420246005580 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 420246005581 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246005582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005583 dimer interface [polypeptide binding]; other site 420246005584 conserved gate region; other site 420246005585 putative PBP binding loops; other site 420246005586 ABC-ATPase subunit interface; other site 420246005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005588 dimer interface [polypeptide binding]; other site 420246005589 conserved gate region; other site 420246005590 putative PBP binding loops; other site 420246005591 ABC-ATPase subunit interface; other site 420246005592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246005593 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 420246005594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246005595 L-arabinose isomerase; Provisional; Region: PRK02929 420246005596 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 420246005597 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 420246005598 trimer interface [polypeptide binding]; other site 420246005599 putative substrate binding site [chemical binding]; other site 420246005600 putative metal binding site [ion binding]; other site 420246005601 ribulokinase; Provisional; Region: PRK04123 420246005602 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 420246005603 N- and C-terminal domain interface [polypeptide binding]; other site 420246005604 active site 420246005605 MgATP binding site [chemical binding]; other site 420246005606 catalytic site [active] 420246005607 metal binding site [ion binding]; metal-binding site 420246005608 carbohydrate binding site [chemical binding]; other site 420246005609 homodimer interface [polypeptide binding]; other site 420246005610 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 420246005611 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 420246005612 intersubunit interface [polypeptide binding]; other site 420246005613 active site 420246005614 Zn2+ binding site [ion binding]; other site 420246005615 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 420246005616 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246005617 DNA-binding site [nucleotide binding]; DNA binding site 420246005618 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 420246005619 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 420246005620 putative dimerization interface [polypeptide binding]; other site 420246005621 putative ligand binding site [chemical binding]; other site 420246005622 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246005623 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 420246005624 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 420246005625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246005626 TM-ABC transporter signature motif; other site 420246005627 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 420246005628 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 420246005629 Walker A/P-loop; other site 420246005630 ATP binding site [chemical binding]; other site 420246005631 Q-loop/lid; other site 420246005632 ABC transporter signature motif; other site 420246005633 Walker B; other site 420246005634 D-loop; other site 420246005635 H-loop/switch region; other site 420246005636 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 420246005637 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 420246005638 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 420246005639 putative ligand binding site [chemical binding]; other site 420246005640 Response regulator receiver domain; Region: Response_reg; pfam00072 420246005641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246005642 active site 420246005643 phosphorylation site [posttranslational modification] 420246005644 intermolecular recognition site; other site 420246005645 dimerization interface [polypeptide binding]; other site 420246005646 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 420246005647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246005648 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 420246005649 Cache domain; Region: Cache_1; pfam02743 420246005650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246005651 dimerization interface [polypeptide binding]; other site 420246005652 Histidine kinase; Region: His_kinase; pfam06580 420246005653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246005654 ATP binding site [chemical binding]; other site 420246005655 Mg2+ binding site [ion binding]; other site 420246005656 G-X-G motif; other site 420246005657 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 420246005658 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 420246005659 ligand binding site [chemical binding]; other site 420246005660 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 420246005661 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 420246005662 intersubunit interface [polypeptide binding]; other site 420246005663 active site 420246005664 zinc binding site [ion binding]; other site 420246005665 Na+ binding site [ion binding]; other site 420246005666 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 420246005667 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 420246005668 tetrameric interface [polypeptide binding]; other site 420246005669 NAD binding site [chemical binding]; other site 420246005670 catalytic residues [active] 420246005671 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 420246005672 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 420246005673 substrate binding site [chemical binding]; other site 420246005674 ATP binding site [chemical binding]; other site 420246005675 KduI/IolB family; Region: KduI; pfam04962 420246005676 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 420246005677 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 420246005678 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 420246005679 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 420246005680 PYR/PP interface [polypeptide binding]; other site 420246005681 dimer interface [polypeptide binding]; other site 420246005682 TPP binding site [chemical binding]; other site 420246005683 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 420246005684 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 420246005685 TPP-binding site; other site 420246005686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246005687 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246005688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 420246005689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246005690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246005691 DNA binding site [nucleotide binding] 420246005692 domain linker motif; other site 420246005693 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 420246005694 dimerization interface [polypeptide binding]; other site 420246005695 ligand binding site [chemical binding]; other site 420246005696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 420246005697 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 420246005698 putative ligand binding site [chemical binding]; other site 420246005699 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246005700 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 420246005701 TM-ABC transporter signature motif; other site 420246005702 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 420246005703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246005704 Walker A/P-loop; other site 420246005705 ATP binding site [chemical binding]; other site 420246005706 Q-loop/lid; other site 420246005707 ABC transporter signature motif; other site 420246005708 Walker B; other site 420246005709 D-loop; other site 420246005710 H-loop/switch region; other site 420246005711 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 420246005712 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246005713 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246005714 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 420246005715 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246005716 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246005717 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 420246005718 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 420246005719 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 420246005720 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 420246005721 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 420246005722 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 420246005723 active site 420246005724 catalytic site [active] 420246005725 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 420246005726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246005727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005728 dimer interface [polypeptide binding]; other site 420246005729 conserved gate region; other site 420246005730 putative PBP binding loops; other site 420246005731 ABC-ATPase subunit interface; other site 420246005732 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 420246005733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246005734 dimer interface [polypeptide binding]; other site 420246005735 conserved gate region; other site 420246005736 putative PBP binding loops; other site 420246005737 ABC-ATPase subunit interface; other site 420246005738 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246005739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246005740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246005741 DNA-binding site [nucleotide binding]; DNA binding site 420246005742 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246005743 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 420246005744 dimerization interface [polypeptide binding]; other site 420246005745 ligand binding site [chemical binding]; other site 420246005746 enoyl-CoA hydratase; Provisional; Region: PRK07659 420246005747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246005748 substrate binding site [chemical binding]; other site 420246005749 oxyanion hole (OAH) forming residues; other site 420246005750 trimer interface [polypeptide binding]; other site 420246005751 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246005752 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 420246005753 NAD(P) binding site [chemical binding]; other site 420246005754 catalytic residues [active] 420246005755 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 420246005756 Na binding site [ion binding]; other site 420246005757 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 420246005758 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 420246005759 inhibitor-cofactor binding pocket; inhibition site 420246005760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246005761 catalytic residue [active] 420246005762 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246005763 PAS domain; Region: PAS_9; pfam13426 420246005764 putative active site [active] 420246005765 heme pocket [chemical binding]; other site 420246005766 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 420246005767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246005768 Walker A motif; other site 420246005769 ATP binding site [chemical binding]; other site 420246005770 Walker B motif; other site 420246005771 arginine finger; other site 420246005772 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 420246005773 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 420246005774 agmatinase; Region: agmatinase; TIGR01230 420246005775 oligomer interface [polypeptide binding]; other site 420246005776 putative active site [active] 420246005777 Mn binding site [ion binding]; other site 420246005778 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 420246005779 maltose O-acetyltransferase; Provisional; Region: PRK10092 420246005780 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 420246005781 active site 420246005782 substrate binding site [chemical binding]; other site 420246005783 trimer interface [polypeptide binding]; other site 420246005784 CoA binding site [chemical binding]; other site 420246005785 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 420246005786 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 420246005787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246005788 catalytic residue [active] 420246005789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246005790 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 420246005791 Coenzyme A binding pocket [chemical binding]; other site 420246005792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246005793 fructuronate transporter; Provisional; Region: PRK10034; cl15264 420246005794 GntP family permease; Region: GntP_permease; pfam02447 420246005795 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 420246005796 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 420246005797 N- and C-terminal domain interface [polypeptide binding]; other site 420246005798 active site 420246005799 catalytic site [active] 420246005800 metal binding site [ion binding]; metal-binding site 420246005801 carbohydrate binding site [chemical binding]; other site 420246005802 ATP binding site [chemical binding]; other site 420246005803 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246005804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246005805 DNA binding site [nucleotide binding] 420246005806 domain linker motif; other site 420246005807 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 420246005808 putative dimerization interface [polypeptide binding]; other site 420246005809 putative ligand binding site [chemical binding]; other site 420246005810 Predicted permeases [General function prediction only]; Region: COG0679 420246005811 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 420246005812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246005813 active site 420246005814 phosphorylation site [posttranslational modification] 420246005815 intermolecular recognition site; other site 420246005816 dimerization interface [polypeptide binding]; other site 420246005817 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 420246005818 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 420246005819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246005820 putative active site [active] 420246005821 heme pocket [chemical binding]; other site 420246005822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246005823 ATP binding site [chemical binding]; other site 420246005824 Mg2+ binding site [ion binding]; other site 420246005825 G-X-G motif; other site 420246005826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 420246005827 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 420246005828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 420246005829 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 420246005830 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 420246005831 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 420246005832 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 420246005833 active site 420246005834 phosphorylation site [posttranslational modification] 420246005835 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 420246005836 HTH domain; Region: HTH_11; pfam08279 420246005837 PRD domain; Region: PRD; pfam00874 420246005838 PRD domain; Region: PRD; pfam00874 420246005839 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 420246005840 active site 420246005841 P-loop; other site 420246005842 phosphorylation site [posttranslational modification] 420246005843 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 420246005844 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 420246005845 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 420246005846 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 420246005847 active site 420246005848 P-loop; other site 420246005849 phosphorylation site [posttranslational modification] 420246005850 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 420246005851 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 420246005852 tetrameric interface [polypeptide binding]; other site 420246005853 NAD binding site [chemical binding]; other site 420246005854 catalytic residues [active] 420246005855 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 420246005856 fructuronate transporter; Provisional; Region: PRK10034; cl15264 420246005857 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 420246005858 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 420246005859 active site 420246005860 NAD binding site [chemical binding]; other site 420246005861 metal binding site [ion binding]; metal-binding site 420246005862 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 420246005863 PAS fold; Region: PAS; pfam00989 420246005864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246005865 putative active site [active] 420246005866 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 420246005867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246005868 Walker A motif; other site 420246005869 ATP binding site [chemical binding]; other site 420246005870 Walker B motif; other site 420246005871 arginine finger; other site 420246005872 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 420246005873 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 420246005874 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 420246005875 ligand binding site [chemical binding]; other site 420246005876 NAD binding site [chemical binding]; other site 420246005877 catalytic site [active] 420246005878 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 420246005879 galactonate dehydratase; Provisional; Region: PRK14017 420246005880 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 420246005881 putative active site pocket [active] 420246005882 putative metal binding site [ion binding]; other site 420246005883 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 420246005884 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 420246005885 active site 420246005886 intersubunit interface [polypeptide binding]; other site 420246005887 catalytic residue [active] 420246005888 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 420246005889 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 420246005890 substrate binding site [chemical binding]; other site 420246005891 ATP binding site [chemical binding]; other site 420246005892 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 420246005893 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 420246005894 Peptidase family U32; Region: Peptidase_U32; cl03113 420246005895 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 420246005896 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 420246005897 inhibitor site; inhibition site 420246005898 active site 420246005899 dimer interface [polypeptide binding]; other site 420246005900 catalytic residue [active] 420246005901 hypothetical protein; Provisional; Region: PRK04194 420246005902 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 420246005903 AIR carboxylase; Region: AIRC; smart01001 420246005904 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 420246005905 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 420246005906 Ligand Binding Site [chemical binding]; other site 420246005907 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 420246005908 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246005909 NAD(P) binding site [chemical binding]; other site 420246005910 catalytic residues [active] 420246005911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 420246005912 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 420246005913 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 420246005914 Transcriptional regulator [Transcription]; Region: IclR; COG1414 420246005915 Bacterial transcriptional regulator; Region: IclR; pfam01614 420246005916 Dehydratase family; Region: ILVD_EDD; cl00340 420246005917 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 420246005918 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 420246005919 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 420246005920 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 420246005921 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 420246005922 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 420246005923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 420246005924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 420246005925 active site 420246005926 catalytic tetrad [active] 420246005927 Uncharacterized conserved protein [Function unknown]; Region: COG3589 420246005928 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 420246005929 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 420246005930 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 420246005931 active site turn [active] 420246005932 phosphorylation site [posttranslational modification] 420246005933 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 420246005934 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 420246005935 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 420246005936 putative active site [active] 420246005937 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 420246005938 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 420246005939 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 420246005940 putative active site [active] 420246005941 Uncharacterized conserved protein [Function unknown]; Region: COG2353 420246005942 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 420246005943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246005944 NAD(P) binding site [chemical binding]; other site 420246005945 active site 420246005946 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 420246005947 aromatic arch; other site 420246005948 DCoH dimer interaction site [polypeptide binding]; other site 420246005949 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 420246005950 DCoH tetramer interaction site [polypeptide binding]; other site 420246005951 substrate binding site [chemical binding]; other site 420246005952 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 420246005953 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 420246005954 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 420246005955 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 420246005956 active site 420246005957 catalytic triad [active] 420246005958 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 420246005959 Sodium Bile acid symporter family; Region: SBF; cl17470 420246005960 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 420246005961 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 420246005962 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 420246005963 active site 420246005964 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 420246005965 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 420246005966 active site 420246005967 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 420246005968 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 420246005969 dimer interface [polypeptide binding]; other site 420246005970 acyl-activating enzyme (AAE) consensus motif; other site 420246005971 putative active site [active] 420246005972 putative AMP binding site [chemical binding]; other site 420246005973 putative CoA binding site [chemical binding]; other site 420246005974 chemical substrate binding site [chemical binding]; other site 420246005975 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 420246005976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246005977 substrate binding site [chemical binding]; other site 420246005978 oxyanion hole (OAH) forming residues; other site 420246005979 trimer interface [polypeptide binding]; other site 420246005980 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 420246005981 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 420246005982 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 420246005983 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 420246005984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246005985 PaaX-like protein; Region: PaaX; pfam07848 420246005986 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 420246005987 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 420246005988 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 420246005989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246005990 substrate binding site [chemical binding]; other site 420246005991 oxyanion hole (OAH) forming residues; other site 420246005992 trimer interface [polypeptide binding]; other site 420246005993 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 420246005994 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246005995 NAD(P) binding site [chemical binding]; other site 420246005996 catalytic residues [active] 420246005997 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 420246005998 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 420246005999 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 420246006000 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 420246006001 putative active site [active] 420246006002 putative metal binding site [ion binding]; other site 420246006003 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 420246006004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246006005 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 420246006006 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 420246006007 alpha subunit interface [polypeptide binding]; other site 420246006008 TPP binding site [chemical binding]; other site 420246006009 heterodimer interface [polypeptide binding]; other site 420246006010 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246006011 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 420246006012 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 420246006013 TPP-binding site [chemical binding]; other site 420246006014 tetramer interface [polypeptide binding]; other site 420246006015 heterodimer interface [polypeptide binding]; other site 420246006016 phosphorylation loop region [posttranslational modification] 420246006017 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 420246006018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246006019 Walker A/P-loop; other site 420246006020 ATP binding site [chemical binding]; other site 420246006021 Q-loop/lid; other site 420246006022 ABC transporter signature motif; other site 420246006023 Walker B; other site 420246006024 D-loop; other site 420246006025 H-loop/switch region; other site 420246006026 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246006027 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 420246006028 TM-ABC transporter signature motif; other site 420246006029 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 420246006030 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 420246006031 zinc binding site [ion binding]; other site 420246006032 putative ligand binding site [chemical binding]; other site 420246006033 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 420246006034 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 420246006035 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 420246006036 NAD binding site [chemical binding]; other site 420246006037 Phe binding site; other site 420246006038 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 420246006039 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 420246006040 FMN binding site [chemical binding]; other site 420246006041 substrate binding site [chemical binding]; other site 420246006042 putative catalytic residue [active] 420246006043 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 420246006044 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 420246006045 trimer interface [polypeptide binding]; other site 420246006046 putative metal binding site [ion binding]; other site 420246006047 PaaX-like protein; Region: PaaX; pfam07848 420246006048 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 420246006049 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 420246006050 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 420246006051 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 420246006052 dimer interface [polypeptide binding]; other site 420246006053 active site 420246006054 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 420246006055 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 420246006056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 420246006057 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 420246006058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246006059 NAD(P) binding site [chemical binding]; other site 420246006060 catalytic residues [active] 420246006061 enoyl-CoA hydratase; Provisional; Region: PRK08140 420246006062 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246006063 substrate binding site [chemical binding]; other site 420246006064 oxyanion hole (OAH) forming residues; other site 420246006065 trimer interface [polypeptide binding]; other site 420246006066 enoyl-CoA hydratase; Provisional; Region: PRK05862 420246006067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246006068 substrate binding site [chemical binding]; other site 420246006069 oxyanion hole (OAH) forming residues; other site 420246006070 trimer interface [polypeptide binding]; other site 420246006071 conserved hypothetical protein; Region: TIGR02118 420246006072 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 420246006073 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 420246006074 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 420246006075 Phenylacetic acid degradation B; Region: PaaB; cl01371 420246006076 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 420246006077 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 420246006078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 420246006079 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 420246006080 acyl-activating enzyme (AAE) consensus motif; other site 420246006081 AMP binding site [chemical binding]; other site 420246006082 active site 420246006083 CoA binding site [chemical binding]; other site 420246006084 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 420246006085 gamma-glutamyl kinase; Provisional; Region: PRK05429 420246006086 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 420246006087 nucleotide binding site [chemical binding]; other site 420246006088 homotetrameric interface [polypeptide binding]; other site 420246006089 putative phosphate binding site [ion binding]; other site 420246006090 putative allosteric binding site; other site 420246006091 PUA domain; Region: PUA; pfam01472 420246006092 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 420246006093 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 420246006094 putative catalytic cysteine [active] 420246006095 Predicted membrane protein [Function unknown]; Region: COG2246 420246006096 GtrA-like protein; Region: GtrA; pfam04138 420246006097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 420246006098 shikimate kinase; Reviewed; Region: aroK; PRK00131 420246006099 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 420246006100 ADP binding site [chemical binding]; other site 420246006101 magnesium binding site [ion binding]; other site 420246006102 putative shikimate binding site; other site 420246006103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246006104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246006105 DNA binding site [nucleotide binding] 420246006106 domain linker motif; other site 420246006107 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 420246006108 putative dimerization interface [polypeptide binding]; other site 420246006109 putative ligand binding site [chemical binding]; other site 420246006110 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 420246006111 CoA-transferase family III; Region: CoA_transf_3; pfam02515 420246006112 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 420246006113 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 420246006114 active site 420246006115 catalytic residue [active] 420246006116 dimer interface [polypeptide binding]; other site 420246006117 Transcriptional regulator [Transcription]; Region: IclR; COG1414 420246006118 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 420246006119 Bacterial transcriptional regulator; Region: IclR; pfam01614 420246006120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246006121 D-galactonate transporter; Region: 2A0114; TIGR00893 420246006122 putative substrate translocation pore; other site 420246006123 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 420246006124 DctM-like transporters; Region: DctM; pfam06808 420246006125 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 420246006126 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 420246006127 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 420246006128 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 420246006129 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 420246006130 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 420246006131 PYR/PP interface [polypeptide binding]; other site 420246006132 dimer interface [polypeptide binding]; other site 420246006133 TPP binding site [chemical binding]; other site 420246006134 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 420246006135 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 420246006136 TPP-binding site [chemical binding]; other site 420246006137 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 420246006138 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 420246006139 NAD(P) binding site [chemical binding]; other site 420246006140 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246006141 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 420246006142 NAD(P) binding site [chemical binding]; other site 420246006143 catalytic residues [active] 420246006144 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 420246006145 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 420246006146 active site 420246006147 oxalacetate binding site [chemical binding]; other site 420246006148 citrylCoA binding site [chemical binding]; other site 420246006149 coenzyme A binding site [chemical binding]; other site 420246006150 catalytic triad [active] 420246006151 Transposase, Mutator family; Region: Transposase_mut; pfam00872 420246006152 MULE transposase domain; Region: MULE; pfam10551 420246006153 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 420246006154 DNA polymerase IV; Reviewed; Region: PRK03103 420246006155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246006156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246006157 active site 420246006158 phosphorylation site [posttranslational modification] 420246006159 intermolecular recognition site; other site 420246006160 dimerization interface [polypeptide binding]; other site 420246006161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246006162 DNA binding site [nucleotide binding] 420246006163 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 420246006164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246006165 dimerization interface [polypeptide binding]; other site 420246006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246006167 dimer interface [polypeptide binding]; other site 420246006168 phosphorylation site [posttranslational modification] 420246006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246006170 ATP binding site [chemical binding]; other site 420246006171 Mg2+ binding site [ion binding]; other site 420246006172 G-X-G motif; other site 420246006173 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 420246006174 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 420246006175 Walker A/P-loop; other site 420246006176 ATP binding site [chemical binding]; other site 420246006177 Q-loop/lid; other site 420246006178 ABC transporter signature motif; other site 420246006179 Walker B; other site 420246006180 D-loop; other site 420246006181 H-loop/switch region; other site 420246006182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 420246006183 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 420246006184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 420246006185 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 420246006186 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 420246006187 active site 420246006188 catalytic residues [active] 420246006189 DNA binding site [nucleotide binding] 420246006190 Int/Topo IB signature motif; other site 420246006191 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 420246006192 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 420246006193 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 420246006194 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 420246006195 Catalytic site [active] 420246006196 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 420246006197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246006198 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 420246006199 active site 420246006200 motif I; other site 420246006201 motif II; other site 420246006202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246006203 EamA-like transporter family; Region: EamA; cl17759 420246006204 CobD/Cbib protein; Region: CobD_Cbib; cl00561 420246006205 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 420246006206 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 420246006207 putative di-iron ligands [ion binding]; other site 420246006208 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 420246006209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 420246006210 active site residue [active] 420246006211 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246006212 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 420246006213 CPxP motif; other site 420246006214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 420246006215 active site residue [active] 420246006216 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 420246006217 active site residue [active] 420246006218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 420246006219 active site residue [active] 420246006220 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 420246006221 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 420246006222 CPxP motif; other site 420246006223 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 420246006224 putative homodimer interface [polypeptide binding]; other site 420246006225 putative homotetramer interface [polypeptide binding]; other site 420246006226 putative metal binding site [ion binding]; other site 420246006227 putative homodimer-homodimer interface [polypeptide binding]; other site 420246006228 putative allosteric switch controlling residues; other site 420246006229 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 420246006230 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 420246006231 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 420246006232 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 420246006233 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 420246006234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 420246006235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 420246006236 Probable transposase; Region: OrfB_IS605; pfam01385 420246006237 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 420246006238 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246006239 Walker A/P-loop; other site 420246006240 ATP binding site [chemical binding]; other site 420246006241 Q-loop/lid; other site 420246006242 ABC transporter signature motif; other site 420246006243 Walker B; other site 420246006244 D-loop; other site 420246006245 H-loop/switch region; other site 420246006246 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246006247 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 420246006248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246006249 Walker A/P-loop; other site 420246006250 ATP binding site [chemical binding]; other site 420246006251 Q-loop/lid; other site 420246006252 ABC transporter signature motif; other site 420246006253 Walker B; other site 420246006254 D-loop; other site 420246006255 H-loop/switch region; other site 420246006256 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246006257 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 420246006258 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 420246006259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006260 dimer interface [polypeptide binding]; other site 420246006261 conserved gate region; other site 420246006262 putative PBP binding loops; other site 420246006263 ABC-ATPase subunit interface; other site 420246006264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 420246006265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006266 dimer interface [polypeptide binding]; other site 420246006267 conserved gate region; other site 420246006268 putative PBP binding loops; other site 420246006269 ABC-ATPase subunit interface; other site 420246006270 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 420246006271 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 420246006272 Uncharacterized conserved protein [Function unknown]; Region: COG5476 420246006273 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 420246006274 MlrC C-terminus; Region: MlrC_C; pfam07171 420246006275 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 420246006276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 420246006277 dimer interface [polypeptide binding]; other site 420246006278 active site 420246006279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 420246006280 substrate binding site [chemical binding]; other site 420246006281 catalytic residue [active] 420246006282 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 420246006283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 420246006284 dimer interface [polypeptide binding]; other site 420246006285 putative CheW interface [polypeptide binding]; other site 420246006286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246006287 Coenzyme A binding pocket [chemical binding]; other site 420246006288 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 420246006289 PLD-like domain; Region: PLDc_2; pfam13091 420246006290 putative homodimer interface [polypeptide binding]; other site 420246006291 putative active site [active] 420246006292 catalytic site [active] 420246006293 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 420246006294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246006295 ATP binding site [chemical binding]; other site 420246006296 putative Mg++ binding site [ion binding]; other site 420246006297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246006298 nucleotide binding region [chemical binding]; other site 420246006299 ATP-binding site [chemical binding]; other site 420246006300 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 420246006301 metal binding site [ion binding]; metal-binding site 420246006302 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 420246006303 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 420246006304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246006305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246006306 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 420246006307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246006308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246006309 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 420246006310 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246006311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246006312 DNA binding site [nucleotide binding] 420246006313 domain linker motif; other site 420246006314 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 420246006315 dimerization interface [polypeptide binding]; other site 420246006316 ligand binding site [chemical binding]; other site 420246006317 metabolite-proton symporter; Region: 2A0106; TIGR00883 420246006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246006319 putative substrate translocation pore; other site 420246006320 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 420246006321 homodimer interaction site [polypeptide binding]; other site 420246006322 putative active site [active] 420246006323 putative catalytic site [active] 420246006324 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246006325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006326 dimer interface [polypeptide binding]; other site 420246006327 conserved gate region; other site 420246006328 putative PBP binding loops; other site 420246006329 ABC-ATPase subunit interface; other site 420246006330 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 420246006331 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 420246006332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006333 dimer interface [polypeptide binding]; other site 420246006334 conserved gate region; other site 420246006335 putative PBP binding loops; other site 420246006336 ABC-ATPase subunit interface; other site 420246006337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246006338 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246006339 glutaminase A; Region: Gln_ase; TIGR03814 420246006340 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 420246006341 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 420246006342 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 420246006343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 420246006344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 420246006345 dimer interface [polypeptide binding]; other site 420246006346 putative metal binding site [ion binding]; other site 420246006347 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 420246006348 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 420246006349 Predicted integral membrane protein [Function unknown]; Region: COG5658 420246006350 SdpI/YhfL protein family; Region: SdpI; pfam13630 420246006351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246006352 dimerization interface [polypeptide binding]; other site 420246006353 putative DNA binding site [nucleotide binding]; other site 420246006354 putative Zn2+ binding site [ion binding]; other site 420246006355 Predicted membrane protein [Function unknown]; Region: COG2259 420246006356 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 420246006357 Na binding site [ion binding]; other site 420246006358 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 420246006359 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 420246006360 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 420246006361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246006362 NAD(P) binding site [chemical binding]; other site 420246006363 active site 420246006364 NMT1/THI5 like; Region: NMT1; pfam09084 420246006365 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 420246006366 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 420246006367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006368 dimer interface [polypeptide binding]; other site 420246006369 conserved gate region; other site 420246006370 putative PBP binding loops; other site 420246006371 ABC-ATPase subunit interface; other site 420246006372 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 420246006373 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 420246006374 Walker A/P-loop; other site 420246006375 ATP binding site [chemical binding]; other site 420246006376 Q-loop/lid; other site 420246006377 ABC transporter signature motif; other site 420246006378 Walker B; other site 420246006379 D-loop; other site 420246006380 H-loop/switch region; other site 420246006381 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 420246006382 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 420246006383 putative catalytic cysteine [active] 420246006384 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 420246006385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246006386 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246006387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 420246006388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006389 dimer interface [polypeptide binding]; other site 420246006390 conserved gate region; other site 420246006391 putative PBP binding loops; other site 420246006392 ABC-ATPase subunit interface; other site 420246006393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 420246006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246006395 dimer interface [polypeptide binding]; other site 420246006396 conserved gate region; other site 420246006397 putative PBP binding loops; other site 420246006398 ABC-ATPase subunit interface; other site 420246006399 TPR repeat; Region: TPR_11; pfam13414 420246006400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246006401 binding surface 420246006402 TPR motif; other site 420246006403 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 420246006404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246006405 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246006406 DNA adenine methylase (dam); Region: dam; TIGR00571 420246006407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246006408 non-specific DNA binding site [nucleotide binding]; other site 420246006409 salt bridge; other site 420246006410 sequence-specific DNA binding site [nucleotide binding]; other site 420246006411 Erythromycin esterase; Region: Erythro_esteras; cl17110 420246006412 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 420246006413 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 420246006414 putative active site [active] 420246006415 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 420246006416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 420246006417 Walker A/P-loop; other site 420246006418 ATP binding site [chemical binding]; other site 420246006419 Q-loop/lid; other site 420246006420 ABC transporter signature motif; other site 420246006421 Walker B; other site 420246006422 D-loop; other site 420246006423 H-loop/switch region; other site 420246006424 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 420246006425 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 420246006426 active site 420246006427 zinc binding site [ion binding]; other site 420246006428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 420246006429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246006430 active site 420246006431 phosphorylation site [posttranslational modification] 420246006432 intermolecular recognition site; other site 420246006433 dimerization interface [polypeptide binding]; other site 420246006434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 420246006435 DNA binding residues [nucleotide binding] 420246006436 dimerization interface [polypeptide binding]; other site 420246006437 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 420246006438 PDZ domain; Region: PDZ_2; pfam13180 420246006439 protein binding site [polypeptide binding]; other site 420246006440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 420246006441 Histidine kinase; Region: HisKA_3; pfam07730 420246006442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246006443 ATP binding site [chemical binding]; other site 420246006444 Mg2+ binding site [ion binding]; other site 420246006445 G-X-G motif; other site 420246006446 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 420246006447 substrate binding pocket [chemical binding]; other site 420246006448 substrate-Mg2+ binding site; other site 420246006449 aspartate-rich region 1; other site 420246006450 aspartate-rich region 2; other site 420246006451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246006452 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246006453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246006454 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 420246006455 active site 420246006456 DNA binding site [nucleotide binding] 420246006457 Int/Topo IB signature motif; other site 420246006458 DNA polymerase IV; Reviewed; Region: PRK03103 420246006459 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 420246006460 active site 420246006461 DNA binding site [nucleotide binding] 420246006462 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 420246006463 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246006464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246006465 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 420246006466 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 420246006467 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246006468 active site 420246006469 DNA binding site [nucleotide binding] 420246006470 Int/Topo IB signature motif; other site 420246006471 Transposase [DNA replication, recombination, and repair]; Region: COG5421 420246006472 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246006473 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246006474 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 420246006475 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 420246006476 active site 420246006477 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 420246006478 Helix-turn-helix domain; Region: HTH_36; pfam13730 420246006479 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 420246006480 active site 420246006481 catalytic residues [active] 420246006482 DNA binding site [nucleotide binding] 420246006483 Int/Topo IB signature motif; other site 420246006484 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 420246006485 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 420246006486 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 420246006487 putative dimer interface [polypeptide binding]; other site 420246006488 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 420246006489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246006490 DNA binding site [nucleotide binding] 420246006491 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 420246006492 putative dimerization interface [polypeptide binding]; other site 420246006493 putative ligand binding site [chemical binding]; other site 420246006494 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 420246006495 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 420246006496 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 420246006497 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 420246006498 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 420246006499 NAD binding site [chemical binding]; other site 420246006500 homodimer interface [polypeptide binding]; other site 420246006501 active site 420246006502 substrate binding site [chemical binding]; other site 420246006503 galactokinase; Provisional; Region: PRK05322 420246006504 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 420246006505 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 420246006506 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 420246006507 EcsC protein family; Region: EcsC; pfam12787 420246006508 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 420246006509 Melibiase; Region: Melibiase; pfam02065 420246006510 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 420246006511 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 420246006512 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 420246006513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246006514 dimerization interface [polypeptide binding]; other site 420246006515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246006516 dimer interface [polypeptide binding]; other site 420246006517 phosphorylation site [posttranslational modification] 420246006518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246006519 ATP binding site [chemical binding]; other site 420246006520 Mg2+ binding site [ion binding]; other site 420246006521 G-X-G motif; other site 420246006522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246006523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246006524 active site 420246006525 phosphorylation site [posttranslational modification] 420246006526 intermolecular recognition site; other site 420246006527 dimerization interface [polypeptide binding]; other site 420246006528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246006529 DNA binding site [nucleotide binding] 420246006530 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 420246006531 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 420246006532 putative dimer interface [polypeptide binding]; other site 420246006533 YppF-like protein; Region: YppF; pfam14178 420246006534 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 420246006535 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 420246006536 Transglycosylase; Region: Transgly; pfam00912 420246006537 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 420246006538 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 420246006539 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 420246006540 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 420246006541 minor groove reading motif; other site 420246006542 helix-hairpin-helix signature motif; other site 420246006543 substrate binding pocket [chemical binding]; other site 420246006544 active site 420246006545 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 420246006546 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 420246006547 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 420246006548 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 420246006549 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 420246006550 putative dimer interface [polypeptide binding]; other site 420246006551 putative anticodon binding site; other site 420246006552 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 420246006553 homodimer interface [polypeptide binding]; other site 420246006554 motif 1; other site 420246006555 motif 2; other site 420246006556 active site 420246006557 motif 3; other site 420246006558 aspartate aminotransferase; Provisional; Region: PRK05764 420246006559 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246006560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246006561 homodimer interface [polypeptide binding]; other site 420246006562 catalytic residue [active] 420246006563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 420246006564 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 420246006565 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 420246006566 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 420246006567 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 420246006568 active site 420246006569 catalytic site [active] 420246006570 substrate binding site [chemical binding]; other site 420246006571 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 420246006572 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 420246006573 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 420246006574 tetramerization interface [polypeptide binding]; other site 420246006575 active site 420246006576 pantoate--beta-alanine ligase; Region: panC; TIGR00018 420246006577 Pantoate-beta-alanine ligase; Region: PanC; cd00560 420246006578 active site 420246006579 ATP-binding site [chemical binding]; other site 420246006580 pantoate-binding site; other site 420246006581 HXXH motif; other site 420246006582 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 420246006583 oligomerization interface [polypeptide binding]; other site 420246006584 active site 420246006585 metal binding site [ion binding]; metal-binding site 420246006586 Biotin operon repressor [Transcription]; Region: BirA; COG1654 420246006587 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 420246006588 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 420246006589 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 420246006590 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 420246006591 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 420246006592 active site 420246006593 NTP binding site [chemical binding]; other site 420246006594 metal binding triad [ion binding]; metal-binding site 420246006595 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 420246006596 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 420246006597 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 420246006598 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 420246006599 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 420246006600 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 420246006601 active site 420246006602 dimer interfaces [polypeptide binding]; other site 420246006603 catalytic residues [active] 420246006604 dihydrodipicolinate reductase; Provisional; Region: PRK00048 420246006605 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 420246006606 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 420246006607 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 420246006608 homodimer interface [polypeptide binding]; other site 420246006609 metal binding site [ion binding]; metal-binding site 420246006610 Uncharacterized conserved protein [Function unknown]; Region: COG1284 420246006611 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246006612 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246006613 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 420246006614 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 420246006615 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 420246006616 intrachain domain interface; other site 420246006617 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 420246006618 Qi binding site; other site 420246006619 Qo binding site; other site 420246006620 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 420246006621 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 420246006622 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 420246006623 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 420246006624 interchain domain interface [polypeptide binding]; other site 420246006625 intrachain domain interface; other site 420246006626 heme bH binding site [chemical binding]; other site 420246006627 Qi binding site; other site 420246006628 heme bL binding site [chemical binding]; other site 420246006629 Qo binding site; other site 420246006630 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 420246006631 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 420246006632 iron-sulfur cluster [ion binding]; other site 420246006633 [2Fe-2S] cluster binding site [ion binding]; other site 420246006634 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 420246006635 hypothetical protein; Provisional; Region: PRK03636 420246006636 UPF0302 domain; Region: UPF0302; pfam08864 420246006637 IDEAL domain; Region: IDEAL; pfam08858 420246006638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246006639 binding surface 420246006640 TPR motif; other site 420246006641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 420246006642 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 420246006643 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 420246006644 hinge; other site 420246006645 active site 420246006646 prephenate dehydrogenase; Validated; Region: PRK06545 420246006647 prephenate dehydrogenase; Validated; Region: PRK08507 420246006648 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 420246006649 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 420246006650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246006651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246006652 homodimer interface [polypeptide binding]; other site 420246006653 catalytic residue [active] 420246006654 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 420246006655 substrate binding site [chemical binding]; other site 420246006656 active site 420246006657 catalytic residues [active] 420246006658 heterodimer interface [polypeptide binding]; other site 420246006659 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 420246006660 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 420246006661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246006662 catalytic residue [active] 420246006663 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 420246006664 active site 420246006665 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 420246006666 active site 420246006667 ribulose/triose binding site [chemical binding]; other site 420246006668 phosphate binding site [ion binding]; other site 420246006669 substrate (anthranilate) binding pocket [chemical binding]; other site 420246006670 product (indole) binding pocket [chemical binding]; other site 420246006671 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 420246006672 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 420246006673 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 420246006674 anthranilate synthase component I; Provisional; Region: PRK13569 420246006675 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 420246006676 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 420246006677 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 420246006678 homotrimer interaction site [polypeptide binding]; other site 420246006679 active site 420246006680 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 420246006681 active site 420246006682 dimer interface [polypeptide binding]; other site 420246006683 metal binding site [ion binding]; metal-binding site 420246006684 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 420246006685 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 420246006686 Tetramer interface [polypeptide binding]; other site 420246006687 active site 420246006688 FMN-binding site [chemical binding]; other site 420246006689 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 420246006690 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 420246006691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246006692 S-adenosylmethionine binding site [chemical binding]; other site 420246006693 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 420246006694 active site 420246006695 multimer interface [polypeptide binding]; other site 420246006696 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 420246006697 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 420246006698 substrate binding pocket [chemical binding]; other site 420246006699 chain length determination region; other site 420246006700 substrate-Mg2+ binding site; other site 420246006701 catalytic residues [active] 420246006702 aspartate-rich region 1; other site 420246006703 active site lid residues [active] 420246006704 aspartate-rich region 2; other site 420246006705 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 420246006706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246006707 S-adenosylmethionine binding site [chemical binding]; other site 420246006708 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 420246006709 transcription attenuation protein MtrB; Provisional; Region: PRK13251 420246006710 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 420246006711 homodecamer interface [polypeptide binding]; other site 420246006712 GTP cyclohydrolase I; Provisional; Region: PLN03044 420246006713 active site 420246006714 putative catalytic site residues [active] 420246006715 zinc binding site [ion binding]; other site 420246006716 GTP-CH-I/GFRP interaction surface; other site 420246006717 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 420246006718 IHF dimer interface [polypeptide binding]; other site 420246006719 IHF - DNA interface [nucleotide binding]; other site 420246006720 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 420246006721 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 420246006722 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 420246006723 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 420246006724 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 420246006725 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 420246006726 GTP-binding protein Der; Reviewed; Region: PRK00093 420246006727 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 420246006728 G1 box; other site 420246006729 GTP/Mg2+ binding site [chemical binding]; other site 420246006730 Switch I region; other site 420246006731 G2 box; other site 420246006732 Switch II region; other site 420246006733 G3 box; other site 420246006734 G4 box; other site 420246006735 G5 box; other site 420246006736 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 420246006737 G1 box; other site 420246006738 GTP/Mg2+ binding site [chemical binding]; other site 420246006739 Switch I region; other site 420246006740 G2 box; other site 420246006741 G3 box; other site 420246006742 Switch II region; other site 420246006743 G4 box; other site 420246006744 G5 box; other site 420246006745 YIEGIA protein; Region: YIEGIA; pfam14045 420246006746 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 420246006747 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 420246006748 RNA binding site [nucleotide binding]; other site 420246006749 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 420246006750 RNA binding site [nucleotide binding]; other site 420246006751 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 420246006752 RNA binding site [nucleotide binding]; other site 420246006753 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 420246006754 RNA binding site [nucleotide binding]; other site 420246006755 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 420246006756 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 420246006757 putative acyl-acceptor binding pocket; other site 420246006758 cytidylate kinase; Provisional; Region: cmk; PRK00023 420246006759 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 420246006760 CMP-binding site; other site 420246006761 The sites determining sugar specificity; other site 420246006762 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 420246006763 Flagellar protein YcgR; Region: YcgR_2; pfam12945 420246006764 PilZ domain; Region: PilZ; pfam07238 420246006765 germination protein YpeB; Region: spore_YpeB; TIGR02889 420246006766 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 420246006767 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246006768 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 420246006769 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 420246006770 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 420246006771 active site 420246006772 homotetramer interface [polypeptide binding]; other site 420246006773 homodimer interface [polypeptide binding]; other site 420246006774 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 420246006775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 420246006776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246006777 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 420246006778 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 420246006779 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 420246006780 NAD(P) binding site [chemical binding]; other site 420246006781 adaptor protein; Provisional; Region: PRK02899 420246006782 phosphodiesterase YaeI; Provisional; Region: PRK11340 420246006783 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 420246006784 putative active site [active] 420246006785 putative metal binding site [ion binding]; other site 420246006786 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 420246006787 CotJB protein; Region: CotJB; pfam12652 420246006788 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 420246006789 dimanganese center [ion binding]; other site 420246006790 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 420246006791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246006792 CAAX protease self-immunity; Region: Abi; pfam02517 420246006793 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 420246006794 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246006795 ATP binding site [chemical binding]; other site 420246006796 putative Mg++ binding site [ion binding]; other site 420246006797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246006798 nucleotide binding region [chemical binding]; other site 420246006799 ATP-binding site [chemical binding]; other site 420246006800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 420246006801 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 420246006802 dimer interface [polypeptide binding]; other site 420246006803 substrate binding site [chemical binding]; other site 420246006804 metal binding sites [ion binding]; metal-binding site 420246006805 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 420246006806 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 420246006807 ligand binding site [chemical binding]; other site 420246006808 NAD binding site [chemical binding]; other site 420246006809 dimerization interface [polypeptide binding]; other site 420246006810 catalytic site [active] 420246006811 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 420246006812 putative L-serine binding site [chemical binding]; other site 420246006813 histidinol-phosphatase; Provisional; Region: PRK07328 420246006814 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 420246006815 active site 420246006816 dimer interface [polypeptide binding]; other site 420246006817 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 420246006818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246006819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246006820 DNA binding residues [nucleotide binding] 420246006821 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 420246006822 dimerization interface [polypeptide binding]; other site 420246006823 ATP binding site [chemical binding]; other site 420246006824 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 420246006825 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 420246006826 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 420246006827 catalytic core [active] 420246006828 cobalamin synthase; Reviewed; Region: cobS; PRK00235 420246006829 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 420246006830 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 420246006831 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246006832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246006833 homodimer interface [polypeptide binding]; other site 420246006834 catalytic residue [active] 420246006835 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 420246006836 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 420246006837 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 420246006838 Walker A/P-loop; other site 420246006839 ATP binding site [chemical binding]; other site 420246006840 Q-loop/lid; other site 420246006841 ABC transporter signature motif; other site 420246006842 Walker B; other site 420246006843 D-loop; other site 420246006844 H-loop/switch region; other site 420246006845 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 420246006846 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 420246006847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246006848 dimer interface [polypeptide binding]; other site 420246006849 putative PBP binding regions; other site 420246006850 ABC-ATPase subunit interface; other site 420246006851 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 420246006852 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 420246006853 putative binding site residues; other site 420246006854 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 420246006855 pentamer interface [polypeptide binding]; other site 420246006856 dodecaamer interface [polypeptide binding]; other site 420246006857 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 420246006858 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 420246006859 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 420246006860 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 420246006861 active site turn [active] 420246006862 phosphorylation site [posttranslational modification] 420246006863 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 420246006864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246006865 DNA-binding site [nucleotide binding]; DNA binding site 420246006866 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 420246006867 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 420246006868 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 420246006869 active site 420246006870 trimer interface [polypeptide binding]; other site 420246006871 allosteric site; other site 420246006872 active site lid [active] 420246006873 hexamer (dimer of trimers) interface [polypeptide binding]; other site 420246006874 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 420246006875 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 420246006876 active site 420246006877 dimer interface [polypeptide binding]; other site 420246006878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 420246006879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246006880 dimerization interface [polypeptide binding]; other site 420246006881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246006882 dimer interface [polypeptide binding]; other site 420246006883 phosphorylation site [posttranslational modification] 420246006884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246006885 ATP binding site [chemical binding]; other site 420246006886 Mg2+ binding site [ion binding]; other site 420246006887 G-X-G motif; other site 420246006888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246006889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246006890 active site 420246006891 phosphorylation site [posttranslational modification] 420246006892 intermolecular recognition site; other site 420246006893 dimerization interface [polypeptide binding]; other site 420246006894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246006895 DNA binding site [nucleotide binding] 420246006896 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 420246006897 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 420246006898 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 420246006899 Double zinc ribbon; Region: DZR; pfam12773 420246006900 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 420246006901 ResB-like family; Region: ResB; pfam05140 420246006902 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 420246006903 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 420246006904 catalytic residues [active] 420246006905 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 420246006906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246006907 RNA binding surface [nucleotide binding]; other site 420246006908 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 420246006909 active site 420246006910 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 420246006911 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 420246006912 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 420246006913 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 420246006914 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 420246006915 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 420246006916 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 420246006917 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 420246006918 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 420246006919 Domain of unknown function (DUF309); Region: DUF309; pfam03745 420246006920 Hepatitis delta virus delta antigen; Region: HDV_ag; pfam01517 420246006921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246006922 Coenzyme A binding pocket [chemical binding]; other site 420246006923 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 420246006924 homopentamer interface [polypeptide binding]; other site 420246006925 active site 420246006926 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 420246006927 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 420246006928 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 420246006929 dimerization interface [polypeptide binding]; other site 420246006930 active site 420246006931 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 420246006932 Lumazine binding domain; Region: Lum_binding; pfam00677 420246006933 Lumazine binding domain; Region: Lum_binding; pfam00677 420246006934 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 420246006935 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 420246006936 catalytic motif [active] 420246006937 Zn binding site [ion binding]; other site 420246006938 RibD C-terminal domain; Region: RibD_C; cl17279 420246006939 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 420246006940 active site 420246006941 Predicted secreted protein [Function unknown]; Region: COG4086 420246006942 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 420246006943 diaminopimelate decarboxylase; Region: lysA; TIGR01048 420246006944 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 420246006945 active site 420246006946 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 420246006947 substrate binding site [chemical binding]; other site 420246006948 catalytic residues [active] 420246006949 dimer interface [polypeptide binding]; other site 420246006950 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 420246006951 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 420246006952 SpoVA protein; Region: SpoVA; pfam03862 420246006953 stage V sporulation protein AD; Validated; Region: PRK08304 420246006954 stage V sporulation protein AD; Provisional; Region: PRK12404 420246006955 SpoVA protein; Region: SpoVA; cl04298 420246006956 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 420246006957 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 420246006958 sporulation sigma factor SigF; Validated; Region: PRK05572 420246006959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246006960 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 420246006961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246006962 DNA binding residues [nucleotide binding] 420246006963 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 420246006964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246006965 ATP binding site [chemical binding]; other site 420246006966 Mg2+ binding site [ion binding]; other site 420246006967 G-X-G motif; other site 420246006968 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cd06844 420246006969 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 420246006970 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 420246006971 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 420246006972 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 420246006973 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 420246006974 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 420246006975 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 420246006976 purine nucleoside phosphorylase; Provisional; Region: PRK08202 420246006977 phosphopentomutase; Provisional; Region: PRK05362 420246006978 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 420246006979 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 420246006980 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 420246006981 active site 420246006982 Int/Topo IB signature motif; other site 420246006983 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 420246006984 ferric uptake regulator; Provisional; Region: fur; PRK09462 420246006985 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 420246006986 metal binding site 2 [ion binding]; metal-binding site 420246006987 putative DNA binding helix; other site 420246006988 metal binding site 1 [ion binding]; metal-binding site 420246006989 dimer interface [polypeptide binding]; other site 420246006990 structural Zn2+ binding site [ion binding]; other site 420246006991 stage II sporulation protein M; Region: spo_II_M; TIGR02831 420246006992 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 420246006993 PHP-associated; Region: PHP_C; pfam13263 420246006994 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 420246006995 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 420246006996 dimer interface [polypeptide binding]; other site 420246006997 ADP-ribose binding site [chemical binding]; other site 420246006998 active site 420246006999 nudix motif; other site 420246007000 metal binding site [ion binding]; metal-binding site 420246007001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 420246007002 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 420246007003 active site 420246007004 catalytic tetrad [active] 420246007005 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 420246007006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246007007 putative substrate translocation pore; other site 420246007008 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 420246007009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 420246007010 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 420246007011 YqzH-like protein; Region: YqzH; pfam14164 420246007012 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 420246007013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 420246007014 NAD(P) binding site [chemical binding]; other site 420246007015 active site 420246007016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246007017 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 420246007018 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 420246007019 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 420246007020 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 420246007021 active site 420246007022 FMN binding site [chemical binding]; other site 420246007023 substrate binding site [chemical binding]; other site 420246007024 homotetramer interface [polypeptide binding]; other site 420246007025 catalytic residue [active] 420246007026 ribonuclease Z; Region: RNase_Z; TIGR02651 420246007027 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 420246007028 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 420246007029 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 420246007030 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 420246007031 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 420246007032 beta-galactosidase; Region: BGL; TIGR03356 420246007033 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246007034 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 420246007035 NAD(P) binding site [chemical binding]; other site 420246007036 catalytic residues [active] 420246007037 homoserine dehydrogenase; Provisional; Region: PRK06270 420246007038 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 420246007039 NAD(P) binding pocket [chemical binding]; other site 420246007040 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 420246007041 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 420246007042 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 420246007043 metal binding site [ion binding]; metal-binding site 420246007044 dimer interface [polypeptide binding]; other site 420246007045 cystathionine gamma-synthase; Provisional; Region: PRK08249 420246007046 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 420246007047 homodimer interface [polypeptide binding]; other site 420246007048 substrate-cofactor binding pocket; other site 420246007049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007050 catalytic residue [active] 420246007051 ectoine utilization protein EutC; Validated; Region: PRK08291 420246007052 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 420246007053 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 420246007054 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 420246007055 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 420246007056 active site 420246007057 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 420246007058 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 420246007059 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 420246007060 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 420246007061 Aspartase; Region: Aspartase; cd01357 420246007062 active sites [active] 420246007063 tetramer interface [polypeptide binding]; other site 420246007064 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 420246007065 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 420246007066 tetramer interface [polypeptide binding]; other site 420246007067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007068 catalytic residue [active] 420246007069 proline/glycine betaine transporter; Provisional; Region: PRK10642 420246007070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246007071 putative substrate translocation pore; other site 420246007072 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 420246007073 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 420246007074 Walker A/P-loop; other site 420246007075 ATP binding site [chemical binding]; other site 420246007076 Q-loop/lid; other site 420246007077 ABC transporter signature motif; other site 420246007078 Walker B; other site 420246007079 D-loop; other site 420246007080 H-loop/switch region; other site 420246007081 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 420246007082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246007083 dimer interface [polypeptide binding]; other site 420246007084 conserved gate region; other site 420246007085 putative PBP binding loops; other site 420246007086 ABC-ATPase subunit interface; other site 420246007087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246007088 dimer interface [polypeptide binding]; other site 420246007089 conserved gate region; other site 420246007090 putative PBP binding loops; other site 420246007091 ABC-ATPase subunit interface; other site 420246007092 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 420246007093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 420246007094 substrate binding pocket [chemical binding]; other site 420246007095 membrane-bound complex binding site; other site 420246007096 hinge residues; other site 420246007097 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 420246007098 hydroxyglutarate oxidase; Provisional; Region: PRK11728 420246007099 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 420246007100 Ligand binding site [chemical binding]; other site 420246007101 Electron transfer flavoprotein domain; Region: ETF; pfam01012 420246007102 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 420246007103 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 420246007104 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 420246007105 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 420246007106 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 420246007107 metal binding site [ion binding]; metal-binding site 420246007108 dimer interface [polypeptide binding]; other site 420246007109 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 420246007110 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 420246007111 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 420246007112 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 420246007113 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 420246007114 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 420246007115 active site 420246007116 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 420246007117 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 420246007118 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 420246007119 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 420246007120 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 420246007121 peptidase T-like protein; Region: PepT-like; TIGR01883 420246007122 metal binding site [ion binding]; metal-binding site 420246007123 putative dimer interface [polypeptide binding]; other site 420246007124 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 420246007125 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 420246007126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 420246007127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 420246007128 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 420246007129 dimer interface [polypeptide binding]; other site 420246007130 substrate binding site [chemical binding]; other site 420246007131 metal binding site [ion binding]; metal-binding site 420246007132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 420246007133 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 420246007134 Predicted membrane protein [Function unknown]; Region: COG4129 420246007135 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 420246007136 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 420246007137 Disulphide isomerase; Region: Disulph_isomer; pfam06491 420246007138 membrane ATPase/protein kinase; Provisional; Region: PRK09435 420246007139 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 420246007140 Walker A; other site 420246007141 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 420246007142 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 420246007143 active site 420246007144 substrate binding site [chemical binding]; other site 420246007145 coenzyme B12 binding site [chemical binding]; other site 420246007146 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 420246007147 B12 binding site [chemical binding]; other site 420246007148 cobalt ligand [ion binding]; other site 420246007149 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 420246007150 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 420246007151 heterodimer interface [polypeptide binding]; other site 420246007152 substrate interaction site [chemical binding]; other site 420246007153 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 420246007154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246007155 dimerization interface [polypeptide binding]; other site 420246007156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246007157 dimer interface [polypeptide binding]; other site 420246007158 phosphorylation site [posttranslational modification] 420246007159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246007160 ATP binding site [chemical binding]; other site 420246007161 Mg2+ binding site [ion binding]; other site 420246007162 G-X-G motif; other site 420246007163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246007164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246007165 active site 420246007166 phosphorylation site [posttranslational modification] 420246007167 intermolecular recognition site; other site 420246007168 dimerization interface [polypeptide binding]; other site 420246007169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246007170 DNA binding site [nucleotide binding] 420246007171 PQQ-like domain; Region: PQQ_2; pfam13360 420246007172 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 420246007173 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 420246007174 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 420246007175 E3 interaction surface; other site 420246007176 lipoyl attachment site [posttranslational modification]; other site 420246007177 e3 binding domain; Region: E3_binding; pfam02817 420246007178 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 420246007179 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 420246007180 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 420246007181 alpha subunit interface [polypeptide binding]; other site 420246007182 TPP binding site [chemical binding]; other site 420246007183 heterodimer interface [polypeptide binding]; other site 420246007184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246007185 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 420246007186 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 420246007187 tetramer interface [polypeptide binding]; other site 420246007188 TPP-binding site [chemical binding]; other site 420246007189 heterodimer interface [polypeptide binding]; other site 420246007190 phosphorylation loop region [posttranslational modification] 420246007191 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 420246007192 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 420246007193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246007194 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 420246007195 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 420246007196 nucleotide binding site [chemical binding]; other site 420246007197 Acetokinase family; Region: Acetate_kinase; cl17229 420246007198 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 420246007199 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 420246007200 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 420246007201 NAD binding site [chemical binding]; other site 420246007202 Phe binding site; other site 420246007203 phosphate butyryltransferase; Validated; Region: PRK07742 420246007204 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 420246007205 NAD(P) binding site [chemical binding]; other site 420246007206 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 420246007207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246007208 putative active site [active] 420246007209 heme pocket [chemical binding]; other site 420246007210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246007211 putative active site [active] 420246007212 heme pocket [chemical binding]; other site 420246007213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246007214 Walker A motif; other site 420246007215 ATP binding site [chemical binding]; other site 420246007216 Walker B motif; other site 420246007217 arginine finger; other site 420246007218 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 420246007219 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 420246007220 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 420246007221 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 420246007222 active site 420246007223 catalytic site [active] 420246007224 metal binding site [ion binding]; metal-binding site 420246007225 dimer interface [polypeptide binding]; other site 420246007226 YycC-like protein; Region: YycC; pfam14174 420246007227 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 420246007228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246007229 active site 420246007230 phosphorylation site [posttranslational modification] 420246007231 intermolecular recognition site; other site 420246007232 dimerization interface [polypeptide binding]; other site 420246007233 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 420246007234 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 420246007235 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 420246007236 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 420246007237 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 420246007238 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 420246007239 Walker A/P-loop; other site 420246007240 ATP binding site [chemical binding]; other site 420246007241 Q-loop/lid; other site 420246007242 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 420246007243 ABC transporter signature motif; other site 420246007244 Walker B; other site 420246007245 D-loop; other site 420246007246 H-loop/switch region; other site 420246007247 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 420246007248 arginine repressor; Provisional; Region: PRK04280 420246007249 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 420246007250 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 420246007251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246007252 RNA binding surface [nucleotide binding]; other site 420246007253 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 420246007254 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 420246007255 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 420246007256 TPP-binding site; other site 420246007257 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 420246007258 PYR/PP interface [polypeptide binding]; other site 420246007259 dimer interface [polypeptide binding]; other site 420246007260 TPP binding site [chemical binding]; other site 420246007261 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246007262 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 420246007263 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 420246007264 substrate binding pocket [chemical binding]; other site 420246007265 chain length determination region; other site 420246007266 substrate-Mg2+ binding site; other site 420246007267 catalytic residues [active] 420246007268 aspartate-rich region 1; other site 420246007269 active site lid residues [active] 420246007270 aspartate-rich region 2; other site 420246007271 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 420246007272 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 420246007273 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 420246007274 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 420246007275 homodimer interface [polypeptide binding]; other site 420246007276 NADP binding site [chemical binding]; other site 420246007277 substrate binding site [chemical binding]; other site 420246007278 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 420246007279 putative RNA binding site [nucleotide binding]; other site 420246007280 Asp23 family; Region: Asp23; pfam03780 420246007281 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 420246007282 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 420246007283 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 420246007284 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 420246007285 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 420246007286 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 420246007287 carboxyltransferase (CT) interaction site; other site 420246007288 biotinylation site [posttranslational modification]; other site 420246007289 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 420246007290 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 420246007291 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 420246007292 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 420246007293 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 420246007294 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 420246007295 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 420246007296 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 420246007297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246007298 Walker A motif; other site 420246007299 ATP binding site [chemical binding]; other site 420246007300 Walker B motif; other site 420246007301 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 420246007302 elongation factor P; Validated; Region: PRK00529 420246007303 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 420246007304 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 420246007305 RNA binding site [nucleotide binding]; other site 420246007306 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 420246007307 RNA binding site [nucleotide binding]; other site 420246007308 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 420246007309 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 420246007310 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 420246007311 active site 420246007312 Conserved membrane protein YqhR; Region: YqhR; pfam11085 420246007313 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 420246007314 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 420246007315 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 420246007316 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 420246007317 active site 420246007318 nucleophile elbow; other site 420246007319 manganese transport transcriptional regulator; Provisional; Region: PRK03902 420246007320 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 420246007321 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 420246007322 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 420246007323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246007324 FeS/SAM binding site; other site 420246007325 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 420246007326 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 420246007327 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 420246007328 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246007329 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 420246007330 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 420246007331 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246007332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246007333 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 420246007334 active site 420246007335 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 420246007336 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 420246007337 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 420246007338 active site residue [active] 420246007339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 420246007340 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 420246007341 non-specific DNA interactions [nucleotide binding]; other site 420246007342 DNA binding site [nucleotide binding] 420246007343 sequence specific DNA binding site [nucleotide binding]; other site 420246007344 putative cAMP binding site [chemical binding]; other site 420246007345 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 420246007346 ROK family; Region: ROK; pfam00480 420246007347 nucleotide binding site [chemical binding]; other site 420246007348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 420246007349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 420246007350 active site 420246007351 catalytic tetrad [active] 420246007352 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 420246007353 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 420246007354 tetramer interface [polypeptide binding]; other site 420246007355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007356 catalytic residue [active] 420246007357 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 420246007358 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 420246007359 tetramer interface [polypeptide binding]; other site 420246007360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007361 catalytic residue [active] 420246007362 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 420246007363 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 420246007364 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 420246007365 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 420246007366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246007367 ATP binding site [chemical binding]; other site 420246007368 putative Mg++ binding site [ion binding]; other site 420246007369 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 420246007370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246007371 nucleotide binding region [chemical binding]; other site 420246007372 ATP-binding site [chemical binding]; other site 420246007373 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 420246007374 YqzE-like protein; Region: YqzE; pfam14038 420246007375 ComG operon protein 7; Region: ComGG; pfam14173 420246007376 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 420246007377 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 420246007378 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 420246007379 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 420246007380 Type II/IV secretion system protein; Region: T2SE; pfam00437 420246007381 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 420246007382 Walker A motif; other site 420246007383 ATP binding site [chemical binding]; other site 420246007384 Walker B motif; other site 420246007385 Predicted transcriptional regulator [Transcription]; Region: COG2345 420246007386 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246007387 putative DNA binding site [nucleotide binding]; other site 420246007388 putative Zn2+ binding site [ion binding]; other site 420246007389 V4R domain; Region: V4R; cl15268 420246007390 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 420246007391 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 420246007392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246007393 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 420246007394 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 420246007395 putative active site [active] 420246007396 Zn binding site [ion binding]; other site 420246007397 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 420246007398 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 420246007399 nucleotide binding site [chemical binding]; other site 420246007400 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 420246007401 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 420246007402 Rhomboid family; Region: Rhomboid; pfam01694 420246007403 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 420246007404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246007405 motif II; other site 420246007406 Integral membrane protein DUF92; Region: DUF92; pfam01940 420246007407 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 420246007408 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 420246007409 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 420246007410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 420246007411 YceG-like family; Region: YceG; pfam02618 420246007412 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 420246007413 PhoU domain; Region: PhoU; pfam01895 420246007414 PhoU domain; Region: PhoU; pfam01895 420246007415 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 420246007416 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 420246007417 Walker A/P-loop; other site 420246007418 ATP binding site [chemical binding]; other site 420246007419 Q-loop/lid; other site 420246007420 ABC transporter signature motif; other site 420246007421 Walker B; other site 420246007422 D-loop; other site 420246007423 H-loop/switch region; other site 420246007424 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 420246007425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246007426 dimer interface [polypeptide binding]; other site 420246007427 conserved gate region; other site 420246007428 putative PBP binding loops; other site 420246007429 ABC-ATPase subunit interface; other site 420246007430 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 420246007431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246007432 dimer interface [polypeptide binding]; other site 420246007433 conserved gate region; other site 420246007434 putative PBP binding loops; other site 420246007435 ABC-ATPase subunit interface; other site 420246007436 PBP superfamily domain; Region: PBP_like_2; cl17296 420246007437 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 420246007438 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 420246007439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 420246007440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246007441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246007442 putative substrate translocation pore; other site 420246007443 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 420246007444 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 420246007445 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 420246007446 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 420246007447 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246007448 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 420246007449 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 420246007450 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 420246007451 Uncharacterized conserved protein [Function unknown]; Region: COG5663 420246007452 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 420246007453 metal binding site 2 [ion binding]; metal-binding site 420246007454 putative DNA binding helix; other site 420246007455 metal binding site 1 [ion binding]; metal-binding site 420246007456 dimer interface [polypeptide binding]; other site 420246007457 structural Zn2+ binding site [ion binding]; other site 420246007458 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 420246007459 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 420246007460 ABC-ATPase subunit interface; other site 420246007461 dimer interface [polypeptide binding]; other site 420246007462 putative PBP binding regions; other site 420246007463 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 420246007464 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 420246007465 Uncharacterized conserved protein [Function unknown]; Region: COG1284 420246007466 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246007467 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246007468 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 420246007469 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 420246007470 endonuclease IV; Provisional; Region: PRK01060 420246007471 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 420246007472 AP (apurinic/apyrimidinic) site pocket; other site 420246007473 DNA interaction; other site 420246007474 Metal-binding active site; metal-binding site 420246007475 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 420246007476 DEAD-like helicases superfamily; Region: DEXDc; smart00487 420246007477 ATP binding site [chemical binding]; other site 420246007478 Mg++ binding site [ion binding]; other site 420246007479 motif III; other site 420246007480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246007481 nucleotide binding region [chemical binding]; other site 420246007482 ATP-binding site [chemical binding]; other site 420246007483 YqfQ-like protein; Region: YqfQ; pfam14181 420246007484 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 420246007485 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 420246007486 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 420246007487 Uncharacterized conserved protein [Function unknown]; Region: COG0327 420246007488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 420246007489 Uncharacterized conserved protein [Function unknown]; Region: COG0327 420246007490 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 420246007491 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 420246007492 Family of unknown function (DUF633); Region: DUF633; pfam04816 420246007493 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 420246007494 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 420246007495 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 420246007496 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 420246007497 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 420246007498 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 420246007499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246007500 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 420246007501 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246007502 DNA binding residues [nucleotide binding] 420246007503 DNA primase; Validated; Region: dnaG; PRK05667 420246007504 CHC2 zinc finger; Region: zf-CHC2; pfam01807 420246007505 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 420246007506 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 420246007507 active site 420246007508 metal binding site [ion binding]; metal-binding site 420246007509 interdomain interaction site; other site 420246007510 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 420246007511 PEP synthetase regulatory protein; Provisional; Region: PRK05339 420246007512 HTH domain; Region: HTH_11; pfam08279 420246007513 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 420246007514 FOG: CBS domain [General function prediction only]; Region: COG0517 420246007515 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 420246007516 Recombination protein O N terminal; Region: RecO_N; pfam11967 420246007517 Recombination protein O C terminal; Region: RecO_C; pfam02565 420246007518 YqzL-like protein; Region: YqzL; pfam14006 420246007519 GTPase Era; Reviewed; Region: era; PRK00089 420246007520 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 420246007521 G1 box; other site 420246007522 GTP/Mg2+ binding site [chemical binding]; other site 420246007523 Switch I region; other site 420246007524 G2 box; other site 420246007525 Switch II region; other site 420246007526 G3 box; other site 420246007527 G4 box; other site 420246007528 G5 box; other site 420246007529 KH domain; Region: KH_2; pfam07650 420246007530 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 420246007531 active site 420246007532 catalytic motif [active] 420246007533 Zn binding site [ion binding]; other site 420246007534 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 420246007535 metal-binding heat shock protein; Provisional; Region: PRK00016 420246007536 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 420246007537 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 420246007538 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246007539 Zn2+ binding site [ion binding]; other site 420246007540 Mg2+ binding site [ion binding]; other site 420246007541 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 420246007542 PhoH-like protein; Region: PhoH; pfam02562 420246007543 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 420246007544 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 420246007545 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 420246007546 Yqey-like protein; Region: YqeY; pfam09424 420246007547 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 420246007548 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 420246007549 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 420246007550 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 420246007551 intersubunit interface [polypeptide binding]; other site 420246007552 active site 420246007553 catalytic residue [active] 420246007554 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 420246007555 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 420246007556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246007557 FeS/SAM binding site; other site 420246007558 TRAM domain; Region: TRAM; pfam01938 420246007559 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 420246007560 RNA methyltransferase, RsmE family; Region: TIGR00046 420246007561 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 420246007562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246007563 S-adenosylmethionine binding site [chemical binding]; other site 420246007564 chaperone protein DnaJ; Provisional; Region: PRK14280 420246007565 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 420246007566 HSP70 interaction site [polypeptide binding]; other site 420246007567 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 420246007568 substrate binding site [polypeptide binding]; other site 420246007569 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 420246007570 Zn binding sites [ion binding]; other site 420246007571 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 420246007572 dimer interface [polypeptide binding]; other site 420246007573 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 420246007574 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 420246007575 nucleotide binding site [chemical binding]; other site 420246007576 NEF interaction site [polypeptide binding]; other site 420246007577 SBD interface [polypeptide binding]; other site 420246007578 heat shock protein GrpE; Provisional; Region: PRK14140 420246007579 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 420246007580 dimer interface [polypeptide binding]; other site 420246007581 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 420246007582 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 420246007583 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 420246007584 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246007585 FeS/SAM binding site; other site 420246007586 HemN C-terminal domain; Region: HemN_C; pfam06969 420246007587 GTP-binding protein LepA; Provisional; Region: PRK05433 420246007588 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 420246007589 G1 box; other site 420246007590 putative GEF interaction site [polypeptide binding]; other site 420246007591 GTP/Mg2+ binding site [chemical binding]; other site 420246007592 Switch I region; other site 420246007593 G2 box; other site 420246007594 G3 box; other site 420246007595 Switch II region; other site 420246007596 G4 box; other site 420246007597 G5 box; other site 420246007598 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 420246007599 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 420246007600 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 420246007601 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 420246007602 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 420246007603 stage II sporulation protein P; Region: spore_II_P; TIGR02867 420246007604 germination protease; Provisional; Region: PRK02858 420246007605 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 420246007606 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 420246007607 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 420246007608 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 420246007609 YqzM-like protein; Region: YqzM; pfam14141 420246007610 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 420246007611 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 420246007612 Competence protein; Region: Competence; pfam03772 420246007613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 420246007614 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 420246007615 catalytic motif [active] 420246007616 Zn binding site [ion binding]; other site 420246007617 SLBB domain; Region: SLBB; pfam10531 420246007618 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 420246007619 late competence protein ComER; Validated; Region: PRK07680 420246007620 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 420246007621 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 420246007622 N2227-like protein; Region: N2227; pfam07942 420246007623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246007624 S-adenosylmethionine binding site [chemical binding]; other site 420246007625 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 420246007626 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246007627 Zn2+ binding site [ion binding]; other site 420246007628 Mg2+ binding site [ion binding]; other site 420246007629 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 420246007630 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 420246007631 active site 420246007632 (T/H)XGH motif; other site 420246007633 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 420246007634 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 420246007635 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 420246007636 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 420246007637 shikimate binding site; other site 420246007638 NAD(P) binding site [chemical binding]; other site 420246007639 GTPase YqeH; Provisional; Region: PRK13796 420246007640 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 420246007641 GTP/Mg2+ binding site [chemical binding]; other site 420246007642 G4 box; other site 420246007643 G5 box; other site 420246007644 G1 box; other site 420246007645 Switch I region; other site 420246007646 G2 box; other site 420246007647 G3 box; other site 420246007648 Switch II region; other site 420246007649 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 420246007650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246007651 active site 420246007652 motif I; other site 420246007653 motif II; other site 420246007654 Sporulation inhibitor A; Region: Sda; pfam08970 420246007655 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 420246007656 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 420246007657 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 420246007658 flagellar motor protein MotA; Validated; Region: PRK08124 420246007659 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 420246007660 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 420246007661 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 420246007662 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 420246007663 ligand binding site [chemical binding]; other site 420246007664 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 420246007665 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 420246007666 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 420246007667 sporulation sigma factor SigK; Reviewed; Region: PRK05803 420246007668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246007669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246007670 DNA binding residues [nucleotide binding] 420246007671 YrhC-like protein; Region: YrhC; pfam14143 420246007672 cystathionine beta-lyase; Provisional; Region: PRK07671 420246007673 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 420246007674 homodimer interface [polypeptide binding]; other site 420246007675 substrate-cofactor binding pocket; other site 420246007676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007677 catalytic residue [active] 420246007678 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 420246007679 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 420246007680 dimer interface [polypeptide binding]; other site 420246007681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007682 catalytic residue [active] 420246007683 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 420246007684 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 420246007685 Methyltransferase domain; Region: Methyltransf_23; pfam13489 420246007686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246007687 S-adenosylmethionine binding site [chemical binding]; other site 420246007688 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 420246007689 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 420246007690 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 420246007691 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 420246007692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 420246007693 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 420246007694 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 420246007695 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 420246007696 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 420246007697 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 420246007698 Sugar specificity; other site 420246007699 Pyrimidine base specificity; other site 420246007700 ATP-binding site [chemical binding]; other site 420246007701 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 420246007702 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 420246007703 Peptidase family U32; Region: Peptidase_U32; pfam01136 420246007704 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 420246007705 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 420246007706 Peptidase family U32; Region: Peptidase_U32; pfam01136 420246007707 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 420246007708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 420246007709 S-adenosylmethionine binding site [chemical binding]; other site 420246007710 YceG-like family; Region: YceG; pfam02618 420246007711 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 420246007712 dimerization interface [polypeptide binding]; other site 420246007713 hypothetical protein; Provisional; Region: PRK13678 420246007714 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 420246007715 hypothetical protein; Provisional; Region: PRK05473 420246007716 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 420246007717 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 420246007718 motif 1; other site 420246007719 active site 420246007720 motif 2; other site 420246007721 motif 3; other site 420246007722 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 420246007723 DHHA1 domain; Region: DHHA1; pfam02272 420246007724 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 420246007725 Domain of unknown function DUF20; Region: UPF0118; pfam01594 420246007726 PRC-barrel domain; Region: PRC; pfam05239 420246007727 PRC-barrel domain; Region: PRC; pfam05239 420246007728 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 420246007729 AAA domain; Region: AAA_30; pfam13604 420246007730 Family description; Region: UvrD_C_2; pfam13538 420246007731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246007732 binding surface 420246007733 TPR motif; other site 420246007734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246007735 binding surface 420246007736 TPR motif; other site 420246007737 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 420246007738 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 420246007739 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 420246007740 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 420246007741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246007742 catalytic residue [active] 420246007743 Predicted transcriptional regulator [Transcription]; Region: COG1959 420246007744 Transcriptional regulator; Region: Rrf2; pfam02082 420246007745 Predicted membrane protein [Function unknown]; Region: COG2364 420246007746 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246007747 recombination factor protein RarA; Reviewed; Region: PRK13342 420246007748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246007749 Walker A motif; other site 420246007750 ATP binding site [chemical binding]; other site 420246007751 Walker B motif; other site 420246007752 arginine finger; other site 420246007753 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 420246007754 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 420246007755 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 420246007756 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 420246007757 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 420246007758 putative ATP binding site [chemical binding]; other site 420246007759 putative substrate interface [chemical binding]; other site 420246007760 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 420246007761 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 420246007762 homodimer interface [polypeptide binding]; other site 420246007763 motif 1; other site 420246007764 active site 420246007765 motif 2; other site 420246007766 GAD domain; Region: GAD; pfam02938 420246007767 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 420246007768 motif 3; other site 420246007769 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 420246007770 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 420246007771 dimer interface [polypeptide binding]; other site 420246007772 motif 1; other site 420246007773 active site 420246007774 motif 2; other site 420246007775 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 420246007776 anticodon binding site; other site 420246007777 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 420246007778 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 420246007779 catalytic residue [active] 420246007780 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 420246007781 catalytic residues [active] 420246007782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246007783 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246007784 peroxiredoxin; Region: AhpC; TIGR03137 420246007785 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 420246007786 dimer interface [polypeptide binding]; other site 420246007787 decamer (pentamer of dimers) interface [polypeptide binding]; other site 420246007788 catalytic triad [active] 420246007789 peroxidatic and resolving cysteines [active] 420246007790 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 420246007791 putative active site [active] 420246007792 dimerization interface [polypeptide binding]; other site 420246007793 putative tRNAtyr binding site [nucleotide binding]; other site 420246007794 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 420246007795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246007796 Zn2+ binding site [ion binding]; other site 420246007797 Mg2+ binding site [ion binding]; other site 420246007798 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 420246007799 synthetase active site [active] 420246007800 NTP binding site [chemical binding]; other site 420246007801 metal binding site [ion binding]; metal-binding site 420246007802 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 420246007803 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 420246007804 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246007805 active site 420246007806 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 420246007807 DHH family; Region: DHH; pfam01368 420246007808 DHHA1 domain; Region: DHHA1; pfam02272 420246007809 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 420246007810 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 420246007811 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 420246007812 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 420246007813 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 420246007814 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 420246007815 Protein export membrane protein; Region: SecD_SecF; pfam02355 420246007816 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 420246007817 stage V sporulation protein B; Region: spore_V_B; TIGR02900 420246007818 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 420246007819 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 420246007820 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 420246007821 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 420246007822 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 420246007823 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 420246007824 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 420246007825 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 420246007826 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 420246007827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246007828 Walker A motif; other site 420246007829 ATP binding site [chemical binding]; other site 420246007830 Walker B motif; other site 420246007831 arginine finger; other site 420246007832 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 420246007833 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 420246007834 RuvA N terminal domain; Region: RuvA_N; pfam01330 420246007835 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 420246007836 BofC C-terminal domain; Region: BofC_C; pfam08955 420246007837 hypothetical protein; Validated; Region: PRK00110 420246007838 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 420246007839 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 420246007840 NAD synthetase; Provisional; Region: PRK13980 420246007841 homodimer interface [polypeptide binding]; other site 420246007842 NAD binding pocket [chemical binding]; other site 420246007843 ATP binding pocket [chemical binding]; other site 420246007844 Mg binding site [ion binding]; other site 420246007845 active-site loop [active] 420246007846 Phosphotransferase enzyme family; Region: APH; pfam01636 420246007847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 420246007848 quinolinate synthetase; Provisional; Region: PRK09375 420246007849 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 420246007850 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 420246007851 dimerization interface [polypeptide binding]; other site 420246007852 active site 420246007853 L-aspartate oxidase; Provisional; Region: PRK08071 420246007854 L-aspartate oxidase; Provisional; Region: PRK06175 420246007855 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 420246007856 cysteine desulfurase; Provisional; Region: PRK02948 420246007857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246007858 catalytic residue [active] 420246007859 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 420246007860 HTH domain; Region: HTH_11; pfam08279 420246007861 3H domain; Region: 3H; pfam02829 420246007862 prephenate dehydratase; Provisional; Region: PRK11898 420246007863 Prephenate dehydratase; Region: PDT; pfam00800 420246007864 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 420246007865 putative L-Phe binding site [chemical binding]; other site 420246007866 hypothetical protein; Provisional; Region: PRK04435 420246007867 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 420246007868 GTPase CgtA; Reviewed; Region: obgE; PRK12297 420246007869 GTP1/OBG; Region: GTP1_OBG; pfam01018 420246007870 Obg GTPase; Region: Obg; cd01898 420246007871 G1 box; other site 420246007872 GTP/Mg2+ binding site [chemical binding]; other site 420246007873 Switch I region; other site 420246007874 G2 box; other site 420246007875 G3 box; other site 420246007876 Switch II region; other site 420246007877 G4 box; other site 420246007878 G5 box; other site 420246007879 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 420246007880 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 420246007881 hypothetical protein; Provisional; Region: PRK14553 420246007882 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 420246007883 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 420246007884 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 420246007885 Peptidase family M50; Region: Peptidase_M50; pfam02163 420246007886 active site 420246007887 putative substrate binding region [chemical binding]; other site 420246007888 Peptidase family M23; Region: Peptidase_M23; pfam01551 420246007889 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 420246007890 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 420246007891 Switch I; other site 420246007892 Switch II; other site 420246007893 septum formation inhibitor; Reviewed; Region: minC; PRK00513 420246007894 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 420246007895 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 420246007896 rod shape-determining protein MreC; Provisional; Region: PRK13922 420246007897 rod shape-determining protein MreC; Region: MreC; pfam04085 420246007898 rod shape-determining protein MreB; Provisional; Region: PRK13927 420246007899 MreB and similar proteins; Region: MreB_like; cd10225 420246007900 nucleotide binding site [chemical binding]; other site 420246007901 Mg binding site [ion binding]; other site 420246007902 putative protofilament interaction site [polypeptide binding]; other site 420246007903 RodZ interaction site [polypeptide binding]; other site 420246007904 hypothetical protein; Reviewed; Region: PRK00024 420246007905 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 420246007906 helix-hairpin-helix signature motif; other site 420246007907 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 420246007908 MPN+ (JAMM) motif; other site 420246007909 Zinc-binding site [ion binding]; other site 420246007910 Maf-like protein; Region: Maf; pfam02545 420246007911 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 420246007912 active site 420246007913 dimer interface [polypeptide binding]; other site 420246007914 Pilus assembly protein, PilO; Region: PilO; cl01234 420246007915 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 420246007916 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 420246007917 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 420246007918 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 420246007919 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 420246007920 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 420246007921 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 420246007922 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 420246007923 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 420246007924 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 420246007925 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 420246007926 Walker A motif; other site 420246007927 ATP binding site [chemical binding]; other site 420246007928 Walker B motif; other site 420246007929 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 420246007930 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 420246007931 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 420246007932 Walker A motif; other site 420246007933 ATP binding site [chemical binding]; other site 420246007934 Walker B motif; other site 420246007935 VanW like protein; Region: VanW; pfam04294 420246007936 G5 domain; Region: G5; pfam07501 420246007937 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 420246007938 metal ion-dependent adhesion site (MIDAS); other site 420246007939 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 420246007940 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 420246007941 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 420246007942 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 420246007943 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 420246007944 active site 420246007945 HIGH motif; other site 420246007946 nucleotide binding site [chemical binding]; other site 420246007947 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 420246007948 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 420246007949 active site 420246007950 KMSKS motif; other site 420246007951 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 420246007952 tRNA binding surface [nucleotide binding]; other site 420246007953 anticodon binding site; other site 420246007954 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 420246007955 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 420246007956 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 420246007957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246007958 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 420246007959 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 420246007960 inhibitor-cofactor binding pocket; inhibition site 420246007961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246007962 catalytic residue [active] 420246007963 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 420246007964 dimer interface [polypeptide binding]; other site 420246007965 active site 420246007966 Schiff base residues; other site 420246007967 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 420246007968 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 420246007969 active site 420246007970 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 420246007971 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 420246007972 domain interfaces; other site 420246007973 active site 420246007974 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 420246007975 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 420246007976 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 420246007977 tRNA; other site 420246007978 putative tRNA binding site [nucleotide binding]; other site 420246007979 putative NADP binding site [chemical binding]; other site 420246007980 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 420246007981 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 420246007982 G1 box; other site 420246007983 GTP/Mg2+ binding site [chemical binding]; other site 420246007984 Switch I region; other site 420246007985 G2 box; other site 420246007986 G3 box; other site 420246007987 Switch II region; other site 420246007988 G4 box; other site 420246007989 G5 box; other site 420246007990 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 420246007991 Found in ATP-dependent protease La (LON); Region: LON; smart00464 420246007992 Found in ATP-dependent protease La (LON); Region: LON; smart00464 420246007993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246007994 Walker A motif; other site 420246007995 ATP binding site [chemical binding]; other site 420246007996 Walker B motif; other site 420246007997 arginine finger; other site 420246007998 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 420246007999 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 420246008000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246008001 Walker A motif; other site 420246008002 ATP binding site [chemical binding]; other site 420246008003 Walker B motif; other site 420246008004 arginine finger; other site 420246008005 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 420246008006 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 420246008007 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 420246008008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246008009 Walker A motif; other site 420246008010 ATP binding site [chemical binding]; other site 420246008011 Walker B motif; other site 420246008012 arginine finger; other site 420246008013 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 420246008014 trigger factor; Provisional; Region: tig; PRK01490 420246008015 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 420246008016 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 420246008017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246008018 binding surface 420246008019 Tetratricopeptide repeat; Region: TPR_16; pfam13432 420246008020 TPR motif; other site 420246008021 Tetratricopeptide repeat; Region: TPR_16; pfam13432 420246008022 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 420246008023 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 420246008024 substrate binding site [chemical binding]; other site 420246008025 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 420246008026 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 420246008027 substrate binding site [chemical binding]; other site 420246008028 ligand binding site [chemical binding]; other site 420246008029 tartrate dehydrogenase; Region: TTC; TIGR02089 420246008030 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 420246008031 2-isopropylmalate synthase; Validated; Region: PRK00915 420246008032 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 420246008033 active site 420246008034 catalytic residues [active] 420246008035 metal binding site [ion binding]; metal-binding site 420246008036 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 420246008037 ketol-acid reductoisomerase; Provisional; Region: PRK05479 420246008038 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 420246008039 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 420246008040 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 420246008041 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 420246008042 putative valine binding site [chemical binding]; other site 420246008043 dimer interface [polypeptide binding]; other site 420246008044 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 420246008045 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 420246008046 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 420246008047 PYR/PP interface [polypeptide binding]; other site 420246008048 dimer interface [polypeptide binding]; other site 420246008049 TPP binding site [chemical binding]; other site 420246008050 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 420246008051 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 420246008052 TPP-binding site [chemical binding]; other site 420246008053 dimer interface [polypeptide binding]; other site 420246008054 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 420246008055 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 420246008056 homodimer interface [polypeptide binding]; other site 420246008057 substrate-cofactor binding pocket; other site 420246008058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246008059 catalytic residue [active] 420246008060 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 420246008061 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 420246008062 active site 420246008063 metal binding site [ion binding]; metal-binding site 420246008064 homotetramer interface [polypeptide binding]; other site 420246008065 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 420246008066 active site 420246008067 dimerization interface [polypeptide binding]; other site 420246008068 ribonuclease PH; Reviewed; Region: rph; PRK00173 420246008069 Ribonuclease PH; Region: RNase_PH_bact; cd11362 420246008070 hexamer interface [polypeptide binding]; other site 420246008071 active site 420246008072 Spore germination protein [General function prediction only]; Region: COG5401 420246008073 Sporulation and spore germination; Region: Germane; pfam10646 420246008074 Sporulation and spore germination; Region: Germane; pfam10646 420246008075 glutamate racemase; Provisional; Region: PRK00865 420246008076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 420246008077 MarR family; Region: MarR; pfam01047 420246008078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 420246008079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 420246008080 DNA binding residues [nucleotide binding] 420246008081 dimerization interface [polypeptide binding]; other site 420246008082 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 420246008083 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 420246008084 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 420246008085 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 420246008086 L-aspartate oxidase; Provisional; Region: PRK06175 420246008087 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 420246008088 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 420246008089 putative Iron-sulfur protein interface [polypeptide binding]; other site 420246008090 proximal heme binding site [chemical binding]; other site 420246008091 distal heme binding site [chemical binding]; other site 420246008092 putative dimer interface [polypeptide binding]; other site 420246008093 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 420246008094 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 420246008095 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 420246008096 GIY-YIG motif/motif A; other site 420246008097 active site 420246008098 catalytic site [active] 420246008099 putative DNA binding site [nucleotide binding]; other site 420246008100 metal binding site [ion binding]; metal-binding site 420246008101 UvrB/uvrC motif; Region: UVR; pfam02151 420246008102 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 420246008103 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 420246008104 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 420246008105 active site 420246008106 dimer interface [polypeptide binding]; other site 420246008107 non-prolyl cis peptide bond; other site 420246008108 insertion regions; other site 420246008109 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 420246008110 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 420246008111 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 420246008112 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 420246008113 substrate binding pocket [chemical binding]; other site 420246008114 membrane-bound complex binding site; other site 420246008115 hinge residues; other site 420246008116 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 420246008117 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 420246008118 Walker A/P-loop; other site 420246008119 ATP binding site [chemical binding]; other site 420246008120 Q-loop/lid; other site 420246008121 ABC transporter signature motif; other site 420246008122 Walker B; other site 420246008123 D-loop; other site 420246008124 H-loop/switch region; other site 420246008125 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 420246008126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246008127 dimer interface [polypeptide binding]; other site 420246008128 conserved gate region; other site 420246008129 putative PBP binding loops; other site 420246008130 ABC-ATPase subunit interface; other site 420246008131 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 420246008132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 420246008133 substrate binding pocket [chemical binding]; other site 420246008134 membrane-bound complex binding site; other site 420246008135 hinge residues; other site 420246008136 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 420246008137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 420246008138 catalytic residues [active] 420246008139 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 420246008140 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 420246008141 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 420246008142 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 420246008143 Ligand binding site [chemical binding]; other site 420246008144 Electron transfer flavoprotein domain; Region: ETF; pfam01012 420246008145 enoyl-CoA hydratase; Provisional; Region: PRK07658 420246008146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246008147 substrate binding site [chemical binding]; other site 420246008148 oxyanion hole (OAH) forming residues; other site 420246008149 trimer interface [polypeptide binding]; other site 420246008150 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 420246008151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246008152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246008153 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 420246008154 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 420246008155 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 420246008156 acyl-activating enzyme (AAE) consensus motif; other site 420246008157 putative AMP binding site [chemical binding]; other site 420246008158 putative active site [active] 420246008159 putative CoA binding site [chemical binding]; other site 420246008160 Predicted membrane protein [Function unknown]; Region: COG3766 420246008161 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 420246008162 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 420246008163 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 420246008164 MutS domain III; Region: MutS_III; pfam05192 420246008165 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 420246008166 Walker A/P-loop; other site 420246008167 ATP binding site [chemical binding]; other site 420246008168 Q-loop/lid; other site 420246008169 ABC transporter signature motif; other site 420246008170 Walker B; other site 420246008171 D-loop; other site 420246008172 H-loop/switch region; other site 420246008173 Smr domain; Region: Smr; pfam01713 420246008174 hypothetical protein; Provisional; Region: PRK08609 420246008175 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 420246008176 active site 420246008177 primer binding site [nucleotide binding]; other site 420246008178 NTP binding site [chemical binding]; other site 420246008179 metal binding triad [ion binding]; metal-binding site 420246008180 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 420246008181 active site 420246008182 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 420246008183 Colicin V production protein; Region: Colicin_V; pfam02674 420246008184 cell division protein ZapA; Provisional; Region: PRK14126 420246008185 ribonuclease HIII; Provisional; Region: PRK00996 420246008186 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 420246008187 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 420246008188 RNA/DNA hybrid binding site [nucleotide binding]; other site 420246008189 active site 420246008190 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 420246008191 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 420246008192 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 420246008193 MarR family; Region: MarR_2; pfam12802 420246008194 Alkaline phosphatase homologues; Region: alkPPc; smart00098 420246008195 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 420246008196 active site 420246008197 dimer interface [polypeptide binding]; other site 420246008198 camphor resistance protein CrcB; Provisional; Region: PRK14205 420246008199 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 420246008200 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 420246008201 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 420246008202 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 420246008203 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 420246008204 putative tRNA-binding site [nucleotide binding]; other site 420246008205 B3/4 domain; Region: B3_4; pfam03483 420246008206 tRNA synthetase B5 domain; Region: B5; smart00874 420246008207 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 420246008208 dimer interface [polypeptide binding]; other site 420246008209 motif 1; other site 420246008210 motif 3; other site 420246008211 motif 2; other site 420246008212 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 420246008213 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 420246008214 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 420246008215 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 420246008216 dimer interface [polypeptide binding]; other site 420246008217 motif 1; other site 420246008218 active site 420246008219 motif 2; other site 420246008220 motif 3; other site 420246008221 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 420246008222 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 420246008223 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 420246008224 methionine sulfoxide reductase A; Provisional; Region: PRK14054 420246008225 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 420246008226 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 420246008227 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 420246008228 oligomer interface [polypeptide binding]; other site 420246008229 active site 420246008230 metal binding site [ion binding]; metal-binding site 420246008231 dUTPase; Region: dUTPase_2; pfam08761 420246008232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 420246008233 active site 420246008234 homodimer interface [polypeptide binding]; other site 420246008235 metal binding site [ion binding]; metal-binding site 420246008236 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 420246008237 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 420246008238 23S rRNA binding site [nucleotide binding]; other site 420246008239 L21 binding site [polypeptide binding]; other site 420246008240 L13 binding site [polypeptide binding]; other site 420246008241 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 420246008242 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 420246008243 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 420246008244 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 420246008245 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 420246008246 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 420246008247 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 420246008248 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 420246008249 active site 420246008250 dimer interface [polypeptide binding]; other site 420246008251 motif 1; other site 420246008252 motif 2; other site 420246008253 motif 3; other site 420246008254 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 420246008255 anticodon binding site; other site 420246008256 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 420246008257 primosomal protein DnaI; Reviewed; Region: PRK08939 420246008258 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 420246008259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246008260 Walker A motif; other site 420246008261 ATP binding site [chemical binding]; other site 420246008262 Walker B motif; other site 420246008263 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 420246008264 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 420246008265 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 420246008266 ATP cone domain; Region: ATP-cone; pfam03477 420246008267 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 420246008268 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 420246008269 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 420246008270 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 420246008271 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 420246008272 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 420246008273 CoA-binding site [chemical binding]; other site 420246008274 ATP-binding [chemical binding]; other site 420246008275 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 420246008276 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 420246008277 DNA binding site [nucleotide binding] 420246008278 catalytic residue [active] 420246008279 H2TH interface [polypeptide binding]; other site 420246008280 putative catalytic residues [active] 420246008281 turnover-facilitating residue; other site 420246008282 intercalation triad [nucleotide binding]; other site 420246008283 8OG recognition residue [nucleotide binding]; other site 420246008284 putative reading head residues; other site 420246008285 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 420246008286 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 420246008287 DNA polymerase I; Provisional; Region: PRK05755 420246008288 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 420246008289 active site 420246008290 metal binding site 1 [ion binding]; metal-binding site 420246008291 putative 5' ssDNA interaction site; other site 420246008292 metal binding site 3; metal-binding site 420246008293 metal binding site 2 [ion binding]; metal-binding site 420246008294 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 420246008295 putative DNA binding site [nucleotide binding]; other site 420246008296 putative metal binding site [ion binding]; other site 420246008297 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 420246008298 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 420246008299 active site 420246008300 DNA binding site [nucleotide binding] 420246008301 catalytic site [active] 420246008302 HAMP domain; Region: HAMP; pfam00672 420246008303 dimerization interface [polypeptide binding]; other site 420246008304 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 420246008305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246008306 putative active site [active] 420246008307 heme pocket [chemical binding]; other site 420246008308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246008309 dimer interface [polypeptide binding]; other site 420246008310 phosphorylation site [posttranslational modification] 420246008311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246008312 ATP binding site [chemical binding]; other site 420246008313 G-X-G motif; other site 420246008314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246008315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246008316 active site 420246008317 phosphorylation site [posttranslational modification] 420246008318 intermolecular recognition site; other site 420246008319 dimerization interface [polypeptide binding]; other site 420246008320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246008321 DNA binding site [nucleotide binding] 420246008322 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 420246008323 active site 2 [active] 420246008324 active site 1 [active] 420246008325 malate dehydrogenase; Reviewed; Region: PRK06223 420246008326 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 420246008327 NAD(P) binding site [chemical binding]; other site 420246008328 dimer interface [polypeptide binding]; other site 420246008329 tetramer (dimer of dimers) interface [polypeptide binding]; other site 420246008330 substrate binding site [chemical binding]; other site 420246008331 isocitrate dehydrogenase; Reviewed; Region: PRK07006 420246008332 isocitrate dehydrogenase; Validated; Region: PRK06451 420246008333 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 420246008334 dimer interface [polypeptide binding]; other site 420246008335 Citrate synthase; Region: Citrate_synt; pfam00285 420246008336 active site 420246008337 citrylCoA binding site [chemical binding]; other site 420246008338 oxalacetate/citrate binding site [chemical binding]; other site 420246008339 coenzyme A binding site [chemical binding]; other site 420246008340 catalytic triad [active] 420246008341 Protein of unknown function (DUF441); Region: DUF441; pfam04284 420246008342 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 420246008343 Domain of unknown function DUF20; Region: UPF0118; pfam01594 420246008344 pyruvate kinase; Provisional; Region: PRK06354 420246008345 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 420246008346 domain interfaces; other site 420246008347 active site 420246008348 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 420246008349 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 420246008350 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 420246008351 active site 420246008352 ADP/pyrophosphate binding site [chemical binding]; other site 420246008353 dimerization interface [polypeptide binding]; other site 420246008354 allosteric effector site; other site 420246008355 fructose-1,6-bisphosphate binding site; other site 420246008356 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 420246008357 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 420246008358 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 420246008359 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 420246008360 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 420246008361 Transcriptional regulators [Transcription]; Region: FadR; COG2186 420246008362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246008363 DNA-binding site [nucleotide binding]; DNA binding site 420246008364 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 420246008365 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 420246008366 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 420246008367 active site 420246008368 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 420246008369 generic binding surface II; other site 420246008370 generic binding surface I; other site 420246008371 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 420246008372 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 420246008373 DHH family; Region: DHH; pfam01368 420246008374 DHHA1 domain; Region: DHHA1; pfam02272 420246008375 YtpI-like protein; Region: YtpI; pfam14007 420246008376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 420246008377 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 420246008378 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246008379 DNA-binding site [nucleotide binding]; DNA binding site 420246008380 DRTGG domain; Region: DRTGG; pfam07085 420246008381 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 420246008382 Thioesterase superfamily; Region: 4HBT; pfam03061 420246008383 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 420246008384 metal-dependent hydrolase; Provisional; Region: PRK00685 420246008385 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 420246008386 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 420246008387 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 420246008388 active site 420246008389 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 420246008390 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 420246008391 hexamer interface [polypeptide binding]; other site 420246008392 ligand binding site [chemical binding]; other site 420246008393 putative active site [active] 420246008394 NAD(P) binding site [chemical binding]; other site 420246008395 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 420246008396 classical (c) SDRs; Region: SDR_c; cd05233 420246008397 NAD(P) binding site [chemical binding]; other site 420246008398 active site 420246008399 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 420246008400 Ligand Binding Site [chemical binding]; other site 420246008401 argininosuccinate lyase; Provisional; Region: PRK00855 420246008402 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 420246008403 active sites [active] 420246008404 tetramer interface [polypeptide binding]; other site 420246008405 argininosuccinate synthase; Provisional; Region: PRK13820 420246008406 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 420246008407 ANP binding site [chemical binding]; other site 420246008408 Substrate Binding Site II [chemical binding]; other site 420246008409 Substrate Binding Site I [chemical binding]; other site 420246008410 acetyl-CoA synthetase; Provisional; Region: PRK04319 420246008411 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 420246008412 active site 420246008413 acyl-activating enzyme (AAE) consensus motif; other site 420246008414 putative CoA binding site [chemical binding]; other site 420246008415 AMP binding site [chemical binding]; other site 420246008416 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 420246008417 MPT binding site; other site 420246008418 trimer interface [polypeptide binding]; other site 420246008419 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 420246008420 propionate/acetate kinase; Provisional; Region: PRK12379 420246008421 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 420246008422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246008423 S-adenosylmethionine binding site [chemical binding]; other site 420246008424 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 420246008425 dimer interface [polypeptide binding]; other site 420246008426 catalytic triad [active] 420246008427 peroxidatic and resolving cysteines [active] 420246008428 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 420246008429 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 420246008430 RDD family; Region: RDD; pfam06271 420246008431 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 420246008432 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 420246008433 tandem repeat interface [polypeptide binding]; other site 420246008434 oligomer interface [polypeptide binding]; other site 420246008435 active site residues [active] 420246008436 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 420246008437 ATP-NAD kinase; Region: NAD_kinase; pfam01513 420246008438 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 420246008439 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 420246008440 active site 420246008441 acyl-activating enzyme (AAE) consensus motif; other site 420246008442 putative CoA binding site [chemical binding]; other site 420246008443 AMP binding site [chemical binding]; other site 420246008444 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 420246008445 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 420246008446 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 420246008447 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 420246008448 Ligand Binding Site [chemical binding]; other site 420246008449 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 420246008450 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 420246008451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246008452 catalytic residue [active] 420246008453 septation ring formation regulator EzrA; Provisional; Region: PRK04778 420246008454 histidinol-phosphatase; Reviewed; Region: PRK08123 420246008455 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 420246008456 active site 420246008457 dimer interface [polypeptide binding]; other site 420246008458 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 420246008459 GAF domain; Region: GAF_2; pfam13185 420246008460 GAF domain; Region: GAF; cl17456 420246008461 GAF domain; Region: GAF_2; pfam13185 420246008462 GAF domain; Region: GAF_3; pfam13492 420246008463 GAF domain; Region: GAF_2; pfam13185 420246008464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246008465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246008466 metal binding site [ion binding]; metal-binding site 420246008467 active site 420246008468 I-site; other site 420246008469 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 420246008470 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 420246008471 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246008472 RNA binding surface [nucleotide binding]; other site 420246008473 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 420246008474 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 420246008475 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 420246008476 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 420246008477 Na binding site [ion binding]; other site 420246008478 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 420246008479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246008480 PAS domain; Region: PAS_9; pfam13426 420246008481 putative active site [active] 420246008482 heme pocket [chemical binding]; other site 420246008483 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 420246008484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246008485 Walker A motif; other site 420246008486 ATP binding site [chemical binding]; other site 420246008487 Walker B motif; other site 420246008488 arginine finger; other site 420246008489 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 420246008490 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 420246008491 active site 420246008492 HIGH motif; other site 420246008493 dimer interface [polypeptide binding]; other site 420246008494 KMSKS motif; other site 420246008495 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 420246008496 RNA binding surface [nucleotide binding]; other site 420246008497 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 420246008498 Transglycosylase; Region: Transgly; pfam00912 420246008499 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 420246008500 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 420246008501 Interdomain contacts; other site 420246008502 Cytokine receptor motif; other site 420246008503 acetyl-CoA synthetase; Provisional; Region: PRK04319 420246008504 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 420246008505 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 420246008506 active site 420246008507 acyl-activating enzyme (AAE) consensus motif; other site 420246008508 putative CoA binding site [chemical binding]; other site 420246008509 AMP binding site [chemical binding]; other site 420246008510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246008511 FOG: CBS domain [General function prediction only]; Region: COG0517 420246008512 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 420246008513 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 420246008514 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 420246008515 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 420246008516 active site 420246008517 Zn binding site [ion binding]; other site 420246008518 catabolite control protein A; Region: ccpA; TIGR01481 420246008519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246008520 DNA binding site [nucleotide binding] 420246008521 domain linker motif; other site 420246008522 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 420246008523 dimerization interface [polypeptide binding]; other site 420246008524 effector binding site; other site 420246008525 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 420246008526 Chorismate mutase type II; Region: CM_2; cl00693 420246008527 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 420246008528 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 420246008529 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 420246008530 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 420246008531 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 420246008532 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 420246008533 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 420246008534 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 420246008535 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 420246008536 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 420246008537 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 420246008538 putative tRNA-binding site [nucleotide binding]; other site 420246008539 hypothetical protein; Provisional; Region: PRK13668 420246008540 NTPase; Reviewed; Region: PRK03114 420246008541 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 420246008542 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 420246008543 oligomer interface [polypeptide binding]; other site 420246008544 active site 420246008545 metal binding site [ion binding]; metal-binding site 420246008546 Predicted small secreted protein [Function unknown]; Region: COG5584 420246008547 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 420246008548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246008549 S-adenosylmethionine binding site [chemical binding]; other site 420246008550 YtzH-like protein; Region: YtzH; pfam14165 420246008551 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 420246008552 Phosphotransferase enzyme family; Region: APH; pfam01636 420246008553 active site 420246008554 ATP binding site [chemical binding]; other site 420246008555 substrate binding site [chemical binding]; other site 420246008556 pullulanase, type I; Region: pulA_typeI; TIGR02104 420246008557 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 420246008558 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 420246008559 Ca binding site [ion binding]; other site 420246008560 active site 420246008561 catalytic site [active] 420246008562 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 420246008563 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 420246008564 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 420246008565 sugar efflux transporter; Region: 2A0120; TIGR00899 420246008566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246008567 putative substrate translocation pore; other site 420246008568 dipeptidase PepV; Reviewed; Region: PRK07318 420246008569 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 420246008570 active site 420246008571 metal binding site [ion binding]; metal-binding site 420246008572 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 420246008573 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 420246008574 active site 420246008575 uracil binding [chemical binding]; other site 420246008576 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 420246008577 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 420246008578 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 420246008579 HI0933-like protein; Region: HI0933_like; pfam03486 420246008580 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 420246008581 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 420246008582 active site residue [active] 420246008583 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 420246008584 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 420246008585 HIGH motif; other site 420246008586 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 420246008587 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 420246008588 active site 420246008589 KMSKS motif; other site 420246008590 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 420246008591 tRNA binding surface [nucleotide binding]; other site 420246008592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246008593 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246008594 putative substrate translocation pore; other site 420246008595 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 420246008596 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 420246008597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246008598 S-adenosylmethionine binding site [chemical binding]; other site 420246008599 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 420246008600 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 420246008601 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 420246008602 trimer interface [polypeptide binding]; other site 420246008603 putative metal binding site [ion binding]; other site 420246008604 S-adenosylmethionine synthetase; Validated; Region: PRK05250 420246008605 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 420246008606 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 420246008607 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 420246008608 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 420246008609 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 420246008610 active site 420246008611 substrate-binding site [chemical binding]; other site 420246008612 metal-binding site [ion binding] 420246008613 ATP binding site [chemical binding]; other site 420246008614 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 420246008615 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 420246008616 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 420246008617 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 420246008618 NMT1-like family; Region: NMT1_2; pfam13379 420246008619 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 420246008620 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 420246008621 Walker A/P-loop; other site 420246008622 ATP binding site [chemical binding]; other site 420246008623 Q-loop/lid; other site 420246008624 ABC transporter signature motif; other site 420246008625 Walker B; other site 420246008626 D-loop; other site 420246008627 H-loop/switch region; other site 420246008628 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 420246008629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246008630 dimer interface [polypeptide binding]; other site 420246008631 conserved gate region; other site 420246008632 putative PBP binding loops; other site 420246008633 ABC-ATPase subunit interface; other site 420246008634 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 420246008635 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 420246008636 nudix motif; other site 420246008637 Holin family; Region: Phage_holin_4; pfam05105 420246008638 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 420246008639 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 420246008640 dimerization interface [polypeptide binding]; other site 420246008641 DPS ferroxidase diiron center [ion binding]; other site 420246008642 ion pore; other site 420246008643 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 420246008644 S-ribosylhomocysteinase; Provisional; Region: PRK02260 420246008645 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 420246008646 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 420246008647 metal binding site [ion binding]; metal-binding site 420246008648 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 420246008649 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 420246008650 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 420246008651 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 420246008652 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 420246008653 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 420246008654 acyl-activating enzyme (AAE) consensus motif; other site 420246008655 putative AMP binding site [chemical binding]; other site 420246008656 putative active site [active] 420246008657 putative CoA binding site [chemical binding]; other site 420246008658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246008659 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 420246008660 substrate binding site [chemical binding]; other site 420246008661 oxyanion hole (OAH) forming residues; other site 420246008662 trimer interface [polypeptide binding]; other site 420246008663 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 420246008664 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 420246008665 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 420246008666 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 420246008667 dimer interface [polypeptide binding]; other site 420246008668 tetramer interface [polypeptide binding]; other site 420246008669 PYR/PP interface [polypeptide binding]; other site 420246008670 TPP binding site [chemical binding]; other site 420246008671 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 420246008672 TPP-binding site; other site 420246008673 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 420246008674 isochorismate synthases; Region: isochor_syn; TIGR00543 420246008675 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 420246008676 UbiA prenyltransferase family; Region: UbiA; pfam01040 420246008677 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 420246008678 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 420246008679 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 420246008680 homodimer interface [polypeptide binding]; other site 420246008681 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 420246008682 active site pocket [active] 420246008683 glycogen synthase; Provisional; Region: glgA; PRK00654 420246008684 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 420246008685 ADP-binding pocket [chemical binding]; other site 420246008686 homodimer interface [polypeptide binding]; other site 420246008687 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 420246008688 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 420246008689 ligand binding site; other site 420246008690 oligomer interface; other site 420246008691 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 420246008692 dimer interface [polypeptide binding]; other site 420246008693 N-terminal domain interface [polypeptide binding]; other site 420246008694 sulfate 1 binding site; other site 420246008695 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 420246008696 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 420246008697 ligand binding site; other site 420246008698 oligomer interface; other site 420246008699 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 420246008700 dimer interface [polypeptide binding]; other site 420246008701 N-terminal domain interface [polypeptide binding]; other site 420246008702 sulfate 1 binding site; other site 420246008703 glycogen branching enzyme; Provisional; Region: PRK12313 420246008704 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 420246008705 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 420246008706 active site 420246008707 catalytic site [active] 420246008708 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 420246008709 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 420246008710 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 420246008711 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 420246008712 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 420246008713 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 420246008714 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 420246008715 LytTr DNA-binding domain; Region: LytTR; smart00850 420246008716 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 420246008717 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 420246008718 putative acetyltransferase YhhY; Provisional; Region: PRK10140 420246008719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246008720 Coenzyme A binding pocket [chemical binding]; other site 420246008721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246008722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246008723 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246008724 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 420246008725 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 420246008726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 420246008727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246008728 Coenzyme A binding pocket [chemical binding]; other site 420246008729 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 420246008730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246008731 Coenzyme A binding pocket [chemical binding]; other site 420246008732 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 420246008733 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 420246008734 homodimer interaction site [polypeptide binding]; other site 420246008735 cofactor binding site; other site 420246008736 DinB family; Region: DinB; cl17821 420246008737 DinB superfamily; Region: DinB_2; pfam12867 420246008738 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 420246008739 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 420246008740 active site 420246008741 metal binding site [ion binding]; metal-binding site 420246008742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246008743 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 420246008744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 420246008745 Coenzyme A binding pocket [chemical binding]; other site 420246008746 Predicted helicase [General function prediction only]; Region: COG4889 420246008747 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 420246008748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246008749 ATP binding site [chemical binding]; other site 420246008750 putative Mg++ binding site [ion binding]; other site 420246008751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246008752 nucleotide binding region [chemical binding]; other site 420246008753 ATP-binding site [chemical binding]; other site 420246008754 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 420246008755 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 420246008756 active site 420246008757 metal binding site [ion binding]; metal-binding site 420246008758 Sporulation related domain; Region: SPOR; pfam05036 420246008759 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 420246008760 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 420246008761 active site 420246008762 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 420246008763 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 420246008764 Phage-related protein [Function unknown]; Region: COG4722 420246008765 Phage tail protein; Region: Sipho_tail; pfam05709 420246008766 Phage-related protein [Function unknown]; Region: COG5412 420246008767 membrane protein P6; Region: PHA01399 420246008768 Phage-related minor tail protein [Function unknown]; Region: COG5280 420246008769 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 420246008770 Phage capsid family; Region: Phage_capsid; pfam05065 420246008771 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 420246008772 Phage-related protein [Function unknown]; Region: COG4695; cl01923 420246008773 Phage portal protein; Region: Phage_portal; pfam04860 420246008774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 420246008775 Terminase-like family; Region: Terminase_6; pfam03237 420246008776 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 420246008777 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 420246008778 positive control sigma-like factor; Validated; Region: PRK06930 420246008779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246008780 Uncharacterized conserved protein [Function unknown]; Region: COG5484 420246008781 SEC-C motif; Region: SEC-C; pfam02810 420246008782 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 420246008783 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 420246008784 Response regulator receiver domain; Region: Response_reg; pfam00072 420246008785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246008786 active site 420246008787 phosphorylation site [posttranslational modification] 420246008788 intermolecular recognition site; other site 420246008789 dimerization interface [polypeptide binding]; other site 420246008790 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 420246008791 Transposase; Region: HTH_Tnp_1; cl17663 420246008792 dUTPase; Region: dUTPase_2; pfam08761 420246008793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 420246008794 active site 420246008795 homodimer interface [polypeptide binding]; other site 420246008796 metal binding site [ion binding]; metal-binding site 420246008797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 420246008798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 420246008799 dimer interface [polypeptide binding]; other site 420246008800 ssDNA binding site [nucleotide binding]; other site 420246008801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 420246008802 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 420246008803 active site 420246008804 replicative DNA helicase; Region: DnaB; TIGR00665 420246008805 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 420246008806 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 420246008807 Walker A motif; other site 420246008808 ATP binding site [chemical binding]; other site 420246008809 Walker B motif; other site 420246008810 DNA binding loops [nucleotide binding] 420246008811 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 420246008812 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 420246008813 ERF superfamily; Region: ERF; pfam04404 420246008814 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 420246008815 Domain of unknown function (DUF771); Region: DUF771; cl09962 420246008816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 420246008817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246008818 non-specific DNA binding site [nucleotide binding]; other site 420246008819 salt bridge; other site 420246008820 sequence-specific DNA binding site [nucleotide binding]; other site 420246008821 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 420246008822 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 420246008823 Int/Topo IB signature motif; other site 420246008824 transglutaminase; Provisional; Region: tgl; PRK03187 420246008825 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 420246008826 EamA-like transporter family; Region: EamA; pfam00892 420246008827 EamA-like transporter family; Region: EamA; pfam00892 420246008828 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 420246008829 MgtC family; Region: MgtC; pfam02308 420246008830 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 420246008831 Staphylococcal nuclease homologues; Region: SNc; smart00318 420246008832 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 420246008833 Catalytic site; other site 420246008834 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 420246008835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246008836 Coenzyme A binding pocket [chemical binding]; other site 420246008837 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 420246008838 Protein export membrane protein; Region: SecD_SecF; cl14618 420246008839 Small acid-soluble spore protein H family; Region: SspH; pfam08141 420246008840 Ion channel; Region: Ion_trans_2; pfam07885 420246008841 TrkA-N domain; Region: TrkA_N; pfam02254 420246008842 YugN-like family; Region: YugN; pfam08868 420246008843 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 420246008844 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 420246008845 active site 420246008846 dimer interface [polypeptide binding]; other site 420246008847 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 420246008848 dimer interface [polypeptide binding]; other site 420246008849 active site 420246008850 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 420246008851 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 420246008852 dimer interface [polypeptide binding]; other site 420246008853 active site 420246008854 metal binding site [ion binding]; metal-binding site 420246008855 Domain of unknown function (DUF378); Region: DUF378; pfam04070 420246008856 general stress protein 13; Validated; Region: PRK08059 420246008857 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 420246008858 RNA binding site [nucleotide binding]; other site 420246008859 hypothetical protein; Validated; Region: PRK07682 420246008860 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246008861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246008862 homodimer interface [polypeptide binding]; other site 420246008863 catalytic residue [active] 420246008864 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 420246008865 AsnC family; Region: AsnC_trans_reg; pfam01037 420246008866 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 420246008867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 420246008868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246008869 homodimer interface [polypeptide binding]; other site 420246008870 catalytic residue [active] 420246008871 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 420246008872 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 420246008873 E-class dimer interface [polypeptide binding]; other site 420246008874 P-class dimer interface [polypeptide binding]; other site 420246008875 active site 420246008876 Cu2+ binding site [ion binding]; other site 420246008877 Zn2+ binding site [ion binding]; other site 420246008878 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 420246008879 active site 420246008880 catalytic site [active] 420246008881 substrate binding site [chemical binding]; other site 420246008882 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 420246008883 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 420246008884 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 420246008885 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 420246008886 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 420246008887 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 420246008888 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 420246008889 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 420246008890 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 420246008891 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 420246008892 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 420246008893 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 420246008894 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 420246008895 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 420246008896 multifunctional aminopeptidase A; Provisional; Region: PRK00913 420246008897 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 420246008898 interface (dimer of trimers) [polypeptide binding]; other site 420246008899 Substrate-binding/catalytic site; other site 420246008900 Zn-binding sites [ion binding]; other site 420246008901 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 420246008902 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 420246008903 cobalamin binding residues [chemical binding]; other site 420246008904 putative BtuC binding residues; other site 420246008905 dimer interface [polypeptide binding]; other site 420246008906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 420246008907 Putative membrane protein; Region: YuiB; pfam14068 420246008908 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 420246008909 nudix motif; other site 420246008910 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 420246008911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246008912 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 420246008913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246008914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246008915 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 420246008916 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 420246008917 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 420246008918 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 420246008919 hypothetical protein; Provisional; Region: PRK13669 420246008920 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 420246008921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246008922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246008923 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 420246008924 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 420246008925 homoserine kinase; Provisional; Region: PRK01212 420246008926 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 420246008927 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 420246008928 threonine synthase; Reviewed; Region: PRK06721 420246008929 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 420246008930 homodimer interface [polypeptide binding]; other site 420246008931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 420246008932 catalytic residue [active] 420246008933 homoserine dehydrogenase; Provisional; Region: PRK06349 420246008934 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 420246008935 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 420246008936 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 420246008937 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 420246008938 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 420246008939 dimerization interface [polypeptide binding]; other site 420246008940 ligand binding site [chemical binding]; other site 420246008941 NADP binding site [chemical binding]; other site 420246008942 catalytic site [active] 420246008943 spore coat protein YutH; Region: spore_yutH; TIGR02905 420246008944 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 420246008945 tetramer interfaces [polypeptide binding]; other site 420246008946 binuclear metal-binding site [ion binding]; other site 420246008947 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 420246008948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246008949 active site 420246008950 motif I; other site 420246008951 motif II; other site 420246008952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246008953 Uncharacterized conserved protein [Function unknown]; Region: COG2445 420246008954 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 420246008955 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 420246008956 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 420246008957 lipoyl synthase; Provisional; Region: PRK05481 420246008958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246008959 FeS/SAM binding site; other site 420246008960 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 420246008961 Peptidase family M23; Region: Peptidase_M23; pfam01551 420246008962 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 420246008963 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 420246008964 Walker A/P-loop; other site 420246008965 ATP binding site [chemical binding]; other site 420246008966 Q-loop/lid; other site 420246008967 ABC transporter signature motif; other site 420246008968 Walker B; other site 420246008969 D-loop; other site 420246008970 H-loop/switch region; other site 420246008971 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 420246008972 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 420246008973 Walker A/P-loop; other site 420246008974 ATP binding site [chemical binding]; other site 420246008975 Q-loop/lid; other site 420246008976 ABC transporter signature motif; other site 420246008977 Walker B; other site 420246008978 D-loop; other site 420246008979 H-loop/switch region; other site 420246008980 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 420246008981 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 420246008982 TM-ABC transporter signature motif; other site 420246008983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246008984 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 420246008985 TM-ABC transporter signature motif; other site 420246008986 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 420246008987 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 420246008988 putative ligand binding site [chemical binding]; other site 420246008989 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 420246008990 Uncharacterized conserved protein [Function unknown]; Region: COG3377 420246008991 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 420246008992 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 420246008993 active site 420246008994 metal binding site [ion binding]; metal-binding site 420246008995 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 420246008996 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 420246008997 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 420246008998 Uncharacterized conserved protein [Function unknown]; Region: COG1801 420246008999 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 420246009000 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 420246009001 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 420246009002 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 420246009003 FeS assembly protein SufB; Region: sufB; TIGR01980 420246009004 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 420246009005 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 420246009006 trimerization site [polypeptide binding]; other site 420246009007 active site 420246009008 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 420246009009 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 420246009010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246009011 catalytic residue [active] 420246009012 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 420246009013 FeS assembly protein SufD; Region: sufD; TIGR01981 420246009014 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 420246009015 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 420246009016 Walker A/P-loop; other site 420246009017 ATP binding site [chemical binding]; other site 420246009018 Q-loop/lid; other site 420246009019 ABC transporter signature motif; other site 420246009020 Walker B; other site 420246009021 D-loop; other site 420246009022 H-loop/switch region; other site 420246009023 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 420246009024 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 420246009025 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 420246009026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009027 ABC-ATPase subunit interface; other site 420246009028 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 420246009029 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 420246009030 Walker A/P-loop; other site 420246009031 ATP binding site [chemical binding]; other site 420246009032 Q-loop/lid; other site 420246009033 ABC transporter signature motif; other site 420246009034 Walker B; other site 420246009035 D-loop; other site 420246009036 H-loop/switch region; other site 420246009037 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 420246009038 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 420246009039 catalytic residues [active] 420246009040 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 420246009041 putative active site [active] 420246009042 putative metal binding site [ion binding]; other site 420246009043 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 420246009044 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 420246009045 lipoyl attachment site [posttranslational modification]; other site 420246009046 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 420246009047 ArsC family; Region: ArsC; pfam03960 420246009048 putative ArsC-like catalytic residues; other site 420246009049 putative TRX-like catalytic residues [active] 420246009050 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 420246009051 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246009052 active site 420246009053 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 420246009054 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 420246009055 dimer interface [polypeptide binding]; other site 420246009056 active site 420246009057 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 420246009058 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 420246009059 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 420246009060 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 420246009061 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 420246009062 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 420246009063 substrate binding site [chemical binding]; other site 420246009064 oxyanion hole (OAH) forming residues; other site 420246009065 trimer interface [polypeptide binding]; other site 420246009066 YuzL-like protein; Region: YuzL; pfam14115 420246009067 Proline dehydrogenase; Region: Pro_dh; cl03282 420246009068 Coat F domain; Region: Coat_F; pfam07875 420246009069 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 420246009070 Spore germination protein; Region: Spore_permease; cl17796 420246009071 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 420246009072 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 420246009073 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 420246009074 pyruvate kinase; Provisional; Region: PRK14725 420246009075 domain interfaces; other site 420246009076 active site 420246009077 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 420246009078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246009079 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 420246009080 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 420246009081 DctM-like transporters; Region: DctM; pfam06808 420246009082 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 420246009083 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 420246009084 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 420246009085 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246009086 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246009087 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 420246009088 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 420246009089 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 420246009090 Walker A/P-loop; other site 420246009091 ATP binding site [chemical binding]; other site 420246009092 Q-loop/lid; other site 420246009093 ABC transporter signature motif; other site 420246009094 Walker B; other site 420246009095 D-loop; other site 420246009096 H-loop/switch region; other site 420246009097 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 420246009098 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 420246009099 Walker A/P-loop; other site 420246009100 ATP binding site [chemical binding]; other site 420246009101 Q-loop/lid; other site 420246009102 ABC transporter signature motif; other site 420246009103 Walker B; other site 420246009104 D-loop; other site 420246009105 H-loop/switch region; other site 420246009106 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 420246009107 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 420246009108 TM-ABC transporter signature motif; other site 420246009109 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246009110 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 420246009111 TM-ABC transporter signature motif; other site 420246009112 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 420246009113 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 420246009114 putative ligand binding site [chemical binding]; other site 420246009115 Transcriptional regulators [Transcription]; Region: GntR; COG1802 420246009116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246009117 DNA-binding site [nucleotide binding]; DNA binding site 420246009118 FCD domain; Region: FCD; pfam07729 420246009119 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 420246009120 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 420246009121 NAD binding site [chemical binding]; other site 420246009122 catalytic residues [active] 420246009123 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 420246009124 putative substrate binding pocket [chemical binding]; other site 420246009125 trimer interface [polypeptide binding]; other site 420246009126 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 420246009127 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 420246009128 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 420246009129 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 420246009130 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 420246009131 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 420246009132 dimer interface [polypeptide binding]; other site 420246009133 active site 420246009134 catalytic residue [active] 420246009135 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 420246009136 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 420246009137 tetramer interface [polypeptide binding]; other site 420246009138 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 420246009139 tetramer interface [polypeptide binding]; other site 420246009140 active site 420246009141 metal binding site [ion binding]; metal-binding site 420246009142 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 420246009143 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 420246009144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 420246009145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 420246009146 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 420246009147 dimerization interface [polypeptide binding]; other site 420246009148 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 420246009149 dimanganese center [ion binding]; other site 420246009150 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 420246009151 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 420246009152 catalytic residues [active] 420246009153 dimer interface [polypeptide binding]; other site 420246009154 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 420246009155 SmpB-tmRNA interface; other site 420246009156 ribonuclease R; Region: RNase_R; TIGR02063 420246009157 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 420246009158 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 420246009159 RNB domain; Region: RNB; pfam00773 420246009160 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 420246009161 RNA binding site [nucleotide binding]; other site 420246009162 Esterase/lipase [General function prediction only]; Region: COG1647 420246009163 Protein of unknown function (DUF677); Region: DUF677; pfam05055 420246009164 Preprotein translocase SecG subunit; Region: SecG; pfam03840 420246009165 Carboxylesterase family; Region: COesterase; pfam00135 420246009166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 420246009167 substrate binding pocket [chemical binding]; other site 420246009168 catalytic triad [active] 420246009169 enolase; Provisional; Region: eno; PRK00077 420246009170 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 420246009171 dimer interface [polypeptide binding]; other site 420246009172 metal binding site [ion binding]; metal-binding site 420246009173 substrate binding pocket [chemical binding]; other site 420246009174 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 420246009175 phosphoglyceromutase; Provisional; Region: PRK05434 420246009176 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 420246009177 triosephosphate isomerase; Provisional; Region: PRK14565 420246009178 substrate binding site [chemical binding]; other site 420246009179 dimer interface [polypeptide binding]; other site 420246009180 catalytic triad [active] 420246009181 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 420246009182 Phosphoglycerate kinase; Region: PGK; pfam00162 420246009183 substrate binding site [chemical binding]; other site 420246009184 hinge regions; other site 420246009185 ADP binding site [chemical binding]; other site 420246009186 catalytic site [active] 420246009187 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 420246009188 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 420246009189 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 420246009190 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 420246009191 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 420246009192 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 420246009193 catalytic residues [active] 420246009194 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 420246009195 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 420246009196 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 420246009197 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 420246009198 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 420246009199 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 420246009200 oligomer interface [polypeptide binding]; other site 420246009201 active site residues [active] 420246009202 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 420246009203 dimerization domain swap beta strand [polypeptide binding]; other site 420246009204 regulatory protein interface [polypeptide binding]; other site 420246009205 active site 420246009206 regulatory phosphorylation site [posttranslational modification]; other site 420246009207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 420246009208 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 420246009209 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 420246009210 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 420246009211 phosphate binding site [ion binding]; other site 420246009212 putative substrate binding pocket [chemical binding]; other site 420246009213 dimer interface [polypeptide binding]; other site 420246009214 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 420246009215 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 420246009216 putative active site [active] 420246009217 nucleotide binding site [chemical binding]; other site 420246009218 nudix motif; other site 420246009219 putative metal binding site [ion binding]; other site 420246009220 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 420246009221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 420246009222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 420246009223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 420246009224 binding surface 420246009225 Tetratricopeptide repeat; Region: TPR_16; pfam13432 420246009226 TPR motif; other site 420246009227 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 420246009228 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 420246009229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 420246009230 metal binding site [ion binding]; metal-binding site 420246009231 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 420246009232 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 420246009233 substrate binding site [chemical binding]; other site 420246009234 glutamase interaction surface [polypeptide binding]; other site 420246009235 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 420246009236 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 420246009237 catalytic residues [active] 420246009238 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 420246009239 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 420246009240 putative active site [active] 420246009241 oxyanion strand; other site 420246009242 catalytic triad [active] 420246009243 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 420246009244 putative active site pocket [active] 420246009245 4-fold oligomerization interface [polypeptide binding]; other site 420246009246 metal binding residues [ion binding]; metal-binding site 420246009247 3-fold/trimer interface [polypeptide binding]; other site 420246009248 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 420246009249 histidinol dehydrogenase; Region: hisD; TIGR00069 420246009250 NAD binding site [chemical binding]; other site 420246009251 dimerization interface [polypeptide binding]; other site 420246009252 product binding site; other site 420246009253 substrate binding site [chemical binding]; other site 420246009254 zinc binding site [ion binding]; other site 420246009255 catalytic residues [active] 420246009256 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 420246009257 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 420246009258 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 420246009259 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 420246009260 dimer interface [polypeptide binding]; other site 420246009261 motif 1; other site 420246009262 active site 420246009263 motif 2; other site 420246009264 motif 3; other site 420246009265 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 420246009266 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 420246009267 trimer interface [polypeptide binding]; other site 420246009268 active site 420246009269 substrate binding site [chemical binding]; other site 420246009270 CoA binding site [chemical binding]; other site 420246009271 pyrophosphatase PpaX; Provisional; Region: PRK13288 420246009272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 420246009273 active site 420246009274 motif I; other site 420246009275 motif II; other site 420246009276 Nucleoside recognition; Region: Gate; pfam07670 420246009277 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 420246009278 HPr kinase/phosphorylase; Provisional; Region: PRK05428 420246009279 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 420246009280 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 420246009281 Hpr binding site; other site 420246009282 active site 420246009283 homohexamer subunit interaction site [polypeptide binding]; other site 420246009284 Predicted membrane protein [Function unknown]; Region: COG1950 420246009285 Tic20-like protein; Region: Tic20; pfam09685 420246009286 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 420246009287 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 420246009288 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 420246009289 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 420246009290 excinuclease ABC subunit B; Provisional; Region: PRK05298 420246009291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246009292 ATP binding site [chemical binding]; other site 420246009293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246009294 nucleotide binding region [chemical binding]; other site 420246009295 ATP-binding site [chemical binding]; other site 420246009296 Ultra-violet resistance protein B; Region: UvrB; pfam12344 420246009297 UvrB/uvrC motif; Region: UVR; pfam02151 420246009298 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 420246009299 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 420246009300 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 420246009301 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 420246009302 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 420246009303 DNA binding residues [nucleotide binding] 420246009304 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 420246009305 C-terminal peptidase (prc); Region: prc; TIGR00225 420246009306 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 420246009307 protein binding site [polypeptide binding]; other site 420246009308 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 420246009309 Catalytic dyad [active] 420246009310 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 420246009311 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009312 Pirin-related protein [General function prediction only]; Region: COG1741 420246009313 Pirin; Region: Pirin; pfam02678 420246009314 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 420246009315 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 420246009316 Peptidase family M23; Region: Peptidase_M23; pfam01551 420246009317 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 420246009318 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 420246009319 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 420246009320 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 420246009321 Walker A/P-loop; other site 420246009322 ATP binding site [chemical binding]; other site 420246009323 Q-loop/lid; other site 420246009324 ABC transporter signature motif; other site 420246009325 Walker B; other site 420246009326 D-loop; other site 420246009327 H-loop/switch region; other site 420246009328 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 420246009329 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 420246009330 Uncharacterized conserved protein [Function unknown]; Region: COG1284 420246009331 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246009332 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 420246009333 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 420246009334 peptide chain release factor 2; Provisional; Region: PRK06746 420246009335 This domain is found in peptide chain release factors; Region: PCRF; smart00937 420246009336 RF-1 domain; Region: RF-1; pfam00472 420246009337 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 420246009338 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 420246009339 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 420246009340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246009341 nucleotide binding region [chemical binding]; other site 420246009342 ATP-binding site [chemical binding]; other site 420246009343 SEC-C motif; Region: SEC-C; pfam02810 420246009344 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 420246009345 30S subunit binding site; other site 420246009346 Flagellar protein FliT; Region: FliT; pfam05400 420246009347 flagellar protein FliS; Validated; Region: fliS; PRK05685 420246009348 flagellar capping protein; Validated; Region: fliD; PRK07737 420246009349 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 420246009350 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 420246009351 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 420246009352 flagellar protein FlaG; Provisional; Region: PRK07738 420246009353 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 420246009354 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 420246009355 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 420246009356 carbon storage regulator; Provisional; Region: PRK01712 420246009357 flagellar assembly protein FliW; Provisional; Region: PRK13285 420246009358 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 420246009359 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 420246009360 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 420246009361 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 420246009362 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 420246009363 FlgN protein; Region: FlgN; pfam05130 420246009364 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 420246009365 flagellar operon protein TIGR03826; Region: YvyF 420246009366 Protein of unknown function (DUF327); Region: DUF327; pfam03885 420246009367 flagellin; Provisional; Region: PRK12804 420246009368 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 420246009369 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 420246009370 Flagellar protein FliS; Region: FliS; cl00654 420246009371 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 420246009372 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 420246009373 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246009374 active site 420246009375 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 420246009376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246009377 ATP binding site [chemical binding]; other site 420246009378 putative Mg++ binding site [ion binding]; other site 420246009379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246009380 nucleotide binding region [chemical binding]; other site 420246009381 ATP-binding site [chemical binding]; other site 420246009382 EDD domain protein, DegV family; Region: DegV; TIGR00762 420246009383 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 420246009384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 420246009385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246009386 active site 420246009387 phosphorylation site [posttranslational modification] 420246009388 intermolecular recognition site; other site 420246009389 dimerization interface [polypeptide binding]; other site 420246009390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 420246009391 DNA binding residues [nucleotide binding] 420246009392 dimerization interface [polypeptide binding]; other site 420246009393 Sensor protein DegS; Region: DegS; pfam05384 420246009394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 420246009395 Histidine kinase; Region: HisKA_3; pfam07730 420246009396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246009397 ATP binding site [chemical binding]; other site 420246009398 Mg2+ binding site [ion binding]; other site 420246009399 G-X-G motif; other site 420246009400 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 420246009401 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 420246009402 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 420246009403 Transcriptional regulator [Transcription]; Region: LytR; COG1316 420246009404 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 420246009405 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 420246009406 Mg++ binding site [ion binding]; other site 420246009407 putative catalytic motif [active] 420246009408 substrate binding site [chemical binding]; other site 420246009409 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 420246009410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 420246009411 ATP binding site [chemical binding]; other site 420246009412 putative Mg++ binding site [ion binding]; other site 420246009413 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 420246009414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246009415 nucleotide binding region [chemical binding]; other site 420246009416 ATP-binding site [chemical binding]; other site 420246009417 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 420246009418 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 420246009419 Ligand binding site; other site 420246009420 Putative Catalytic site; other site 420246009421 DXD motif; other site 420246009422 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 420246009423 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 420246009424 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 420246009425 Bacterial SH3 domain; Region: SH3_3; cl17532 420246009426 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 420246009427 putative active site [active] 420246009428 putative metal binding site [ion binding]; other site 420246009429 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 420246009430 S-layer homology domain; Region: SLH; pfam00395 420246009431 S-layer homology domain; Region: SLH; pfam00395 420246009432 O-Antigen ligase; Region: Wzy_C; pfam04932 420246009433 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 420246009434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246009435 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 420246009436 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 420246009437 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 420246009438 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 420246009439 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 420246009440 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 420246009441 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 420246009442 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 420246009443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246009444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 420246009445 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 420246009446 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 420246009447 S-layer homology domain; Region: SLH; pfam00395 420246009448 S-layer homology domain; Region: SLH; pfam00395 420246009449 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 420246009450 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 420246009451 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 420246009452 active site 420246009453 catalytic residues [active] 420246009454 S-layer homology domain; Region: SLH; pfam00395 420246009455 S-layer homology domain; Region: SLH; pfam00395 420246009456 S-layer homology domain; Region: SLH; pfam00395 420246009457 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 420246009458 Bacterial SH3 domain; Region: SH3_3; pfam08239 420246009459 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 420246009460 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 420246009461 active site 420246009462 metal binding site [ion binding]; metal-binding site 420246009463 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 420246009464 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 420246009465 active site 420246009466 homodimer interface [polypeptide binding]; other site 420246009467 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 420246009468 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009469 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 420246009470 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009471 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009472 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009473 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 420246009474 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009475 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 420246009476 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 420246009477 NlpC/P60 family; Region: NLPC_P60; pfam00877 420246009478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 420246009479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246009480 non-specific DNA binding site [nucleotide binding]; other site 420246009481 salt bridge; other site 420246009482 sequence-specific DNA binding site [nucleotide binding]; other site 420246009483 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 420246009484 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 420246009485 dimer interface [polypeptide binding]; other site 420246009486 ssDNA binding site [nucleotide binding]; other site 420246009487 tetramer (dimer of dimers) interface [polypeptide binding]; other site 420246009488 YwpF-like protein; Region: YwpF; pfam14183 420246009489 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 420246009490 active site 420246009491 catalytic site [active] 420246009492 aspartate kinase; Reviewed; Region: PRK09034 420246009493 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 420246009494 putative catalytic residues [active] 420246009495 putative nucleotide binding site [chemical binding]; other site 420246009496 putative aspartate binding site [chemical binding]; other site 420246009497 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 420246009498 allosteric regulatory residue; other site 420246009499 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 420246009500 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 420246009501 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 420246009502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246009503 NAD(P) binding site [chemical binding]; other site 420246009504 catalytic residues [active] 420246009505 Protein of unknown function (DUF779); Region: DUF779; pfam05610 420246009506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246009507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 420246009508 putative substrate translocation pore; other site 420246009509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246009510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246009511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246009512 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 420246009513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 420246009514 nucleotide binding site [chemical binding]; other site 420246009515 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246009516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009517 dimer interface [polypeptide binding]; other site 420246009518 conserved gate region; other site 420246009519 putative PBP binding loops; other site 420246009520 ABC-ATPase subunit interface; other site 420246009521 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 420246009522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009523 dimer interface [polypeptide binding]; other site 420246009524 conserved gate region; other site 420246009525 putative PBP binding loops; other site 420246009526 ABC-ATPase subunit interface; other site 420246009527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246009528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 420246009529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246009530 Response regulator receiver domain; Region: Response_reg; pfam00072 420246009531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246009532 active site 420246009533 phosphorylation site [posttranslational modification] 420246009534 intermolecular recognition site; other site 420246009535 dimerization interface [polypeptide binding]; other site 420246009536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246009537 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 420246009538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246009539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 420246009540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246009541 dimerization interface [polypeptide binding]; other site 420246009542 Histidine kinase; Region: His_kinase; pfam06580 420246009543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246009544 ATP binding site [chemical binding]; other site 420246009545 Mg2+ binding site [ion binding]; other site 420246009546 G-X-G motif; other site 420246009547 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 420246009548 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 420246009549 ligand binding site [chemical binding]; other site 420246009550 Probable transposase; Region: OrfB_IS605; pfam01385 420246009551 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 420246009552 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 420246009553 gating phenylalanine in ion channel; other site 420246009554 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 420246009555 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 420246009556 NAD binding site [chemical binding]; other site 420246009557 sugar binding site [chemical binding]; other site 420246009558 divalent metal binding site [ion binding]; other site 420246009559 tetramer (dimer of dimers) interface [polypeptide binding]; other site 420246009560 dimer interface [polypeptide binding]; other site 420246009561 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 420246009562 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 420246009563 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 420246009564 putative active site [active] 420246009565 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 420246009566 beta-galactosidase; Region: BGL; TIGR03356 420246009567 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 420246009568 FAD binding domain; Region: FAD_binding_4; pfam01565 420246009569 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 420246009570 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 420246009571 alpha subunit interface [polypeptide binding]; other site 420246009572 TPP binding site [chemical binding]; other site 420246009573 heterodimer interface [polypeptide binding]; other site 420246009574 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 420246009575 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 420246009576 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 420246009577 TPP-binding site [chemical binding]; other site 420246009578 tetramer interface [polypeptide binding]; other site 420246009579 heterodimer interface [polypeptide binding]; other site 420246009580 phosphorylation loop region [posttranslational modification] 420246009581 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 420246009582 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 420246009583 E3 interaction surface; other site 420246009584 lipoyl attachment site [posttranslational modification]; other site 420246009585 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 420246009586 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 420246009587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 420246009588 putative metal binding site [ion binding]; other site 420246009589 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 420246009590 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 420246009591 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 420246009592 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 420246009593 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 420246009594 glutamate dehydrogenase; Provisional; Region: PRK09414 420246009595 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 420246009596 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 420246009597 NAD(P) binding site [chemical binding]; other site 420246009598 Bacteriophage Prd1, adsorption protein P2; Region: Prd1-P2; pfam09214 420246009599 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 420246009600 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 420246009601 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 420246009602 active site 420246009603 catalytic residues [active] 420246009604 metal binding site [ion binding]; metal-binding site 420246009605 DmpG-like communication domain; Region: DmpG_comm; pfam07836 420246009606 acetaldehyde dehydrogenase; Validated; Region: PRK08300 420246009607 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 420246009608 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 420246009609 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 420246009610 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 420246009611 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 420246009612 NAD binding site [chemical binding]; other site 420246009613 catalytic residues [active] 420246009614 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 420246009615 homotrimer interaction site [polypeptide binding]; other site 420246009616 putative active site [active] 420246009617 Amidohydrolase; Region: Amidohydro_2; pfam04909 420246009618 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 420246009619 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 420246009620 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 420246009621 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 420246009622 active site 420246009623 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 420246009624 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 420246009625 benzoate transport; Region: 2A0115; TIGR00895 420246009626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246009627 putative substrate translocation pore; other site 420246009628 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 420246009629 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 420246009630 ligand binding site [chemical binding]; other site 420246009631 flexible hinge region; other site 420246009632 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 420246009633 putative switch regulator; other site 420246009634 non-specific DNA interactions [nucleotide binding]; other site 420246009635 DNA binding site [nucleotide binding] 420246009636 sequence specific DNA binding site [nucleotide binding]; other site 420246009637 putative cAMP binding site [chemical binding]; other site 420246009638 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 420246009639 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 420246009640 ligand binding site [chemical binding]; other site 420246009641 flexible hinge region; other site 420246009642 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 420246009643 putative switch regulator; other site 420246009644 non-specific DNA interactions [nucleotide binding]; other site 420246009645 DNA binding site [nucleotide binding] 420246009646 sequence specific DNA binding site [nucleotide binding]; other site 420246009647 putative cAMP binding site [chemical binding]; other site 420246009648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246009649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246009650 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 420246009651 kynureninase; Region: kynureninase; TIGR01814 420246009652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 420246009653 catalytic residue [active] 420246009654 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 420246009655 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 420246009656 Putative cyclase; Region: Cyclase; cl00814 420246009657 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 420246009658 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 420246009659 ligand binding site [chemical binding]; other site 420246009660 dimerization interface [polypeptide binding]; other site 420246009661 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 420246009662 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 420246009663 TM-ABC transporter signature motif; other site 420246009664 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 420246009665 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 420246009666 Walker A/P-loop; other site 420246009667 ATP binding site [chemical binding]; other site 420246009668 Q-loop/lid; other site 420246009669 ABC transporter signature motif; other site 420246009670 Walker B; other site 420246009671 D-loop; other site 420246009672 H-loop/switch region; other site 420246009673 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 420246009674 D-ribose pyranase; Provisional; Region: PRK11797 420246009675 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 420246009676 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 420246009677 substrate binding site [chemical binding]; other site 420246009678 dimer interface [polypeptide binding]; other site 420246009679 ATP binding site [chemical binding]; other site 420246009680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246009681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246009682 DNA binding site [nucleotide binding] 420246009683 domain linker motif; other site 420246009684 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 420246009685 dimerization interface [polypeptide binding]; other site 420246009686 ligand binding site [chemical binding]; other site 420246009687 sodium binding site [ion binding]; other site 420246009688 Predicted integral membrane protein [Function unknown]; Region: COG5652 420246009689 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 420246009690 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 420246009691 Protein of unknown function (DUF819); Region: DUF819; pfam05684 420246009692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 420246009693 Transposase; Region: DDE_Tnp_ISL3; pfam01610 420246009694 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 420246009695 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 420246009696 active site 420246009697 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 420246009698 NlpC/P60 family; Region: NLPC_P60; pfam00877 420246009699 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 420246009700 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 420246009701 Na binding site [ion binding]; other site 420246009702 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 420246009703 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 420246009704 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 420246009705 metal binding site [ion binding]; metal-binding site 420246009706 dimer interface [polypeptide binding]; other site 420246009707 amidase, hydantoinase/carbamoylase family; Region: hydantase; TIGR01879 420246009708 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 420246009709 active site 420246009710 metal binding site [ion binding]; metal-binding site 420246009711 dimer interface [polypeptide binding]; other site 420246009712 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 420246009713 Bacterial SH3 domain homologues; Region: SH3b; smart00287 420246009714 Bacterial SH3 domain; Region: SH3_3; pfam08239 420246009715 Bacterial SH3 domain; Region: SH3_3; pfam08239 420246009716 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 420246009717 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 420246009718 active site 420246009719 metal binding site [ion binding]; metal-binding site 420246009720 SEC-C motif; Region: SEC-C; pfam02810 420246009721 SNF2 Helicase protein; Region: DUF3670; pfam12419 420246009722 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 420246009723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246009724 ATP binding site [chemical binding]; other site 420246009725 putative Mg++ binding site [ion binding]; other site 420246009726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 420246009727 nucleotide binding region [chemical binding]; other site 420246009728 ATP-binding site [chemical binding]; other site 420246009729 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 420246009730 putative active site [active] 420246009731 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 420246009732 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 420246009733 putative ADP-ribose binding site [chemical binding]; other site 420246009734 Uncharacterized conserved protein [Function unknown]; Region: COG3189 420246009735 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 420246009736 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 420246009737 active site 420246009738 tetramer interface; other site 420246009739 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 420246009740 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 420246009741 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 420246009742 active site 420246009743 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 420246009744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 420246009745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009746 dimer interface [polypeptide binding]; other site 420246009747 conserved gate region; other site 420246009748 ABC-ATPase subunit interface; other site 420246009749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 420246009750 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 420246009751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009752 putative PBP binding loops; other site 420246009753 dimer interface [polypeptide binding]; other site 420246009754 ABC-ATPase subunit interface; other site 420246009755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246009756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246009757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246009758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246009759 DNA binding site [nucleotide binding] 420246009760 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 420246009761 putative dimerization interface [polypeptide binding]; other site 420246009762 putative ligand binding site [chemical binding]; other site 420246009763 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 420246009764 EamA-like transporter family; Region: EamA; pfam00892 420246009765 EamA-like transporter family; Region: EamA; pfam00892 420246009766 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 420246009767 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 420246009768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 420246009769 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 420246009770 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 420246009771 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 420246009772 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 420246009773 active site 420246009774 homodimer interface [polypeptide binding]; other site 420246009775 catalytic site [active] 420246009776 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 420246009777 alpha-mannosidase; Provisional; Region: PRK09819 420246009778 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 420246009779 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 420246009780 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 420246009781 active site 420246009782 phosphorylation site [posttranslational modification] 420246009783 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 420246009784 active site 420246009785 P-loop; other site 420246009786 phosphorylation site [posttranslational modification] 420246009787 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 420246009788 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 420246009789 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 420246009790 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 420246009791 putative active site [active] 420246009792 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 420246009793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246009794 FeS/SAM binding site; other site 420246009795 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 420246009796 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 420246009797 hydroxyglutarate oxidase; Provisional; Region: PRK11728 420246009798 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 420246009799 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 420246009800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009801 dimer interface [polypeptide binding]; other site 420246009802 conserved gate region; other site 420246009803 putative PBP binding loops; other site 420246009804 ABC-ATPase subunit interface; other site 420246009805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 420246009806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009807 putative PBP binding loops; other site 420246009808 dimer interface [polypeptide binding]; other site 420246009809 ABC-ATPase subunit interface; other site 420246009810 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 420246009811 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 420246009812 Walker A/P-loop; other site 420246009813 ATP binding site [chemical binding]; other site 420246009814 Q-loop/lid; other site 420246009815 ABC transporter signature motif; other site 420246009816 Walker B; other site 420246009817 D-loop; other site 420246009818 H-loop/switch region; other site 420246009819 TOBE domain; Region: TOBE_2; pfam08402 420246009820 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 420246009821 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 420246009822 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 420246009823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 420246009824 DNA-binding site [nucleotide binding]; DNA binding site 420246009825 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 420246009826 Propionate catabolism activator; Region: PrpR_N; pfam06506 420246009827 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 420246009828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 420246009829 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 420246009830 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 420246009831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 420246009832 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 420246009833 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 420246009834 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 420246009835 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 420246009836 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 420246009837 putative metal binding site [ion binding]; other site 420246009838 dimer interface [polypeptide binding]; other site 420246009839 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 420246009840 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 420246009841 putative metal binding site [ion binding]; other site 420246009842 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 420246009843 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 420246009844 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 420246009845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 420246009846 nucleotide binding site [chemical binding]; other site 420246009847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 420246009848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009849 dimer interface [polypeptide binding]; other site 420246009850 conserved gate region; other site 420246009851 putative PBP binding loops; other site 420246009852 ABC-ATPase subunit interface; other site 420246009853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246009854 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 420246009855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 420246009856 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 420246009857 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 420246009858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246009859 Coenzyme A binding pocket [chemical binding]; other site 420246009860 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 420246009861 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 420246009862 Transposase IS200 like; Region: Y1_Tnp; pfam01797 420246009863 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 420246009864 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 420246009865 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 420246009866 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 420246009867 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 420246009868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 420246009869 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 420246009870 DNA binding site [nucleotide binding] 420246009871 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 420246009872 putative dimerization interface [polypeptide binding]; other site 420246009873 putative ligand binding site [chemical binding]; other site 420246009874 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 420246009875 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 420246009876 putative ADP-binding pocket [chemical binding]; other site 420246009877 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 420246009878 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 420246009879 active site 420246009880 DDE superfamily endonuclease; Region: DDE_3; pfam13358 420246009881 Winged helix-turn helix; Region: HTH_29; pfam13551 420246009882 Homeodomain-like domain; Region: HTH_23; cl17451 420246009883 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 420246009884 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 420246009885 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 420246009886 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 420246009887 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 420246009888 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 420246009889 active site 420246009890 nucleotide binding site [chemical binding]; other site 420246009891 HIGH motif; other site 420246009892 KMSKS motif; other site 420246009893 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 420246009894 Bacterial sugar transferase; Region: Bac_transf; pfam02397 420246009895 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 420246009896 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 420246009897 active site 420246009898 tetramer interface; other site 420246009899 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 420246009900 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 420246009901 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 420246009902 active site 420246009903 oxyanion hole [active] 420246009904 catalytic triad [active] 420246009905 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 420246009906 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 420246009907 Nucleotide binding site [chemical binding]; other site 420246009908 DTAP/Switch II; other site 420246009909 Switch I; other site 420246009910 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 420246009911 Chain length determinant protein; Region: Wzz; cl15801 420246009912 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 420246009913 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 420246009914 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 420246009915 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 420246009916 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 420246009917 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 420246009918 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 420246009919 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 420246009920 rod shape-determining protein Mbl; Provisional; Region: PRK13928 420246009921 MreB and similar proteins; Region: MreB_like; cd10225 420246009922 nucleotide binding site [chemical binding]; other site 420246009923 Mg binding site [ion binding]; other site 420246009924 putative protofilament interaction site [polypeptide binding]; other site 420246009925 RodZ interaction site [polypeptide binding]; other site 420246009926 Stage III sporulation protein D; Region: SpoIIID; pfam12116 420246009927 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 420246009928 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 420246009929 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 420246009930 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 420246009931 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 420246009932 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 420246009933 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246009934 Walker A/P-loop; other site 420246009935 ATP binding site [chemical binding]; other site 420246009936 Q-loop/lid; other site 420246009937 ABC transporter signature motif; other site 420246009938 Walker B; other site 420246009939 D-loop; other site 420246009940 H-loop/switch region; other site 420246009941 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246009942 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 420246009943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 420246009944 Walker A/P-loop; other site 420246009945 ATP binding site [chemical binding]; other site 420246009946 Q-loop/lid; other site 420246009947 ABC transporter signature motif; other site 420246009948 Walker B; other site 420246009949 D-loop; other site 420246009950 H-loop/switch region; other site 420246009951 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 420246009952 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 420246009953 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 420246009954 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 420246009955 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 420246009956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009957 dimer interface [polypeptide binding]; other site 420246009958 conserved gate region; other site 420246009959 putative PBP binding loops; other site 420246009960 ABC-ATPase subunit interface; other site 420246009961 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 420246009962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246009963 dimer interface [polypeptide binding]; other site 420246009964 conserved gate region; other site 420246009965 putative PBP binding loops; other site 420246009966 ABC-ATPase subunit interface; other site 420246009967 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 420246009968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 420246009969 putative DNA binding site [nucleotide binding]; other site 420246009970 putative Zn2+ binding site [ion binding]; other site 420246009971 AsnC family; Region: AsnC_trans_reg; pfam01037 420246009972 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 420246009973 Peptidase family M23; Region: Peptidase_M23; pfam01551 420246009974 stage II sporulation protein D; Region: spore_II_D; TIGR02870 420246009975 Stage II sporulation protein; Region: SpoIID; pfam08486 420246009976 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 420246009977 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 420246009978 hinge; other site 420246009979 active site 420246009980 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 420246009981 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 420246009982 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 420246009983 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 420246009984 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 420246009985 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 420246009986 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 420246009987 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 420246009988 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 420246009989 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 420246009990 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 420246009991 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 420246009992 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 420246009993 4Fe-4S binding domain; Region: Fer4; cl02805 420246009994 4Fe-4S binding domain; Region: Fer4; pfam00037 420246009995 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 420246009996 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 420246009997 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 420246009998 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 420246009999 NADH dehydrogenase subunit C; Validated; Region: PRK07735 420246010000 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 420246010001 NADH dehydrogenase subunit B; Validated; Region: PRK06411 420246010002 NADH dehydrogenase subunit A; Validated; Region: PRK07756 420246010003 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 420246010004 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 420246010005 gamma subunit interface [polypeptide binding]; other site 420246010006 epsilon subunit interface [polypeptide binding]; other site 420246010007 LBP interface [polypeptide binding]; other site 420246010008 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 420246010009 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 420246010010 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 420246010011 alpha subunit interaction interface [polypeptide binding]; other site 420246010012 Walker A motif; other site 420246010013 ATP binding site [chemical binding]; other site 420246010014 Walker B motif; other site 420246010015 inhibitor binding site; inhibition site 420246010016 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 420246010017 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 420246010018 core domain interface [polypeptide binding]; other site 420246010019 delta subunit interface [polypeptide binding]; other site 420246010020 epsilon subunit interface [polypeptide binding]; other site 420246010021 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 420246010022 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 420246010023 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 420246010024 beta subunit interaction interface [polypeptide binding]; other site 420246010025 Walker A motif; other site 420246010026 ATP binding site [chemical binding]; other site 420246010027 Walker B motif; other site 420246010028 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 420246010029 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 420246010030 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 420246010031 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 420246010032 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 420246010033 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 420246010034 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 420246010035 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 420246010036 ATP synthase I chain; Region: ATP_synt_I; pfam03899 420246010037 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 420246010038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 420246010039 active site 420246010040 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 420246010041 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 420246010042 dimer interface [polypeptide binding]; other site 420246010043 active site 420246010044 glycine-pyridoxal phosphate binding site [chemical binding]; other site 420246010045 folate binding site [chemical binding]; other site 420246010046 hypothetical protein; Provisional; Region: PRK13690 420246010047 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 420246010048 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 420246010049 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246010050 dimerization interface [polypeptide binding]; other site 420246010051 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 420246010052 dimer interface [polypeptide binding]; other site 420246010053 putative CheW interface [polypeptide binding]; other site 420246010054 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 420246010055 Low molecular weight phosphatase family; Region: LMWPc; cd00115 420246010056 active site 420246010057 Predicted membrane protein [Function unknown]; Region: COG1971 420246010058 Domain of unknown function DUF; Region: DUF204; pfam02659 420246010059 Domain of unknown function DUF; Region: DUF204; pfam02659 420246010060 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 420246010061 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 420246010062 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 420246010063 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 420246010064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246010065 S-adenosylmethionine binding site [chemical binding]; other site 420246010066 peptide chain release factor 1; Validated; Region: prfA; PRK00591 420246010067 This domain is found in peptide chain release factors; Region: PCRF; smart00937 420246010068 RF-1 domain; Region: RF-1; pfam00472 420246010069 thymidine kinase; Provisional; Region: PRK04296 420246010070 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 420246010071 transcription termination factor Rho; Provisional; Region: rho; PRK09376 420246010072 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 420246010073 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 420246010074 RNA binding site [nucleotide binding]; other site 420246010075 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 420246010076 multimer interface [polypeptide binding]; other site 420246010077 Walker A motif; other site 420246010078 ATP binding site [chemical binding]; other site 420246010079 Walker B motif; other site 420246010080 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 420246010081 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 420246010082 putative active site [active] 420246010083 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 420246010084 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 420246010085 hinge; other site 420246010086 active site 420246010087 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 420246010088 active site 420246010089 intersubunit interactions; other site 420246010090 catalytic residue [active] 420246010091 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 420246010092 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 420246010093 intersubunit interface [polypeptide binding]; other site 420246010094 active site 420246010095 zinc binding site [ion binding]; other site 420246010096 Na+ binding site [ion binding]; other site 420246010097 Response regulator receiver domain; Region: Response_reg; pfam00072 420246010098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246010099 active site 420246010100 phosphorylation site [posttranslational modification] 420246010101 intermolecular recognition site; other site 420246010102 dimerization interface [polypeptide binding]; other site 420246010103 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 420246010104 CTP synthetase; Validated; Region: pyrG; PRK05380 420246010105 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 420246010106 Catalytic site [active] 420246010107 active site 420246010108 UTP binding site [chemical binding]; other site 420246010109 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 420246010110 active site 420246010111 putative oxyanion hole; other site 420246010112 catalytic triad [active] 420246010113 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 420246010114 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 420246010115 B12 binding site [chemical binding]; other site 420246010116 cobalt ligand [ion binding]; other site 420246010117 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 420246010118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 420246010119 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 420246010120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 420246010121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 420246010122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246010123 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 420246010124 FAD binding site [chemical binding]; other site 420246010125 homotetramer interface [polypeptide binding]; other site 420246010126 substrate binding pocket [chemical binding]; other site 420246010127 catalytic base [active] 420246010128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 420246010129 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 420246010130 FAD binding site [chemical binding]; other site 420246010131 homotetramer interface [polypeptide binding]; other site 420246010132 substrate binding pocket [chemical binding]; other site 420246010133 catalytic base [active] 420246010134 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 420246010135 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 420246010136 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 420246010137 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 420246010138 4Fe-4S binding domain; Region: Fer4; cl02805 420246010139 Cysteine-rich domain; Region: CCG; pfam02754 420246010140 Cysteine-rich domain; Region: CCG; pfam02754 420246010141 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 420246010142 putative active site [active] 420246010143 catalytic site [active] 420246010144 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 420246010145 PLD-like domain; Region: PLDc_2; pfam13091 420246010146 putative active site [active] 420246010147 catalytic site [active] 420246010148 XapX domain; Region: XapX; TIGR03510 420246010149 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 420246010150 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 420246010151 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 420246010152 active site 420246010153 HIGH motif; other site 420246010154 KMSK motif region; other site 420246010155 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 420246010156 tRNA binding surface [nucleotide binding]; other site 420246010157 anticodon binding site; other site 420246010158 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 420246010159 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 420246010160 agmatinase; Region: agmatinase; TIGR01230 420246010161 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 420246010162 putative active site [active] 420246010163 Mn binding site [ion binding]; other site 420246010164 spermidine synthase; Provisional; Region: PRK00811 420246010165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246010166 Transglycosylase; Region: Transgly; pfam00912 420246010167 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 420246010168 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 420246010169 YwhD family; Region: YwhD; pfam08741 420246010170 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 420246010171 Peptidase family M50; Region: Peptidase_M50; pfam02163 420246010172 active site 420246010173 putative substrate binding region [chemical binding]; other site 420246010174 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 420246010175 active site 1 [active] 420246010176 dimer interface [polypeptide binding]; other site 420246010177 hexamer interface [polypeptide binding]; other site 420246010178 active site 2 [active] 420246010179 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 420246010180 Uncharacterized conserved protein [Function unknown]; Region: COG3465 420246010181 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 420246010182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 420246010183 Zn2+ binding site [ion binding]; other site 420246010184 Mg2+ binding site [ion binding]; other site 420246010185 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 420246010186 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 420246010187 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 420246010188 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 420246010189 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 420246010190 putative heme peroxidase; Provisional; Region: PRK12276 420246010191 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 420246010192 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 420246010193 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 420246010194 UbiA prenyltransferase family; Region: UbiA; pfam01040 420246010195 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 420246010196 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 420246010197 ligand binding site [chemical binding]; other site 420246010198 active site 420246010199 UGI interface [polypeptide binding]; other site 420246010200 catalytic site [active] 420246010201 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 420246010202 anti sigma factor interaction site; other site 420246010203 regulatory phosphorylation site [posttranslational modification]; other site 420246010204 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 420246010205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246010206 ATP binding site [chemical binding]; other site 420246010207 Mg2+ binding site [ion binding]; other site 420246010208 G-X-G motif; other site 420246010209 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 420246010210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 420246010211 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 420246010212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 420246010213 DNA binding residues [nucleotide binding] 420246010214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246010215 PAS domain; Region: PAS_9; pfam13426 420246010216 putative active site [active] 420246010217 heme pocket [chemical binding]; other site 420246010218 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 420246010219 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 420246010220 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 420246010221 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 420246010222 glycyl-tRNA synthetase; Provisional; Region: PRK04173 420246010223 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 420246010224 motif 1; other site 420246010225 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 420246010226 active site 420246010227 motif 2; other site 420246010228 motif 3; other site 420246010229 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 420246010230 anticodon binding site; other site 420246010231 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 420246010232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 420246010233 active site 420246010234 benzoate transport; Region: 2A0115; TIGR00895 420246010235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 420246010236 putative substrate translocation pore; other site 420246010237 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 420246010238 HPr interaction site; other site 420246010239 glycerol kinase (GK) interaction site [polypeptide binding]; other site 420246010240 active site 420246010241 phosphorylation site [posttranslational modification] 420246010242 tartrate dehydrogenase; Provisional; Region: PRK08194 420246010243 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 420246010244 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 420246010245 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 420246010246 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 420246010247 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 420246010248 hexamer interface [polypeptide binding]; other site 420246010249 ligand binding site [chemical binding]; other site 420246010250 putative active site [active] 420246010251 NAD(P) binding site [chemical binding]; other site 420246010252 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 420246010253 dimer interface [polypeptide binding]; other site 420246010254 substrate binding site [chemical binding]; other site 420246010255 ATP binding site [chemical binding]; other site 420246010256 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 420246010257 Na binding site [ion binding]; other site 420246010258 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 420246010259 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 420246010260 substrate binding pocket [chemical binding]; other site 420246010261 membrane-bound complex binding site; other site 420246010262 hinge residues; other site 420246010263 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 420246010264 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 420246010265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 420246010266 dimer interface [polypeptide binding]; other site 420246010267 conserved gate region; other site 420246010268 putative PBP binding loops; other site 420246010269 ABC-ATPase subunit interface; other site 420246010270 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 420246010271 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 420246010272 Walker A/P-loop; other site 420246010273 ATP binding site [chemical binding]; other site 420246010274 Q-loop/lid; other site 420246010275 ABC transporter signature motif; other site 420246010276 Walker B; other site 420246010277 D-loop; other site 420246010278 H-loop/switch region; other site 420246010279 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 420246010280 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 420246010281 Subunit I/III interface [polypeptide binding]; other site 420246010282 Subunit III/IV interface [polypeptide binding]; other site 420246010283 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 420246010284 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 420246010285 D-pathway; other site 420246010286 Putative ubiquinol binding site [chemical binding]; other site 420246010287 Low-spin heme (heme b) binding site [chemical binding]; other site 420246010288 Putative water exit pathway; other site 420246010289 Binuclear center (heme o3/CuB) [ion binding]; other site 420246010290 K-pathway; other site 420246010291 Putative proton exit pathway; other site 420246010292 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 420246010293 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 420246010294 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 420246010295 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 420246010296 Spore germination protein; Region: Spore_permease; cl17796 420246010297 putative transposase OrfB; Reviewed; Region: PHA02517 420246010298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246010299 Transposase; Region: HTH_Tnp_1; cl17663 420246010300 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 420246010301 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 420246010302 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 420246010303 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 420246010304 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 420246010305 [2Fe-2S] cluster binding site [ion binding]; other site 420246010306 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 420246010307 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 420246010308 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 420246010309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 420246010310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 420246010311 metal binding site [ion binding]; metal-binding site 420246010312 active site 420246010313 I-site; other site 420246010314 MarR family; Region: MarR; pfam01047 420246010315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246010316 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246010317 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 420246010318 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 420246010319 NodB motif; other site 420246010320 putative active site [active] 420246010321 putative catalytic site [active] 420246010322 putative Zn binding site [ion binding]; other site 420246010323 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246010324 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246010325 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 420246010326 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 420246010327 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 420246010328 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 420246010329 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 420246010330 protein binding site [polypeptide binding]; other site 420246010331 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 420246010332 YycH protein; Region: YycI; pfam09648 420246010333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 420246010334 YycH protein; Region: YycH; pfam07435 420246010335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 420246010336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 420246010337 dimerization interface [polypeptide binding]; other site 420246010338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 420246010339 putative active site [active] 420246010340 heme pocket [chemical binding]; other site 420246010341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 420246010342 dimer interface [polypeptide binding]; other site 420246010343 phosphorylation site [posttranslational modification] 420246010344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 420246010345 ATP binding site [chemical binding]; other site 420246010346 Mg2+ binding site [ion binding]; other site 420246010347 G-X-G motif; other site 420246010348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 420246010349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 420246010350 active site 420246010351 phosphorylation site [posttranslational modification] 420246010352 intermolecular recognition site; other site 420246010353 dimerization interface [polypeptide binding]; other site 420246010354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 420246010355 DNA binding site [nucleotide binding] 420246010356 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 420246010357 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 420246010358 GDP-binding site [chemical binding]; other site 420246010359 ACT binding site; other site 420246010360 IMP binding site; other site 420246010361 replicative DNA helicase; Provisional; Region: PRK05748 420246010362 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 420246010363 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 420246010364 Walker A motif; other site 420246010365 ATP binding site [chemical binding]; other site 420246010366 Walker B motif; other site 420246010367 DNA binding loops [nucleotide binding] 420246010368 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 420246010369 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 420246010370 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 420246010371 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 420246010372 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 420246010373 DHH family; Region: DHH; pfam01368 420246010374 DHHA1 domain; Region: DHHA1; pfam02272 420246010375 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 420246010376 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899 420246010377 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 420246010378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246010379 active site 420246010380 DNA binding site [nucleotide binding] 420246010381 Int/Topo IB signature motif; other site 420246010382 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 420246010383 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246010384 active site 420246010385 DNA binding site [nucleotide binding] 420246010386 Int/Topo IB signature motif; other site 420246010387 SH3 domain-containing protein; Provisional; Region: PRK10884 420246010388 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 420246010389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 420246010390 Coenzyme A binding pocket [chemical binding]; other site 420246010391 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 420246010392 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 420246010393 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 420246010394 dimer interface [polypeptide binding]; other site 420246010395 ssDNA binding site [nucleotide binding]; other site 420246010396 tetramer (dimer of dimers) interface [polypeptide binding]; other site 420246010397 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 420246010398 GTP-binding protein YchF; Reviewed; Region: PRK09601 420246010399 YchF GTPase; Region: YchF; cd01900 420246010400 G1 box; other site 420246010401 GTP/Mg2+ binding site [chemical binding]; other site 420246010402 Switch I region; other site 420246010403 G2 box; other site 420246010404 Switch II region; other site 420246010405 G3 box; other site 420246010406 G4 box; other site 420246010407 G5 box; other site 420246010408 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 420246010409 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 420246010410 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 420246010411 Mechanosensitive ion channel; Region: MS_channel; pfam00924 420246010412 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 420246010413 Protein of unknown function (DUF554); Region: DUF554; pfam04474 420246010414 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 420246010415 ParB-like nuclease domain; Region: ParB; smart00470 420246010416 KorB domain; Region: KorB; pfam08535 420246010417 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 420246010418 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 420246010419 P-loop; other site 420246010420 Magnesium ion binding site [ion binding]; other site 420246010421 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 420246010422 Magnesium ion binding site [ion binding]; other site 420246010423 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 420246010424 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 420246010425 ParB-like nuclease domain; Region: ParBc; pfam02195 420246010426 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 420246010427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 420246010428 S-adenosylmethionine binding site [chemical binding]; other site 420246010429 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 420246010430 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 420246010431 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 420246010432 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 420246010433 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 420246010434 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 420246010435 trmE is a tRNA modification GTPase; Region: trmE; cd04164 420246010436 G1 box; other site 420246010437 GTP/Mg2+ binding site [chemical binding]; other site 420246010438 Switch I region; other site 420246010439 G2 box; other site 420246010440 Switch II region; other site 420246010441 G3 box; other site 420246010442 G4 box; other site 420246010443 G5 box; other site 420246010444 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 420246010445 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 420246010446 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 420246010447 G-X-X-G motif; other site 420246010448 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 420246010449 RxxxH motif; other site 420246010450 OxaA-like protein precursor; Validated; Region: PRK02944 420246010451 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 420246010452 ribonuclease P; Reviewed; Region: rnpA; PRK00499 420246010453 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 420246010454 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246010455 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 420246010456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 420246010457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246010458 sequence-specific DNA binding site [nucleotide binding]; other site 420246010459 salt bridge; other site 420246010460 Integrase core domain; Region: rve; pfam00665 420246010461 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 420246010462 MPN+ (JAMM) motif; other site 420246010463 Zinc-binding site [ion binding]; other site 420246010464 Munc13 (mammalian uncoordinated) homology domain; Region: Membr_traf_MHD; pfam10540 420246010465 seryl-tRNA synthetase; Provisional; Region: PRK05431 420246010466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 420246010467 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 420246010468 Peptidase family M23; Region: Peptidase_M23; pfam01551 420246010469 Immunoglobulin domain; Region: Ig; cl11960 420246010470 Domain of unknown function DUF87; Region: DUF87; pfam01935 420246010471 AAA-like domain; Region: AAA_10; pfam12846 420246010472 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 420246010473 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 420246010474 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 420246010475 DNA binding residues [nucleotide binding] 420246010476 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 420246010477 putative active site [active] 420246010478 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 420246010479 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 420246010480 Replication-relaxation; Region: Replic_Relax; pfam13814 420246010481 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 420246010482 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 420246010483 Mg binding site [ion binding]; other site 420246010484 nucleotide binding site [chemical binding]; other site 420246010485 putative protofilament interface [polypeptide binding]; other site 420246010486 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 420246010487 Transposase domain (DUF772); Region: DUF772; pfam05598 420246010488 V-type ATP synthase subunit I; Validated; Region: PRK05771 420246010489 MobA/MobL family; Region: MobA_MobL; pfam03389 420246010490 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 420246010491 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 420246010492 Walker A motif; other site 420246010493 ATP binding site [chemical binding]; other site 420246010494 Walker B motif; other site 420246010495 DNA topoisomerase III; Provisional; Region: PRK07726 420246010496 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 420246010497 active site 420246010498 putative interdomain interaction site [polypeptide binding]; other site 420246010499 putative metal-binding site [ion binding]; other site 420246010500 putative nucleotide binding site [chemical binding]; other site 420246010501 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 420246010502 domain I; other site 420246010503 DNA binding groove [nucleotide binding] 420246010504 phosphate binding site [ion binding]; other site 420246010505 domain II; other site 420246010506 domain III; other site 420246010507 nucleotide binding site [chemical binding]; other site 420246010508 catalytic site [active] 420246010509 domain IV; other site 420246010510 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 420246010511 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 420246010512 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 420246010513 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 420246010514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 420246010515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 420246010516 sequence-specific DNA binding site [nucleotide binding]; other site 420246010517 salt bridge; other site 420246010518 Integrase core domain; Region: rve; pfam00665 420246010519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 420246010520 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 420246010521 Walker A motif; other site 420246010522 ATP binding site [chemical binding]; other site 420246010523 Walker B motif; other site 420246010524 arginine finger; other site 420246010525 hypothetical protein; Reviewed; Region: PRK00024 420246010526 Superfamily II helicase [General function prediction only]; Region: COG1204 420246010527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 420246010528 Transposase; Region: HTH_Tnp_1; pfam01527 420246010529 putative transposase OrfB; Reviewed; Region: PHA02517 420246010530 HTH-like domain; Region: HTH_21; pfam13276 420246010531 Integrase core domain; Region: rve; pfam00665 420246010532 Integrase core domain; Region: rve_3; pfam13683 420246010533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 420246010534 ATP binding site [chemical binding]; other site 420246010535 putative Mg++ binding site [ion binding]; other site 420246010536 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 420246010537 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 420246010538 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 420246010539 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 420246010540 active site 420246010541 DNA binding site [nucleotide binding] 420246010542 Int/Topo IB signature motif; other site 420246010543 Catalytic domain of Protein Kinases; Region: PKc; cd00180 420246010544 active site 420246010545 ATP binding site [chemical binding]; other site 420246010546 substrate binding site [chemical binding]; other site 420246010547 DDE superfamily endonuclease; Region: DDE_5; cl17874 420246010548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 420246010549 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 420246010550 Transposase [DNA replication, recombination, and repair]; Region: COG5421 420246010551 H+ Antiporter protein; Region: 2A0121; TIGR00900 420246010552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 420246010553 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 420246010554 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 420246010555 N-terminal domain interface [polypeptide binding]; other site 420246010556 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 420246010557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 420246010558 FeS/SAM binding site; other site 420246010559 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 420246010560 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 420246010561 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 420246010562 active site 420246010563 non-prolyl cis peptide bond; other site