-- dump date   	20140619_100212
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
298654000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
298654000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000003	Walker A motif; other site
298654000004	ATP binding site [chemical binding]; other site
298654000005	Walker B motif; other site
298654000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298654000007	arginine finger; other site
298654000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
298654000009	DnaA box-binding interface [nucleotide binding]; other site
298654000010	DNA polymerase III subunit beta; Validated; Region: PRK07761
298654000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
298654000012	putative DNA binding surface [nucleotide binding]; other site
298654000013	dimer interface [polypeptide binding]; other site
298654000014	beta-clamp/clamp loader binding surface; other site
298654000015	beta-clamp/translesion DNA polymerase binding surface; other site
298654000016	recombination protein F; Reviewed; Region: recF; PRK00064
298654000017	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
298654000018	Walker A/P-loop; other site
298654000019	ATP binding site [chemical binding]; other site
298654000020	Q-loop/lid; other site
298654000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654000022	ABC transporter signature motif; other site
298654000023	Walker B; other site
298654000024	D-loop; other site
298654000025	H-loop/switch region; other site
298654000026	Protein of unknown function (DUF721); Region: DUF721; cl02324
298654000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
298654000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654000029	ATP binding site [chemical binding]; other site
298654000030	Mg2+ binding site [ion binding]; other site
298654000031	G-X-G motif; other site
298654000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
298654000033	anchoring element; other site
298654000034	dimer interface [polypeptide binding]; other site
298654000035	ATP binding site [chemical binding]; other site
298654000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
298654000037	active site
298654000038	putative metal-binding site [ion binding]; other site
298654000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
298654000040	DNA gyrase subunit A; Validated; Region: PRK05560
298654000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
298654000042	CAP-like domain; other site
298654000043	active site
298654000044	primary dimer interface [polypeptide binding]; other site
298654000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298654000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298654000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298654000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298654000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298654000050	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
298654000051	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654000052	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654000053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654000054	S-adenosylmethionine binding site [chemical binding]; other site
298654000055	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
298654000056	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
298654000057	Methyltransferase domain; Region: Methyltransf_24; pfam13578
298654000058	PQQ-like domain; Region: PQQ_2; pfam13360
298654000059	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
298654000060	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
298654000061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654000062	sequence-specific DNA binding site [nucleotide binding]; other site
298654000063	salt bridge; other site
298654000064	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
298654000065	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
298654000066	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654000067	Helix-turn-helix domain; Region: HTH_17; cl17695
298654000068	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
298654000069	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
298654000070	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
298654000071	Int/Topo IB signature motif; other site
298654000072	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298654000073	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654000074	P-loop; other site
298654000075	Magnesium ion binding site [ion binding]; other site
298654000076	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654000077	Magnesium ion binding site [ion binding]; other site
298654000078	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
298654000079	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654000080	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
298654000081	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654000082	Walker A/P-loop; other site
298654000083	ATP binding site [chemical binding]; other site
298654000084	Q-loop/lid; other site
298654000085	ABC transporter signature motif; other site
298654000086	Walker B; other site
298654000087	D-loop; other site
298654000088	H-loop/switch region; other site
298654000089	TOBE domain; Region: TOBE_2; pfam08402
298654000090	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
298654000091	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
298654000092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000093	dimer interface [polypeptide binding]; other site
298654000094	conserved gate region; other site
298654000095	putative PBP binding loops; other site
298654000096	ABC-ATPase subunit interface; other site
298654000097	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
298654000098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000099	dimer interface [polypeptide binding]; other site
298654000100	conserved gate region; other site
298654000101	putative PBP binding loops; other site
298654000102	ABC-ATPase subunit interface; other site
298654000103	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
298654000104	substrate binding site [chemical binding]; other site
298654000105	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
298654000106	Nitrogen regulatory protein P-II; Region: P-II; smart00938
298654000107	Secretory lipase; Region: LIP; pfam03583
298654000108	Predicted flavoprotein [General function prediction only]; Region: COG0431
298654000109	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298654000110	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654000111	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298654000112	nucleotide binding site [chemical binding]; other site
298654000113	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654000114	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654000115	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
298654000116	Leucine carboxyl methyltransferase; Region: LCM; cl01306
298654000117	OsmC-like protein; Region: OsmC; pfam02566
298654000118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654000119	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
298654000120	Methyltransferase domain; Region: Methyltransf_11; pfam08241
298654000121	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
298654000122	putative glycosyl transferase; Provisional; Region: PRK10307
298654000123	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
298654000124	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
298654000125	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654000126	NAD(P) binding site [chemical binding]; other site
298654000127	active site
298654000128	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
298654000129	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
298654000130	active site
298654000131	homodimer interface [polypeptide binding]; other site
298654000132	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
298654000133	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
298654000134	adenosine deaminase; Provisional; Region: PRK09358
298654000135	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298654000136	active site
298654000137	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
298654000138	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
298654000139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
298654000140	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
298654000141	major facilitator 4 family protein; Region: 2A0129; TIGR00903
298654000142	major facilitator 4 family protein; Region: 2A0129; TIGR00903
298654000143	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654000144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654000145	active site
298654000146	phosphorylation site [posttranslational modification]
298654000147	intermolecular recognition site; other site
298654000148	dimerization interface [polypeptide binding]; other site
298654000149	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654000150	DNA binding residues [nucleotide binding]
298654000151	dimerization interface [polypeptide binding]; other site
298654000152	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654000153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654000154	S-adenosylmethionine binding site [chemical binding]; other site
298654000155	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
298654000156	amidase catalytic site [active]
298654000157	substrate binding site [chemical binding]; other site
298654000158	Zn binding residues [ion binding]; other site
298654000159	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654000160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654000161	Coenzyme A binding pocket [chemical binding]; other site
298654000162	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
298654000163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654000164	Coenzyme A binding pocket [chemical binding]; other site
298654000165	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
298654000166	Adenosylhomocysteinase; Provisional; Region: PTZ00075
298654000167	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
298654000168	homotetramer interface [polypeptide binding]; other site
298654000169	ligand binding site [chemical binding]; other site
298654000170	catalytic site [active]
298654000171	NAD binding site [chemical binding]; other site
298654000172	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
298654000173	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
298654000174	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654000175	dimer interface [polypeptide binding]; other site
298654000176	active site
298654000177	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
298654000178	catalytic site [active]
298654000179	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298654000180	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298654000181	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
298654000182	active site
298654000183	Rhomboid family; Region: Rhomboid; pfam01694
298654000184	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654000185	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
298654000186	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
298654000187	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
298654000188	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
298654000189	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
298654000190	Glutamine amidotransferase class-I; Region: GATase; pfam00117
298654000191	glutamine binding [chemical binding]; other site
298654000192	catalytic triad [active]
298654000193	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654000194	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654000195	active site
298654000196	ATP binding site [chemical binding]; other site
298654000197	substrate binding site [chemical binding]; other site
298654000198	activation loop (A-loop); other site
298654000199	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654000200	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654000201	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654000202	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654000203	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654000204	active site
298654000205	ATP binding site [chemical binding]; other site
298654000206	substrate binding site [chemical binding]; other site
298654000207	activation loop (A-loop); other site
298654000208	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
298654000209	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298654000210	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
298654000211	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
298654000212	Protein phosphatase 2C; Region: PP2C; pfam00481
298654000213	active site
298654000214	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654000215	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654000216	phosphopeptide binding site; other site
298654000217	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
298654000218	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654000219	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654000220	phosphopeptide binding site; other site
298654000221	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
298654000222	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654000223	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654000224	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
298654000225	active site residue [active]
298654000226	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
298654000227	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
298654000228	putative DNA binding site [nucleotide binding]; other site
298654000229	catalytic residue [active]
298654000230	putative H2TH interface [polypeptide binding]; other site
298654000231	putative catalytic residues [active]
298654000232	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
298654000233	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
298654000234	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654000235	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654000236	active site
298654000237	ATP binding site [chemical binding]; other site
298654000238	substrate binding site [chemical binding]; other site
298654000239	activation loop (A-loop); other site
298654000240	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
298654000241	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
298654000242	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
298654000243	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
298654000244	Ligand Binding Site [chemical binding]; other site
298654000245	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298654000246	DNA-binding site [nucleotide binding]; DNA binding site
298654000247	RNA-binding motif; other site
298654000248	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
298654000249	futalosine nucleosidase; Region: fut_nucase; TIGR03664
298654000250	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
298654000251	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654000252	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
298654000253	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
298654000254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000255	dimer interface [polypeptide binding]; other site
298654000256	conserved gate region; other site
298654000257	putative PBP binding loops; other site
298654000258	ABC-ATPase subunit interface; other site
298654000259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000260	dimer interface [polypeptide binding]; other site
298654000261	conserved gate region; other site
298654000262	putative PBP binding loops; other site
298654000263	ABC-ATPase subunit interface; other site
298654000264	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
298654000265	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
298654000266	Walker A/P-loop; other site
298654000267	ATP binding site [chemical binding]; other site
298654000268	Q-loop/lid; other site
298654000269	ABC transporter signature motif; other site
298654000270	Walker B; other site
298654000271	D-loop; other site
298654000272	H-loop/switch region; other site
298654000273	SEC-C motif; Region: SEC-C; pfam02810
298654000274	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
298654000275	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
298654000276	Protein of unknown function DUF111; Region: DUF111; cl03398
298654000277	Protein of unknown function DUF111; Region: DUF111; cl03398
298654000278	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
298654000279	Phosphotransferase enzyme family; Region: APH; pfam01636
298654000280	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298654000281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654000282	Coenzyme A binding pocket [chemical binding]; other site
298654000283	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
298654000284	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
298654000285	inhibitor binding site; inhibition site
298654000286	Dihydroneopterin aldolase; Region: FolB; smart00905
298654000287	active site
298654000288	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
298654000289	catalytic center binding site [active]
298654000290	ATP binding site [chemical binding]; other site
298654000291	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
298654000292	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
298654000293	WYL domain; Region: WYL; pfam13280
298654000294	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
298654000295	RibD C-terminal domain; Region: RibD_C; cl17279
298654000296	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
298654000297	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
298654000298	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654000299	ATP binding site [chemical binding]; other site
298654000300	putative Mg++ binding site [ion binding]; other site
298654000301	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654000302	nucleotide binding region [chemical binding]; other site
298654000303	ATP-binding site [chemical binding]; other site
298654000304	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
298654000305	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
298654000306	Ligand binding site; other site
298654000307	Putative Catalytic site; other site
298654000308	DXD motif; other site
298654000309	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
298654000310	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
298654000311	dimer interface [polypeptide binding]; other site
298654000312	active site
298654000313	CoA binding pocket [chemical binding]; other site
298654000314	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298654000315	putative catalytic site [active]
298654000316	putative metal binding site [ion binding]; other site
298654000317	putative phosphate binding site [ion binding]; other site
298654000318	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654000319	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
298654000320	active site
298654000321	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298654000322	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654000323	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298654000324	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
298654000325	active site
298654000326	catalytic residues [active]
298654000327	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
298654000328	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
298654000329	active site
298654000330	catalytic residues [active]
298654000331	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
298654000332	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
298654000333	active site
298654000334	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654000335	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
298654000336	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
298654000337	active site
298654000338	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
298654000339	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298654000340	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
298654000341	Scramblase; Region: Scramblase; pfam03803
298654000342	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
298654000343	putative active site [active]
298654000344	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
298654000345	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
298654000346	ring oligomerisation interface [polypeptide binding]; other site
298654000347	ATP/Mg binding site [chemical binding]; other site
298654000348	stacking interactions; other site
298654000349	hinge regions; other site
298654000350	threonine synthase; Validated; Region: PRK07591
298654000351	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
298654000352	homodimer interface [polypeptide binding]; other site
298654000353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654000354	catalytic residue [active]
298654000355	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
298654000356	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654000357	active site
298654000358	motif I; other site
298654000359	motif II; other site
298654000360	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
298654000361	active site
298654000362	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
298654000363	homotetramer interface [polypeptide binding]; other site
298654000364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654000365	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
298654000366	active site
298654000367	motif I; other site
298654000368	motif II; other site
298654000369	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
298654000370	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
298654000371	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654000372	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654000373	putative ligand binding site [chemical binding]; other site
298654000374	RNHCP domain; Region: RNHCP; pfam12647
298654000375	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
298654000376	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
298654000377	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
298654000378	NAD(P) binding site [chemical binding]; other site
298654000379	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
298654000380	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
298654000381	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
298654000382	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654000383	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
298654000384	active site
298654000385	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654000386	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
298654000387	putative active site [active]
298654000388	putative metal binding site [ion binding]; other site
298654000389	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654000390	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654000391	active site
298654000392	metal binding site [ion binding]; metal-binding site
298654000393	Clp protease ATP binding subunit; Region: clpC; CHL00095
298654000394	Clp amino terminal domain; Region: Clp_N; pfam02861
298654000395	Clp amino terminal domain; Region: Clp_N; pfam02861
298654000396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000397	Walker A motif; other site
298654000398	ATP binding site [chemical binding]; other site
298654000399	Walker B motif; other site
298654000400	arginine finger; other site
298654000401	UvrB/uvrC motif; Region: UVR; pfam02151
298654000402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000403	Walker A motif; other site
298654000404	ATP binding site [chemical binding]; other site
298654000405	Walker B motif; other site
298654000406	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
298654000407	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
298654000408	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
298654000409	dimer interface [polypeptide binding]; other site
298654000410	putative anticodon binding site; other site
298654000411	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298654000412	motif 1; other site
298654000413	dimer interface [polypeptide binding]; other site
298654000414	active site
298654000415	motif 2; other site
298654000416	motif 3; other site
298654000417	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
298654000418	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654000419	active site
298654000420	Right handed beta helix region; Region: Beta_helix; pfam13229
298654000421	Right handed beta helix region; Region: Beta_helix; pfam13229
298654000422	Alginate lyase; Region: Alginate_lyase2; pfam08787
298654000423	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
298654000424	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
298654000425	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
298654000426	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
298654000427	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
298654000428	Right handed beta helix region; Region: Beta_helix; pfam13229
298654000429	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
298654000430	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654000431	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654000432	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
298654000433	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
298654000434	active site
298654000435	catalytic triad [active]
298654000436	oxyanion hole [active]
298654000437	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
298654000438	Bacterial sugar transferase; Region: Bac_transf; pfam02397
298654000439	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
298654000440	Bacterial sugar transferase; Region: Bac_transf; pfam02397
298654000441	pantothenate kinase; Reviewed; Region: PRK13318
298654000442	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
298654000443	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
298654000444	dimerization interface [polypeptide binding]; other site
298654000445	active site
298654000446	L-aspartate oxidase; Provisional; Region: PRK07804
298654000447	L-aspartate oxidase; Provisional; Region: PRK06175
298654000448	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
298654000449	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
298654000450	pantoate--beta-alanine ligase; Region: panC; TIGR00018
298654000451	active site
298654000452	nucleotide binding site [chemical binding]; other site
298654000453	HIGH motif; other site
298654000454	KMSKS motif; other site
298654000455	MMPL family; Region: MMPL; pfam03176
298654000456	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298654000457	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
298654000458	active site
298654000459	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654000460	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654000461	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
298654000462	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
298654000463	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654000464	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654000465	putative pectinesterase; Region: PLN02432; cl01911
298654000466	Right handed beta helix region; Region: Beta_helix; pfam13229
298654000467	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
298654000468	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
298654000469	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
298654000470	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
298654000471	substrate binding site; other site
298654000472	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
298654000473	extended (e) SDRs; Region: SDR_e; cd08946
298654000474	NAD(P) binding site [chemical binding]; other site
298654000475	active site
298654000476	substrate binding site [chemical binding]; other site
298654000477	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
298654000478	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654000479	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298654000480	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
298654000481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654000482	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654000483	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298654000484	S-adenosylmethionine binding site [chemical binding]; other site
298654000485	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
298654000486	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
298654000487	nudix motif; other site
298654000488	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
298654000489	putative active site [active]
298654000490	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
298654000491	ATP binding site [chemical binding]; other site
298654000492	active site
298654000493	substrate binding site [chemical binding]; other site
298654000494	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
298654000495	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
298654000496	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
298654000497	substrate binding site; other site
298654000498	tetramer interface; other site
298654000499	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
298654000500	GDP-mannose 4,6-dehydratase; Region: PLN02653
298654000501	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
298654000502	NADP-binding site; other site
298654000503	homotetramer interface [polypeptide binding]; other site
298654000504	substrate binding site [chemical binding]; other site
298654000505	homodimer interface [polypeptide binding]; other site
298654000506	active site
298654000507	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
298654000508	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
298654000509	NADP binding site [chemical binding]; other site
298654000510	active site
298654000511	putative substrate binding site [chemical binding]; other site
298654000512	adenylosuccinate lyase; Provisional; Region: PRK07492
298654000513	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
298654000514	tetramer interface [polypeptide binding]; other site
298654000515	active site
298654000516	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
298654000517	AIR carboxylase; Region: AIRC; pfam00731
298654000518	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
298654000519	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
298654000520	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654000521	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
298654000522	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
298654000523	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
298654000524	GDP-binding site [chemical binding]; other site
298654000525	ACT binding site; other site
298654000526	IMP binding site; other site
298654000527	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
298654000528	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
298654000529	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
298654000530	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654000531	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
298654000532	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
298654000533	active site
298654000534	intersubunit interface [polypeptide binding]; other site
298654000535	zinc binding site [ion binding]; other site
298654000536	Na+ binding site [ion binding]; other site
298654000537	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298654000538	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
298654000539	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654000540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654000541	NAD(P) binding site [chemical binding]; other site
298654000542	active site
298654000543	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
298654000544	active site
298654000545	NTP binding site [chemical binding]; other site
298654000546	metal binding triad [ion binding]; metal-binding site
298654000547	MMPL family; Region: MMPL; pfam03176
298654000548	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
298654000549	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298654000550	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298654000551	4Fe-4S binding domain; Region: Fer4; pfam00037
298654000552	Cysteine-rich domain; Region: CCG; pfam02754
298654000553	Cysteine-rich domain; Region: CCG; pfam02754
298654000554	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
298654000555	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
298654000556	nucleotide binding site [chemical binding]; other site
298654000557	NEF interaction site [polypeptide binding]; other site
298654000558	SBD interface [polypeptide binding]; other site
298654000559	GrpE; Region: GrpE; pfam01025
298654000560	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
298654000561	dimer interface [polypeptide binding]; other site
298654000562	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
298654000563	chaperone protein DnaJ; Provisional; Region: PRK14295
298654000564	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298654000565	HSP70 interaction site [polypeptide binding]; other site
298654000566	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
298654000567	Zn binding sites [ion binding]; other site
298654000568	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
298654000569	dimer interface [polypeptide binding]; other site
298654000570	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
298654000571	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654000572	DNA binding residues [nucleotide binding]
298654000573	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
298654000574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000575	Walker A motif; other site
298654000576	ATP binding site [chemical binding]; other site
298654000577	Walker B motif; other site
298654000578	arginine finger; other site
298654000579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000580	Walker A motif; other site
298654000581	ATP binding site [chemical binding]; other site
298654000582	Walker B motif; other site
298654000583	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
298654000584	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
298654000585	trimer interface [polypeptide binding]; other site
298654000586	active site
298654000587	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
298654000588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654000589	motif II; other site
298654000590	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
298654000591	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
298654000592	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
298654000593	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
298654000594	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
298654000595	catalytic residues [active]
298654000596	Restriction endonuclease; Region: Mrr_cat; pfam04471
298654000597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654000598	Radical SAM superfamily; Region: Radical_SAM; pfam04055
298654000599	FeS/SAM binding site; other site
298654000600	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654000601	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654000602	non-specific DNA binding site [nucleotide binding]; other site
298654000603	salt bridge; other site
298654000604	sequence-specific DNA binding site [nucleotide binding]; other site
298654000605	Protein of unknown function (DUF419); Region: DUF419; pfam04237
298654000606	DinB superfamily; Region: DinB_2; pfam12867
298654000607	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654000608	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654000609	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654000610	Walker A/P-loop; other site
298654000611	ATP binding site [chemical binding]; other site
298654000612	Q-loop/lid; other site
298654000613	ABC transporter signature motif; other site
298654000614	Walker B; other site
298654000615	D-loop; other site
298654000616	H-loop/switch region; other site
298654000617	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
298654000618	PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353
298654000619	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
298654000620	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
298654000621	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654000622	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
298654000623	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
298654000624	putative active site [active]
298654000625	putative dimer interface [polypeptide binding]; other site
298654000626	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654000627	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654000628	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654000629	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654000630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298654000631	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654000632	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
298654000633	methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188
298654000634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654000635	S-adenosylmethionine binding site [chemical binding]; other site
298654000636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654000637	Radical SAM superfamily; Region: Radical_SAM; pfam04055
298654000638	FeS/SAM binding site; other site
298654000639	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654000640	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
298654000641	DNA binding residues [nucleotide binding]
298654000642	Clp amino terminal domain; Region: Clp_N; pfam02861
298654000643	elongation factor Tu; Reviewed; Region: PRK12736
298654000644	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
298654000645	G1 box; other site
298654000646	GEF interaction site [polypeptide binding]; other site
298654000647	GTP/Mg2+ binding site [chemical binding]; other site
298654000648	Switch I region; other site
298654000649	G2 box; other site
298654000650	G3 box; other site
298654000651	Switch II region; other site
298654000652	G4 box; other site
298654000653	G5 box; other site
298654000654	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
298654000655	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
298654000656	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
298654000657	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654000658	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
298654000659	Walker A/P-loop; other site
298654000660	ATP binding site [chemical binding]; other site
298654000661	Q-loop/lid; other site
298654000662	ABC transporter signature motif; other site
298654000663	Walker B; other site
298654000664	D-loop; other site
298654000665	H-loop/switch region; other site
298654000666	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
298654000667	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
298654000668	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654000669	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654000670	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654000671	DNA binding residues [nucleotide binding]
298654000672	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
298654000673	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
298654000674	NAD(P) binding site [chemical binding]; other site
298654000675	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
298654000676	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
298654000677	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
298654000678	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654000679	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654000680	non-specific DNA binding site [nucleotide binding]; other site
298654000681	salt bridge; other site
298654000682	sequence-specific DNA binding site [nucleotide binding]; other site
298654000683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654000684	sequence-specific DNA binding site [nucleotide binding]; other site
298654000685	salt bridge; other site
298654000686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654000687	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
298654000688	active site
298654000689	motif I; other site
298654000690	motif II; other site
298654000691	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
298654000692	homodimer interface [polypeptide binding]; other site
298654000693	putative metal binding site [ion binding]; other site
298654000694	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
298654000695	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
298654000696	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
298654000697	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
298654000698	homodecamer interface [polypeptide binding]; other site
298654000699	GTP cyclohydrolase I; Provisional; Region: PLN03044
298654000700	active site
298654000701	putative catalytic site residues [active]
298654000702	zinc binding site [ion binding]; other site
298654000703	GTP-CH-I/GFRP interaction surface; other site
298654000704	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
298654000705	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000706	Walker A motif; other site
298654000707	ATP binding site [chemical binding]; other site
298654000708	Walker B motif; other site
298654000709	arginine finger; other site
298654000710	Peptidase family M41; Region: Peptidase_M41; pfam01434
298654000711	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
298654000712	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
298654000713	Ligand Binding Site [chemical binding]; other site
298654000714	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654000715	active site
298654000716	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
298654000717	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
298654000718	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
298654000719	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
298654000720	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
298654000721	dimer interface [polypeptide binding]; other site
298654000722	substrate binding site [chemical binding]; other site
298654000723	metal binding sites [ion binding]; metal-binding site
298654000724	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654000725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654000726	active site
298654000727	phosphorylation site [posttranslational modification]
298654000728	intermolecular recognition site; other site
298654000729	dimerization interface [polypeptide binding]; other site
298654000730	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654000731	DNA binding site [nucleotide binding]
298654000732	PSP1 C-terminal conserved region; Region: PSP1; cl00770
298654000733	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
298654000734	hypothetical protein; Provisional; Region: PRK07236
298654000735	DNA polymerase III subunit delta'; Validated; Region: PRK07940
298654000736	DNA polymerase III subunit delta'; Validated; Region: PRK08485
298654000737	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654000738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654000739	putative substrate translocation pore; other site
298654000740	thymidylate kinase; Validated; Region: tmk; PRK00698
298654000741	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
298654000742	TMP-binding site; other site
298654000743	ATP-binding site [chemical binding]; other site
298654000744	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
298654000745	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
298654000746	active site
298654000747	interdomain interaction site; other site
298654000748	putative metal-binding site [ion binding]; other site
298654000749	nucleotide binding site [chemical binding]; other site
298654000750	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
298654000751	domain I; other site
298654000752	phosphate binding site [ion binding]; other site
298654000753	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
298654000754	domain II; other site
298654000755	domain III; other site
298654000756	nucleotide binding site [chemical binding]; other site
298654000757	DNA binding groove [nucleotide binding]
298654000758	catalytic site [active]
298654000759	domain IV; other site
298654000760	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
298654000761	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
298654000762	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
298654000763	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
298654000764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
298654000765	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654000766	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298654000767	anti sigma factor interaction site; other site
298654000768	regulatory phosphorylation site [posttranslational modification]; other site
298654000769	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654000770	ATP binding site [chemical binding]; other site
298654000771	putative Mg++ binding site [ion binding]; other site
298654000772	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
298654000773	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
298654000774	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
298654000775	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
298654000776	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298654000777	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
298654000778	ATP binding site [chemical binding]; other site
298654000779	Walker B motif; other site
298654000780	Fic family protein [Function unknown]; Region: COG3177
298654000781	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
298654000782	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654000783	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654000784	Colicin V production protein; Region: Colicin_V; pfam02674
298654000785	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
298654000786	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298654000787	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
298654000788	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
298654000789	putative active site [active]
298654000790	putative CoA binding site [chemical binding]; other site
298654000791	nudix motif; other site
298654000792	metal binding site [ion binding]; metal-binding site
298654000793	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
298654000794	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298654000795	minor groove reading motif; other site
298654000796	helix-hairpin-helix signature motif; other site
298654000797	substrate binding pocket [chemical binding]; other site
298654000798	active site
298654000799	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
298654000800	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298654000801	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654000802	ligand binding site [chemical binding]; other site
298654000803	flexible hinge region; other site
298654000804	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
298654000805	putative switch regulator; other site
298654000806	non-specific DNA interactions [nucleotide binding]; other site
298654000807	DNA binding site [nucleotide binding]
298654000808	sequence specific DNA binding site [nucleotide binding]; other site
298654000809	putative cAMP binding site [chemical binding]; other site
298654000810	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
298654000811	Double zinc ribbon; Region: DZR; pfam12773
298654000812	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
298654000813	cyclase homology domain; Region: CHD; cd07302
298654000814	nucleotidyl binding site; other site
298654000815	metal binding site [ion binding]; metal-binding site
298654000816	dimer interface [polypeptide binding]; other site
298654000817	AAA ATPase domain; Region: AAA_16; pfam13191
298654000818	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654000819	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
298654000820	homotrimer interaction site [polypeptide binding]; other site
298654000821	putative active site [active]
298654000822	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
298654000823	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
298654000824	DTAP/Switch II; other site
298654000825	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
298654000826	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
298654000827	P loop; other site
298654000828	Nucleotide binding site [chemical binding]; other site
298654000829	DTAP/Switch II; other site
298654000830	Switch I; other site
298654000831	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
298654000832	Transcription factor WhiB; Region: Whib; pfam02467
298654000833	Transglycosylase; Region: Transgly; pfam00912
298654000834	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
298654000835	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298654000836	Yqey-like protein; Region: YqeY; pfam09424
298654000837	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654000838	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654000839	active site
298654000840	metal binding site [ion binding]; metal-binding site
298654000841	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298654000842	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654000843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654000844	active site
298654000845	phosphorylation site [posttranslational modification]
298654000846	intermolecular recognition site; other site
298654000847	dimerization interface [polypeptide binding]; other site
298654000848	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654000849	dimerization interface [polypeptide binding]; other site
298654000850	DNA binding residues [nucleotide binding]
298654000851	Histidine kinase; Region: HisKA_3; pfam07730
298654000852	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654000853	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
298654000854	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654000855	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
298654000856	Walker A/P-loop; other site
298654000857	ATP binding site [chemical binding]; other site
298654000858	Q-loop/lid; other site
298654000859	ABC transporter signature motif; other site
298654000860	Walker B; other site
298654000861	D-loop; other site
298654000862	H-loop/switch region; other site
298654000863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654000864	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
298654000865	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654000866	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654000867	Walker A/P-loop; other site
298654000868	ATP binding site [chemical binding]; other site
298654000869	Q-loop/lid; other site
298654000870	ABC transporter signature motif; other site
298654000871	Walker B; other site
298654000872	D-loop; other site
298654000873	H-loop/switch region; other site
298654000874	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654000875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000876	putative PBP binding loops; other site
298654000877	dimer interface [polypeptide binding]; other site
298654000878	ABC-ATPase subunit interface; other site
298654000879	NMT1/THI5 like; Region: NMT1; pfam09084
298654000880	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654000881	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654000882	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654000883	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654000884	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654000885	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654000886	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654000887	active site
298654000888	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654000889	prolyl-tRNA synthetase; Provisional; Region: PRK08661
298654000890	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
298654000891	dimer interface [polypeptide binding]; other site
298654000892	motif 1; other site
298654000893	active site
298654000894	motif 2; other site
298654000895	motif 3; other site
298654000896	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
298654000897	anticodon binding site; other site
298654000898	PBP superfamily domain; Region: PBP_like_2; cl17296
298654000899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000900	putative PBP binding loops; other site
298654000901	ABC-ATPase subunit interface; other site
298654000902	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
298654000903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654000904	dimer interface [polypeptide binding]; other site
298654000905	conserved gate region; other site
298654000906	putative PBP binding loops; other site
298654000907	ABC-ATPase subunit interface; other site
298654000908	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
298654000909	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
298654000910	Walker A/P-loop; other site
298654000911	ATP binding site [chemical binding]; other site
298654000912	Q-loop/lid; other site
298654000913	ABC transporter signature motif; other site
298654000914	Walker B; other site
298654000915	D-loop; other site
298654000916	H-loop/switch region; other site
298654000917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654000918	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654000919	active site
298654000920	phosphorylation site [posttranslational modification]
298654000921	intermolecular recognition site; other site
298654000922	dimerization interface [polypeptide binding]; other site
298654000923	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654000924	DNA binding site [nucleotide binding]
298654000925	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
298654000926	metal ion-dependent adhesion site (MIDAS); other site
298654000927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654000928	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
298654000929	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
298654000930	Walker A motif; other site
298654000931	ATP binding site [chemical binding]; other site
298654000932	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
298654000933	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298654000934	minor groove reading motif; other site
298654000935	helix-hairpin-helix signature motif; other site
298654000936	active site
298654000937	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
298654000938	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
298654000939	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
298654000940	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
298654000941	DNA repair protein RadA; Provisional; Region: PRK11823
298654000942	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298654000943	Walker A motif; other site
298654000944	ATP binding site [chemical binding]; other site
298654000945	Walker B motif; other site
298654000946	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
298654000947	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
298654000948	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
298654000949	substrate binding site; other site
298654000950	dimer interface; other site
298654000951	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
298654000952	homotrimer interaction site [polypeptide binding]; other site
298654000953	zinc binding site [ion binding]; other site
298654000954	CDP-binding sites; other site
298654000955	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654000956	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
298654000957	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
298654000958	active site
298654000959	HIGH motif; other site
298654000960	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
298654000961	KMSKS motif; other site
298654000962	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
298654000963	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
298654000964	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654000965	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654000966	phosphopeptide binding site; other site
298654000967	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
298654000968	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
298654000969	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
298654000970	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
298654000971	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
298654000972	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
298654000973	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
298654000974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654000975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654000976	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654000977	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654000978	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
298654000979	Methyltransferase domain; Region: Methyltransf_31; pfam13847
298654000980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654000981	S-adenosylmethionine binding site [chemical binding]; other site
298654000982	Epoxide hydrolase N terminus; Region: EHN; pfam06441
298654000983	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654000984	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
298654000985	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
298654000986	NodB motif; other site
298654000987	active site
298654000988	catalytic site [active]
298654000989	metal binding site [ion binding]; metal-binding site
298654000990	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654000991	short chain dehydrogenase; Provisional; Region: PRK12747
298654000992	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
298654000993	NADP binding site [chemical binding]; other site
298654000994	homodimer interface [polypeptide binding]; other site
298654000995	active site
298654000996	substrate binding site [chemical binding]; other site
298654000997	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654000998	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654000999	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654001000	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
298654001001	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654001002	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654001003	YCII-related domain; Region: YCII; cl00999
298654001004	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654001005	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
298654001006	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
298654001007	ATP binding site [chemical binding]; other site
298654001008	putative Mg++ binding site [ion binding]; other site
298654001009	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654001010	nucleotide binding region [chemical binding]; other site
298654001011	ATP-binding site [chemical binding]; other site
298654001012	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654001013	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654001014	active site
298654001015	ATP binding site [chemical binding]; other site
298654001016	substrate binding site [chemical binding]; other site
298654001017	activation loop (A-loop); other site
298654001018	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
298654001019	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654001020	NB-ARC domain; Region: NB-ARC; pfam00931
298654001021	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
298654001022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654001023	TPR motif; other site
298654001024	binding surface
298654001025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654001026	binding surface
298654001027	TPR motif; other site
298654001028	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654001029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654001030	binding surface
298654001031	TPR motif; other site
298654001032	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001033	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
298654001034	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654001035	putative NAD(P) binding site [chemical binding]; other site
298654001036	PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023
298654001037	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654001038	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
298654001039	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
298654001040	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
298654001041	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
298654001042	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654001043	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298654001044	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654001045	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654001046	catalytic site [active]
298654001047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001048	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
298654001049	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654001050	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654001051	Predicted membrane protein [Function unknown]; Region: COG2261
298654001052	Hemerythrin-like domain; Region: Hr-like; cd12108
298654001053	Fe binding site [ion binding]; other site
298654001054	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654001055	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654001056	active site
298654001057	ATP binding site [chemical binding]; other site
298654001058	substrate binding site [chemical binding]; other site
298654001059	activation loop (A-loop); other site
298654001060	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654001061	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654001062	structural tetrad; other site
298654001063	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654001064	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654001065	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654001066	DNA binding residues [nucleotide binding]
298654001067	Fic/DOC family; Region: Fic; cl00960
298654001068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654001069	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654001070	putative substrate translocation pore; other site
298654001071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654001072	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654001073	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
298654001074	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654001075	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
298654001076	dimerization interface [polypeptide binding]; other site
298654001077	substrate binding pocket [chemical binding]; other site
298654001078	Protein of unknown function (DUF422); Region: DUF422; cl00991
298654001079	TSCPD domain; Region: TSCPD; cl14834
298654001080	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654001081	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
298654001082	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654001083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001085	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654001086	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654001087	putative ligand binding site [chemical binding]; other site
298654001088	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
298654001089	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654001090	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654001091	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
298654001092	generic binding surface II; other site
298654001093	generic binding surface I; other site
298654001094	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
298654001095	putative active site [active]
298654001096	putative catalytic site [active]
298654001097	putative Mg binding site IVb [ion binding]; other site
298654001098	putative DNA binding site [nucleotide binding]; other site
298654001099	putative phosphate binding site [ion binding]; other site
298654001100	putative Mg binding site IVa [ion binding]; other site
298654001101	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298654001102	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298654001103	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298654001104	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298654001105	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298654001106	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
298654001107	active site
298654001108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001110	WHG domain; Region: WHG; pfam13305
298654001111	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
298654001112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654001113	putative substrate translocation pore; other site
298654001114	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298654001115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654001116	active site
298654001117	phosphorylation site [posttranslational modification]
298654001118	intermolecular recognition site; other site
298654001119	dimerization interface [polypeptide binding]; other site
298654001120	CHASE3 domain; Region: CHASE3; pfam05227
298654001121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654001122	HAMP domain; Region: HAMP; pfam00672
298654001123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654001124	dimer interface [polypeptide binding]; other site
298654001125	phosphorylation site [posttranslational modification]
298654001126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654001127	ATP binding site [chemical binding]; other site
298654001128	Mg2+ binding site [ion binding]; other site
298654001129	G-X-G motif; other site
298654001130	Response regulator receiver domain; Region: Response_reg; pfam00072
298654001131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654001132	active site
298654001133	phosphorylation site [posttranslational modification]
298654001134	intermolecular recognition site; other site
298654001135	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654001136	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654001137	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
298654001138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654001139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654001140	Walker A/P-loop; other site
298654001141	Walker A/P-loop; other site
298654001142	ATP binding site [chemical binding]; other site
298654001143	ATP binding site [chemical binding]; other site
298654001144	Q-loop/lid; other site
298654001145	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654001146	ABC transporter signature motif; other site
298654001147	Walker B; other site
298654001148	D-loop; other site
298654001149	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654001150	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654001151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654001152	NAD(P) binding site [chemical binding]; other site
298654001153	active site
298654001154	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654001155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654001156	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
298654001157	Walker A/P-loop; other site
298654001158	ATP binding site [chemical binding]; other site
298654001159	Q-loop/lid; other site
298654001160	ABC transporter signature motif; other site
298654001161	Walker B; other site
298654001162	D-loop; other site
298654001163	H-loop/switch region; other site
298654001164	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654001165	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654001166	DNA binding site [nucleotide binding]
298654001167	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
298654001168	Bacterial transcriptional activator domain; Region: BTAD; smart01043
298654001169	Predicted ATPase [General function prediction only]; Region: COG3903
298654001170	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
298654001171	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
298654001172	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
298654001173	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
298654001174	active site
298654001175	SAM binding site [chemical binding]; other site
298654001176	homodimer interface [polypeptide binding]; other site
298654001177	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
298654001178	active site
298654001179	putative homodimer interface [polypeptide binding]; other site
298654001180	SAM binding site [chemical binding]; other site
298654001181	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
298654001182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654001183	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
298654001184	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
298654001185	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
298654001186	metal ion-dependent adhesion site (MIDAS); other site
298654001187	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
298654001188	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
298654001189	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
298654001190	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
298654001191	catalytic triad [active]
298654001192	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
298654001193	cobyric acid synthase; Provisional; Region: PRK00784
298654001194	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
298654001195	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
298654001196	catalytic triad [active]
298654001197	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
298654001198	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
298654001199	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
298654001200	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298654001201	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
298654001202	Precorrin-8X methylmutase; Region: CbiC; pfam02570
298654001203	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
298654001204	active site
298654001205	SAM binding site [chemical binding]; other site
298654001206	homodimer interface [polypeptide binding]; other site
298654001207	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
298654001208	active site
298654001209	SAM binding site [chemical binding]; other site
298654001210	homodimer interface [polypeptide binding]; other site
298654001211	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
298654001212	active site
298654001213	SAM binding site [chemical binding]; other site
298654001214	homodimer interface [polypeptide binding]; other site
298654001215	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654001216	Coenzyme A binding pocket [chemical binding]; other site
298654001217	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
298654001218	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
298654001219	DNA photolyase; Region: DNA_photolyase; pfam00875
298654001220	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
298654001221	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654001222	NAD(P) binding site [chemical binding]; other site
298654001223	active site
298654001224	GAF domain; Region: GAF; pfam01590
298654001225	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654001226	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
298654001227	dimer interface [polypeptide binding]; other site
298654001228	active site
298654001229	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
298654001230	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
298654001231	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
298654001232	active site
298654001233	TDP-binding site; other site
298654001234	acceptor substrate-binding pocket; other site
298654001235	homodimer interface [polypeptide binding]; other site
298654001236	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298654001237	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298654001238	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
298654001239	active site
298654001240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654001241	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
298654001242	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654001243	motif II; other site
298654001244	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654001245	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654001246	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654001247	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654001248	active site
298654001249	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
298654001250	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654001251	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654001252	active site
298654001253	ATP binding site [chemical binding]; other site
298654001254	substrate binding site [chemical binding]; other site
298654001255	activation loop (A-loop); other site
298654001256	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654001257	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654001258	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654001259	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654001260	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654001261	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298654001262	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654001263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654001264	Walker A motif; other site
298654001265	ATP binding site [chemical binding]; other site
298654001266	Walker B motif; other site
298654001267	arginine finger; other site
298654001268	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654001269	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654001270	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654001271	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654001272	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654001273	substrate binding site [chemical binding]; other site
298654001274	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654001275	oxyanion hole (OAH) forming residues; other site
298654001276	trimer interface [polypeptide binding]; other site
298654001277	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
298654001278	glycine dehydrogenase; Provisional; Region: PRK05367
298654001279	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654001280	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654001281	catalytic residue [active]
298654001282	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
298654001283	tetramer interface [polypeptide binding]; other site
298654001284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654001285	catalytic residue [active]
298654001286	Fic family protein [Function unknown]; Region: COG3177
298654001287	Fic/DOC family; Region: Fic; pfam02661
298654001288	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
298654001289	putative active site [active]
298654001290	putative catalytic site [active]
298654001291	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
298654001292	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654001293	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654001294	metal binding site [ion binding]; metal-binding site
298654001295	active site
298654001296	I-site; other site
298654001297	TIR domain; Region: TIR_2; pfam13676
298654001298	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
298654001299	NACHT domain; Region: NACHT; pfam05729
298654001300	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
298654001301	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
298654001302	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654001303	structural tetrad; other site
298654001304	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654001305	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654001306	structural tetrad; other site
298654001307	MMPL family; Region: MMPL; pfam03176
298654001308	MMPL family; Region: MMPL; pfam03176
298654001309	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001310	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001311	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
298654001312	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654001313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
298654001314	ATP binding site [chemical binding]; other site
298654001315	Mg2+ binding site [ion binding]; other site
298654001316	G-X-G motif; other site
298654001317	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654001318	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298654001319	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654001320	dimerization interface [polypeptide binding]; other site
298654001321	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654001322	dimerization interface [polypeptide binding]; other site
298654001323	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654001324	dimerization interface [polypeptide binding]; other site
298654001325	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654001326	dimerization interface [polypeptide binding]; other site
298654001327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654001328	dimerization interface [polypeptide binding]; other site
298654001329	GAF domain; Region: GAF_2; pfam13185
298654001330	GAF domain; Region: GAF; pfam01590
298654001331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654001332	dimer interface [polypeptide binding]; other site
298654001333	phosphorylation site [posttranslational modification]
298654001334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654001335	ATP binding site [chemical binding]; other site
298654001336	Mg2+ binding site [ion binding]; other site
298654001337	G-X-G motif; other site
298654001338	Response regulator receiver domain; Region: Response_reg; pfam00072
298654001339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654001340	active site
298654001341	phosphorylation site [posttranslational modification]
298654001342	intermolecular recognition site; other site
298654001343	dimerization interface [polypeptide binding]; other site
298654001344	Response regulator receiver domain; Region: Response_reg; pfam00072
298654001345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654001346	active site
298654001347	phosphorylation site [posttranslational modification]
298654001348	intermolecular recognition site; other site
298654001349	dimerization interface [polypeptide binding]; other site
298654001350	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
298654001351	putative homodimer interface [polypeptide binding]; other site
298654001352	putative homotetramer interface [polypeptide binding]; other site
298654001353	putative allosteric switch controlling residues; other site
298654001354	putative metal binding site [ion binding]; other site
298654001355	putative homodimer-homodimer interface [polypeptide binding]; other site
298654001356	Isochorismatase family; Region: Isochorismatase; pfam00857
298654001357	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
298654001358	catalytic triad [active]
298654001359	conserved cis-peptide bond; other site
298654001360	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
298654001361	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
298654001362	putative ligand binding site [chemical binding]; other site
298654001363	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
298654001364	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654001365	TM-ABC transporter signature motif; other site
298654001366	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
298654001367	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654001368	TM-ABC transporter signature motif; other site
298654001369	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
298654001370	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298654001371	Walker A/P-loop; other site
298654001372	ATP binding site [chemical binding]; other site
298654001373	Q-loop/lid; other site
298654001374	ABC transporter signature motif; other site
298654001375	Walker B; other site
298654001376	D-loop; other site
298654001377	H-loop/switch region; other site
298654001378	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298654001379	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654001380	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654001381	DNA-binding site [nucleotide binding]; DNA binding site
298654001382	FCD domain; Region: FCD; pfam07729
298654001383	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
298654001384	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
298654001385	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
298654001386	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
298654001387	active site
298654001388	tetramer interface; other site
298654001389	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
298654001390	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
298654001391	dimer interface [polypeptide binding]; other site
298654001392	putative functional site; other site
298654001393	putative MPT binding site; other site
298654001394	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
298654001395	trimer interface [polypeptide binding]; other site
298654001396	dimer interface [polypeptide binding]; other site
298654001397	putative active site [active]
298654001398	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
298654001399	MPT binding site; other site
298654001400	trimer interface [polypeptide binding]; other site
298654001401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654001402	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298654001403	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654001404	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654001405	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654001406	DNA binding residues [nucleotide binding]
298654001407	AAA ATPase domain; Region: AAA_16; pfam13191
298654001408	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654001409	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654001410	DNA binding residues [nucleotide binding]
298654001411	dimerization interface [polypeptide binding]; other site
298654001412	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654001413	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
298654001414	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
298654001415	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
298654001416	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
298654001417	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
298654001418	active site
298654001419	FMN binding site [chemical binding]; other site
298654001420	substrate binding site [chemical binding]; other site
298654001421	3Fe-4S cluster binding site [ion binding]; other site
298654001422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654001425	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654001426	putative substrate translocation pore; other site
298654001427	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
298654001428	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
298654001429	Cutinase; Region: Cutinase; pfam01083
298654001430	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654001431	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654001432	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654001433	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298654001434	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
298654001435	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654001436	Walker A/P-loop; other site
298654001437	ATP binding site [chemical binding]; other site
298654001438	Q-loop/lid; other site
298654001439	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
298654001440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654001441	Walker A/P-loop; other site
298654001442	ATP binding site [chemical binding]; other site
298654001443	Q-loop/lid; other site
298654001444	ABC transporter signature motif; other site
298654001445	Walker B; other site
298654001446	D-loop; other site
298654001447	H-loop/switch region; other site
298654001448	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298654001449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298654001450	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298654001451	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654001452	Cytochrome P450; Region: p450; cl12078
298654001453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001455	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654001456	Cytochrome P450; Region: p450; cl12078
298654001457	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654001458	classical (c) SDRs; Region: SDR_c; cd05233
298654001459	NAD(P) binding site [chemical binding]; other site
298654001460	active site
298654001461	Isochorismatase family; Region: Isochorismatase; pfam00857
298654001462	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
298654001463	catalytic triad [active]
298654001464	conserved cis-peptide bond; other site
298654001465	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
298654001466	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
298654001467	oligomer interface [polypeptide binding]; other site
298654001468	metal binding site [ion binding]; metal-binding site
298654001469	metal binding site [ion binding]; metal-binding site
298654001470	putative Cl binding site [ion binding]; other site
298654001471	aspartate ring; other site
298654001472	basic sphincter; other site
298654001473	hydrophobic gate; other site
298654001474	periplasmic entrance; other site
298654001475	Imelysin; Region: Peptidase_M75; pfam09375
298654001476	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
298654001477	Phosphoesterase family; Region: Phosphoesterase; pfam04185
298654001478	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654001479	FAD binding domain; Region: FAD_binding_4; pfam01565
298654001480	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654001481	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
298654001482	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
298654001483	active site
298654001484	metal binding site [ion binding]; metal-binding site
298654001485	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
298654001486	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298654001487	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
298654001488	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
298654001489	metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623
298654001490	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
298654001491	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
298654001492	substrate binding pocket [chemical binding]; other site
298654001493	active site
298654001494	iron coordination sites [ion binding]; other site
298654001495	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
298654001496	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
298654001497	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
298654001498	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654001499	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
298654001500	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
298654001501	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
298654001502	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
298654001503	NAD binding site [chemical binding]; other site
298654001504	homodimer interface [polypeptide binding]; other site
298654001505	active site
298654001506	substrate binding site [chemical binding]; other site
298654001507	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654001508	active site
298654001509	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
298654001510	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
298654001511	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654001512	NAD binding site [chemical binding]; other site
298654001513	putative substrate binding site 2 [chemical binding]; other site
298654001514	putative substrate binding site 1 [chemical binding]; other site
298654001515	active site
298654001516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
298654001517	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
298654001518	Fic family protein [Function unknown]; Region: COG3177
298654001519	Fic/DOC family; Region: Fic; pfam02661
298654001520	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
298654001521	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
298654001522	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298654001523	Cupin superfamily protein; Region: Cupin_4; pfam08007
298654001524	Cupin-like domain; Region: Cupin_8; pfam13621
298654001525	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654001526	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654001527	active site 2 [active]
298654001528	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654001529	catalytic triad [active]
298654001530	dimer interface [polypeptide binding]; other site
298654001531	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
298654001532	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
298654001533	Sulfate transporter family; Region: Sulfate_transp; pfam00916
298654001534	Domain of unknown function (DUF305); Region: DUF305; pfam03713
298654001535	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654001536	phosphopeptide binding site; other site
298654001537	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
298654001538	Ligand binding site; other site
298654001539	Putative Catalytic site; other site
298654001540	DXD motif; other site
298654001541	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
298654001542	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
298654001543	active site
298654001544	HIGH motif; other site
298654001545	dimer interface [polypeptide binding]; other site
298654001546	KMSKS motif; other site
298654001547	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
298654001548	putative active site [active]
298654001549	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654001550	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654001551	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
298654001552	active site
298654001553	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
298654001554	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
298654001555	Predicted methyltransferases [General function prediction only]; Region: COG0313
298654001556	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
298654001557	putative SAM binding site [chemical binding]; other site
298654001558	putative homodimer interface [polypeptide binding]; other site
298654001559	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
298654001560	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
298654001561	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
298654001562	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
298654001563	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654001564	active site
298654001565	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
298654001566	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
298654001567	Substrate binding site; other site
298654001568	Mg++ binding site; other site
298654001569	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
298654001570	active site
298654001571	substrate binding site [chemical binding]; other site
298654001572	CoA binding site [chemical binding]; other site
298654001573	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
298654001574	Fatty acid desaturase; Region: FA_desaturase; pfam00487
298654001575	Di-iron ligands [ion binding]; other site
298654001576	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
298654001577	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654001578	ABC transporter; Region: ABC_tran_2; pfam12848
298654001579	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654001580	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
298654001581	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
298654001582	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
298654001583	5S rRNA interface [nucleotide binding]; other site
298654001584	CTC domain interface [polypeptide binding]; other site
298654001585	L16 interface [polypeptide binding]; other site
298654001586	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
298654001587	putative active site [active]
298654001588	catalytic residue [active]
298654001589	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
298654001590	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
298654001591	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
298654001592	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
298654001593	DXD motif; other site
298654001594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654001595	active site
298654001596	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654001597	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
298654001598	active site
298654001599	catalytic residues [active]
298654001600	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
298654001601	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
298654001602	active site
298654001603	HIGH motif; other site
298654001604	dimer interface [polypeptide binding]; other site
298654001605	KMSKS motif; other site
298654001606	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298654001607	RNA binding surface [nucleotide binding]; other site
298654001608	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
298654001609	extended (e) SDRs; Region: SDR_e; cd08946
298654001610	NAD(P) binding site [chemical binding]; other site
298654001611	active site
298654001612	substrate binding site [chemical binding]; other site
298654001613	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
298654001614	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
298654001615	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654001616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654001617	S-adenosylmethionine binding site [chemical binding]; other site
298654001618	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
298654001619	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126
298654001620	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
298654001621	Chain length determinant protein; Region: Wzz; cl15801
298654001622	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
298654001623	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
298654001624	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654001625	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654001626	short chain dehydrogenase; Provisional; Region: PRK08219
298654001627	classical (c) SDRs; Region: SDR_c; cd05233
298654001628	NAD(P) binding site [chemical binding]; other site
298654001629	active site
298654001630	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
298654001631	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
298654001632	metal binding site [ion binding]; metal-binding site
298654001633	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
298654001634	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654001635	active site
298654001636	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
298654001637	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
298654001638	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654001639	ATP binding site [chemical binding]; other site
298654001640	putative Mg++ binding site [ion binding]; other site
298654001641	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654001642	nucleotide binding region [chemical binding]; other site
298654001643	ATP-binding site [chemical binding]; other site
298654001644	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
298654001645	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654001646	sequence-specific DNA binding site [nucleotide binding]; other site
298654001647	salt bridge; other site
298654001648	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654001649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654001650	non-specific DNA binding site [nucleotide binding]; other site
298654001651	salt bridge; other site
298654001652	sequence-specific DNA binding site [nucleotide binding]; other site
298654001653	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
298654001654	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
298654001655	homodimer interface [polypeptide binding]; other site
298654001656	metal binding site [ion binding]; metal-binding site
298654001657	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
298654001658	tandem repeat interface [polypeptide binding]; other site
298654001659	oligomer interface [polypeptide binding]; other site
298654001660	active site residues [active]
298654001661	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
298654001662	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
298654001663	tandem repeat interface [polypeptide binding]; other site
298654001664	oligomer interface [polypeptide binding]; other site
298654001665	active site residues [active]
298654001666	enolase; Provisional; Region: eno; PRK00077
298654001667	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
298654001668	dimer interface [polypeptide binding]; other site
298654001669	metal binding site [ion binding]; metal-binding site
298654001670	substrate binding pocket [chemical binding]; other site
298654001671	Septum formation initiator; Region: DivIC; cl17659
298654001672	Protein of unknown function (DUF501); Region: DUF501; cl00652
298654001673	exopolyphosphatase; Region: exo_poly_only; TIGR03706
298654001674	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
298654001675	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
298654001676	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
298654001677	ligand binding site [chemical binding]; other site
298654001678	active site
298654001679	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654001680	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654001681	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654001682	Bax inhibitor 1 like; Region: BaxI_1; cl17691
298654001683	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
298654001684	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654001685	active site
298654001686	catalytic triad [active]
298654001687	oxyanion hole [active]
298654001688	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
298654001689	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
298654001690	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
298654001691	metal ion-dependent adhesion site (MIDAS); other site
298654001692	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
298654001693	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
298654001694	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
298654001695	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
298654001696	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
298654001697	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
298654001698	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
298654001699	HIGH motif; other site
298654001700	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
298654001701	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654001702	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654001703	active site
298654001704	KMSKS motif; other site
298654001705	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
298654001706	tRNA binding surface [nucleotide binding]; other site
298654001707	hypothetical protein; Provisional; Region: PRK09256
298654001708	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
298654001709	active site
298654001710	substrate-binding site [chemical binding]; other site
298654001711	metal-binding site [ion binding]
298654001712	GTP binding site [chemical binding]; other site
298654001713	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
298654001714	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
298654001715	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
298654001716	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
298654001717	catalytic residues [active]
298654001718	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
298654001719	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
298654001720	putative active site [active]
298654001721	PhoH-like protein; Region: PhoH; pfam02562
298654001722	methionine sulfoxide reductase A; Provisional; Region: PRK00058
298654001723	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654001724	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654001725	active site
298654001726	ATP binding site [chemical binding]; other site
298654001727	substrate binding site [chemical binding]; other site
298654001728	activation loop (A-loop); other site
298654001729	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654001730	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654001731	structural tetrad; other site
298654001732	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
298654001733	putative active site [active]
298654001734	hypothetical protein; Provisional; Region: PRK06208
298654001735	intersubunit interface [polypeptide binding]; other site
298654001736	active site
298654001737	Zn2+ binding site [ion binding]; other site
298654001738	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
298654001739	adenylate kinase; Reviewed; Region: adk; PRK00279
298654001740	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
298654001741	AMP-binding site [chemical binding]; other site
298654001742	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
298654001743	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654001744	nudix motif; other site
298654001745	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
298654001746	putative hydrophobic ligand binding site [chemical binding]; other site
298654001747	protein interface [polypeptide binding]; other site
298654001748	gate; other site
298654001749	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
298654001750	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
298654001751	active site
298654001752	catalytic residues [active]
298654001753	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
298654001754	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654001755	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654001756	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298654001757	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
298654001758	active site
298654001759	catalytic residues [active]
298654001760	fumarate hydratase; Reviewed; Region: fumC; PRK00485
298654001761	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
298654001762	active sites [active]
298654001763	tetramer interface [polypeptide binding]; other site
298654001764	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
298654001765	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
298654001766	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
298654001767	generic binding surface II; other site
298654001768	generic binding surface I; other site
298654001769	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
298654001770	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
298654001771	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
298654001772	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
298654001773	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
298654001774	putative active site [active]
298654001775	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
298654001776	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
298654001777	Ligand binding site; other site
298654001778	Putative Catalytic site; other site
298654001779	DXD motif; other site
298654001780	RmuC family; Region: RmuC; pfam02646
298654001781	GTP-binding protein YchF; Reviewed; Region: PRK09601
298654001782	YchF GTPase; Region: YchF; cd01900
298654001783	G1 box; other site
298654001784	GTP/Mg2+ binding site [chemical binding]; other site
298654001785	Switch I region; other site
298654001786	G2 box; other site
298654001787	Switch II region; other site
298654001788	G3 box; other site
298654001789	G4 box; other site
298654001790	G5 box; other site
298654001791	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
298654001792	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654001793	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654001794	active site
298654001795	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
298654001796	active site
298654001797	8-oxo-dGMP binding site [chemical binding]; other site
298654001798	nudix motif; other site
298654001799	metal binding site [ion binding]; metal-binding site
298654001800	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
298654001801	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
298654001802	G1 box; other site
298654001803	putative GEF interaction site [polypeptide binding]; other site
298654001804	GTP/Mg2+ binding site [chemical binding]; other site
298654001805	Switch I region; other site
298654001806	G2 box; other site
298654001807	G3 box; other site
298654001808	Switch II region; other site
298654001809	G4 box; other site
298654001810	G5 box; other site
298654001811	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
298654001812	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
298654001813	UDP-glucose 4-epimerase; Region: PLN02240
298654001814	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
298654001815	NAD binding site [chemical binding]; other site
298654001816	homodimer interface [polypeptide binding]; other site
298654001817	active site
298654001818	substrate binding site [chemical binding]; other site
298654001819	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
298654001820	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
298654001821	Ferredoxin [Energy production and conversion]; Region: COG1146
298654001822	4Fe-4S binding domain; Region: Fer4; pfam00037
298654001823	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
298654001824	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654001825	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654001826	homodimer interface [polypeptide binding]; other site
298654001827	catalytic residue [active]
298654001828	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
298654001829	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
298654001830	trimer interface [polypeptide binding]; other site
298654001831	active site
298654001832	substrate binding site [chemical binding]; other site
298654001833	CoA binding site [chemical binding]; other site
298654001834	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
298654001835	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
298654001836	metal binding site [ion binding]; metal-binding site
298654001837	putative dimer interface [polypeptide binding]; other site
298654001838	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
298654001839	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
298654001840	dihydropteroate synthase; Region: DHPS; TIGR01496
298654001841	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
298654001842	substrate binding pocket [chemical binding]; other site
298654001843	dimer interface [polypeptide binding]; other site
298654001844	inhibitor binding site; inhibition site
298654001845	DivIVA domain; Region: DivI1A_domain; TIGR03544
298654001846	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
298654001847	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
298654001848	interface (dimer of trimers) [polypeptide binding]; other site
298654001849	Substrate-binding/catalytic site; other site
298654001850	Zn-binding sites [ion binding]; other site
298654001851	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
298654001852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654001853	S-adenosylmethionine binding site [chemical binding]; other site
298654001854	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
298654001855	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654001856	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654001857	DNA binding residues [nucleotide binding]
298654001858	Putative zinc-finger; Region: zf-HC2; pfam13490
298654001859	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
298654001860	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298654001861	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298654001862	sec-independent translocase; Provisional; Region: PRK01371
298654001863	MarR family; Region: MarR; pfam01047
298654001864	Domain of unknown function DUF59; Region: DUF59; cl00941
298654001865	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
298654001866	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
298654001867	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
298654001868	putative active site [active]
298654001869	putative catalytic site [active]
298654001870	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
298654001871	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
298654001872	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654001873	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654001874	putative metal binding site [ion binding]; other site
298654001875	Tellurium resistance protein; Region: Tellurium_res; pfam10138
298654001876	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654001877	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654001878	putative metal binding site [ion binding]; other site
298654001879	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
298654001880	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
298654001881	active site
298654001882	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
298654001883	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654001884	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654001885	active site
298654001886	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
298654001887	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
298654001888	MgtE intracellular N domain; Region: MgtE_N; smart00924
298654001889	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
298654001890	hypothetical protein; Provisional; Region: PRK07857
298654001891	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
298654001892	aminotransferase family protein; Provisional; Region: PLN00175
298654001893	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654001894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654001895	homodimer interface [polypeptide binding]; other site
298654001896	catalytic residue [active]
298654001897	Right handed beta helix region; Region: Beta_helix; pfam13229
298654001898	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298654001899	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654001900	P-loop; other site
298654001901	Magnesium ion binding site [ion binding]; other site
298654001902	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654001903	Magnesium ion binding site [ion binding]; other site
298654001904	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298654001905	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298654001906	ATP binding site [chemical binding]; other site
298654001907	Mg++ binding site [ion binding]; other site
298654001908	motif III; other site
298654001909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654001910	nucleotide binding region [chemical binding]; other site
298654001911	ATP-binding site [chemical binding]; other site
298654001912	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
298654001913	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
298654001914	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001915	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001916	LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861
298654001917	nucleotide binding site [chemical binding]; other site
298654001918	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
298654001919	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
298654001920	putative DNA binding site [nucleotide binding]; other site
298654001921	putative homodimer interface [polypeptide binding]; other site
298654001922	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
298654001923	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
298654001924	ATP binding site [chemical binding]; other site
298654001925	substrate interface [chemical binding]; other site
298654001926	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
298654001927	active site residue [active]
298654001928	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
298654001929	DNA binding site [nucleotide binding]
298654001930	active site
298654001931	classical (c) SDRs; Region: SDR_c; cd05233
298654001932	NAD(P) binding site [chemical binding]; other site
298654001933	active site
298654001934	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
298654001935	Part of AAA domain; Region: AAA_19; pfam13245
298654001936	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
298654001937	Family description; Region: UvrD_C_2; pfam13538
298654001938	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
298654001939	Part of AAA domain; Region: AAA_19; pfam13245
298654001940	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
298654001941	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
298654001942	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298654001943	putative catalytic site [active]
298654001944	putative metal binding site [ion binding]; other site
298654001945	putative phosphate binding site [ion binding]; other site
298654001946	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
298654001947	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
298654001948	active site
298654001949	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298654001950	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298654001951	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298654001952	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298654001953	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298654001954	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298654001955	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
298654001956	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
298654001957	catalytic residues [active]
298654001958	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
298654001959	Family description; Region: UvrD_C_2; pfam13538
298654001960	HRDC domain; Region: HRDC; pfam00570
298654001961	Transcription factor WhiB; Region: Whib; pfam02467
298654001962	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
298654001963	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
298654001964	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
298654001965	ABC1 family; Region: ABC1; pfam03109
298654001966	serine/threonine protein kinase; Provisional; Region: PRK14879
298654001967	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
298654001968	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
298654001969	MoaE homodimer interface [polypeptide binding]; other site
298654001970	MoaD interaction [polypeptide binding]; other site
298654001971	active site residues [active]
298654001972	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
298654001973	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654001974	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298654001975	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
298654001976	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
298654001977	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
298654001978	tyramine oxidase; Provisional; Region: tynA; PRK11504
298654001979	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
298654001980	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
298654001981	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
298654001982	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654001983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654001984	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
298654001985	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
298654001986	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654001987	inhibitor-cofactor binding pocket; inhibition site
298654001988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654001989	catalytic residue [active]
298654001990	dimerization interface [polypeptide binding]; other site
298654001991	putative DNA binding site [nucleotide binding]; other site
298654001992	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298654001993	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
298654001994	putative Zn2+ binding site [ion binding]; other site
298654001995	AsnC family; Region: AsnC_trans_reg; pfam01037
298654001996	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
298654001997	FAD dependent oxidoreductase; Region: DAO; pfam01266
298654001998	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
298654001999	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
298654002000	tetrameric interface [polypeptide binding]; other site
298654002001	NAD binding site [chemical binding]; other site
298654002002	catalytic residues [active]
298654002003	substrate binding site [chemical binding]; other site
298654002004	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654002005	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
298654002006	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
298654002007	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
298654002008	active site
298654002009	catalytic site [active]
298654002010	metal binding site [ion binding]; metal-binding site
298654002011	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
298654002012	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
298654002013	active site
298654002014	ribosome small subunit-dependent GTPase A; Region: TIGR00157
298654002015	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
298654002016	GTPase/Zn-binding domain interface [polypeptide binding]; other site
298654002017	GTP/Mg2+ binding site [chemical binding]; other site
298654002018	G4 box; other site
298654002019	G5 box; other site
298654002020	G1 box; other site
298654002021	Switch I region; other site
298654002022	G2 box; other site
298654002023	G3 box; other site
298654002024	Switch II region; other site
298654002025	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
298654002026	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
298654002027	hinge; other site
298654002028	active site
298654002029	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654002030	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298654002031	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
298654002032	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654002033	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654002034	DNA binding residues [nucleotide binding]
298654002035	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
298654002036	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654002037	carboxyltransferase (CT) interaction site; other site
298654002038	biotinylation site [posttranslational modification]; other site
298654002039	biotin synthase; Validated; Region: PRK06256
298654002040	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654002041	FeS/SAM binding site; other site
298654002042	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
298654002043	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
298654002044	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
298654002045	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654002046	catalytic residue [active]
298654002047	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654002048	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
298654002049	PAS domain; Region: PAS_9; pfam13426
298654002050	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
298654002051	Histidine kinase; Region: HisKA_2; pfam07568
298654002052	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654002053	ATP binding site [chemical binding]; other site
298654002054	Mg2+ binding site [ion binding]; other site
298654002055	G-X-G motif; other site
298654002056	Transcription factor WhiB; Region: Whib; pfam02467
298654002057	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
298654002058	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
298654002059	active site
298654002060	catalytic site [active]
298654002061	metal binding site [ion binding]; metal-binding site
298654002062	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
298654002063	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
298654002064	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
298654002065	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654002066	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298654002067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
298654002068	DNA binding residues [nucleotide binding]
298654002069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
298654002070	Protein of unknown function, DUF462; Region: DUF462; cl01190
298654002071	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654002072	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
298654002073	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
298654002074	Catalytic site [active]
298654002075	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
298654002076	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298654002077	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
298654002078	Walker A/P-loop; other site
298654002079	ATP binding site [chemical binding]; other site
298654002080	Q-loop/lid; other site
298654002081	ABC transporter signature motif; other site
298654002082	Walker B; other site
298654002083	D-loop; other site
298654002084	H-loop/switch region; other site
298654002085	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298654002086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654002087	dimer interface [polypeptide binding]; other site
298654002088	conserved gate region; other site
298654002089	putative PBP binding loops; other site
298654002090	ABC-ATPase subunit interface; other site
298654002091	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298654002092	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298654002093	substrate binding pocket [chemical binding]; other site
298654002094	membrane-bound complex binding site; other site
298654002095	hinge residues; other site
298654002096	Malic enzyme, N-terminal domain; Region: malic; pfam00390
298654002097	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
298654002098	NAD(P) binding pocket [chemical binding]; other site
298654002099	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654002100	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654002101	NAD(P) binding site [chemical binding]; other site
298654002102	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
298654002103	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298654002104	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
298654002105	TPP-binding site [chemical binding]; other site
298654002106	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
298654002107	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
298654002108	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
298654002109	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
298654002110	thiamine monophosphate kinase; Provisional; Region: PRK05731
298654002111	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
298654002112	ATP binding site [chemical binding]; other site
298654002113	dimerization interface [polypeptide binding]; other site
298654002114	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
298654002115	Part of AAA domain; Region: AAA_19; pfam13245
298654002116	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
298654002117	AAA domain; Region: AAA_12; pfam13087
298654002118	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
298654002119	putative active site [active]
298654002120	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
298654002121	Part of AAA domain; Region: AAA_19; pfam13245
298654002122	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
298654002123	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
298654002124	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654002125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654002126	S-adenosylmethionine binding site [chemical binding]; other site
298654002127	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317
298654002128	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654002129	metal binding site [ion binding]; metal-binding site
298654002130	active site
298654002131	I-site; other site
298654002132	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654002133	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654002134	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
298654002135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654002136	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654002137	putative substrate translocation pore; other site
298654002138	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654002139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654002140	active site
298654002141	phosphorylation site [posttranslational modification]
298654002142	intermolecular recognition site; other site
298654002143	dimerization interface [polypeptide binding]; other site
298654002144	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654002145	DNA binding site [nucleotide binding]
298654002146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654002147	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654002148	dimerization interface [polypeptide binding]; other site
298654002149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654002150	dimer interface [polypeptide binding]; other site
298654002151	phosphorylation site [posttranslational modification]
298654002152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654002153	Mg2+ binding site [ion binding]; other site
298654002154	G-X-G motif; other site
298654002155	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
298654002156	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
298654002157	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
298654002158	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
298654002159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654002160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380
298654002161	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654002162	AAA domain; Region: AAA_23; pfam13476
298654002163	Walker A/P-loop; other site
298654002164	ATP binding site [chemical binding]; other site
298654002165	Q-loop/lid; other site
298654002166	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
298654002167	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654002168	ABC transporter signature motif; other site
298654002169	Walker B; other site
298654002170	D-loop; other site
298654002171	H-loop/switch region; other site
298654002172	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
298654002173	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
298654002174	active site
298654002175	metal binding site [ion binding]; metal-binding site
298654002176	DNA binding site [nucleotide binding]
298654002177	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
298654002178	HerA helicase [Replication, recombination, and repair]; Region: COG0433
298654002179	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654002180	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
298654002181	active site
298654002182	putative substrate binding pocket [chemical binding]; other site
298654002183	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654002184	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
298654002185	NodB motif; other site
298654002186	active site
298654002187	catalytic site [active]
298654002188	metal binding site [ion binding]; metal-binding site
298654002189	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654002190	Transcriptional regulator PadR-like family; Region: PadR; cl17335
298654002191	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654002192	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654002193	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
298654002194	dimer interface [polypeptide binding]; other site
298654002195	decamer (pentamer of dimers) interface [polypeptide binding]; other site
298654002196	catalytic triad [active]
298654002197	Bacterial transcriptional activator domain; Region: BTAD; smart01043
298654002198	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
298654002199	heme-binding site [chemical binding]; other site
298654002200	Predicted transcriptional regulator [Transcription]; Region: COG2345
298654002201	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654002202	putative DNA binding site [nucleotide binding]; other site
298654002203	Replication-relaxation; Region: Replic_Relax; pfam13814
298654002204	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
298654002205	TIR domain; Region: TIR_2; pfam13676
298654002206	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654002207	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654002208	structural tetrad; other site
298654002209	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654002210	structural tetrad; other site
298654002211	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654002212	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654002213	structural tetrad; other site
298654002214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654002215	S-adenosylmethionine binding site [chemical binding]; other site
298654002216	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
298654002217	putative hydrophobic ligand binding site [chemical binding]; other site
298654002218	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654002219	dimerization interface [polypeptide binding]; other site
298654002220	putative DNA binding site [nucleotide binding]; other site
298654002221	putative Zn2+ binding site [ion binding]; other site
298654002222	TIGR03086 family protein; Region: TIGR03086
298654002223	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654002224	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298654002225	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
298654002226	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
298654002227	nudix motif; other site
298654002228	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
298654002229	sequence-specific DNA binding site [nucleotide binding]; other site
298654002230	salt bridge; other site
298654002231	Resolvase, N terminal domain; Region: Resolvase; smart00857
298654002232	catalytic residues [active]
298654002233	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654002234	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
298654002235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654002236	S-adenosylmethionine binding site [chemical binding]; other site
298654002237	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
298654002238	active site
298654002239	zinc binding site [ion binding]; other site
298654002240	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
298654002241	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
298654002242	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654002243	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654002244	SpaB C-terminal domain; Region: SpaB_C; pfam14028
298654002245	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654002246	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
298654002247	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
298654002248	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
298654002249	Uncharacterized conserved protein [Function unknown]; Region: COG2353
298654002250	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654002251	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654002252	classical (c) SDRs; Region: SDR_c; cd05233
298654002253	NAD(P) binding site [chemical binding]; other site
298654002254	active site
298654002255	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654002256	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654002257	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654002258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654002259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654002260	non-specific DNA binding site [nucleotide binding]; other site
298654002261	salt bridge; other site
298654002262	sequence-specific DNA binding site [nucleotide binding]; other site
298654002263	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654002264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654002265	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654002266	active site
298654002267	phosphorylation site [posttranslational modification]
298654002268	intermolecular recognition site; other site
298654002269	dimerization interface [polypeptide binding]; other site
298654002270	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654002271	DNA binding residues [nucleotide binding]
298654002272	dimerization interface [polypeptide binding]; other site
298654002273	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654002274	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654002275	DNA binding residues [nucleotide binding]
298654002276	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
298654002277	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
298654002278	putative dimer interface [polypeptide binding]; other site
298654002279	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654002280	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
298654002281	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
298654002282	catalytic residues [active]
298654002283	catalytic nucleophile [active]
298654002284	Recombinase; Region: Recombinase; pfam07508
298654002285	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
298654002286	Response regulator receiver domain; Region: Response_reg; pfam00072
298654002287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654002288	active site
298654002289	phosphorylation site [posttranslational modification]
298654002290	intermolecular recognition site; other site
298654002291	dimerization interface [polypeptide binding]; other site
298654002292	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
298654002293	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
298654002294	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
298654002295	active site
298654002296	HIGH motif; other site
298654002297	KMSK motif region; other site
298654002298	DALR anticodon binding domain; Region: DALR_1; smart00836
298654002299	anticodon binding site; other site
298654002300	tRNA binding surface [nucleotide binding]; other site
298654002301	diaminopimelate decarboxylase; Region: lysA; TIGR01048
298654002302	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
298654002303	active site
298654002304	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298654002305	substrate binding site [chemical binding]; other site
298654002306	catalytic residues [active]
298654002307	dimer interface [polypeptide binding]; other site
298654002308	homoserine dehydrogenase; Provisional; Region: PRK06349
298654002309	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
298654002310	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
298654002311	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
298654002312	threonine synthase; Reviewed; Region: PRK06721
298654002313	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
298654002314	homodimer interface [polypeptide binding]; other site
298654002315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654002316	catalytic residue [active]
298654002317	homoserine kinase; Provisional; Region: PRK01212
298654002318	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
298654002319	transcription termination factor Rho; Provisional; Region: PRK12608
298654002320	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
298654002321	RNA binding site [nucleotide binding]; other site
298654002322	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
298654002323	multimer interface [polypeptide binding]; other site
298654002324	Walker A motif; other site
298654002325	ATP binding site [chemical binding]; other site
298654002326	Walker B motif; other site
298654002327	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
298654002328	peptide chain release factor 1; Validated; Region: prfA; PRK00591
298654002329	This domain is found in peptide chain release factors; Region: PCRF; smart00937
298654002330	RF-1 domain; Region: RF-1; pfam00472
298654002331	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
298654002332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654002333	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
298654002334	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
298654002335	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
298654002336	Mg++ binding site [ion binding]; other site
298654002337	putative catalytic motif [active]
298654002338	substrate binding site [chemical binding]; other site
298654002339	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
298654002340	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
298654002341	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
298654002342	ATP synthase subunit C; Region: ATP-synt_C; cl00466
298654002343	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
298654002344	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
298654002345	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
298654002346	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
298654002347	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
298654002348	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
298654002349	beta subunit interaction interface [polypeptide binding]; other site
298654002350	Walker A motif; other site
298654002351	ATP binding site [chemical binding]; other site
298654002352	Walker B motif; other site
298654002353	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
298654002354	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
298654002355	core domain interface [polypeptide binding]; other site
298654002356	delta subunit interface [polypeptide binding]; other site
298654002357	epsilon subunit interface [polypeptide binding]; other site
298654002358	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
298654002359	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
298654002360	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
298654002361	alpha subunit interaction interface [polypeptide binding]; other site
298654002362	Walker A motif; other site
298654002363	ATP binding site [chemical binding]; other site
298654002364	Walker B motif; other site
298654002365	inhibitor binding site; inhibition site
298654002366	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
298654002367	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
298654002368	gamma subunit interface [polypeptide binding]; other site
298654002369	epsilon subunit interface [polypeptide binding]; other site
298654002370	LBP interface [polypeptide binding]; other site
298654002371	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
298654002372	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654002373	nudix motif; other site
298654002374	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
298654002375	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
298654002376	B12 binding site [chemical binding]; other site
298654002377	cobalt ligand [ion binding]; other site
298654002378	hypothetical protein; Provisional; Region: PRK03298
298654002379	HD domain; Region: HD_4; pfam13328
298654002380	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
298654002381	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
298654002382	hinge; other site
298654002383	active site
298654002384	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
298654002385	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654002386	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654002387	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
298654002388	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654002389	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654002390	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
298654002391	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
298654002392	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654002393	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
298654002394	NAD(P) binding site [chemical binding]; other site
298654002395	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654002396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654002397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654002398	DNA binding residues [nucleotide binding]
298654002399	Family description; Region: VCBS; pfam13517
298654002400	putative acyltransferase; Provisional; Region: PRK05790
298654002401	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654002402	dimer interface [polypeptide binding]; other site
298654002403	active site
298654002404	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
298654002405	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
298654002406	Walker A; other site
298654002407	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
298654002408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654002409	dimer interface [polypeptide binding]; other site
298654002410	phosphorylation site [posttranslational modification]
298654002411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654002412	ATP binding site [chemical binding]; other site
298654002413	Mg2+ binding site [ion binding]; other site
298654002414	G-X-G motif; other site
298654002415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654002416	Response regulator receiver domain; Region: Response_reg; pfam00072
298654002417	active site
298654002418	phosphorylation site [posttranslational modification]
298654002419	intermolecular recognition site; other site
298654002420	dimerization interface [polypeptide binding]; other site
298654002421	Domain of unknown function DUF77; Region: DUF77; pfam01910
298654002422	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
298654002423	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
298654002424	glycogen branching enzyme; Provisional; Region: PRK05402
298654002425	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
298654002426	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
298654002427	active site
298654002428	catalytic site [active]
298654002429	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
298654002430	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
298654002431	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
298654002432	trehalose synthase; Region: treS_nterm; TIGR02456
298654002433	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
298654002434	active site
298654002435	catalytic site [active]
298654002436	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
298654002437	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
298654002438	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
298654002439	active site
298654002440	homodimer interface [polypeptide binding]; other site
298654002441	catalytic site [active]
298654002442	acceptor binding site [chemical binding]; other site
298654002443	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654002444	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654002445	putative metal binding site [ion binding]; other site
298654002446	hypothetical protein; Provisional; Region: PRK14013
298654002447	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
298654002448	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654002449	putative metal binding site [ion binding]; other site
298654002450	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
298654002451	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
298654002452	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
298654002453	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654002454	nucleotide binding site [chemical binding]; other site
298654002455	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654002456	SBD interface [polypeptide binding]; other site
298654002457	Double zinc ribbon; Region: DZR; pfam12773
298654002458	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
298654002459	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
298654002460	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
298654002461	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654002462	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654002463	active site
298654002464	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654002465	acetyl-CoA synthetase; Provisional; Region: PRK00174
298654002466	acyl-activating enzyme (AAE) consensus motif; other site
298654002467	AMP binding site [chemical binding]; other site
298654002468	active site
298654002469	CoA binding site [chemical binding]; other site
298654002470	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
298654002471	putative homodimer interface [polypeptide binding]; other site
298654002472	putative active site pocket [active]
298654002473	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
298654002474	Pirin-related protein [General function prediction only]; Region: COG1741
298654002475	Pirin; Region: Pirin; pfam02678
298654002476	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
298654002477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654002478	enoyl-CoA hydratase; Provisional; Region: PRK05862
298654002479	substrate binding site [chemical binding]; other site
298654002480	oxyanion hole (OAH) forming residues; other site
298654002481	trimer interface [polypeptide binding]; other site
298654002482	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
298654002483	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
298654002484	active site
298654002485	catalytic site [active]
298654002486	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298654002487	putative catalytic site [active]
298654002488	putative metal binding site [ion binding]; other site
298654002489	putative phosphate binding site [ion binding]; other site
298654002490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654002491	TPR motif; other site
298654002492	binding surface
298654002493	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
298654002494	Ligand binding site [chemical binding]; other site
298654002495	Electron transfer flavoprotein domain; Region: ETF; pfam01012
298654002496	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
298654002497	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
298654002498	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
298654002499	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654002500	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654002501	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298654002502	RNA binding surface [nucleotide binding]; other site
298654002503	classical (c) SDRs; Region: SDR_c; cd05233
298654002504	NAD(P) binding site [chemical binding]; other site
298654002505	active site
298654002506	Creatinine amidohydrolase; Region: Creatininase; cl00618
298654002507	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
298654002508	B12 binding site [chemical binding]; other site
298654002509	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
298654002510	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298654002511	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
298654002512	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654002513	MarR family; Region: MarR; pfam01047
298654002514	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
298654002515	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654002516	FeS/SAM binding site; other site
298654002517	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
298654002518	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
298654002519	mycofactocin precursor; Region: mycofactocin; TIGR03969
298654002520	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654002521	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
298654002522	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
298654002523	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654002524	catalytic residue [active]
298654002525	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
298654002526	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
298654002527	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
298654002528	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
298654002529	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
298654002530	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
298654002531	nucleotide binding pocket [chemical binding]; other site
298654002532	K-X-D-G motif; other site
298654002533	catalytic site [active]
298654002534	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
298654002535	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
298654002536	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
298654002537	Dimer interface [polypeptide binding]; other site
298654002538	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
298654002539	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
298654002540	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
298654002541	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
298654002542	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
298654002543	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
298654002544	GatB domain; Region: GatB_Yqey; smart00845
298654002545	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
298654002546	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298654002547	Walker A/P-loop; other site
298654002548	ATP binding site [chemical binding]; other site
298654002549	Q-loop/lid; other site
298654002550	ABC transporter signature motif; other site
298654002551	Walker B; other site
298654002552	D-loop; other site
298654002553	H-loop/switch region; other site
298654002554	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654002555	DNA-binding site [nucleotide binding]; DNA binding site
298654002556	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654002557	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654002558	active site
298654002559	metal binding site [ion binding]; metal-binding site
298654002560	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298654002561	Septum formation; Region: Septum_form; pfam13845
298654002562	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
298654002563	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
298654002564	ligand binding site [chemical binding]; other site
298654002565	NAD binding site [chemical binding]; other site
298654002566	dimerization interface [polypeptide binding]; other site
298654002567	catalytic site [active]
298654002568	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
298654002569	putative L-serine binding site [chemical binding]; other site
298654002570	ketol-acid reductoisomerase; Provisional; Region: PRK05479
298654002571	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
298654002572	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
298654002573	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
298654002574	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
298654002575	putative valine binding site [chemical binding]; other site
298654002576	dimer interface [polypeptide binding]; other site
298654002577	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
298654002578	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
298654002579	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298654002580	PYR/PP interface [polypeptide binding]; other site
298654002581	dimer interface [polypeptide binding]; other site
298654002582	TPP binding site [chemical binding]; other site
298654002583	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298654002584	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
298654002585	TPP-binding site [chemical binding]; other site
298654002586	dimer interface [polypeptide binding]; other site
298654002587	2-isopropylmalate synthase; Validated; Region: PRK03739
298654002588	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
298654002589	active site
298654002590	catalytic residues [active]
298654002591	metal binding site [ion binding]; metal-binding site
298654002592	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
298654002593	NACHT domain; Region: NACHT; pfam05729
298654002594	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
298654002595	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
298654002596	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
298654002597	homodimer interface [polypeptide binding]; other site
298654002598	substrate-cofactor binding pocket; other site
298654002599	catalytic residue [active]
298654002600	FOG: CBS domain [General function prediction only]; Region: COG0517
298654002601	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624
298654002602	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
298654002603	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654002604	ligand binding site [chemical binding]; other site
298654002605	flexible hinge region; other site
298654002606	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
298654002607	putative switch regulator; other site
298654002608	non-specific DNA interactions [nucleotide binding]; other site
298654002609	DNA binding site [nucleotide binding]
298654002610	sequence specific DNA binding site [nucleotide binding]; other site
298654002611	putative cAMP binding site [chemical binding]; other site
298654002612	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
298654002613	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
298654002614	active site
298654002615	catalytic residues [active]
298654002616	metal binding site [ion binding]; metal-binding site
298654002617	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
298654002618	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
298654002619	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
298654002620	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
298654002621	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654002622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654002623	dimer interface [polypeptide binding]; other site
298654002624	phosphorylation site [posttranslational modification]
298654002625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654002626	ATP binding site [chemical binding]; other site
298654002627	Mg2+ binding site [ion binding]; other site
298654002628	G-X-G motif; other site
298654002629	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654002630	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298654002631	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654002632	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654002633	active site
298654002634	ATP binding site [chemical binding]; other site
298654002635	substrate binding site [chemical binding]; other site
298654002636	activation loop (A-loop); other site
298654002637	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654002638	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654002639	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654002640	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654002641	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654002642	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
298654002643	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
298654002644	substrate binding site [chemical binding]; other site
298654002645	ligand binding site [chemical binding]; other site
298654002646	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
298654002647	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
298654002648	substrate binding site [chemical binding]; other site
298654002649	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
298654002650	IHF - DNA interface [nucleotide binding]; other site
298654002651	IHF dimer interface [polypeptide binding]; other site
298654002652	polyphosphate kinase; Provisional; Region: PRK05443
298654002653	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
298654002654	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
298654002655	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
298654002656	putative domain interface [polypeptide binding]; other site
298654002657	putative active site [active]
298654002658	catalytic site [active]
298654002659	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
298654002660	putative active site [active]
298654002661	catalytic site [active]
298654002662	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654002663	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
298654002664	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654002665	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654002666	Putative cyclase; Region: Cyclase; cl00814
298654002667	Guanylyl transferase CofC like; Region: CofC; cl17472
298654002668	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
298654002669	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
298654002670	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
298654002671	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
298654002672	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
298654002673	hinge; other site
298654002674	active site
298654002675	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
298654002676	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
298654002677	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
298654002678	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
298654002679	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298654002680	AsnC family; Region: AsnC_trans_reg; pfam01037
298654002681	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
298654002682	dimer interface [polypeptide binding]; other site
298654002683	substrate binding site [chemical binding]; other site
298654002684	ATP binding site [chemical binding]; other site
298654002685	SCP-2 sterol transfer family; Region: SCP2; pfam02036
298654002686	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
298654002687	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
298654002688	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
298654002689	generic binding surface II; other site
298654002690	ssDNA binding site; other site
298654002691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654002692	ATP binding site [chemical binding]; other site
298654002693	putative Mg++ binding site [ion binding]; other site
298654002694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654002695	ATP-binding site [chemical binding]; other site
298654002696	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
298654002697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654002698	S-adenosylmethionine binding site [chemical binding]; other site
298654002699	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
298654002700	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
298654002701	active site
298654002702	(T/H)XGH motif; other site
298654002703	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
298654002704	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
298654002705	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
298654002706	ribonuclease III; Reviewed; Region: rnc; PRK00102
298654002707	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
298654002708	dimerization interface [polypeptide binding]; other site
298654002709	active site
298654002710	metal binding site [ion binding]; metal-binding site
298654002711	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
298654002712	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
298654002713	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
298654002714	DNA binding site [nucleotide binding]
298654002715	putative catalytic residues [active]
298654002716	turnover-facilitating residue; other site
298654002717	intercalation triad [nucleotide binding]; other site
298654002718	8OG recognition residue [nucleotide binding]; other site
298654002719	putative reading head residues; other site
298654002720	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
298654002721	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
298654002722	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
298654002723	Acylphosphatase; Region: Acylphosphatase; cl00551
298654002724	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
298654002725	Walker A/P-loop; other site
298654002726	ATP binding site [chemical binding]; other site
298654002727	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
298654002728	ABC transporter signature motif; other site
298654002729	Walker B; other site
298654002730	D-loop; other site
298654002731	H-loop/switch region; other site
298654002732	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
298654002733	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
298654002734	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298654002735	signal recognition particle protein; Provisional; Region: PRK10867
298654002736	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
298654002737	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
298654002738	GTP binding site [chemical binding]; other site
298654002739	Signal peptide binding domain; Region: SRP_SPB; pfam02978
298654002740	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
298654002741	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
298654002742	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
298654002743	RimM N-terminal domain; Region: RimM; pfam01782
298654002744	PRC-barrel domain; Region: PRC; pfam05239
298654002745	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
298654002746	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
298654002747	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
298654002748	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
298654002749	Catalytic site [active]
298654002750	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
298654002751	RNA/DNA hybrid binding site [nucleotide binding]; other site
298654002752	active site
298654002753	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
298654002754	hypothetical protein; Reviewed; Region: PRK12497
298654002755	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
298654002756	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
298654002757	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
298654002758	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
298654002759	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
298654002760	DNA protecting protein DprA; Region: dprA; TIGR00732
298654002761	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
298654002762	Peptidase family M23; Region: Peptidase_M23; pfam01551
298654002763	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
298654002764	rRNA interaction site [nucleotide binding]; other site
298654002765	S8 interaction site; other site
298654002766	putative laminin-1 binding site; other site
298654002767	elongation factor Ts; Reviewed; Region: tsf; PRK12332
298654002768	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
298654002769	Elongation factor TS; Region: EF_TS; pfam00889
298654002770	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
298654002771	putative nucleotide binding site [chemical binding]; other site
298654002772	uridine monophosphate binding site [chemical binding]; other site
298654002773	homohexameric interface [polypeptide binding]; other site
298654002774	ribosome recycling factor; Reviewed; Region: frr; PRK00083
298654002775	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
298654002776	hinge region; other site
298654002777	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
298654002778	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
298654002779	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
298654002780	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654002781	FeS/SAM binding site; other site
298654002782	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
298654002783	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
298654002784	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
298654002785	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
298654002786	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
298654002787	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
298654002788	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
298654002789	active site
298654002790	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
298654002791	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
298654002792	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
298654002793	putative substrate binding region [chemical binding]; other site
298654002794	putative substrate binding region [chemical binding]; other site
298654002795	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
298654002796	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
298654002797	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
298654002798	Predicted acetyltransferase [General function prediction only]; Region: COG3393
298654002799	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
298654002800	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654002801	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654002802	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
298654002803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654002804	dimer interface [polypeptide binding]; other site
298654002805	conserved gate region; other site
298654002806	putative PBP binding loops; other site
298654002807	ABC-ATPase subunit interface; other site
298654002808	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
298654002809	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654002810	dimer interface [polypeptide binding]; other site
298654002811	conserved gate region; other site
298654002812	putative PBP binding loops; other site
298654002813	ABC-ATPase subunit interface; other site
298654002814	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
298654002815	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
298654002816	Walker A/P-loop; other site
298654002817	ATP binding site [chemical binding]; other site
298654002818	Q-loop/lid; other site
298654002819	ABC transporter signature motif; other site
298654002820	Walker B; other site
298654002821	D-loop; other site
298654002822	H-loop/switch region; other site
298654002823	Predicted transcriptional regulator [Transcription]; Region: COG1959
298654002824	Transcriptional regulator; Region: Rrf2; pfam02082
298654002825	ribosome maturation protein RimP; Reviewed; Region: PRK00092
298654002826	Sm and related proteins; Region: Sm_like; cl00259
298654002827	heptamer interface [polypeptide binding]; other site
298654002828	Sm1 motif; other site
298654002829	hexamer interface [polypeptide binding]; other site
298654002830	RNA binding site [nucleotide binding]; other site
298654002831	Sm2 motif; other site
298654002832	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
298654002833	NusA N-terminal domain; Region: NusA_N; pfam08529
298654002834	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
298654002835	RNA binding site [nucleotide binding]; other site
298654002836	homodimer interface [polypeptide binding]; other site
298654002837	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
298654002838	G-X-X-G motif; other site
298654002839	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
298654002840	G-X-X-G motif; other site
298654002841	Protein of unknown function (DUF448); Region: DUF448; pfam04296
298654002842	putative RNA binding cleft [nucleotide binding]; other site
298654002843	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
298654002844	translation initiation factor IF-2; Region: IF-2; TIGR00487
298654002845	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
298654002846	G1 box; other site
298654002847	putative GEF interaction site [polypeptide binding]; other site
298654002848	GTP/Mg2+ binding site [chemical binding]; other site
298654002849	Switch I region; other site
298654002850	G2 box; other site
298654002851	G3 box; other site
298654002852	Switch II region; other site
298654002853	G4 box; other site
298654002854	G5 box; other site
298654002855	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
298654002856	Translation-initiation factor 2; Region: IF-2; pfam11987
298654002857	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
298654002858	Protein of unknown function (DUF503); Region: DUF503; pfam04456
298654002859	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
298654002860	DHH family; Region: DHH; pfam01368
298654002861	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
298654002862	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
298654002863	RNA binding site [nucleotide binding]; other site
298654002864	active site
298654002865	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
298654002866	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
298654002867	active site
298654002868	Riboflavin kinase; Region: Flavokinase; pfam01687
298654002869	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
298654002870	16S/18S rRNA binding site [nucleotide binding]; other site
298654002871	S13e-L30e interaction site [polypeptide binding]; other site
298654002872	25S rRNA binding site [nucleotide binding]; other site
298654002873	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
298654002874	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
298654002875	RNase E interface [polypeptide binding]; other site
298654002876	trimer interface [polypeptide binding]; other site
298654002877	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
298654002878	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
298654002879	RNase E interface [polypeptide binding]; other site
298654002880	trimer interface [polypeptide binding]; other site
298654002881	active site
298654002882	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
298654002883	putative nucleic acid binding region [nucleotide binding]; other site
298654002884	G-X-X-G motif; other site
298654002885	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
298654002886	RNA binding site [nucleotide binding]; other site
298654002887	domain interface; other site
298654002888	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298654002889	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298654002890	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298654002891	dihydrodipicolinate reductase; Provisional; Region: PRK00048
298654002892	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654002893	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
298654002894	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
298654002895	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654002896	nucleotide binding site [chemical binding]; other site
298654002897	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654002898	SBD interface [polypeptide binding]; other site
298654002899	histidyl-tRNA synthetase; Region: hisS; TIGR00442
298654002900	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
298654002901	dimer interface [polypeptide binding]; other site
298654002902	motif 1; other site
298654002903	active site
298654002904	motif 2; other site
298654002905	motif 3; other site
298654002906	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
298654002907	anticodon binding site; other site
298654002908	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
298654002909	RNA polymerase sigma factor; Provisional; Region: PRK12528
298654002910	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654002911	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654002912	DNA binding residues [nucleotide binding]
298654002913	putative phosphoketolase; Provisional; Region: PRK05261
298654002914	XFP N-terminal domain; Region: XFP_N; pfam09364
298654002915	XFP C-terminal domain; Region: XFP_C; pfam09363
298654002916	Acetokinase family; Region: Acetate_kinase; cl17229
298654002917	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
298654002918	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
298654002919	dimer interface [polypeptide binding]; other site
298654002920	active site
298654002921	catalytic residue [active]
298654002922	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
298654002923	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654002924	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
298654002925	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654002926	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654002927	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
298654002928	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
298654002929	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654002930	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
298654002931	Helix-turn-helix domain; Region: HTH_25; pfam13413
298654002932	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
298654002933	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
298654002934	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
298654002935	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654002936	FeS/SAM binding site; other site
298654002937	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
298654002938	competence damage-inducible protein A; Provisional; Region: PRK00549
298654002939	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
298654002940	putative MPT binding site; other site
298654002941	Competence-damaged protein; Region: CinA; pfam02464
298654002942	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654002943	sequence-specific DNA binding site [nucleotide binding]; other site
298654002944	salt bridge; other site
298654002945	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
298654002946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654002947	putative substrate translocation pore; other site
298654002948	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654002949	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
298654002950	ATP binding site [chemical binding]; other site
298654002951	putative Mg++ binding site [ion binding]; other site
298654002952	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654002953	nucleotide binding region [chemical binding]; other site
298654002954	ATP-binding site [chemical binding]; other site
298654002955	DEAD/H associated; Region: DEAD_assoc; pfam08494
298654002956	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
298654002957	recombinase A; Provisional; Region: recA; PRK09354
298654002958	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
298654002959	hexamer interface [polypeptide binding]; other site
298654002960	Walker A motif; other site
298654002961	ATP binding site [chemical binding]; other site
298654002962	Walker B motif; other site
298654002963	recombination regulator RecX; Reviewed; Region: recX; PRK00117
298654002964	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
298654002965	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
298654002966	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298654002967	Zn2+ binding site [ion binding]; other site
298654002968	Mg2+ binding site [ion binding]; other site
298654002969	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
298654002970	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
298654002971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654002972	FeS/SAM binding site; other site
298654002973	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
298654002974	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654002975	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
298654002976	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
298654002977	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654002978	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
298654002979	active site
298654002980	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
298654002981	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
298654002982	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
298654002983	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
298654002984	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
298654002985	HflX GTPase family; Region: HflX; cd01878
298654002986	G1 box; other site
298654002987	GTP/Mg2+ binding site [chemical binding]; other site
298654002988	Switch I region; other site
298654002989	G2 box; other site
298654002990	G3 box; other site
298654002991	Switch II region; other site
298654002992	G4 box; other site
298654002993	G5 box; other site
298654002994	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
298654002995	AAA domain; Region: AAA_14; pfam13173
298654002996	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
298654002997	LexA repressor; Validated; Region: PRK00215
298654002998	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
298654002999	Catalytic site [active]
298654003000	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
298654003001	ATP cone domain; Region: ATP-cone; pfam03477
298654003002	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
298654003003	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
298654003004	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
298654003005	active site
298654003006	dimer interface [polypeptide binding]; other site
298654003007	effector binding site; other site
298654003008	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
298654003009	TSCPD domain; Region: TSCPD; pfam12637
298654003010	RDD family; Region: RDD; pfam06271
298654003011	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
298654003012	Predicted membrane protein [Function unknown]; Region: COG2246
298654003013	GtrA-like protein; Region: GtrA; pfam04138
298654003014	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654003015	hydrophobic ligand binding site; other site
298654003016	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
298654003017	putative DNA binding site [nucleotide binding]; other site
298654003018	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
298654003019	putative hydrophobic ligand binding site [chemical binding]; other site
298654003020	Trehalase; Region: Trehalase; cl17346
298654003021	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
298654003022	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298654003023	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654003024	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298654003025	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654003026	DNA binding residues [nucleotide binding]
298654003027	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
298654003028	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654003029	acyl-activating enzyme (AAE) consensus motif; other site
298654003030	AMP binding site [chemical binding]; other site
298654003031	active site
298654003032	CoA binding site [chemical binding]; other site
298654003033	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
298654003034	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
298654003035	active site
298654003036	Zn binding site [ion binding]; other site
298654003037	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654003038	CoA binding domain; Region: CoA_binding_2; pfam13380
298654003039	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
298654003040	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
298654003041	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
298654003042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654003043	putative active site [active]
298654003044	heme pocket [chemical binding]; other site
298654003045	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654003046	GAF domain; Region: GAF_3; pfam13492
298654003047	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654003048	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
298654003049	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
298654003050	Walker A/P-loop; other site
298654003051	ATP binding site [chemical binding]; other site
298654003052	Q-loop/lid; other site
298654003053	ABC transporter signature motif; other site
298654003054	Walker B; other site
298654003055	D-loop; other site
298654003056	H-loop/switch region; other site
298654003057	Lsr2; Region: Lsr2; pfam11774
298654003058	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
298654003059	proline aminopeptidase P II; Provisional; Region: PRK10879
298654003060	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
298654003061	active site
298654003062	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
298654003063	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
298654003064	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
298654003065	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654003066	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654003067	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
298654003068	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654003069	FeS/SAM binding site; other site
298654003070	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
298654003071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654003072	Walker A motif; other site
298654003073	ATP binding site [chemical binding]; other site
298654003074	Walker B motif; other site
298654003075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298654003076	Peptidase family M41; Region: Peptidase_M41; pfam01434
298654003077	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654003078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654003079	putative substrate translocation pore; other site
298654003080	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654003081	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
298654003082	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298654003083	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654003084	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298654003085	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654003086	dimer interface [polypeptide binding]; other site
298654003087	active site
298654003088	acyl carrier protein; Provisional; Region: acpP; PRK00982
298654003089	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
298654003090	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
298654003091	dimer interface [polypeptide binding]; other site
298654003092	active site
298654003093	CoA binding pocket [chemical binding]; other site
298654003094	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298654003095	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654003096	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
298654003097	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654003098	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654003099	catalytic residue [active]
298654003100	Protein of unknown function (DUF664); Region: DUF664; pfam04978
298654003101	DinB superfamily; Region: DinB_2; pfam12867
298654003102	Protein of unknown function (DUF664); Region: DUF664; pfam04978
298654003103	DinB superfamily; Region: DinB_2; pfam12867
298654003104	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654003105	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
298654003106	catalytic triad [active]
298654003107	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
298654003108	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
298654003109	Thioredoxin; Region: Thioredoxin_4; pfam13462
298654003110	Methylamine utilisation protein MauE; Region: MauE; pfam07291
298654003111	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
298654003112	Cu(I) binding site [ion binding]; other site
298654003113	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
298654003114	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654003115	catalytic core [active]
298654003116	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
298654003117	catalytic residues [active]
298654003118	dimer interface [polypeptide binding]; other site
298654003119	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654003120	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654003121	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
298654003122	oligomerisation interface [polypeptide binding]; other site
298654003123	mobile loop; other site
298654003124	roof hairpin; other site
298654003125	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003126	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003127	active site
298654003128	phosphorylation site [posttranslational modification]
298654003129	intermolecular recognition site; other site
298654003130	dimerization interface [polypeptide binding]; other site
298654003131	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003132	DNA binding residues [nucleotide binding]
298654003133	dimerization interface [polypeptide binding]; other site
298654003134	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654003135	yiaA/B two helix domain; Region: YiaAB; cl01759
298654003136	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
298654003137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003139	DNA binding residues [nucleotide binding]
298654003140	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003141	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003142	DNA binding residues [nucleotide binding]
298654003143	dimerization interface [polypeptide binding]; other site
298654003144	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654003145	phosphate binding site [ion binding]; other site
298654003146	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654003147	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654003148	active site
298654003149	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298654003150	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654003151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654003152	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654003153	NAD(P) binding site [chemical binding]; other site
298654003154	active site
298654003155	Beta-ketoacyl synthase, N-terminal domain; Region: ketoacyl-synt; pfam00109
298654003156	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
298654003157	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654003158	active site
298654003159	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298654003160	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
298654003161	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654003162	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654003163	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654003164	catalytic site [active]
298654003165	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
298654003166	glycosyltransferase, MGT family; Region: MGT; TIGR01426
298654003167	active site
298654003168	TDP-binding site; other site
298654003169	acceptor substrate-binding pocket; other site
298654003170	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654003171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654003172	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654003173	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654003174	putative ligand binding site [chemical binding]; other site
298654003175	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654003176	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
298654003177	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
298654003178	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
298654003179	DAK2 domain; Region: Dak2; cl03685
298654003180	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654003181	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654003182	active site
298654003183	ATP binding site [chemical binding]; other site
298654003184	substrate binding site [chemical binding]; other site
298654003185	activation loop (A-loop); other site
298654003186	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654003187	classical (c) SDRs; Region: SDR_c; cd05233
298654003188	NAD(P) binding site [chemical binding]; other site
298654003189	active site
298654003190	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003191	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003192	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654003193	nudix motif; other site
298654003194	mercuric reductase; Validated; Region: PRK06370
298654003195	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654003196	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298654003197	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
298654003198	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654003199	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003200	active site
298654003201	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
298654003202	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003203	active site
298654003204	TM2 domain; Region: TM2; pfam05154
298654003205	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298654003206	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
298654003207	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654003208	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654003209	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
298654003210	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
298654003211	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
298654003212	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654003213	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654003214	kynureninase; Region: kynureninase; TIGR01814
298654003215	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654003216	3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264
298654003217	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298654003218	homotrimer interaction site [polypeptide binding]; other site
298654003219	putative active site [active]
298654003220	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
298654003221	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
298654003222	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
298654003223	NAD binding site [chemical binding]; other site
298654003224	catalytic residues [active]
298654003225	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
298654003226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
298654003227	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654003228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654003229	ABC-ATPase subunit interface; other site
298654003230	putative PBP binding loops; other site
298654003231	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654003232	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654003233	Walker A/P-loop; other site
298654003234	ATP binding site [chemical binding]; other site
298654003235	Q-loop/lid; other site
298654003236	ABC transporter signature motif; other site
298654003237	Walker B; other site
298654003238	D-loop; other site
298654003239	H-loop/switch region; other site
298654003240	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
298654003241	PAS domain; Region: PAS; smart00091
298654003242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654003243	ATP binding site [chemical binding]; other site
298654003244	Mg2+ binding site [ion binding]; other site
298654003245	G-X-G motif; other site
298654003246	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
298654003247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003248	active site
298654003249	phosphorylation site [posttranslational modification]
298654003250	intermolecular recognition site; other site
298654003251	dimerization interface [polypeptide binding]; other site
298654003252	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
298654003253	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654003254	dimer interface [polypeptide binding]; other site
298654003255	active site
298654003256	short chain dehydrogenase; Provisional; Region: PRK07856
298654003257	classical (c) SDRs; Region: SDR_c; cd05233
298654003258	NAD(P) binding site [chemical binding]; other site
298654003259	active site
298654003260	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
298654003261	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654003262	active site
298654003263	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
298654003264	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654003265	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654003266	active site
298654003267	metal binding site [ion binding]; metal-binding site
298654003268	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298654003269	cytoskeletal protein RodZ; Provisional; Region: PRK10856
298654003270	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654003271	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654003272	substrate binding site [chemical binding]; other site
298654003273	oxyanion hole (OAH) forming residues; other site
298654003274	trimer interface [polypeptide binding]; other site
298654003275	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003276	active site
298654003277	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003278	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654003279	active site
298654003280	enoyl-CoA hydratase; Provisional; Region: PRK06495
298654003281	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654003282	substrate binding site [chemical binding]; other site
298654003283	oxyanion hole (OAH) forming residues; other site
298654003284	trimer interface [polypeptide binding]; other site
298654003285	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654003286	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654003287	Carboxylesterase family; Region: COesterase; pfam00135
298654003288	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654003289	substrate binding pocket [chemical binding]; other site
298654003290	catalytic triad [active]
298654003291	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654003292	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654003293	[2Fe-2S] cluster binding site [ion binding]; other site
298654003294	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
298654003295	putative alpha subunit interface [polypeptide binding]; other site
298654003296	putative active site [active]
298654003297	putative substrate binding site [chemical binding]; other site
298654003298	Fe binding site [ion binding]; other site
298654003299	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
298654003300	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
298654003301	hydroxyglutarate oxidase; Provisional; Region: PRK11728
298654003302	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
298654003303	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
298654003304	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298654003305	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298654003306	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
298654003307	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654003308	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654003309	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654003310	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
298654003311	Phosphotransferase enzyme family; Region: APH; pfam01636
298654003312	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654003313	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654003314	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654003315	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654003316	Flavoprotein; Region: Flavoprotein; pfam02441
298654003317	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654003318	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654003319	non-specific DNA binding site [nucleotide binding]; other site
298654003320	salt bridge; other site
298654003321	sequence-specific DNA binding site [nucleotide binding]; other site
298654003322	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298654003323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298654003324	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298654003325	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003326	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003327	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003328	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003329	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003330	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003331	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003332	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003333	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003334	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
298654003335	classical (c) SDRs; Region: SDR_c; cd05233
298654003336	NAD(P) binding site [chemical binding]; other site
298654003337	active site
298654003338	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654003339	classical (c) SDRs; Region: SDR_c; cd05233
298654003340	NAD(P) binding site [chemical binding]; other site
298654003341	active site
298654003342	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654003343	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654003344	putative ligand binding site [chemical binding]; other site
298654003345	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298654003346	Putative esterase; Region: Esterase; pfam00756
298654003347	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
298654003348	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
298654003349	active site clefts [active]
298654003350	zinc binding site [ion binding]; other site
298654003351	dimer interface [polypeptide binding]; other site
298654003352	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654003353	MarR family; Region: MarR; pfam01047
298654003354	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
298654003355	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654003356	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654003357	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003358	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654003359	active site
298654003360	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654003361	Cupin domain; Region: Cupin_2; cl17218
298654003362	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
298654003363	short chain dehydrogenase; Provisional; Region: PRK06123
298654003364	NADP binding site [chemical binding]; other site
298654003365	substrate binding site [chemical binding]; other site
298654003366	active site
298654003367	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654003368	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
298654003369	NAD(P) binding site [chemical binding]; other site
298654003370	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654003371	dimerization interface [polypeptide binding]; other site
298654003372	putative DNA binding site [nucleotide binding]; other site
298654003373	putative Zn2+ binding site [ion binding]; other site
298654003374	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654003375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654003376	putative substrate translocation pore; other site
298654003377	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654003378	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654003379	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298654003380	dimer interface [polypeptide binding]; other site
298654003381	active site
298654003382	Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832
298654003383	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654003384	active site
298654003385	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654003386	N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus  OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861
298654003387	putative hydrophobic ligand binding site [chemical binding]; other site
298654003388	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654003389	hydrophobic ligand binding site; other site
298654003390	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654003391	O-methyltransferase; Region: Methyltransf_2; pfam00891
298654003392	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
298654003393	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654003394	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654003395	Histidine kinase; Region: HisKA_3; pfam07730
298654003396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654003397	ATP binding site [chemical binding]; other site
298654003398	Mg2+ binding site [ion binding]; other site
298654003399	G-X-G motif; other site
298654003400	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003402	active site
298654003403	phosphorylation site [posttranslational modification]
298654003404	intermolecular recognition site; other site
298654003405	dimerization interface [polypeptide binding]; other site
298654003406	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003407	DNA binding residues [nucleotide binding]
298654003408	dimerization interface [polypeptide binding]; other site
298654003409	Polyketide ketoreductase, classical (c) SDR; Region: PKR_SDR_c; cd08945
298654003410	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654003411	NAD(P) binding site [chemical binding]; other site
298654003412	homodimer interface [polypeptide binding]; other site
298654003413	substrate binding site [chemical binding]; other site
298654003414	active site
298654003415	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
298654003416	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
298654003417	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654003418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654003419	dimer interface [polypeptide binding]; other site
298654003420	conserved gate region; other site
298654003421	putative PBP binding loops; other site
298654003422	ABC-ATPase subunit interface; other site
298654003423	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
298654003424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654003425	dimer interface [polypeptide binding]; other site
298654003426	conserved gate region; other site
298654003427	putative PBP binding loops; other site
298654003428	ABC-ATPase subunit interface; other site
298654003429	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
298654003430	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654003431	Walker A/P-loop; other site
298654003432	ATP binding site [chemical binding]; other site
298654003433	Q-loop/lid; other site
298654003434	ABC transporter signature motif; other site
298654003435	Walker B; other site
298654003436	D-loop; other site
298654003437	H-loop/switch region; other site
298654003438	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654003439	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654003440	Walker A/P-loop; other site
298654003441	ATP binding site [chemical binding]; other site
298654003442	Q-loop/lid; other site
298654003443	ABC transporter signature motif; other site
298654003444	Walker B; other site
298654003445	D-loop; other site
298654003446	H-loop/switch region; other site
298654003447	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
298654003448	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654003449	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654003450	substrate binding pocket [chemical binding]; other site
298654003451	active site
298654003452	iron coordination sites [ion binding]; other site
298654003453	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270
298654003454	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654003455	putative NAD(P) binding site [chemical binding]; other site
298654003456	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
298654003457	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298654003458	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654003459	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654003460	catalytic core [active]
298654003461	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654003462	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654003463	Predicted acetyltransferase [General function prediction only]; Region: COG2388
298654003464	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
298654003465	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654003466	NAD(P) binding site [chemical binding]; other site
298654003467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003469	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
298654003470	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
298654003471	FAD binding pocket [chemical binding]; other site
298654003472	FAD binding motif [chemical binding]; other site
298654003473	phosphate binding motif [ion binding]; other site
298654003474	NAD binding pocket [chemical binding]; other site
298654003475	TrkA-N domain; Region: TrkA_N; pfam02254
298654003476	Ion channel; Region: Ion_trans_2; pfam07885
298654003477	TrkA-N domain; Region: TrkA_N; pfam02254
298654003478	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654003479	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654003480	phosphopeptide binding site; other site
298654003481	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
298654003482	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654003483	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654003484	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
298654003485	AAA domain; Region: AAA_22; pfam13401
298654003486	RHS Repeat; Region: RHS_repeat; cl11982
298654003487	RHS Repeat; Region: RHS_repeat; pfam05593
298654003488	RHS Repeat; Region: RHS_repeat; pfam05593
298654003489	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
298654003490	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
298654003491	RHS Repeat; Region: RHS_repeat; pfam05593
298654003492	RHS Repeat; Region: RHS_repeat; pfam05593
298654003493	RHS Repeat; Region: RHS_repeat; pfam05593
298654003494	RHS protein; Region: RHS; pfam03527
298654003495	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
298654003496	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
298654003497	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654003498	hydrophobic ligand binding site; other site
298654003499	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654003500	putative DNA binding site [nucleotide binding]; other site
298654003501	putative Zn2+ binding site [ion binding]; other site
298654003502	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
298654003503	DNA binding site [nucleotide binding]
298654003504	active site
298654003505	catalytic site [active]
298654003506	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
298654003507	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
298654003508	heme-binding site [chemical binding]; other site
298654003509	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654003510	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
298654003511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654003512	Walker A/P-loop; other site
298654003513	ATP binding site [chemical binding]; other site
298654003514	Q-loop/lid; other site
298654003515	ABC transporter signature motif; other site
298654003516	Walker B; other site
298654003517	D-loop; other site
298654003518	H-loop/switch region; other site
298654003519	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
298654003520	putative active site [active]
298654003521	catalytic site [active]
298654003522	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003523	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003524	DNA binding residues [nucleotide binding]
298654003525	dimerization interface [polypeptide binding]; other site
298654003526	Nitrate and nitrite sensing; Region: NIT; pfam08376
298654003527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654003528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654003529	ATP binding site [chemical binding]; other site
298654003530	Mg2+ binding site [ion binding]; other site
298654003531	G-X-G motif; other site
298654003532	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
298654003533	Protein of unknown function (DUF742); Region: DUF742; pfam05331
298654003534	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
298654003535	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298654003536	G2 box; other site
298654003537	Switch I region; other site
298654003538	G3 box; other site
298654003539	Switch II region; other site
298654003540	GTP/Mg2+ binding site [chemical binding]; other site
298654003541	G4 box; other site
298654003542	G5 box; other site
298654003543	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
298654003544	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654003545	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654003546	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654003547	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
298654003548	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654003549	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003550	active site
298654003551	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654003552	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654003553	active site
298654003554	enoyl-CoA hydratase; Provisional; Region: PRK07799
298654003555	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654003556	substrate binding site [chemical binding]; other site
298654003557	oxyanion hole (OAH) forming residues; other site
298654003558	trimer interface [polypeptide binding]; other site
298654003559	acyl-CoA synthetase; Validated; Region: PRK07798
298654003560	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654003561	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
298654003562	acyl-activating enzyme (AAE) consensus motif; other site
298654003563	acyl-activating enzyme (AAE) consensus motif; other site
298654003564	putative AMP binding site [chemical binding]; other site
298654003565	putative active site [active]
298654003566	putative CoA binding site [chemical binding]; other site
298654003567	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
298654003568	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
298654003569	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003571	active site
298654003572	phosphorylation site [posttranslational modification]
298654003573	intermolecular recognition site; other site
298654003574	dimerization interface [polypeptide binding]; other site
298654003575	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003576	DNA binding residues [nucleotide binding]
298654003577	dimerization interface [polypeptide binding]; other site
298654003578	GAF domain; Region: GAF_3; pfam13492
298654003579	GAF domain; Region: GAF_2; pfam13185
298654003580	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654003581	Histidine kinase; Region: HisKA_3; pfam07730
298654003582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654003583	ATP binding site [chemical binding]; other site
298654003584	Mg2+ binding site [ion binding]; other site
298654003585	G-X-G motif; other site
298654003586	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
298654003587	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
298654003588	putative active site [active]
298654003589	putative substrate binding site [chemical binding]; other site
298654003590	putative FMN binding site [chemical binding]; other site
298654003591	putative catalytic residues [active]
298654003592	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
298654003593	conserved cys residue [active]
298654003594	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654003595	FOG: PKD repeat [General function prediction only]; Region: COG3291
298654003596	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
298654003597	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
298654003598	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
298654003599	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654003600	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654003601	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
298654003602	hypothetical protein; Provisional; Region: PRK08204
298654003603	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654003604	active site
298654003605	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
298654003606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654003607	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298654003608	dimerization interface [polypeptide binding]; other site
298654003609	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654003610	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654003611	metal binding site [ion binding]; metal-binding site
298654003612	active site
298654003613	I-site; other site
298654003614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654003615	PAS domain; Region: PAS_9; pfam13426
298654003616	putative active site [active]
298654003617	heme pocket [chemical binding]; other site
298654003618	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654003619	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654003620	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
298654003621	putative FMN binding site [chemical binding]; other site
298654003622	Part of AAA domain; Region: AAA_19; pfam13245
298654003623	Family description; Region: UvrD_C_2; pfam13538
298654003624	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298654003625	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
298654003626	active site
298654003627	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654003628	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654003629	[2Fe-2S] cluster binding site [ion binding]; other site
298654003630	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654003631	alpha subunit interface [polypeptide binding]; other site
298654003632	active site
298654003633	substrate binding site [chemical binding]; other site
298654003634	Fe binding site [ion binding]; other site
298654003635	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654003636	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654003637	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654003638	NAD(P) binding site [chemical binding]; other site
298654003639	active site
298654003640	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003641	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003642	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654003643	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654003644	substrate binding pocket [chemical binding]; other site
298654003645	active site
298654003646	iron coordination sites [ion binding]; other site
298654003647	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654003648	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654003649	[2Fe-2S] cluster binding site [ion binding]; other site
298654003650	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654003651	alpha subunit interface [polypeptide binding]; other site
298654003652	active site
298654003653	substrate binding site [chemical binding]; other site
298654003654	Fe binding site [ion binding]; other site
298654003655	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654003656	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654003657	NAD binding site [chemical binding]; other site
298654003658	catalytic residues [active]
298654003659	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654003660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654003661	S-adenosylmethionine binding site [chemical binding]; other site
298654003662	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
298654003663	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
298654003664	FOG: PKD repeat [General function prediction only]; Region: COG3291
298654003665	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
298654003666	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
298654003667	PAS domain; Region: PAS_9; pfam13426
298654003668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654003669	putative active site [active]
298654003670	heme pocket [chemical binding]; other site
298654003671	PAS fold; Region: PAS_4; pfam08448
298654003672	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654003673	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654003674	metal binding site [ion binding]; metal-binding site
298654003675	active site
298654003676	I-site; other site
298654003677	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654003678	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654003679	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654003680	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003681	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003682	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654003683	active site
298654003684	catalytic triad [active]
298654003685	oxyanion hole [active]
298654003686	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654003687	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654003688	NAD(P) binding site [chemical binding]; other site
298654003689	catalytic residues [active]
298654003690	Putative sensor; Region: Sensor; pfam13796
298654003691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654003692	Histidine kinase; Region: HisKA_3; pfam07730
298654003693	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003695	active site
298654003696	phosphorylation site [posttranslational modification]
298654003697	intermolecular recognition site; other site
298654003698	dimerization interface [polypeptide binding]; other site
298654003699	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003700	DNA binding residues [nucleotide binding]
298654003701	dimerization interface [polypeptide binding]; other site
298654003702	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654003703	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
298654003704	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654003705	Cytochrome P450; Region: p450; cl12078
298654003706	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003707	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003708	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654003709	dimerization interface [polypeptide binding]; other site
298654003710	putative DNA binding site [nucleotide binding]; other site
298654003711	putative Zn2+ binding site [ion binding]; other site
298654003712	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
298654003713	putative hydrophobic ligand binding site [chemical binding]; other site
298654003714	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
298654003715	RibD C-terminal domain; Region: RibD_C; cl17279
298654003716	TspO/MBR family; Region: TspO_MBR; pfam03073
298654003717	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654003718	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654003719	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654003720	DNA-binding site [nucleotide binding]; DNA binding site
298654003721	FCD domain; Region: FCD; pfam07729
298654003722	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654003723	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654003724	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654003725	non-specific DNA binding site [nucleotide binding]; other site
298654003726	salt bridge; other site
298654003727	sequence-specific DNA binding site [nucleotide binding]; other site
298654003728	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654003729	TIR domain; Region: TIR_2; pfam13676
298654003730	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654003731	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654003732	structural tetrad; other site
298654003733	NB-ARC domain; Region: NB-ARC; pfam00931
298654003734	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003735	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003736	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003737	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003738	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003739	Tetratricopeptide repeat; Region: TPR_10; cl17452
298654003740	AAA ATPase domain; Region: AAA_16; pfam13191
298654003741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654003742	binding surface
298654003743	TPR motif; other site
298654003744	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003745	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003746	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003747	Protein of unknown function, DUF399; Region: DUF399; cl01139
298654003748	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298654003749	FtsX-like permease family; Region: FtsX; pfam02687
298654003750	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
298654003751	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654003752	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654003753	Walker A/P-loop; other site
298654003754	ATP binding site [chemical binding]; other site
298654003755	Q-loop/lid; other site
298654003756	ABC transporter signature motif; other site
298654003757	Walker B; other site
298654003758	D-loop; other site
298654003759	H-loop/switch region; other site
298654003760	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654003761	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654003762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003763	active site
298654003764	phosphorylation site [posttranslational modification]
298654003765	intermolecular recognition site; other site
298654003766	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654003767	DNA binding site [nucleotide binding]
298654003768	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654003769	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654003770	dimerization interface [polypeptide binding]; other site
298654003771	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654003772	dimer interface [polypeptide binding]; other site
298654003773	phosphorylation site [posttranslational modification]
298654003774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654003775	ATP binding site [chemical binding]; other site
298654003776	Mg2+ binding site [ion binding]; other site
298654003777	G-X-G motif; other site
298654003778	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
298654003779	apolar tunnel; other site
298654003780	heme binding site [chemical binding]; other site
298654003781	dimerization interface [polypeptide binding]; other site
298654003782	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654003783	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
298654003784	DNA binding residues [nucleotide binding]
298654003785	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
298654003786	AAA domain; Region: AAA_14; pfam13173
298654003787	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298654003788	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654003789	short chain dehydrogenase; Provisional; Region: PRK07774
298654003790	classical (c) SDRs; Region: SDR_c; cd05233
298654003791	NAD(P) binding site [chemical binding]; other site
298654003792	active site
298654003793	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654003794	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654003795	NAD(P) binding site [chemical binding]; other site
298654003796	catalytic residues [active]
298654003797	classical (c) SDRs; Region: SDR_c; cd05233
298654003798	NAD(P) binding site [chemical binding]; other site
298654003799	active site
298654003800	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
298654003801	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654003802	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
298654003803	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003804	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003805	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654003806	Cytochrome P450; Region: p450; cl12078
298654003807	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003808	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003809	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654003810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654003811	NAD(P) binding site [chemical binding]; other site
298654003812	active site
298654003813	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654003814	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654003815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654003816	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654003817	NAD(P) binding site [chemical binding]; other site
298654003818	active site
298654003819	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654003820	Cytochrome P450; Region: p450; cl12078
298654003821	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003822	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003823	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654003824	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654003825	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654003826	active site
298654003827	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654003828	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
298654003829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003830	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
298654003831	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
298654003832	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
298654003833	putative catalytic cysteine [active]
298654003834	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654003835	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003836	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003837	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654003839	binding surface
298654003840	TPR motif; other site
298654003841	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003842	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003843	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003844	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003845	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003846	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003847	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003848	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003849	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003850	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
298654003851	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654003852	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654003853	FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363
298654003854	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
298654003855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654003856	S-adenosylmethionine binding site [chemical binding]; other site
298654003857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654003858	sequence-specific DNA binding site [nucleotide binding]; other site
298654003859	salt bridge; other site
298654003860	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
298654003861	aromatic arch; other site
298654003862	DCoH dimer interaction site [polypeptide binding]; other site
298654003863	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
298654003864	DCoH tetramer interaction site [polypeptide binding]; other site
298654003865	substrate binding site [chemical binding]; other site
298654003866	TIR domain; Region: TIR_2; pfam13676
298654003867	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654003868	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654003869	structural tetrad; other site
298654003870	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654003871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654003872	non-specific DNA binding site [nucleotide binding]; other site
298654003873	salt bridge; other site
298654003874	sequence-specific DNA binding site [nucleotide binding]; other site
298654003875	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
298654003876	Phosphotransferase enzyme family; Region: APH; pfam01636
298654003877	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298654003878	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298654003879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298654003880	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298654003881	integron integrase; Region: integrase_gron; TIGR02249
298654003882	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654003883	active site
298654003884	Int/Topo IB signature motif; other site
298654003885	DNA binding site [nucleotide binding]
298654003886	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654003887	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298654003888	S-adenosylmethionine binding site [chemical binding]; other site
298654003889	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654003890	Cytochrome P450; Region: p450; cl12078
298654003891	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654003892	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654003893	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654003894	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
298654003895	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654003896	acyl-activating enzyme (AAE) consensus motif; other site
298654003897	acyl-activating enzyme (AAE) consensus motif; other site
298654003898	putative AMP binding site [chemical binding]; other site
298654003899	putative active site [active]
298654003900	putative CoA binding site [chemical binding]; other site
298654003901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654003902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654003903	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654003904	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654003905	DNA-binding site [nucleotide binding]; DNA binding site
298654003906	FCD domain; Region: FCD; pfam07729
298654003907	Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
298654003908	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
298654003909	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654003910	FAD binding domain; Region: FAD_binding_4; pfam01565
298654003911	Berberine and berberine like; Region: BBE; pfam08031
298654003912	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298654003913	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
298654003914	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
298654003915	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654003916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654003917	dimer interface [polypeptide binding]; other site
298654003918	conserved gate region; other site
298654003919	putative PBP binding loops; other site
298654003920	ABC-ATPase subunit interface; other site
298654003921	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
298654003922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654003923	dimer interface [polypeptide binding]; other site
298654003924	conserved gate region; other site
298654003925	putative PBP binding loops; other site
298654003926	ABC-ATPase subunit interface; other site
298654003927	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654003928	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
298654003929	Walker A/P-loop; other site
298654003930	ATP binding site [chemical binding]; other site
298654003931	Q-loop/lid; other site
298654003932	ABC transporter signature motif; other site
298654003933	Walker B; other site
298654003934	D-loop; other site
298654003935	H-loop/switch region; other site
298654003936	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654003937	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
298654003938	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654003939	Walker A/P-loop; other site
298654003940	ATP binding site [chemical binding]; other site
298654003941	Q-loop/lid; other site
298654003942	ABC transporter signature motif; other site
298654003943	Walker B; other site
298654003944	D-loop; other site
298654003945	H-loop/switch region; other site
298654003946	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654003947	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
298654003948	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
298654003949	nucleoside/Zn binding site; other site
298654003950	dimer interface [polypeptide binding]; other site
298654003951	catalytic motif [active]
298654003952	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298654003953	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654003954	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654003955	active site
298654003956	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
298654003957	putative active site [active]
298654003958	PRP8 domain IV core; Region: PRP8_domainIV; pfam12134
298654003959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654003960	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654003961	dimerization interface [polypeptide binding]; other site
298654003962	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654003963	dimer interface [polypeptide binding]; other site
298654003964	phosphorylation site [posttranslational modification]
298654003965	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654003966	ATP binding site [chemical binding]; other site
298654003967	Mg2+ binding site [ion binding]; other site
298654003968	G-X-G motif; other site
298654003969	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654003970	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654003971	active site
298654003972	phosphorylation site [posttranslational modification]
298654003973	intermolecular recognition site; other site
298654003974	dimerization interface [polypeptide binding]; other site
298654003975	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654003976	DNA binding site [nucleotide binding]
298654003977	AAA ATPase domain; Region: AAA_16; pfam13191
298654003978	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654003979	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654003980	DNA binding residues [nucleotide binding]
298654003981	glutathione synthetase; Provisional; Region: PRK05246
298654003982	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
298654003983	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
298654003984	MAPEG family; Region: MAPEG; pfam01124
298654003985	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654003986	Fic family protein [Function unknown]; Region: COG3177
298654003987	Fic/DOC family; Region: Fic; pfam02661
298654003988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654003989	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
298654003990	NAD(P) binding site [chemical binding]; other site
298654003991	active site
298654003992	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298654003993	acyl-CoA thioesterase II; Region: tesB; TIGR00189
298654003994	active site
298654003995	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654003996	catalytic triad [active]
298654003997	dimer interface [polypeptide binding]; other site
298654003998	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654003999	active site
298654004000	metal binding site [ion binding]; metal-binding site
298654004001	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654004002	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654004003	DNA-binding site [nucleotide binding]; DNA binding site
298654004004	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654004005	classical (c) SDRs; Region: SDR_c; cd05233
298654004006	NAD(P) binding site [chemical binding]; other site
298654004007	active site
298654004008	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654004009	active site 2 [active]
298654004010	active site 1 [active]
298654004011	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654004012	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654004013	putative ligand binding site [chemical binding]; other site
298654004014	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
298654004015	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654004016	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654004017	putative ligand binding site [chemical binding]; other site
298654004018	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
298654004019	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654004020	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654004021	DNA binding residues [nucleotide binding]
298654004022	TIR domain; Region: TIR_2; pfam13676
298654004023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654004024	putative substrate translocation pore; other site
298654004025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654004026	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004027	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
298654004028	active site
298654004029	putative substrate binding region [chemical binding]; other site
298654004030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654004031	NAD(P) binding site [chemical binding]; other site
298654004032	active site
298654004033	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654004034	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654004035	YCII-related domain; Region: YCII; cl00999
298654004036	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654004037	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654004038	Walker A/P-loop; other site
298654004039	ATP binding site [chemical binding]; other site
298654004040	Q-loop/lid; other site
298654004041	ABC transporter signature motif; other site
298654004042	Walker B; other site
298654004043	D-loop; other site
298654004044	H-loop/switch region; other site
298654004045	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
298654004046	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
298654004047	active site
298654004048	TDP-binding site; other site
298654004049	acceptor substrate-binding pocket; other site
298654004050	homodimer interface [polypeptide binding]; other site
298654004051	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654004052	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654004053	Phosphopantetheine attachment site; Region: PP-binding; cl09936
298654004054	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654004055	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
298654004056	active site
298654004057	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298654004058	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
298654004059	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654004060	phosphate binding site [ion binding]; other site
298654004061	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654004062	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
298654004063	active site
298654004064	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298654004065	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654004066	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
298654004067	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654004068	putative NADP binding site [chemical binding]; other site
298654004069	active site
298654004070	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298654004071	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298654004072	Ion transport protein; Region: Ion_trans; pfam00520
298654004073	Ion channel; Region: Ion_trans_2; pfam07885
298654004074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654004075	S-adenosylmethionine binding site [chemical binding]; other site
298654004076	4Fe-4S binding domain; Region: Fer4; pfam00037
298654004077	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
298654004078	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654004079	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654004080	dimerization interface [polypeptide binding]; other site
298654004081	putative DNA binding site [nucleotide binding]; other site
298654004082	putative Zn2+ binding site [ion binding]; other site
298654004083	Hemerythrin-like domain; Region: Hr-like; cd12108
298654004084	Fe binding site [ion binding]; other site
298654004085	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298654004086	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298654004087	ligand binding site [chemical binding]; other site
298654004088	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
298654004089	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
298654004090	putative DNA binding site [nucleotide binding]; other site
298654004091	catalytic residue [active]
298654004092	putative H2TH interface [polypeptide binding]; other site
298654004093	putative catalytic residues [active]
298654004094	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
298654004095	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654004096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654004097	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654004098	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004099	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654004100	hypothetical protein; Provisional; Region: PRK04164
298654004101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654004102	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654004103	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654004104	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
298654004105	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
298654004106	ATP phosphoribosyltransferase; Region: HisG; cl15266
298654004107	RibD C-terminal domain; Region: RibD_C; pfam01872
298654004108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654004109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004110	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654004111	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
298654004112	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654004113	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654004114	Methyltransferase domain; Region: Methyltransf_11; pfam08241
298654004115	Helix-turn-helix domain; Region: HTH_18; pfam12833
298654004116	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654004117	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654004118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654004119	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
298654004120	Strictosidine synthase; Region: Str_synth; pfam03088
298654004121	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654004122	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004123	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
298654004124	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
298654004125	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654004126	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654004127	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298654004128	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654004129	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
298654004130	CGNR zinc finger; Region: zf-CGNR; pfam11706
298654004131	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298654004132	EamA-like transporter family; Region: EamA; pfam00892
298654004133	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
298654004134	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654004135	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654004136	acyl-activating enzyme (AAE) consensus motif; other site
298654004137	putative AMP binding site [chemical binding]; other site
298654004138	putative active site [active]
298654004139	putative CoA binding site [chemical binding]; other site
298654004140	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
298654004141	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
298654004142	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
298654004143	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
298654004144	catalytic residues [active]
298654004145	catalytic nucleophile [active]
298654004146	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654004147	Helix-turn-helix domain; Region: HTH_31; pfam13560
298654004148	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
298654004149	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654004150	active site
298654004151	2-phosphoglycerate kinase; Provisional; Region: PRK12339
298654004152	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG1665
298654004153	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
298654004154	active site
298654004155	dimerization interface [polypeptide binding]; other site
298654004156	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654004157	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
298654004158	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654004159	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654004160	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654004161	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654004162	putative DNA binding site [nucleotide binding]; other site
298654004163	putative Zn2+ binding site [ion binding]; other site
298654004164	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
298654004165	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
298654004166	oligomeric interface; other site
298654004167	putative active site [active]
298654004168	homodimer interface [polypeptide binding]; other site
298654004169	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298654004170	dimer interface [polypeptide binding]; other site
298654004171	ADP-ribose binding site [chemical binding]; other site
298654004172	active site
298654004173	nudix motif; other site
298654004174	metal binding site [ion binding]; metal-binding site
298654004175	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
298654004176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654004177	FeS/SAM binding site; other site
298654004178	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
298654004179	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
298654004180	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654004181	substrate binding site [chemical binding]; other site
298654004182	activation loop (A-loop); other site
298654004183	AAA ATPase domain; Region: AAA_16; pfam13191
298654004184	Predicted ATPase [General function prediction only]; Region: COG3899
298654004185	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654004186	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654004187	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654004188	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654004189	metal binding site [ion binding]; metal-binding site
298654004190	active site
298654004191	I-site; other site
298654004192	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654004193	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654004194	active site
298654004195	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
298654004196	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654004197	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654004198	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
298654004199	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654004200	carboxyltransferase (CT) interaction site; other site
298654004201	biotinylation site [posttranslational modification]; other site
298654004202	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
298654004203	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298654004204	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
298654004205	prolyl-tRNA synthetase; Provisional; Region: PRK09194
298654004206	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
298654004207	dimer interface [polypeptide binding]; other site
298654004208	motif 1; other site
298654004209	active site
298654004210	motif 2; other site
298654004211	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
298654004212	putative deacylase active site [active]
298654004213	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298654004214	active site
298654004215	motif 3; other site
298654004216	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
298654004217	anticodon binding site; other site
298654004218	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
298654004219	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654004220	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654004221	substrate binding site [chemical binding]; other site
298654004222	oxyanion hole (OAH) forming residues; other site
298654004223	trimer interface [polypeptide binding]; other site
298654004224	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654004225	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654004226	Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441
298654004227	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654004228	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654004229	active site
298654004230	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654004231	active site
298654004232	oxyanion hole [active]
298654004233	catalytic triad [active]
298654004234	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654004235	active site
298654004236	oxyanion hole [active]
298654004237	catalytic triad [active]
298654004238	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
298654004239	catalytic triad [active]
298654004240	dimer interface [polypeptide binding]; other site
298654004241	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654004242	putative Zn2+ binding site [ion binding]; other site
298654004243	putative DNA binding site [nucleotide binding]; other site
298654004244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654004245	Coenzyme A binding pocket [chemical binding]; other site
298654004246	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
298654004247	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654004248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654004249	putative substrate translocation pore; other site
298654004250	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654004251	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
298654004252	DNA binding residues [nucleotide binding]
298654004253	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654004254	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654004255	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654004256	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
298654004257	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
298654004258	FAD binding pocket [chemical binding]; other site
298654004259	FAD binding motif [chemical binding]; other site
298654004260	phosphate binding motif [ion binding]; other site
298654004261	NAD binding pocket [chemical binding]; other site
298654004262	Helix-turn-helix domain; Region: HTH_17; cl17695
298654004263	Domain of unknown function (DUF202); Region: DUF202; cl09954
298654004264	Domain of unknown function (DUF202); Region: DUF202; cl09954
298654004265	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
298654004266	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654004267	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654004268	active site
298654004269	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
298654004270	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
298654004271	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654004272	active site
298654004273	HIGH motif; other site
298654004274	nucleotide binding site [chemical binding]; other site
298654004275	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654004276	active site
298654004277	KMSKS motif; other site
298654004278	Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327
298654004279	PaaX-like protein; Region: PaaX; pfam07848
298654004280	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
298654004281	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654004282	Walker A motif; other site
298654004283	ATP binding site [chemical binding]; other site
298654004284	Walker B motif; other site
298654004285	arginine finger; other site
298654004286	recombination factor protein RarA; Reviewed; Region: PRK13342
298654004287	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
298654004288	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
298654004289	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
298654004290	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
298654004291	motif 1; other site
298654004292	active site
298654004293	motif 2; other site
298654004294	motif 3; other site
298654004295	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
298654004296	DHHA1 domain; Region: DHHA1; pfam02272
298654004297	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
298654004298	YceG-like family; Region: YceG; pfam02618
298654004299	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
298654004300	dimerization interface [polypeptide binding]; other site
298654004301	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
298654004302	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
298654004303	YceG-like family; Region: YceG; pfam02618
298654004304	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
298654004305	dimerization interface [polypeptide binding]; other site
298654004306	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
298654004307	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
298654004308	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
298654004309	Tetramer interface [polypeptide binding]; other site
298654004310	active site
298654004311	FMN-binding site [chemical binding]; other site
298654004312	shikimate kinase; Reviewed; Region: aroK; PRK00131
298654004313	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
298654004314	ADP binding site [chemical binding]; other site
298654004315	magnesium binding site [ion binding]; other site
298654004316	putative shikimate binding site; other site
298654004317	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
298654004318	dimer interface [polypeptide binding]; other site
298654004319	active site
298654004320	metal binding site [ion binding]; metal-binding site
298654004321	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
298654004322	Dehydroquinase class II; Region: DHquinase_II; pfam01220
298654004323	trimer interface [polypeptide binding]; other site
298654004324	active site
298654004325	dimer interface [polypeptide binding]; other site
298654004326	elongation factor P; Validated; Region: PRK00529
298654004327	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
298654004328	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
298654004329	RNA binding site [nucleotide binding]; other site
298654004330	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
298654004331	RNA binding site [nucleotide binding]; other site
298654004332	transcription antitermination factor NusB; Region: nusB; TIGR01951
298654004333	putative RNA binding site [nucleotide binding]; other site
298654004334	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654004335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654004336	non-specific DNA binding site [nucleotide binding]; other site
298654004337	salt bridge; other site
298654004338	sequence-specific DNA binding site [nucleotide binding]; other site
298654004339	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
298654004340	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654004341	active site
298654004342	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
298654004343	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298654004344	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298654004345	dihydroorotase; Validated; Region: pyrC; PRK09357
298654004346	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654004347	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
298654004348	active site
298654004349	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
298654004350	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
298654004351	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
298654004352	catalytic site [active]
298654004353	subunit interface [polypeptide binding]; other site
298654004354	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
298654004355	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654004356	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
298654004357	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
298654004358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654004359	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654004360	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
298654004361	IMP binding site; other site
298654004362	dimer interface [polypeptide binding]; other site
298654004363	interdomain contacts; other site
298654004364	partial ornithine binding site; other site
298654004365	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
298654004366	active site
298654004367	dimer interface [polypeptide binding]; other site
298654004368	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
298654004369	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
298654004370	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
298654004371	catalytic site [active]
298654004372	G-X2-G-X-G-K; other site
298654004373	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
298654004374	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
298654004375	Flavoprotein; Region: Flavoprotein; pfam02441
298654004376	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
298654004377	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
298654004378	S-adenosylmethionine synthetase; Validated; Region: PRK05250
298654004379	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
298654004380	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
298654004381	primosome assembly protein PriA; Provisional; Region: PRK14873
298654004382	16S rRNA methyltransferase B; Provisional; Region: PRK14902
298654004383	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
298654004384	putative RNA binding site [nucleotide binding]; other site
298654004385	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
298654004386	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
298654004387	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
298654004388	putative active site [active]
298654004389	substrate binding site [chemical binding]; other site
298654004390	putative cosubstrate binding site; other site
298654004391	catalytic site [active]
298654004392	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
298654004393	substrate binding site [chemical binding]; other site
298654004394	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
298654004395	active site
298654004396	catalytic residues [active]
298654004397	metal binding site [ion binding]; metal-binding site
298654004398	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
298654004399	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
298654004400	substrate binding site [chemical binding]; other site
298654004401	hexamer interface [polypeptide binding]; other site
298654004402	metal binding site [ion binding]; metal-binding site
298654004403	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
298654004404	catalytic motif [active]
298654004405	Zn binding site [ion binding]; other site
298654004406	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
298654004407	Lumazine binding domain; Region: Lum_binding; pfam00677
298654004408	Lumazine binding domain; Region: Lum_binding; pfam00677
298654004409	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
298654004410	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
298654004411	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
298654004412	dimerization interface [polypeptide binding]; other site
298654004413	active site
298654004414	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
298654004415	homopentamer interface [polypeptide binding]; other site
298654004416	active site
298654004417	AAA domain; Region: AAA_31; pfam13614
298654004418	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
298654004419	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
298654004420	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
298654004421	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
298654004422	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
298654004423	23S rRNA binding site [nucleotide binding]; other site
298654004424	L21 binding site [polypeptide binding]; other site
298654004425	L13 binding site [polypeptide binding]; other site
298654004426	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
298654004427	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
298654004428	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
298654004429	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
298654004430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654004431	dimer interface [polypeptide binding]; other site
298654004432	phosphorylation site [posttranslational modification]
298654004433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654004434	ATP binding site [chemical binding]; other site
298654004435	Mg2+ binding site [ion binding]; other site
298654004436	G-X-G motif; other site
298654004437	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
298654004438	phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468
298654004439	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
298654004440	dimer interface [polypeptide binding]; other site
298654004441	motif 1; other site
298654004442	active site
298654004443	motif 2; other site
298654004444	motif 3; other site
298654004445	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
298654004446	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
298654004447	putative tRNA-binding site [nucleotide binding]; other site
298654004448	B3/4 domain; Region: B3_4; pfam03483
298654004449	tRNA synthetase B5 domain; Region: B5; smart00874
298654004450	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
298654004451	dimer interface [polypeptide binding]; other site
298654004452	motif 1; other site
298654004453	motif 3; other site
298654004454	motif 2; other site
298654004455	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
298654004456	hypothetical protein; Provisional; Region: PRK05409
298654004457	glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216
298654004458	substrate binding pocket [chemical binding]; other site
298654004459	catalytic residues [active]
298654004460	Cellulose binding domain; Region: CBM_2; pfam00553
298654004461	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
298654004462	active site
298654004463	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
298654004464	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298654004465	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
298654004466	heterotetramer interface [polypeptide binding]; other site
298654004467	active site pocket [active]
298654004468	cleavage site
298654004469	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
298654004470	feedback inhibition sensing region; other site
298654004471	homohexameric interface [polypeptide binding]; other site
298654004472	nucleotide binding site [chemical binding]; other site
298654004473	N-acetyl-L-glutamate binding site [chemical binding]; other site
298654004474	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
298654004475	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654004476	inhibitor-cofactor binding pocket; inhibition site
298654004477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654004478	catalytic residue [active]
298654004479	ornithine carbamoyltransferase; Provisional; Region: PRK00779
298654004480	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298654004481	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298654004482	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
298654004483	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
298654004484	argininosuccinate lyase; Provisional; Region: PRK00855
298654004485	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
298654004486	active sites [active]
298654004487	tetramer interface [polypeptide binding]; other site
298654004488	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
298654004489	active site
298654004490	DNA binding site [nucleotide binding]
298654004491	argininosuccinate synthase; Provisional; Region: PRK13820
298654004492	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
298654004493	Ligand Binding Site [chemical binding]; other site
298654004494	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
298654004495	Uncharacterized conserved protein [Function unknown]; Region: COG4198
298654004496	Tetratricopeptide repeat; Region: TPR_16; pfam13432
298654004497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
298654004498	TPR motif; other site
298654004499	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
298654004500	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
298654004501	SCP-2 sterol transfer family; Region: SCP2; cl01225
298654004502	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
298654004503	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
298654004504	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
298654004505	ATP-NAD kinase; Region: NAD_kinase; pfam01513
298654004506	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
298654004507	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
298654004508	Walker A/P-loop; other site
298654004509	ATP binding site [chemical binding]; other site
298654004510	Q-loop/lid; other site
298654004511	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
298654004512	ABC transporter signature motif; other site
298654004513	Walker B; other site
298654004514	D-loop; other site
298654004515	H-loop/switch region; other site
298654004516	CTP synthetase; Validated; Region: pyrG; PRK05380
298654004517	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
298654004518	Catalytic site [active]
298654004519	active site
298654004520	UTP binding site [chemical binding]; other site
298654004521	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
298654004522	active site
298654004523	putative oxyanion hole; other site
298654004524	catalytic triad [active]
298654004525	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298654004526	dimer interface [polypeptide binding]; other site
298654004527	active site
298654004528	ADP-ribose binding site [chemical binding]; other site
298654004529	nudix motif; other site
298654004530	metal binding site [ion binding]; metal-binding site
298654004531	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
298654004532	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654004533	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654004534	active site
298654004535	DNA binding site [nucleotide binding]
298654004536	Int/Topo IB signature motif; other site
298654004537	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
298654004538	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
298654004539	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
298654004540	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
298654004541	intersubunit interface [polypeptide binding]; other site
298654004542	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
298654004543	oligomerization interface [polypeptide binding]; other site
298654004544	active site
298654004545	metal binding site [ion binding]; metal-binding site
298654004546	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654004547	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004548	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
298654004549	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
298654004550	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
298654004551	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
298654004552	active site
298654004553	dimer interface [polypeptide binding]; other site
298654004554	motif 1; other site
298654004555	motif 2; other site
298654004556	motif 3; other site
298654004557	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
298654004558	anticodon binding site; other site
298654004559	NAD synthetase; Provisional; Region: PRK13981
298654004560	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
298654004561	multimer interface [polypeptide binding]; other site
298654004562	active site
298654004563	catalytic triad [active]
298654004564	protein interface 1 [polypeptide binding]; other site
298654004565	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
298654004566	homodimer interface [polypeptide binding]; other site
298654004567	NAD binding pocket [chemical binding]; other site
298654004568	ATP binding pocket [chemical binding]; other site
298654004569	Mg binding site [ion binding]; other site
298654004570	active-site loop [active]
298654004571	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
298654004572	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
298654004573	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298654004574	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
298654004575	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298654004576	metal binding triad; other site
298654004577	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
298654004578	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
298654004579	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298654004580	metal binding triad; other site
298654004581	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
298654004582	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
298654004583	glutamine synthetase; Region: PLN02284
298654004584	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298654004585	glutamine synthetase, type I; Region: GlnA; TIGR00653
298654004586	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
298654004587	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298654004588	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
298654004589	lipoyl synthase; Provisional; Region: PRK05481
298654004590	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654004591	FeS/SAM binding site; other site
298654004592	lipoate-protein ligase B; Provisional; Region: PRK14345
298654004593	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
298654004594	active site pocket [active]
298654004595	oxyanion hole [active]
298654004596	catalytic triad [active]
298654004597	active site nucleophile [active]
298654004598	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654004599	ATP binding site [chemical binding]; other site
298654004600	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298654004601	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
298654004602	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654004603	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298654004604	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654004605	DNA binding residues [nucleotide binding]
298654004606	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654004607	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
298654004608	NAD(P) binding site [chemical binding]; other site
298654004609	active site
298654004610	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654004611	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654004612	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654004613	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654004614	TM-ABC transporter signature motif; other site
298654004615	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654004616	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654004617	TM-ABC transporter signature motif; other site
298654004618	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654004619	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654004620	Walker A/P-loop; other site
298654004621	ATP binding site [chemical binding]; other site
298654004622	Q-loop/lid; other site
298654004623	ABC transporter signature motif; other site
298654004624	Walker B; other site
298654004625	D-loop; other site
298654004626	H-loop/switch region; other site
298654004627	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654004628	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654004629	Walker A/P-loop; other site
298654004630	ATP binding site [chemical binding]; other site
298654004631	Q-loop/lid; other site
298654004632	ABC transporter signature motif; other site
298654004633	Walker B; other site
298654004634	D-loop; other site
298654004635	H-loop/switch region; other site
298654004636	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654004637	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654004638	active site
298654004639	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
298654004640	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298654004641	E3 interaction surface; other site
298654004642	lipoyl attachment site [posttranslational modification]; other site
298654004643	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
298654004644	e3 binding domain; Region: E3_binding; pfam02817
298654004645	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298654004646	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
298654004647	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654004648	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298654004649	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
298654004650	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
298654004651	multifunctional aminopeptidase A; Provisional; Region: PRK00913
298654004652	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
298654004653	interface (dimer of trimers) [polypeptide binding]; other site
298654004654	Substrate-binding/catalytic site; other site
298654004655	Zn-binding sites [ion binding]; other site
298654004656	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
298654004657	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
298654004658	putative dimer interface [polypeptide binding]; other site
298654004659	active site pocket [active]
298654004660	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
298654004661	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654004662	structural tetrad; other site
298654004663	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654004664	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654004665	structural tetrad; other site
298654004666	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654004667	Domain of unknown function (DUF385); Region: DUF385; cl04387
298654004668	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654004669	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654004670	active site
298654004671	catalytic tetrad [active]
298654004672	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
298654004673	quinolinate synthetase; Provisional; Region: PRK09375
298654004674	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
298654004675	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298654004676	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
298654004677	substrate binding site [chemical binding]; other site
298654004678	ATP binding site [chemical binding]; other site
298654004679	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
298654004680	CPxP  motif; other site
298654004681	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654004682	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
298654004683	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654004684	catalytic residue [active]
298654004685	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
298654004686	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
298654004687	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
298654004688	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
298654004689	D-pathway; other site
298654004690	Putative ubiquinol binding site [chemical binding]; other site
298654004691	Low-spin heme (heme b) binding site [chemical binding]; other site
298654004692	Putative water exit pathway; other site
298654004693	Binuclear center (heme o3/CuB) [ion binding]; other site
298654004694	K-pathway; other site
298654004695	Putative proton exit pathway; other site
298654004696	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
298654004697	PemK-like protein; Region: PemK; pfam02452
298654004698	Protein of unknown function (DUF3501); Region: DUF3501; pfam12007
298654004699	Rubrerythrin [Energy production and conversion]; Region: COG1592
298654004700	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
298654004701	binuclear metal center [ion binding]; other site
298654004702	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
298654004703	metal binding site 2 [ion binding]; metal-binding site
298654004704	putative DNA binding helix; other site
298654004705	metal binding site 1 [ion binding]; metal-binding site
298654004706	dimer interface [polypeptide binding]; other site
298654004707	structural Zn2+ binding site [ion binding]; other site
298654004708	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
298654004709	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
298654004710	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
298654004711	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
298654004712	Cytochrome c; Region: Cytochrom_C; pfam00034
298654004713	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
298654004714	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
298654004715	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
298654004716	iron-sulfur cluster [ion binding]; other site
298654004717	[2Fe-2S] cluster binding site [ion binding]; other site
298654004718	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
298654004719	interchain domain interface [polypeptide binding]; other site
298654004720	heme bL binding site [chemical binding]; other site
298654004721	intrachain domain interface; other site
298654004722	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
298654004723	heme bH binding site [chemical binding]; other site
298654004724	Qo binding site; other site
298654004725	hypothetical protein; Validated; Region: PRK07883
298654004726	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
298654004727	active site
298654004728	catalytic site [active]
298654004729	substrate binding site [chemical binding]; other site
298654004730	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
298654004731	GIY-YIG motif/motif A; other site
298654004732	active site
298654004733	catalytic site [active]
298654004734	putative DNA binding site [nucleotide binding]; other site
298654004735	metal binding site [ion binding]; metal-binding site
298654004736	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
298654004737	active site
298654004738	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
298654004739	nucleotide binding site/active site [active]
298654004740	HIT family signature motif; other site
298654004741	catalytic residue [active]
298654004742	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
298654004743	YacP-like NYN domain; Region: NYN_YacP; cl01491
298654004744	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
298654004745	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654004746	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654004747	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
298654004748	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298654004749	nucleotide binding site [chemical binding]; other site
298654004750	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
298654004751	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
298654004752	DTAP/Switch II; other site
298654004753	Switch I; other site
298654004754	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
298654004755	putative hydrophobic ligand binding site [chemical binding]; other site
298654004756	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654004757	active site
298654004758	metal binding site [ion binding]; metal-binding site
298654004759	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
298654004760	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654004761	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
298654004762	acyl-activating enzyme (AAE) consensus motif; other site
298654004763	putative AMP binding site [chemical binding]; other site
298654004764	putative active site [active]
298654004765	putative CoA binding site [chemical binding]; other site
298654004766	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298654004767	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298654004768	putative acyl-acceptor binding pocket; other site
298654004769	Esterase/lipase [General function prediction only]; Region: COG1647
298654004770	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
298654004771	Uncharacterized conserved protein [Function unknown]; Region: COG1915
298654004772	homodimer interface [polypeptide binding]; other site
298654004773	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
298654004774	catalytic site [active]
298654004775	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
298654004776	phosphofructokinase; Region: PFK_mixed; TIGR02483
298654004777	active site
298654004778	ADP/pyrophosphate binding site [chemical binding]; other site
298654004779	dimerization interface [polypeptide binding]; other site
298654004780	allosteric effector site; other site
298654004781	fructose-1,6-bisphosphate binding site; other site
298654004782	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
298654004783	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654004784	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654004785	active site
298654004786	ATP binding site [chemical binding]; other site
298654004787	substrate binding site [chemical binding]; other site
298654004788	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654004789	substrate binding site [chemical binding]; other site
298654004790	activation loop (A-loop); other site
298654004791	activation loop (A-loop); other site
298654004792	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654004793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
298654004794	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654004795	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654004796	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654004797	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298654004798	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298654004799	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
298654004800	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654004801	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654004802	thiazole synthase; Reviewed; Region: thiG; PRK00208
298654004803	phosphate binding site [ion binding]; other site
298654004804	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
298654004805	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
298654004806	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
298654004807	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654004808	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298654004809	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298654004810	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
298654004811	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654004812	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
298654004813	thiS-thiF/thiG interaction site; other site
298654004814	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
298654004815	thiamine phosphate binding site [chemical binding]; other site
298654004816	active site
298654004817	pyrophosphate binding site [ion binding]; other site
298654004818	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
298654004819	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
298654004820	short chain dehydrogenase; Provisional; Region: PRK07791
298654004821	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
298654004822	homodimer interface [polypeptide binding]; other site
298654004823	NAD binding site [chemical binding]; other site
298654004824	active site
298654004825	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654004826	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654004827	active site
298654004828	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654004829	active site 2 [active]
298654004830	active site 1 [active]
298654004831	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
298654004832	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654004833	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654004834	putative metal binding site [ion binding]; other site
298654004835	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
298654004836	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
298654004837	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298654004838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654004839	motif II; other site
298654004840	CoA binding domain; Region: CoA_binding_2; pfam13380
298654004841	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
298654004842	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
298654004843	dimer interface [polypeptide binding]; other site
298654004844	TPP-binding site [chemical binding]; other site
298654004845	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
298654004846	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
298654004847	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
298654004848	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
298654004849	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654004850	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
298654004851	dimer interface [polypeptide binding]; other site
298654004852	catalytic triad [active]
298654004853	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
298654004854	AAA domain; Region: AAA_14; pfam13173
298654004855	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
298654004856	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654004857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654004858	non-specific DNA binding site [nucleotide binding]; other site
298654004859	salt bridge; other site
298654004860	sequence-specific DNA binding site [nucleotide binding]; other site
298654004861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654004862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004863	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
298654004864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654004865	NAD(P) binding site [chemical binding]; other site
298654004866	active site
298654004867	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654004868	active site
298654004869	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654004870	dimerization interface [polypeptide binding]; other site
298654004871	putative DNA binding site [nucleotide binding]; other site
298654004872	putative Zn2+ binding site [ion binding]; other site
298654004873	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654004874	hydrophobic ligand binding site; other site
298654004875	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654004876	Cytochrome P450; Region: p450; cl12078
298654004877	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654004878	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654004879	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654004880	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
298654004881	putative NAD(P) binding site [chemical binding]; other site
298654004882	Copper resistance protein D; Region: CopD; pfam05425
298654004883	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
298654004884	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
298654004885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
298654004886	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
298654004887	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654004888	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654004889	DNA binding residues [nucleotide binding]
298654004890	dimerization interface [polypeptide binding]; other site
298654004891	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654004892	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654004893	DNA binding residues [nucleotide binding]
298654004894	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654004895	Cytochrome P450; Region: p450; cl12078
298654004896	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298654004897	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654004898	active site
298654004899	phosphorylation site [posttranslational modification]
298654004900	intermolecular recognition site; other site
298654004901	dimerization interface [polypeptide binding]; other site
298654004902	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654004903	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654004904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654004905	active site
298654004906	phosphorylation site [posttranslational modification]
298654004907	intermolecular recognition site; other site
298654004908	dimerization interface [polypeptide binding]; other site
298654004909	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654004910	DNA binding residues [nucleotide binding]
298654004911	dimerization interface [polypeptide binding]; other site
298654004912	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654004913	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654004914	ATP binding site [chemical binding]; other site
298654004915	G-X-G motif; other site
298654004916	PspC domain; Region: PspC; pfam04024
298654004917	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
298654004918	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
298654004919	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298654004920	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298654004921	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298654004922	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654004923	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654004924	active site
298654004925	ATP binding site [chemical binding]; other site
298654004926	substrate binding site [chemical binding]; other site
298654004927	activation loop (A-loop); other site
298654004928	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
298654004929	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
298654004930	nudix motif; other site
298654004931	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
298654004932	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
298654004933	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
298654004934	NAD binding site [chemical binding]; other site
298654004935	substrate binding site [chemical binding]; other site
298654004936	catalytic Zn binding site [ion binding]; other site
298654004937	structural Zn binding site [ion binding]; other site
298654004938	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654004939	AMP-binding enzyme; Region: AMP-binding; pfam00501
298654004940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654004941	acyl-activating enzyme (AAE) consensus motif; other site
298654004942	AMP binding site [chemical binding]; other site
298654004943	active site
298654004944	CoA binding site [chemical binding]; other site
298654004945	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
298654004946	active site
298654004947	catalytic residues [active]
298654004948	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
298654004949	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654004950	DNA-binding site [nucleotide binding]; DNA binding site
298654004951	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654004952	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654004953	homodimer interface [polypeptide binding]; other site
298654004954	catalytic residue [active]
298654004955	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
298654004956	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
298654004957	Putative cyclase; Region: Cyclase; pfam04199
298654004958	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
298654004959	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654004960	active site
298654004961	lipid-transfer protein; Provisional; Region: PRK07937
298654004962	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
298654004963	active site
298654004964	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654004965	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654004966	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654004967	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654004968	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654004969	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654004970	TM-ABC transporter signature motif; other site
298654004971	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654004972	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654004973	TM-ABC transporter signature motif; other site
298654004974	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654004975	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654004976	Walker A/P-loop; other site
298654004977	ATP binding site [chemical binding]; other site
298654004978	Q-loop/lid; other site
298654004979	ABC transporter signature motif; other site
298654004980	Walker B; other site
298654004981	D-loop; other site
298654004982	H-loop/switch region; other site
298654004983	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654004984	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654004985	Walker A/P-loop; other site
298654004986	ATP binding site [chemical binding]; other site
298654004987	Q-loop/lid; other site
298654004988	ABC transporter signature motif; other site
298654004989	Walker B; other site
298654004990	D-loop; other site
298654004991	H-loop/switch region; other site
298654004992	RNA polymerase sigma factor; Provisional; Region: PRK12518
298654004993	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
298654004994	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654004995	Peptidase family M48; Region: Peptidase_M48; cl12018
298654004996	Penicillinase repressor; Region: Pencillinase_R; cl17580
298654004997	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654004998	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654004999	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654005000	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
298654005001	FAD binding site [chemical binding]; other site
298654005002	substrate binding site [chemical binding]; other site
298654005003	catalytic base [active]
298654005004	short chain dehydrogenase; Provisional; Region: PRK07831
298654005005	classical (c) SDRs; Region: SDR_c; cd05233
298654005006	NAD(P) binding site [chemical binding]; other site
298654005007	active site
298654005008	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
298654005009	homotetrameric interface [polypeptide binding]; other site
298654005010	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005011	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005012	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298654005013	hypothetical protein; Provisional; Region: PRK07208
298654005014	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654005015	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654005016	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298654005017	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
298654005018	G3 box; other site
298654005019	Switch II region; other site
298654005020	G4 box; other site
298654005021	Protein of unknown function (DUF742); Region: DUF742; pfam05331
298654005022	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
298654005023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654005024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654005025	ATP binding site [chemical binding]; other site
298654005026	Mg2+ binding site [ion binding]; other site
298654005027	G-X-G motif; other site
298654005028	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654005029	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654005030	short chain dehydrogenase; Provisional; Region: PRK07791
298654005031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654005032	NAD(P) binding site [chemical binding]; other site
298654005033	active site
298654005034	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
298654005035	Coenzyme A transferase; Region: CoA_trans; cl17247
298654005036	Nitronate monooxygenase; Region: NMO; pfam03060
298654005037	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
298654005038	FMN binding site [chemical binding]; other site
298654005039	substrate binding site [chemical binding]; other site
298654005040	putative catalytic residue [active]
298654005041	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654005042	active site 2 [active]
298654005043	active site 1 [active]
298654005044	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654005045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654005046	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005048	Uncharacterized conserved protein [Function unknown]; Region: COG1543
298654005049	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
298654005050	active site
298654005051	substrate binding site [chemical binding]; other site
298654005052	catalytic site [active]
298654005053	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
298654005054	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654005055	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
298654005056	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654005057	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654005058	NAD(P) binding site [chemical binding]; other site
298654005059	catalytic residues [active]
298654005060	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
298654005061	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654005062	NAD binding site [chemical binding]; other site
298654005063	catalytic Zn binding site [ion binding]; other site
298654005064	substrate binding site [chemical binding]; other site
298654005065	structural Zn binding site [ion binding]; other site
298654005066	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
298654005067	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654005068	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654005069	active site
298654005070	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654005071	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654005072	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654005073	acyl-CoA synthetase; Validated; Region: PRK07798
298654005074	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654005075	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
298654005076	acyl-activating enzyme (AAE) consensus motif; other site
298654005077	putative AMP binding site [chemical binding]; other site
298654005078	putative active site [active]
298654005079	putative CoA binding site [chemical binding]; other site
298654005080	acyl-CoA synthetase; Validated; Region: PRK06188
298654005081	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654005082	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654005083	putative active site [active]
298654005084	putative CoA binding site [chemical binding]; other site
298654005085	putative AMP binding site [chemical binding]; other site
298654005086	Uncharacterized conserved protein [Function unknown]; Region: COG1359
298654005087	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654005088	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654005089	putative metal binding site [ion binding]; other site
298654005090	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654005091	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654005092	putative metal binding site [ion binding]; other site
298654005093	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654005094	phosphate binding site [ion binding]; other site
298654005095	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
298654005096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
298654005097	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298654005098	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
298654005099	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
298654005100	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
298654005101	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
298654005102	RNA binding site [nucleotide binding]; other site
298654005103	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654005104	Methyltransferase domain; Region: Methyltransf_11; pfam08241
298654005105	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654005106	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298654005107	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
298654005108	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
298654005109	trigger factor; Provisional; Region: tig; PRK01490
298654005110	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298654005111	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
298654005112	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
298654005113	Clp protease; Region: CLP_protease; pfam00574
298654005114	oligomer interface [polypeptide binding]; other site
298654005115	active site residues [active]
298654005116	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
298654005117	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
298654005118	oligomer interface [polypeptide binding]; other site
298654005119	active site residues [active]
298654005120	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
298654005121	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
298654005122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654005123	Walker A motif; other site
298654005124	ATP binding site [chemical binding]; other site
298654005125	Walker B motif; other site
298654005126	arginine finger; other site
298654005127	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
298654005128	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
298654005129	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654005130	CoenzymeA binding site [chemical binding]; other site
298654005131	subunit interaction site [polypeptide binding]; other site
298654005132	PHB binding site; other site
298654005133	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
298654005134	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298654005135	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
298654005136	active site
298654005137	multimer interface [polypeptide binding]; other site
298654005138	rod shape-determining protein MreB; Provisional; Region: PRK13927
298654005139	MreB and similar proteins; Region: MreB_like; cd10225
298654005140	nucleotide binding site [chemical binding]; other site
298654005141	Mg binding site [ion binding]; other site
298654005142	putative protofilament interaction site [polypeptide binding]; other site
298654005143	RodZ interaction site [polypeptide binding]; other site
298654005144	rod shape-determining protein MreC; Provisional; Region: PRK13922
298654005145	rod shape-determining protein MreC; Region: MreC; pfam04085
298654005146	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
298654005147	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
298654005148	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298654005149	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
298654005150	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
298654005151	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
298654005152	B12 binding site [chemical binding]; other site
298654005153	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654005154	FeS/SAM binding site; other site
298654005155	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
298654005156	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
298654005157	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
298654005158	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
298654005159	homodimer interface [polypeptide binding]; other site
298654005160	oligonucleotide binding site [chemical binding]; other site
298654005161	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
298654005162	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
298654005163	GTPase CgtA; Reviewed; Region: obgE; PRK12296
298654005164	GTP1/OBG; Region: GTP1_OBG; pfam01018
298654005165	Obg GTPase; Region: Obg; cd01898
298654005166	G1 box; other site
298654005167	GTP/Mg2+ binding site [chemical binding]; other site
298654005168	Switch I region; other site
298654005169	G2 box; other site
298654005170	G3 box; other site
298654005171	Switch II region; other site
298654005172	G4 box; other site
298654005173	G5 box; other site
298654005174	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
298654005175	gamma-glutamyl kinase; Provisional; Region: PRK05429
298654005176	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
298654005177	nucleotide binding site [chemical binding]; other site
298654005178	homotetrameric interface [polypeptide binding]; other site
298654005179	putative phosphate binding site [ion binding]; other site
298654005180	putative allosteric binding site; other site
298654005181	PUA domain; Region: PUA; pfam01472
298654005182	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
298654005183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654005184	Walker A/P-loop; other site
298654005185	ATP binding site [chemical binding]; other site
298654005186	Q-loop/lid; other site
298654005187	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
298654005188	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
298654005189	ABC transporter signature motif; other site
298654005190	Walker B; other site
298654005191	D-loop; other site
298654005192	H-loop/switch region; other site
298654005193	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
298654005194	active site
298654005195	metal binding site [ion binding]; metal-binding site
298654005196	DNA binding site [nucleotide binding]
298654005197	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654005198	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
298654005199	MMPL family; Region: MMPL; pfam03176
298654005200	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
298654005201	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
298654005202	putative catalytic cysteine [active]
298654005203	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298654005204	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654005205	active site
298654005206	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
298654005207	malate synthase A; Region: malate_syn_A; TIGR01344
298654005208	active site
298654005209	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654005210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654005211	Walker A motif; other site
298654005212	ATP binding site [chemical binding]; other site
298654005213	Walker B motif; other site
298654005214	arginine finger; other site
298654005215	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
298654005216	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
298654005217	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654005218	FeS/SAM binding site; other site
298654005219	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
298654005220	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
298654005221	phosphoglucomutase; Validated; Region: PRK07564
298654005222	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
298654005223	active site
298654005224	substrate binding site [chemical binding]; other site
298654005225	metal binding site [ion binding]; metal-binding site
298654005226	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
298654005227	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
298654005228	active site
298654005229	(T/H)XGH motif; other site
298654005230	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
298654005231	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654005232	catalytic core [active]
298654005233	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654005234	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654005235	active site
298654005236	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654005237	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005238	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005239	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654005240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654005241	S-adenosylmethionine binding site [chemical binding]; other site
298654005242	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
298654005243	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654005244	hypothetical protein; Provisional; Region: PRK06194
298654005245	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654005246	NAD(P) binding site [chemical binding]; other site
298654005247	active site
298654005248	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
298654005249	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
298654005250	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
298654005251	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
298654005252	helix-hairpin-helix signature motif; other site
298654005253	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654005254	MarR family; Region: MarR_2; cl17246
298654005255	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654005256	hydrophobic ligand binding site; other site
298654005257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654005258	PAS fold; Region: PAS_3; pfam08447
298654005259	putative active site [active]
298654005260	heme pocket [chemical binding]; other site
298654005261	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654005262	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654005263	Cytochrome P450; Region: p450; cl12078
298654005264	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
298654005265	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654005266	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
298654005267	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
298654005268	homodimer interface [polypeptide binding]; other site
298654005269	active site
298654005270	TDP-binding site; other site
298654005271	acceptor substrate-binding pocket; other site
298654005272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005274	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
298654005275	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
298654005276	dimer interface [polypeptide binding]; other site
298654005277	active site
298654005278	heme binding site [chemical binding]; other site
298654005279	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
298654005280	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
298654005281	metal binding site 2 [ion binding]; metal-binding site
298654005282	putative DNA binding helix; other site
298654005283	metal binding site 1 [ion binding]; metal-binding site
298654005284	dimer interface [polypeptide binding]; other site
298654005285	structural Zn2+ binding site [ion binding]; other site
298654005286	short chain dehydrogenase; Provisional; Region: PRK07890
298654005287	classical (c) SDRs; Region: SDR_c; cd05233
298654005288	NAD(P) binding site [chemical binding]; other site
298654005289	active site
298654005290	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
298654005291	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654005292	LysR substrate binding domain; Region: LysR_substrate; pfam03466
298654005293	dimerization interface [polypeptide binding]; other site
298654005294	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654005295	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298654005296	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
298654005297	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
298654005298	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
298654005299	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
298654005300	active site residue [active]
298654005301	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
298654005302	active site residue [active]
298654005303	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
298654005304	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
298654005305	dimer interface [polypeptide binding]; other site
298654005306	active site
298654005307	non-prolyl cis peptide bond; other site
298654005308	insertion regions; other site
298654005309	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
298654005310	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
298654005311	dimer interface [polypeptide binding]; other site
298654005312	active site
298654005313	non-prolyl cis peptide bond; other site
298654005314	insertion regions; other site
298654005315	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654005316	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654005317	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654005318	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
298654005319	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298654005320	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654005321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298654005322	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
298654005323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654005324	putative PBP binding loops; other site
298654005325	ABC-ATPase subunit interface; other site
298654005326	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
298654005327	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654005328	Walker A/P-loop; other site
298654005329	ATP binding site [chemical binding]; other site
298654005330	Q-loop/lid; other site
298654005331	ABC transporter signature motif; other site
298654005332	Walker B; other site
298654005333	D-loop; other site
298654005334	H-loop/switch region; other site
298654005335	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654005336	Walker A/P-loop; other site
298654005337	ATP binding site [chemical binding]; other site
298654005338	Q-loop/lid; other site
298654005339	ABC transporter signature motif; other site
298654005340	Walker B; other site
298654005341	D-loop; other site
298654005342	H-loop/switch region; other site
298654005343	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654005344	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654005345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654005346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654005347	Walker A/P-loop; other site
298654005348	ATP binding site [chemical binding]; other site
298654005349	Q-loop/lid; other site
298654005350	ABC transporter signature motif; other site
298654005351	Walker B; other site
298654005352	D-loop; other site
298654005353	H-loop/switch region; other site
298654005354	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654005355	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654005356	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654005357	Walker A/P-loop; other site
298654005358	ATP binding site [chemical binding]; other site
298654005359	Q-loop/lid; other site
298654005360	ABC transporter signature motif; other site
298654005361	Walker B; other site
298654005362	D-loop; other site
298654005363	H-loop/switch region; other site
298654005364	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
298654005365	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654005366	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
298654005367	ChaB; Region: ChaB; pfam06150
298654005368	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
298654005369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654005370	active site
298654005371	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654005372	catalytic tetrad [active]
298654005373	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654005374	dimerization interface [polypeptide binding]; other site
298654005375	putative DNA binding site [nucleotide binding]; other site
298654005376	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654005377	putative Zn2+ binding site [ion binding]; other site
298654005378	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
298654005379	putative hydrophobic ligand binding site [chemical binding]; other site
298654005380	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
298654005381	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
298654005382	tetramer interface [polypeptide binding]; other site
298654005383	heme binding pocket [chemical binding]; other site
298654005384	NADPH binding site [chemical binding]; other site
298654005385	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
298654005386	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
298654005387	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654005388	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005389	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005390	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654005391	Cytochrome P450; Region: p450; cl12078
298654005392	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
298654005393	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654005394	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
298654005395	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654005396	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654005397	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654005398	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
298654005399	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654005400	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298654005401	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298654005402	glycoprotein BALF4; Provisional; Region: PHA03231
298654005403	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
298654005404	Penicillinase repressor; Region: Pencillinase_R; pfam03965
298654005405	Peptidase family M48; Region: Peptidase_M48; cl12018
298654005406	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
298654005407	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
298654005408	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654005409	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654005410	active site
298654005411	catalytic tetrad [active]
298654005412	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005413	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654005414	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654005415	Cytochrome P450; Region: p450; cl12078
298654005416	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654005417	aminodeoxychorismate synthase; Provisional; Region: PRK07508
298654005418	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654005419	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
298654005420	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
298654005421	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
298654005422	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
298654005423	homodimer interface [polypeptide binding]; other site
298654005424	NADP binding site [chemical binding]; other site
298654005425	substrate binding site [chemical binding]; other site
298654005426	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
298654005427	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298654005428	Helix-turn-helix domain; Region: HTH_18; pfam12833
298654005429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654005430	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654005431	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654005432	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654005433	NAD(P) binding site [chemical binding]; other site
298654005434	active site
298654005435	Right handed beta helix region; Region: Beta_helix; pfam13229
298654005436	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654005437	MarR family; Region: MarR; pfam01047
298654005438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654005439	putative substrate translocation pore; other site
298654005440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654005441	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
298654005442	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
298654005443	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
298654005444	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
298654005445	nucleotide binding site/active site [active]
298654005446	HIT family signature motif; other site
298654005447	catalytic residue [active]
298654005448	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
298654005449	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
298654005450	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654005451	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654005452	ATP binding site [chemical binding]; other site
298654005453	Mg2+ binding site [ion binding]; other site
298654005454	G-X-G motif; other site
298654005455	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
298654005456	Protein of unknown function (DUF742); Region: DUF742; pfam05331
298654005457	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298654005458	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
298654005459	G2 box; other site
298654005460	Switch I region; other site
298654005461	G3 box; other site
298654005462	Switch II region; other site
298654005463	G4 box; other site
298654005464	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654005465	active site
298654005466	oxyanion hole [active]
298654005467	catalytic triad [active]
298654005468	Protein of unknown function (DUF456); Region: DUF456; pfam04306
298654005469	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
298654005470	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654005471	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654005472	putative ligand binding site [chemical binding]; other site
298654005473	DNA polymerase III subunit beta; Validated; Region: PRK07761
298654005474	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
298654005475	putative DNA binding surface [nucleotide binding]; other site
298654005476	dimer interface [polypeptide binding]; other site
298654005477	beta-clamp/clamp loader binding surface; other site
298654005478	beta-clamp/translesion DNA polymerase binding surface; other site
298654005479	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654005480	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654005481	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298654005482	dimerization interface [polypeptide binding]; other site
298654005483	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
298654005484	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
298654005485	putative Iron-sulfur protein interface [polypeptide binding]; other site
298654005486	proximal heme binding site [chemical binding]; other site
298654005487	distal heme binding site [chemical binding]; other site
298654005488	putative dimer interface [polypeptide binding]; other site
298654005489	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
298654005490	L-aspartate oxidase; Provisional; Region: PRK06175
298654005491	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
298654005492	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
298654005493	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
298654005494	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298654005495	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298654005496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654005497	Coenzyme A binding pocket [chemical binding]; other site
298654005498	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
298654005499	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298654005500	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
298654005501	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
298654005502	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
298654005503	aromatic arch; other site
298654005504	DCoH dimer interaction site [polypeptide binding]; other site
298654005505	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
298654005506	DCoH tetramer interaction site [polypeptide binding]; other site
298654005507	substrate binding site [chemical binding]; other site
298654005508	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
298654005509	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654005510	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654005511	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654005512	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654005513	active site
298654005514	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
298654005515	DNA binding site [nucleotide binding]
298654005516	active site
298654005517	Int/Topo IB signature motif; other site
298654005518	catalytic residues [active]
298654005519	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654005520	MarR family; Region: MarR; pfam01047
298654005521	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
298654005522	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
298654005523	DNA binding residues [nucleotide binding]
298654005524	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654005525	non-specific DNA binding site [nucleotide binding]; other site
298654005526	salt bridge; other site
298654005527	sequence-specific DNA binding site [nucleotide binding]; other site
298654005528	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005530	Cupin domain; Region: Cupin_2; cl17218
298654005531	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654005532	Cytochrome P450; Region: p450; cl12078
298654005533	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
298654005534	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654005535	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654005536	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654005537	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654005538	active site
298654005539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654005540	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654005541	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654005542	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654005543	[2Fe-2S] cluster binding site [ion binding]; other site
298654005544	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654005545	hydrophobic ligand binding site; other site
298654005546	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654005547	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654005548	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654005549	NAD(P) binding site [chemical binding]; other site
298654005550	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298654005551	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654005552	dimer interface [polypeptide binding]; other site
298654005553	active site
298654005554	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298654005555	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654005556	ligand binding site [chemical binding]; other site
298654005557	flexible hinge region; other site
298654005558	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
298654005559	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
298654005560	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654005561	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
298654005562	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
298654005563	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654005564	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654005565	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654005566	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654005567	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654005568	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654005569	Walker A motif; other site
298654005570	ATP binding site [chemical binding]; other site
298654005571	Walker B motif; other site
298654005572	arginine finger; other site
298654005573	TIR domain; Region: TIR_2; pfam13676
298654005574	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654005575	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654005576	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654005577	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
298654005578	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
298654005579	RHS Repeat; Region: RHS_repeat; pfam05593
298654005580	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
298654005581	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
298654005582	protein-splicing catalytic site; other site
298654005583	thioester formation/cholesterol transfer; other site
298654005584	Pretoxin HINT domain; Region: PT-HINT; pfam07591
298654005585	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654005586	FAD binding domain; Region: FAD_binding_4; pfam01565
298654005587	Berberine and berberine like; Region: BBE; pfam08031
298654005588	Uncharacterized conserved protein [Function unknown]; Region: COG3268
298654005589	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
298654005590	active site
298654005591	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
298654005592	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
298654005593	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
298654005594	Protein of unknown function DUF91; Region: DUF91; cl00709
298654005595	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cl01497
298654005596	active site
298654005597	DNA binding site [nucleotide binding]
298654005598	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
298654005599	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
298654005600	putative active site [active]
298654005601	putative metal binding site [ion binding]; other site
298654005602	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
298654005603	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
298654005604	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654005605	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
298654005606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005607	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654005608	MarR family; Region: MarR_2; pfam12802
298654005609	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654005610	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654005611	active site
298654005612	NACHT domain; Region: NACHT; pfam05729
298654005613	Lamin Tail Domain; Region: LTD; pfam00932
298654005614	SdiA-regulated; Region: SdiA-regulated; cd09971
298654005615	putative active site [active]
298654005616	RibD C-terminal domain; Region: RibD_C; cl17279
298654005617	Methyltransferase domain; Region: Methyltransf_31; pfam13847
298654005618	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654005619	S-adenosylmethionine binding site [chemical binding]; other site
298654005620	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
298654005621	RibD C-terminal domain; Region: RibD_C; cl17279
298654005622	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654005623	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654005624	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005626	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654005627	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654005628	active site
298654005629	ATP binding site [chemical binding]; other site
298654005630	substrate binding site [chemical binding]; other site
298654005631	activation loop (A-loop); other site
298654005632	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
298654005633	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654005634	DNA binding residues [nucleotide binding]
298654005635	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654005636	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654005637	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
298654005638	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654005639	Walker A/P-loop; other site
298654005640	ATP binding site [chemical binding]; other site
298654005641	Q-loop/lid; other site
298654005642	ABC transporter signature motif; other site
298654005643	Walker B; other site
298654005644	D-loop; other site
298654005645	H-loop/switch region; other site
298654005646	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005647	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005648	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654005649	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
298654005650	putative NAD(P) binding site [chemical binding]; other site
298654005651	catalytic Zn binding site [ion binding]; other site
298654005652	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654005653	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654005654	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
298654005655	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
298654005656	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
298654005657	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
298654005658	active site
298654005659	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
298654005660	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654005661	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
298654005662	YCII-related domain; Region: YCII; cl00999
298654005663	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
298654005664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654005665	DNA binding residues [nucleotide binding]
298654005666	RNA polymerase factor sigma-70; Validated; Region: PRK08241
298654005667	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654005668	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654005669	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
298654005670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
298654005671	MOSC domain; Region: MOSC; pfam03473
298654005672	3-alpha domain; Region: 3-alpha; pfam03475
298654005673	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
298654005674	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
298654005675	FAD binding pocket [chemical binding]; other site
298654005676	FAD binding motif [chemical binding]; other site
298654005677	phosphate binding motif [ion binding]; other site
298654005678	beta-alpha-beta structure motif; other site
298654005679	NAD binding pocket [chemical binding]; other site
298654005680	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654005681	catalytic loop [active]
298654005682	iron binding site [ion binding]; other site
298654005683	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005685	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654005686	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654005687	Cytochrome P450; Region: p450; cl12078
298654005688	K+ potassium transporter; Region: K_trans; cl15781
298654005689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654005690	putative substrate translocation pore; other site
298654005691	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654005692	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654005693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654005694	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
298654005695	Fatty acid desaturase; Region: FA_desaturase; pfam00487
298654005696	Di-iron ligands [ion binding]; other site
298654005697	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298654005698	adenosine deaminase; Provisional; Region: PRK09358
298654005699	active site
298654005700	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298654005701	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298654005702	putative acyl-acceptor binding pocket; other site
298654005703	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
298654005704	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
298654005705	Survival protein SurE; Region: SurE; cl00448
298654005706	Membrane transport protein; Region: Mem_trans; cl09117
298654005707	Uncharacterized conserved protein [Function unknown]; Region: COG2353
298654005708	SLBB domain; Region: SLBB; pfam10531
298654005709	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
298654005710	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
298654005711	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
298654005712	Competence protein; Region: Competence; pfam03772
298654005713	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
298654005714	hypothetical protein; Reviewed; Region: PRK07914
298654005715	GTP-binding protein LepA; Provisional; Region: PRK05433
298654005716	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
298654005717	G1 box; other site
298654005718	putative GEF interaction site [polypeptide binding]; other site
298654005719	GTP/Mg2+ binding site [chemical binding]; other site
298654005720	Switch I region; other site
298654005721	G2 box; other site
298654005722	G3 box; other site
298654005723	Switch II region; other site
298654005724	G4 box; other site
298654005725	G5 box; other site
298654005726	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
298654005727	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
298654005728	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
298654005729	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
298654005730	coproporphyrinogen III oxidase; Validated; Region: PRK05628
298654005731	HemN C-terminal domain; Region: HemN_C; pfam06969
298654005732	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
298654005733	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
298654005734	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
298654005735	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298654005736	HSP70 interaction site [polypeptide binding]; other site
298654005737	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
298654005738	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
298654005739	dimer interface [polypeptide binding]; other site
298654005740	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
298654005741	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
298654005742	PhoH-like protein; Region: PhoH; pfam02562
298654005743	metal-binding heat shock protein; Provisional; Region: PRK00016
298654005744	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
298654005745	Domain of unknown function DUF21; Region: DUF21; pfam01595
298654005746	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
298654005747	Transporter associated domain; Region: CorC_HlyC; smart01091
298654005748	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
298654005749	GTPase Era; Reviewed; Region: era; PRK00089
298654005750	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
298654005751	G1 box; other site
298654005752	GTP/Mg2+ binding site [chemical binding]; other site
298654005753	Switch I region; other site
298654005754	G2 box; other site
298654005755	Switch II region; other site
298654005756	G3 box; other site
298654005757	G4 box; other site
298654005758	G5 box; other site
298654005759	KH domain; Region: KH_2; pfam07650
298654005760	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
298654005761	Recombination protein O N terminal; Region: RecO_N; pfam11967
298654005762	Recombination protein O C terminal; Region: RecO_C; pfam02565
298654005763	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
298654005764	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
298654005765	catalytic residue [active]
298654005766	putative FPP diphosphate  binding site; other site
298654005767	putative FPP binding hydrophobic cleft; other site
298654005768	dimer interface [polypeptide binding]; other site
298654005769	putative IPP diphosphate binding site; other site
298654005770	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654005771	putative metal binding site [ion binding]; other site
298654005772	Restriction endonuclease; Region: Mrr_cat; pfam04471
298654005773	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298654005774	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
298654005775	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
298654005776	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654005777	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654005778	active site
298654005779	ATP binding site [chemical binding]; other site
298654005780	substrate binding site [chemical binding]; other site
298654005781	activation loop (A-loop); other site
298654005782	glycyl-tRNA synthetase; Provisional; Region: PRK04173
298654005783	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298654005784	motif 1; other site
298654005785	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
298654005786	dimer interface [polypeptide binding]; other site
298654005787	active site
298654005788	motif 2; other site
298654005789	motif 3; other site
298654005790	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
298654005791	anticodon binding site; other site
298654005792	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298654005793	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654005794	von Willebrand factor type A domain; Region: VWA_2; pfam13519
298654005795	metal ion-dependent adhesion site (MIDAS); other site
298654005796	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298654005797	putative active site [active]
298654005798	transketolase; Reviewed; Region: PRK05899
298654005799	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
298654005800	TPP-binding site [chemical binding]; other site
298654005801	dimer interface [polypeptide binding]; other site
298654005802	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
298654005803	PYR/PP interface [polypeptide binding]; other site
298654005804	dimer interface [polypeptide binding]; other site
298654005805	TPP binding site [chemical binding]; other site
298654005806	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654005807	Bacterial PH domain; Region: DUF304; pfam03703
298654005808	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
298654005809	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298654005810	Zn2+ binding site [ion binding]; other site
298654005811	Mg2+ binding site [ion binding]; other site
298654005812	DNA primase; Validated; Region: dnaG; PRK05667
298654005813	CHC2 zinc finger; Region: zf-CHC2; pfam01807
298654005814	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
298654005815	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
298654005816	active site
298654005817	metal binding site [ion binding]; metal-binding site
298654005818	interdomain interaction site; other site
298654005819	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
298654005820	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
298654005821	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
298654005822	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
298654005823	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298654005824	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654005825	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298654005826	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654005827	DNA binding residues [nucleotide binding]
298654005828	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654005829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
298654005830	intermolecular recognition site; other site
298654005831	active site
298654005832	dimerization interface [polypeptide binding]; other site
298654005833	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654005834	dimerization interface [polypeptide binding]; other site
298654005835	DNA binding residues [nucleotide binding]
298654005836	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654005837	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654005838	phosphopeptide binding site; other site
298654005839	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
298654005840	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654005841	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654005842	AAA domain; Region: AAA_22; pfam13401
298654005843	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
298654005844	Proteins of 100 residues with WXG; Region: WXG100; cl02005
298654005845	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654005846	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654005847	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
298654005848	active site
298654005849	catalytic site [active]
298654005850	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654005851	metal binding site [ion binding]; metal-binding site
298654005852	active site
298654005853	I-site; other site
298654005854	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654005855	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654005856	TIGR04222 domain; Region: near_uncomplex
298654005857	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654005858	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654005859	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
298654005860	acyl-activating enzyme (AAE) consensus motif; other site
298654005861	putative AMP binding site [chemical binding]; other site
298654005862	putative active site [active]
298654005863	putative CoA binding site [chemical binding]; other site
298654005864	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
298654005865	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654005866	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654005867	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
298654005868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654005869	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654005870	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654005871	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
298654005872	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298654005873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
298654005874	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
298654005875	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654005876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654005877	active site
298654005878	phosphorylation site [posttranslational modification]
298654005879	intermolecular recognition site; other site
298654005880	dimerization interface [polypeptide binding]; other site
298654005881	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654005882	DNA binding residues [nucleotide binding]
298654005883	dimerization interface [polypeptide binding]; other site
298654005884	Histidine kinase; Region: HisKA_3; pfam07730
298654005885	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654005886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654005887	TPR motif; other site
298654005888	binding surface
298654005889	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
298654005890	catalytic motif [active]
298654005891	Catalytic residue [active]
298654005892	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
298654005893	inhibitor binding site; inhibition site
298654005894	catalytic motif [active]
298654005895	Catalytic residue [active]
298654005896	Active site flap [active]
298654005897	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
298654005898	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
298654005899	NAD(P) binding site [chemical binding]; other site
298654005900	homodimer interface [polypeptide binding]; other site
298654005901	substrate binding site [chemical binding]; other site
298654005902	active site
298654005903	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
298654005904	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654005905	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654005906	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654005907	extended (e) SDRs; Region: SDR_e; cd08946
298654005908	NAD(P) binding site [chemical binding]; other site
298654005909	active site
298654005910	substrate binding site [chemical binding]; other site
298654005911	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
298654005912	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
298654005913	putative trimer interface [polypeptide binding]; other site
298654005914	putative CoA binding site [chemical binding]; other site
298654005915	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654005916	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654005917	extended (e) SDRs; Region: SDR_e; cd08946
298654005918	NAD(P) binding site [chemical binding]; other site
298654005919	active site
298654005920	substrate binding site [chemical binding]; other site
298654005921	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
298654005922	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
298654005923	Mg++ binding site [ion binding]; other site
298654005924	putative catalytic motif [active]
298654005925	putative substrate binding site [chemical binding]; other site
298654005926	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
298654005927	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
298654005928	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
298654005929	aconitate hydratase; Validated; Region: PRK09277
298654005930	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
298654005931	substrate binding site [chemical binding]; other site
298654005932	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
298654005933	ligand binding site [chemical binding]; other site
298654005934	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
298654005935	substrate binding site [chemical binding]; other site
298654005936	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
298654005937	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
298654005938	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
298654005939	active site
298654005940	dimerization interface [polypeptide binding]; other site
298654005941	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
298654005942	dinuclear metal binding motif [ion binding]; other site
298654005943	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
298654005944	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
298654005945	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654005946	active site
298654005947	HIGH motif; other site
298654005948	nucleotide binding site [chemical binding]; other site
298654005949	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654005950	active site
298654005951	KMSKS motif; other site
298654005952	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
298654005953	tRNA binding surface [nucleotide binding]; other site
298654005954	anticodon binding site; other site
298654005955	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
298654005956	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
298654005957	trimer interface [polypeptide binding]; other site
298654005958	putative metal binding site [ion binding]; other site
298654005959	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
298654005960	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
298654005961	trimer interface [polypeptide binding]; other site
298654005962	active site
298654005963	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
298654005964	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
298654005965	generic binding surface II; other site
298654005966	ssDNA binding site; other site
298654005967	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
298654005968	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
298654005969	TrkA-N domain; Region: TrkA_N; pfam02254
298654005970	TrkA-C domain; Region: TrkA_C; pfam02080
298654005971	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
298654005972	TrkA-N domain; Region: TrkA_N; pfam02254
298654005973	TrkA-C domain; Region: TrkA_C; pfam02080
298654005974	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
298654005975	TRAM domain; Region: TRAM; pfam01938
298654005976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654005977	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
298654005978	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
298654005979	TPP-binding site; other site
298654005980	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
298654005981	PYR/PP interface [polypeptide binding]; other site
298654005982	dimer interface [polypeptide binding]; other site
298654005983	TPP binding site [chemical binding]; other site
298654005984	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654005985	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
298654005986	Uncharacterized conserved protein [Function unknown]; Region: COG2898
298654005987	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
298654005988	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
298654005989	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654005990	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298654005991	ligand binding site [chemical binding]; other site
298654005992	flexible hinge region; other site
298654005993	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
298654005994	von Willebrand factor type A domain; Region: VWA_2; pfam13519
298654005995	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298654005996	ligand binding site [chemical binding]; other site
298654005997	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654005998	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
298654005999	substrate binding site [chemical binding]; other site
298654006000	oxyanion hole (OAH) forming residues; other site
298654006001	trimer interface [polypeptide binding]; other site
298654006002	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654006003	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654006004	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654006005	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
298654006006	dimer interface [polypeptide binding]; other site
298654006007	active site
298654006008	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298654006009	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298654006010	protein binding site [polypeptide binding]; other site
298654006011	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
298654006012	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
298654006013	catalytic site [active]
298654006014	putative active site [active]
298654006015	putative substrate binding site [chemical binding]; other site
298654006016	Helicase and RNase D C-terminal; Region: HRDC; smart00341
298654006017	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
298654006018	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
298654006019	substrate binding site [chemical binding]; other site
298654006020	active site
298654006021	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
298654006022	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
298654006023	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
298654006024	Bacterial sugar transferase; Region: Bac_transf; pfam02397
298654006025	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
298654006026	Divergent AAA domain; Region: AAA_4; pfam04326
298654006027	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
298654006028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654006030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654006031	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298654006032	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
298654006033	active site
298654006034	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654006035	Uncharacterized conserved protein [Function unknown]; Region: COG0393
298654006036	Uncharacterized conserved protein [Function unknown]; Region: COG0393
298654006037	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
298654006038	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
298654006039	active site
298654006040	DNA binding site [nucleotide binding]
298654006041	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
298654006042	DNA binding site [nucleotide binding]
298654006043	hypothetical protein; Provisional; Region: PRK14059
298654006044	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
298654006045	prephenate dehydratase; Provisional; Region: PRK11899
298654006046	Prephenate dehydratase; Region: PDT; pfam00800
298654006047	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
298654006048	putative L-Phe binding site [chemical binding]; other site
298654006049	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
298654006050	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
298654006051	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
298654006052	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
298654006053	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
298654006054	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
298654006055	catalytic site [active]
298654006056	active site
298654006057	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
298654006058	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
298654006059	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
298654006060	active site
298654006061	catalytic site [active]
298654006062	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
298654006063	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
298654006064	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
298654006065	active site
298654006066	catalytic site [active]
298654006067	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
298654006068	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
298654006069	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
298654006070	catalytic triad [active]
298654006071	conserved cis-peptide bond; other site
298654006072	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
298654006073	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
298654006074	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
298654006075	active site
298654006076	metal binding site [ion binding]; metal-binding site
298654006077	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298654006078	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654006079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654006080	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
298654006081	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
298654006082	nucleotide binding site/active site [active]
298654006083	HIT family signature motif; other site
298654006084	catalytic residue [active]
298654006085	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298654006086	elongation factor G; Reviewed; Region: PRK12740
298654006087	G1 box; other site
298654006088	GTP/Mg2+ binding site [chemical binding]; other site
298654006089	G2 box; other site
298654006090	Switch I region; other site
298654006091	G3 box; other site
298654006092	Switch II region; other site
298654006093	G4 box; other site
298654006094	G5 box; other site
298654006095	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
298654006096	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
298654006097	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
298654006098	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
298654006099	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
298654006100	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
298654006101	putative acyl-acceptor binding pocket; other site
298654006102	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654006103	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654006104	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
298654006105	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
298654006106	active site
298654006107	multimer interface [polypeptide binding]; other site
298654006108	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
298654006109	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143
298654006110	predicted active site [active]
298654006111	catalytic triad [active]
298654006112	hypothetical protein; Validated; Region: PRK00110
298654006113	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
298654006114	active site
298654006115	putative DNA-binding cleft [nucleotide binding]; other site
298654006116	dimer interface [polypeptide binding]; other site
298654006117	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
298654006118	RuvA N terminal domain; Region: RuvA_N; pfam01330
298654006119	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
298654006120	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
298654006121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654006122	Walker A motif; other site
298654006123	ATP binding site [chemical binding]; other site
298654006124	Walker B motif; other site
298654006125	arginine finger; other site
298654006126	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
298654006127	Preprotein translocase subunit; Region: YajC; pfam02699
298654006128	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
298654006129	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
298654006130	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
298654006131	Protein export membrane protein; Region: SecD_SecF; pfam02355
298654006132	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654006133	active site
298654006134	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
298654006135	HD domain; Region: HD_4; pfam13328
298654006136	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
298654006137	synthetase active site [active]
298654006138	NTP binding site [chemical binding]; other site
298654006139	metal binding site [ion binding]; metal-binding site
298654006140	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
298654006141	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
298654006142	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
298654006143	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298654006144	Zn2+ binding site [ion binding]; other site
298654006145	Mg2+ binding site [ion binding]; other site
298654006146	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
298654006147	synthetase active site [active]
298654006148	NTP binding site [chemical binding]; other site
298654006149	metal binding site [ion binding]; metal-binding site
298654006150	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
298654006151	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
298654006152	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
298654006153	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654006154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654006155	non-specific DNA binding site [nucleotide binding]; other site
298654006156	salt bridge; other site
298654006157	sequence-specific DNA binding site [nucleotide binding]; other site
298654006158	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
298654006159	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654006160	ATP binding site [chemical binding]; other site
298654006161	putative Mg++ binding site [ion binding]; other site
298654006162	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
298654006163	active site
298654006164	seryl-tRNA synthetase; Provisional; Region: PRK05431
298654006165	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
298654006166	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
298654006167	dimer interface [polypeptide binding]; other site
298654006168	active site
298654006169	motif 1; other site
298654006170	motif 2; other site
298654006171	motif 3; other site
298654006172	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
298654006173	active site lid residues [active]
298654006174	substrate binding pocket [chemical binding]; other site
298654006175	catalytic residues [active]
298654006176	substrate-Mg2+ binding site; other site
298654006177	aspartate-rich region 1; other site
298654006178	aspartate-rich region 2; other site
298654006179	von Willebrand factor type A domain; Region: VWA_2; pfam13519
298654006180	metal ion-dependent adhesion site (MIDAS); other site
298654006181	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654006182	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654006183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654006184	Walker A motif; other site
298654006185	ATP binding site [chemical binding]; other site
298654006186	Walker B motif; other site
298654006187	arginine finger; other site
298654006188	phytoene desaturase; Region: crtI_fam; TIGR02734
298654006189	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
298654006190	FAD binding site [chemical binding]; other site
298654006191	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
298654006192	phytoene desaturase; Region: crtI_fam; TIGR02734
298654006193	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
298654006194	active site
298654006195	Protein of unknown function (DUF422); Region: DUF422; cl00991
298654006196	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
298654006197	DNA Polymerase Y-family; Region: PolY_like; cd03468
298654006198	active site
298654006199	DNA binding site [nucleotide binding]
298654006200	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
298654006201	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
298654006202	active site
298654006203	PHP Thumb interface [polypeptide binding]; other site
298654006204	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
298654006205	generic binding surface II; other site
298654006206	generic binding surface I; other site
298654006207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654006208	DNA polymerase IV; Validated; Region: PRK03858
298654006209	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
298654006210	active site
298654006211	DNA binding site [nucleotide binding]
298654006212	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
298654006213	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654006214	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654006215	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654006216	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654006217	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654006218	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654006219	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654006220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654006221	Walker A motif; other site
298654006222	ATP binding site [chemical binding]; other site
298654006223	Walker B motif; other site
298654006224	arginine finger; other site
298654006225	cell division protein MraZ; Reviewed; Region: PRK00326
298654006226	MraZ protein; Region: MraZ; pfam02381
298654006227	MraZ protein; Region: MraZ; pfam02381
298654006228	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
298654006229	MraW methylase family; Region: Methyltransf_5; cl17771
298654006230	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
298654006231	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
298654006232	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298654006233	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
298654006234	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298654006235	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298654006236	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298654006237	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298654006238	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298654006239	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298654006240	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
298654006241	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
298654006242	Mg++ binding site [ion binding]; other site
298654006243	putative catalytic motif [active]
298654006244	putative substrate binding site [chemical binding]; other site
298654006245	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
298654006246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298654006247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298654006248	cell division protein FtsW; Region: ftsW; TIGR02614
298654006249	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
298654006250	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
298654006251	active site
298654006252	homodimer interface [polypeptide binding]; other site
298654006253	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
298654006254	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298654006255	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298654006256	cell division protein FtsZ; Validated; Region: PRK09330
298654006257	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
298654006258	nucleotide binding site [chemical binding]; other site
298654006259	SulA interaction site; other site
298654006260	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
298654006261	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
298654006262	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
298654006263	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298654006264	catalytic residue [active]
298654006265	Protein of unknown function (DUF552); Region: DUF552; pfam04472
298654006266	DivIVA protein; Region: DivIVA; pfam05103
298654006267	DivIVA domain; Region: DivI1A_domain; TIGR03544
298654006268	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
298654006269	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298654006270	RNA binding surface [nucleotide binding]; other site
298654006271	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
298654006272	active site
298654006273	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
298654006274	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
298654006275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654006276	S-adenosylmethionine binding site [chemical binding]; other site
298654006277	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
298654006278	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
298654006279	HIGH motif; other site
298654006280	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
298654006281	active site
298654006282	KMSKS motif; other site
298654006283	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
298654006284	tRNA binding surface [nucleotide binding]; other site
298654006285	anticodon binding site; other site
298654006286	PIN domain; Region: PIN; pfam01850
298654006287	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654006288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654006289	Walker A/P-loop; other site
298654006290	ATP binding site [chemical binding]; other site
298654006291	Q-loop/lid; other site
298654006292	ABC transporter signature motif; other site
298654006293	Walker B; other site
298654006294	D-loop; other site
298654006295	H-loop/switch region; other site
298654006296	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654006297	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654006298	putative metal binding site [ion binding]; other site
298654006299	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
298654006300	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
298654006301	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
298654006302	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
298654006303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654006304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654006305	active site
298654006306	phosphorylation site [posttranslational modification]
298654006307	intermolecular recognition site; other site
298654006308	dimerization interface [polypeptide binding]; other site
298654006309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654006310	DNA binding residues [nucleotide binding]
298654006311	dimerization interface [polypeptide binding]; other site
298654006312	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654006313	Histidine kinase; Region: HisKA_3; pfam07730
298654006314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654006315	ATP binding site [chemical binding]; other site
298654006316	Mg2+ binding site [ion binding]; other site
298654006317	G-X-G motif; other site
298654006318	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654006319	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654006320	Walker A/P-loop; other site
298654006321	ATP binding site [chemical binding]; other site
298654006322	Q-loop/lid; other site
298654006323	ABC transporter signature motif; other site
298654006324	Walker B; other site
298654006325	D-loop; other site
298654006326	H-loop/switch region; other site
298654006327	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654006328	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654006329	active site
298654006330	ATP binding site [chemical binding]; other site
298654006331	substrate binding site [chemical binding]; other site
298654006332	activation loop (A-loop); other site
298654006333	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
298654006334	active site
298654006335	NTP binding site [chemical binding]; other site
298654006336	metal binding triad [ion binding]; metal-binding site
298654006337	antibiotic binding site [chemical binding]; other site
298654006338	hypothetical protein; Provisional; Region: PRK07906
298654006339	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
298654006340	putative metal binding site [ion binding]; other site
298654006341	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298654006342	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654006343	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654006344	catalytic residue [active]
298654006345	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
298654006346	dimerization interface [polypeptide binding]; other site
298654006347	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
298654006348	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
298654006349	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
298654006350	active site
298654006351	TIGR02679 family protein; Region: TIGR02679
298654006352	Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664
298654006353	TIGR02680 family protein; Region: TIGR02680
298654006354	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
298654006355	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
298654006356	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
298654006357	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
298654006358	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
298654006359	ligand binding site [chemical binding]; other site
298654006360	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
298654006361	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654006362	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654006363	MarR family; Region: MarR; pfam01047
298654006364	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654006365	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
298654006366	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
298654006367	putative active site [active]
298654006368	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654006369	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654006370	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
298654006371	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
298654006372	putative ligand binding site [chemical binding]; other site
298654006373	putative NAD binding site [chemical binding]; other site
298654006374	catalytic site [active]
298654006375	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654006376	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
298654006377	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654006378	DNA binding residues [nucleotide binding]
298654006379	dimer interface [polypeptide binding]; other site
298654006380	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
298654006381	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654006382	sequence-specific DNA binding site [nucleotide binding]; other site
298654006383	salt bridge; other site
298654006384	Cupin domain; Region: Cupin_2; pfam07883
298654006385	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
298654006386	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654006387	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654006388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006389	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654006390	putative substrate translocation pore; other site
298654006391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006392	Domain of unknown function DUF87; Region: DUF87; pfam01935
298654006393	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654006394	Protein kinase domain; Region: Pkinase; pfam00069
298654006395	active site
298654006396	ATP binding site [chemical binding]; other site
298654006397	substrate binding site [chemical binding]; other site
298654006398	activation loop (A-loop); other site
298654006399	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
298654006400	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654006401	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
298654006402	active site
298654006403	ATP binding site [chemical binding]; other site
298654006404	substrate binding site [chemical binding]; other site
298654006405	activation loop (A-loop); other site
298654006406	L-lysine aminotransferase; Provisional; Region: PRK08297
298654006407	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654006408	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654006409	catalytic residue [active]
298654006410	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654006411	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654006412	NAD(P) binding site [chemical binding]; other site
298654006413	catalytic residues [active]
298654006414	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
298654006415	TIR domain; Region: TIR_2; pfam13676
298654006416	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
298654006417	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
298654006418	dimerization interface [polypeptide binding]; other site
298654006419	DPS ferroxidase diiron center [ion binding]; other site
298654006420	ion pore; other site
298654006421	FtsH Extracellular; Region: FtsH_ext; pfam06480
298654006422	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
298654006423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654006424	Walker A motif; other site
298654006425	ATP binding site [chemical binding]; other site
298654006426	Walker B motif; other site
298654006427	arginine finger; other site
298654006428	Peptidase family M41; Region: Peptidase_M41; pfam01434
298654006429	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
298654006430	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654006431	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
298654006432	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
298654006433	active site
298654006434	PHP Thumb interface [polypeptide binding]; other site
298654006435	metal binding site [ion binding]; metal-binding site
298654006436	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
298654006437	generic binding surface II; other site
298654006438	generic binding surface I; other site
298654006439	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298654006440	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298654006441	ATP binding site [chemical binding]; other site
298654006442	Mg++ binding site [ion binding]; other site
298654006443	motif III; other site
298654006444	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654006445	nucleotide binding region [chemical binding]; other site
298654006446	ATP-binding site [chemical binding]; other site
298654006447	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
298654006448	Protein of unknown function (DUF445); Region: DUF445; pfam04286
298654006449	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654006450	FAD binding domain; Region: FAD_binding_4; pfam01565
298654006451	Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129
298654006452	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
298654006453	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
298654006454	hexamer interface [polypeptide binding]; other site
298654006455	ligand binding site [chemical binding]; other site
298654006456	putative active site [active]
298654006457	NAD(P) binding site [chemical binding]; other site
298654006458	hypothetical protein; Provisional; Region: PRK06541
298654006459	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654006460	inhibitor-cofactor binding pocket; inhibition site
298654006461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654006462	catalytic residue [active]
298654006463	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654006464	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298654006465	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654006466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654006467	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298654006468	dimerization interface [polypeptide binding]; other site
298654006469	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
298654006470	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
298654006471	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
298654006472	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654006473	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654006474	YCII-related domain; Region: YCII; cl00999
298654006475	FMN binding site [chemical binding]; other site
298654006476	Nitroreductase family; Region: Nitroreductase; pfam00881
298654006477	dimer interface [polypeptide binding]; other site
298654006478	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
298654006479	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654006480	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654006481	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654006482	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654006483	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654006484	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654006485	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654006486	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654006487	Transcriptional regulator PadR-like family; Region: PadR; cl17335
298654006488	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654006489	active site
298654006490	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654006491	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
298654006492	intersubunit interface [polypeptide binding]; other site
298654006493	active site
298654006494	Zn2+ binding site [ion binding]; other site
298654006495	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006496	Cytochrome P450; Region: p450; cl12078
298654006497	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
298654006498	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
298654006499	malonyl-CoA binding site [chemical binding]; other site
298654006500	dimer interface [polypeptide binding]; other site
298654006501	active site
298654006502	product binding site; other site
298654006503	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654006504	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
298654006505	substrate binding pocket [chemical binding]; other site
298654006506	catalytic triad [active]
298654006507	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654006508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654006509	active site
298654006510	phosphorylation site [posttranslational modification]
298654006511	intermolecular recognition site; other site
298654006512	dimerization interface [polypeptide binding]; other site
298654006513	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654006514	DNA binding residues [nucleotide binding]
298654006515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654006516	Histidine kinase; Region: HisKA_3; pfam07730
298654006517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654006518	ATP binding site [chemical binding]; other site
298654006519	Mg2+ binding site [ion binding]; other site
298654006520	G-X-G motif; other site
298654006521	hypothetical protein; Provisional; Region: PRK06194
298654006522	classical (c) SDRs; Region: SDR_c; cd05233
298654006523	NAD(P) binding site [chemical binding]; other site
298654006524	active site
298654006525	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654006526	classical (c) SDRs; Region: SDR_c; cd05233
298654006527	NAD(P) binding site [chemical binding]; other site
298654006528	active site
298654006529	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654006530	S-adenosylmethionine binding site [chemical binding]; other site
298654006531	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
298654006532	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
298654006533	FOG: CBS domain [General function prediction only]; Region: COG0517
298654006534	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
298654006535	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
298654006536	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654006537	dimer interface [polypeptide binding]; other site
298654006538	active site
298654006539	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
298654006540	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
298654006541	cleavage site
298654006542	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654006543	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654006544	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654006545	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
298654006546	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
298654006547	NodB motif; other site
298654006548	active site
298654006549	catalytic site [active]
298654006550	metal binding site [ion binding]; metal-binding site
298654006551	enoyl-CoA hydratase; Provisional; Region: PRK06190
298654006552	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654006553	substrate binding site [chemical binding]; other site
298654006554	oxyanion hole (OAH) forming residues; other site
298654006555	trimer interface [polypeptide binding]; other site
298654006556	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006557	Cytochrome P450; Region: p450; cl12078
298654006558	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
298654006559	Predicted membrane protein [Function unknown]; Region: COG2323
298654006560	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
298654006561	putative deacylase active site [active]
298654006562	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654006563	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654006564	active site
298654006565	catalytic tetrad [active]
298654006566	Flavoprotein; Region: Flavoprotein; pfam02441
298654006567	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654006568	S-adenosylmethionine binding site [chemical binding]; other site
298654006569	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654006570	MarR family; Region: MarR_2; pfam12802
298654006571	MarR family; Region: MarR_2; cl17246
298654006572	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654006573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006574	putative substrate translocation pore; other site
298654006575	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
298654006576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654006577	motif II; other site
298654006578	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654006579	ligand binding site [chemical binding]; other site
298654006580	flexible hinge region; other site
298654006581	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654006582	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654006583	ATP binding site [chemical binding]; other site
298654006584	Mg2+ binding site [ion binding]; other site
298654006585	G-X-G motif; other site
298654006586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654006587	Response regulator receiver domain; Region: Response_reg; pfam00072
298654006588	active site
298654006589	phosphorylation site [posttranslational modification]
298654006590	intermolecular recognition site; other site
298654006591	dimerization interface [polypeptide binding]; other site
298654006592	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298654006593	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
298654006594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654006595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654006596	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
298654006597	dimerization interface [polypeptide binding]; other site
298654006598	DNA binding residues [nucleotide binding]
298654006599	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654006600	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654006601	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654006602	enoyl-CoA hydratase; Provisional; Region: PRK06210
298654006603	substrate binding site [chemical binding]; other site
298654006604	oxyanion hole (OAH) forming residues; other site
298654006605	trimer interface [polypeptide binding]; other site
298654006606	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654006607	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654006608	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654006609	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654006610	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654006611	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
298654006612	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654006613	acyl-activating enzyme (AAE) consensus motif; other site
298654006614	acyl-activating enzyme (AAE) consensus motif; other site
298654006615	putative AMP binding site [chemical binding]; other site
298654006616	putative active site [active]
298654006617	putative CoA binding site [chemical binding]; other site
298654006618	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
298654006619	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654006620	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
298654006621	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654006622	dimer interface [polypeptide binding]; other site
298654006623	active site
298654006624	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006625	Cytochrome P450; Region: p450; cl12078
298654006626	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654006627	classical (c) SDRs; Region: SDR_c; cd05233
298654006628	NAD(P) binding site [chemical binding]; other site
298654006629	active site
298654006630	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654006631	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654006632	acyl-activating enzyme (AAE) consensus motif; other site
298654006633	AMP binding site [chemical binding]; other site
298654006634	active site
298654006635	CoA binding site [chemical binding]; other site
298654006636	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
298654006637	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654006638	Cupin domain; Region: Cupin_2; cl17218
298654006639	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654006640	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654006641	active site
298654006642	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654006643	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654006644	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654006645	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654006646	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654006647	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654006648	active site
298654006649	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654006650	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654006651	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654006652	active site
298654006653	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
298654006654	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
298654006655	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654006656	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654006657	Ecdysteroid kinase; Region: EcKinase; cl17738
298654006658	Phosphotransferase enzyme family; Region: APH; pfam01636
298654006659	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654006660	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654006661	substrate binding site [chemical binding]; other site
298654006662	oxyanion hole (OAH) forming residues; other site
298654006663	trimer interface [polypeptide binding]; other site
298654006664	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654006665	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
298654006666	short chain dehydrogenase; Provisional; Region: PRK06940
298654006667	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654006668	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
298654006669	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654006670	NAD binding site [chemical binding]; other site
298654006671	catalytic Zn binding site [ion binding]; other site
298654006672	substrate binding site [chemical binding]; other site
298654006673	structural Zn binding site [ion binding]; other site
298654006674	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654006675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654006676	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654006677	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654006678	NAD binding site [chemical binding]; other site
298654006679	catalytic residues [active]
298654006680	classical (c) SDRs; Region: SDR_c; cd05233
298654006681	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
298654006682	NAD(P) binding site [chemical binding]; other site
298654006683	active site
298654006684	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654006685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654006686	NAD(P) binding site [chemical binding]; other site
298654006687	active site
298654006688	acyl-CoA synthetase; Validated; Region: PRK06188
298654006689	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654006690	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654006691	acyl-activating enzyme (AAE) consensus motif; other site
298654006692	acyl-activating enzyme (AAE) consensus motif; other site
298654006693	putative AMP binding site [chemical binding]; other site
298654006694	putative active site [active]
298654006695	putative CoA binding site [chemical binding]; other site
298654006696	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654006697	putative active site [active]
298654006698	putative substrate binding site [chemical binding]; other site
298654006699	ATP binding site [chemical binding]; other site
298654006700	Phosphotransferase enzyme family; Region: APH; pfam01636
298654006701	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006702	Cytochrome P450; Region: p450; cl12078
298654006703	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654006704	hydrophobic ligand binding site; other site
298654006705	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
298654006706	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654006707	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654006708	active site
298654006709	ATP binding site [chemical binding]; other site
298654006710	substrate binding site [chemical binding]; other site
298654006711	activation loop (A-loop); other site
298654006712	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
298654006713	Ferritin-like domain; Region: Ferritin; pfam00210
298654006714	dinuclear metal binding motif [ion binding]; other site
298654006715	carbon starvation protein A; Provisional; Region: PRK15015
298654006716	Carbon starvation protein CstA; Region: CstA; pfam02554
298654006717	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
298654006718	Beta-lactamase; Region: Beta-lactamase; pfam00144
298654006719	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298654006720	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654006721	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654006722	ligand binding site [chemical binding]; other site
298654006723	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654006724	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298654006725	Walker A/P-loop; other site
298654006726	ATP binding site [chemical binding]; other site
298654006727	Q-loop/lid; other site
298654006728	ABC transporter signature motif; other site
298654006729	Walker B; other site
298654006730	D-loop; other site
298654006731	H-loop/switch region; other site
298654006732	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654006733	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298654006734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654006735	Histidine kinase; Region: HisKA_3; pfam07730
298654006736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654006737	ATP binding site [chemical binding]; other site
298654006738	Mg2+ binding site [ion binding]; other site
298654006739	G-X-G motif; other site
298654006740	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654006741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654006742	active site
298654006743	phosphorylation site [posttranslational modification]
298654006744	intermolecular recognition site; other site
298654006745	dimerization interface [polypeptide binding]; other site
298654006746	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654006747	DNA binding residues [nucleotide binding]
298654006748	dimerization interface [polypeptide binding]; other site
298654006749	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654006750	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654006751	putative ligand binding site [chemical binding]; other site
298654006752	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
298654006753	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654006754	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
298654006755	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
298654006756	tetramer interface [polypeptide binding]; other site
298654006757	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
298654006758	active site
298654006759	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
298654006760	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
298654006761	active site
298654006762	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654006763	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654006764	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654006765	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654006766	MarR family; Region: MarR; pfam01047
298654006767	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654006768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654006769	substrate binding site [chemical binding]; other site
298654006770	oxyanion hole (OAH) forming residues; other site
298654006771	trimer interface [polypeptide binding]; other site
298654006772	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
298654006773	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654006774	acyl-activating enzyme (AAE) consensus motif; other site
298654006775	AMP binding site [chemical binding]; other site
298654006776	active site
298654006777	CoA binding site [chemical binding]; other site
298654006778	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
298654006779	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
298654006780	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654006781	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654006782	DNA binding residues [nucleotide binding]
298654006783	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
298654006784	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298654006785	NAD binding site [chemical binding]; other site
298654006786	substrate binding site [chemical binding]; other site
298654006787	putative active site [active]
298654006788	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654006789	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654006790	active site
298654006791	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654006792	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654006793	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654006794	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654006795	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654006796	putative ligand binding site [chemical binding]; other site
298654006797	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654006798	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654006799	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654006800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006801	putative substrate translocation pore; other site
298654006802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006803	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
298654006804	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
298654006805	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
298654006806	active site
298654006807	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
298654006808	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654006809	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654006810	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654006811	nucleotide binding site [chemical binding]; other site
298654006812	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
298654006813	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654006814	active site
298654006815	metal binding site [ion binding]; metal-binding site
298654006816	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
298654006817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654006818	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654006819	salt bridge; other site
298654006820	non-specific DNA binding site [nucleotide binding]; other site
298654006821	sequence-specific DNA binding site [nucleotide binding]; other site
298654006822	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
298654006823	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654006824	catalytic triad [active]
298654006825	CCC1-related family of proteins; Region: CCC1_like; cl00278
298654006826	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
298654006827	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
298654006828	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
298654006829	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
298654006830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654006831	NAD(P) binding site [chemical binding]; other site
298654006832	active site
298654006833	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
298654006834	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654006835	nudix motif; other site
298654006836	FMN binding site [chemical binding]; other site
298654006837	Nitroreductase family; Region: Nitroreductase; pfam00881
298654006838	dimer interface [polypeptide binding]; other site
298654006839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654006840	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654006841	NAD(P) binding site [chemical binding]; other site
298654006842	active site
298654006843	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654006844	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654006845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654006846	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298654006847	NAD(P) binding site [chemical binding]; other site
298654006848	active site
298654006849	Predicted transcriptional regulator [Transcription]; Region: COG1959
298654006850	Transcriptional regulator; Region: Rrf2; pfam02082
298654006851	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
298654006852	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654006853	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654006854	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
298654006855	Walker A/P-loop; other site
298654006856	ATP binding site [chemical binding]; other site
298654006857	Q-loop/lid; other site
298654006858	ABC transporter signature motif; other site
298654006859	Walker B; other site
298654006860	D-loop; other site
298654006861	H-loop/switch region; other site
298654006862	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
298654006863	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654006864	Domain of unknown function DUF302; Region: DUF302; cl01364
298654006865	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
298654006866	ATP-NAD kinase; Region: NAD_kinase; pfam01513
298654006867	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
298654006868	active site
298654006869	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654006870	Methyltransferase domain; Region: Methyltransf_31; pfam13847
298654006871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654006872	S-adenosylmethionine binding site [chemical binding]; other site
298654006873	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654006874	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654006875	active site
298654006876	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654006877	active site
298654006878	metal binding site [ion binding]; metal-binding site
298654006879	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654006880	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654006881	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006882	Cytochrome P450; Region: p450; cl12078
298654006883	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006884	Cytochrome P450; Region: p450; cl12078
298654006885	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
298654006886	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654006887	putative substrate translocation pore; other site
298654006888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654006889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654006890	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
298654006891	dimerization interface [polypeptide binding]; other site
298654006892	substrate binding pocket [chemical binding]; other site
298654006893	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
298654006894	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
298654006895	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654006896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654006897	dimer interface [polypeptide binding]; other site
298654006898	conserved gate region; other site
298654006899	putative PBP binding loops; other site
298654006900	ABC-ATPase subunit interface; other site
298654006901	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654006902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654006903	dimer interface [polypeptide binding]; other site
298654006904	conserved gate region; other site
298654006905	putative PBP binding loops; other site
298654006906	ABC-ATPase subunit interface; other site
298654006907	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
298654006908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654006909	Walker A/P-loop; other site
298654006910	ATP binding site [chemical binding]; other site
298654006911	Q-loop/lid; other site
298654006912	ABC transporter signature motif; other site
298654006913	Walker B; other site
298654006914	D-loop; other site
298654006915	H-loop/switch region; other site
298654006916	TOBE domain; Region: TOBE_2; pfam08402
298654006917	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006918	Cytochrome P450; Region: p450; cl12078
298654006919	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654006920	Cytochrome P450; Region: p450; cl12078
298654006921	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654006922	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
298654006923	acyl-activating enzyme (AAE) consensus motif; other site
298654006924	active site
298654006925	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
298654006926	dinuclear metal binding motif [ion binding]; other site
298654006927	Ferritin-like domain; Region: Ferritin; pfam00210
298654006928	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654006929	CoenzymeA binding site [chemical binding]; other site
298654006930	subunit interaction site [polypeptide binding]; other site
298654006931	PHB binding site; other site
298654006932	Phosphopantetheine attachment site; Region: PP-binding; cl09936
298654006933	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
298654006934	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654006935	S-adenosylmethionine binding site [chemical binding]; other site
298654006936	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
298654006937	dinuclear metal binding motif [ion binding]; other site
298654006938	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654006939	classical (c) SDRs; Region: SDR_c; cd05233
298654006940	NAD(P) binding site [chemical binding]; other site
298654006941	active site
298654006942	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
298654006943	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
298654006944	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654006945	catalytic residue [active]
298654006946	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
298654006947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654006948	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654006949	acyl-activating enzyme (AAE) consensus motif; other site
298654006950	acyl-activating enzyme (AAE) consensus motif; other site
298654006951	AMP binding site [chemical binding]; other site
298654006952	active site
298654006953	CoA binding site [chemical binding]; other site
298654006954	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
298654006955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654006956	NAD(P) binding site [chemical binding]; other site
298654006957	active site
298654006958	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654006959	CoenzymeA binding site [chemical binding]; other site
298654006960	subunit interaction site [polypeptide binding]; other site
298654006961	PHB binding site; other site
298654006962	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654006963	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654006964	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
298654006965	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654006966	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654006967	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654006968	hydrophobic ligand binding site; other site
298654006969	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654006970	Transcriptional regulator PadR-like family; Region: PadR; cl17335
298654006971	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
298654006972	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654006973	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
298654006974	DNA binding residues [nucleotide binding]
298654006975	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
298654006976	iron-sulfur cluster [ion binding]; other site
298654006977	[2Fe-2S] cluster binding site [ion binding]; other site
298654006978	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
298654006979	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
298654006980	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654006981	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654006982	active site
298654006983	metal binding site [ion binding]; metal-binding site
298654006984	Mechanosensitive ion channel; Region: MS_channel; pfam00924
298654006985	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
298654006986	Predicted membrane protein [Function unknown]; Region: COG2261
298654006987	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
298654006988	Fatty acid desaturase; Region: FA_desaturase; pfam00487
298654006989	Di-iron ligands [ion binding]; other site
298654006990	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
298654006991	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654006992	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
298654006993	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654006994	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
298654006995	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654006996	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654006997	DNA binding residues [nucleotide binding]
298654006998	dimerization interface [polypeptide binding]; other site
298654006999	tellurite resistance protein terB; Region: terB; cd07176
298654007000	putative metal binding site [ion binding]; other site
298654007001	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
298654007002	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
298654007003	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654007004	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
298654007005	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654007006	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654007007	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654007008	putative ligand binding site [chemical binding]; other site
298654007009	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654007010	putative AMP binding site [chemical binding]; other site
298654007011	putative active site [active]
298654007012	acyl-activating enzyme (AAE) consensus motif; other site
298654007013	putative CoA binding site [chemical binding]; other site
298654007014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007016	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654007017	Cytochrome P450; Region: p450; cl12078
298654007018	Clp amino terminal domain; Region: Clp_N; pfam02861
298654007019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007020	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654007021	NAD(P) binding site [chemical binding]; other site
298654007022	active site
298654007023	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654007024	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007025	substrate binding site [chemical binding]; other site
298654007026	oxyanion hole (OAH) forming residues; other site
298654007027	trimer interface [polypeptide binding]; other site
298654007028	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
298654007029	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
298654007030	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
298654007031	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654007032	enoyl-CoA hydratase; Provisional; Region: PRK06144
298654007033	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007034	substrate binding site [chemical binding]; other site
298654007035	oxyanion hole (OAH) forming residues; other site
298654007036	trimer interface [polypeptide binding]; other site
298654007037	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654007038	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654007039	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007040	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
298654007041	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654007042	putative active site [active]
298654007043	heme pocket [chemical binding]; other site
298654007044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654007045	dimer interface [polypeptide binding]; other site
298654007046	phosphorylation site [posttranslational modification]
298654007047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654007048	ATP binding site [chemical binding]; other site
298654007049	Mg2+ binding site [ion binding]; other site
298654007050	G-X-G motif; other site
298654007051	Response regulator receiver domain; Region: Response_reg; pfam00072
298654007052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654007053	active site
298654007054	phosphorylation site [posttranslational modification]
298654007055	intermolecular recognition site; other site
298654007056	dimerization interface [polypeptide binding]; other site
298654007057	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
298654007058	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
298654007059	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
298654007060	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
298654007061	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654007062	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007063	Kelch motif; Region: Kelch_6; pfam13964
298654007064	Protein of unknown function (DUF732); Region: DUF732; pfam05305
298654007065	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
298654007066	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007067	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
298654007068	putative active site [active]
298654007069	putative catalytic site [active]
298654007070	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007071	active site 2 [active]
298654007072	active site 1 [active]
298654007073	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654007074	MarR family; Region: MarR_2; pfam12802
298654007075	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
298654007076	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654007077	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654007078	active site
298654007079	ATP binding site [chemical binding]; other site
298654007080	substrate binding site [chemical binding]; other site
298654007081	activation loop (A-loop); other site
298654007082	Predicted transcriptional regulator [Transcription]; Region: COG2378
298654007083	HTH domain; Region: HTH_11; pfam08279
298654007084	WYL domain; Region: WYL; pfam13280
298654007085	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007086	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007087	Pirin-related protein [General function prediction only]; Region: COG1741
298654007088	Pirin; Region: Pirin; pfam02678
298654007089	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
298654007090	Acylphosphatase; Region: Acylphosphatase; pfam00708
298654007091	HypF finger; Region: zf-HYPF; pfam07503
298654007092	HypF finger; Region: zf-HYPF; pfam07503
298654007093	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
298654007094	TIR domain; Region: TIR_2; pfam13676
298654007095	AAA ATPase domain; Region: AAA_16; pfam13191
298654007096	NACHT domain; Region: NACHT; pfam05729
298654007097	HEAT repeats; Region: HEAT_2; pfam13646
298654007098	HEAT repeats; Region: HEAT_2; pfam13646
298654007099	HEAT repeats; Region: HEAT_2; pfam13646
298654007100	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
298654007101	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
298654007102	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
298654007103	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
298654007104	dimerization interface [polypeptide binding]; other site
298654007105	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
298654007106	ATP binding site [chemical binding]; other site
298654007107	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
298654007108	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
298654007109	HupF/HypC family; Region: HupF_HypC; pfam01455
298654007110	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
298654007111	nickel binding site [ion binding]; other site
298654007112	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
298654007113	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
298654007114	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
298654007115	HupF/HypC family; Region: HupF_HypC; cl00394
298654007116	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
298654007117	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
298654007118	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
298654007119	Soluble P-type ATPase [General function prediction only]; Region: COG4087
298654007120	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
298654007121	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
298654007122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654007123	Coenzyme A binding pocket [chemical binding]; other site
298654007124	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
298654007125	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
298654007126	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
298654007127	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
298654007128	TPP-binding site [chemical binding]; other site
298654007129	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
298654007130	TPP-binding site [chemical binding]; other site
298654007131	tetramer interface [polypeptide binding]; other site
298654007132	phosphorylation loop region [posttranslational modification]
298654007133	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
298654007134	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
298654007135	alpha subunit interface [polypeptide binding]; other site
298654007136	TPP binding site [chemical binding]; other site
298654007137	heterodimer interface [polypeptide binding]; other site
298654007138	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654007139	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298654007140	E3 interaction surface; other site
298654007141	lipoyl attachment site [posttranslational modification]; other site
298654007142	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
298654007143	e3 binding domain; Region: E3_binding; pfam02817
298654007144	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298654007145	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007146	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654007147	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
298654007148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654007149	S-adenosylmethionine binding site [chemical binding]; other site
298654007150	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654007151	FAD binding domain; Region: FAD_binding_4; pfam01565
298654007152	Tetratricopeptide repeat; Region: TPR_10; cl17452
298654007153	Transposase, Mutator family; Region: Transposase_mut; pfam00872
298654007154	MULE transposase domain; Region: MULE; pfam10551
298654007155	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
298654007156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007157	NAD(P) binding site [chemical binding]; other site
298654007158	active site
298654007159	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654007160	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316
298654007161	classical (c) SDRs; Region: SDR_c; cd05233
298654007162	NAD(P) binding site [chemical binding]; other site
298654007163	active site
298654007164	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007165	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007166	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007167	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654007168	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654007169	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
298654007170	putative hydrophobic ligand binding site [chemical binding]; other site
298654007171	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
298654007172	dimer interface [polypeptide binding]; other site
298654007173	substrate binding site [chemical binding]; other site
298654007174	metal binding site [ion binding]; metal-binding site
298654007175	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
298654007176	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654007177	catalytic loop [active]
298654007178	iron binding site [ion binding]; other site
298654007179	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
298654007180	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
298654007181	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
298654007182	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
298654007183	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
298654007184	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298654007185	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654007186	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654007187	classical (c) SDRs; Region: SDR_c; cd05233
298654007188	NAD(P) binding site [chemical binding]; other site
298654007189	active site
298654007190	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654007191	active site
298654007192	metal binding site [ion binding]; metal-binding site
298654007193	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654007194	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007195	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654007196	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654007197	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654007198	NAD(P) binding site [chemical binding]; other site
298654007199	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654007200	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654007201	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654007202	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654007203	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007204	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007205	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654007206	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007207	NAD(P) binding site [chemical binding]; other site
298654007208	active site
298654007209	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
298654007210	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654007211	DNA binding residues [nucleotide binding]
298654007212	B12 binding domain; Region: B12-binding_2; pfam02607
298654007213	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
298654007214	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
298654007215	substrate binding pocket [chemical binding]; other site
298654007216	chain length determination region; other site
298654007217	substrate-Mg2+ binding site; other site
298654007218	catalytic residues [active]
298654007219	aspartate-rich region 1; other site
298654007220	active site lid residues [active]
298654007221	aspartate-rich region 2; other site
298654007222	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654007223	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654007224	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007225	active site 2 [active]
298654007226	active site 1 [active]
298654007227	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007228	active site 2 [active]
298654007229	active site 1 [active]
298654007230	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007231	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007232	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007233	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007234	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
298654007235	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298654007236	active site
298654007237	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654007238	catalytic triad [active]
298654007239	dimer interface [polypeptide binding]; other site
298654007240	putative acyltransferase; Provisional; Region: PRK05790
298654007241	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654007242	dimer interface [polypeptide binding]; other site
298654007243	active site
298654007244	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007245	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654007246	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654007247	active site
298654007248	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007249	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007250	active site
298654007251	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654007252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654007253	metal binding site [ion binding]; metal-binding site
298654007254	active site
298654007255	I-site; other site
298654007256	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007257	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007258	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654007259	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
298654007260	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654007261	NAD binding site [chemical binding]; other site
298654007262	catalytic Zn binding site [ion binding]; other site
298654007263	substrate binding site [chemical binding]; other site
298654007264	structural Zn binding site [ion binding]; other site
298654007265	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007266	thiolase; Provisional; Region: PRK06158
298654007267	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654007268	active site
298654007269	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
298654007270	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007271	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654007272	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654007273	classical (c) SDRs; Region: SDR_c; cd05233
298654007274	NAD(P) binding site [chemical binding]; other site
298654007275	active site
298654007276	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654007277	classical (c) SDRs; Region: SDR_c; cd05233
298654007278	NAD(P) binding site [chemical binding]; other site
298654007279	active site
298654007280	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654007281	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007282	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007283	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007286	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
298654007287	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654007288	dimer interface [polypeptide binding]; other site
298654007289	active site
298654007290	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007291	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007292	active site
298654007293	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
298654007294	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007295	NAD(P) binding site [chemical binding]; other site
298654007296	active site
298654007297	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654007298	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007299	substrate binding site [chemical binding]; other site
298654007300	oxyanion hole (OAH) forming residues; other site
298654007301	trimer interface [polypeptide binding]; other site
298654007302	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654007303	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654007305	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654007306	putative substrate translocation pore; other site
298654007307	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654007308	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654007309	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654007310	putative ligand binding site [chemical binding]; other site
298654007311	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654007312	classical (c) SDRs; Region: SDR_c; cd05233
298654007313	NAD(P) binding site [chemical binding]; other site
298654007314	active site
298654007315	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654007316	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007317	substrate binding site [chemical binding]; other site
298654007318	oxyanion hole (OAH) forming residues; other site
298654007319	trimer interface [polypeptide binding]; other site
298654007320	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654007321	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007322	NAD(P) binding site [chemical binding]; other site
298654007323	active site
298654007324	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654007325	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007326	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007327	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007328	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654007329	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654007330	lipid-transfer protein; Provisional; Region: PRK07855
298654007331	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654007332	active site
298654007333	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007334	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007335	active site
298654007336	classical (c) SDRs; Region: SDR_c; cd05233
298654007337	NAD(P) binding site [chemical binding]; other site
298654007338	active site
298654007339	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654007340	classical (c) SDRs; Region: SDR_c; cd05233
298654007341	NAD(P) binding site [chemical binding]; other site
298654007342	active site
298654007343	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654007344	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654007345	classical (c) SDRs; Region: SDR_c; cd05233
298654007346	NAD(P) binding site [chemical binding]; other site
298654007347	active site
298654007348	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007349	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007350	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007351	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654007352	active site
298654007353	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007354	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007355	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007356	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654007357	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654007358	putative active site [active]
298654007359	putative substrate binding site [chemical binding]; other site
298654007360	ATP binding site [chemical binding]; other site
298654007361	Phosphotransferase enzyme family; Region: APH; pfam01636
298654007362	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
298654007363	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007364	NAD(P) binding site [chemical binding]; other site
298654007365	active site
298654007366	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654007367	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654007368	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654007369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654007370	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654007371	MarR family; Region: MarR_2; pfam12802
298654007372	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
298654007373	active site
298654007374	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654007375	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298654007376	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007377	NAD(P) binding site [chemical binding]; other site
298654007378	active site
298654007379	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
298654007380	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298654007381	Active Sites [active]
298654007382	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
298654007383	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
298654007384	CysD dimerization site [polypeptide binding]; other site
298654007385	G1 box; other site
298654007386	putative GEF interaction site [polypeptide binding]; other site
298654007387	GTP/Mg2+ binding site [chemical binding]; other site
298654007388	Switch I region; other site
298654007389	G2 box; other site
298654007390	G3 box; other site
298654007391	Switch II region; other site
298654007392	G4 box; other site
298654007393	G5 box; other site
298654007394	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
298654007395	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
298654007396	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
298654007397	ligand-binding site [chemical binding]; other site
298654007398	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
298654007399	Cupin domain; Region: Cupin_2; cl17218
298654007400	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654007401	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654007402	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
298654007403	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654007404	active site
298654007405	metal binding site [ion binding]; metal-binding site
298654007406	DNA binding site [nucleotide binding]
298654007407	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654007408	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654007409	NAD(P) binding site [chemical binding]; other site
298654007410	catalytic residues [active]
298654007411	enoyl-CoA hydratase; Provisional; Region: PRK06495
298654007412	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007413	substrate binding site [chemical binding]; other site
298654007414	oxyanion hole (OAH) forming residues; other site
298654007415	trimer interface [polypeptide binding]; other site
298654007416	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654007417	AMP-binding enzyme; Region: AMP-binding; pfam00501
298654007418	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654007419	acyl-activating enzyme (AAE) consensus motif; other site
298654007420	AMP binding site [chemical binding]; other site
298654007421	active site
298654007422	CoA binding site [chemical binding]; other site
298654007423	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007424	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654007425	active site
298654007426	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007427	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654007428	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654007429	active site
298654007430	acyl-CoA synthetase; Validated; Region: PRK07798
298654007431	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
298654007432	acyl-activating enzyme (AAE) consensus motif; other site
298654007433	AMP binding site [chemical binding]; other site
298654007434	active site
298654007435	CoA binding site [chemical binding]; other site
298654007436	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654007437	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007438	substrate binding site [chemical binding]; other site
298654007439	oxyanion hole (OAH) forming residues; other site
298654007440	trimer interface [polypeptide binding]; other site
298654007441	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654007442	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007443	active site
298654007444	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654007445	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654007446	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007447	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007448	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298654007449	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654007450	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
298654007451	NAD(P) binding site [chemical binding]; other site
298654007452	catalytic residues [active]
298654007453	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654007454	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007455	substrate binding site [chemical binding]; other site
298654007456	oxyanion hole (OAH) forming residues; other site
298654007457	trimer interface [polypeptide binding]; other site
298654007458	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007459	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007460	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007461	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007462	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007463	active site
298654007464	enoyl-CoA hydratase; Provisional; Region: PRK06144
298654007465	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007466	substrate binding site [chemical binding]; other site
298654007467	oxyanion hole (OAH) forming residues; other site
298654007468	trimer interface [polypeptide binding]; other site
298654007469	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
298654007470	active site
298654007471	metal binding site [ion binding]; metal-binding site
298654007472	homotetramer interface [polypeptide binding]; other site
298654007473	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654007474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007475	NAD(P) binding site [chemical binding]; other site
298654007476	active site
298654007477	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007478	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007479	active site 2 [active]
298654007480	active site 1 [active]
298654007481	short chain dehydrogenase; Provisional; Region: PRK07791
298654007482	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
298654007483	homodimer interface [polypeptide binding]; other site
298654007484	NAD binding site [chemical binding]; other site
298654007485	active site
298654007486	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007487	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654007488	classical (c) SDRs; Region: SDR_c; cd05233
298654007489	NAD(P) binding site [chemical binding]; other site
298654007490	active site
298654007491	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654007492	Cytochrome P450; Region: p450; cl12078
298654007493	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
298654007494	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007495	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654007496	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654007497	NAD binding site [chemical binding]; other site
298654007498	catalytic residues [active]
298654007499	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654007500	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654007501	putative ligand binding site [chemical binding]; other site
298654007502	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007503	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654007504	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654007505	active site
298654007506	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
298654007507	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007508	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654007509	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654007510	[2Fe-2S] cluster binding site [ion binding]; other site
298654007511	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654007512	alpha subunit interface [polypeptide binding]; other site
298654007513	active site
298654007514	substrate binding site [chemical binding]; other site
298654007515	Fe binding site [ion binding]; other site
298654007516	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007517	active site 1 [active]
298654007518	active site 2 [active]
298654007519	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654007520	active site 2 [active]
298654007521	active site 1 [active]
298654007522	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
298654007523	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
298654007524	Histidine kinase; Region: HisKA_3; pfam07730
298654007525	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654007526	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654007527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654007528	active site
298654007529	phosphorylation site [posttranslational modification]
298654007530	intermolecular recognition site; other site
298654007531	dimerization interface [polypeptide binding]; other site
298654007532	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654007533	dimerization interface [polypeptide binding]; other site
298654007534	DNA binding residues [nucleotide binding]
298654007535	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654007536	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654007537	metal binding site [ion binding]; metal-binding site
298654007538	active site
298654007539	I-site; other site
298654007540	Transcriptional activator [Transcription]; Region: ChrR; COG3806
298654007541	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654007542	Cytochrome P450; Region: p450; cl12078
298654007543	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
298654007544	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654007545	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
298654007546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007547	NAD(P) binding site [chemical binding]; other site
298654007548	active site
298654007549	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007550	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654007551	substrate binding site [chemical binding]; other site
298654007552	oxyanion hole (OAH) forming residues; other site
298654007553	trimer interface [polypeptide binding]; other site
298654007554	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
298654007555	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
298654007556	substrate binding site [chemical binding]; other site
298654007557	oxyanion hole (OAH) forming residues; other site
298654007558	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654007559	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
298654007560	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654007561	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654007562	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
298654007563	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654007564	carboxyltransferase (CT) interaction site; other site
298654007565	biotinylation site [posttranslational modification]; other site
298654007566	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
298654007567	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007568	TIGR03084 family protein; Region: TIGR03084
298654007569	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654007570	enoyl-CoA hydratase; Provisional; Region: PRK05995
298654007571	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007572	substrate binding site [chemical binding]; other site
298654007573	oxyanion hole (OAH) forming residues; other site
298654007574	trimer interface [polypeptide binding]; other site
298654007575	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654007576	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654007577	active site
298654007578	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654007579	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007580	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007581	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007582	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007583	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007584	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654007585	SnoaL-like domain; Region: SnoaL_3; pfam13474
298654007586	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654007587	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654007588	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654007589	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654007590	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654007591	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654007592	substrate binding site [chemical binding]; other site
298654007593	oxyanion hole (OAH) forming residues; other site
298654007594	trimer interface [polypeptide binding]; other site
298654007595	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007596	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007597	active site
298654007598	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654007599	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007600	active site
298654007601	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007602	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007603	active site
298654007604	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654007605	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654007606	DNA-binding site [nucleotide binding]; DNA binding site
298654007607	FCD domain; Region: FCD; pfam07729
298654007608	Cupin domain; Region: Cupin_2; pfam07883
298654007609	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007610	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
298654007611	ligand binding site [chemical binding]; other site
298654007612	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
298654007613	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298654007614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654007615	Walker A/P-loop; other site
298654007616	ATP binding site [chemical binding]; other site
298654007617	Q-loop/lid; other site
298654007618	ABC transporter signature motif; other site
298654007619	Walker B; other site
298654007620	D-loop; other site
298654007621	H-loop/switch region; other site
298654007622	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298654007623	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654007624	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654007625	TM-ABC transporter signature motif; other site
298654007626	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
298654007627	active site
298654007628	oxalacetate binding site [chemical binding]; other site
298654007629	citrylCoA binding site [chemical binding]; other site
298654007630	coenzyme A binding site [chemical binding]; other site
298654007631	catalytic triad [active]
298654007632	Predicted esterase [General function prediction only]; Region: COG0627
298654007633	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
298654007634	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654007635	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654007636	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654007637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654007638	active site
298654007639	phosphorylation site [posttranslational modification]
298654007640	intermolecular recognition site; other site
298654007641	dimerization interface [polypeptide binding]; other site
298654007642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654007643	DNA binding site [nucleotide binding]
298654007644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654007645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654007646	dimer interface [polypeptide binding]; other site
298654007647	phosphorylation site [posttranslational modification]
298654007648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654007649	ATP binding site [chemical binding]; other site
298654007650	Mg2+ binding site [ion binding]; other site
298654007651	G-X-G motif; other site
298654007652	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654007653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007654	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
298654007655	NAD(P) binding site [chemical binding]; other site
298654007656	active site
298654007657	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654007658	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
298654007659	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654007660	NAD binding site [chemical binding]; other site
298654007661	catalytic Zn binding site [ion binding]; other site
298654007662	substrate binding site [chemical binding]; other site
298654007663	structural Zn binding site [ion binding]; other site
298654007664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007665	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654007666	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654007667	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654007668	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654007669	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654007670	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654007671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007672	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
298654007673	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654007674	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
298654007675	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654007676	Cytochrome P450; Region: p450; cl12078
298654007677	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
298654007678	active site 2 [active]
298654007679	active site 1 [active]
298654007680	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654007681	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298654007682	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654007683	P-loop; other site
298654007684	Magnesium ion binding site [ion binding]; other site
298654007685	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654007686	Magnesium ion binding site [ion binding]; other site
298654007687	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
298654007688	active site
298654007689	Peptidase family M50; Region: Peptidase_M50; pfam02163
298654007690	putative substrate binding region [chemical binding]; other site
298654007691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654007692	Walker A motif; other site
298654007693	ATP binding site [chemical binding]; other site
298654007694	Walker B motif; other site
298654007695	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654007696	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654007697	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654007698	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654007699	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654007700	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
298654007701	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
298654007702	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
298654007703	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298654007704	RNA binding surface [nucleotide binding]; other site
298654007705	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
298654007706	active site
298654007707	prephenate dehydrogenase; Validated; Region: PRK06545
298654007708	prephenate dehydrogenase; Validated; Region: PRK08507
298654007709	cytidylate kinase; Provisional; Region: cmk; PRK00023
298654007710	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
298654007711	active site
298654007712	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
298654007713	CMP-binding site; other site
298654007714	The sites determining sugar specificity; other site
298654007715	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298654007716	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298654007717	putative acyl-acceptor binding pocket; other site
298654007718	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
298654007719	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
298654007720	G1 box; other site
298654007721	GTP/Mg2+ binding site [chemical binding]; other site
298654007722	Switch I region; other site
298654007723	G2 box; other site
298654007724	Switch II region; other site
298654007725	G3 box; other site
298654007726	G4 box; other site
298654007727	G5 box; other site
298654007728	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
298654007729	G1 box; other site
298654007730	GTP/Mg2+ binding site [chemical binding]; other site
298654007731	Switch I region; other site
298654007732	G2 box; other site
298654007733	G3 box; other site
298654007734	Switch II region; other site
298654007735	G4 box; other site
298654007736	G5 box; other site
298654007737	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
298654007738	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
298654007739	active site
298654007740	putative catalytic site [active]
298654007741	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298654007742	NlpC/P60 family; Region: NLPC_P60; pfam00877
298654007743	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
298654007744	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
298654007745	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
298654007746	active site
298654007747	Substrate binding site; other site
298654007748	Mg++ binding site; other site
298654007749	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
298654007750	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
298654007751	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
298654007752	active site
298654007753	substrate binding site [chemical binding]; other site
298654007754	metal binding site [ion binding]; metal-binding site
298654007755	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
298654007756	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
298654007757	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
298654007758	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
298654007759	lipoyl attachment site [posttranslational modification]; other site
298654007760	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
298654007761	Double zinc ribbon; Region: DZR; pfam12773
298654007762	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654007763	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654007764	phosphopeptide binding site; other site
298654007765	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
298654007766	DNA binding residues [nucleotide binding]
298654007767	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654007768	Bifunctional nuclease; Region: DNase-RNase; pfam02577
298654007769	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
298654007770	DNA binding residues [nucleotide binding]
298654007771	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
298654007772	putative dimer interface [polypeptide binding]; other site
298654007773	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654007774	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
298654007775	Walker A/P-loop; other site
298654007776	ATP binding site [chemical binding]; other site
298654007777	Q-loop/lid; other site
298654007778	ABC transporter signature motif; other site
298654007779	Walker B; other site
298654007780	D-loop; other site
298654007781	H-loop/switch region; other site
298654007782	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654007783	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654007784	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654007785	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
298654007786	active site
298654007787	homotetramer interface [polypeptide binding]; other site
298654007788	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654007789	catalytic core [active]
298654007790	Transcription factor WhiB; Region: Whib; pfam02467
298654007791	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
298654007792	Acyltransferase family; Region: Acyl_transf_3; pfam01757
298654007793	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
298654007794	Acyltransferase family; Region: Acyl_transf_3; pfam01757
298654007795	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654007796	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654007797	Histidine kinase; Region: HisKA_3; pfam07730
298654007798	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654007799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654007800	active site
298654007801	phosphorylation site [posttranslational modification]
298654007802	intermolecular recognition site; other site
298654007803	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654007804	DNA binding residues [nucleotide binding]
298654007805	dimerization interface [polypeptide binding]; other site
298654007806	Rhomboid family; Region: Rhomboid; pfam01694
298654007807	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
298654007808	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654007809	inhibitor-cofactor binding pocket; inhibition site
298654007810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654007811	catalytic residue [active]
298654007812	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654007813	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654007814	metal binding site [ion binding]; metal-binding site
298654007815	active site
298654007816	I-site; other site
298654007817	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
298654007818	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
298654007819	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
298654007820	NAD(P) binding pocket [chemical binding]; other site
298654007821	Protein of unknown function (DUF419); Region: DUF419; cl15265
298654007822	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
298654007823	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
298654007824	ligand binding site [chemical binding]; other site
298654007825	active site
298654007826	UGI interface [polypeptide binding]; other site
298654007827	catalytic site [active]
298654007828	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654007829	salt bridge; other site
298654007830	non-specific DNA binding site [nucleotide binding]; other site
298654007831	sequence-specific DNA binding site [nucleotide binding]; other site
298654007832	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654007833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654007834	putative substrate translocation pore; other site
298654007835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654007836	Part of AAA domain; Region: AAA_19; pfam13245
298654007837	LabA_like proteins; Region: LabA_like; cd06167
298654007838	putative metal binding site [ion binding]; other site
298654007839	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
298654007840	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
298654007841	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
298654007842	Na binding site [ion binding]; other site
298654007843	putative substrate binding site [chemical binding]; other site
298654007844	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654007845	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654007846	DNA-binding site [nucleotide binding]; DNA binding site
298654007847	FCD domain; Region: FCD; pfam07729
298654007848	Protein kinase domain; Region: Pkinase; pfam00069
298654007849	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654007850	active site
298654007851	ATP binding site [chemical binding]; other site
298654007852	substrate binding site [chemical binding]; other site
298654007853	activation loop (A-loop); other site
298654007854	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
298654007855	active site
298654007856	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298654007857	FtsX-like permease family; Region: FtsX; pfam02687
298654007858	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654007859	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654007860	Walker A/P-loop; other site
298654007861	ATP binding site [chemical binding]; other site
298654007862	Q-loop/lid; other site
298654007863	ABC transporter signature motif; other site
298654007864	Walker B; other site
298654007865	D-loop; other site
298654007866	H-loop/switch region; other site
298654007867	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
298654007868	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
298654007869	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
298654007870	Imelysin; Region: Peptidase_M75; pfam09375
298654007871	Iron permease FTR1 family; Region: FTR1; pfam03239
298654007872	Penicillinase repressor; Region: Pencillinase_R; cl17580
298654007873	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
298654007874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654007875	ATP binding site [chemical binding]; other site
298654007876	putative Mg++ binding site [ion binding]; other site
298654007877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654007878	nucleotide binding region [chemical binding]; other site
298654007879	ATP-binding site [chemical binding]; other site
298654007880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654007881	salt bridge; other site
298654007882	non-specific DNA binding site [nucleotide binding]; other site
298654007883	sequence-specific DNA binding site [nucleotide binding]; other site
298654007884	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654007885	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654007886	NAD(P) binding site [chemical binding]; other site
298654007887	active site
298654007888	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321
298654007889	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321
298654007890	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
298654007891	Family description; Region: UvrD_C_2; pfam13538
298654007892	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654007893	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654007894	SCP-2 sterol transfer family; Region: SCP2; cl01225
298654007895	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
298654007896	active site
298654007897	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
298654007898	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
298654007899	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
298654007900	substrate binding pocket [chemical binding]; other site
298654007901	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
298654007902	B12 binding site [chemical binding]; other site
298654007903	cobalt ligand [ion binding]; other site
298654007904	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
298654007905	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
298654007906	AAA domain; Region: AAA_17; pfam13207
298654007907	TIR domain; Region: TIR_2; pfam13676
298654007908	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
298654007909	catalytic residues [active]
298654007910	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
298654007911	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654007912	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654007913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654007914	binding surface
298654007915	TPR motif; other site
298654007916	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654007917	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654007918	binding surface
298654007919	TPR motif; other site
298654007920	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654007921	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
298654007922	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
298654007923	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
298654007924	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654007925	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654007926	active site
298654007927	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654007928	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654007929	TIR domain; Region: TIR_2; pfam13676
298654007930	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
298654007931	Citrate synthase; Region: Citrate_synt; pfam00285
298654007932	oxalacetate binding site [chemical binding]; other site
298654007933	citrylCoA binding site [chemical binding]; other site
298654007934	coenzyme A binding site [chemical binding]; other site
298654007935	catalytic triad [active]
298654007936	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654007937	Citrate synthase; Region: Citrate_synt; pfam00285
298654007938	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
298654007939	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
298654007940	oxalacetate binding site [chemical binding]; other site
298654007941	citrylCoA binding site [chemical binding]; other site
298654007942	coenzyme A binding site [chemical binding]; other site
298654007943	catalytic triad [active]
298654007944	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654007945	FAD binding domain; Region: FAD_binding_4; pfam01565
298654007946	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298654007947	Cysteine-rich domain; Region: CCG; pfam02754
298654007948	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
298654007949	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
298654007950	Walker A/P-loop; other site
298654007951	ATP binding site [chemical binding]; other site
298654007952	Q-loop/lid; other site
298654007953	ABC transporter signature motif; other site
298654007954	Walker B; other site
298654007955	D-loop; other site
298654007956	H-loop/switch region; other site
298654007957	TOBE domain; Region: TOBE_2; pfam08402
298654007958	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298654007959	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298654007960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654007961	putative PBP binding loops; other site
298654007962	dimer interface [polypeptide binding]; other site
298654007963	ABC-ATPase subunit interface; other site
298654007964	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654007965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654007966	dimer interface [polypeptide binding]; other site
298654007967	conserved gate region; other site
298654007968	putative PBP binding loops; other site
298654007969	ABC-ATPase subunit interface; other site
298654007970	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
298654007971	putative switch regulator; other site
298654007972	non-specific DNA interactions [nucleotide binding]; other site
298654007973	DNA binding site [nucleotide binding]
298654007974	sequence specific DNA binding site [nucleotide binding]; other site
298654007975	putative cAMP binding site [chemical binding]; other site
298654007976	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654007977	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654007978	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654007979	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654007980	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
298654007981	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654007982	active site
298654007983	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
298654007984	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
298654007985	active site
298654007986	trimer interface [polypeptide binding]; other site
298654007987	allosteric site; other site
298654007988	active site lid [active]
298654007989	hexamer (dimer of trimers) interface [polypeptide binding]; other site
298654007990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654007991	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654007992	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654007993	salt bridge; other site
298654007994	non-specific DNA binding site [nucleotide binding]; other site
298654007995	sequence-specific DNA binding site [nucleotide binding]; other site
298654007996	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
298654007997	lysozyme catalytic cleft [active]
298654007998	lysozyme catalytic site [active]
298654007999	Ca2+ binding site [ion binding]; other site
298654008000	C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441
298654008001	lysozyme catalytic cleft [active]
298654008002	lysozyme catalytic site [active]
298654008003	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654008004	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654008005	catalytic residue [active]
298654008006	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
298654008007	Phosphoesterase family; Region: Phosphoesterase; pfam04185
298654008008	Domain of unknown function (DUF756); Region: DUF756; pfam05506
298654008009	Domain of unknown function (DUF756); Region: DUF756; pfam05506
298654008010	Ras GTPase Activating Domain; Region: RasGAP; cl02569
298654008011	RAS interface [polypeptide binding]; other site
298654008012	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
298654008013	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654008014	active site residue [active]
298654008015	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654008016	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654008017	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654008018	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654008019	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
298654008020	putative hydrophobic ligand binding site [chemical binding]; other site
298654008021	CLM binding site; other site
298654008022	L1 loop; other site
298654008023	DNA binding site [nucleotide binding]
298654008024	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654008025	dimerization interface [polypeptide binding]; other site
298654008026	putative DNA binding site [nucleotide binding]; other site
298654008027	putative Zn2+ binding site [ion binding]; other site
298654008028	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654008029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654008030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654008031	DNA binding residues [nucleotide binding]
298654008032	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
298654008033	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
298654008034	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
298654008035	Soluble P-type ATPase [General function prediction only]; Region: COG4087
298654008036	K+-transporting ATPase, c chain; Region: KdpC; cl00944
298654008037	K+-transporting ATPase, c chain; Region: KdpC; cl00944
298654008038	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654008039	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654008040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654008041	sequence-specific DNA binding site [nucleotide binding]; other site
298654008042	salt bridge; other site
298654008043	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654008044	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654008045	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
298654008046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654008047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654008048	DNA binding residues [nucleotide binding]
298654008049	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654008050	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654008051	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
298654008052	active site clefts [active]
298654008053	zinc binding site [ion binding]; other site
298654008054	dimer interface [polypeptide binding]; other site
298654008055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654008056	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654008057	salt bridge; other site
298654008058	non-specific DNA binding site [nucleotide binding]; other site
298654008059	sequence-specific DNA binding site [nucleotide binding]; other site
298654008060	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654008061	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654008062	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654008063	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
298654008064	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654008065	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654008066	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654008067	active site
298654008068	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
298654008069	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
298654008070	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654008071	active site
298654008072	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654008073	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
298654008074	putative NAD(P) binding site [chemical binding]; other site
298654008075	Sulfatase; Region: Sulfatase; cl17466
298654008076	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
298654008077	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008078	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298654008079	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654008080	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654008081	catalytic residue [active]
298654008082	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654008083	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008084	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008085	Isochorismatase family; Region: Isochorismatase; pfam00857
298654008086	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
298654008087	catalytic triad [active]
298654008088	conserved cis-peptide bond; other site
298654008089	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298654008090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654008091	Walker A/P-loop; other site
298654008092	ATP binding site [chemical binding]; other site
298654008093	Q-loop/lid; other site
298654008094	ABC transporter signature motif; other site
298654008095	Walker B; other site
298654008096	D-loop; other site
298654008097	H-loop/switch region; other site
298654008098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654008099	dimer interface [polypeptide binding]; other site
298654008100	conserved gate region; other site
298654008101	putative PBP binding loops; other site
298654008102	ABC-ATPase subunit interface; other site
298654008103	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298654008104	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298654008105	substrate binding pocket [chemical binding]; other site
298654008106	membrane-bound complex binding site; other site
298654008107	hinge residues; other site
298654008108	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654008109	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654008110	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654008111	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654008112	Walker A/P-loop; other site
298654008113	ATP binding site [chemical binding]; other site
298654008114	Q-loop/lid; other site
298654008115	ABC transporter signature motif; other site
298654008116	Walker B; other site
298654008117	D-loop; other site
298654008118	H-loop/switch region; other site
298654008119	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654008120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298654008121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298654008122	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
298654008123	substrate binding pocket [chemical binding]; other site
298654008124	membrane-bound complex binding site; other site
298654008125	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654008126	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008128	putative substrate translocation pore; other site
298654008129	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
298654008130	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654008131	NAD(P) binding site [chemical binding]; other site
298654008132	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298654008133	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
298654008134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008135	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654008136	putative substrate translocation pore; other site
298654008137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008139	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654008140	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298654008141	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654008142	classical (c) SDRs; Region: SDR_c; cd05233
298654008143	NAD(P) binding site [chemical binding]; other site
298654008144	active site
298654008145	Erythronolide synthase docking; Region: Docking; pfam08990
298654008146	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008147	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654008148	active site
298654008149	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654008150	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008152	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008153	Thioesterase; Region: PKS_TE; smart00824
298654008154	Erythronolide synthase docking; Region: Docking; pfam08990
298654008155	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654008156	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008157	active site
298654008158	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008159	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654008160	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654008161	putative NADP binding site [chemical binding]; other site
298654008162	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654008163	active site
298654008164	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008165	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654008166	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008167	active site
298654008168	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008169	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008170	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008171	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654008172	active site
298654008173	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654008174	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008175	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
298654008176	KR domain; Region: KR; pfam08659
298654008177	NADP binding site [chemical binding]; other site
298654008178	active site
298654008179	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008180	Erythronolide synthase docking; Region: Docking; pfam08990
298654008181	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008182	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654008183	active site
298654008184	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654008185	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008186	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
298654008187	NADP binding site [chemical binding]; other site
298654008188	KR domain; Region: KR; pfam08659
298654008189	active site
298654008190	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008191	Erythronolide synthase docking; Region: Docking; pfam08990
298654008192	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008193	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654008194	active site
298654008195	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654008196	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008197	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654008198	putative NADP binding site [chemical binding]; other site
298654008199	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654008200	active site
298654008201	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008202	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008203	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654008204	active site
298654008205	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654008206	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008207	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008208	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654008209	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654008210	active site
298654008211	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654008212	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654008213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008214	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
298654008215	Enoylreductase; Region: PKS_ER; smart00829
298654008216	NAD(P) binding site [chemical binding]; other site
298654008217	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654008218	putative NADP binding site [chemical binding]; other site
298654008219	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654008220	active site
298654008221	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654008222	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
298654008223	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
298654008224	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298654008225	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654008226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298654008227	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
298654008228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654008229	ABC-ATPase subunit interface; other site
298654008230	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
298654008231	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654008232	Walker A/P-loop; other site
298654008233	ATP binding site [chemical binding]; other site
298654008234	Q-loop/lid; other site
298654008235	ABC transporter signature motif; other site
298654008236	Walker B; other site
298654008237	D-loop; other site
298654008238	H-loop/switch region; other site
298654008239	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654008240	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
298654008241	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654008242	Walker A/P-loop; other site
298654008243	ATP binding site [chemical binding]; other site
298654008244	Q-loop/lid; other site
298654008245	ABC transporter signature motif; other site
298654008246	Walker B; other site
298654008247	D-loop; other site
298654008248	H-loop/switch region; other site
298654008249	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
298654008250	AAA ATPase domain; Region: AAA_16; pfam13191
298654008251	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654008252	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654008253	DNA binding residues [nucleotide binding]
298654008254	dimerization interface [polypeptide binding]; other site
298654008255	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654008256	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654008257	DNA binding residues [nucleotide binding]
298654008258	dimerization interface [polypeptide binding]; other site
298654008259	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654008260	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654008261	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654008262	classical (c) SDRs; Region: SDR_c; cd05233
298654008263	NAD(P) binding site [chemical binding]; other site
298654008264	active site
298654008265	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008266	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
298654008267	putative substrate translocation pore; other site
298654008268	Helix-turn-helix domain; Region: HTH_20; pfam12840
298654008269	dimerization interface [polypeptide binding]; other site
298654008270	putative DNA binding site [nucleotide binding]; other site
298654008271	putative Zn2+ binding site [ion binding]; other site
298654008272	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
298654008273	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
298654008274	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298654008275	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654008276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654008277	dimer interface [polypeptide binding]; other site
298654008278	conserved gate region; other site
298654008279	putative PBP binding loops; other site
298654008280	ABC-ATPase subunit interface; other site
298654008281	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
298654008282	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654008283	dimer interface [polypeptide binding]; other site
298654008284	conserved gate region; other site
298654008285	putative PBP binding loops; other site
298654008286	ABC-ATPase subunit interface; other site
298654008287	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
298654008288	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654008289	Walker A/P-loop; other site
298654008290	ATP binding site [chemical binding]; other site
298654008291	Q-loop/lid; other site
298654008292	ABC transporter signature motif; other site
298654008293	Walker B; other site
298654008294	D-loop; other site
298654008295	H-loop/switch region; other site
298654008296	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654008297	Walker A/P-loop; other site
298654008298	ATP binding site [chemical binding]; other site
298654008299	Q-loop/lid; other site
298654008300	ABC transporter signature motif; other site
298654008301	Walker B; other site
298654008302	D-loop; other site
298654008303	H-loop/switch region; other site
298654008304	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654008305	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298654008306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654008307	dimer interface [polypeptide binding]; other site
298654008308	conserved gate region; other site
298654008309	putative PBP binding loops; other site
298654008310	ABC-ATPase subunit interface; other site
298654008311	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298654008312	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
298654008313	Walker A/P-loop; other site
298654008314	ATP binding site [chemical binding]; other site
298654008315	Q-loop/lid; other site
298654008316	ABC transporter signature motif; other site
298654008317	Walker B; other site
298654008318	D-loop; other site
298654008319	H-loop/switch region; other site
298654008320	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654008321	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298654008322	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298654008323	substrate binding pocket [chemical binding]; other site
298654008324	membrane-bound complex binding site; other site
298654008325	hinge residues; other site
298654008326	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
298654008327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654008328	Coenzyme A binding pocket [chemical binding]; other site
298654008329	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654008330	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
298654008331	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654008332	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298654008333	anti sigma factor interaction site; other site
298654008334	regulatory phosphorylation site [posttranslational modification]; other site
298654008335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654008336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654008337	dimer interface [polypeptide binding]; other site
298654008338	phosphorylation site [posttranslational modification]
298654008339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654008340	ATP binding site [chemical binding]; other site
298654008341	Mg2+ binding site [ion binding]; other site
298654008342	G-X-G motif; other site
298654008343	Response regulator receiver domain; Region: Response_reg; pfam00072
298654008344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654008345	active site
298654008346	phosphorylation site [posttranslational modification]
298654008347	intermolecular recognition site; other site
298654008348	dimerization interface [polypeptide binding]; other site
298654008349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654008350	PAS domain; Region: PAS_9; pfam13426
298654008351	putative active site [active]
298654008352	heme pocket [chemical binding]; other site
298654008353	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654008354	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654008355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
298654008356	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654008357	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654008358	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654008359	Walker A/P-loop; other site
298654008360	ATP binding site [chemical binding]; other site
298654008361	Q-loop/lid; other site
298654008362	ABC transporter signature motif; other site
298654008363	Walker B; other site
298654008364	D-loop; other site
298654008365	H-loop/switch region; other site
298654008366	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654008367	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654008368	TM-ABC transporter signature motif; other site
298654008369	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654008370	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654008371	TM-ABC transporter signature motif; other site
298654008372	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654008373	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654008374	Walker A/P-loop; other site
298654008375	ATP binding site [chemical binding]; other site
298654008376	Q-loop/lid; other site
298654008377	ABC transporter signature motif; other site
298654008378	Walker B; other site
298654008379	D-loop; other site
298654008380	H-loop/switch region; other site
298654008381	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654008382	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654008383	putative ligand binding site [chemical binding]; other site
298654008384	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654008385	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008386	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654008387	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654008388	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654008389	classical (c) SDRs; Region: SDR_c; cd05233
298654008390	NAD(P) binding site [chemical binding]; other site
298654008391	active site
298654008392	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654008393	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654008394	TIR domain; Region: TIR_2; pfam13676
298654008395	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654008396	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654008397	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654008398	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654008399	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654008400	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
298654008401	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654008402	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654008403	DNA binding residues [nucleotide binding]
298654008404	dimerization interface [polypeptide binding]; other site
298654008405	Putative mono-oxygenase ydhR; Region: ydhR; cl07420
298654008406	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654008407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654008408	DNA-binding site [nucleotide binding]; DNA binding site
298654008409	FCD domain; Region: FCD; pfam07729
298654008410	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559
298654008411	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
298654008412	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
298654008413	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654008414	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654008415	Walker A/P-loop; other site
298654008416	ATP binding site [chemical binding]; other site
298654008417	Q-loop/lid; other site
298654008418	ABC transporter signature motif; other site
298654008419	Walker B; other site
298654008420	D-loop; other site
298654008421	H-loop/switch region; other site
298654008422	NMT1/THI5 like; Region: NMT1; pfam09084
298654008423	C2 domain; Region: C2; cl14603
298654008424	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
298654008425	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
298654008426	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
298654008427	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654008428	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
298654008429	TIR domain; Region: TIR_2; pfam13676
298654008430	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654008431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654008432	S-adenosylmethionine binding site [chemical binding]; other site
298654008433	Predicted membrane protein [Function unknown]; Region: COG2261
298654008434	phenylhydantoinase; Validated; Region: PRK08323
298654008435	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
298654008436	tetramer interface [polypeptide binding]; other site
298654008437	active site
298654008438	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
298654008439	Amidase; Region: Amidase; cl11426
298654008440	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654008441	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654008442	DNA-binding site [nucleotide binding]; DNA binding site
298654008443	FCD domain; Region: FCD; pfam07729
298654008444	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
298654008445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008446	putative substrate translocation pore; other site
298654008447	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008448	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008449	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654008450	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654008451	active site
298654008452	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654008453	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654008454	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008455	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008456	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008457	active site
298654008458	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654008459	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654008460	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654008461	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654008462	active site
298654008463	catalytic tetrad [active]
298654008464	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
298654008465	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
298654008466	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
298654008467	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654008468	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654008469	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654008470	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654008471	DNA binding residues [nucleotide binding]
298654008472	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654008473	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
298654008474	Putative sensor; Region: Sensor; pfam13796
298654008475	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654008476	Histidine kinase; Region: HisKA_3; pfam07730
298654008477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654008478	ATP binding site [chemical binding]; other site
298654008479	Mg2+ binding site [ion binding]; other site
298654008480	G-X-G motif; other site
298654008481	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654008482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654008483	active site
298654008484	phosphorylation site [posttranslational modification]
298654008485	intermolecular recognition site; other site
298654008486	dimerization interface [polypeptide binding]; other site
298654008487	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654008488	DNA binding residues [nucleotide binding]
298654008489	dimerization interface [polypeptide binding]; other site
298654008490	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654008491	dimerization interface [polypeptide binding]; other site
298654008492	putative DNA binding site [nucleotide binding]; other site
298654008493	putative Zn2+ binding site [ion binding]; other site
298654008494	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654008495	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654008496	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654008497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654008498	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298654008499	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
298654008500	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
298654008501	[4Fe-4S] binding site [ion binding]; other site
298654008502	molybdopterin cofactor binding site; other site
298654008503	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
298654008504	molybdopterin cofactor binding site; other site
298654008505	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
298654008506	Flavodoxin; Region: Flavodoxin_1; pfam00258
298654008507	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
298654008508	FAD binding pocket [chemical binding]; other site
298654008509	conserved FAD binding motif [chemical binding]; other site
298654008510	phosphate binding motif [ion binding]; other site
298654008511	beta-alpha-beta structure motif; other site
298654008512	NAD binding pocket [chemical binding]; other site
298654008513	hypothetical protein; Provisional; Region: PRK07906
298654008514	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
298654008515	putative metal binding site [ion binding]; other site
298654008516	aspartate aminotransferase; Provisional; Region: PRK08636
298654008517	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654008518	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654008519	homodimer interface [polypeptide binding]; other site
298654008520	catalytic residue [active]
298654008521	hypothetical protein; Validated; Region: PRK08223
298654008522	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
298654008523	ATP binding site [chemical binding]; other site
298654008524	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654008525	Coenzyme A binding pocket [chemical binding]; other site
298654008526	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654008527	dimerization interface [polypeptide binding]; other site
298654008528	putative DNA binding site [nucleotide binding]; other site
298654008529	putative Zn2+ binding site [ion binding]; other site
298654008530	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008531	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654008532	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
298654008533	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
298654008534	putative active site [active]
298654008535	putative metal binding site [ion binding]; other site
298654008536	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
298654008537	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
298654008538	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298654008539	minor groove reading motif; other site
298654008540	helix-hairpin-helix signature motif; other site
298654008541	active site
298654008542	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
298654008543	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
298654008544	zinc binding site [ion binding]; other site
298654008545	putative ligand binding site [chemical binding]; other site
298654008546	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
298654008547	TM-ABC transporter signature motif; other site
298654008548	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
298654008549	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654008550	Walker A/P-loop; other site
298654008551	ATP binding site [chemical binding]; other site
298654008552	Q-loop/lid; other site
298654008553	ABC transporter signature motif; other site
298654008554	Walker B; other site
298654008555	D-loop; other site
298654008556	H-loop/switch region; other site
298654008557	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
298654008558	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
298654008559	active site
298654008560	substrate binding site [chemical binding]; other site
298654008561	FMN binding site [chemical binding]; other site
298654008562	putative catalytic residues [active]
298654008563	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298654008564	homotrimer interaction site [polypeptide binding]; other site
298654008565	putative active site [active]
298654008566	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008567	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654008569	S-adenosylmethionine binding site [chemical binding]; other site
298654008570	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654008571	FAD binding domain; Region: FAD_binding_4; pfam01565
298654008572	Prephenate dehydratase; Region: PDT; pfam00800
298654008573	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
298654008574	putative L-Phe binding site [chemical binding]; other site
298654008575	Chorismate mutase type II; Region: CM_2; cl00693
298654008576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008577	putative substrate translocation pore; other site
298654008578	YciI-like protein; Reviewed; Region: PRK12863
298654008579	benzoate transport; Region: 2A0115; TIGR00895
298654008580	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008581	putative substrate translocation pore; other site
298654008582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654008583	putative substrate translocation pore; other site
298654008584	hypothetical protein; Provisional; Region: PRK07906
298654008585	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
298654008586	putative metal binding site [ion binding]; other site
298654008587	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
298654008588	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298654008589	G1 box; other site
298654008590	GTP/Mg2+ binding site [chemical binding]; other site
298654008591	G2 box; other site
298654008592	Switch I region; other site
298654008593	G3 box; other site
298654008594	Switch II region; other site
298654008595	G4 box; other site
298654008596	G5 box; other site
298654008597	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
298654008598	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
298654008599	PAS fold; Region: PAS_4; pfam08448
298654008600	GAF domain; Region: GAF_2; pfam13185
298654008601	GAF domain; Region: GAF_3; pfam13492
298654008602	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654008603	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654008604	metal binding site [ion binding]; metal-binding site
298654008605	active site
298654008606	I-site; other site
298654008607	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654008608	classical (c) SDRs; Region: SDR_c; cd05233
298654008609	NAD(P) binding site [chemical binding]; other site
298654008610	active site
298654008611	tetracycline repressor protein TetR; Provisional; Region: PRK13756
298654008612	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008613	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654008614	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
298654008615	CoA binding domain; Region: CoA_binding_2; pfam13380
298654008616	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
298654008617	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
298654008618	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654008619	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298654008620	Beta-lactamase; Region: Beta-lactamase; pfam00144
298654008621	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654008622	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008623	substrate binding site [chemical binding]; other site
298654008624	oxyanion hole (OAH) forming residues; other site
298654008625	trimer interface [polypeptide binding]; other site
298654008626	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654008627	Cytochrome P450; Region: p450; cl12078
298654008628	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
298654008629	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654008630	catalytic loop [active]
298654008631	iron binding site [ion binding]; other site
298654008632	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
298654008633	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654008634	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654008635	putative active site [active]
298654008636	putative substrate binding site [chemical binding]; other site
298654008637	ATP binding site [chemical binding]; other site
298654008638	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654008639	classical (c) SDRs; Region: SDR_c; cd05233
298654008640	NAD(P) binding site [chemical binding]; other site
298654008641	active site
298654008642	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008643	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008644	active site
298654008645	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654008646	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654008647	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008648	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654008649	NAD(P) binding site [chemical binding]; other site
298654008650	active site
298654008651	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
298654008652	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654008653	dimer interface [polypeptide binding]; other site
298654008654	active site
298654008655	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008656	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008657	active site
298654008658	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008659	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654008660	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008661	active site
298654008662	enoyl-CoA hydratase; Provisional; Region: PRK05864
298654008663	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008664	substrate binding site [chemical binding]; other site
298654008665	oxyanion hole (OAH) forming residues; other site
298654008666	trimer interface [polypeptide binding]; other site
298654008667	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654008668	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654008669	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654008670	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008671	substrate binding site [chemical binding]; other site
298654008672	oxyanion hole (OAH) forming residues; other site
298654008673	trimer interface [polypeptide binding]; other site
298654008674	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008675	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654008676	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008677	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008678	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008679	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008680	active site
298654008681	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654008682	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008683	substrate binding site [chemical binding]; other site
298654008684	oxyanion hole (OAH) forming residues; other site
298654008685	trimer interface [polypeptide binding]; other site
298654008686	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654008687	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654008688	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654008689	Putative cyclase; Region: Cyclase; pfam04199
298654008690	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654008691	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654008692	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654008693	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654008694	active site
298654008695	metal binding site [ion binding]; metal-binding site
298654008696	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654008697	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654008698	classical (c) SDRs; Region: SDR_c; cd05233
298654008699	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
298654008700	NAD(P) binding site [chemical binding]; other site
298654008701	active site
298654008702	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654008703	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654008704	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654008705	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654008706	Walker A/P-loop; other site
298654008707	ATP binding site [chemical binding]; other site
298654008708	Q-loop/lid; other site
298654008709	ABC transporter signature motif; other site
298654008710	Walker B; other site
298654008711	D-loop; other site
298654008712	H-loop/switch region; other site
298654008713	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654008714	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654008715	Walker A/P-loop; other site
298654008716	ATP binding site [chemical binding]; other site
298654008717	Q-loop/lid; other site
298654008718	ABC transporter signature motif; other site
298654008719	Walker B; other site
298654008720	D-loop; other site
298654008721	H-loop/switch region; other site
298654008722	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654008723	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654008724	TM-ABC transporter signature motif; other site
298654008725	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654008726	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654008727	TM-ABC transporter signature motif; other site
298654008728	hypothetical protein; Provisional; Region: PRK06194
298654008729	classical (c) SDRs; Region: SDR_c; cd05233
298654008730	NAD(P) binding site [chemical binding]; other site
298654008731	active site
298654008732	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008734	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654008735	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008736	enoyl-CoA hydratase; Provisional; Region: PRK06190
298654008737	substrate binding site [chemical binding]; other site
298654008738	oxyanion hole (OAH) forming residues; other site
298654008739	trimer interface [polypeptide binding]; other site
298654008740	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654008741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008742	NAD(P) binding site [chemical binding]; other site
298654008743	active site
298654008744	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654008745	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008746	substrate binding site [chemical binding]; other site
298654008747	oxyanion hole (OAH) forming residues; other site
298654008748	trimer interface [polypeptide binding]; other site
298654008749	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
298654008750	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
298654008751	ligand binding site [chemical binding]; other site
298654008752	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
298654008753	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654008754	active site
298654008755	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298654008756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654008757	Walker A/P-loop; other site
298654008758	ATP binding site [chemical binding]; other site
298654008759	Q-loop/lid; other site
298654008760	ABC transporter signature motif; other site
298654008761	Walker B; other site
298654008762	D-loop; other site
298654008763	H-loop/switch region; other site
298654008764	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298654008765	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654008766	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654008767	TM-ABC transporter signature motif; other site
298654008768	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654008769	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654008770	DNA-binding site [nucleotide binding]; DNA binding site
298654008771	FCD domain; Region: FCD; pfam07729
298654008772	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654008773	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654008774	acyl-activating enzyme (AAE) consensus motif; other site
298654008775	AMP binding site [chemical binding]; other site
298654008776	active site
298654008777	CoA binding site [chemical binding]; other site
298654008778	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654008779	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654008780	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
298654008781	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654008782	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008783	substrate binding site [chemical binding]; other site
298654008784	oxyanion hole (OAH) forming residues; other site
298654008785	trimer interface [polypeptide binding]; other site
298654008786	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
298654008787	classical (c) SDRs; Region: SDR_c; cd05233
298654008788	NAD(P) binding site [chemical binding]; other site
298654008789	active site
298654008790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008791	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654008792	NAD(P) binding site [chemical binding]; other site
298654008793	active site
298654008794	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
298654008795	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654008796	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
298654008797	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654008798	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654008799	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
298654008800	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654008801	carboxyltransferase (CT) interaction site; other site
298654008802	biotinylation site [posttranslational modification]; other site
298654008803	TIGR03084 family protein; Region: TIGR03084
298654008804	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654008805	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
298654008806	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008807	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008808	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654008809	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654008810	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654008811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008813	short chain dehydrogenase; Provisional; Region: PRK07890
298654008814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008815	NAD(P) binding site [chemical binding]; other site
298654008816	active site
298654008817	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654008818	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654008819	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008820	NAD(P) binding site [chemical binding]; other site
298654008821	active site
298654008822	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654008823	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654008824	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
298654008825	tetramerization interface [polypeptide binding]; other site
298654008826	active site
298654008827	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654008828	MarR family; Region: MarR; pfam01047
298654008829	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
298654008830	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
298654008831	Cl- selectivity filter; other site
298654008832	Cl- binding residues [ion binding]; other site
298654008833	pore gating glutamate residue; other site
298654008834	dimer interface [polypeptide binding]; other site
298654008835	Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234
298654008836	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654008837	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654008838	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654008839	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654008840	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654008841	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654008842	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654008843	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654008844	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654008845	metal binding site [ion binding]; metal-binding site
298654008846	active site
298654008847	I-site; other site
298654008848	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654008849	acyl-CoA synthetase; Provisional; Region: PRK13388
298654008850	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
298654008851	acyl-activating enzyme (AAE) consensus motif; other site
298654008852	putative AMP binding site [chemical binding]; other site
298654008853	putative active site [active]
298654008854	putative CoA binding site [chemical binding]; other site
298654008855	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
298654008856	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
298654008857	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
298654008858	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
298654008859	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
298654008860	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654008861	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654008862	active site
298654008863	metal binding site [ion binding]; metal-binding site
298654008864	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008865	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008866	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008867	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008868	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008869	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008870	active site
298654008871	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008872	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654008873	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654008874	active site
298654008875	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654008876	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008877	active site
298654008878	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654008879	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654008880	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654008881	active site
298654008882	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654008883	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654008884	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654008885	DNA-binding site [nucleotide binding]; DNA binding site
298654008886	FCD domain; Region: FCD; pfam07729
298654008887	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654008888	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654008889	NAD binding site [chemical binding]; other site
298654008890	catalytic residues [active]
298654008891	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654008892	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654008893	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654008894	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
298654008895	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
298654008896	CysD dimerization site [polypeptide binding]; other site
298654008897	G1 box; other site
298654008898	putative GEF interaction site [polypeptide binding]; other site
298654008899	GTP/Mg2+ binding site [chemical binding]; other site
298654008900	Switch I region; other site
298654008901	G2 box; other site
298654008902	G3 box; other site
298654008903	Switch II region; other site
298654008904	G4 box; other site
298654008905	G5 box; other site
298654008906	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
298654008907	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
298654008908	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
298654008909	ligand-binding site [chemical binding]; other site
298654008910	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
298654008911	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298654008912	Active Sites [active]
298654008913	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654008914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654008915	NAD(P) binding site [chemical binding]; other site
298654008916	active site
298654008917	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
298654008918	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008919	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008920	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654008921	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654008922	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008923	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654008924	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654008925	substrate binding site [chemical binding]; other site
298654008926	oxyanion hole (OAH) forming residues; other site
298654008927	trimer interface [polypeptide binding]; other site
298654008928	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654008929	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654008930	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654008931	Cytochrome P450; Region: p450; cl12078
298654008932	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654008933	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654008934	NAD binding site [chemical binding]; other site
298654008935	catalytic residues [active]
298654008936	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654008937	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654008938	lipid-transfer protein; Provisional; Region: PRK07855
298654008939	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654008940	active site
298654008941	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
298654008942	active site
298654008943	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654008944	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654008945	putative ligand binding site [chemical binding]; other site
298654008946	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654008947	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654008948	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654008949	acyl-activating enzyme (AAE) consensus motif; other site
298654008950	AMP binding site [chemical binding]; other site
298654008951	active site
298654008952	CoA binding site [chemical binding]; other site
298654008953	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
298654008954	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654008955	NAD binding site [chemical binding]; other site
298654008956	catalytic Zn binding site [ion binding]; other site
298654008957	substrate binding site [chemical binding]; other site
298654008958	structural Zn binding site [ion binding]; other site
298654008959	Phosphotransferase enzyme family; Region: APH; pfam01636
298654008960	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654008961	putative active site [active]
298654008962	putative substrate binding site [chemical binding]; other site
298654008963	ATP binding site [chemical binding]; other site
298654008964	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654008965	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654008966	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654008967	acyl-activating enzyme (AAE) consensus motif; other site
298654008968	acyl-activating enzyme (AAE) consensus motif; other site
298654008969	AMP binding site [chemical binding]; other site
298654008970	active site
298654008971	CoA binding site [chemical binding]; other site
298654008972	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
298654008973	active site 2 [active]
298654008974	active site 1 [active]
298654008975	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654008976	active site 2 [active]
298654008977	active site 1 [active]
298654008978	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654008979	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654008980	Cytochrome P450; Region: p450; cl12078
298654008981	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
298654008982	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
298654008983	NADP binding site [chemical binding]; other site
298654008984	dimer interface [polypeptide binding]; other site
298654008985	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654008986	classical (c) SDRs; Region: SDR_c; cd05233
298654008987	NAD(P) binding site [chemical binding]; other site
298654008988	active site
298654008989	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654008990	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654008991	putative AMP binding site [chemical binding]; other site
298654008992	putative active site [active]
298654008993	acyl-activating enzyme (AAE) consensus motif; other site
298654008994	putative CoA binding site [chemical binding]; other site
298654008995	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654008996	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654008997	NAD binding site [chemical binding]; other site
298654008998	catalytic residues [active]
298654008999	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
298654009000	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
298654009001	active site
298654009002	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654009003	enoyl-CoA hydratase; Provisional; Region: PRK07799
298654009004	substrate binding site [chemical binding]; other site
298654009005	oxyanion hole (OAH) forming residues; other site
298654009006	trimer interface [polypeptide binding]; other site
298654009007	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
298654009008	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
298654009009	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298654009010	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
298654009011	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654009012	substrate binding site [chemical binding]; other site
298654009013	activation loop (A-loop); other site
298654009014	AAA ATPase domain; Region: AAA_16; pfam13191
298654009015	Predicted ATPase [General function prediction only]; Region: COG3899
298654009016	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654009017	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654009018	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654009019	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654009020	metal binding site [ion binding]; metal-binding site
298654009021	active site
298654009022	I-site; other site
298654009023	Protein of unknown function (DUF664); Region: DUF664; pfam04978
298654009024	DinB superfamily; Region: DinB_2; pfam12867
298654009025	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
298654009026	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
298654009027	nucleotide binding site [chemical binding]; other site
298654009028	NEF interaction site [polypeptide binding]; other site
298654009029	SBD interface [polypeptide binding]; other site
298654009030	TIR domain; Region: TIR_2; pfam13676
298654009031	TM1410 hypothetical-related protein; Region: DUF297; cl00997
298654009032	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
298654009033	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654009034	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654009035	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654009036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654009037	putative substrate translocation pore; other site
298654009038	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009039	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009040	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654009041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654009042	S-adenosylmethionine binding site [chemical binding]; other site
298654009043	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654009044	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
298654009045	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
298654009046	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
298654009047	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
298654009048	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654009049	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298654009050	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
298654009051	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
298654009052	active site
298654009053	substrate binding site [chemical binding]; other site
298654009054	Mg2+ binding site [ion binding]; other site
298654009055	TIGR02594 family protein; Region: TIGR02594
298654009056	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
298654009057	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654009058	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654009059	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654009060	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654009061	Domain of unknown function DUF11; Region: DUF11; cl17728
298654009062	NB-ARC domain; Region: NB-ARC; pfam00931
298654009063	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654009064	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654009065	structural tetrad; other site
298654009066	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
298654009067	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
298654009068	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
298654009069	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654009070	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654009071	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654009072	active site
298654009073	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654009074	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654009075	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
298654009076	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654009077	NADP binding site [chemical binding]; other site
298654009078	active site
298654009079	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654009080	Thioesterase; Region: PKS_TE; smart00824
298654009081	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654009082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654009083	DNA binding residues [nucleotide binding]
298654009084	MMPL family; Region: MMPL; pfam03176
298654009085	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
298654009086	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654009087	MMPL family; Region: MMPL; pfam03176
298654009088	GAF domain; Region: GAF; cl17456
298654009089	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654009090	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654009091	DNA binding residues [nucleotide binding]
298654009092	dimerization interface [polypeptide binding]; other site
298654009093	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
298654009094	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654009095	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
298654009096	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298654009097	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298654009098	putative acyl-acceptor binding pocket; other site
298654009099	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654009100	Cytochrome P450; Region: p450; cl12078
298654009101	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654009102	classical (c) SDRs; Region: SDR_c; cd05233
298654009103	NAD(P) binding site [chemical binding]; other site
298654009104	active site
298654009105	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
298654009106	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009107	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298654009108	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298654009109	Walker A/P-loop; other site
298654009110	ATP binding site [chemical binding]; other site
298654009111	Q-loop/lid; other site
298654009112	ABC transporter signature motif; other site
298654009113	Walker B; other site
298654009114	D-loop; other site
298654009115	H-loop/switch region; other site
298654009116	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298654009117	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654009118	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654009119	TM-ABC transporter signature motif; other site
298654009120	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654009121	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654009122	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654009123	acyl-activating enzyme (AAE) consensus motif; other site
298654009124	acyl-activating enzyme (AAE) consensus motif; other site
298654009125	putative AMP binding site [chemical binding]; other site
298654009126	putative active site [active]
298654009127	putative CoA binding site [chemical binding]; other site
298654009128	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654009129	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654009130	substrate binding site [chemical binding]; other site
298654009131	oxyanion hole (OAH) forming residues; other site
298654009132	trimer interface [polypeptide binding]; other site
298654009133	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654009134	active site
298654009135	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654009136	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654009137	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654009138	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654009139	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654009140	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654009141	tetracycline repressor protein TetR; Provisional; Region: PRK13756
298654009142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009143	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654009144	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654009145	[2Fe-2S] cluster binding site [ion binding]; other site
298654009146	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
298654009147	putative alpha subunit interface [polypeptide binding]; other site
298654009148	putative active site [active]
298654009149	putative substrate binding site [chemical binding]; other site
298654009150	Fe binding site [ion binding]; other site
298654009151	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654009152	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654009153	NAD(P) binding site [chemical binding]; other site
298654009154	catalytic residues [active]
298654009155	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654009156	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654009157	active site
298654009158	enoyl-CoA hydratase; Provisional; Region: PRK05864
298654009159	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654009160	substrate binding site [chemical binding]; other site
298654009161	oxyanion hole (OAH) forming residues; other site
298654009162	trimer interface [polypeptide binding]; other site
298654009163	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654009164	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654009165	putative ligand binding site [chemical binding]; other site
298654009166	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654009167	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654009168	NAD binding site [chemical binding]; other site
298654009169	catalytic residues [active]
298654009170	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654009171	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654009172	lipid-transfer protein; Provisional; Region: PRK07855
298654009173	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654009174	active site
298654009175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009176	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654009177	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
298654009178	FMN binding site [chemical binding]; other site
298654009179	dimer interface [polypeptide binding]; other site
298654009180	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654009181	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654009182	active site
298654009183	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654009184	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654009185	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654009186	Cytochrome P450; Region: p450; cl12078
298654009187	classical (c) SDRs; Region: SDR_c; cd05233
298654009188	NAD(P) binding site [chemical binding]; other site
298654009189	active site
298654009190	tetracycline repressor protein TetR; Provisional; Region: PRK13756
298654009191	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009192	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654009193	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654009194	Predicted acyl esterases [General function prediction only]; Region: COG2936
298654009195	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654009196	Protein kinase domain; Region: Pkinase; pfam00069
298654009197	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654009198	active site
298654009199	ATP binding site [chemical binding]; other site
298654009200	substrate binding site [chemical binding]; other site
298654009201	activation loop (A-loop); other site
298654009202	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
298654009203	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654009204	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654009205	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654009206	Cytochrome P450; Region: p450; cl12078
298654009207	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654009208	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654009209	NAD binding site [chemical binding]; other site
298654009210	catalytic residues [active]
298654009211	classical (c) SDRs; Region: SDR_c; cd05233
298654009212	NAD(P) binding site [chemical binding]; other site
298654009213	active site
298654009214	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654009215	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009216	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009217	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009218	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298654009219	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298654009220	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298654009221	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654009222	putative substrate translocation pore; other site
298654009223	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654009224	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654009225	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654009226	Walker A/P-loop; other site
298654009227	ATP binding site [chemical binding]; other site
298654009228	Q-loop/lid; other site
298654009229	ABC transporter signature motif; other site
298654009230	Walker B; other site
298654009231	D-loop; other site
298654009232	H-loop/switch region; other site
298654009233	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654009234	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654009235	TM-ABC transporter signature motif; other site
298654009236	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
298654009237	TM-ABC transporter signature motif; other site
298654009238	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654009239	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654009240	Walker A/P-loop; other site
298654009241	ATP binding site [chemical binding]; other site
298654009242	Q-loop/lid; other site
298654009243	ABC transporter signature motif; other site
298654009244	Walker B; other site
298654009245	D-loop; other site
298654009246	H-loop/switch region; other site
298654009247	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009248	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009249	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
298654009250	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
298654009251	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
298654009252	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
298654009253	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654009254	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654009255	DNA binding site [nucleotide binding]
298654009256	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
298654009257	dimerization interface [polypeptide binding]; other site
298654009258	ligand binding site [chemical binding]; other site
298654009259	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
298654009260	beta-galactosidase; Region: BGL; TIGR03356
298654009261	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654009262	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654009263	DNA binding site [nucleotide binding]
298654009264	domain linker motif; other site
298654009265	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
298654009266	dimerization interface [polypeptide binding]; other site
298654009267	ligand binding site [chemical binding]; other site
298654009268	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
298654009269	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
298654009270	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
298654009271	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
298654009272	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654009273	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654009274	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654009275	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654009276	putative ligand binding site [chemical binding]; other site
298654009277	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654009278	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654009279	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
298654009280	Walker A/P-loop; other site
298654009281	ATP binding site [chemical binding]; other site
298654009282	Q-loop/lid; other site
298654009283	ABC transporter signature motif; other site
298654009284	Walker B; other site
298654009285	D-loop; other site
298654009286	H-loop/switch region; other site
298654009287	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654009288	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654009289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009290	Walker A/P-loop; other site
298654009291	ATP binding site [chemical binding]; other site
298654009292	Q-loop/lid; other site
298654009293	ABC transporter signature motif; other site
298654009294	Walker B; other site
298654009295	D-loop; other site
298654009296	H-loop/switch region; other site
298654009297	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654009298	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
298654009299	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009300	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009301	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009302	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
298654009303	Lipase (class 2); Region: Lipase_2; pfam01674
298654009304	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654009305	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654009306	active site
298654009307	iron coordination sites [ion binding]; other site
298654009308	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654009309	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654009310	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009311	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
298654009312	inhibitor binding site; inhibition site
298654009313	active site
298654009314	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654009315	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009316	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009317	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298654009318	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298654009319	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
298654009320	putative CoA-transferase; Provisional; Region: PRK11430
298654009321	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654009322	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
298654009323	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298654009324	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298654009325	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
298654009326	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
298654009327	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
298654009328	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654009329	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654009330	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298654009331	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298654009332	Cobalt transport protein; Region: CbiQ; cl00463
298654009333	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
298654009334	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
298654009335	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
298654009336	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
298654009337	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
298654009338	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
298654009339	dimer interface [polypeptide binding]; other site
298654009340	active site
298654009341	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654009342	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654009343	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654009344	[2Fe-2S] cluster binding site [ion binding]; other site
298654009345	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654009346	alpha subunit interface [polypeptide binding]; other site
298654009347	active site
298654009348	substrate binding site [chemical binding]; other site
298654009349	Fe binding site [ion binding]; other site
298654009350	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654009351	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654009352	[2Fe-2S] cluster binding site [ion binding]; other site
298654009353	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654009354	alpha subunit interface [polypeptide binding]; other site
298654009355	active site
298654009356	substrate binding site [chemical binding]; other site
298654009357	Fe binding site [ion binding]; other site
298654009358	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
298654009359	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
298654009360	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
298654009361	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
298654009362	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654009363	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654009364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009365	Walker A/P-loop; other site
298654009366	ATP binding site [chemical binding]; other site
298654009367	Q-loop/lid; other site
298654009368	ABC transporter signature motif; other site
298654009369	Walker B; other site
298654009370	D-loop; other site
298654009371	H-loop/switch region; other site
298654009372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654009373	salt bridge; other site
298654009374	non-specific DNA binding site [nucleotide binding]; other site
298654009375	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654009376	sequence-specific DNA binding site [nucleotide binding]; other site
298654009377	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654009378	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654009379	active site
298654009380	catalytic tetrad [active]
298654009381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654009382	S-adenosylmethionine binding site [chemical binding]; other site
298654009383	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
298654009384	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
298654009385	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
298654009386	intersubunit interface [polypeptide binding]; other site
298654009387	active site
298654009388	Zn2+ binding site [ion binding]; other site
298654009389	ribulokinase; Provisional; Region: PRK04123
298654009390	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
298654009391	N- and C-terminal domain interface [polypeptide binding]; other site
298654009392	active site
298654009393	MgATP binding site [chemical binding]; other site
298654009394	catalytic site [active]
298654009395	metal binding site [ion binding]; metal-binding site
298654009396	carbohydrate binding site [chemical binding]; other site
298654009397	homodimer interface [polypeptide binding]; other site
298654009398	L-arabinose isomerase; Provisional; Region: PRK02929
298654009399	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
298654009400	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
298654009401	trimer interface [polypeptide binding]; other site
298654009402	putative substrate binding site [chemical binding]; other site
298654009403	putative metal binding site [ion binding]; other site
298654009404	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654009405	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654009406	DNA binding site [nucleotide binding]
298654009407	domain linker motif; other site
298654009408	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
298654009409	ligand binding site [chemical binding]; other site
298654009410	dimerization interface (open form) [polypeptide binding]; other site
298654009411	dimerization interface (closed form) [polypeptide binding]; other site
298654009412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654009413	S-adenosylmethionine binding site [chemical binding]; other site
298654009414	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
298654009415	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
298654009416	active site
298654009417	non-prolyl cis peptide bond; other site
298654009418	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654009419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009420	Walker A/P-loop; other site
298654009421	ATP binding site [chemical binding]; other site
298654009422	Q-loop/lid; other site
298654009423	ABC transporter signature motif; other site
298654009424	Walker B; other site
298654009425	D-loop; other site
298654009426	H-loop/switch region; other site
298654009427	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654009428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654009429	dimer interface [polypeptide binding]; other site
298654009430	conserved gate region; other site
298654009431	putative PBP binding loops; other site
298654009432	ABC-ATPase subunit interface; other site
298654009433	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
298654009434	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
298654009435	substrate binding pocket [chemical binding]; other site
298654009436	membrane-bound complex binding site; other site
298654009437	hinge residues; other site
298654009438	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654009439	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654009440	substrate binding pocket [chemical binding]; other site
298654009441	active site
298654009442	iron coordination sites [ion binding]; other site
298654009443	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654009444	active site residue [active]
298654009445	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654009446	active site residue [active]
298654009447	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654009448	active site residue [active]
298654009449	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654009450	active site residue [active]
298654009451	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
298654009452	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654009453	active site
298654009454	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654009455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654009456	NAD(P) binding site [chemical binding]; other site
298654009457	active site
298654009458	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654009459	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654009460	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654009461	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654009462	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654009463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009464	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
298654009465	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654009466	NAD(P) binding site [chemical binding]; other site
298654009467	active site
298654009468	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298654009469	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
298654009470	N-terminal domain interface [polypeptide binding]; other site
298654009471	dimer interface [polypeptide binding]; other site
298654009472	substrate binding pocket (H-site) [chemical binding]; other site
298654009473	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
298654009474	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654009475	putative NAD(P) binding site [chemical binding]; other site
298654009476	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009477	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009478	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654009479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654009480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
298654009481	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
298654009482	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654009483	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654009484	DNA binding residues [nucleotide binding]
298654009485	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
298654009486	TrkA-C domain; Region: TrkA_C; pfam02080
298654009487	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
298654009488	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
298654009489	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654009490	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654009491	NAD(P) binding site [chemical binding]; other site
298654009492	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009493	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009494	Uncharacterized conserved protein [Function unknown]; Region: COG1359
298654009495	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
298654009496	Phosphoesterase family; Region: Phosphoesterase; pfam04185
298654009497	Domain of unknown function (DUF756); Region: DUF756; pfam05506
298654009498	Domain of unknown function (DUF756); Region: DUF756; pfam05506
298654009499	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
298654009500	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654009501	substrate binding site [chemical binding]; other site
298654009502	oxyanion hole (OAH) forming residues; other site
298654009503	trimer interface [polypeptide binding]; other site
298654009504	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
298654009505	PAS domain S-box; Region: sensory_box; TIGR00229
298654009506	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654009507	putative active site [active]
298654009508	heme pocket [chemical binding]; other site
298654009509	PAS fold; Region: PAS_4; pfam08448
298654009510	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654009511	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654009512	metal binding site [ion binding]; metal-binding site
298654009513	active site
298654009514	I-site; other site
298654009515	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
298654009516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654009517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654009518	metal binding site [ion binding]; metal-binding site
298654009519	active site
298654009520	I-site; other site
298654009521	Protein of unknown function (DUF328); Region: DUF328; cl01143
298654009522	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
298654009523	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
298654009524	substrate binding pocket [chemical binding]; other site
298654009525	substrate-Mg2+ binding site; other site
298654009526	aspartate-rich region 1; other site
298654009527	active site lid residues [active]
298654009528	aspartate-rich region 2; other site
298654009529	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
298654009530	substrate binding pocket [chemical binding]; other site
298654009531	substrate-Mg2+ binding site; other site
298654009532	aspartate-rich region 1; other site
298654009533	aspartate-rich region 2; other site
298654009534	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654009535	ligand binding site [chemical binding]; other site
298654009536	flexible hinge region; other site
298654009537	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654009538	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654009539	sequence-specific DNA binding site [nucleotide binding]; other site
298654009540	salt bridge; other site
298654009541	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
298654009542	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654009543	active site
298654009544	Predicted esterase [General function prediction only]; Region: COG0627
298654009545	S-formylglutathione hydrolase; Region: PLN02442
298654009546	Nitronate monooxygenase; Region: NMO; pfam03060
298654009547	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
298654009548	FMN binding site [chemical binding]; other site
298654009549	substrate binding site [chemical binding]; other site
298654009550	putative catalytic residue [active]
298654009551	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
298654009552	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
298654009553	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
298654009554	dimer interface [polypeptide binding]; other site
298654009555	PYR/PP interface [polypeptide binding]; other site
298654009556	TPP binding site [chemical binding]; other site
298654009557	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298654009558	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
298654009559	TPP-binding site [chemical binding]; other site
298654009560	dimer interface [polypeptide binding]; other site
298654009561	Isochorismatase family; Region: Isochorismatase; pfam00857
298654009562	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
298654009563	catalytic triad [active]
298654009564	conserved cis-peptide bond; other site
298654009565	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
298654009566	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
298654009567	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654009568	NAD binding site [chemical binding]; other site
298654009569	catalytic Zn binding site [ion binding]; other site
298654009570	substrate binding site [chemical binding]; other site
298654009571	structural Zn binding site [ion binding]; other site
298654009572	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654009573	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654009574	ligand binding site [chemical binding]; other site
298654009575	Phosphotransferase enzyme family; Region: APH; pfam01636
298654009576	Ecdysteroid kinase; Region: EcKinase; cl17738
298654009577	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654009578	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654009579	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654009580	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009581	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654009582	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654009583	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654009584	Protein of unknown function, DUF488; Region: DUF488; cl01246
298654009585	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
298654009586	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
298654009587	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
298654009588	RNA/DNA hybrid binding site [nucleotide binding]; other site
298654009589	active site
298654009590	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654009591	catalytic core [active]
298654009592	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
298654009593	Putative zinc ribbon domain; Region: DUF164; pfam02591
298654009594	Uncharacterized conserved protein [Function unknown]; Region: COG0327
298654009595	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
298654009596	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009597	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009598	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654009599	TIGR01777 family protein; Region: yfcH
298654009600	NAD(P) binding site [chemical binding]; other site
298654009601	active site
298654009602	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654009603	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654009604	catalytic residue [active]
298654009605	MMPL family; Region: MMPL; pfam03176
298654009606	Isochorismatase family; Region: Isochorismatase; pfam00857
298654009607	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
298654009608	catalytic triad [active]
298654009609	conserved cis-peptide bond; other site
298654009610	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
298654009611	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
298654009612	conserved cys residue [active]
298654009613	TIR domain; Region: TIR_2; pfam13676
298654009614	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009616	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298654009617	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298654009618	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
298654009619	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
298654009620	dimerization interface [polypeptide binding]; other site
298654009621	NAD binding site [chemical binding]; other site
298654009622	ligand binding site [chemical binding]; other site
298654009623	catalytic site [active]
298654009624	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654009625	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654009626	active site
298654009627	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
298654009628	active site
298654009629	Zn binding site [ion binding]; other site
298654009630	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
298654009631	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
298654009632	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654009633	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
298654009634	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
298654009635	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
298654009636	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
298654009637	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
298654009638	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
298654009639	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654009640	DNA-binding site [nucleotide binding]; DNA binding site
298654009641	UTRA domain; Region: UTRA; cl17743
298654009642	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
298654009643	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
298654009644	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
298654009645	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
298654009646	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
298654009647	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654009648	Walker A/P-loop; other site
298654009649	ATP binding site [chemical binding]; other site
298654009650	Q-loop/lid; other site
298654009651	ABC transporter signature motif; other site
298654009652	Walker B; other site
298654009653	D-loop; other site
298654009654	H-loop/switch region; other site
298654009655	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
298654009656	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009657	Walker A/P-loop; other site
298654009658	ATP binding site [chemical binding]; other site
298654009659	Q-loop/lid; other site
298654009660	ABC transporter signature motif; other site
298654009661	Walker B; other site
298654009662	D-loop; other site
298654009663	H-loop/switch region; other site
298654009664	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
298654009665	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
298654009666	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654009667	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654009668	active site
298654009669	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
298654009670	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654009671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009672	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298654009673	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
298654009674	active site
298654009675	FMN binding site [chemical binding]; other site
298654009676	substrate binding site [chemical binding]; other site
298654009677	putative catalytic residue [active]
298654009678	Beta-lactamase; Region: Beta-lactamase; pfam00144
298654009679	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298654009680	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654009681	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
298654009682	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654009683	catalytic residue [active]
298654009684	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
298654009685	active site
298654009686	catalytic residues [active]
298654009687	metal binding site [ion binding]; metal-binding site
298654009688	RyR domain; Region: RyR; pfam02026
298654009689	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654009690	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
298654009691	dimer interface [polypeptide binding]; other site
298654009692	substrate binding site [chemical binding]; other site
298654009693	metal binding site [ion binding]; metal-binding site
298654009694	S-adenosylmethionine synthetase; Validated; Region: PRK05250
298654009695	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
298654009696	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
298654009697	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
298654009698	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654009699	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654009700	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654009701	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
298654009702	putative NAD(P) binding site [chemical binding]; other site
298654009703	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
298654009704	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654009705	Domain of unknown function (DUF427); Region: DUF427; pfam04248
298654009706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
298654009707	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
298654009708	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654009709	acyl-activating enzyme (AAE) consensus motif; other site
298654009710	AMP binding site [chemical binding]; other site
298654009711	active site
298654009712	CoA binding site [chemical binding]; other site
298654009713	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654009714	MarR family; Region: MarR_2; cl17246
298654009715	Cupin domain; Region: Cupin_2; cl17218
298654009716	TIR domain; Region: TIR_2; pfam13676
298654009717	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
298654009718	FAD binding domain; Region: FAD_binding_2; pfam00890
298654009719	Clp amino terminal domain; Region: Clp_N; pfam02861
298654009720	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654009721	TM-ABC transporter signature motif; other site
298654009722	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654009723	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654009724	TM-ABC transporter signature motif; other site
298654009725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009726	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
298654009727	Walker A/P-loop; other site
298654009728	ATP binding site [chemical binding]; other site
298654009729	Q-loop/lid; other site
298654009730	ABC transporter signature motif; other site
298654009731	Walker B; other site
298654009732	D-loop; other site
298654009733	H-loop/switch region; other site
298654009734	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654009735	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654009736	Walker A/P-loop; other site
298654009737	ATP binding site [chemical binding]; other site
298654009738	Q-loop/lid; other site
298654009739	ABC transporter signature motif; other site
298654009740	Walker B; other site
298654009741	D-loop; other site
298654009742	H-loop/switch region; other site
298654009743	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654009744	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654009745	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
298654009746	nudix motif; other site
298654009747	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
298654009748	active site
298654009749	catalytic residues [active]
298654009750	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
298654009751	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
298654009752	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
298654009753	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654009754	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654009755	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654009756	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009757	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
298654009758	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
298654009759	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
298654009760	DNA binding site [nucleotide binding]
298654009761	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654009762	AAA ATPase domain; Region: AAA_16; pfam13191
298654009763	Hemerythrin-like domain; Region: Hr-like; cd12108
298654009764	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654009765	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654009766	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654009767	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654009768	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654009769	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654009770	active site
298654009771	ATP binding site [chemical binding]; other site
298654009772	substrate binding site [chemical binding]; other site
298654009773	activation loop (A-loop); other site
298654009774	NPCBM/NEW2 domain; Region: NPCBM; cl07060
298654009775	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
298654009776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654009777	S-adenosylmethionine binding site [chemical binding]; other site
298654009778	HerA helicase [Replication, recombination, and repair]; Region: COG0433
298654009779	Domain of unknown function DUF87; Region: DUF87; pfam01935
298654009780	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654009781	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654009782	[2Fe-2S] cluster binding site [ion binding]; other site
298654009783	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654009784	hydrophobic ligand binding site; other site
298654009785	RNA polymerase factor sigma-70; Validated; Region: PRK08241
298654009786	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654009787	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654009788	DNA binding residues [nucleotide binding]
298654009789	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
298654009790	Methyltransferase domain; Region: Methyltransf_25; pfam13649
298654009791	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654009792	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654009793	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654009794	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654009795	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654009796	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654009797	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
298654009798	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298654009799	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654009800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298654009801	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
298654009802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654009803	dimer interface [polypeptide binding]; other site
298654009804	conserved gate region; other site
298654009805	ABC-ATPase subunit interface; other site
298654009806	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
298654009807	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654009808	Walker A/P-loop; other site
298654009809	ATP binding site [chemical binding]; other site
298654009810	Q-loop/lid; other site
298654009811	ABC transporter signature motif; other site
298654009812	Walker B; other site
298654009813	D-loop; other site
298654009814	H-loop/switch region; other site
298654009815	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
298654009816	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
298654009817	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654009818	Walker A/P-loop; other site
298654009819	ATP binding site [chemical binding]; other site
298654009820	Q-loop/lid; other site
298654009821	ABC transporter signature motif; other site
298654009822	Walker B; other site
298654009823	D-loop; other site
298654009824	H-loop/switch region; other site
298654009825	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654009826	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
298654009827	putative active site [active]
298654009828	putative catalytic site [active]
298654009829	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
298654009830	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654009831	active site
298654009832	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
298654009833	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654009834	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654009835	DNA-binding site [nucleotide binding]; DNA binding site
298654009836	FCD domain; Region: FCD; pfam07729
298654009837	Domain of unknown function (DUF385); Region: DUF385; cl04387
298654009838	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
298654009839	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654009840	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654009841	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654009842	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
298654009843	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
298654009844	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654009845	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654009846	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654009847	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298654009848	TIGR03086 family protein; Region: TIGR03086
298654009849	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654009850	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654009851	hydrophobic ligand binding site; other site
298654009852	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654009853	dimerization interface [polypeptide binding]; other site
298654009854	putative DNA binding site [nucleotide binding]; other site
298654009855	putative Zn2+ binding site [ion binding]; other site
298654009856	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
298654009857	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
298654009858	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654009859	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654009860	active site
298654009861	ATP binding site [chemical binding]; other site
298654009862	substrate binding site [chemical binding]; other site
298654009863	activation loop (A-loop); other site
298654009864	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654009865	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
298654009866	active site
298654009867	catalytic tetrad [active]
298654009868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654009869	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654009870	active site
298654009871	phosphorylation site [posttranslational modification]
298654009872	intermolecular recognition site; other site
298654009873	dimerization interface [polypeptide binding]; other site
298654009874	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654009875	DNA binding residues [nucleotide binding]
298654009876	dimerization interface [polypeptide binding]; other site
298654009877	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298654009878	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298654009879	MarR family; Region: MarR_2; cl17246
298654009880	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654009881	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
298654009882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009883	Walker A/P-loop; other site
298654009884	ATP binding site [chemical binding]; other site
298654009885	Q-loop/lid; other site
298654009886	ABC transporter signature motif; other site
298654009887	Walker B; other site
298654009888	D-loop; other site
298654009889	H-loop/switch region; other site
298654009890	ABC transporter; Region: ABC_tran_2; pfam12848
298654009891	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654009892	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
298654009893	methionine sulfoxide reductase B; Provisional; Region: PRK00222
298654009894	SelR domain; Region: SelR; pfam01641
298654009895	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
298654009896	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
298654009897	putative active site [active]
298654009898	catalytic triad [active]
298654009899	putative dimer interface [polypeptide binding]; other site
298654009900	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
298654009901	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
298654009902	Ligand binding site; other site
298654009903	Putative Catalytic site; other site
298654009904	DXD motif; other site
298654009905	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
298654009906	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654009907	active site
298654009908	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654009909	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654009910	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654009911	DNA binding residues [nucleotide binding]
298654009912	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654009913	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
298654009914	putative DNA binding site [nucleotide binding]; other site
298654009915	putative Zn2+ binding site [ion binding]; other site
298654009916	AsnC family; Region: AsnC_trans_reg; pfam01037
298654009917	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
298654009918	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
298654009919	active site
298654009920	metal binding site 1 [ion binding]; metal-binding site
298654009921	putative 5' ssDNA interaction site; other site
298654009922	metal binding site 3; metal-binding site
298654009923	metal binding site 2 [ion binding]; metal-binding site
298654009924	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
298654009925	putative DNA binding site [nucleotide binding]; other site
298654009926	putative metal binding site [ion binding]; other site
298654009927	Male sterility protein; Region: NAD_binding_4; pfam07993
298654009928	NAD(P) binding site [chemical binding]; other site
298654009929	active site
298654009930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654009931	active site
298654009932	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
298654009933	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
298654009934	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654009935	motif II; other site
298654009936	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654009937	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654009938	NAD(P) binding site [chemical binding]; other site
298654009939	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
298654009940	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298654009941	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298654009942	putative acyl-acceptor binding pocket; other site
298654009943	short chain dehydrogenase; Provisional; Region: PRK06197
298654009944	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654009945	NAD(P) binding site [chemical binding]; other site
298654009946	active site
298654009947	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654009948	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654009949	MarR family; Region: MarR_2; pfam12802
298654009950	TIR domain; Region: TIR_2; cl17458
298654009951	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654009952	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654009953	structural tetrad; other site
298654009954	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654009955	active site
298654009956	DNA binding site [nucleotide binding]
298654009957	Int/Topo IB signature motif; other site
298654009958	Clp amino terminal domain; Region: Clp_N; pfam02861
298654009959	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654009960	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654009961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654009962	Walker A/P-loop; other site
298654009963	ATP binding site [chemical binding]; other site
298654009964	Q-loop/lid; other site
298654009965	ABC transporter signature motif; other site
298654009966	Walker B; other site
298654009967	D-loop; other site
298654009968	H-loop/switch region; other site
298654009969	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654009970	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
298654009971	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654009972	Walker A/P-loop; other site
298654009973	ATP binding site [chemical binding]; other site
298654009974	Q-loop/lid; other site
298654009975	ABC transporter signature motif; other site
298654009976	Walker B; other site
298654009977	D-loop; other site
298654009978	H-loop/switch region; other site
298654009979	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
298654009980	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
298654009981	conserved cys residue [active]
298654009982	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654009983	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654009984	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654009985	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654009986	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654009987	DNA binding residues [nucleotide binding]
298654009988	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
298654009989	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654009990	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
298654009991	AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138
298654009992	Phosphotransferase enzyme family; Region: APH; pfam01636
298654009993	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654009994	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654009995	active site
298654009996	catalytic tetrad [active]
298654009997	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654009998	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654009999	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
298654010000	FAD binding site [chemical binding]; other site
298654010001	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
298654010002	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654010003	active site
298654010004	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654010005	SnoaL-like domain; Region: SnoaL_3; pfam13474
298654010006	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654010007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010008	putative substrate translocation pore; other site
298654010009	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654010010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654010011	active site
298654010012	phosphorylation site [posttranslational modification]
298654010013	intermolecular recognition site; other site
298654010014	dimerization interface [polypeptide binding]; other site
298654010015	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654010016	DNA binding residues [nucleotide binding]
298654010017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654010018	Histidine kinase; Region: HisKA_3; pfam07730
298654010019	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654010020	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298654010021	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654010022	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
298654010023	Walker A/P-loop; other site
298654010024	ATP binding site [chemical binding]; other site
298654010025	Q-loop/lid; other site
298654010026	ABC transporter signature motif; other site
298654010027	Walker B; other site
298654010028	D-loop; other site
298654010029	H-loop/switch region; other site
298654010030	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
298654010031	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
298654010032	active site
298654010033	Ap6A binding site [chemical binding]; other site
298654010034	nudix motif; other site
298654010035	metal binding site [ion binding]; metal-binding site
298654010036	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654010037	hydrophobic ligand binding site; other site
298654010038	hypothetical protein; Provisional; Region: PRK06834
298654010039	hypothetical protein; Provisional; Region: PRK07236
298654010040	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654010041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654010042	Coenzyme A binding pocket [chemical binding]; other site
298654010043	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
298654010044	Predicted ATPase [General function prediction only]; Region: COG3910
298654010045	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010046	Walker A/P-loop; other site
298654010047	ATP binding site [chemical binding]; other site
298654010048	Q-loop/lid; other site
298654010049	ABC transporter signature motif; other site
298654010050	Walker B; other site
298654010051	D-loop; other site
298654010052	H-loop/switch region; other site
298654010053	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654010054	MarR family; Region: MarR_2; cl17246
298654010055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010056	putative substrate translocation pore; other site
298654010057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010058	putative substrate translocation pore; other site
298654010059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010061	short chain dehydrogenase; Validated; Region: PRK08264
298654010062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654010063	NAD(P) binding site [chemical binding]; other site
298654010064	active site
298654010065	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
298654010066	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
298654010067	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
298654010068	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
298654010069	glutaminase active site [active]
298654010070	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
298654010071	dimer interface [polypeptide binding]; other site
298654010072	active site
298654010073	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
298654010074	active site
298654010075	dimer interface [polypeptide binding]; other site
298654010076	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654010077	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654010078	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654010079	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654010080	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654010081	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654010082	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654010083	substrate binding site [chemical binding]; other site
298654010084	oxyanion hole (OAH) forming residues; other site
298654010085	trimer interface [polypeptide binding]; other site
298654010086	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
298654010087	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010088	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654010089	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654010090	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654010091	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654010092	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654010093	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298654010094	Beta-lactamase; Region: Beta-lactamase; pfam00144
298654010095	active site
298654010096	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
298654010097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654010098	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654010099	NAD(P) binding site [chemical binding]; other site
298654010100	active site
298654010101	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654010102	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654010103	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654010104	DNA binding residues [nucleotide binding]
298654010105	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654010106	putative active site [active]
298654010107	putative substrate binding site [chemical binding]; other site
298654010108	ATP binding site [chemical binding]; other site
298654010109	Protein of unknown function (DUF1679); Region: DUF1679; pfam07914
298654010110	hypothetical protein; Provisional; Region: PRK02237
298654010111	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654010112	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654010113	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654010114	DNA binding residues [nucleotide binding]
298654010115	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654010116	active site
298654010117	ATP binding site [chemical binding]; other site
298654010118	substrate binding site [chemical binding]; other site
298654010119	activation loop (A-loop); other site
298654010120	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
298654010121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010122	Walker A/P-loop; other site
298654010123	ATP binding site [chemical binding]; other site
298654010124	Q-loop/lid; other site
298654010125	ABC transporter signature motif; other site
298654010126	Walker B; other site
298654010127	D-loop; other site
298654010128	H-loop/switch region; other site
298654010129	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
298654010130	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
298654010131	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654010132	active site
298654010133	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
298654010134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010135	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
298654010136	Walker A/P-loop; other site
298654010137	ATP binding site [chemical binding]; other site
298654010138	Q-loop/lid; other site
298654010139	ABC transporter signature motif; other site
298654010140	Walker B; other site
298654010141	D-loop; other site
298654010142	H-loop/switch region; other site
298654010143	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654010144	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654010145	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654010146	ATP binding site [chemical binding]; other site
298654010147	putative Mg++ binding site [ion binding]; other site
298654010148	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654010149	nucleotide binding region [chemical binding]; other site
298654010150	ATP-binding site [chemical binding]; other site
298654010151	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
298654010152	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
298654010153	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
298654010154	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
298654010155	WYL domain; Region: WYL; pfam13280
298654010156	Predicted transcriptional regulator [Transcription]; Region: COG2378
298654010157	WYL domain; Region: WYL; pfam13280
298654010158	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298654010159	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
298654010160	Dienelactone hydrolase family; Region: DLH; pfam01738
298654010161	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
298654010162	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
298654010163	active site
298654010164	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
298654010165	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
298654010166	active site
298654010167	Recombination endonuclease VII; Region: Endonuclease_7; pfam02945
298654010168	Recombination endonuclease VII; Region: Endonuclease_7; pfam02945
298654010169	Pup-like protein; Region: Pup; pfam05639
298654010170	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
298654010171	proteasome ATPase; Region: pup_AAA; TIGR03689
298654010172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654010173	Walker A motif; other site
298654010174	ATP binding site [chemical binding]; other site
298654010175	Walker B motif; other site
298654010176	arginine finger; other site
298654010177	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654010178	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
298654010179	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654010180	S-adenosylmethionine binding site [chemical binding]; other site
298654010181	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
298654010182	Peptidase family M50; Region: Peptidase_M50; pfam02163
298654010183	active site
298654010184	putative substrate binding region [chemical binding]; other site
298654010185	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
298654010186	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654010187	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654010188	Walker A/P-loop; other site
298654010189	ATP binding site [chemical binding]; other site
298654010190	Q-loop/lid; other site
298654010191	ABC transporter signature motif; other site
298654010192	Walker B; other site
298654010193	D-loop; other site
298654010194	H-loop/switch region; other site
298654010195	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298654010196	FtsX-like permease family; Region: FtsX; pfam02687
298654010197	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298654010198	FtsX-like permease family; Region: FtsX; pfam02687
298654010199	PAC2 family; Region: PAC2; pfam09754
298654010200	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
298654010201	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298654010202	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654010203	motif II; other site
298654010204	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654010205	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
298654010206	active site
298654010207	HIGH motif; other site
298654010208	nucleotide binding site [chemical binding]; other site
298654010209	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654010210	active site
298654010211	KMSKS motif; other site
298654010212	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
298654010213	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654010214	catalytic core [active]
298654010215	conserved hypothetical protein; Region: TIGR03843
298654010216	AAA domain; Region: AAA_30; pfam13604
298654010217	Family description; Region: UvrD_C_2; pfam13538
298654010218	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
298654010219	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
298654010220	Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188
298654010221	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654010222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654010223	sequence-specific DNA binding site [nucleotide binding]; other site
298654010224	salt bridge; other site
298654010225	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654010226	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654010227	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654010228	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654010229	Walker A/P-loop; other site
298654010230	ATP binding site [chemical binding]; other site
298654010231	Q-loop/lid; other site
298654010232	ABC transporter signature motif; other site
298654010233	Walker B; other site
298654010234	D-loop; other site
298654010235	H-loop/switch region; other site
298654010236	FOG: CBS domain [General function prediction only]; Region: COG0517
298654010237	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
298654010238	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
298654010239	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654010240	active site
298654010241	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
298654010242	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654010243	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654010244	NAD(P) binding site [chemical binding]; other site
298654010245	Septum formation; Region: Septum_form; pfam13845
298654010246	Septum formation; Region: Septum_form; pfam13845
298654010247	Septum formation; Region: Septum_form; pfam13845
298654010248	Septum formation; Region: Septum_form; pfam13845
298654010249	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
298654010250	Amidase; Region: Amidase; cl11426
298654010251	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654010252	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654010253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010254	Walker A/P-loop; other site
298654010255	ATP binding site [chemical binding]; other site
298654010256	Q-loop/lid; other site
298654010257	ABC transporter signature motif; other site
298654010258	Walker B; other site
298654010259	D-loop; other site
298654010260	H-loop/switch region; other site
298654010261	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654010262	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
298654010263	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654010264	NAD binding site [chemical binding]; other site
298654010265	catalytic Zn binding site [ion binding]; other site
298654010266	substrate binding site [chemical binding]; other site
298654010267	structural Zn binding site [ion binding]; other site
298654010268	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298654010269	membrane-bound complex binding site; other site
298654010270	hinge residues; other site
298654010271	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654010272	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654010273	active site
298654010274	iron coordination sites [ion binding]; other site
298654010275	substrate binding pocket [chemical binding]; other site
298654010276	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654010277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654010278	dimer interface [polypeptide binding]; other site
298654010279	conserved gate region; other site
298654010280	putative PBP binding loops; other site
298654010281	ABC-ATPase subunit interface; other site
298654010282	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654010283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010284	Walker A/P-loop; other site
298654010285	ATP binding site [chemical binding]; other site
298654010286	Q-loop/lid; other site
298654010287	ABC transporter signature motif; other site
298654010288	Walker B; other site
298654010289	D-loop; other site
298654010290	H-loop/switch region; other site
298654010291	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010292	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010293	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654010294	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654010295	active site
298654010296	iron coordination sites [ion binding]; other site
298654010297	substrate binding pocket [chemical binding]; other site
298654010298	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
298654010299	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
298654010300	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
298654010301	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654010302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010303	Walker A/P-loop; other site
298654010304	ATP binding site [chemical binding]; other site
298654010305	Q-loop/lid; other site
298654010306	ABC transporter signature motif; other site
298654010307	Walker B; other site
298654010308	D-loop; other site
298654010309	H-loop/switch region; other site
298654010310	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
298654010311	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654010312	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
298654010313	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
298654010314	NodB motif; other site
298654010315	putative active site [active]
298654010316	putative catalytic site [active]
298654010317	putative Zn binding site [ion binding]; other site
298654010318	lipid-transfer protein; Provisional; Region: PRK08256
298654010319	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654010320	active site
298654010321	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654010322	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654010323	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
298654010324	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654010325	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
298654010326	active site
298654010327	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
298654010328	non-prolyl cis peptide bond; other site
298654010329	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654010330	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
298654010331	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654010332	CoenzymeA binding site [chemical binding]; other site
298654010333	subunit interaction site [polypeptide binding]; other site
298654010334	PHB binding site; other site
298654010335	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654010336	active site 2 [active]
298654010337	active site 1 [active]
298654010338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654010339	PAS domain; Region: PAS_9; pfam13426
298654010340	putative active site [active]
298654010341	heme pocket [chemical binding]; other site
298654010342	GAF domain; Region: GAF; pfam01590
298654010343	GAF domain; Region: GAF_2; pfam13185
298654010344	Histidine kinase; Region: HisKA_3; pfam07730
298654010345	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654010346	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654010347	substrate binding pocket [chemical binding]; other site
298654010348	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654010349	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654010350	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654010351	hypothetical protein; Provisional; Region: PRK06847
298654010352	hypothetical protein; Provisional; Region: PRK07236
298654010353	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654010354	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654010355	MarR family; Region: MarR; pfam01047
298654010356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010357	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
298654010358	Walker A/P-loop; other site
298654010359	ATP binding site [chemical binding]; other site
298654010360	Q-loop/lid; other site
298654010361	ABC transporter signature motif; other site
298654010362	Walker B; other site
298654010363	D-loop; other site
298654010364	H-loop/switch region; other site
298654010365	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
298654010366	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654010367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654010368	S-adenosylmethionine binding site [chemical binding]; other site
298654010369	FAD binding domain; Region: FAD_binding_4; pfam01565
298654010370	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
298654010371	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654010372	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654010373	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654010374	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654010375	active site
298654010376	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654010377	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654010378	[2Fe-2S] cluster binding site [ion binding]; other site
298654010379	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
298654010380	putative alpha subunit interface [polypeptide binding]; other site
298654010381	putative active site [active]
298654010382	putative substrate binding site [chemical binding]; other site
298654010383	Fe binding site [ion binding]; other site
298654010384	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298654010385	PYR/PP interface [polypeptide binding]; other site
298654010386	dimer interface [polypeptide binding]; other site
298654010387	TPP binding site [chemical binding]; other site
298654010388	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298654010389	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
298654010390	TPP-binding site [chemical binding]; other site
298654010391	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
298654010392	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654010393	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
298654010394	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
298654010395	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
298654010396	Walker A/P-loop; other site
298654010397	ATP binding site [chemical binding]; other site
298654010398	Q-loop/lid; other site
298654010399	ABC transporter signature motif; other site
298654010400	Walker B; other site
298654010401	D-loop; other site
298654010402	H-loop/switch region; other site
298654010403	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
298654010404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654010405	dimer interface [polypeptide binding]; other site
298654010406	conserved gate region; other site
298654010407	putative PBP binding loops; other site
298654010408	ABC-ATPase subunit interface; other site
298654010409	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
298654010410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654010411	dimer interface [polypeptide binding]; other site
298654010412	conserved gate region; other site
298654010413	putative PBP binding loops; other site
298654010414	ABC-ATPase subunit interface; other site
298654010415	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
298654010416	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
298654010417	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
298654010418	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
298654010419	urea carboxylase; Region: urea_carbox; TIGR02712
298654010420	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654010421	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654010422	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
298654010423	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
298654010424	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
298654010425	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654010426	carboxyltransferase (CT) interaction site; other site
298654010427	biotinylation site [posttranslational modification]; other site
298654010428	allophanate hydrolase; Provisional; Region: PRK08186
298654010429	Amidase; Region: Amidase; cl11426
298654010430	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010432	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
298654010433	agmatinase; Region: agmatinase; TIGR01230
298654010434	oligomer interface [polypeptide binding]; other site
298654010435	putative active site [active]
298654010436	Mn binding site [ion binding]; other site
298654010437	Benzoate membrane transport protein; Region: BenE; pfam03594
298654010438	benzoate transporter; Region: benE; TIGR00843
298654010439	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654010440	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654010441	non-specific DNA binding site [nucleotide binding]; other site
298654010442	salt bridge; other site
298654010443	sequence-specific DNA binding site [nucleotide binding]; other site
298654010444	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
298654010445	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654010446	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654010447	active site
298654010448	Phosphotransferase enzyme family; Region: APH; pfam01636
298654010449	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654010450	putative active site [active]
298654010451	putative substrate binding site [chemical binding]; other site
298654010452	ATP binding site [chemical binding]; other site
298654010453	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654010454	EthD domain; Region: EthD; pfam07110
298654010455	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654010456	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
298654010457	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
298654010458	conserved cys residue [active]
298654010459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654010460	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
298654010461	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
298654010462	conserved cys residue [active]
298654010463	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654010464	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654010465	metal binding site [ion binding]; metal-binding site
298654010466	active site
298654010467	I-site; other site
298654010468	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
298654010469	Isochorismatase family; Region: Isochorismatase; pfam00857
298654010470	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
298654010471	catalytic triad [active]
298654010472	conserved cis-peptide bond; other site
298654010473	Clp protease ATP binding subunit; Region: clpC; CHL00095
298654010474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010475	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654010476	putative substrate translocation pore; other site
298654010477	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
298654010478	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654010479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010480	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654010481	putative substrate translocation pore; other site
298654010482	tetracycline repressor protein TetR; Provisional; Region: PRK13756
298654010483	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010484	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654010485	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654010486	NAD binding site [chemical binding]; other site
298654010487	catalytic residues [active]
298654010488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654010489	S-adenosylmethionine binding site [chemical binding]; other site
298654010490	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654010491	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010492	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010493	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654010494	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654010495	putative ligand binding site [chemical binding]; other site
298654010496	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654010497	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654010498	HNH endonuclease; Region: HNH_2; pfam13391
298654010499	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298654010500	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654010501	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654010502	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654010503	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654010504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654010505	active site
298654010506	phosphorylation site [posttranslational modification]
298654010507	intermolecular recognition site; other site
298654010508	dimerization interface [polypeptide binding]; other site
298654010509	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654010510	DNA binding site [nucleotide binding]
298654010511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654010512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654010513	dimer interface [polypeptide binding]; other site
298654010514	phosphorylation site [posttranslational modification]
298654010515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654010516	ATP binding site [chemical binding]; other site
298654010517	Mg2+ binding site [ion binding]; other site
298654010518	G-X-G motif; other site
298654010519	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654010520	Cytochrome P450; Region: p450; cl12078
298654010521	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
298654010522	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
298654010523	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
298654010524	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654010525	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654010526	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654010527	Cytochrome P450; Region: p450; cl12078
298654010528	Phosphotransferase enzyme family; Region: APH; pfam01636
298654010529	Ecdysteroid kinase; Region: EcKinase; cl17738
298654010530	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654010531	active site 2 [active]
298654010532	active site 1 [active]
298654010533	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
298654010534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654010535	NAD(P) binding site [chemical binding]; other site
298654010536	active site
298654010537	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654010538	CoenzymeA binding site [chemical binding]; other site
298654010539	subunit interaction site [polypeptide binding]; other site
298654010540	PHB binding site; other site
298654010541	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654010542	active site 2 [active]
298654010543	active site 1 [active]
298654010544	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
298654010545	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
298654010546	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654010547	motif II; other site
298654010548	RibD C-terminal domain; Region: RibD_C; cl17279
298654010549	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654010550	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654010551	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654010552	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654010553	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654010554	putative DNA binding site [nucleotide binding]; other site
298654010555	putative Zn2+ binding site [ion binding]; other site
298654010556	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654010557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010558	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
298654010559	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
298654010560	malonyl-CoA binding site [chemical binding]; other site
298654010561	dimer interface [polypeptide binding]; other site
298654010562	active site
298654010563	product binding site; other site
298654010564	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
298654010565	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
298654010566	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
298654010567	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654010568	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010569	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010570	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654010571	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
298654010572	catalytic triad [active]
298654010573	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298654010574	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654010575	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654010576	Walker A motif; other site
298654010577	ATP binding site [chemical binding]; other site
298654010578	Walker B motif; other site
298654010579	arginine finger; other site
298654010580	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654010581	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654010582	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
298654010583	metal ion-dependent adhesion site (MIDAS); other site
298654010584	von Willebrand factor type A domain; Region: VWA_2; pfam13519
298654010585	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
298654010586	metal ion-dependent adhesion site (MIDAS); other site
298654010587	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
298654010588	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
298654010589	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654010590	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
298654010591	nucleotide binding site [chemical binding]; other site
298654010592	short chain dehydrogenase; Validated; Region: PRK08324
298654010593	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
298654010594	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654010595	NAD(P) binding site [chemical binding]; other site
298654010596	active site
298654010597	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
298654010598	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
298654010599	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
298654010600	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
298654010601	hexamer (dimer of trimers) interface [polypeptide binding]; other site
298654010602	trimer interface [polypeptide binding]; other site
298654010603	substrate binding site [chemical binding]; other site
298654010604	Mn binding site [ion binding]; other site
298654010605	Domain of unknown function (DUF718); Region: DUF718; pfam05336
298654010606	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654010607	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
298654010608	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654010609	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654010610	TM-ABC transporter signature motif; other site
298654010611	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654010612	TM-ABC transporter signature motif; other site
298654010613	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298654010614	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298654010615	Walker A/P-loop; other site
298654010616	ATP binding site [chemical binding]; other site
298654010617	Q-loop/lid; other site
298654010618	ABC transporter signature motif; other site
298654010619	Walker B; other site
298654010620	D-loop; other site
298654010621	H-loop/switch region; other site
298654010622	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298654010623	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654010624	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654010625	DNA binding site [nucleotide binding]
298654010626	domain linker motif; other site
298654010627	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
298654010628	dimerization interface [polypeptide binding]; other site
298654010629	ligand binding site [chemical binding]; other site
298654010630	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298654010631	Cysteine-rich domain; Region: CCG; pfam02754
298654010632	Cysteine-rich domain; Region: CCG; pfam02754
298654010633	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
298654010634	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
298654010635	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
298654010636	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
298654010637	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654010638	classical (c) SDRs; Region: SDR_c; cd05233
298654010639	NAD(P) binding site [chemical binding]; other site
298654010640	active site
298654010641	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654010642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654010643	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654010644	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654010645	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654010646	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654010647	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654010648	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654010649	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654010650	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654010651	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654010652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654010653	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654010654	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654010655	active site
298654010656	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
298654010657	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
298654010658	malonyl-CoA binding site [chemical binding]; other site
298654010659	dimer interface [polypeptide binding]; other site
298654010660	active site
298654010661	product binding site; other site
298654010662	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654010663	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654010664	Walker A/P-loop; other site
298654010665	ATP binding site [chemical binding]; other site
298654010666	Q-loop/lid; other site
298654010667	ABC transporter signature motif; other site
298654010668	Walker B; other site
298654010669	D-loop; other site
298654010670	H-loop/switch region; other site
298654010671	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654010672	Transcriptional regulator PadR-like family; Region: PadR; cl17335
298654010673	Uncharacterized conserved protein [Function unknown]; Region: COG1262
298654010674	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
298654010675	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
298654010676	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
298654010677	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
298654010678	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298654010679	catalytic residues [active]
298654010680	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
298654010681	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
298654010682	glycogen branching enzyme; Provisional; Region: PRK14705
298654010683	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
298654010684	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654010685	putative NAD(P) binding site [chemical binding]; other site
298654010686	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654010687	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010688	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654010689	Coenzyme A binding pocket [chemical binding]; other site
298654010690	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654010691	Coenzyme A binding pocket [chemical binding]; other site
298654010692	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654010693	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654010694	Walker A/P-loop; other site
298654010695	ATP binding site [chemical binding]; other site
298654010696	Q-loop/lid; other site
298654010697	ABC transporter signature motif; other site
298654010698	Walker B; other site
298654010699	D-loop; other site
298654010700	H-loop/switch region; other site
298654010701	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654010702	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654010703	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
298654010704	Uncharacterized conserved protein [Function unknown]; Region: COG4279
298654010705	SWIM zinc finger; Region: SWIM; pfam04434
298654010706	SNF2 Helicase protein; Region: DUF3670; pfam12419
298654010707	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
298654010708	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654010709	ATP binding site [chemical binding]; other site
298654010710	putative Mg++ binding site [ion binding]; other site
298654010711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654010712	nucleotide binding region [chemical binding]; other site
298654010713	ATP-binding site [chemical binding]; other site
298654010714	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654010715	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
298654010716	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654010717	Cytochrome P450; Region: p450; cl12078
298654010718	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654010719	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654010720	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654010721	Cytochrome P450; Region: p450; cl12078
298654010722	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010723	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010724	putative acyltransferase; Provisional; Region: PRK05790
298654010725	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654010726	dimer interface [polypeptide binding]; other site
298654010727	active site
298654010728	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654010729	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654010730	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654010731	lipid-transfer protein; Provisional; Region: PRK07855
298654010732	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654010733	active site
298654010734	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654010735	classical (c) SDRs; Region: SDR_c; cd05233
298654010736	NAD(P) binding site [chemical binding]; other site
298654010737	active site
298654010738	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654010739	classical (c) SDRs; Region: SDR_c; cd05233
298654010740	NAD(P) binding site [chemical binding]; other site
298654010741	active site
298654010742	Cupin domain; Region: Cupin_2; cl17218
298654010743	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654010744	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654010745	NAD(P) binding site [chemical binding]; other site
298654010746	active site
298654010747	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654010748	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
298654010749	iron-sulfur cluster [ion binding]; other site
298654010750	[2Fe-2S] cluster binding site [ion binding]; other site
298654010751	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654010752	hydrophobic ligand binding site; other site
298654010753	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654010754	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654010755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654010756	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298654010757	NAD(P) binding site [chemical binding]; other site
298654010758	active site
298654010759	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
298654010760	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
298654010761	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
298654010762	active site
298654010763	substrate binding site [chemical binding]; other site
298654010764	cosubstrate binding site; other site
298654010765	catalytic site [active]
298654010766	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654010767	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654010768	active site
298654010769	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298654010770	substrate binding site [chemical binding]; other site
298654010771	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654010772	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654010773	Coenzyme A binding pocket [chemical binding]; other site
298654010774	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654010775	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
298654010776	iron-sulfur cluster [ion binding]; other site
298654010777	[2Fe-2S] cluster binding site [ion binding]; other site
298654010778	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654010779	hydrophobic ligand binding site; other site
298654010780	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
298654010781	nucleoside/Zn binding site; other site
298654010782	dimer interface [polypeptide binding]; other site
298654010783	catalytic motif [active]
298654010784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654010785	S-adenosylmethionine binding site [chemical binding]; other site
298654010786	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
298654010787	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
298654010788	Probable Catalytic site; other site
298654010789	metal-binding site
298654010790	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
298654010791	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654010792	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654010793	Walker A/P-loop; other site
298654010794	ATP binding site [chemical binding]; other site
298654010795	Q-loop/lid; other site
298654010796	ABC transporter signature motif; other site
298654010797	Walker B; other site
298654010798	D-loop; other site
298654010799	H-loop/switch region; other site
298654010800	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654010801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654010802	Walker A/P-loop; other site
298654010803	ATP binding site [chemical binding]; other site
298654010804	Q-loop/lid; other site
298654010805	ABC transporter signature motif; other site
298654010806	Walker B; other site
298654010807	D-loop; other site
298654010808	H-loop/switch region; other site
298654010809	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298654010810	dimerization interface [polypeptide binding]; other site
298654010811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654010812	dimer interface [polypeptide binding]; other site
298654010813	phosphorylation site [posttranslational modification]
298654010814	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654010815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654010816	active site
298654010817	phosphorylation site [posttranslational modification]
298654010818	intermolecular recognition site; other site
298654010819	dimerization interface [polypeptide binding]; other site
298654010820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654010821	DNA binding site [nucleotide binding]
298654010822	Bacitracin resistance protein BacA; Region: BacA; pfam02673
298654010823	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298654010824	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
298654010825	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
298654010826	dimerization interface [polypeptide binding]; other site
298654010827	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654010828	dimer interface [polypeptide binding]; other site
298654010829	phosphorylation site [posttranslational modification]
298654010830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654010831	Mg2+ binding site [ion binding]; other site
298654010832	G-X-G motif; other site
298654010833	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654010834	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654010835	active site
298654010836	phosphorylation site [posttranslational modification]
298654010837	intermolecular recognition site; other site
298654010838	dimerization interface [polypeptide binding]; other site
298654010839	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654010840	DNA binding site [nucleotide binding]
298654010841	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
298654010842	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
298654010843	NAD(P) binding site [chemical binding]; other site
298654010844	catalytic residues [active]
298654010845	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654010846	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654010847	NAD binding site [chemical binding]; other site
298654010848	catalytic residues [active]
298654010849	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
298654010850	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
298654010851	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654010852	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654010853	putative ligand binding site [chemical binding]; other site
298654010854	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
298654010855	nucleophile elbow; other site
298654010856	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
298654010857	putative acyl-acceptor binding pocket; other site
298654010858	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654010859	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654010860	active site
298654010861	metal binding site [ion binding]; metal-binding site
298654010862	GAF domain; Region: GAF; cl17456
298654010863	GAF domain; Region: GAF_2; pfam13185
298654010864	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654010865	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654010866	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654010867	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654010868	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654010869	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654010870	acyl-activating enzyme (AAE) consensus motif; other site
298654010871	acyl-activating enzyme (AAE) consensus motif; other site
298654010872	active site
298654010873	AMP binding site [chemical binding]; other site
298654010874	CoA binding site [chemical binding]; other site
298654010875	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654010876	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
298654010877	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654010878	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654010879	substrate binding site [chemical binding]; other site
298654010880	oxyanion hole (OAH) forming residues; other site
298654010881	trimer interface [polypeptide binding]; other site
298654010882	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654010883	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654010884	active site
298654010885	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
298654010886	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298654010887	ATP binding site [chemical binding]; other site
298654010888	Mg++ binding site [ion binding]; other site
298654010889	motif III; other site
298654010890	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654010891	nucleotide binding region [chemical binding]; other site
298654010892	ATP-binding site [chemical binding]; other site
298654010893	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
298654010894	putative RNA binding site [nucleotide binding]; other site
298654010895	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654010896	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654010897	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
298654010898	putative hydrophobic ligand binding site [chemical binding]; other site
298654010899	MEKHLA domain; Region: MEKHLA; pfam08670
298654010900	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654010901	putative active site [active]
298654010902	heme pocket [chemical binding]; other site
298654010903	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
298654010904	metal binding site [ion binding]; metal-binding site
298654010905	TIR domain; Region: TIR_2; pfam13676
298654010906	TIR domain; Region: TIR_2; pfam13676
298654010907	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
298654010908	nudix motif; other site
298654010909	Methyltransferase domain; Region: Methyltransf_11; pfam08241
298654010910	S-adenosylmethionine binding site [chemical binding]; other site
298654010911	Uncharacterized conserved protein [Function unknown]; Region: COG3391
298654010912	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
298654010913	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
298654010914	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
298654010915	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
298654010916	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654010917	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654010918	putative DNA binding site [nucleotide binding]; other site
298654010919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
298654010920	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010921	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654010922	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654010923	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654010924	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654010925	dimerization interface [polypeptide binding]; other site
298654010926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654010927	dimer interface [polypeptide binding]; other site
298654010928	phosphorylation site [posttranslational modification]
298654010929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654010930	ATP binding site [chemical binding]; other site
298654010931	Mg2+ binding site [ion binding]; other site
298654010932	G-X-G motif; other site
298654010933	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654010934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654010935	active site
298654010936	phosphorylation site [posttranslational modification]
298654010937	intermolecular recognition site; other site
298654010938	dimerization interface [polypeptide binding]; other site
298654010939	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654010940	DNA binding site [nucleotide binding]
298654010941	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654010942	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298654010943	Walker A/P-loop; other site
298654010944	ATP binding site [chemical binding]; other site
298654010945	Q-loop/lid; other site
298654010946	ABC transporter signature motif; other site
298654010947	Walker B; other site
298654010948	D-loop; other site
298654010949	H-loop/switch region; other site
298654010950	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
298654010951	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
298654010952	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
298654010953	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654010954	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654010955	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654010956	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
298654010957	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
298654010958	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654010959	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654010960	metal binding site [ion binding]; metal-binding site
298654010961	active site
298654010962	I-site; other site
298654010963	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654010964	NB-ARC domain; Region: NB-ARC; pfam00931
298654010965	TIR domain; Region: TIR_2; pfam13676
298654010966	NB-ARC domain; Region: NB-ARC; pfam00931
298654010967	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654010968	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654010969	structural tetrad; other site
298654010970	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654010971	structural tetrad; other site
298654010972	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
298654010973	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654010974	structural tetrad; other site
298654010975	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654010976	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
298654010977	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
298654010978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010979	putative substrate translocation pore; other site
298654010980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654010981	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654010982	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654010983	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
298654010984	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
298654010985	Sulfate transporter family; Region: Sulfate_transp; pfam00916
298654010986	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
298654010987	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
298654010988	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654010989	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298654010990	Walker A/P-loop; other site
298654010991	ATP binding site [chemical binding]; other site
298654010992	Q-loop/lid; other site
298654010993	ABC transporter signature motif; other site
298654010994	Walker B; other site
298654010995	D-loop; other site
298654010996	H-loop/switch region; other site
298654010997	MarR family; Region: MarR_2; pfam12802
298654010998	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298654010999	Ligand Binding Site [chemical binding]; other site
298654011000	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298654011001	Ligand Binding Site [chemical binding]; other site
298654011002	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
298654011003	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
298654011004	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
298654011005	FAD binding pocket [chemical binding]; other site
298654011006	FAD binding motif [chemical binding]; other site
298654011007	phosphate binding motif [ion binding]; other site
298654011008	beta-alpha-beta structure motif; other site
298654011009	NAD binding pocket [chemical binding]; other site
298654011010	FMN-binding domain; Region: FMN_bind; cl01081
298654011011	ApbE family; Region: ApbE; pfam02424
298654011012	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654011013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654011014	active site
298654011015	phosphorylation site [posttranslational modification]
298654011016	intermolecular recognition site; other site
298654011017	dimerization interface [polypeptide binding]; other site
298654011018	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654011019	DNA binding site [nucleotide binding]
298654011020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654011021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654011022	dimerization interface [polypeptide binding]; other site
298654011023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654011024	dimer interface [polypeptide binding]; other site
298654011025	phosphorylation site [posttranslational modification]
298654011026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654011027	ATP binding site [chemical binding]; other site
298654011028	Mg2+ binding site [ion binding]; other site
298654011029	G-X-G motif; other site
298654011030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654011031	salt bridge; other site
298654011032	non-specific DNA binding site [nucleotide binding]; other site
298654011033	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654011034	sequence-specific DNA binding site [nucleotide binding]; other site
298654011035	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011036	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
298654011037	NAD(P) binding site [chemical binding]; other site
298654011038	active site
298654011039	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654011040	Fatty acid desaturase; Region: FA_desaturase; pfam00487
298654011041	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
298654011042	putative di-iron ligands [ion binding]; other site
298654011043	Uncharacterized conserved protein [Function unknown]; Region: COG2898
298654011044	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
298654011045	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298654011046	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298654011047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654011048	dimer interface [polypeptide binding]; other site
298654011049	conserved gate region; other site
298654011050	putative PBP binding loops; other site
298654011051	ABC-ATPase subunit interface; other site
298654011052	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654011053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654011054	dimer interface [polypeptide binding]; other site
298654011055	conserved gate region; other site
298654011056	putative PBP binding loops; other site
298654011057	ABC-ATPase subunit interface; other site
298654011058	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
298654011059	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
298654011060	Walker A/P-loop; other site
298654011061	ATP binding site [chemical binding]; other site
298654011062	Q-loop/lid; other site
298654011063	ABC transporter signature motif; other site
298654011064	Walker B; other site
298654011065	D-loop; other site
298654011066	H-loop/switch region; other site
298654011067	TOBE domain; Region: TOBE_2; pfam08402
298654011068	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
298654011069	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298654011070	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298654011071	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
298654011072	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
298654011073	tetramer interface [polypeptide binding]; other site
298654011074	active site
298654011075	Mg2+/Mn2+ binding site [ion binding]; other site
298654011076	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011077	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011078	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321
298654011079	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011080	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011081	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
298654011082	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
298654011083	molybdopterin cofactor binding site; other site
298654011084	Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568
298654011085	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654011086	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654011087	NAD(P) binding site [chemical binding]; other site
298654011088	catalytic residues [active]
298654011089	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
298654011090	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654011091	active site
298654011092	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654011093	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654011094	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011095	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011096	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654011097	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654011098	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654011099	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654011100	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654011101	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654011102	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654011103	putative active site [active]
298654011104	putative substrate binding site [chemical binding]; other site
298654011105	ATP binding site [chemical binding]; other site
298654011106	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011107	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011108	active site
298654011109	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654011110	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654011111	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654011112	classical (c) SDRs; Region: SDR_c; cd05233
298654011113	NAD(P) binding site [chemical binding]; other site
298654011114	active site
298654011115	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654011116	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654011117	classical (c) SDRs; Region: SDR_c; cd05233
298654011118	NAD(P) binding site [chemical binding]; other site
298654011119	active site
298654011120	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
298654011121	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654011122	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654011123	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654011124	NAD(P) binding site [chemical binding]; other site
298654011125	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
298654011126	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011127	acyl-activating enzyme (AAE) consensus motif; other site
298654011128	AMP binding site [chemical binding]; other site
298654011129	active site
298654011130	CoA binding site [chemical binding]; other site
298654011131	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
298654011132	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654011133	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654011134	Herpes virus protein UL24; Region: Herpes_UL24; cl17308
298654011135	Tannase and feruloyl esterase; Region: Tannase; pfam07519
298654011136	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
298654011137	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654011138	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011139	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011140	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011141	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654011142	putative ligand binding site [chemical binding]; other site
298654011143	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654011144	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654011145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654011146	active site
298654011147	phosphorylation site [posttranslational modification]
298654011148	intermolecular recognition site; other site
298654011149	dimerization interface [polypeptide binding]; other site
298654011150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654011151	DNA binding site [nucleotide binding]
298654011152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654011153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654011154	dimerization interface [polypeptide binding]; other site
298654011155	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654011156	dimer interface [polypeptide binding]; other site
298654011157	phosphorylation site [posttranslational modification]
298654011158	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654011159	ATP binding site [chemical binding]; other site
298654011160	Mg2+ binding site [ion binding]; other site
298654011161	G-X-G motif; other site
298654011162	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654011163	catalytic triad [active]
298654011164	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011165	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011167	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654011168	NAD(P) binding site [chemical binding]; other site
298654011169	active site
298654011170	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
298654011171	dimer interface [polypeptide binding]; other site
298654011172	substrate binding site [chemical binding]; other site
298654011173	metal binding site [ion binding]; metal-binding site
298654011174	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654011175	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654011176	non-specific DNA binding site [nucleotide binding]; other site
298654011177	salt bridge; other site
298654011178	sequence-specific DNA binding site [nucleotide binding]; other site
298654011179	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
298654011180	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654011181	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654011182	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654011183	3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370
298654011184	active site
298654011185	metal binding site [ion binding]; metal-binding site
298654011186	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654011187	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654011188	NAD(P) binding site [chemical binding]; other site
298654011189	Predicted acyl esterases [General function prediction only]; Region: COG2936
298654011190	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654011191	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654011192	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
298654011193	iron-sulfur cluster [ion binding]; other site
298654011194	[2Fe-2S] cluster binding site [ion binding]; other site
298654011195	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
298654011196	beta subunit interface [polypeptide binding]; other site
298654011197	alpha subunit interface [polypeptide binding]; other site
298654011198	active site
298654011199	substrate binding site [chemical binding]; other site
298654011200	Fe binding site [ion binding]; other site
298654011201	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
298654011202	[2Fe-2S] cluster binding site [ion binding]; other site
298654011203	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
298654011204	inter-subunit interface; other site
298654011205	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
298654011206	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
298654011207	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
298654011208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011209	NAD(P) binding site [chemical binding]; other site
298654011210	active site
298654011211	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
298654011212	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011213	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654011214	acyl-activating enzyme (AAE) consensus motif; other site
298654011215	acyl-activating enzyme (AAE) consensus motif; other site
298654011216	putative AMP binding site [chemical binding]; other site
298654011217	putative active site [active]
298654011218	putative CoA binding site [chemical binding]; other site
298654011219	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011220	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011221	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011223	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
298654011224	acetaldehyde dehydrogenase; Validated; Region: PRK08300
298654011225	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298654011226	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
298654011227	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
298654011228	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
298654011229	active site
298654011230	catalytic residues [active]
298654011231	metal binding site [ion binding]; metal-binding site
298654011232	DmpG-like communication domain; Region: DmpG_comm; pfam07836
298654011233	Predicted acyl esterases [General function prediction only]; Region: COG2936
298654011234	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654011235	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654011236	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654011237	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011238	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654011239	acyl-activating enzyme (AAE) consensus motif; other site
298654011240	acyl-activating enzyme (AAE) consensus motif; other site
298654011241	putative AMP binding site [chemical binding]; other site
298654011242	putative active site [active]
298654011243	putative CoA binding site [chemical binding]; other site
298654011244	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011245	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011246	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654011247	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654011248	metal binding site [ion binding]; metal-binding site
298654011249	active site
298654011250	I-site; other site
298654011251	Predicted acyl esterases [General function prediction only]; Region: COG2936
298654011252	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654011253	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
298654011254	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654011255	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
298654011256	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011257	NAD(P) binding site [chemical binding]; other site
298654011258	active site
298654011259	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011260	substrate binding site [chemical binding]; other site
298654011261	oxyanion hole (OAH) forming residues; other site
298654011262	trimer interface [polypeptide binding]; other site
298654011263	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
298654011264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011265	acyl-activating enzyme (AAE) consensus motif; other site
298654011266	AMP binding site [chemical binding]; other site
298654011267	active site
298654011268	CoA binding site [chemical binding]; other site
298654011269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011271	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011272	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011274	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011275	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654011276	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298654011277	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654011278	phosphate binding site [ion binding]; other site
298654011279	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
298654011280	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011281	acyl-activating enzyme (AAE) consensus motif; other site
298654011282	AMP binding site [chemical binding]; other site
298654011283	active site
298654011284	CoA binding site [chemical binding]; other site
298654011285	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011286	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011287	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654011288	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654011289	Cytochrome P450; Region: p450; cl12078
298654011290	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654011291	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
298654011292	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654011293	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654011294	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654011295	NAD binding site [chemical binding]; other site
298654011296	catalytic residues [active]
298654011297	lipid-transfer protein; Provisional; Region: PRK07855
298654011298	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654011299	active site
298654011300	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654011301	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654011302	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654011303	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654011304	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011305	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011306	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654011307	TM-ABC transporter signature motif; other site
298654011308	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654011309	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654011310	TM-ABC transporter signature motif; other site
298654011311	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654011312	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654011313	Walker A/P-loop; other site
298654011314	ATP binding site [chemical binding]; other site
298654011315	Q-loop/lid; other site
298654011316	ABC transporter signature motif; other site
298654011317	Walker B; other site
298654011318	D-loop; other site
298654011319	H-loop/switch region; other site
298654011320	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654011321	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654011322	Walker A/P-loop; other site
298654011323	ATP binding site [chemical binding]; other site
298654011324	Q-loop/lid; other site
298654011325	ABC transporter signature motif; other site
298654011326	Walker B; other site
298654011327	D-loop; other site
298654011328	H-loop/switch region; other site
298654011329	Ecdysteroid kinase; Region: EcKinase; cl17738
298654011330	Phosphotransferase enzyme family; Region: APH; pfam01636
298654011331	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
298654011332	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654011333	classical (c) SDRs; Region: SDR_c; cd05233
298654011334	NAD(P) binding site [chemical binding]; other site
298654011335	active site
298654011336	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654011337	Cytochrome P450; Region: p450; cl12078
298654011338	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654011339	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654011340	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654011341	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654011342	DNA-binding site [nucleotide binding]; DNA binding site
298654011343	FCD domain; Region: FCD; pfam07729
298654011344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654011345	S-adenosylmethionine binding site [chemical binding]; other site
298654011346	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
298654011347	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654011348	active site
298654011349	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654011350	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654011351	dimer interface [polypeptide binding]; other site
298654011352	phosphorylation site [posttranslational modification]
298654011353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654011354	ATP binding site [chemical binding]; other site
298654011355	Mg2+ binding site [ion binding]; other site
298654011356	G-X-G motif; other site
298654011357	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654011358	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011359	NAD(P) binding site [chemical binding]; other site
298654011360	active site
298654011361	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654011362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654011363	active site
298654011364	phosphorylation site [posttranslational modification]
298654011365	intermolecular recognition site; other site
298654011366	dimerization interface [polypeptide binding]; other site
298654011367	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654011368	DNA binding site [nucleotide binding]
298654011369	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
298654011370	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
298654011371	Moco binding site; other site
298654011372	metal coordination site [ion binding]; other site
298654011373	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654011374	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
298654011375	NmrA-like family; Region: NmrA; pfam05368
298654011376	NADP binding site [chemical binding]; other site
298654011377	active site
298654011378	regulatory binding site [polypeptide binding]; other site
298654011379	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011380	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011381	Phosphotransferase enzyme family; Region: APH; pfam01636
298654011382	Ecdysteroid kinase; Region: EcKinase; cl17738
298654011383	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
298654011384	heme-binding site [chemical binding]; other site
298654011385	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654011386	structural tetrad; other site
298654011387	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654011388	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654011389	structural tetrad; other site
298654011390	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654011391	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654011392	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011393	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654011395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654011396	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298654011397	dimerization interface [polypeptide binding]; other site
298654011398	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
298654011399	active site
298654011400	catalytic triad [active]
298654011401	oxyanion hole [active]
298654011402	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011403	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011404	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654011405	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654011406	NAD(P) binding site [chemical binding]; other site
298654011407	catalytic residues [active]
298654011408	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654011409	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654011410	Cytochrome P450; Region: p450; cl12078
298654011411	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654011412	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654011413	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654011414	active site
298654011415	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011416	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011417	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654011418	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654011419	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654011420	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654011421	NAD(P) binding site [chemical binding]; other site
298654011422	catalytic residues [active]
298654011423	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654011424	classical (c) SDRs; Region: SDR_c; cd05233
298654011425	NAD(P) binding site [chemical binding]; other site
298654011426	active site
298654011427	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011428	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011429	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011430	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011431	active site
298654011432	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654011433	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654011434	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654011435	lipid-transfer protein; Provisional; Region: PRK07855
298654011436	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654011437	active site
298654011438	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011439	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011440	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011441	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654011442	putative ligand binding site [chemical binding]; other site
298654011443	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011444	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011445	active site
298654011446	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654011447	classical (c) SDRs; Region: SDR_c; cd05233
298654011448	NAD(P) binding site [chemical binding]; other site
298654011449	active site
298654011450	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654011451	active site
298654011452	enoyl-CoA hydratase; Provisional; Region: PRK08260
298654011453	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011454	substrate binding site [chemical binding]; other site
298654011455	oxyanion hole (OAH) forming residues; other site
298654011456	trimer interface [polypeptide binding]; other site
298654011457	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654011458	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011459	substrate binding site [chemical binding]; other site
298654011460	oxyanion hole (OAH) forming residues; other site
298654011461	trimer interface [polypeptide binding]; other site
298654011462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011464	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011465	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011466	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654011467	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011468	substrate binding site [chemical binding]; other site
298654011469	oxyanion hole (OAH) forming residues; other site
298654011470	trimer interface [polypeptide binding]; other site
298654011471	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
298654011472	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654011473	dimer interface [polypeptide binding]; other site
298654011474	active site
298654011475	short chain dehydrogenase; Provisional; Region: PRK06197
298654011476	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
298654011477	putative NAD(P) binding site [chemical binding]; other site
298654011478	active site
298654011479	enoyl-CoA hydratase; Provisional; Region: PRK08260
298654011480	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011481	substrate binding site [chemical binding]; other site
298654011482	oxyanion hole (OAH) forming residues; other site
298654011483	trimer interface [polypeptide binding]; other site
298654011484	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654011485	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654011486	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
298654011487	Strictosidine synthase; Region: Str_synth; pfam03088
298654011488	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011489	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654011490	ligand binding site [chemical binding]; other site
298654011491	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654011492	Cytochrome P450; Region: p450; cl12078
298654011493	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011494	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654011495	putative ligand binding site [chemical binding]; other site
298654011496	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654011497	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654011498	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654011499	SnoaL-like domain; Region: SnoaL_3; pfam13474
298654011500	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298654011501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011502	NAD(P) binding site [chemical binding]; other site
298654011503	active site
298654011504	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011505	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011506	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654011507	Carboxylesterase family; Region: COesterase; pfam00135
298654011508	substrate binding pocket [chemical binding]; other site
298654011509	catalytic triad [active]
298654011510	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011511	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011512	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
298654011513	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654011514	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654011515	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
298654011516	putative dimerization interface [polypeptide binding]; other site
298654011517	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
298654011518	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
298654011519	CrcB-like protein; Region: CRCB; pfam02537
298654011520	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
298654011521	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654011522	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654011523	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
298654011524	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
298654011525	active site
298654011526	dimer interface [polypeptide binding]; other site
298654011527	non-prolyl cis peptide bond; other site
298654011528	insertion regions; other site
298654011529	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654011530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654011531	putative PBP binding loops; other site
298654011532	dimer interface [polypeptide binding]; other site
298654011533	ABC-ATPase subunit interface; other site
298654011534	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654011535	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654011536	Walker A/P-loop; other site
298654011537	ATP binding site [chemical binding]; other site
298654011538	Q-loop/lid; other site
298654011539	ABC transporter signature motif; other site
298654011540	Walker B; other site
298654011541	D-loop; other site
298654011542	H-loop/switch region; other site
298654011543	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
298654011544	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
298654011545	membrane-bound complex binding site; other site
298654011546	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654011547	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
298654011548	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654011549	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011550	acyl-activating enzyme (AAE) consensus motif; other site
298654011551	AMP binding site [chemical binding]; other site
298654011552	active site
298654011553	CoA binding site [chemical binding]; other site
298654011554	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
298654011555	FMN binding site [chemical binding]; other site
298654011556	substrate binding site [chemical binding]; other site
298654011557	putative catalytic residue [active]
298654011558	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
298654011559	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
298654011560	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298654011561	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011562	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011563	Domain of unknown function (DUF385); Region: DUF385; cl04387
298654011564	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
298654011565	conserved cys residue [active]
298654011566	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298654011567	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654011568	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654011569	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
298654011570	DNA binding site [nucleotide binding]
298654011571	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654011572	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
298654011573	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
298654011574	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654011575	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
298654011576	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654011577	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654011578	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
298654011579	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298654011580	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
298654011581	hydrophobic ligand binding site; other site
298654011582	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
298654011583	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011584	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011585	Erythronolide synthase docking; Region: Docking; pfam08990
298654011586	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011587	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011588	active site
298654011589	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011590	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011591	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011592	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011593	putative NADP binding site [chemical binding]; other site
298654011594	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011595	active site
298654011596	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011597	Erythronolide synthase docking; Region: Docking; pfam08990
298654011598	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654011599	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011600	active site
298654011601	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011602	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011603	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011604	putative NADP binding site [chemical binding]; other site
298654011605	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011606	active site
298654011607	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011608	Erythronolide synthase docking; Region: Docking; pfam08990
298654011609	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011610	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011611	active site
298654011612	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011613	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011614	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011615	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011616	putative NADP binding site [chemical binding]; other site
298654011617	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011618	active site
298654011619	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011620	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011621	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011622	active site
298654011623	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011624	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011625	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011626	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
298654011627	Acid Phosphatase; Region: Acid_PPase; cl17256
298654011628	Phosphopantetheine attachment site; Region: PP-binding; cl09936
298654011629	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298654011630	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654011631	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011632	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011633	active site
298654011634	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011635	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011636	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011637	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654011638	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011639	active site
298654011640	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011641	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011642	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011643	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
298654011644	Enoylreductase; Region: PKS_ER; smart00829
298654011645	NAD(P) binding site [chemical binding]; other site
298654011646	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011647	putative NADP binding site [chemical binding]; other site
298654011648	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011649	active site
298654011650	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011651	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011652	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011653	active site
298654011654	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011655	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011656	ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952
298654011657	NADP binding site [chemical binding]; other site
298654011658	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011659	active site
298654011660	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011661	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011662	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011663	active site
298654011664	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011665	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011666	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011667	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011668	putative NADP binding site [chemical binding]; other site
298654011669	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011670	active site
298654011671	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011672	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011673	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298654011674	active site
298654011675	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298654011676	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011677	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011678	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011679	putative NADP binding site [chemical binding]; other site
298654011680	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011681	active site
298654011682	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011683	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654011684	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011685	active site
298654011686	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011687	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011689	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
298654011690	Enoylreductase; Region: PKS_ER; smart00829
298654011691	NAD(P) binding site [chemical binding]; other site
298654011692	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011693	putative NADP binding site [chemical binding]; other site
298654011694	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011695	active site
298654011696	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011697	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654011698	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011699	active site
298654011700	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011701	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011702	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011703	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011704	putative NADP binding site [chemical binding]; other site
298654011705	active site
298654011706	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011707	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654011708	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654011709	active site
298654011710	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654011711	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654011712	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
298654011713	putative NADP binding site [chemical binding]; other site
298654011714	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298654011715	active site
298654011716	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654011717	hypothetical protein; Provisional; Region: PRK06834
298654011718	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654011719	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
298654011720	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
298654011721	active site
298654011722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654011723	S-adenosylmethionine binding site [chemical binding]; other site
298654011724	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654011725	Cytochrome P450; Region: p450; cl12078
298654011726	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654011727	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654011728	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
298654011729	Walker A/P-loop; other site
298654011730	ATP binding site [chemical binding]; other site
298654011731	Q-loop/lid; other site
298654011732	ABC transporter signature motif; other site
298654011733	Walker B; other site
298654011734	D-loop; other site
298654011735	H-loop/switch region; other site
298654011736	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
298654011737	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
298654011738	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
298654011739	DNA binding site [nucleotide binding]
298654011740	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654011741	Acyl transferase domain; Region: Acyl_transf_1; cl08282
298654011742	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654011743	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654011744	DNA binding residues [nucleotide binding]
298654011745	dimerization interface [polypeptide binding]; other site
298654011746	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011747	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654011748	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011749	substrate binding site [chemical binding]; other site
298654011750	oxyanion hole (OAH) forming residues; other site
298654011751	trimer interface [polypeptide binding]; other site
298654011752	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654011753	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011754	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011755	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011756	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011757	active site
298654011758	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654011759	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654011760	[2Fe-2S] cluster binding site [ion binding]; other site
298654011761	enoyl-CoA hydratase; Provisional; Region: PRK06210
298654011762	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011763	substrate binding site [chemical binding]; other site
298654011764	oxyanion hole (OAH) forming residues; other site
298654011765	trimer interface [polypeptide binding]; other site
298654011766	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
298654011767	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654011768	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654011769	short chain dehydrogenase; Provisional; Region: PRK06940
298654011770	NAD(P) binding site [chemical binding]; other site
298654011771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011772	active site
298654011773	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011774	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654011775	MarR family; Region: MarR_2; pfam12802
298654011776	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298654011777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654011778	Coenzyme A binding pocket [chemical binding]; other site
298654011779	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
298654011780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654011781	Walker A motif; other site
298654011782	ATP binding site [chemical binding]; other site
298654011783	Walker B motif; other site
298654011784	arginine finger; other site
298654011785	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654011786	TPR motif; other site
298654011787	binding surface
298654011788	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654011789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654011790	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
298654011791	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654011792	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654011793	active site
298654011794	metal binding site [ion binding]; metal-binding site
298654011795	GAF domain; Region: GAF; cl17456
298654011796	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654011797	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654011798	DNA binding residues [nucleotide binding]
298654011799	dimerization interface [polypeptide binding]; other site
298654011800	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654011801	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654011802	active site
298654011803	ATP binding site [chemical binding]; other site
298654011804	substrate binding site [chemical binding]; other site
298654011805	activation loop (A-loop); other site
298654011806	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654011807	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654011808	structural tetrad; other site
298654011809	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654011810	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
298654011811	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654011812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654011813	active site
298654011814	phosphorylation site [posttranslational modification]
298654011815	intermolecular recognition site; other site
298654011816	dimerization interface [polypeptide binding]; other site
298654011817	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654011818	DNA binding residues [nucleotide binding]
298654011819	dimerization interface [polypeptide binding]; other site
298654011820	Histidine kinase; Region: HisKA_3; pfam07730
298654011821	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654011822	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654011823	metal binding site [ion binding]; metal-binding site
298654011824	active site
298654011825	I-site; other site
298654011826	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654011827	PAS domain; Region: PAS_9; pfam13426
298654011828	PAS domain S-box; Region: sensory_box; TIGR00229
298654011829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654011830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654011831	metal binding site [ion binding]; metal-binding site
298654011832	active site
298654011833	I-site; other site
298654011834	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654011835	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011836	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011837	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
298654011838	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654011839	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654011840	active site
298654011841	metal binding site [ion binding]; metal-binding site
298654011842	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011843	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654011844	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298654011845	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
298654011846	Walker A/P-loop; other site
298654011847	ATP binding site [chemical binding]; other site
298654011848	Q-loop/lid; other site
298654011849	ABC transporter signature motif; other site
298654011850	Walker B; other site
298654011851	D-loop; other site
298654011852	H-loop/switch region; other site
298654011853	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298654011854	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298654011855	substrate binding pocket [chemical binding]; other site
298654011856	membrane-bound complex binding site; other site
298654011857	hinge residues; other site
298654011858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654011859	dimer interface [polypeptide binding]; other site
298654011860	conserved gate region; other site
298654011861	putative PBP binding loops; other site
298654011862	ABC-ATPase subunit interface; other site
298654011863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654011864	dimer interface [polypeptide binding]; other site
298654011865	conserved gate region; other site
298654011866	putative PBP binding loops; other site
298654011867	ABC-ATPase subunit interface; other site
298654011868	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011869	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654011870	active site
298654011871	Leishmanolysin; Region: Peptidase_M8; pfam01457
298654011872	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011873	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011874	active site
298654011875	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654011876	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011877	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
298654011878	acyl-activating enzyme (AAE) consensus motif; other site
298654011879	acyl-activating enzyme (AAE) consensus motif; other site
298654011880	putative AMP binding site [chemical binding]; other site
298654011881	putative active site [active]
298654011882	putative CoA binding site [chemical binding]; other site
298654011883	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
298654011884	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654011885	Cytochrome P450; Region: p450; cl12078
298654011886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011887	short chain dehydrogenase; Provisional; Region: PRK12827
298654011888	NAD(P) binding site [chemical binding]; other site
298654011889	active site
298654011890	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654011891	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654011892	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654011893	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
298654011894	FAD binding site [chemical binding]; other site
298654011895	substrate binding site [chemical binding]; other site
298654011896	catalytic base [active]
298654011897	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654011898	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654011899	AMP binding site [chemical binding]; other site
298654011900	active site
298654011901	acyl-activating enzyme (AAE) consensus motif; other site
298654011902	CoA binding site [chemical binding]; other site
298654011903	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011904	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
298654011905	substrate binding site [chemical binding]; other site
298654011906	oxyanion hole (OAH) forming residues; other site
298654011907	trimer interface [polypeptide binding]; other site
298654011908	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654011909	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654011910	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654011911	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654011912	substrate binding site [chemical binding]; other site
298654011913	oxyanion hole (OAH) forming residues; other site
298654011914	trimer interface [polypeptide binding]; other site
298654011915	Selenium binding protein; Region: SeleniumBinding; cl13040
298654011916	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
298654011917	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654011918	active site 2 [active]
298654011919	active site 1 [active]
298654011920	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654011921	active site 1 [active]
298654011922	active site 2 [active]
298654011923	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654011924	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654011925	NAD binding site [chemical binding]; other site
298654011926	catalytic residues [active]
298654011927	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654011928	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
298654011929	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654011930	active site
298654011931	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
298654011932	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
298654011933	acyl-activating enzyme (AAE) consensus motif; other site
298654011934	putative AMP binding site [chemical binding]; other site
298654011935	putative active site [active]
298654011936	putative CoA binding site [chemical binding]; other site
298654011937	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011938	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654011939	ligand binding site [chemical binding]; other site
298654011940	probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857
298654011941	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298654011942	active site
298654011943	substrate binding site [chemical binding]; other site
298654011944	ATP binding site [chemical binding]; other site
298654011945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654011946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654011947	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011948	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298654011949	NAD(P) binding site [chemical binding]; other site
298654011950	active site
298654011951	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654011952	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654011953	NAD binding site [chemical binding]; other site
298654011954	catalytic residues [active]
298654011955	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654011956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011957	NAD(P) binding site [chemical binding]; other site
298654011958	active site
298654011959	Ecdysteroid kinase; Region: EcKinase; cl17738
298654011960	Phosphotransferase enzyme family; Region: APH; pfam01636
298654011961	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654011962	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654011963	DNA-binding site [nucleotide binding]; DNA binding site
298654011964	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298654011965	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298654011966	MMPL family; Region: MMPL; pfam03176
298654011967	Histidine kinase; Region: HisKA_3; pfam07730
298654011968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654011969	ATP binding site [chemical binding]; other site
298654011970	Mg2+ binding site [ion binding]; other site
298654011971	G-X-G motif; other site
298654011972	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654011973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654011974	active site
298654011975	phosphorylation site [posttranslational modification]
298654011976	intermolecular recognition site; other site
298654011977	dimerization interface [polypeptide binding]; other site
298654011978	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654011979	DNA binding residues [nucleotide binding]
298654011980	dimerization interface [polypeptide binding]; other site
298654011981	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011982	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654011983	putative ligand binding site [chemical binding]; other site
298654011984	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
298654011985	signature motif; other site
298654011986	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298654011987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654011988	NAD(P) binding site [chemical binding]; other site
298654011989	active site
298654011990	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654011991	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654011992	putative ligand binding site [chemical binding]; other site
298654011993	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654011994	MarR family; Region: MarR_2; pfam12802
298654011995	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
298654011996	ThiC-associated domain; Region: ThiC-associated; pfam13667
298654011997	ThiC family; Region: ThiC; pfam01964
298654011998	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
298654011999	active site
298654012000	dimer interface [polypeptide binding]; other site
298654012001	motif 1; other site
298654012002	motif 2; other site
298654012003	motif 3; other site
298654012004	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
298654012005	anticodon binding site; other site
298654012006	TIR domain; Region: TIR_2; pfam13676
298654012007	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
298654012008	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
298654012009	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654012010	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654012011	structural tetrad; other site
298654012012	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654012013	structural tetrad; other site
298654012014	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
298654012015	RibD C-terminal domain; Region: RibD_C; cl17279
298654012016	RNA polymerase factor sigma-70; Validated; Region: PRK08241
298654012017	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654012018	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654012019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012020	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654012021	putative substrate translocation pore; other site
298654012022	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654012023	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012024	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654012025	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
298654012026	dimer interface [polypeptide binding]; other site
298654012027	decamer (pentamer of dimers) interface [polypeptide binding]; other site
298654012028	catalytic triad [active]
298654012029	peroxidatic and resolving cysteines [active]
298654012030	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
298654012031	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654012032	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654012033	TIGR03086 family protein; Region: TIGR03086
298654012034	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012035	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012036	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654012037	MarR family; Region: MarR_2; cl17246
298654012038	short chain dehydrogenase; Provisional; Region: PRK06523
298654012039	classical (c) SDRs; Region: SDR_c; cd05233
298654012040	NAD(P) binding site [chemical binding]; other site
298654012041	active site
298654012042	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
298654012043	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
298654012044	putative NAD(P) binding site [chemical binding]; other site
298654012045	putative substrate binding site [chemical binding]; other site
298654012046	catalytic Zn binding site [ion binding]; other site
298654012047	structural Zn binding site [ion binding]; other site
298654012048	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654012049	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654012050	substrate binding site [chemical binding]; other site
298654012051	oxyanion hole (OAH) forming residues; other site
298654012052	trimer interface [polypeptide binding]; other site
298654012053	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012055	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
298654012056	putative hydrophobic ligand binding site [chemical binding]; other site
298654012057	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012059	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654012060	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012061	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012063	NAD(P) binding site [chemical binding]; other site
298654012064	active site
298654012065	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654012066	Cytochrome P450; Region: p450; cl12078
298654012067	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654012068	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654012069	NAD binding site [chemical binding]; other site
298654012070	catalytic residues [active]
298654012071	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012072	classical (c) SDRs; Region: SDR_c; cd05233
298654012073	NAD(P) binding site [chemical binding]; other site
298654012074	active site
298654012075	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298654012076	pantoate--beta-alanine ligase; Region: panC; TIGR00018
298654012077	active site
298654012078	nucleotide binding site [chemical binding]; other site
298654012079	HIGH motif; other site
298654012080	KMSKS motif; other site
298654012081	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654012082	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654012083	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012084	FtsX-like permease family; Region: FtsX; pfam02687
298654012085	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654012086	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654012087	Walker A/P-loop; other site
298654012088	ATP binding site [chemical binding]; other site
298654012089	Q-loop/lid; other site
298654012090	ABC transporter signature motif; other site
298654012091	Walker B; other site
298654012092	D-loop; other site
298654012093	H-loop/switch region; other site
298654012094	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
298654012095	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654012096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654012097	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298654012098	dimerization interface [polypeptide binding]; other site
298654012099	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
298654012100	active site
298654012101	catalytic site [active]
298654012102	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
298654012103	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654012104	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
298654012105	acyl-CoA synthetase; Validated; Region: PRK05850
298654012106	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
298654012107	acyl-activating enzyme (AAE) consensus motif; other site
298654012108	active site
298654012109	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654012110	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
298654012111	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298654012112	active site
298654012113	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298654012114	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298654012115	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012116	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
298654012117	putative NADP binding site [chemical binding]; other site
298654012118	KR domain; Region: KR; pfam08659
298654012119	active site
298654012120	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
298654012121	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
298654012122	Putative esterase; Region: Esterase; pfam00756
298654012123	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654012124	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
298654012125	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
298654012126	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
298654012127	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012128	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654012129	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654012130	DNA binding residues [nucleotide binding]
298654012131	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654012132	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012133	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012134	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
298654012135	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
298654012136	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654012137	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654012138	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012139	NAD(P) binding site [chemical binding]; other site
298654012140	active site
298654012141	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
298654012142	active site
298654012143	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
298654012144	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
298654012145	CysD dimerization site [polypeptide binding]; other site
298654012146	G1 box; other site
298654012147	putative GEF interaction site [polypeptide binding]; other site
298654012148	GTP/Mg2+ binding site [chemical binding]; other site
298654012149	Switch I region; other site
298654012150	G2 box; other site
298654012151	G3 box; other site
298654012152	Switch II region; other site
298654012153	G4 box; other site
298654012154	G5 box; other site
298654012155	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
298654012156	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
298654012157	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
298654012158	ligand-binding site [chemical binding]; other site
298654012159	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
298654012160	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298654012161	Active Sites [active]
298654012162	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654012163	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654012164	NAD(P) binding site [chemical binding]; other site
298654012165	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298654012166	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654012167	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654012168	classical (c) SDRs; Region: SDR_c; cd05233
298654012169	NAD(P) binding site [chemical binding]; other site
298654012170	active site
298654012171	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654012172	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654012173	Bacterial transcriptional regulator; Region: IclR; pfam01614
298654012174	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
298654012175	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654012176	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654012177	dimerization interface [polypeptide binding]; other site
298654012178	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654012179	dimer interface [polypeptide binding]; other site
298654012180	phosphorylation site [posttranslational modification]
298654012181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654012182	ATP binding site [chemical binding]; other site
298654012183	Mg2+ binding site [ion binding]; other site
298654012184	G-X-G motif; other site
298654012185	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654012186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654012187	active site
298654012188	phosphorylation site [posttranslational modification]
298654012189	intermolecular recognition site; other site
298654012190	dimerization interface [polypeptide binding]; other site
298654012191	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654012192	DNA binding site [nucleotide binding]
298654012193	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654012194	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654012195	active site
298654012196	catalytic tetrad [active]
298654012197	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012198	classical (c) SDRs; Region: SDR_c; cd05233
298654012199	NAD(P) binding site [chemical binding]; other site
298654012200	active site
298654012201	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654012202	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012203	NAD(P) binding site [chemical binding]; other site
298654012204	active site
298654012205	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
298654012206	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654012207	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
298654012208	putative dimerization interface [polypeptide binding]; other site
298654012209	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
298654012210	Low molecular weight phosphatase family; Region: LMWPc; cl00105
298654012211	active site
298654012212	Chromate transporter; Region: Chromate_transp; pfam02417
298654012213	Chromate transporter; Region: Chromate_transp; pfam02417
298654012214	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
298654012215	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654012216	classical (c) SDRs; Region: SDR_c; cd05233
298654012217	NAD(P) binding site [chemical binding]; other site
298654012218	active site
298654012219	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654012220	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654012221	DNA-binding site [nucleotide binding]; DNA binding site
298654012222	FCD domain; Region: FCD; pfam07729
298654012223	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654012224	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654012225	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012226	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012227	NAD(P) binding site [chemical binding]; other site
298654012228	active site
298654012229	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654012230	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654012231	active site
298654012232	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
298654012233	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298654012234	PYR/PP interface [polypeptide binding]; other site
298654012235	dimer interface [polypeptide binding]; other site
298654012236	TPP binding site [chemical binding]; other site
298654012237	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298654012238	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
298654012239	TPP-binding site; other site
298654012240	dimer interface [polypeptide binding]; other site
298654012241	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654012242	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654012243	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
298654012244	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
298654012245	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
298654012246	active site
298654012247	FMN binding site [chemical binding]; other site
298654012248	substrate binding site [chemical binding]; other site
298654012249	putative catalytic residue [active]
298654012250	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654012251	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654012252	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
298654012253	active site
298654012254	catalytic residues [active]
298654012255	metal binding site [ion binding]; metal-binding site
298654012256	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
298654012257	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012258	classical (c) SDRs; Region: SDR_c; cd05233
298654012259	NAD(P) binding site [chemical binding]; other site
298654012260	active site
298654012261	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654012262	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654012263	[2Fe-2S] cluster binding site [ion binding]; other site
298654012264	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654012265	hydrophobic ligand binding site; other site
298654012266	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
298654012267	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654012268	NAD binding site [chemical binding]; other site
298654012269	catalytic residues [active]
298654012270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012271	NAD(P) binding site [chemical binding]; other site
298654012272	active site
298654012273	Ecdysteroid kinase; Region: EcKinase; cl17738
298654012274	Ecdysteroid kinase; Region: EcKinase; cl17738
298654012275	TIR domain; Region: TIR_2; pfam13676
298654012276	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012277	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012278	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012279	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012280	Tetratricopeptide repeat; Region: TPR_10; cl17452
298654012281	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654012282	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654012283	Domain of unknown function (DUF385); Region: DUF385; pfam04075
298654012284	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654012285	Cytochrome P450; Region: p450; cl12078
298654012286	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012287	classical (c) SDRs; Region: SDR_c; cd05233
298654012288	NAD(P) binding site [chemical binding]; other site
298654012289	active site
298654012290	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654012291	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654012292	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654012293	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654012294	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654012295	NAD binding site [chemical binding]; other site
298654012296	catalytic residues [active]
298654012297	thiolase; Provisional; Region: PRK06158
298654012298	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654012299	active site
298654012300	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654012301	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654012302	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654012303	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654012304	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654012305	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654012306	acyl-activating enzyme (AAE) consensus motif; other site
298654012307	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654012308	putative AMP binding site [chemical binding]; other site
298654012309	putative active site [active]
298654012310	acyl-activating enzyme (AAE) consensus motif; other site
298654012311	putative CoA binding site [chemical binding]; other site
298654012312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012314	Ecdysteroid kinase; Region: EcKinase; cl17738
298654012315	Phosphotransferase enzyme family; Region: APH; pfam01636
298654012316	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012317	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012319	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654012320	putative substrate translocation pore; other site
298654012321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012322	putative substrate translocation pore; other site
298654012323	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654012324	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654012325	active site
298654012326	ATP binding site [chemical binding]; other site
298654012327	substrate binding site [chemical binding]; other site
298654012328	activation loop (A-loop); other site
298654012329	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
298654012330	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
298654012331	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
298654012332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012333	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654012334	NAD(P) binding site [chemical binding]; other site
298654012335	active site
298654012336	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
298654012337	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654012338	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654012339	ligand binding site [chemical binding]; other site
298654012340	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654012341	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654012342	short chain dehydrogenase; Validated; Region: PRK06182
298654012343	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
298654012344	NADP binding site [chemical binding]; other site
298654012345	active site
298654012346	steroid binding site; other site
298654012347	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012348	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012351	RNA polymerase factor sigma-70; Validated; Region: PRK08241
298654012352	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654012353	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654012354	DNA binding residues [nucleotide binding]
298654012355	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654012356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012357	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654012358	putative substrate translocation pore; other site
298654012359	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012361	NAD(P) binding site [chemical binding]; other site
298654012362	active site
298654012363	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
298654012364	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654012365	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654012366	structural tetrad; other site
298654012367	RHS Repeat; Region: RHS_repeat; pfam05593
298654012368	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
298654012369	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
298654012370	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654012371	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654012372	Cupin domain; Region: Cupin_2; cl17218
298654012373	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298654012374	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654012375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654012376	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654012377	active site
298654012378	metal binding site [ion binding]; metal-binding site
298654012379	Amino acid permease; Region: AA_permease_2; pfam13520
298654012380	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
298654012381	Cupin; Region: Cupin_6; pfam12852
298654012382	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654012383	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654012384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654012385	Predicted acyl esterases [General function prediction only]; Region: COG2936
298654012386	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
298654012387	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
298654012388	Short C-terminal domain; Region: SHOCT; pfam09851
298654012389	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
298654012390	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654012391	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654012392	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
298654012393	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654012394	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654012395	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654012396	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654012397	putative ligand binding site [chemical binding]; other site
298654012398	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
298654012399	Domain of unknown function DUF20; Region: UPF0118; pfam01594
298654012400	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
298654012401	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654012402	Histidine kinase; Region: HisKA_3; pfam07730
298654012403	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654012404	ATP binding site [chemical binding]; other site
298654012405	Mg2+ binding site [ion binding]; other site
298654012406	G-X-G motif; other site
298654012407	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654012408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654012409	active site
298654012410	phosphorylation site [posttranslational modification]
298654012411	intermolecular recognition site; other site
298654012412	dimerization interface [polypeptide binding]; other site
298654012413	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654012414	DNA binding residues [nucleotide binding]
298654012415	dimerization interface [polypeptide binding]; other site
298654012416	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654012417	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654012418	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298654012419	classical (c) SDRs; Region: SDR_c; cd05233
298654012420	NAD(P) binding site [chemical binding]; other site
298654012421	active site
298654012422	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654012423	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654012424	substrate binding site [chemical binding]; other site
298654012425	oxyanion hole (OAH) forming residues; other site
298654012426	trimer interface [polypeptide binding]; other site
298654012427	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
298654012428	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
298654012429	putative metal binding site [ion binding]; other site
298654012430	Uncharacterized conserved protein [Function unknown]; Region: COG1432
298654012431	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
298654012432	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
298654012433	dimer interface [polypeptide binding]; other site
298654012434	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654012435	ligand binding site [chemical binding]; other site
298654012436	Predicted transcriptional regulator [Transcription]; Region: COG2378
298654012437	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654012438	dimerization interface [polypeptide binding]; other site
298654012439	putative Zn2+ binding site [ion binding]; other site
298654012440	putative DNA binding site [nucleotide binding]; other site
298654012441	WYL domain; Region: WYL; pfam13280
298654012442	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654012443	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654012444	active site
298654012445	metal binding site [ion binding]; metal-binding site
298654012446	TIR domain; Region: TIR_2; pfam13676
298654012447	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654012448	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654012449	structural tetrad; other site
298654012450	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
298654012451	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
298654012452	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
298654012453	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654012454	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654012455	YCII-related domain; Region: YCII; cl00999
298654012456	Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; Region: SRPBCC_Aha1; cd08892
298654012457	putative hydrophobic ligand binding site [chemical binding]; other site
298654012458	putative Hsp90 binding residues [polypeptide binding]; other site
298654012459	cyanate hydratase; Validated; Region: PRK02866
298654012460	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
298654012461	oligomer interface [polypeptide binding]; other site
298654012462	active site
298654012463	NB-ARC domain; Region: NB-ARC; pfam00931
298654012464	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012465	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012466	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012467	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012468	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012469	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012470	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012471	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012472	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012473	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654012474	Tetratricopeptide repeat; Region: TPR_10; cl17452
298654012475	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654012476	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654012477	active site
298654012478	catalytic tetrad [active]
298654012479	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
298654012480	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
298654012481	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654012482	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654012483	Response regulator receiver domain; Region: Response_reg; pfam00072
298654012484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654012485	active site
298654012486	phosphorylation site [posttranslational modification]
298654012487	intermolecular recognition site; other site
298654012488	dimerization interface [polypeptide binding]; other site
298654012489	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654012490	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654012491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
298654012492	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
298654012493	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
298654012494	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
298654012495	[4Fe-4S] binding site [ion binding]; other site
298654012496	molybdopterin cofactor binding site; other site
298654012497	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
298654012498	molybdopterin cofactor binding site; other site
298654012499	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
298654012500	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298654012501	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
298654012502	FAD binding pocket [chemical binding]; other site
298654012503	FAD binding motif [chemical binding]; other site
298654012504	catalytic residues [active]
298654012505	NAD binding pocket [chemical binding]; other site
298654012506	phosphate binding motif [ion binding]; other site
298654012507	beta-alpha-beta structure motif; other site
298654012508	nitrite reductase subunit NirD; Provisional; Region: PRK14989
298654012509	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654012510	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298654012511	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298654012512	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298654012513	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
298654012514	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
298654012515	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
298654012516	active site
298654012517	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654012518	DNA binding site [nucleotide binding]
298654012519	Restriction endonuclease; Region: Mrr_cat; pfam04471
298654012520	Caspase domain; Region: Peptidase_C14; pfam00656
298654012521	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654012522	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654012523	active site
298654012524	ATP binding site [chemical binding]; other site
298654012525	substrate binding site [chemical binding]; other site
298654012526	activation loop (A-loop); other site
298654012527	SpaB C-terminal domain; Region: SpaB_C; cl14828
298654012528	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
298654012529	apolar tunnel; other site
298654012530	heme binding site [chemical binding]; other site
298654012531	dimerization interface [polypeptide binding]; other site
298654012532	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
298654012533	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
298654012534	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
298654012535	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
298654012536	active site
298654012537	nucleophile elbow; other site
298654012538	Fatty acid desaturase; Region: FA_desaturase; pfam00487
298654012539	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
298654012540	putative di-iron ligands [ion binding]; other site
298654012541	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
298654012542	GAF domain; Region: GAF_2; pfam13185
298654012543	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
298654012544	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
298654012545	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
298654012546	siderophore binding site; other site
298654012547	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298654012548	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
298654012549	acyl-activating enzyme (AAE) consensus motif; other site
298654012550	AMP binding site [chemical binding]; other site
298654012551	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298654012552	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
298654012553	acyl-activating enzyme (AAE) consensus motif; other site
298654012554	AMP binding site [chemical binding]; other site
298654012555	YqcI/YcgG family; Region: YqcI_YcgG; pfam08892
298654012556	MbtH-like protein; Region: MbtH; cl01279
298654012557	Condensation domain; Region: Condensation; pfam00668
298654012558	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654012559	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
298654012560	acyl-activating enzyme (AAE) consensus motif; other site
298654012561	AMP binding site [chemical binding]; other site
298654012562	active site
298654012563	CoA binding site [chemical binding]; other site
298654012564	Condensation domain; Region: Condensation; pfam00668
298654012565	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298654012566	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
298654012567	acyl-activating enzyme (AAE) consensus motif; other site
298654012568	AMP binding site [chemical binding]; other site
298654012569	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654012570	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
298654012571	Condensation domain; Region: Condensation; pfam00668
298654012572	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298654012573	FERM N-terminal domain; Region: FERM_N; pfam09379
298654012574	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654012575	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298654012576	acyl-activating enzyme (AAE) consensus motif; other site
298654012577	AMP binding site [chemical binding]; other site
298654012578	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654012579	S-adenosylmethionine binding site [chemical binding]; other site
298654012580	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654012581	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654012582	Condensation domain; Region: Condensation; pfam00668
298654012583	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298654012584	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
298654012585	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298654012586	acyl-activating enzyme (AAE) consensus motif; other site
298654012587	AMP binding site [chemical binding]; other site
298654012588	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654012589	Condensation domain; Region: Condensation; pfam00668
298654012590	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298654012591	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
298654012592	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654012593	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
298654012594	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
298654012595	acyl-activating enzyme (AAE) consensus motif; other site
298654012596	active site
298654012597	AMP binding site [chemical binding]; other site
298654012598	substrate binding site [chemical binding]; other site
298654012599	salicylate synthase; Region: salicyl_syn; TIGR03494
298654012600	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
298654012601	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
298654012602	Condensation domain; Region: Condensation; pfam00668
298654012603	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298654012604	Nonribosomal peptide synthase; Region: NRPS; pfam08415
298654012605	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
298654012606	acyl-activating enzyme (AAE) consensus motif; other site
298654012607	AMP binding site [chemical binding]; other site
298654012608	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654012609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
298654012610	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654012611	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654012612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654012613	Walker A/P-loop; other site
298654012614	ATP binding site [chemical binding]; other site
298654012615	Q-loop/lid; other site
298654012616	ABC transporter signature motif; other site
298654012617	Walker B; other site
298654012618	D-loop; other site
298654012619	H-loop/switch region; other site
298654012620	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654012621	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654012622	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654012623	Walker A/P-loop; other site
298654012624	ATP binding site [chemical binding]; other site
298654012625	Q-loop/lid; other site
298654012626	ABC transporter signature motif; other site
298654012627	Walker B; other site
298654012628	D-loop; other site
298654012629	H-loop/switch region; other site
298654012630	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
298654012631	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654012632	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
298654012633	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298654012634	putative PBP binding regions; other site
298654012635	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
298654012636	ABC-ATPase subunit  interface; other site
298654012637	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
298654012638	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298654012639	ABC-ATPase subunit  interface; other site
298654012640	dimer interface [polypeptide binding]; other site
298654012641	putative PBP binding regions; other site
298654012642	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
298654012643	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
298654012644	Walker A/P-loop; other site
298654012645	ATP binding site [chemical binding]; other site
298654012646	Q-loop/lid; other site
298654012647	ABC transporter signature motif; other site
298654012648	Walker B; other site
298654012649	D-loop; other site
298654012650	H-loop/switch region; other site
298654012651	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654012652	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654012653	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654012654	Walker A/P-loop; other site
298654012655	ATP binding site [chemical binding]; other site
298654012656	Q-loop/lid; other site
298654012657	ABC transporter signature motif; other site
298654012658	Walker B; other site
298654012659	D-loop; other site
298654012660	H-loop/switch region; other site
298654012661	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654012662	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654012663	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654012664	Walker A/P-loop; other site
298654012665	ATP binding site [chemical binding]; other site
298654012666	Q-loop/lid; other site
298654012667	ABC transporter signature motif; other site
298654012668	Walker B; other site
298654012669	D-loop; other site
298654012670	H-loop/switch region; other site
298654012671	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654012672	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654012673	active site
298654012674	ATP binding site [chemical binding]; other site
298654012675	substrate binding site [chemical binding]; other site
298654012676	activation loop (A-loop); other site
298654012677	NHL repeat; Region: NHL; pfam01436
298654012678	NHL repeat; Region: NHL; pfam01436
298654012679	NHL repeat; Region: NHL; pfam01436
298654012680	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654012681	active site
298654012682	ATP binding site [chemical binding]; other site
298654012683	substrate binding site [chemical binding]; other site
298654012684	activation loop (A-loop); other site
298654012685	NHL repeat; Region: NHL; pfam01436
298654012686	NHL repeat; Region: NHL; pfam01436
298654012687	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654012688	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654012689	active site
298654012690	ATP binding site [chemical binding]; other site
298654012691	substrate binding site [chemical binding]; other site
298654012692	activation loop (A-loop); other site
298654012693	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654012694	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654012695	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
298654012696	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654012697	dimer interface [polypeptide binding]; other site
298654012698	active site
298654012699	short chain dehydrogenase; Provisional; Region: PRK06197
298654012700	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
298654012701	putative NAD(P) binding site [chemical binding]; other site
298654012702	active site
298654012703	classical (c) SDRs; Region: SDR_c; cd05233
298654012704	acetoin reductase; Validated; Region: PRK08643
298654012705	NAD(P) binding site [chemical binding]; other site
298654012706	active site
298654012707	Predicted membrane protein [Function unknown]; Region: COG4270
298654012708	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298654012709	Beta-lactamase; Region: Beta-lactamase; pfam00144
298654012710	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654012711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654012712	active site
298654012713	phosphorylation site [posttranslational modification]
298654012714	intermolecular recognition site; other site
298654012715	dimerization interface [polypeptide binding]; other site
298654012716	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654012717	DNA binding site [nucleotide binding]
298654012718	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654012719	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654012720	dimer interface [polypeptide binding]; other site
298654012721	phosphorylation site [posttranslational modification]
298654012722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654012723	ATP binding site [chemical binding]; other site
298654012724	Mg2+ binding site [ion binding]; other site
298654012725	G-X-G motif; other site
298654012726	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
298654012727	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
298654012728	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
298654012729	active site
298654012730	non-prolyl cis peptide bond; other site
298654012731	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654012732	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654012733	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654012734	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654012735	DNA-binding site [nucleotide binding]; DNA binding site
298654012736	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298654012737	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
298654012738	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654012739	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654012740	putative ligand binding site [chemical binding]; other site
298654012741	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
298654012742	active site
298654012743	catalytic triad [active]
298654012744	oxyanion hole [active]
298654012745	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654012746	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
298654012747	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
298654012748	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298654012749	G2 box; other site
298654012750	Switch I region; other site
298654012751	G3 box; other site
298654012752	Switch II region; other site
298654012753	G4 box; other site
298654012754	G5 box; other site
298654012755	Protein of unknown function (DUF742); Region: DUF742; pfam05331
298654012756	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
298654012757	Nitrate and nitrite sensing; Region: NIT; pfam08376
298654012758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654012759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654012760	ATP binding site [chemical binding]; other site
298654012761	Mg2+ binding site [ion binding]; other site
298654012762	G-X-G motif; other site
298654012763	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
298654012764	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654012765	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654012766	DNA binding residues [nucleotide binding]
298654012767	dimerization interface [polypeptide binding]; other site
298654012768	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298654012769	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012770	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012772	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654012773	putative substrate translocation pore; other site
298654012774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654012775	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654012776	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654012777	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654012778	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
298654012779	active site
298654012780	metal-binding site [ion binding]
298654012781	AAA domain; Region: AAA_33; pfam13671
298654012782	nucleotide-binding site [chemical binding]; other site
298654012783	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
298654012784	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
298654012785	Ligand Binding Site [chemical binding]; other site
298654012786	Molecular Tunnel; other site
298654012787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654012788	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654012789	Walker A/P-loop; other site
298654012790	ATP binding site [chemical binding]; other site
298654012791	Q-loop/lid; other site
298654012792	ABC transporter signature motif; other site
298654012793	Walker B; other site
298654012794	D-loop; other site
298654012795	H-loop/switch region; other site
298654012796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
298654012799	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654012800	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654012801	GAF domain; Region: GAF_3; pfam13492
298654012802	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654012803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654012804	Histidine kinase; Region: HisKA_3; pfam07730
298654012805	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654012806	ATP binding site [chemical binding]; other site
298654012807	Mg2+ binding site [ion binding]; other site
298654012808	G-X-G motif; other site
298654012809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012811	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654012812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654012813	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654012814	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654012815	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654012816	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654012817	active site
298654012818	metal binding site [ion binding]; metal-binding site
298654012819	Domain of unknown function (DUF336); Region: DUF336; cl01249
298654012820	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
298654012821	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
298654012822	active site
298654012823	putative substrate binding pocket [chemical binding]; other site
298654012824	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654012825	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654012826	active site
298654012827	ApbE family; Region: ApbE; pfam02424
298654012828	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
298654012829	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
298654012830	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654012831	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654012832	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654012833	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
298654012834	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
298654012835	putative trimer interface [polypeptide binding]; other site
298654012836	putative CoA binding site [chemical binding]; other site
298654012837	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654012838	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654012839	active site
298654012840	ATP binding site [chemical binding]; other site
298654012841	substrate binding site [chemical binding]; other site
298654012842	activation loop (A-loop); other site
298654012843	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
298654012844	FOG: WD40-like repeat [Function unknown]; Region: COG1520
298654012845	Trp docking motif [polypeptide binding]; other site
298654012846	active site
298654012847	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
298654012848	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654012849	active site
298654012850	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
298654012851	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
298654012852	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654012853	Walker A motif; other site
298654012854	ATP binding site [chemical binding]; other site
298654012855	Walker B motif; other site
298654012856	arginine finger; other site
298654012857	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
298654012858	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
298654012859	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
298654012860	putative NAD(P) binding site [chemical binding]; other site
298654012861	putative substrate binding site [chemical binding]; other site
298654012862	catalytic Zn binding site [ion binding]; other site
298654012863	structural Zn binding site [ion binding]; other site
298654012864	dimer interface [polypeptide binding]; other site
298654012865	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654012866	active site
298654012867	catalytic triad [active]
298654012868	hypothetical protein; Provisional; Region: PRK07906
298654012869	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
298654012870	putative metal binding site [ion binding]; other site
298654012871	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654012872	dimerization interface [polypeptide binding]; other site
298654012873	putative DNA binding site [nucleotide binding]; other site
298654012874	putative Zn2+ binding site [ion binding]; other site
298654012875	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
298654012876	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
298654012877	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298654012878	RNA-binding motif; other site
298654012879	DNA-binding site [nucleotide binding]; DNA binding site
298654012880	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654012881	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654012882	metal binding site [ion binding]; metal-binding site
298654012883	active site
298654012884	I-site; other site
298654012885	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
298654012886	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
298654012887	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
298654012888	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654012889	substrate binding pocket [chemical binding]; other site
298654012890	catalytic triad [active]
298654012891	malate dehydrogenase; Provisional; Region: PRK05442
298654012892	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
298654012893	NAD(P) binding site [chemical binding]; other site
298654012894	dimer interface [polypeptide binding]; other site
298654012895	malate binding site [chemical binding]; other site
298654012896	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654012897	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
298654012898	NAD(P) binding site [chemical binding]; other site
298654012899	catalytic residues [active]
298654012900	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
298654012901	FAD binding site [chemical binding]; other site
298654012902	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
298654012903	cytosine deaminase; Validated; Region: PRK07572
298654012904	active site
298654012905	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654012906	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654012907	Walker A/P-loop; other site
298654012908	ATP binding site [chemical binding]; other site
298654012909	Q-loop/lid; other site
298654012910	ABC transporter signature motif; other site
298654012911	Walker B; other site
298654012912	D-loop; other site
298654012913	H-loop/switch region; other site
298654012914	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654012915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654012916	dimer interface [polypeptide binding]; other site
298654012917	conserved gate region; other site
298654012918	putative PBP binding loops; other site
298654012919	ABC-ATPase subunit interface; other site
298654012920	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654012921	FAD binding domain; Region: FAD_binding_4; pfam01565
298654012922	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172
298654012923	reactive center loop; other site
298654012924	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
298654012925	nudix motif; other site
298654012926	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654012927	DNA-binding site [nucleotide binding]; DNA binding site
298654012928	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
298654012929	UTRA domain; Region: UTRA; pfam07702
298654012930	S-adenosyl-L-homocysteine hydrolase, NAD binding domain; Region: AdoHcyase_NAD; smart00997
298654012931	NAD binding site [chemical binding]; other site
298654012932	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
298654012933	nudix motif; other site
298654012934	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
298654012935	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654012936	Creatinine amidohydrolase; Region: Creatininase; pfam02633
298654012937	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654012938	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
298654012939	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
298654012940	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
298654012941	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654012942	inhibitor-cofactor binding pocket; inhibition site
298654012943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654012944	catalytic residue [active]
298654012945	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654012946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654012947	NAD(P) binding site [chemical binding]; other site
298654012948	active site
298654012949	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
298654012950	active site
298654012951	catalytic triad [active]
298654012952	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012953	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012954	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654012956	binding surface
298654012957	TPR motif; other site
298654012958	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654012959	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
298654012960	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
298654012961	putative molybdopterin cofactor binding site [chemical binding]; other site
298654012962	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
298654012963	putative molybdopterin cofactor binding site; other site
298654012964	putative acetyltransferase; Provisional; Region: PRK03624
298654012965	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654012966	Coenzyme A binding pocket [chemical binding]; other site
298654012967	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654012968	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
298654012969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654012970	dimer interface [polypeptide binding]; other site
298654012971	phosphorylation site [posttranslational modification]
298654012972	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654012973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654012974	active site
298654012975	phosphorylation site [posttranslational modification]
298654012976	intermolecular recognition site; other site
298654012977	dimerization interface [polypeptide binding]; other site
298654012978	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654012979	DNA binding site [nucleotide binding]
298654012980	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
298654012981	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
298654012982	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
298654012983	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
298654012984	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654012985	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
298654012986	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654012987	Zn binding site [ion binding]; other site
298654012988	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654012989	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298654012990	catalytic residues [active]
298654012991	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
298654012992	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
298654012993	DNA binding residues [nucleotide binding]
298654012994	putative dimer interface [polypeptide binding]; other site
298654012995	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654012996	classical (c) SDRs; Region: SDR_c; cd05233
298654012997	NAD(P) binding site [chemical binding]; other site
298654012998	active site
298654012999	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654013000	Epoxide hydrolase N terminus; Region: EHN; pfam06441
298654013001	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654013002	PAC2 family; Region: PAC2; pfam09754
298654013003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654013004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654013005	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
298654013006	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654013007	mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996
298654013008	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654013009	phosphate binding site [ion binding]; other site
298654013010	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
298654013011	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
298654013012	putative active site [active]
298654013013	putative FMN binding site [chemical binding]; other site
298654013014	putative substrate binding site [chemical binding]; other site
298654013015	putative catalytic residue [active]
298654013016	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
298654013017	oxidoreductase; Provisional; Region: PRK10015
298654013018	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
298654013019	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
298654013020	Ligand Binding Site [chemical binding]; other site
298654013021	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
298654013022	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
298654013023	AAA ATPase domain; Region: AAA_16; pfam13191
298654013024	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654013025	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654013026	DNA binding residues [nucleotide binding]
298654013027	dimerization interface [polypeptide binding]; other site
298654013028	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654013029	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
298654013030	Walker A/P-loop; other site
298654013031	ATP binding site [chemical binding]; other site
298654013032	Q-loop/lid; other site
298654013033	ABC transporter signature motif; other site
298654013034	Walker B; other site
298654013035	D-loop; other site
298654013036	H-loop/switch region; other site
298654013037	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
298654013038	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
298654013039	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
298654013040	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
298654013041	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
298654013042	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
298654013043	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654013044	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
298654013045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654013046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654013047	homodimer interface [polypeptide binding]; other site
298654013048	catalytic residue [active]
298654013049	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654013050	classical (c) SDRs; Region: SDR_c; cd05233
298654013051	NAD(P) binding site [chemical binding]; other site
298654013052	active site
298654013053	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654013054	MarR family; Region: MarR_2; cl17246
298654013055	Proline dehydrogenase; Region: Pro_dh; cl03282
298654013056	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
298654013057	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
298654013058	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
298654013059	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
298654013060	homodimer interface [polypeptide binding]; other site
298654013061	substrate-cofactor binding pocket; other site
298654013062	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654013063	catalytic residue [active]
298654013064	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
298654013065	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
298654013066	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
298654013067	putative active site [active]
298654013068	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
298654013069	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
298654013070	Walker A/P-loop; other site
298654013071	ATP binding site [chemical binding]; other site
298654013072	Q-loop/lid; other site
298654013073	ABC transporter signature motif; other site
298654013074	Walker B; other site
298654013075	D-loop; other site
298654013076	H-loop/switch region; other site
298654013077	TOBE domain; Region: TOBE_2; pfam08402
298654013078	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298654013079	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654013080	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
298654013081	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
298654013082	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
298654013083	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
298654013084	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298654013085	active site
298654013086	metal binding site [ion binding]; metal-binding site
298654013087	hexamer interface [polypeptide binding]; other site
298654013088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654013089	dimer interface [polypeptide binding]; other site
298654013090	conserved gate region; other site
298654013091	ABC-ATPase subunit interface; other site
298654013092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298654013093	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654013094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654013095	dimer interface [polypeptide binding]; other site
298654013096	conserved gate region; other site
298654013097	putative PBP binding loops; other site
298654013098	ABC-ATPase subunit interface; other site
298654013099	diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830
298654013100	active site
298654013101	ADP/pyrophosphate binding site [chemical binding]; other site
298654013102	allosteric effector site; other site
298654013103	dimerization interface [polypeptide binding]; other site
298654013104	fructose-1,6-bisphosphate binding site; other site
298654013105	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
298654013106	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
298654013107	catalytic residues [active]
298654013108	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654013109	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654013110	putative ligand binding site [chemical binding]; other site
298654013111	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298654013112	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
298654013113	AsnC family; Region: AsnC_trans_reg; pfam01037
298654013114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654013115	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654013116	putative substrate translocation pore; other site
298654013117	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654013118	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654013119	DNA-binding site [nucleotide binding]; DNA binding site
298654013120	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
298654013121	UTRA domain; Region: UTRA; pfam07702
298654013122	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654013123	classical (c) SDRs; Region: SDR_c; cd05233
298654013124	NAD(P) binding site [chemical binding]; other site
298654013125	active site
298654013126	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298654013127	active site
298654013128	ATP binding site [chemical binding]; other site
298654013129	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
298654013130	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654013131	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654013132	catalytic residue [active]
298654013133	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
298654013134	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
298654013135	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
298654013136	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
298654013137	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654013138	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654013139	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654013140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654013141	Walker A/P-loop; other site
298654013142	ATP binding site [chemical binding]; other site
298654013143	Q-loop/lid; other site
298654013144	ABC transporter signature motif; other site
298654013145	Walker B; other site
298654013146	D-loop; other site
298654013147	H-loop/switch region; other site
298654013148	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654013149	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654013150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654013151	Walker A/P-loop; other site
298654013152	ATP binding site [chemical binding]; other site
298654013153	Q-loop/lid; other site
298654013154	ABC transporter signature motif; other site
298654013155	Walker B; other site
298654013156	D-loop; other site
298654013157	H-loop/switch region; other site
298654013158	MarR family; Region: MarR_2; cl17246
298654013159	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
298654013160	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654013161	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
298654013162	conserved cys residue [active]
298654013163	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654013164	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
298654013165	active site
298654013166	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
298654013167	active site
298654013168	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654013169	S-adenosylmethionine binding site [chemical binding]; other site
298654013170	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
298654013171	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
298654013172	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
298654013173	putative active site [active]
298654013174	putative substrate binding site [chemical binding]; other site
298654013175	putative cosubstrate binding site; other site
298654013176	catalytic site [active]
298654013177	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
298654013178	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654013179	active site 2 [active]
298654013180	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298654013181	Ligand Binding Site [chemical binding]; other site
298654013182	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654013183	nucleotide binding site [chemical binding]; other site
298654013184	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654013185	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
298654013186	Copper resistance protein D; Region: CopD; cl00563
298654013187	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
298654013188	CopC domain; Region: CopC; pfam04234
298654013189	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
298654013190	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
298654013191	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
298654013192	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
298654013193	active site residue [active]
298654013194	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
298654013195	active site residue [active]
298654013196	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654013197	Carboxylesterase family; Region: COesterase; pfam00135
298654013198	substrate binding pocket [chemical binding]; other site
298654013199	catalytic triad [active]
298654013200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654013201	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654013202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654013203	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654013204	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654013205	hypothetical protein; Provisional; Region: PRK11770
298654013206	Domain of unknown function (DUF307); Region: DUF307; pfam03733
298654013207	Domain of unknown function (DUF307); Region: DUF307; pfam03733
298654013208	hypothetical protein; Provisional; Region: PRK06185
298654013209	hypothetical protein; Provisional; Region: PRK07236
298654013210	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654013211	DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298
298654013212	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
298654013213	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
298654013214	active site
298654013215	DNA binding site [nucleotide binding]
298654013216	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
298654013217	DNA binding site [nucleotide binding]
298654013218	Protein of unknown function (DUF429); Region: DUF429; cl12046
298654013219	O-methyltransferase; Region: Methyltransf_2; pfam00891
298654013220	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
298654013221	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
298654013222	homodimer interface [polypeptide binding]; other site
298654013223	active site
298654013224	TDP-binding site; other site
298654013225	acceptor substrate-binding pocket; other site
298654013226	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
298654013227	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
298654013228	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654013229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654013230	NAD(P) binding site [chemical binding]; other site
298654013231	active site
298654013232	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
298654013233	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654013234	active site
298654013235	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298654013236	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
298654013237	dimer interface [polypeptide binding]; other site
298654013238	active site
298654013239	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
298654013240	N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860
298654013241	putative hydrophobic ligand binding site [chemical binding]; other site
298654013242	active site
298654013243	catalytic residues_2 [active]
298654013244	catalytic residues_1 [active]
298654013245	Phosphopantetheine attachment site; Region: PP-binding; cl09936
298654013246	Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673
298654013247	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654013248	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654013249	dimerization interface [polypeptide binding]; other site
298654013250	DNA binding residues [nucleotide binding]
298654013251	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298654013252	G2 box; other site
298654013253	Switch I region; other site
298654013254	G3 box; other site
298654013255	Switch II region; other site
298654013256	GTP/Mg2+ binding site [chemical binding]; other site
298654013257	G4 box; other site
298654013258	G5 box; other site
298654013259	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
298654013260	Nitrate and nitrite sensing; Region: NIT; pfam08376
298654013261	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654013262	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298654013263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654013264	ATP binding site [chemical binding]; other site
298654013265	Mg2+ binding site [ion binding]; other site
298654013266	G-X-G motif; other site
298654013267	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
298654013268	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654013269	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
298654013270	acyl-activating enzyme (AAE) consensus motif; other site
298654013271	putative AMP binding site [chemical binding]; other site
298654013272	putative active site [active]
298654013273	putative CoA binding site [chemical binding]; other site
298654013274	hypothetical protein; Provisional; Region: PRK08317
298654013275	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654013276	S-adenosylmethionine binding site [chemical binding]; other site
298654013277	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
298654013278	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654013279	dimer interface [polypeptide binding]; other site
298654013280	putative metal binding site [ion binding]; other site
298654013281	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654013282	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654013283	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654013284	Putative sensor; Region: Sensor; pfam13796
298654013285	Histidine kinase; Region: HisKA_3; pfam07730
298654013286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654013287	ATP binding site [chemical binding]; other site
298654013288	Mg2+ binding site [ion binding]; other site
298654013289	G-X-G motif; other site
298654013290	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
298654013291	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
298654013292	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
298654013293	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
298654013294	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
298654013295	active site
298654013296	AAA ATPase domain; Region: AAA_16; pfam13191
298654013297	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654013298	structural tetrad; other site
298654013299	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654013300	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654013301	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654013302	structural tetrad; other site
298654013303	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654013304	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654013305	active site
298654013306	ATP binding site [chemical binding]; other site
298654013307	substrate binding site [chemical binding]; other site
298654013308	activation loop (A-loop); other site
298654013309	NHL repeat; Region: NHL; pfam01436
298654013310	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654013311	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654013312	active site
298654013313	catalytic tetrad [active]
298654013314	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
298654013315	active site
298654013316	enoyl-CoA hydratase; Provisional; Region: PRK07799
298654013317	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654013318	substrate binding site [chemical binding]; other site
298654013319	oxyanion hole (OAH) forming residues; other site
298654013320	trimer interface [polypeptide binding]; other site
298654013321	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654013322	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654013323	Coenzyme A binding pocket [chemical binding]; other site
298654013324	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
298654013325	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
298654013326	active site
298654013327	dimer interface [polypeptide binding]; other site
298654013328	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
298654013329	Ligand Binding Site [chemical binding]; other site
298654013330	Molecular Tunnel; other site
298654013331	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
298654013332	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
298654013333	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
298654013334	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
298654013335	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654013336	CoenzymeA binding site [chemical binding]; other site
298654013337	subunit interaction site [polypeptide binding]; other site
298654013338	PHB binding site; other site
298654013339	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654013340	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654013341	DNA-binding site [nucleotide binding]; DNA binding site
298654013342	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298654013343	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654013344	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298654013345	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654013346	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
298654013347	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654013348	Walker A/P-loop; other site
298654013349	ATP binding site [chemical binding]; other site
298654013350	Q-loop/lid; other site
298654013351	ABC transporter signature motif; other site
298654013352	Walker B; other site
298654013353	D-loop; other site
298654013354	H-loop/switch region; other site
298654013355	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
298654013356	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654013357	Walker A/P-loop; other site
298654013358	ATP binding site [chemical binding]; other site
298654013359	Q-loop/lid; other site
298654013360	ABC transporter signature motif; other site
298654013361	Walker B; other site
298654013362	D-loop; other site
298654013363	H-loop/switch region; other site
298654013364	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654013365	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654013366	TM-ABC transporter signature motif; other site
298654013367	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654013368	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654013369	TM-ABC transporter signature motif; other site
298654013370	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654013371	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
298654013372	putative ligand binding site [chemical binding]; other site
298654013373	PAS fold; Region: PAS_3; pfam08447
298654013374	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654013375	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654013376	metal binding site [ion binding]; metal-binding site
298654013377	active site
298654013378	I-site; other site
298654013379	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654013380	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
298654013381	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
298654013382	heme binding site [chemical binding]; other site
298654013383	ferroxidase pore; other site
298654013384	ferroxidase diiron center [ion binding]; other site
298654013385	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298654013386	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298654013387	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298654013388	ligand binding site [chemical binding]; other site
298654013389	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
298654013390	active site
298654013391	Bacterial Ig-like domain; Region: Big_5; pfam13205
298654013392	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
298654013393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
298654013394	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298654013395	urate oxidase; Region: urate_oxi; TIGR03383
298654013396	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
298654013397	active site
298654013398	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
298654013399	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654013400	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654013401	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
298654013402	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654013403	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654013404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654013405	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
298654013406	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
298654013407	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
298654013408	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
298654013409	ferrochelatase; Reviewed; Region: hemH; PRK00035
298654013410	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
298654013411	C-terminal domain interface [polypeptide binding]; other site
298654013412	active site
298654013413	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
298654013414	active site
298654013415	N-terminal domain interface [polypeptide binding]; other site
298654013416	short chain dehydrogenase; Provisional; Region: PRK06523
298654013417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654013418	NAD(P) binding site [chemical binding]; other site
298654013419	active site
298654013420	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
298654013421	TPP-binding site [chemical binding]; other site
298654013422	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654013423	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
298654013424	binding surface
298654013425	TPR motif; other site
298654013426	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654013427	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
298654013428	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
298654013429	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
298654013430	TrkA-C domain; Region: TrkA_C; pfam02080
298654013431	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
298654013432	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
298654013433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654013434	NAD(P) binding site [chemical binding]; other site
298654013435	active site
298654013436	hypothetical protein; Provisional; Region: PRK01346
298654013437	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
298654013438	Predicted dehydrogenase [General function prediction only]; Region: COG0579
298654013439	hydroxyglutarate oxidase; Provisional; Region: PRK11728
298654013440	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
298654013441	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
298654013442	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
298654013443	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654013444	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654013445	NAD(P) binding site [chemical binding]; other site
298654013446	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654013447	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298654013448	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654013449	catalytic residue [active]
298654013450	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
298654013451	Peptidase family M28; Region: Peptidase_M28; pfam04389
298654013452	metal binding site [ion binding]; metal-binding site
298654013453	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
298654013454	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
298654013455	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654013456	nucleotide binding site [chemical binding]; other site
298654013457	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654013458	SBD interface [polypeptide binding]; other site
298654013459	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654013460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654013461	DNA binding residues [nucleotide binding]
298654013462	dimerization interface [polypeptide binding]; other site
298654013463	pyruvate kinase; Provisional; Region: PRK06247
298654013464	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
298654013465	domain interfaces; other site
298654013466	active site
298654013467	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
298654013468	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654013469	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654013470	Walker A/P-loop; other site
298654013471	ATP binding site [chemical binding]; other site
298654013472	Q-loop/lid; other site
298654013473	ABC transporter signature motif; other site
298654013474	Walker B; other site
298654013475	D-loop; other site
298654013476	H-loop/switch region; other site
298654013477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654013478	substrate binding site [chemical binding]; other site
298654013479	oxyanion hole (OAH) forming residues; other site
298654013480	trimer interface [polypeptide binding]; other site
298654013481	Cation efflux family; Region: Cation_efflux; pfam01545
298654013482	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
298654013483	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654013484	Walker A/P-loop; other site
298654013485	ATP binding site [chemical binding]; other site
298654013486	Q-loop/lid; other site
298654013487	ABC transporter signature motif; other site
298654013488	Walker B; other site
298654013489	D-loop; other site
298654013490	H-loop/switch region; other site
298654013491	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654013492	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654013493	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
298654013494	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654013495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
298654013496	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
298654013497	Uncharacterized conserved protein [Function unknown]; Region: COG2308
298654013498	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
298654013499	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
298654013500	NAD binding site [chemical binding]; other site
298654013501	substrate binding site [chemical binding]; other site
298654013502	homodimer interface [polypeptide binding]; other site
298654013503	active site
298654013504	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
298654013505	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
298654013506	ligand binding site; other site
298654013507	oligomer interface; other site
298654013508	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
298654013509	dimer interface [polypeptide binding]; other site
298654013510	N-terminal domain interface [polypeptide binding]; other site
298654013511	sulfate 1 binding site; other site
298654013512	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
298654013513	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654013514	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
298654013515	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
298654013516	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
298654013517	trimerization site [polypeptide binding]; other site
298654013518	active site
298654013519	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298654013520	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
298654013521	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654013522	catalytic residue [active]
298654013523	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
298654013524	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
298654013525	Walker A/P-loop; other site
298654013526	ATP binding site [chemical binding]; other site
298654013527	Q-loop/lid; other site
298654013528	ABC transporter signature motif; other site
298654013529	Walker B; other site
298654013530	D-loop; other site
298654013531	H-loop/switch region; other site
298654013532	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
298654013533	[2Fe-2S] cluster binding site [ion binding]; other site
298654013534	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
298654013535	FeS assembly protein SufD; Region: sufD; TIGR01981
298654013536	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
298654013537	FeS assembly protein SufB; Region: sufB; TIGR01980
298654013538	Predicted transcriptional regulator [Transcription]; Region: COG2345
298654013539	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654013540	putative DNA binding site [nucleotide binding]; other site
298654013541	putative Zn2+ binding site [ion binding]; other site
298654013542	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
298654013543	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
298654013544	N- and C-terminal domain interface [polypeptide binding]; other site
298654013545	active site
298654013546	MgATP binding site [chemical binding]; other site
298654013547	catalytic site [active]
298654013548	metal binding site [ion binding]; metal-binding site
298654013549	glycerol binding site [chemical binding]; other site
298654013550	homotetramer interface [polypeptide binding]; other site
298654013551	homodimer interface [polypeptide binding]; other site
298654013552	FBP binding site [chemical binding]; other site
298654013553	protein IIAGlc interface [polypeptide binding]; other site
298654013554	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
298654013555	sequence-specific DNA binding site [nucleotide binding]; other site
298654013556	salt bridge; other site
298654013557	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654013558	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298654013559	Walker A/P-loop; other site
298654013560	ATP binding site [chemical binding]; other site
298654013561	Q-loop/lid; other site
298654013562	ABC transporter signature motif; other site
298654013563	Walker B; other site
298654013564	D-loop; other site
298654013565	H-loop/switch region; other site
298654013566	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654013567	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654013568	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
298654013569	PemK-like protein; Region: PemK; pfam02452
298654013570	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
298654013571	UbiA prenyltransferase family; Region: UbiA; pfam01040
298654013572	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
298654013573	putative active site [active]
298654013574	catalytic residue [active]
298654013575	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
298654013576	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
298654013577	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
298654013578	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
298654013579	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
298654013580	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
298654013581	putative active site [active]
298654013582	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654013583	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654013584	active site
298654013585	ATP binding site [chemical binding]; other site
298654013586	substrate binding site [chemical binding]; other site
298654013587	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654013588	substrate binding site [chemical binding]; other site
298654013589	activation loop (A-loop); other site
298654013590	activation loop (A-loop); other site
298654013591	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
298654013592	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
298654013593	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298654013594	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
298654013595	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654013596	Walker A/P-loop; other site
298654013597	ATP binding site [chemical binding]; other site
298654013598	Q-loop/lid; other site
298654013599	ABC transporter signature motif; other site
298654013600	Walker B; other site
298654013601	D-loop; other site
298654013602	H-loop/switch region; other site
298654013603	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
298654013604	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
298654013605	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298654013606	Walker A/P-loop; other site
298654013607	ATP binding site [chemical binding]; other site
298654013608	Q-loop/lid; other site
298654013609	ABC transporter signature motif; other site
298654013610	Walker B; other site
298654013611	D-loop; other site
298654013612	H-loop/switch region; other site
298654013613	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298654013614	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298654013615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654013616	dimer interface [polypeptide binding]; other site
298654013617	conserved gate region; other site
298654013618	putative PBP binding loops; other site
298654013619	ABC-ATPase subunit interface; other site
298654013620	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
298654013621	peptide binding site [polypeptide binding]; other site
298654013622	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298654013623	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
298654013624	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654013625	dimer interface [polypeptide binding]; other site
298654013626	conserved gate region; other site
298654013627	putative PBP binding loops; other site
298654013628	ABC-ATPase subunit interface; other site
298654013629	triosephosphate isomerase; Provisional; Region: PRK14567
298654013630	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
298654013631	substrate binding site [chemical binding]; other site
298654013632	dimer interface [polypeptide binding]; other site
298654013633	catalytic triad [active]
298654013634	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
298654013635	Phosphoglycerate kinase; Region: PGK; pfam00162
298654013636	substrate binding site [chemical binding]; other site
298654013637	hinge regions; other site
298654013638	ADP binding site [chemical binding]; other site
298654013639	catalytic site [active]
298654013640	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
298654013641	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
298654013642	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
298654013643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
298654013644	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
298654013645	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
298654013646	putative substrate binding pocket [chemical binding]; other site
298654013647	dimer interface [polypeptide binding]; other site
298654013648	phosphate binding site [ion binding]; other site
298654013649	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
298654013650	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
298654013651	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
298654013652	GIY-YIG motif/motif A; other site
298654013653	active site
298654013654	catalytic site [active]
298654013655	putative DNA binding site [nucleotide binding]; other site
298654013656	metal binding site [ion binding]; metal-binding site
298654013657	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
298654013658	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
298654013659	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
298654013660	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654013661	nudix motif; other site
298654013662	Family description; Region: VCBS; pfam13517
298654013663	Family description; Region: VCBS; pfam13517
298654013664	AAA ATPase domain; Region: AAA_16; pfam13191
298654013665	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654013666	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654013667	DNA binding residues [nucleotide binding]
298654013668	dimerization interface [polypeptide binding]; other site
298654013669	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
298654013670	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
298654013671	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
298654013672	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
298654013673	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654013674	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654013675	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
298654013676	WYL domain; Region: WYL; pfam13280
298654013677	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
298654013678	putative substrate binding region [chemical binding]; other site
298654013679	excinuclease ABC subunit B; Provisional; Region: PRK05298
298654013680	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654013681	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654013682	nucleotide binding region [chemical binding]; other site
298654013683	ATP-binding site [chemical binding]; other site
298654013684	Ultra-violet resistance protein B; Region: UvrB; pfam12344
298654013685	UvrB/uvrC motif; Region: UVR; pfam02151
298654013686	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
298654013687	putative active site [active]
298654013688	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
298654013689	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654013690	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654013691	DNA binding residues [nucleotide binding]
298654013692	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
298654013693	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
298654013694	CoA-binding site [chemical binding]; other site
298654013695	ATP-binding [chemical binding]; other site
298654013696	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
298654013697	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
298654013698	active site
298654013699	Zn binding site [ion binding]; other site
298654013700	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
298654013701	aminotransferase; Validated; Region: PRK07046
298654013702	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654013703	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654013704	catalytic residue [active]
298654013705	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
298654013706	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
298654013707	RNA binding site [nucleotide binding]; other site
298654013708	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
298654013709	RNA binding site [nucleotide binding]; other site
298654013710	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
298654013711	RNA binding site [nucleotide binding]; other site
298654013712	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
298654013713	RNA binding site [nucleotide binding]; other site
298654013714	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654013715	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654013716	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
298654013717	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
298654013718	active site
298654013719	catalytic triad [active]
298654013720	oxyanion hole [active]
298654013721	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
298654013722	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
298654013723	NADP-binding site; other site
298654013724	homotetramer interface [polypeptide binding]; other site
298654013725	substrate binding site [chemical binding]; other site
298654013726	homodimer interface [polypeptide binding]; other site
298654013727	active site
298654013728	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654013729	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654013730	CARDB; Region: CARDB; pfam07705
298654013731	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654013732	metal binding site [ion binding]; metal-binding site
298654013733	active site
298654013734	I-site; other site
298654013735	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654013736	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654013737	GAF domain; Region: GAF; pfam01590
298654013738	GAF domain; Region: GAF; pfam01590
298654013739	DNA polymerase I; Provisional; Region: PRK05755
298654013740	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
298654013741	active site
298654013742	metal binding site 1 [ion binding]; metal-binding site
298654013743	putative 5' ssDNA interaction site; other site
298654013744	metal binding site 3; metal-binding site
298654013745	metal binding site 2 [ion binding]; metal-binding site
298654013746	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
298654013747	putative DNA binding site [nucleotide binding]; other site
298654013748	putative metal binding site [ion binding]; other site
298654013749	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
298654013750	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
298654013751	active site
298654013752	DNA binding site [nucleotide binding]
298654013753	catalytic site [active]
298654013754	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654013755	CoenzymeA binding site [chemical binding]; other site
298654013756	subunit interaction site [polypeptide binding]; other site
298654013757	PHB binding site; other site
298654013758	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
298654013759	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654013760	Walker A/P-loop; other site
298654013761	ATP binding site [chemical binding]; other site
298654013762	Q-loop/lid; other site
298654013763	ABC transporter signature motif; other site
298654013764	Walker B; other site
298654013765	D-loop; other site
298654013766	H-loop/switch region; other site
298654013767	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654013768	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654013769	TM-ABC transporter signature motif; other site
298654013770	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
298654013771	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654013772	TM-ABC transporter signature motif; other site
298654013773	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
298654013774	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
298654013775	dimerization interface [polypeptide binding]; other site
298654013776	ligand binding site [chemical binding]; other site
298654013777	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
298654013778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654013779	active site
298654013780	phosphorylation site [posttranslational modification]
298654013781	intermolecular recognition site; other site
298654013782	dimerization interface [polypeptide binding]; other site
298654013783	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
298654013784	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
298654013785	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654013786	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
298654013787	Thioredoxin; Region: Thioredoxin_4; cl17273
298654013788	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
298654013789	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
298654013790	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
298654013791	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654013792	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
298654013793	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298654013794	active site
298654013795	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654013796	catalytic triad [active]
298654013797	dimer interface [polypeptide binding]; other site
298654013798	hypothetical protein; Provisional; Region: PRK07208
298654013799	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654013800	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654013801	active site
298654013802	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
298654013803	Domain of unknown function DUF21; Region: DUF21; pfam01595
298654013804	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
298654013805	Transporter associated domain; Region: CorC_HlyC; smart01091
298654013806	Domain of unknown function DUF21; Region: DUF21; pfam01595
298654013807	FOG: CBS domain [General function prediction only]; Region: COG0517
298654013808	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
298654013809	Protein kinase domain; Region: Pkinase; pfam00069
298654013810	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654013811	active site
298654013812	ATP binding site [chemical binding]; other site
298654013813	substrate binding site [chemical binding]; other site
298654013814	activation loop (A-loop); other site
298654013815	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654013816	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654013817	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654013818	nucleotide binding site [chemical binding]; other site
298654013819	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654013820	SBD interface [polypeptide binding]; other site
298654013821	PBP superfamily domain; Region: PBP_like_2; cl17296
298654013822	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
298654013823	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654013824	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
298654013825	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
298654013826	heterodimer interface [polypeptide binding]; other site
298654013827	substrate interaction site [chemical binding]; other site
298654013828	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
298654013829	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
298654013830	active site
298654013831	substrate binding site [chemical binding]; other site
298654013832	coenzyme B12 binding site [chemical binding]; other site
298654013833	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
298654013834	B12 binding site [chemical binding]; other site
298654013835	cobalt ligand [ion binding]; other site
298654013836	membrane ATPase/protein kinase; Provisional; Region: PRK09435
298654013837	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
298654013838	Walker A; other site
298654013839	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654013840	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654013841	active site
298654013842	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
298654013843	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
298654013844	Moco binding site; other site
298654013845	metal coordination site [ion binding]; other site
298654013846	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
298654013847	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
298654013848	FAD binding pocket [chemical binding]; other site
298654013849	FAD binding motif [chemical binding]; other site
298654013850	phosphate binding motif [ion binding]; other site
298654013851	beta-alpha-beta structure motif; other site
298654013852	NAD binding pocket [chemical binding]; other site
298654013853	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
298654013854	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654013855	glycyl-tRNA synthetase; Provisional; Region: PRK14908
298654013856	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
298654013857	motif 1; other site
298654013858	dimer interface [polypeptide binding]; other site
298654013859	active site
298654013860	motif 2; other site
298654013861	motif 3; other site
298654013862	DALR anticodon binding domain; Region: DALR_1; smart00836
298654013863	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
298654013864	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
298654013865	substrate binding site [polypeptide binding]; other site
298654013866	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
298654013867	Zn binding sites [ion binding]; other site
298654013868	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
298654013869	dimer interface [polypeptide binding]; other site
298654013870	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
298654013871	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654013872	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654013873	NAD(P) binding site [chemical binding]; other site
298654013874	catalytic residues [active]
298654013875	Protein of unknown function (DUF779); Region: DUF779; cl01432
298654013876	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654013877	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654013878	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298654013879	active site
298654013880	catalytic site [active]
298654013881	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654013882	Cytochrome P450; Region: p450; cl12078
298654013883	adenylate kinase; Reviewed; Region: adk; PRK00279
298654013884	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
298654013885	AMP-binding site [chemical binding]; other site
298654013886	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
298654013887	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
298654013888	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654013889	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
298654013890	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
298654013891	active site
298654013892	dimer interface [polypeptide binding]; other site
298654013893	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
298654013894	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
298654013895	active site
298654013896	FMN binding site [chemical binding]; other site
298654013897	substrate binding site [chemical binding]; other site
298654013898	3Fe-4S cluster binding site [ion binding]; other site
298654013899	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
298654013900	domain interface; other site
298654013901	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
298654013902	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
298654013903	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
298654013904	substrate binding site [chemical binding]; other site
298654013905	active site
298654013906	catalytic residues [active]
298654013907	heterodimer interface [polypeptide binding]; other site
298654013908	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
298654013909	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
298654013910	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654013911	catalytic residue [active]
298654013912	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
298654013913	active site
298654013914	substrate (anthranilate) binding pocket [chemical binding]; other site
298654013915	product (indole) binding pocket [chemical binding]; other site
298654013916	ribulose/triose binding site [chemical binding]; other site
298654013917	phosphate binding site [ion binding]; other site
298654013918	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850
298654013919	anthranilate synthase component I; Provisional; Region: PRK13571
298654013920	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
298654013921	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
298654013922	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
298654013923	Cupin domain; Region: Cupin_2; cl17218
298654013924	Isochorismatase family; Region: Isochorismatase; pfam00857
298654013925	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
298654013926	catalytic triad [active]
298654013927	conserved cis-peptide bond; other site
298654013928	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
298654013929	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654013930	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
298654013931	Amidase; Region: Amidase; cl11426
298654013932	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
298654013933	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654013934	non-specific DNA binding site [nucleotide binding]; other site
298654013935	salt bridge; other site
298654013936	sequence-specific DNA binding site [nucleotide binding]; other site
298654013937	Cupin domain; Region: Cupin_2; pfam07883
298654013938	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654013939	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654013940	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654013941	Walker A/P-loop; other site
298654013942	ATP binding site [chemical binding]; other site
298654013943	Q-loop/lid; other site
298654013944	ABC transporter signature motif; other site
298654013945	Walker B; other site
298654013946	D-loop; other site
298654013947	H-loop/switch region; other site
298654013948	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298654013949	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654013950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654013951	Walker A/P-loop; other site
298654013952	ATP binding site [chemical binding]; other site
298654013953	Q-loop/lid; other site
298654013954	ABC transporter signature motif; other site
298654013955	Walker B; other site
298654013956	D-loop; other site
298654013957	H-loop/switch region; other site
298654013958	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
298654013959	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
298654013960	substrate binding site [chemical binding]; other site
298654013961	glutamase interaction surface [polypeptide binding]; other site
298654013962	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
298654013963	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
298654013964	catalytic residues [active]
298654013965	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
298654013966	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
298654013967	Asparagine synthase; Region: Asn_synthase; pfam00733
298654013968	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
298654013969	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
298654013970	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
298654013971	putative active site [active]
298654013972	oxyanion strand; other site
298654013973	catalytic triad [active]
298654013974	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
298654013975	putative active site pocket [active]
298654013976	4-fold oligomerization interface [polypeptide binding]; other site
298654013977	metal binding residues [ion binding]; metal-binding site
298654013978	3-fold/trimer interface [polypeptide binding]; other site
298654013979	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
298654013980	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654013981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654013982	homodimer interface [polypeptide binding]; other site
298654013983	catalytic residue [active]
298654013984	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
298654013985	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
298654013986	NAD binding site [chemical binding]; other site
298654013987	dimerization interface [polypeptide binding]; other site
298654013988	product binding site; other site
298654013989	substrate binding site [chemical binding]; other site
298654013990	zinc binding site [ion binding]; other site
298654013991	catalytic residues [active]
298654013992	Protein of unknown function DUF43; Region: DUF43; pfam01861
298654013993	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654013994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654013995	active site
298654013996	phosphorylation site [posttranslational modification]
298654013997	intermolecular recognition site; other site
298654013998	dimerization interface [polypeptide binding]; other site
298654013999	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654014000	DNA binding site [nucleotide binding]
298654014001	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654014002	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654014003	dimerization interface [polypeptide binding]; other site
298654014004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654014005	dimer interface [polypeptide binding]; other site
298654014006	phosphorylation site [posttranslational modification]
298654014007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654014008	ATP binding site [chemical binding]; other site
298654014009	Mg2+ binding site [ion binding]; other site
298654014010	G-X-G motif; other site
298654014011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654014012	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
298654014013	Coenzyme A binding pocket [chemical binding]; other site
298654014014	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
298654014015	classical (c) SDRs; Region: SDR_c; cd05233
298654014016	NAD(P) binding site [chemical binding]; other site
298654014017	active site
298654014018	tellurite resistance protein terB; Region: terB; cd07176
298654014019	putative metal binding site [ion binding]; other site
298654014020	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654014021	nudix motif; other site
298654014022	EamA-like transporter family; Region: EamA; pfam00892
298654014023	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298654014024	EamA-like transporter family; Region: EamA; pfam00892
298654014025	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
298654014026	Lipase (class 2); Region: Lipase_2; pfam01674
298654014027	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654014028	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654014029	catalytic residue [active]
298654014030	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
298654014031	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654014032	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654014033	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298654014034	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298654014035	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
298654014036	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654014037	ATP binding site [chemical binding]; other site
298654014038	putative Mg++ binding site [ion binding]; other site
298654014039	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654014040	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
298654014041	nucleotide binding region [chemical binding]; other site
298654014042	ATP-binding site [chemical binding]; other site
298654014043	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
298654014044	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
298654014045	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
298654014046	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654014047	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014048	substrate binding site [chemical binding]; other site
298654014049	oxyanion hole (OAH) forming residues; other site
298654014050	trimer interface [polypeptide binding]; other site
298654014051	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
298654014052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654014053	Coenzyme A binding pocket [chemical binding]; other site
298654014054	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654014055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654014056	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654014057	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654014058	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298654014059	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
298654014060	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654014061	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
298654014062	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
298654014063	short chain dehydrogenase; Provisional; Region: PRK07326
298654014064	classical (c) SDRs; Region: SDR_c; cd05233
298654014065	NAD(P) binding site [chemical binding]; other site
298654014066	active site
298654014067	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
298654014068	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
298654014069	DNA binding residues [nucleotide binding]
298654014070	dimer interface [polypeptide binding]; other site
298654014071	[2Fe-2S] cluster binding site [ion binding]; other site
298654014072	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
298654014073	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654014074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654014075	putative substrate translocation pore; other site
298654014076	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
298654014077	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654014078	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
298654014079	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654014080	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654014081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654014082	DNA-binding site [nucleotide binding]; DNA binding site
298654014083	UbiA prenyltransferase family; Region: UbiA; pfam01040
298654014084	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
298654014085	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
298654014086	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
298654014087	NAD binding site [chemical binding]; other site
298654014088	gamma-glutamyl kinase; Provisional; Region: PRK05429
298654014089	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
298654014090	nucleotide binding site [chemical binding]; other site
298654014091	substrate binding site [chemical binding]; other site
298654014092	PUA domain; Region: PUA; pfam01472
298654014093	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654014094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014095	Walker A/P-loop; other site
298654014096	ATP binding site [chemical binding]; other site
298654014097	Q-loop/lid; other site
298654014098	ABC transporter signature motif; other site
298654014099	Walker B; other site
298654014100	D-loop; other site
298654014101	H-loop/switch region; other site
298654014102	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
298654014103	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
298654014104	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
298654014105	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
298654014106	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654014107	active site
298654014108	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014109	MMPL family; Region: MMPL; pfam03176
298654014110	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654014111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654014112	metal binding site [ion binding]; metal-binding site
298654014113	active site
298654014114	I-site; other site
298654014115	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654014116	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654014117	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654014118	active site
298654014119	ATP binding site [chemical binding]; other site
298654014120	substrate binding site [chemical binding]; other site
298654014121	activation loop (A-loop); other site
298654014122	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654014123	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
298654014124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654014125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654014126	metal binding site [ion binding]; metal-binding site
298654014127	active site
298654014128	I-site; other site
298654014129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654014130	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654014131	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014132	short chain dehydrogenase; Provisional; Region: PRK06940
298654014133	classical (c) SDRs; Region: SDR_c; cd05233
298654014134	NAD(P) binding site [chemical binding]; other site
298654014135	active site
298654014136	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654014137	classical (c) SDRs; Region: SDR_c; cd05233
298654014138	NAD(P) binding site [chemical binding]; other site
298654014139	active site
298654014140	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654014141	PAS fold; Region: PAS_4; pfam08448
298654014142	putative active site [active]
298654014143	heme pocket [chemical binding]; other site
298654014144	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654014145	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654014146	metal binding site [ion binding]; metal-binding site
298654014147	active site
298654014148	I-site; other site
298654014149	PAS domain; Region: PAS; smart00091
298654014150	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654014151	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654014152	metal binding site [ion binding]; metal-binding site
298654014153	active site
298654014154	I-site; other site
298654014155	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654014156	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654014157	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654014158	NAD(P) binding site [chemical binding]; other site
298654014159	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654014160	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
298654014161	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
298654014162	catalytic Zn binding site [ion binding]; other site
298654014163	NAD binding site [chemical binding]; other site
298654014164	structural Zn binding site [ion binding]; other site
298654014165	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654014166	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654014167	DNA-binding site [nucleotide binding]; DNA binding site
298654014168	FCD domain; Region: FCD; pfam07729
298654014169	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654014170	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654014171	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014172	substrate binding site [chemical binding]; other site
298654014173	oxyanion hole (OAH) forming residues; other site
298654014174	trimer interface [polypeptide binding]; other site
298654014175	acyl-CoA synthetase; Validated; Region: PRK07798
298654014176	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014177	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014178	acyl-activating enzyme (AAE) consensus motif; other site
298654014179	acyl-activating enzyme (AAE) consensus motif; other site
298654014180	AMP binding site [chemical binding]; other site
298654014181	active site
298654014182	CoA binding site [chemical binding]; other site
298654014183	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654014184	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014185	substrate binding site [chemical binding]; other site
298654014186	oxyanion hole (OAH) forming residues; other site
298654014187	trimer interface [polypeptide binding]; other site
298654014188	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014189	active site
298654014190	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014191	active site
298654014192	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
298654014193	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014194	active site
298654014195	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
298654014196	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654014197	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014198	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014199	acyl-activating enzyme (AAE) consensus motif; other site
298654014200	AMP binding site [chemical binding]; other site
298654014201	active site
298654014202	CoA binding site [chemical binding]; other site
298654014203	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654014204	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014205	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014206	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014207	acyl-activating enzyme (AAE) consensus motif; other site
298654014208	acyl-activating enzyme (AAE) consensus motif; other site
298654014209	AMP binding site [chemical binding]; other site
298654014210	active site
298654014211	CoA binding site [chemical binding]; other site
298654014212	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654014213	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014214	substrate binding site [chemical binding]; other site
298654014215	oxyanion hole (OAH) forming residues; other site
298654014216	trimer interface [polypeptide binding]; other site
298654014217	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
298654014218	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014219	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654014220	acyl-activating enzyme (AAE) consensus motif; other site
298654014221	acyl-activating enzyme (AAE) consensus motif; other site
298654014222	putative AMP binding site [chemical binding]; other site
298654014223	putative active site [active]
298654014224	putative CoA binding site [chemical binding]; other site
298654014225	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654014226	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014227	substrate binding site [chemical binding]; other site
298654014228	oxyanion hole (OAH) forming residues; other site
298654014229	trimer interface [polypeptide binding]; other site
298654014230	enoyl-CoA hydratase; Provisional; Region: PRK06144
298654014231	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014232	substrate binding site [chemical binding]; other site
298654014233	oxyanion hole (OAH) forming residues; other site
298654014234	trimer interface [polypeptide binding]; other site
298654014235	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654014236	MarR family; Region: MarR; pfam01047
298654014237	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654014238	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
298654014239	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654014240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654014241	DNA binding residues [nucleotide binding]
298654014242	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
298654014243	oxidoreductase; Provisional; Region: PRK06196
298654014244	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
298654014245	putative NAD(P) binding site [chemical binding]; other site
298654014246	active site
298654014247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654014248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014249	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
298654014250	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
298654014251	putative active site [active]
298654014252	putative dimer interface [polypeptide binding]; other site
298654014253	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654014254	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654014255	catalytic residue [active]
298654014256	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
298654014257	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
298654014258	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654014259	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654014260	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
298654014261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654014262	Cytochrome P450; Region: p450; cl12078
298654014263	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654014264	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
298654014265	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
298654014266	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654014267	Nitronate monooxygenase; Region: NMO; pfam03060
298654014268	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
298654014269	FMN binding site [chemical binding]; other site
298654014270	substrate binding site [chemical binding]; other site
298654014271	putative catalytic residue [active]
298654014272	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298654014273	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298654014274	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
298654014275	hypothetical protein; Provisional; Region: PRK10621
298654014276	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298654014277	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
298654014278	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654014279	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654014280	active site
298654014281	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
298654014282	adenosine deaminase; Provisional; Region: PRK09358
298654014283	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298654014284	active site
298654014285	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014286	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
298654014287	active site
298654014288	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
298654014289	putative active site [active]
298654014290	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
298654014291	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654014292	Cytochrome P450; Region: p450; cl12078
298654014293	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654014294	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654014295	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
298654014296	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654014297	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654014298	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654014299	NAD binding site [chemical binding]; other site
298654014300	catalytic residues [active]
298654014301	EthD domain; Region: EthD; cl17553
298654014302	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
298654014303	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654014304	NAD binding site [chemical binding]; other site
298654014305	catalytic Zn binding site [ion binding]; other site
298654014306	substrate binding site [chemical binding]; other site
298654014307	structural Zn binding site [ion binding]; other site
298654014308	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654014309	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654014310	NAD(P) binding site [chemical binding]; other site
298654014311	active site
298654014312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654014313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014314	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
298654014315	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654014316	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654014317	phosphopeptide binding site; other site
298654014318	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
298654014319	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
298654014320	Walker A/P-loop; other site
298654014321	ATP binding site [chemical binding]; other site
298654014322	Q-loop/lid; other site
298654014323	ABC transporter signature motif; other site
298654014324	Walker B; other site
298654014325	D-loop; other site
298654014326	H-loop/switch region; other site
298654014327	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654014328	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298654014329	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
298654014330	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
298654014331	putative dimer interface [polypeptide binding]; other site
298654014332	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298654014333	putative catalytic site [active]
298654014334	putative metal binding site [ion binding]; other site
298654014335	putative phosphate binding site [ion binding]; other site
298654014336	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
298654014337	dinuclear metal binding motif [ion binding]; other site
298654014338	enoyl-CoA hydratase; Provisional; Region: PRK06142
298654014339	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014340	substrate binding site [chemical binding]; other site
298654014341	oxyanion hole (OAH) forming residues; other site
298654014342	trimer interface [polypeptide binding]; other site
298654014343	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
298654014344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654014345	dimerization interface [polypeptide binding]; other site
298654014346	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654014347	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654014348	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654014349	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014350	Walker A/P-loop; other site
298654014351	ATP binding site [chemical binding]; other site
298654014352	Q-loop/lid; other site
298654014353	ABC transporter signature motif; other site
298654014354	Walker B; other site
298654014355	D-loop; other site
298654014356	H-loop/switch region; other site
298654014357	peptide synthase; Provisional; Region: PRK12316
298654014358	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654014359	active site
298654014360	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
298654014361	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
298654014362	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298654014363	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
298654014364	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654014365	active site
298654014366	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
298654014367	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
298654014368	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
298654014369	catalytic residues [active]
298654014370	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
298654014371	Domain of unknown function DUF20; Region: UPF0118; pfam01594
298654014372	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
298654014373	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
298654014374	Zn binding site [ion binding]; other site
298654014375	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654014376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654014377	putative substrate translocation pore; other site
298654014378	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654014379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654014380	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
298654014381	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654014382	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298654014383	dimerization interface [polypeptide binding]; other site
298654014384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654014385	dimer interface [polypeptide binding]; other site
298654014386	phosphorylation site [posttranslational modification]
298654014387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654014388	ATP binding site [chemical binding]; other site
298654014389	Mg2+ binding site [ion binding]; other site
298654014390	G-X-G motif; other site
298654014391	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654014392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654014393	active site
298654014394	phosphorylation site [posttranslational modification]
298654014395	intermolecular recognition site; other site
298654014396	dimerization interface [polypeptide binding]; other site
298654014397	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654014398	DNA binding site [nucleotide binding]
298654014399	Mechanosensitive ion channel; Region: MS_channel; pfam00924
298654014400	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
298654014401	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654014402	active site
298654014403	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654014404	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654014405	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654014406	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
298654014407	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
298654014408	active site
298654014409	catalytic site [active]
298654014410	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
298654014411	apolar tunnel; other site
298654014412	heme binding site [chemical binding]; other site
298654014413	dimerization interface [polypeptide binding]; other site
298654014414	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654014415	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654014416	putative substrate translocation pore; other site
298654014417	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654014418	putative DNA binding site [nucleotide binding]; other site
298654014419	putative Zn2+ binding site [ion binding]; other site
298654014420	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
298654014421	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654014422	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654014423	ABC transporter; Region: ABC_tran_2; pfam12848
298654014424	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298654014425	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
298654014426	AAA domain; Region: AAA_18; pfam13238
298654014427	active site
298654014428	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014429	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654014430	Walker A/P-loop; other site
298654014431	ATP binding site [chemical binding]; other site
298654014432	Q-loop/lid; other site
298654014433	ABC transporter signature motif; other site
298654014434	Walker B; other site
298654014435	D-loop; other site
298654014436	H-loop/switch region; other site
298654014437	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654014438	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
298654014439	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
298654014440	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654014441	Archaeal ATPase; Region: Arch_ATPase; pfam01637
298654014442	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654014443	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654014444	Cupin domain; Region: Cupin_2; cl17218
298654014445	Helix-turn-helix domain; Region: HTH_18; pfam12833
298654014446	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654014447	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
298654014448	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
298654014449	dimer interface [polypeptide binding]; other site
298654014450	active site
298654014451	glycine-pyridoxal phosphate binding site [chemical binding]; other site
298654014452	folate binding site [chemical binding]; other site
298654014453	TAP-like protein; Region: Abhydrolase_4; pfam08386
298654014454	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
298654014455	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298654014456	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298654014457	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298654014458	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
298654014459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654014460	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298654014461	dimerization interface [polypeptide binding]; other site
298654014462	LysE type translocator; Region: LysE; cl00565
298654014463	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
298654014464	homodimer interface [polypeptide binding]; other site
298654014465	homotetramer interface [polypeptide binding]; other site
298654014466	active site pocket [active]
298654014467	cleavage site
298654014468	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654014469	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
298654014470	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
298654014471	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
298654014472	putative NADH binding site [chemical binding]; other site
298654014473	putative active site [active]
298654014474	nudix motif; other site
298654014475	putative metal binding site [ion binding]; other site
298654014476	Maf-like protein; Region: Maf; pfam02545
298654014477	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
298654014478	active site
298654014479	dimer interface [polypeptide binding]; other site
298654014480	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
298654014481	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
298654014482	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298654014483	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
298654014484	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
298654014485	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
298654014486	active site
298654014487	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
298654014488	domain_subunit interface; other site
298654014489	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
298654014490	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
298654014491	active site
298654014492	FMN binding site [chemical binding]; other site
298654014493	substrate binding site [chemical binding]; other site
298654014494	3Fe-4S cluster binding site [ion binding]; other site
298654014495	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
298654014496	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
298654014497	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654014498	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654014499	non-specific DNA binding site [nucleotide binding]; other site
298654014500	salt bridge; other site
298654014501	sequence-specific DNA binding site [nucleotide binding]; other site
298654014502	Cupin domain; Region: Cupin_2; pfam07883
298654014503	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
298654014504	FMN binding site [chemical binding]; other site
298654014505	dimer interface [polypeptide binding]; other site
298654014506	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014507	AAA domain; Region: AAA_23; pfam13476
298654014508	Walker A/P-loop; other site
298654014509	ATP binding site [chemical binding]; other site
298654014510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014511	ABC transporter signature motif; other site
298654014512	Walker B; other site
298654014513	D-loop; other site
298654014514	H-loop/switch region; other site
298654014515	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
298654014516	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654014517	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654014518	putative metal binding site [ion binding]; other site
298654014519	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
298654014520	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565
298654014521	putative metal binding site [ion binding]; other site
298654014522	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
298654014523	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
298654014524	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654014525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654014526	active site
298654014527	phosphorylation site [posttranslational modification]
298654014528	intermolecular recognition site; other site
298654014529	dimerization interface [polypeptide binding]; other site
298654014530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654014531	DNA binding site [nucleotide binding]
298654014532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654014533	dimer interface [polypeptide binding]; other site
298654014534	phosphorylation site [posttranslational modification]
298654014535	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654014536	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654014537	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654014538	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654014539	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
298654014540	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654014541	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654014542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
298654014543	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654014544	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
298654014545	active site
298654014546	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654014547	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
298654014548	active site
298654014549	catalytic tetrad [active]
298654014550	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
298654014551	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654014552	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654014553	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654014554	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654014555	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298654014556	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298654014557	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
298654014558	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
298654014559	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
298654014560	Walker A/P-loop; other site
298654014561	ATP binding site [chemical binding]; other site
298654014562	Q-loop/lid; other site
298654014563	ABC transporter signature motif; other site
298654014564	Walker B; other site
298654014565	D-loop; other site
298654014566	H-loop/switch region; other site
298654014567	TOBE domain; Region: TOBE_2; pfam08402
298654014568	Predicted membrane protein [Function unknown]; Region: COG4280
298654014569	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654014570	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654014571	active site
298654014572	catalytic tetrad [active]
298654014573	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
298654014574	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
298654014575	dimer interface [polypeptide binding]; other site
298654014576	ssDNA binding site [nucleotide binding]; other site
298654014577	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298654014578	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
298654014579	catalytic residues [active]
298654014580	dimer interface [polypeptide binding]; other site
298654014581	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
298654014582	active site
298654014583	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654014584	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654014585	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
298654014586	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
298654014587	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298654014588	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654014589	ligand binding site [chemical binding]; other site
298654014590	flexible hinge region; other site
298654014591	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
298654014592	Pirin-related protein [General function prediction only]; Region: COG1741
298654014593	Pirin; Region: Pirin; pfam02678
298654014594	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
298654014595	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
298654014596	catalytic site [active]
298654014597	putative active site [active]
298654014598	putative substrate binding site [chemical binding]; other site
298654014599	dimer interface [polypeptide binding]; other site
298654014600	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
298654014601	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654014602	hydrophobic ligand binding site; other site
298654014603	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
298654014604	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298654014605	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
298654014606	substrate binding site [chemical binding]; other site
298654014607	dimer interface [polypeptide binding]; other site
298654014608	ATP binding site [chemical binding]; other site
298654014609	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654014610	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654014611	NAD(P) binding site [chemical binding]; other site
298654014612	catalytic residues [active]
298654014613	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654014614	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654014615	active site
298654014616	phosphorylation site [posttranslational modification]
298654014617	intermolecular recognition site; other site
298654014618	dimerization interface [polypeptide binding]; other site
298654014619	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654014620	DNA binding residues [nucleotide binding]
298654014621	dimerization interface [polypeptide binding]; other site
298654014622	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
298654014623	homotrimer interface [polypeptide binding]; other site
298654014624	Walker A motif; other site
298654014625	GTP binding site [chemical binding]; other site
298654014626	Walker B motif; other site
298654014627	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
298654014628	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
298654014629	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
298654014630	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
298654014631	putative dimer interface [polypeptide binding]; other site
298654014632	active site pocket [active]
298654014633	putative cataytic base [active]
298654014634	adenylate kinase; Provisional; Region: PRK13808
298654014635	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298654014636	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298654014637	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298654014638	active site
298654014639	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654014640	catalytic triad [active]
298654014641	dimer interface [polypeptide binding]; other site
298654014642	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654014643	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654014644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
298654014645	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
298654014646	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
298654014647	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
298654014648	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
298654014649	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
298654014650	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
298654014651	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
298654014652	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
298654014653	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
298654014654	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654014655	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014656	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
298654014657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014658	Walker A/P-loop; other site
298654014659	ATP binding site [chemical binding]; other site
298654014660	Q-loop/lid; other site
298654014661	ABC transporter signature motif; other site
298654014662	Walker B; other site
298654014663	D-loop; other site
298654014664	H-loop/switch region; other site
298654014665	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654014666	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654014667	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014668	substrate binding site [chemical binding]; other site
298654014669	oxyanion hole (OAH) forming residues; other site
298654014670	trimer interface [polypeptide binding]; other site
298654014671	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654014672	Uncharacterized conserved protein [Function unknown]; Region: COG4278
298654014673	Phosphotransferase enzyme family; Region: APH; pfam01636
298654014674	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298654014675	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014676	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654014677	substrate binding site [chemical binding]; other site
298654014678	oxyanion hole (OAH) forming residues; other site
298654014679	trimer interface [polypeptide binding]; other site
298654014680	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014681	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654014682	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654014683	active site
298654014684	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
298654014685	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654014686	Helix-turn-helix domain; Region: HTH_17; cl17695
298654014687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654014688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014689	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
298654014690	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654014691	NAD binding site [chemical binding]; other site
298654014692	catalytic Zn binding site [ion binding]; other site
298654014693	substrate binding site [chemical binding]; other site
298654014694	structural Zn binding site [ion binding]; other site
298654014695	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654014696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654014697	active site
298654014698	phosphorylation site [posttranslational modification]
298654014699	intermolecular recognition site; other site
298654014700	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654014701	DNA binding residues [nucleotide binding]
298654014702	dimerization interface [polypeptide binding]; other site
298654014703	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654014704	Histidine kinase; Region: HisKA_3; pfam07730
298654014705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654014706	ATP binding site [chemical binding]; other site
298654014707	Mg2+ binding site [ion binding]; other site
298654014708	G-X-G motif; other site
298654014709	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654014710	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014711	AMP binding site [chemical binding]; other site
298654014712	active site
298654014713	acyl-activating enzyme (AAE) consensus motif; other site
298654014714	CoA binding site [chemical binding]; other site
298654014715	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654014716	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014717	substrate binding site [chemical binding]; other site
298654014718	oxyanion hole (OAH) forming residues; other site
298654014719	trimer interface [polypeptide binding]; other site
298654014720	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
298654014721	active site
298654014722	catalytic residues [active]
298654014723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654014724	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654014725	NAD(P) binding site [chemical binding]; other site
298654014726	active site
298654014727	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
298654014728	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654014729	dimer interface [polypeptide binding]; other site
298654014730	active site
298654014731	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
298654014732	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
298654014733	acyl-activating enzyme (AAE) consensus motif; other site
298654014734	putative AMP binding site [chemical binding]; other site
298654014735	putative active site [active]
298654014736	putative CoA binding site [chemical binding]; other site
298654014737	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654014738	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654014739	DNA-binding site [nucleotide binding]; DNA binding site
298654014740	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654014741	TM-ABC transporter signature motif; other site
298654014742	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654014743	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654014744	TM-ABC transporter signature motif; other site
298654014745	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654014746	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654014747	Walker A/P-loop; other site
298654014748	ATP binding site [chemical binding]; other site
298654014749	Q-loop/lid; other site
298654014750	ABC transporter signature motif; other site
298654014751	Walker B; other site
298654014752	D-loop; other site
298654014753	H-loop/switch region; other site
298654014754	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654014755	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654014756	Walker A/P-loop; other site
298654014757	ATP binding site [chemical binding]; other site
298654014758	Q-loop/lid; other site
298654014759	ABC transporter signature motif; other site
298654014760	Walker B; other site
298654014761	D-loop; other site
298654014762	H-loop/switch region; other site
298654014763	thiolase; Provisional; Region: PRK06158
298654014764	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654014765	active site
298654014766	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
298654014767	active site
298654014768	catalytic site [active]
298654014769	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654014770	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654014771	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654014772	active site 1 [active]
298654014773	active site 2 [active]
298654014774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654014775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014776	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
298654014777	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
298654014778	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654014779	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014780	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654014781	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654014782	putative ligand binding site [chemical binding]; other site
298654014783	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
298654014785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654014786	Coenzyme A binding pocket [chemical binding]; other site
298654014787	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
298654014788	CoA binding domain; Region: CoA_binding_2; pfam13380
298654014789	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
298654014790	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
298654014791	enoyl-CoA hydratase; Provisional; Region: PRK08140
298654014792	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014793	substrate binding site [chemical binding]; other site
298654014794	oxyanion hole (OAH) forming residues; other site
298654014795	trimer interface [polypeptide binding]; other site
298654014796	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654014797	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654014798	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014799	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654014800	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
298654014801	FAD binding site [chemical binding]; other site
298654014802	substrate binding site [chemical binding]; other site
298654014803	catalytic base [active]
298654014804	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654014805	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
298654014806	active site
298654014807	catalytic site [active]
298654014808	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654014809	active site 2 [active]
298654014810	active site 1 [active]
298654014811	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654014812	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014813	substrate binding site [chemical binding]; other site
298654014814	oxyanion hole (OAH) forming residues; other site
298654014815	trimer interface [polypeptide binding]; other site
298654014816	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014817	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654014818	active site
298654014819	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654014820	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014821	substrate binding site [chemical binding]; other site
298654014822	oxyanion hole (OAH) forming residues; other site
298654014823	trimer interface [polypeptide binding]; other site
298654014824	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654014825	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014826	substrate binding site [chemical binding]; other site
298654014827	oxyanion hole (OAH) forming residues; other site
298654014828	trimer interface [polypeptide binding]; other site
298654014829	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014830	AMP-binding enzyme; Region: AMP-binding; pfam00501
298654014831	acyl-activating enzyme (AAE) consensus motif; other site
298654014832	AMP binding site [chemical binding]; other site
298654014833	active site
298654014834	CoA binding site [chemical binding]; other site
298654014835	PhoD-like phosphatase; Region: PhoD; pfam09423
298654014836	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
298654014837	putative active site [active]
298654014838	putative metal binding site [ion binding]; other site
298654014839	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654014840	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654014841	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654014842	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654014843	putative ligand binding site [chemical binding]; other site
298654014844	lipid-transfer protein; Provisional; Region: PRK08256
298654014845	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654014846	active site
298654014847	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654014848	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654014849	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
298654014850	iron-sulfur cluster [ion binding]; other site
298654014851	[2Fe-2S] cluster binding site [ion binding]; other site
298654014852	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298654014853	classical (c) SDRs; Region: SDR_c; cd05233
298654014854	NAD(P) binding site [chemical binding]; other site
298654014855	active site
298654014856	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654014857	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654014858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654014859	Walker A/P-loop; other site
298654014860	ATP binding site [chemical binding]; other site
298654014861	Q-loop/lid; other site
298654014862	ABC transporter signature motif; other site
298654014863	Walker B; other site
298654014864	D-loop; other site
298654014865	H-loop/switch region; other site
298654014866	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654014867	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654014868	TM-ABC transporter signature motif; other site
298654014869	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654014870	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654014871	TM-ABC transporter signature motif; other site
298654014872	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654014873	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654014874	Walker A/P-loop; other site
298654014875	ATP binding site [chemical binding]; other site
298654014876	Q-loop/lid; other site
298654014877	ABC transporter signature motif; other site
298654014878	Walker B; other site
298654014879	D-loop; other site
298654014880	H-loop/switch region; other site
298654014881	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654014882	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654014883	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654014884	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654014886	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654014887	NAD(P) binding site [chemical binding]; other site
298654014888	active site
298654014889	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654014890	non-specific DNA binding site [nucleotide binding]; other site
298654014891	salt bridge; other site
298654014892	sequence-specific DNA binding site [nucleotide binding]; other site
298654014893	HipA N-terminal domain; Region: Couple_hipA; cl11853
298654014894	HipA-like N-terminal domain; Region: HipA_N; pfam07805
298654014895	HipA-like C-terminal domain; Region: HipA_C; pfam07804
298654014896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654014897	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
298654014898	NAD(P) binding site [chemical binding]; other site
298654014899	active site
298654014900	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654014901	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654014902	active site
298654014903	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654014904	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014905	active site
298654014906	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654014907	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654014908	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014909	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654014910	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014911	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654014912	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014913	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014914	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
298654014915	acyl-activating enzyme (AAE) consensus motif; other site
298654014916	AMP binding site [chemical binding]; other site
298654014917	active site
298654014918	CoA binding site [chemical binding]; other site
298654014919	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654014920	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654014921	substrate binding site [chemical binding]; other site
298654014922	oxyanion hole (OAH) forming residues; other site
298654014923	trimer interface [polypeptide binding]; other site
298654014924	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298654014925	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654014926	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654014927	NAD binding site [chemical binding]; other site
298654014928	catalytic residues [active]
298654014929	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654014930	Cytochrome P450; Region: p450; cl12078
298654014931	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
298654014932	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
298654014933	DNA binding residues [nucleotide binding]
298654014934	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654014935	drug binding residues [chemical binding]; other site
298654014936	dimer interface [polypeptide binding]; other site
298654014937	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
298654014938	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654014939	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654014940	NAD(P) binding site [chemical binding]; other site
298654014941	active site
298654014942	metal binding site [ion binding]; metal-binding site
298654014943	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
298654014944	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
298654014945	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654014946	lipid-transfer protein; Provisional; Region: PRK07855
298654014947	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654014948	active site
298654014949	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654014950	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654014951	active site
298654014952	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654014953	putative active site [active]
298654014954	putative substrate binding site [chemical binding]; other site
298654014955	ATP binding site [chemical binding]; other site
298654014956	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654014957	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654014958	DNA-binding site [nucleotide binding]; DNA binding site
298654014959	FCD domain; Region: FCD; pfam07729
298654014960	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014961	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
298654014962	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014963	acyl-activating enzyme (AAE) consensus motif; other site
298654014964	AMP binding site [chemical binding]; other site
298654014965	active site
298654014966	CoA binding site [chemical binding]; other site
298654014967	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654014968	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
298654014969	NAD(P) binding site [chemical binding]; other site
298654014970	catalytic residues [active]
298654014971	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654014972	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654014973	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654014974	classical (c) SDRs; Region: SDR_c; cd05233
298654014975	NAD(P) binding site [chemical binding]; other site
298654014976	active site
298654014977	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
298654014978	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654014979	substrate binding pocket [chemical binding]; other site
298654014980	catalytic triad [active]
298654014981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654014982	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654014983	NAD(P) binding site [chemical binding]; other site
298654014984	active site
298654014985	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654014986	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654014987	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654014988	acyl-CoA synthetase; Validated; Region: PRK06145
298654014989	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654014990	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654014991	acyl-activating enzyme (AAE) consensus motif; other site
298654014992	putative AMP binding site [chemical binding]; other site
298654014993	putative active site [active]
298654014994	putative CoA binding site [chemical binding]; other site
298654014995	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654014996	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654014997	Cytochrome P450; Region: p450; cl12078
298654014998	Putative cyclase; Region: Cyclase; pfam04199
298654014999	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015000	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015001	short chain dehydrogenase; Validated; Region: PRK07069
298654015002	classical (c) SDRs; Region: SDR_c; cd05233
298654015003	NAD(P) binding site [chemical binding]; other site
298654015004	active site
298654015005	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015006	classical (c) SDRs; Region: SDR_c; cd05233
298654015007	NAD(P) binding site [chemical binding]; other site
298654015008	active site
298654015009	enoyl-CoA hydratase; Provisional; Region: PRK08252
298654015010	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015011	substrate binding site [chemical binding]; other site
298654015012	oxyanion hole (OAH) forming residues; other site
298654015013	trimer interface [polypeptide binding]; other site
298654015014	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654015015	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
298654015016	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015017	Cytochrome P450; Region: p450; cl12078
298654015018	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
298654015019	tetramer interface [polypeptide binding]; other site
298654015020	TPP-binding site [chemical binding]; other site
298654015021	heterodimer interface [polypeptide binding]; other site
298654015022	phosphorylation loop region [posttranslational modification]
298654015023	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
298654015024	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
298654015025	alpha subunit interface [polypeptide binding]; other site
298654015026	TPP binding site [chemical binding]; other site
298654015027	heterodimer interface [polypeptide binding]; other site
298654015028	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654015029	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015030	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015031	active site
298654015032	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015033	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015034	MarR family; Region: MarR; pfam01047
298654015035	3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370
298654015036	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
298654015037	active site
298654015038	metal binding site [ion binding]; metal-binding site
298654015039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015041	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
298654015042	active site
298654015043	catalytic triad [active]
298654015044	oxyanion hole [active]
298654015045	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015046	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015047	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298654015048	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654015049	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654015050	NAD(P) binding site [chemical binding]; other site
298654015051	EthD domain; Region: EthD; pfam07110
298654015052	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015053	AMP-binding enzyme; Region: AMP-binding; pfam00501
298654015054	acyl-activating enzyme (AAE) consensus motif; other site
298654015055	AMP binding site [chemical binding]; other site
298654015056	active site
298654015057	CoA binding site [chemical binding]; other site
298654015058	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298654015059	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
298654015060	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
298654015061	putative NAD(P) binding site [chemical binding]; other site
298654015062	active site
298654015063	putative substrate binding site [chemical binding]; other site
298654015064	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
298654015065	NB-ARC domain; Region: NB-ARC; pfam00931
298654015066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654015067	dimerization interface [polypeptide binding]; other site
298654015068	putative DNA binding site [nucleotide binding]; other site
298654015069	putative Zn2+ binding site [ion binding]; other site
298654015070	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654015071	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654015072	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
298654015073	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
298654015074	FAD binding domain; Region: FAD_binding_2; pfam00890
298654015075	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
298654015076	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298654015077	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298654015078	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
298654015079	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
298654015080	active site
298654015081	catalytic residues [active]
298654015082	metal binding site [ion binding]; metal-binding site
298654015083	DmpG-like communication domain; Region: DmpG_comm; pfam07836
298654015084	acetaldehyde dehydrogenase; Validated; Region: PRK08300
298654015085	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298654015086	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
298654015087	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
298654015088	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
298654015089	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
298654015090	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654015091	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654015092	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015093	acyl-activating enzyme (AAE) consensus motif; other site
298654015094	AMP binding site [chemical binding]; other site
298654015095	active site
298654015096	CoA binding site [chemical binding]; other site
298654015097	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015098	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654015099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015100	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654015101	NAD(P) binding site [chemical binding]; other site
298654015102	active site
298654015103	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015104	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015105	NAD(P) binding site [chemical binding]; other site
298654015106	active site
298654015107	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654015108	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654015109	hypothetical protein; Provisional; Region: PRK06446
298654015110	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654015111	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654015112	[2Fe-2S] cluster binding site [ion binding]; other site
298654015113	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654015114	alpha subunit interface [polypeptide binding]; other site
298654015115	active site
298654015116	substrate binding site [chemical binding]; other site
298654015117	Fe binding site [ion binding]; other site
298654015118	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015119	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015120	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
298654015121	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015122	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
298654015123	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654015124	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654015125	NAD binding site [chemical binding]; other site
298654015126	catalytic residues [active]
298654015127	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015128	Cytochrome P450; Region: p450; cl12078
298654015129	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654015130	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
298654015131	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654015132	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015133	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015134	Cytochrome P450; Region: p450; cl12078
298654015135	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015136	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015137	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654015138	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654015139	classical (c) SDRs; Region: SDR_c; cd05233
298654015140	NAD(P) binding site [chemical binding]; other site
298654015141	active site
298654015142	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015143	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654015144	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654015145	active site
298654015146	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015147	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015148	active site
298654015149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654015150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654015151	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015152	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015153	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654015154	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654015155	NAD(P) binding site [chemical binding]; other site
298654015156	active site
298654015157	metal binding site [ion binding]; metal-binding site
298654015158	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654015159	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
298654015160	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015161	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015162	active site
298654015163	Phosphotransferase enzyme family; Region: APH; pfam01636
298654015164	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654015165	putative active site [active]
298654015166	putative substrate binding site [chemical binding]; other site
298654015167	ATP binding site [chemical binding]; other site
298654015168	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654015169	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
298654015170	NAD(P) binding site [chemical binding]; other site
298654015171	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015172	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654015173	putative ligand binding site [chemical binding]; other site
298654015174	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015175	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654015176	putative ligand binding site [chemical binding]; other site
298654015177	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015178	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015179	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
298654015180	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015181	active site
298654015182	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015183	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015184	active site
298654015185	enoyl-CoA hydratase; Provisional; Region: PRK08290
298654015186	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015187	substrate binding site [chemical binding]; other site
298654015188	oxyanion hole (OAH) forming residues; other site
298654015189	trimer interface [polypeptide binding]; other site
298654015190	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015191	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015192	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015193	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015194	active site
298654015195	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654015196	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298654015197	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
298654015198	active site
298654015199	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654015200	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
298654015201	NAD(P) binding site [chemical binding]; other site
298654015202	catalytic residues [active]
298654015203	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
298654015204	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
298654015205	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654015206	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654015207	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015208	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015209	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015210	active site
298654015211	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654015212	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015213	substrate binding site [chemical binding]; other site
298654015214	oxyanion hole (OAH) forming residues; other site
298654015215	trimer interface [polypeptide binding]; other site
298654015216	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015217	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015218	active site
298654015219	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015220	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015221	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
298654015222	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015223	acyl-activating enzyme (AAE) consensus motif; other site
298654015224	AMP binding site [chemical binding]; other site
298654015225	active site
298654015226	CoA binding site [chemical binding]; other site
298654015227	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
298654015228	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
298654015229	FAD binding pocket [chemical binding]; other site
298654015230	FAD binding motif [chemical binding]; other site
298654015231	phosphate binding motif [ion binding]; other site
298654015232	beta-alpha-beta structure motif; other site
298654015233	NAD(p) ribose binding residues [chemical binding]; other site
298654015234	NAD binding pocket [chemical binding]; other site
298654015235	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
298654015236	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654015237	catalytic loop [active]
298654015238	iron binding site [ion binding]; other site
298654015239	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015240	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015241	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654015242	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015243	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
298654015244	B12 binding site [chemical binding]; other site
298654015245	cobalt ligand [ion binding]; other site
298654015246	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
298654015247	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
298654015248	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015249	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
298654015250	acyl-activating enzyme (AAE) consensus motif; other site
298654015251	acyl-activating enzyme (AAE) consensus motif; other site
298654015252	putative AMP binding site [chemical binding]; other site
298654015253	putative active site [active]
298654015254	putative CoA binding site [chemical binding]; other site
298654015255	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015256	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654015257	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015258	acyl-activating enzyme (AAE) consensus motif; other site
298654015259	AMP binding site [chemical binding]; other site
298654015260	active site
298654015261	CoA binding site [chemical binding]; other site
298654015262	enoyl-CoA hydratase; Provisional; Region: PRK06688
298654015263	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015264	substrate binding site [chemical binding]; other site
298654015265	oxyanion hole (OAH) forming residues; other site
298654015266	trimer interface [polypeptide binding]; other site
298654015267	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015268	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015269	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
298654015270	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
298654015271	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
298654015272	NAD binding site [chemical binding]; other site
298654015273	catalytic residues [active]
298654015274	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015275	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654015276	TM-ABC transporter signature motif; other site
298654015277	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654015278	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654015279	TM-ABC transporter signature motif; other site
298654015280	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654015281	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654015282	Walker A/P-loop; other site
298654015283	ATP binding site [chemical binding]; other site
298654015284	Q-loop/lid; other site
298654015285	ABC transporter signature motif; other site
298654015286	Walker B; other site
298654015287	D-loop; other site
298654015288	H-loop/switch region; other site
298654015289	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654015290	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654015291	Walker A/P-loop; other site
298654015292	ATP binding site [chemical binding]; other site
298654015293	Q-loop/lid; other site
298654015294	ABC transporter signature motif; other site
298654015295	Walker B; other site
298654015296	D-loop; other site
298654015297	H-loop/switch region; other site
298654015298	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654015299	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015300	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654015301	sequence-specific DNA binding site [nucleotide binding]; other site
298654015302	salt bridge; other site
298654015303	Domain of unknown function (DUF955); Region: DUF955; pfam06114
298654015304	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
298654015305	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654015306	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654015307	DNA-binding site [nucleotide binding]; DNA binding site
298654015308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015309	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654015310	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654015311	active site
298654015312	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015313	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015314	active site
298654015315	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
298654015316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015317	NAD(P) binding site [chemical binding]; other site
298654015318	active site
298654015319	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015320	Cytochrome P450; Region: p450; cl12078
298654015321	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654015322	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654015323	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654015324	lipid-transfer protein; Provisional; Region: PRK07855
298654015325	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654015326	active site
298654015327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015328	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015329	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
298654015330	classical (c) SDRs; Region: SDR_c; cd05233
298654015331	NAD(P) binding site [chemical binding]; other site
298654015332	active site
298654015333	putative acyltransferase; Provisional; Region: PRK05790
298654015334	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654015335	dimer interface [polypeptide binding]; other site
298654015336	active site
298654015337	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
298654015338	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298654015339	active site
298654015340	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654015341	catalytic triad [active]
298654015342	dimer interface [polypeptide binding]; other site
298654015343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015344	active site
298654015345	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015346	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654015347	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015348	Cytochrome P450; Region: p450; cl12078
298654015349	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
298654015350	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654015351	active site
298654015352	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654015353	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654015354	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
298654015355	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654015356	dimer interface [polypeptide binding]; other site
298654015357	active site
298654015358	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
298654015359	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654015360	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015361	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015362	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654015363	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015364	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654015365	putative AMP binding site [chemical binding]; other site
298654015366	putative active site [active]
298654015367	acyl-activating enzyme (AAE) consensus motif; other site
298654015368	putative CoA binding site [chemical binding]; other site
298654015369	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654015370	classical (c) SDRs; Region: SDR_c; cd05233
298654015371	NAD(P) binding site [chemical binding]; other site
298654015372	active site
298654015373	lipid-transfer protein; Provisional; Region: PRK07855
298654015374	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654015375	active site
298654015376	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654015377	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654015378	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654015379	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015380	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015381	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015382	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015383	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015384	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654015385	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015386	active site
298654015387	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015388	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015389	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
298654015390	short chain dehydrogenase; Provisional; Region: PRK07791
298654015391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015392	NAD(P) binding site [chemical binding]; other site
298654015393	active site
298654015394	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654015395	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015396	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015397	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015398	putative acyltransferase; Provisional; Region: PRK05790
298654015399	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654015400	dimer interface [polypeptide binding]; other site
298654015401	active site
298654015402	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015403	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654015404	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654015405	Walker A/P-loop; other site
298654015406	ATP binding site [chemical binding]; other site
298654015407	Q-loop/lid; other site
298654015408	ABC transporter signature motif; other site
298654015409	Walker B; other site
298654015410	D-loop; other site
298654015411	H-loop/switch region; other site
298654015412	EthD domain; Region: EthD; cl17553
298654015413	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
298654015414	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
298654015415	dimer interface [polypeptide binding]; other site
298654015416	PYR/PP interface [polypeptide binding]; other site
298654015417	TPP binding site [chemical binding]; other site
298654015418	substrate binding site [chemical binding]; other site
298654015419	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
298654015420	TPP-binding site [chemical binding]; other site
298654015421	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
298654015422	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298654015423	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015425	active site
298654015426	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
298654015427	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
298654015428	NAD binding site [chemical binding]; other site
298654015429	catalytic Zn binding site [ion binding]; other site
298654015430	substrate binding site [chemical binding]; other site
298654015431	structural Zn binding site [ion binding]; other site
298654015432	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015434	NAD(P) binding site [chemical binding]; other site
298654015435	active site
298654015436	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654015437	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
298654015438	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015439	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015440	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015441	Cytochrome P450; Region: p450; cl12078
298654015442	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
298654015443	active site
298654015444	metal binding site [ion binding]; metal-binding site
298654015445	Cupin domain; Region: Cupin_2; cl17218
298654015446	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015447	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015448	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015449	Cytochrome P450; Region: p450; cl12078
298654015450	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654015451	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015452	classical (c) SDRs; Region: SDR_c; cd05233
298654015453	NAD(P) binding site [chemical binding]; other site
298654015454	active site
298654015455	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654015456	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654015457	[2Fe-2S] cluster binding site [ion binding]; other site
298654015458	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654015459	hydrophobic ligand binding site; other site
298654015460	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015461	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654015462	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015463	classical (c) SDRs; Region: SDR_c; cd05233
298654015464	NAD(P) binding site [chemical binding]; other site
298654015465	active site
298654015466	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298654015467	E3 interaction surface; other site
298654015468	lipoyl attachment site [posttranslational modification]; other site
298654015469	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
298654015470	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
298654015471	alpha subunit interface [polypeptide binding]; other site
298654015472	TPP binding site [chemical binding]; other site
298654015473	heterodimer interface [polypeptide binding]; other site
298654015474	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654015475	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
298654015476	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
298654015477	tetramer interface [polypeptide binding]; other site
298654015478	TPP-binding site [chemical binding]; other site
298654015479	heterodimer interface [polypeptide binding]; other site
298654015480	phosphorylation loop region [posttranslational modification]
298654015481	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015482	classical (c) SDRs; Region: SDR_c; cd05233
298654015483	NAD(P) binding site [chemical binding]; other site
298654015484	active site
298654015485	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
298654015486	putative dimer interface [polypeptide binding]; other site
298654015487	putative [2Fe-2S] cluster binding site [ion binding]; other site
298654015488	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654015489	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015490	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
298654015491	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654015492	NAD binding site [chemical binding]; other site
298654015493	catalytic residues [active]
298654015494	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654015495	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654015496	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654015497	[2Fe-2S] cluster binding site [ion binding]; other site
298654015498	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
298654015499	putative alpha subunit interface [polypeptide binding]; other site
298654015500	putative active site [active]
298654015501	putative substrate binding site [chemical binding]; other site
298654015502	Fe binding site [ion binding]; other site
298654015503	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015504	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654015505	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015506	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015507	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654015508	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015509	active site
298654015510	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
298654015511	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015512	active site
298654015513	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015514	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654015515	active site
298654015516	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654015517	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654015518	DNA-binding site [nucleotide binding]; DNA binding site
298654015519	Domain of unknown function (DUF955); Region: DUF955; cl01076
298654015520	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654015521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015522	NAD(P) binding site [chemical binding]; other site
298654015523	active site
298654015524	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298654015525	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015526	active site
298654015527	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654015528	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015529	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015530	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654015531	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654015532	TM-ABC transporter signature motif; other site
298654015533	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654015534	TM-ABC transporter signature motif; other site
298654015535	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654015536	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654015537	Walker A/P-loop; other site
298654015538	ATP binding site [chemical binding]; other site
298654015539	Q-loop/lid; other site
298654015540	ABC transporter signature motif; other site
298654015541	Walker B; other site
298654015542	D-loop; other site
298654015543	H-loop/switch region; other site
298654015544	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654015545	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654015546	NAD(P) binding site [chemical binding]; other site
298654015547	catalytic residues [active]
298654015548	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015549	Cytochrome P450; Region: p450; cl12078
298654015550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654015551	non-specific DNA binding site [nucleotide binding]; other site
298654015552	salt bridge; other site
298654015553	sequence-specific DNA binding site [nucleotide binding]; other site
298654015554	Cupin domain; Region: Cupin_2; cl17218
298654015555	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
298654015556	Methyltransferase domain; Region: Methyltransf_18; pfam12847
298654015557	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654015558	ligand binding site [chemical binding]; other site
298654015559	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654015560	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015561	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298654015562	CoenzymeA binding site [chemical binding]; other site
298654015563	subunit interaction site [polypeptide binding]; other site
298654015564	PHB binding site; other site
298654015565	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298654015566	active site 2 [active]
298654015567	active site 1 [active]
298654015568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015569	NAD(P) binding site [chemical binding]; other site
298654015570	active site
298654015571	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015572	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015573	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018
298654015574	non-heme iron binding site [ion binding]; other site
298654015575	dimer interface [polypeptide binding]; other site
298654015576	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
298654015577	catalytic triad [active]
298654015578	conserved cis-peptide bond; other site
298654015579	short chain dehydrogenase; Provisional; Region: PRK07791
298654015580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015581	NAD(P) binding site [chemical binding]; other site
298654015582	active site
298654015583	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015584	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015585	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654015586	nucleotide binding site [chemical binding]; other site
298654015587	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654015588	SBD interface [polypeptide binding]; other site
298654015589	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015591	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298654015592	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
298654015593	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
298654015594	putative catalytic cysteine [active]
298654015595	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654015596	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654015597	active site
298654015598	catalytic tetrad [active]
298654015599	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654015600	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015601	NAD(P) binding site [chemical binding]; other site
298654015602	active site
298654015603	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
298654015604	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
298654015605	active site
298654015606	iron coordination sites [ion binding]; other site
298654015607	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654015608	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654015609	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654015610	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654015611	[2Fe-2S] cluster binding site [ion binding]; other site
298654015612	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654015613	alpha subunit interface [polypeptide binding]; other site
298654015614	active site
298654015615	substrate binding site [chemical binding]; other site
298654015616	Fe binding site [ion binding]; other site
298654015617	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
298654015618	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654015619	catalytic loop [active]
298654015620	iron binding site [ion binding]; other site
298654015621	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
298654015622	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
298654015623	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
298654015624	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654015625	Cytochrome P450; Region: p450; cl12078
298654015626	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
298654015627	putative hydrophobic ligand binding site [chemical binding]; other site
298654015628	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
298654015629	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
298654015630	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298654015631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015633	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654015634	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654015635	DNA-binding site [nucleotide binding]; DNA binding site
298654015636	FCD domain; Region: FCD; pfam07729
298654015637	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298654015638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654015639	DNA-binding site [nucleotide binding]; DNA binding site
298654015640	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654015641	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015642	substrate binding site [chemical binding]; other site
298654015643	oxyanion hole (OAH) forming residues; other site
298654015644	trimer interface [polypeptide binding]; other site
298654015645	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654015646	classical (c) SDRs; Region: SDR_c; cd05233
298654015647	NAD(P) binding site [chemical binding]; other site
298654015648	active site
298654015649	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015651	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
298654015652	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298654015653	Active Sites [active]
298654015654	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
298654015655	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
298654015656	CysD dimerization site [polypeptide binding]; other site
298654015657	G1 box; other site
298654015658	putative GEF interaction site [polypeptide binding]; other site
298654015659	GTP/Mg2+ binding site [chemical binding]; other site
298654015660	Switch I region; other site
298654015661	G2 box; other site
298654015662	G3 box; other site
298654015663	Switch II region; other site
298654015664	G4 box; other site
298654015665	G5 box; other site
298654015666	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
298654015667	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
298654015668	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
298654015669	ligand-binding site [chemical binding]; other site
298654015670	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
298654015671	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
298654015672	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654015673	AlkA N-terminal domain; Region: AlkA_N; pfam06029
298654015674	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
298654015675	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298654015676	minor groove reading motif; other site
298654015677	helix-hairpin-helix signature motif; other site
298654015678	active site
298654015679	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
298654015680	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
298654015681	DNA binding site [nucleotide binding]
298654015682	active site
298654015683	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654015684	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015685	acyl-activating enzyme (AAE) consensus motif; other site
298654015686	AMP binding site [chemical binding]; other site
298654015687	active site
298654015688	CoA binding site [chemical binding]; other site
298654015689	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015690	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298654015691	NIPSNAP; Region: NIPSNAP; pfam07978
298654015692	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
298654015693	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654015694	active site
298654015695	enoyl-CoA hydratase; Provisional; Region: PRK05870
298654015696	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015697	substrate binding site [chemical binding]; other site
298654015698	oxyanion hole (OAH) forming residues; other site
298654015699	trimer interface [polypeptide binding]; other site
298654015700	classical (c) SDRs; Region: SDR_c; cd05233
298654015701	NAD(P) binding site [chemical binding]; other site
298654015702	active site
298654015703	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654015704	classical (c) SDRs; Region: SDR_c; cd05233
298654015705	NAD(P) binding site [chemical binding]; other site
298654015706	active site
298654015707	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015708	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654015709	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654015710	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654015711	Walker A/P-loop; other site
298654015712	ATP binding site [chemical binding]; other site
298654015713	Q-loop/lid; other site
298654015714	ABC transporter signature motif; other site
298654015715	Walker B; other site
298654015716	D-loop; other site
298654015717	H-loop/switch region; other site
298654015718	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654015719	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654015720	Walker A/P-loop; other site
298654015721	ATP binding site [chemical binding]; other site
298654015722	Q-loop/lid; other site
298654015723	ABC transporter signature motif; other site
298654015724	Walker B; other site
298654015725	D-loop; other site
298654015726	H-loop/switch region; other site
298654015727	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654015728	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654015729	TM-ABC transporter signature motif; other site
298654015730	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
298654015731	TM-ABC transporter signature motif; other site
298654015732	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654015733	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015734	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015735	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015736	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015737	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
298654015738	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654015739	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654015740	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654015741	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
298654015742	DUF35 OB-fold domain; Region: DUF35; pfam01796
298654015743	lipid-transfer protein; Provisional; Region: PRK07855
298654015744	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
298654015745	active site
298654015746	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654015747	MarR family; Region: MarR; pfam01047
298654015748	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654015749	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015750	substrate binding site [chemical binding]; other site
298654015751	oxyanion hole (OAH) forming residues; other site
298654015752	trimer interface [polypeptide binding]; other site
298654015753	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
298654015754	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
298654015755	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654015756	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298654015757	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654015758	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015759	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
298654015760	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
298654015761	acyl-activating enzyme (AAE) consensus motif; other site
298654015762	acyl-activating enzyme (AAE) consensus motif; other site
298654015763	putative AMP binding site [chemical binding]; other site
298654015764	putative active site [active]
298654015765	putative CoA binding site [chemical binding]; other site
298654015766	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654015767	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
298654015768	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
298654015769	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654015770	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654015771	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015772	substrate binding site [chemical binding]; other site
298654015773	oxyanion hole (OAH) forming residues; other site
298654015774	trimer interface [polypeptide binding]; other site
298654015775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654015776	PAS fold; Region: PAS_3; pfam08447
298654015777	putative active site [active]
298654015778	heme pocket [chemical binding]; other site
298654015779	PAS fold; Region: PAS_4; pfam08448
298654015780	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654015781	putative active site [active]
298654015782	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654015783	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654015784	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654015785	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654015786	phosphopeptide binding site; other site
298654015787	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
298654015788	AAA domain; Region: AAA_33; pfam13671
298654015789	ATP-binding site [chemical binding]; other site
298654015790	Gluconate-6-phosphate binding site [chemical binding]; other site
298654015791	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
298654015792	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
298654015793	dimerization interface [polypeptide binding]; other site
298654015794	ATP binding site [chemical binding]; other site
298654015795	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
298654015796	dimerization interface [polypeptide binding]; other site
298654015797	ATP binding site [chemical binding]; other site
298654015798	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
298654015799	putative active site [active]
298654015800	catalytic triad [active]
298654015801	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654015802	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015803	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015804	acyl-activating enzyme (AAE) consensus motif; other site
298654015805	acyl-activating enzyme (AAE) consensus motif; other site
298654015806	AMP binding site [chemical binding]; other site
298654015807	active site
298654015808	CoA binding site [chemical binding]; other site
298654015809	oxidoreductase; Provisional; Region: PRK06196
298654015810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654015811	NAD(P) binding site [chemical binding]; other site
298654015812	active site
298654015813	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
298654015814	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654015815	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654015816	active site
298654015817	ATP binding site [chemical binding]; other site
298654015818	substrate binding site [chemical binding]; other site
298654015819	activation loop (A-loop); other site
298654015820	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
298654015821	intersubunit interface [polypeptide binding]; other site
298654015822	active site
298654015823	zinc binding site [ion binding]; other site
298654015824	Na+ binding site [ion binding]; other site
298654015825	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
298654015826	ATP binding site [chemical binding]; other site
298654015827	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
298654015828	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
298654015829	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
298654015830	dimer interface [polypeptide binding]; other site
298654015831	active site
298654015832	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298654015833	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298654015834	substrate binding site [chemical binding]; other site
298654015835	ATP binding site [chemical binding]; other site
298654015836	alpha-galactosidase; Provisional; Region: PRK15076
298654015837	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
298654015838	NAD(P) binding site [chemical binding]; other site
298654015839	LDH/MDH dimer interface [polypeptide binding]; other site
298654015840	substrate binding site [chemical binding]; other site
298654015841	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
298654015842	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
298654015843	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298654015844	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
298654015845	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654015846	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
298654015847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654015848	dimer interface [polypeptide binding]; other site
298654015849	conserved gate region; other site
298654015850	putative PBP binding loops; other site
298654015851	ABC-ATPase subunit interface; other site
298654015852	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654015853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654015854	dimer interface [polypeptide binding]; other site
298654015855	conserved gate region; other site
298654015856	putative PBP binding loops; other site
298654015857	ABC-ATPase subunit interface; other site
298654015858	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015859	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654015860	putative ligand binding site [chemical binding]; other site
298654015861	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
298654015862	acyl-CoA synthetase; Provisional; Region: PRK13388
298654015863	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654015864	acyl-activating enzyme (AAE) consensus motif; other site
298654015865	AMP binding site [chemical binding]; other site
298654015866	active site
298654015867	CoA binding site [chemical binding]; other site
298654015868	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015869	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654015870	putative ligand binding site [chemical binding]; other site
298654015871	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015872	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654015873	sequence-specific DNA binding site [nucleotide binding]; other site
298654015874	salt bridge; other site
298654015875	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
298654015876	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654015877	catalytic residue [active]
298654015878	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298654015879	Fic/DOC family; Region: Fic; cl00960
298654015880	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
298654015881	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_16; cd04674
298654015882	nudix motif; other site
298654015883	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
298654015884	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654015885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654015886	active site
298654015887	phosphorylation site [posttranslational modification]
298654015888	intermolecular recognition site; other site
298654015889	dimerization interface [polypeptide binding]; other site
298654015890	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654015891	DNA binding residues [nucleotide binding]
298654015892	dimerization interface [polypeptide binding]; other site
298654015893	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654015894	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
298654015895	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
298654015896	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654015897	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654015898	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654015899	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654015900	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654015901	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
298654015902	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
298654015903	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
298654015904	ANTAR domain; Region: ANTAR; pfam03861
298654015905	PAS fold; Region: PAS_3; pfam08447
298654015906	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
298654015907	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654015908	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298654015909	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654015910	dimerization interface [polypeptide binding]; other site
298654015911	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654015912	dimerization interface [polypeptide binding]; other site
298654015913	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298654015914	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654015915	dimerization interface [polypeptide binding]; other site
298654015916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654015917	dimerization interface [polypeptide binding]; other site
298654015918	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654015919	dimerization interface [polypeptide binding]; other site
298654015920	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298654015921	dimerization interface [polypeptide binding]; other site
298654015922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654015923	dimer interface [polypeptide binding]; other site
298654015924	phosphorylation site [posttranslational modification]
298654015925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654015926	ATP binding site [chemical binding]; other site
298654015927	Mg2+ binding site [ion binding]; other site
298654015928	G-X-G motif; other site
298654015929	Response regulator receiver domain; Region: Response_reg; pfam00072
298654015930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654015931	active site
298654015932	phosphorylation site [posttranslational modification]
298654015933	intermolecular recognition site; other site
298654015934	dimerization interface [polypeptide binding]; other site
298654015935	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654015936	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654015937	active site
298654015938	metal binding site [ion binding]; metal-binding site
298654015939	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
298654015940	DNA binding site [nucleotide binding]
298654015941	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654015942	Predicted ATPase [General function prediction only]; Region: COG3903
298654015943	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
298654015944	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
298654015945	putative NAD(P) binding site [chemical binding]; other site
298654015946	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
298654015947	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
298654015948	active site
298654015949	Zn binding site [ion binding]; other site
298654015950	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
298654015951	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
298654015952	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015953	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654015954	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654015955	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654015956	putative ligand binding site [chemical binding]; other site
298654015957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654015958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654015959	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654015960	classical (c) SDRs; Region: SDR_c; cd05233
298654015961	NAD(P) binding site [chemical binding]; other site
298654015962	active site
298654015963	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
298654015964	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
298654015965	ligand binding site [chemical binding]; other site
298654015966	NAD binding site [chemical binding]; other site
298654015967	tetramer interface [polypeptide binding]; other site
298654015968	catalytic site [active]
298654015969	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
298654015970	L-serine binding site [chemical binding]; other site
298654015971	ACT domain interface; other site
298654015972	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654015973	FAD binding domain; Region: FAD_binding_4; pfam01565
298654015974	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298654015975	homotrimer interaction site [polypeptide binding]; other site
298654015976	putative active site [active]
298654015977	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654015978	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298654015979	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654015980	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654015981	substrate binding site [chemical binding]; other site
298654015982	oxyanion hole (OAH) forming residues; other site
298654015983	trimer interface [polypeptide binding]; other site
298654015984	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654015985	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654015986	classical (c) SDRs; Region: SDR_c; cd05233
298654015987	NAD(P) binding site [chemical binding]; other site
298654015988	active site
298654015989	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654015990	putative active site [active]
298654015991	putative substrate binding site [chemical binding]; other site
298654015992	ATP binding site [chemical binding]; other site
298654015993	Phosphotransferase enzyme family; Region: APH; pfam01636
298654015994	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
298654015995	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654015996	dimer interface [polypeptide binding]; other site
298654015997	active site
298654015998	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654015999	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654016000	active site
298654016001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016002	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016003	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
298654016004	homodimer interface [polypeptide binding]; other site
298654016005	short chain dehydrogenase; Provisional; Region: PRK07791
298654016006	NAD binding site [chemical binding]; other site
298654016007	active site
298654016008	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298654016009	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298654016010	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
298654016011	inhibitor binding site; inhibition site
298654016012	active site
298654016013	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
298654016014	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
298654016015	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
298654016016	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
298654016017	ligand binding site [chemical binding]; other site
298654016018	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
298654016019	galactokinase; Provisional; Region: PRK05101
298654016020	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
298654016021	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
298654016022	dimer interface [polypeptide binding]; other site
298654016023	active site
298654016024	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
298654016025	beta-galactosidase; Region: BGL; TIGR03356
298654016026	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654016027	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654016028	TM-ABC transporter signature motif; other site
298654016029	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654016030	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654016031	Walker A/P-loop; other site
298654016032	ATP binding site [chemical binding]; other site
298654016033	Q-loop/lid; other site
298654016034	ABC transporter signature motif; other site
298654016035	Walker B; other site
298654016036	D-loop; other site
298654016037	H-loop/switch region; other site
298654016038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654016039	putative substrate translocation pore; other site
298654016040	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654016041	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654016042	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654016043	Walker A/P-loop; other site
298654016044	ATP binding site [chemical binding]; other site
298654016045	Q-loop/lid; other site
298654016046	ABC transporter signature motif; other site
298654016047	Walker B; other site
298654016048	D-loop; other site
298654016049	H-loop/switch region; other site
298654016050	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298654016051	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298654016052	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298654016053	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
298654016054	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
298654016055	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
298654016056	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
298654016057	glucuronate isomerase; Reviewed; Region: PRK02925
298654016058	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
298654016059	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654016060	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654016061	DNA binding site [nucleotide binding]
298654016062	domain linker motif; other site
298654016063	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
298654016064	dimerization interface [polypeptide binding]; other site
298654016065	ligand binding site [chemical binding]; other site
298654016066	beta-D-glucuronidase; Provisional; Region: PRK10150
298654016067	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298654016068	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298654016069	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298654016070	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654016071	Nuclease-related domain; Region: NERD; pfam08378
298654016072	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654016073	active site
298654016074	ATP binding site [chemical binding]; other site
298654016075	substrate binding site [chemical binding]; other site
298654016076	activation loop (A-loop); other site
298654016077	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654016078	Protein kinase domain; Region: Pkinase; pfam00069
298654016079	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654016080	active site
298654016081	ATP binding site [chemical binding]; other site
298654016082	substrate binding site [chemical binding]; other site
298654016083	activation loop (A-loop); other site
298654016084	Methyltransferase domain; Region: Methyltransf_26; pfam13659
298654016085	primosomal protein DnaI; Reviewed; Region: PRK08939
298654016086	PglZ domain; Region: PglZ; pfam08665
298654016087	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
298654016088	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
298654016089	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654016090	putative Mg++ binding site [ion binding]; other site
298654016091	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654016092	nucleotide binding region [chemical binding]; other site
298654016093	ATP-binding site [chemical binding]; other site
298654016094	SeqA protein; Region: SeqA; cl11470
298654016095	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654016096	active site
298654016097	hypothetical protein; Provisional; Region: PRK06762
298654016098	AAA domain; Region: AAA_33; pfam13671
298654016099	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
298654016100	RNA/DNA hybrid binding site [nucleotide binding]; other site
298654016101	active site
298654016102	TIR domain; Region: TIR_2; pfam13676
298654016103	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
298654016104	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654016105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654016106	active site
298654016107	phosphorylation site [posttranslational modification]
298654016108	intermolecular recognition site; other site
298654016109	dimerization interface [polypeptide binding]; other site
298654016110	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654016111	DNA binding residues [nucleotide binding]
298654016112	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654016113	Histidine kinase; Region: HisKA_3; pfam07730
298654016114	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654016115	Secretory lipase; Region: LIP; pfam03583
298654016116	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
298654016117	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
298654016118	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654016119	FAD binding domain; Region: FAD_binding_3; pfam01494
298654016120	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654016121	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
298654016122	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
298654016123	nucleophilic elbow; other site
298654016124	catalytic triad; other site
298654016125	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654016126	classical (c) SDRs; Region: SDR_c; cd05233
298654016127	NAD(P) binding site [chemical binding]; other site
298654016128	active site
298654016129	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
298654016130	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
298654016131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654016132	putative active site [active]
298654016133	putative metal binding site [ion binding]; other site
298654016134	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
298654016135	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
298654016136	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654016137	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654016138	TM-ABC transporter signature motif; other site
298654016139	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298654016140	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298654016141	Walker A/P-loop; other site
298654016142	ATP binding site [chemical binding]; other site
298654016143	Q-loop/lid; other site
298654016144	ABC transporter signature motif; other site
298654016145	Walker B; other site
298654016146	D-loop; other site
298654016147	H-loop/switch region; other site
298654016148	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298654016149	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
298654016150	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
298654016151	ligand binding site [chemical binding]; other site
298654016152	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298654016153	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016154	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016155	active site
298654016156	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654016157	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654016158	NAD(P) binding site [chemical binding]; other site
298654016159	catalytic residues [active]
298654016160	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
298654016161	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654016162	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654016163	DNA-binding site [nucleotide binding]; DNA binding site
298654016164	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298654016165	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
298654016166	TPP-binding site [chemical binding]; other site
298654016167	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
298654016168	PYR/PP interface [polypeptide binding]; other site
298654016169	dimer interface [polypeptide binding]; other site
298654016170	TPP binding site [chemical binding]; other site
298654016171	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
298654016172	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298654016173	AsnC family; Region: AsnC_trans_reg; pfam01037
298654016174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
298654016175	Protein of unknown function, DUF462; Region: DUF462; cl01190
298654016176	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
298654016177	RibD C-terminal domain; Region: RibD_C; cl17279
298654016178	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
298654016179	catalytic site [active]
298654016180	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
298654016181	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654016182	ATP binding site [chemical binding]; other site
298654016183	putative Mg++ binding site [ion binding]; other site
298654016184	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
298654016185	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
298654016186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654016187	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
298654016188	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654016189	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
298654016190	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654016191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654016192	S-adenosylmethionine binding site [chemical binding]; other site
298654016193	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
298654016194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016195	NAD(P) binding site [chemical binding]; other site
298654016196	active site
298654016197	Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222
298654016198	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
298654016199	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
298654016200	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654016201	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654016202	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
298654016203	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
298654016204	putative active site [active]
298654016205	catalytic site [active]
298654016206	putative metal binding site [ion binding]; other site
298654016207	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016208	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654016209	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654016210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654016211	putative substrate translocation pore; other site
298654016212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016213	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
298654016214	NAD(P) binding site [chemical binding]; other site
298654016215	active site
298654016216	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654016217	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654016218	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654016219	substrate binding site [chemical binding]; other site
298654016220	oxyanion hole (OAH) forming residues; other site
298654016221	trimer interface [polypeptide binding]; other site
298654016222	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298654016223	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
298654016224	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298654016225	dimer interface [polypeptide binding]; other site
298654016226	active site
298654016227	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654016228	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298654016229	TAP-like protein; Region: Abhydrolase_4; pfam08386
298654016230	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298654016231	G1 box; other site
298654016232	GTP/Mg2+ binding site [chemical binding]; other site
298654016233	G2 box; other site
298654016234	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
298654016235	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654016236	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654016237	DNA binding residues [nucleotide binding]
298654016238	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298654016239	G3 box; other site
298654016240	Switch II region; other site
298654016241	GTP/Mg2+ binding site [chemical binding]; other site
298654016242	G4 box; other site
298654016243	G5 box; other site
298654016244	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
298654016245	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
298654016246	Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077
298654016247	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654016248	nucleotide binding site [chemical binding]; other site
298654016249	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654016250	SBD interface [polypeptide binding]; other site
298654016251	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654016252	nucleotide binding site [chemical binding]; other site
298654016253	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654016254	SBD interface [polypeptide binding]; other site
298654016255	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
298654016256	PQQ-like domain; Region: PQQ_2; pfam13360
298654016257	Trp docking motif [polypeptide binding]; other site
298654016258	active site
298654016259	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298654016260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654016261	Walker A/P-loop; other site
298654016262	ATP binding site [chemical binding]; other site
298654016263	ABC transporter; Region: ABC_tran; pfam00005
298654016264	Q-loop/lid; other site
298654016265	ABC transporter signature motif; other site
298654016266	Walker B; other site
298654016267	D-loop; other site
298654016268	H-loop/switch region; other site
298654016269	Part of AAA domain; Region: AAA_19; pfam13245
298654016270	endonuclease III; Region: ENDO3c; smart00478
298654016271	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654016272	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654016273	active site
298654016274	ATP binding site [chemical binding]; other site
298654016275	substrate binding site [chemical binding]; other site
298654016276	activation loop (A-loop); other site
298654016277	hypothetical protein; Provisional; Region: PRK07877
298654016278	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
298654016279	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654016280	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654016281	active site
298654016282	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298654016283	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298654016284	substrate binding site [chemical binding]; other site
298654016285	oxyanion hole (OAH) forming residues; other site
298654016286	trimer interface [polypeptide binding]; other site
298654016287	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654016288	Cytochrome P450; Region: p450; cl12078
298654016289	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
298654016290	classical (c) SDRs; Region: SDR_c; cd05233
298654016291	NAD(P) binding site [chemical binding]; other site
298654016292	active site
298654016293	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016294	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016295	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654016296	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654016297	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
298654016298	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654016299	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
298654016300	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
298654016301	putative active site [active]
298654016302	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
298654016303	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
298654016304	YCII-related domain; Region: YCII; cl00999
298654016305	short chain dehydrogenase; Provisional; Region: PRK06179
298654016306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016307	NAD(P) binding site [chemical binding]; other site
298654016308	active site
298654016309	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654016310	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654016311	active site
298654016312	ATP binding site [chemical binding]; other site
298654016313	substrate binding site [chemical binding]; other site
298654016314	activation loop (A-loop); other site
298654016315	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
298654016316	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
298654016317	Cupin domain; Region: Cupin_2; cl17218
298654016318	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654016319	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654016320	Cytochrome P450; Region: p450; cl12078
298654016321	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654016322	phosphopeptide binding site; other site
298654016323	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654016324	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
298654016325	phosphopeptide binding site; other site
298654016326	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
298654016327	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654016328	Walker A/P-loop; other site
298654016329	ATP binding site [chemical binding]; other site
298654016330	Q-loop/lid; other site
298654016331	ABC transporter signature motif; other site
298654016332	Walker B; other site
298654016333	D-loop; other site
298654016334	H-loop/switch region; other site
298654016335	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654016336	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298654016337	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
298654016338	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016339	NAD(P) binding site [chemical binding]; other site
298654016340	active site
298654016341	FAD binding domain; Region: FAD_binding_4; pfam01565
298654016342	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654016343	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
298654016344	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
298654016345	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
298654016346	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016347	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016348	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
298654016349	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
298654016350	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
298654016351	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
298654016352	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
298654016353	ligand binding site [chemical binding]; other site
298654016354	homodimer interface [polypeptide binding]; other site
298654016355	NAD(P) binding site [chemical binding]; other site
298654016356	trimer interface B [polypeptide binding]; other site
298654016357	trimer interface A [polypeptide binding]; other site
298654016358	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016359	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654016361	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
298654016362	active site
298654016363	catalytic triad [active]
298654016364	oxyanion hole [active]
298654016365	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
298654016366	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654016367	NAD(P) binding site [chemical binding]; other site
298654016368	catalytic residues [active]
298654016369	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
298654016370	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
298654016371	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298654016372	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654016373	ATP binding site [chemical binding]; other site
298654016374	putative Mg++ binding site [ion binding]; other site
298654016375	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654016376	nucleotide binding region [chemical binding]; other site
298654016377	ATP-binding site [chemical binding]; other site
298654016378	Helicase associated domain (HA2); Region: HA2; pfam04408
298654016379	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
298654016380	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
298654016381	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298654016382	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654016383	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
298654016384	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
298654016385	Cupin domain; Region: Cupin_2; cl17218
298654016386	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
298654016387	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
298654016388	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
298654016389	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
298654016390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654016391	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
298654016392	Walker A/P-loop; other site
298654016393	ATP binding site [chemical binding]; other site
298654016394	Q-loop/lid; other site
298654016395	ABC transporter signature motif; other site
298654016396	Walker B; other site
298654016397	D-loop; other site
298654016398	H-loop/switch region; other site
298654016399	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654016400	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654016401	TM-ABC transporter signature motif; other site
298654016402	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654016403	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654016404	TM-ABC transporter signature motif; other site
298654016405	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654016406	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654016407	Walker A/P-loop; other site
298654016408	ATP binding site [chemical binding]; other site
298654016409	Q-loop/lid; other site
298654016410	ABC transporter signature motif; other site
298654016411	Walker B; other site
298654016412	D-loop; other site
298654016413	H-loop/switch region; other site
298654016414	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654016415	putative metal binding site [ion binding]; other site
298654016416	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654016417	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
298654016418	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
298654016419	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654016420	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654016421	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298654016422	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298654016423	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
298654016424	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016425	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016426	active site
298654016427	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
298654016428	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298654016429	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016430	active site
298654016431	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654016432	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654016433	active site
298654016434	catalytic tetrad [active]
298654016435	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654016436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654016437	DNA binding site [nucleotide binding]
298654016438	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654016439	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
298654016440	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
298654016441	L-aspartate oxidase; Provisional; Region: PRK06175
298654016442	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
298654016443	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
298654016444	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654016445	catalytic loop [active]
298654016446	iron binding site [ion binding]; other site
298654016447	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
298654016448	Chain length determinant protein; Region: Wzz; cl15801
298654016449	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
298654016450	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298654016451	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
298654016452	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
298654016453	NAD(P) binding site [chemical binding]; other site
298654016454	homodimer interface [polypeptide binding]; other site
298654016455	substrate binding site [chemical binding]; other site
298654016456	active site
298654016457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016458	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
298654016459	NAD(P) binding site [chemical binding]; other site
298654016460	active site
298654016461	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
298654016462	putative trimer interface [polypeptide binding]; other site
298654016463	putative CoA binding site [chemical binding]; other site
298654016464	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
298654016465	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
298654016466	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
298654016467	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
298654016468	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
298654016469	active site
298654016470	dimerization interface [polypeptide binding]; other site
298654016471	ribonuclease PH; Reviewed; Region: rph; PRK00173
298654016472	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
298654016473	oligomer interface [polypeptide binding]; other site
298654016474	RNA binding site [nucleotide binding]; other site
298654016475	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
298654016476	glutamate racemase; Provisional; Region: PRK00865
298654016477	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654016478	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654016479	active site
298654016480	DNA binding site [nucleotide binding]
298654016481	Int/Topo IB signature motif; other site
298654016482	NB-ARC domain; Region: NB-ARC; pfam00931
298654016483	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
298654016484	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654016485	catalytic residue [active]
298654016486	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
298654016487	nudix motif; other site
298654016488	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
298654016489	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654016490	DNA-binding site [nucleotide binding]; DNA binding site
298654016491	UTRA domain; Region: UTRA; pfam07702
298654016492	DNA binding domain, excisionase family; Region: excise; TIGR01764
298654016493	Transcription factor WhiB; Region: Whib; pfam02467
298654016494	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
298654016495	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
298654016496	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654016497	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654016498	catalytic residue [active]
298654016499	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654016500	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
298654016501	Transcription factor WhiB; Region: Whib; pfam02467
298654016502	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
298654016503	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
298654016504	cofactor binding site; other site
298654016505	DNA binding site [nucleotide binding]
298654016506	substrate interaction site [chemical binding]; other site
298654016507	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
298654016508	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
298654016509	polymerase nucleotide-binding site; other site
298654016510	DNA-binding residues [nucleotide binding]; DNA binding site
298654016511	nucleotide binding site [chemical binding]; other site
298654016512	primase nucleotide-binding site [nucleotide binding]; other site
298654016513	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
298654016514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654016515	binding surface
298654016516	TPR motif; other site
298654016517	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654016518	binding surface
298654016519	TPR motif; other site
298654016520	Winged helix-turn helix; Region: HTH_29; pfam13551
298654016521	Helix-turn-helix domain; Region: HTH_28; pfam13518
298654016522	Homeodomain-like domain; Region: HTH_32; pfam13565
298654016523	Integrase core domain; Region: rve; pfam00665
298654016524	Integrase core domain; Region: rve_3; pfam13683
298654016525	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
298654016526	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
298654016527	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
298654016528	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
298654016529	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
298654016530	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
298654016531	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
298654016532	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
298654016533	TIR domain; Region: TIR_2; pfam13676
298654016534	AAA ATPase domain; Region: AAA_16; pfam13191
298654016535	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654016536	WD domain, G-beta repeat; Region: WD40; pfam00400
298654016537	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654016538	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654016539	structural tetrad; other site
298654016540	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654016541	structural tetrad; other site
298654016542	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298654016543	dimer interface [polypeptide binding]; other site
298654016544	ADP-ribose binding site [chemical binding]; other site
298654016545	active site
298654016546	nudix motif; other site
298654016547	metal binding site [ion binding]; metal-binding site
298654016548	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298654016549	dimer interface [polypeptide binding]; other site
298654016550	ADP-ribose binding site [chemical binding]; other site
298654016551	active site
298654016552	nudix motif; other site
298654016553	metal binding site [ion binding]; metal-binding site
298654016554	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
298654016555	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
298654016556	dimer interface [polypeptide binding]; other site
298654016557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654016558	catalytic residue [active]
298654016559	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
298654016560	MoaE interaction surface [polypeptide binding]; other site
298654016561	MoeB interaction surface [polypeptide binding]; other site
298654016562	thiocarboxylated glycine; other site
298654016563	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
298654016564	MPN+ (JAMM) motif; other site
298654016565	Zinc-binding site [ion binding]; other site
298654016566	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
298654016567	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
298654016568	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
298654016569	nudix motif; other site
298654016570	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
298654016571	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
298654016572	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
298654016573	active site
298654016574	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654016575	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654016576	non-specific DNA binding site [nucleotide binding]; other site
298654016577	salt bridge; other site
298654016578	sequence-specific DNA binding site [nucleotide binding]; other site
298654016579	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
298654016580	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016581	NAD(P) binding site [chemical binding]; other site
298654016582	active site
298654016583	SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263
298654016584	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654016585	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654016586	TM-ABC transporter signature motif; other site
298654016587	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654016588	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654016589	TM-ABC transporter signature motif; other site
298654016590	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654016591	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654016592	Walker A/P-loop; other site
298654016593	ATP binding site [chemical binding]; other site
298654016594	Q-loop/lid; other site
298654016595	ABC transporter signature motif; other site
298654016596	Walker B; other site
298654016597	D-loop; other site
298654016598	H-loop/switch region; other site
298654016599	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654016600	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654016601	Walker A/P-loop; other site
298654016602	ATP binding site [chemical binding]; other site
298654016603	Q-loop/lid; other site
298654016604	ABC transporter signature motif; other site
298654016605	Walker B; other site
298654016606	D-loop; other site
298654016607	H-loop/switch region; other site
298654016608	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654016609	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654016610	putative ligand binding site [chemical binding]; other site
298654016611	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654016612	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298654016613	Walker A/P-loop; other site
298654016614	ATP binding site [chemical binding]; other site
298654016615	Q-loop/lid; other site
298654016616	ABC transporter signature motif; other site
298654016617	Walker B; other site
298654016618	D-loop; other site
298654016619	H-loop/switch region; other site
298654016620	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
298654016621	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
298654016622	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
298654016623	agmatinase; Region: agmatinase; TIGR01230
298654016624	Agmatinase-like family; Region: Agmatinase-like; cd09990
298654016625	active site
298654016626	oligomer interface [polypeptide binding]; other site
298654016627	Mn binding site [ion binding]; other site
298654016628	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
298654016629	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
298654016630	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
298654016631	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
298654016632	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
298654016633	active site
298654016634	putative substrate binding pocket [chemical binding]; other site
298654016635	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298654016636	adenosine deaminase; Provisional; Region: PRK09358
298654016637	active site
298654016638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654016639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654016640	Coenzyme A binding pocket [chemical binding]; other site
298654016641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654016642	non-specific DNA binding site [nucleotide binding]; other site
298654016643	salt bridge; other site
298654016644	sequence-specific DNA binding site [nucleotide binding]; other site
298654016645	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016646	short chain dehydrogenase; Provisional; Region: PRK06197
298654016647	NAD(P) binding site [chemical binding]; other site
298654016648	active site
298654016649	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
298654016650	active site
298654016651	homotetramer interface [polypeptide binding]; other site
298654016652	AAA ATPase domain; Region: AAA_16; pfam13191
298654016653	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654016654	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
298654016655	DNA binding residues [nucleotide binding]
298654016656	dimerization interface [polypeptide binding]; other site
298654016657	putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797
298654016658	Allantoicase repeat; Region: Allantoicase; pfam03561
298654016659	Allantoicase repeat; Region: Allantoicase; pfam03561
298654016660	OHCU decarboxylase; Region: UraD_2; TIGR03180
298654016661	allantoinase; Region: allantoinase; TIGR03178
298654016662	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016663	active site
298654016664	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
298654016665	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
298654016666	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298654016667	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
298654016668	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
298654016669	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
298654016670	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
298654016671	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654016672	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654016673	[2Fe-2S] cluster binding site [ion binding]; other site
298654016674	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654016675	hydrophobic ligand binding site; other site
298654016676	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
298654016677	MarR family; Region: MarR_2; pfam12802
298654016678	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016679	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016680	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654016681	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
298654016682	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
298654016683	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654016684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654016685	dimer interface [polypeptide binding]; other site
298654016686	conserved gate region; other site
298654016687	putative PBP binding loops; other site
298654016688	ABC-ATPase subunit interface; other site
298654016689	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298654016690	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298654016691	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654016692	Walker A/P-loop; other site
298654016693	ATP binding site [chemical binding]; other site
298654016694	Q-loop/lid; other site
298654016695	ABC transporter signature motif; other site
298654016696	Walker B; other site
298654016697	D-loop; other site
298654016698	H-loop/switch region; other site
298654016699	NMT1/THI5 like; Region: NMT1; pfam09084
298654016700	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
298654016701	alpha-gamma subunit interface [polypeptide binding]; other site
298654016702	beta-gamma subunit interface [polypeptide binding]; other site
298654016703	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
298654016704	gamma-beta subunit interface [polypeptide binding]; other site
298654016705	alpha-beta subunit interface [polypeptide binding]; other site
298654016706	urease subunit alpha; Reviewed; Region: ureC; PRK13206
298654016707	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
298654016708	subunit interactions [polypeptide binding]; other site
298654016709	active site
298654016710	flap region; other site
298654016711	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654016712	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
298654016713	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
298654016714	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654016715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654016716	active site
298654016717	phosphorylation site [posttranslational modification]
298654016718	intermolecular recognition site; other site
298654016719	dimerization interface [polypeptide binding]; other site
298654016720	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654016721	DNA binding site [nucleotide binding]
298654016722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654016723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654016724	dimer interface [polypeptide binding]; other site
298654016725	phosphorylation site [posttranslational modification]
298654016726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654016727	ATP binding site [chemical binding]; other site
298654016728	Mg2+ binding site [ion binding]; other site
298654016729	G-X-G motif; other site
298654016730	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
298654016731	active site
298654016732	putative catalytic site [active]
298654016733	UreD urease accessory protein; Region: UreD; cl00530
298654016734	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298654016735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654016736	putative substrate translocation pore; other site
298654016737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654016738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016740	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
298654016741	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654016742	FeS/SAM binding site; other site
298654016743	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
298654016744	Predicted transcriptional regulators [Transcription]; Region: COG1733
298654016745	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
298654016746	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
298654016747	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
298654016748	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
298654016749	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
298654016750	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
298654016751	Active site cavity [active]
298654016752	catalytic acid [active]
298654016753	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
298654016754	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
298654016755	substrate binding pocket [chemical binding]; other site
298654016756	chain length determination region; other site
298654016757	substrate-Mg2+ binding site; other site
298654016758	catalytic residues [active]
298654016759	aspartate-rich region 1; other site
298654016760	active site lid residues [active]
298654016761	aspartate-rich region 2; other site
298654016762	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298654016763	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
298654016764	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
298654016765	active site lid residues [active]
298654016766	substrate binding pocket [chemical binding]; other site
298654016767	catalytic residues [active]
298654016768	substrate-Mg2+ binding site; other site
298654016769	aspartate-rich region 1; other site
298654016770	aspartate-rich region 2; other site
298654016771	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
298654016772	active site lid residues [active]
298654016773	substrate binding pocket [chemical binding]; other site
298654016774	catalytic residues [active]
298654016775	substrate-Mg2+ binding site; other site
298654016776	aspartate-rich region 1; other site
298654016777	aspartate-rich region 2; other site
298654016778	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
298654016779	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016780	NAD(P) binding site [chemical binding]; other site
298654016781	active site
298654016782	hypothetical protein; Provisional; Region: PRK06062
298654016783	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654016784	inhibitor-cofactor binding pocket; inhibition site
298654016785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654016786	catalytic residue [active]
298654016787	NMT1/THI5 like; Region: NMT1; pfam09084
298654016788	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
298654016789	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
298654016790	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
298654016791	Walker A/P-loop; other site
298654016792	ATP binding site [chemical binding]; other site
298654016793	ABC transporter; Region: ABC_tran; pfam00005
298654016794	Q-loop/lid; other site
298654016795	ABC transporter signature motif; other site
298654016796	Walker B; other site
298654016797	D-loop; other site
298654016798	H-loop/switch region; other site
298654016799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654016800	dimer interface [polypeptide binding]; other site
298654016801	conserved gate region; other site
298654016802	ABC-ATPase subunit interface; other site
298654016803	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654016804	F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842
298654016805	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
298654016806	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
298654016807	tetrameric interface [polypeptide binding]; other site
298654016808	NAD binding site [chemical binding]; other site
298654016809	catalytic residues [active]
298654016810	phenylhydantoinase; Validated; Region: PRK08323
298654016811	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
298654016812	tetramer interface [polypeptide binding]; other site
298654016813	active site
298654016814	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
298654016815	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
298654016816	active site
298654016817	catalytic triad [active]
298654016818	dimer interface [polypeptide binding]; other site
298654016819	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
298654016820	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654016821	DNA-binding site [nucleotide binding]; DNA binding site
298654016822	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654016823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654016824	homodimer interface [polypeptide binding]; other site
298654016825	catalytic residue [active]
298654016826	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654016827	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654016828	structural tetrad; other site
298654016829	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298654016830	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654016831	ligand binding site [chemical binding]; other site
298654016832	flexible hinge region; other site
298654016833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654016834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654016835	ATP binding site [chemical binding]; other site
298654016836	Mg2+ binding site [ion binding]; other site
298654016837	G-X-G motif; other site
298654016838	Response regulator receiver domain; Region: Response_reg; pfam00072
298654016839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654016840	active site
298654016841	phosphorylation site [posttranslational modification]
298654016842	intermolecular recognition site; other site
298654016843	dimerization interface [polypeptide binding]; other site
298654016844	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
298654016845	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654016846	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
298654016847	amphipathic channel; other site
298654016848	Asn-Pro-Ala signature motifs; other site
298654016849	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298654016850	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
298654016851	active site
298654016852	metal binding site [ion binding]; metal-binding site
298654016853	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654016854	active site
298654016855	ATP binding site [chemical binding]; other site
298654016856	substrate binding site [chemical binding]; other site
298654016857	activation loop (A-loop); other site
298654016858	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654016859	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654016860	structural tetrad; other site
298654016861	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654016862	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
298654016863	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654016864	active site
298654016865	ATP binding site [chemical binding]; other site
298654016866	substrate binding site [chemical binding]; other site
298654016867	activation loop (A-loop); other site
298654016868	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654016869	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654016870	structural tetrad; other site
298654016871	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654016872	Helix-turn-helix domain; Region: HTH_31; pfam13560
298654016873	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
298654016874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654016875	ATP binding site [chemical binding]; other site
298654016876	putative Mg++ binding site [ion binding]; other site
298654016877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654016878	nucleotide binding region [chemical binding]; other site
298654016879	ATP-binding site [chemical binding]; other site
298654016880	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
298654016881	HRDC domain; Region: HRDC; pfam00570
298654016882	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
298654016883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654016884	Walker A/P-loop; other site
298654016885	ATP binding site [chemical binding]; other site
298654016886	Q-loop/lid; other site
298654016887	ABC transporter signature motif; other site
298654016888	Walker B; other site
298654016889	D-loop; other site
298654016890	H-loop/switch region; other site
298654016891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654016892	dimer interface [polypeptide binding]; other site
298654016893	conserved gate region; other site
298654016894	putative PBP binding loops; other site
298654016895	ABC-ATPase subunit interface; other site
298654016896	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
298654016897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654016898	dimer interface [polypeptide binding]; other site
298654016899	conserved gate region; other site
298654016900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298654016901	ABC-ATPase subunit interface; other site
298654016902	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298654016903	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298654016904	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298654016905	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
298654016906	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
298654016907	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654016908	motif II; other site
298654016909	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
298654016910	dimer interface [polypeptide binding]; other site
298654016911	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
298654016912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654016913	putative metal binding site [ion binding]; other site
298654016914	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
298654016915	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654016916	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654016917	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298654016918	acyl-activating enzyme (AAE) consensus motif; other site
298654016919	AMP binding site [chemical binding]; other site
298654016920	active site
298654016921	CoA binding site [chemical binding]; other site
298654016922	Acyltransferase family; Region: Acyl_transf_3; pfam01757
298654016923	classical (c) SDRs; Region: SDR_c; cd05233
298654016924	NAD(P) binding site [chemical binding]; other site
298654016925	active site
298654016926	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
298654016927	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
298654016928	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654016929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654016930	active site
298654016931	phosphorylation site [posttranslational modification]
298654016932	intermolecular recognition site; other site
298654016933	dimerization interface [polypeptide binding]; other site
298654016934	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654016935	dimerization interface [polypeptide binding]; other site
298654016936	DNA binding residues [nucleotide binding]
298654016937	Histidine kinase; Region: HisKA_3; pfam07730
298654016938	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654016939	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654016940	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
298654016941	Walker A/P-loop; other site
298654016942	ATP binding site [chemical binding]; other site
298654016943	Q-loop/lid; other site
298654016944	ABC transporter signature motif; other site
298654016945	Walker B; other site
298654016946	D-loop; other site
298654016947	H-loop/switch region; other site
298654016948	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016949	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016950	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654016951	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654016952	NAD(P) binding site [chemical binding]; other site
298654016953	active site
298654016954	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654016955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654016956	putative substrate translocation pore; other site
298654016957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654016958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016959	FAD binding domain; Region: FAD_binding_4; pfam01565
298654016960	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
298654016961	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654016962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654016963	active site
298654016964	phosphorylation site [posttranslational modification]
298654016965	intermolecular recognition site; other site
298654016966	dimerization interface [polypeptide binding]; other site
298654016967	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654016968	DNA binding site [nucleotide binding]
298654016969	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654016970	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654016971	dimer interface [polypeptide binding]; other site
298654016972	phosphorylation site [posttranslational modification]
298654016973	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654016974	ATP binding site [chemical binding]; other site
298654016975	Mg2+ binding site [ion binding]; other site
298654016976	G-X-G motif; other site
298654016977	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654016978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654016979	Walker A/P-loop; other site
298654016980	ATP binding site [chemical binding]; other site
298654016981	Q-loop/lid; other site
298654016982	ABC transporter signature motif; other site
298654016983	Walker B; other site
298654016984	D-loop; other site
298654016985	H-loop/switch region; other site
298654016986	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
298654016987	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
298654016988	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
298654016989	GTP binding site; other site
298654016990	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
298654016991	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298654016992	SCP-2 sterol transfer family; Region: SCP2; pfam02036
298654016993	GAF domain; Region: GAF; pfam01590
298654016994	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654016995	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
298654016996	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654016997	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
298654016998	Subunit I/III interface [polypeptide binding]; other site
298654016999	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654017000	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
298654017001	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
298654017002	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
298654017003	Short C-terminal domain; Region: SHOCT; pfam09851
298654017004	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
298654017005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
298654017006	Cupin; Region: Cupin_6; pfam12852
298654017007	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654017008	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654017009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654017010	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654017011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654017012	NAD(P) binding site [chemical binding]; other site
298654017013	active site
298654017014	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
298654017015	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
298654017016	NAD binding site [chemical binding]; other site
298654017017	substrate binding site [chemical binding]; other site
298654017018	catalytic Zn binding site [ion binding]; other site
298654017019	structural Zn binding site [ion binding]; other site
298654017020	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
298654017021	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
298654017022	oligomer interface [polypeptide binding]; other site
298654017023	metal binding site [ion binding]; metal-binding site
298654017024	metal binding site [ion binding]; metal-binding site
298654017025	putative Cl binding site [ion binding]; other site
298654017026	aspartate ring; other site
298654017027	hydrophobic gate; other site
298654017028	periplasmic entrance; other site
298654017029	diaminopimelate decarboxylase; Region: lysA; TIGR01048
298654017030	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
298654017031	active site
298654017032	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298654017033	substrate binding site [chemical binding]; other site
298654017034	catalytic residues [active]
298654017035	dimer interface [polypeptide binding]; other site
298654017036	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
298654017037	active site
298654017038	catalytic site [active]
298654017039	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654017040	classical (c) SDRs; Region: SDR_c; cd05233
298654017041	NAD(P) binding site [chemical binding]; other site
298654017042	active site
298654017043	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654017044	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298654017045	NAD(P) binding site [chemical binding]; other site
298654017046	catalytic residues [active]
298654017047	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654017048	Cytochrome P450; Region: p450; cl12078
298654017049	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298654017050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654017051	DNA-binding site [nucleotide binding]; DNA binding site
298654017052	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654017053	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654017054	Cytochrome P450; Region: p450; cl12078
298654017055	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654017056	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654017057	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654017058	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654017059	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654017060	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654017061	Cytochrome P450; Region: p450; cl12078
298654017062	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654017063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654017064	NAD(P) binding site [chemical binding]; other site
298654017065	active site
298654017066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654017067	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654017068	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654017069	classical (c) SDRs; Region: SDR_c; cd05233
298654017070	NAD(P) binding site [chemical binding]; other site
298654017071	active site
298654017072	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
298654017073	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654017074	putative active site [active]
298654017075	putative metal binding site [ion binding]; other site
298654017076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654017077	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
298654017078	SmpB-tmRNA interface; other site
298654017079	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
298654017080	FtsX-like permease family; Region: FtsX; pfam02687
298654017081	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
298654017082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654017083	Walker A/P-loop; other site
298654017084	ATP binding site [chemical binding]; other site
298654017085	Q-loop/lid; other site
298654017086	ABC transporter signature motif; other site
298654017087	Walker B; other site
298654017088	D-loop; other site
298654017089	H-loop/switch region; other site
298654017090	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
298654017091	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
298654017092	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
298654017093	homodimer interface [polypeptide binding]; other site
298654017094	active site
298654017095	SAM binding site [chemical binding]; other site
298654017096	peptide chain release factor 2; Validated; Region: prfB; PRK00578
298654017097	This domain is found in peptide chain release factors; Region: PCRF; smart00937
298654017098	RF-1 domain; Region: RF-1; pfam00472
298654017099	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
298654017100	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298654017101	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
298654017102	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
298654017103	ATP binding site [chemical binding]; other site
298654017104	Walker A motif; other site
298654017105	hexamer interface [polypeptide binding]; other site
298654017106	Walker B motif; other site
298654017107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654017108	PAS fold; Region: PAS_3; pfam08447
298654017109	putative active site [active]
298654017110	heme pocket [chemical binding]; other site
298654017111	Uncharacterized conserved protein [Function unknown]; Region: COG3743
298654017112	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654017113	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654017114	non-specific DNA binding site [nucleotide binding]; other site
298654017115	salt bridge; other site
298654017116	sequence-specific DNA binding site [nucleotide binding]; other site
298654017117	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
298654017118	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
298654017119	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
298654017120	Helix-turn-helix domain; Region: HTH_17; pfam12728
298654017121	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298654017122	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
298654017123	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
298654017124	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
298654017125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
298654017126	nucleotide binding region [chemical binding]; other site
298654017127	SEC-C motif; Region: SEC-C; pfam02810
298654017128	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654017129	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654017130	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654017131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654017132	active site
298654017133	phosphorylation site [posttranslational modification]
298654017134	intermolecular recognition site; other site
298654017135	dimerization interface [polypeptide binding]; other site
298654017136	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654017137	DNA binding residues [nucleotide binding]
298654017138	dimerization interface [polypeptide binding]; other site
298654017139	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
298654017140	30S subunit binding site; other site
298654017141	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
298654017142	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
298654017143	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654017144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298654017145	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654017146	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654017147	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654017148	hydrophobic ligand binding site; other site
298654017149	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
298654017150	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
298654017151	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
298654017152	catalytic site [active]
298654017153	active site
298654017154	Integral membrane protein DUF95; Region: DUF95; pfam01944
298654017155	Predicted membrane protein/domain [Function unknown]; Region: COG1714
298654017156	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
298654017157	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
298654017158	homotetramer interface [polypeptide binding]; other site
298654017159	ligand binding site [chemical binding]; other site
298654017160	catalytic site [active]
298654017161	NAD binding site [chemical binding]; other site
298654017162	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654017163	DNA binding residues [nucleotide binding]
298654017164	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654017165	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
298654017166	Transglycosylase; Region: Transgly; pfam00912
298654017167	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
298654017168	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
298654017169	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
298654017170	dimer interface [polypeptide binding]; other site
298654017171	active site
298654017172	Trm112p-like protein; Region: Trm112p; cl01066
298654017173	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
298654017174	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
298654017175	active site
298654017176	substrate binding site [chemical binding]; other site
298654017177	metal binding site [ion binding]; metal-binding site
298654017178	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
298654017179	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
298654017180	Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238
298654017181	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
298654017182	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
298654017183	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654017184	Transcription factor WhiB; Region: Whib; pfam02467
298654017185	FO synthase; Reviewed; Region: fbiC; PRK09234
298654017186	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654017187	FeS/SAM binding site; other site
298654017188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654017189	FeS/SAM binding site; other site
298654017190	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654017191	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654017192	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
298654017193	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
298654017194	phosphate binding site [ion binding]; other site
298654017195	dimer interface [polypeptide binding]; other site
298654017196	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
298654017197	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
298654017198	F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553
298654017199	FMN binding site [chemical binding]; other site
298654017200	dimer interface [polypeptide binding]; other site
298654017201	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
298654017202	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
298654017203	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
298654017204	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
298654017205	active site
298654017206	Substrate binding site; other site
298654017207	Mg++ binding site; other site
298654017208	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
298654017209	putative trimer interface [polypeptide binding]; other site
298654017210	putative CoA binding site [chemical binding]; other site
298654017211	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654017212	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
298654017213	Probable Catalytic site; other site
298654017214	metal-binding site
298654017215	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
298654017216	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
298654017217	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654017218	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654017219	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
298654017220	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654017221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654017222	S-adenosylmethionine binding site [chemical binding]; other site
298654017223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654017224	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654017225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654017226	S-adenosylmethionine binding site [chemical binding]; other site
298654017227	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
298654017228	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654017229	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298654017230	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
298654017231	Ligand binding site; other site
298654017232	Putative Catalytic site; other site
298654017233	DXD motif; other site
298654017234	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
298654017235	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
298654017236	trimer interface [polypeptide binding]; other site
298654017237	active site
298654017238	substrate binding site [chemical binding]; other site
298654017239	CoA binding site [chemical binding]; other site
298654017240	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
298654017241	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654017242	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654017243	active site
298654017244	ATP binding site [chemical binding]; other site
298654017245	substrate binding site [chemical binding]; other site
298654017246	activation loop (A-loop); other site
298654017247	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654017248	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654017249	structural tetrad; other site
298654017250	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
298654017251	homodimer interface [polypeptide binding]; other site
298654017252	metal binding site [ion binding]; metal-binding site
298654017253	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
298654017254	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298654017255	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
298654017256	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
298654017257	Walker A/P-loop; other site
298654017258	ATP binding site [chemical binding]; other site
298654017259	Q-loop/lid; other site
298654017260	ABC transporter signature motif; other site
298654017261	Walker B; other site
298654017262	D-loop; other site
298654017263	H-loop/switch region; other site
298654017264	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654017265	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
298654017266	Probable Catalytic site; other site
298654017267	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
298654017268	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654017269	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654017270	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654017271	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
298654017272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298654017273	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654017274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654017275	YCII-related domain; Region: YCII; cl00999
298654017276	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
298654017277	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654017278	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654017279	NAD(P) binding site [chemical binding]; other site
298654017280	active site
298654017281	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
298654017282	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298654017283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654017284	putative substrate translocation pore; other site
298654017285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654017286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654017287	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654017288	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654017289	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654017290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654017291	putative substrate translocation pore; other site
298654017292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654017293	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
298654017294	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
298654017295	active site
298654017296	HIGH motif; other site
298654017297	KMSKS motif; other site
298654017298	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
298654017299	tRNA binding surface [nucleotide binding]; other site
298654017300	anticodon binding site; other site
298654017301	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
298654017302	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
298654017303	NADP binding site [chemical binding]; other site
298654017304	active site
298654017305	putative substrate binding site [chemical binding]; other site
298654017306	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
298654017307	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
298654017308	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
298654017309	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
298654017310	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
298654017311	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
298654017312	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
298654017313	TIGR03089 family protein; Region: TIGR03089
298654017314	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
298654017315	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
298654017316	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
298654017317	GtrA-like protein; Region: GtrA; pfam04138
298654017318	Predicted membrane protein [Function unknown]; Region: COG2246
298654017319	Bacterial PH domain; Region: DUF304; pfam03703
298654017320	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
298654017321	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
298654017322	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
298654017323	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
298654017324	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298654017325	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654017326	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
298654017327	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654017328	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
298654017329	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
298654017330	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654017331	carboxyltransferase (CT) interaction site; other site
298654017332	biotinylation site [posttranslational modification]; other site
298654017333	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
298654017334	putative active site pocket [active]
298654017335	dimerization interface [polypeptide binding]; other site
298654017336	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
298654017337	putative catalytic residue [active]
298654017338	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
298654017339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654017340	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654017341	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298654017342	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
298654017343	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
298654017344	metal binding site [ion binding]; metal-binding site
298654017345	putative dimer interface [polypeptide binding]; other site
298654017346	carboxylate-amine ligase; Provisional; Region: PRK13517
298654017347	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
298654017348	Clp amino terminal domain; Region: Clp_N; pfam02861
298654017349	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
298654017350	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
298654017351	dimer interface [polypeptide binding]; other site
298654017352	anticodon binding site; other site
298654017353	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298654017354	motif 1; other site
298654017355	dimer interface [polypeptide binding]; other site
298654017356	active site
298654017357	motif 2; other site
298654017358	GAD domain; Region: GAD; pfam02938
298654017359	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298654017360	active site
298654017361	motif 3; other site
298654017362	purine nucleoside phosphorylase; Provisional; Region: PRK08202
298654017363	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
298654017364	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
298654017365	active site
298654017366	substrate binding site [chemical binding]; other site
298654017367	metal binding site [ion binding]; metal-binding site
298654017368	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654017369	active site
298654017370	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
298654017371	intersubunit interface [polypeptide binding]; other site
298654017372	active site
298654017373	catalytic residue [active]
298654017374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654017375	Histidine kinase; Region: HisKA_3; pfam07730
298654017376	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654017377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654017378	active site
298654017379	phosphorylation site [posttranslational modification]
298654017380	intermolecular recognition site; other site
298654017381	dimerization interface [polypeptide binding]; other site
298654017382	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654017383	DNA binding residues [nucleotide binding]
298654017384	dimerization interface [polypeptide binding]; other site
298654017385	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
298654017386	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298654017387	adenosine deaminase; Provisional; Region: PRK09358
298654017388	active site
298654017389	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654017390	Protein kinase domain; Region: Pkinase; pfam00069
298654017391	active site
298654017392	ATP binding site [chemical binding]; other site
298654017393	substrate binding site [chemical binding]; other site
298654017394	activation loop (A-loop); other site
298654017395	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654017396	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654017397	active site
298654017398	ATP binding site [chemical binding]; other site
298654017399	substrate binding site [chemical binding]; other site
298654017400	activation loop (A-loop); other site
298654017401	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654017402	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654017403	Coenzyme A binding pocket [chemical binding]; other site
298654017404	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654017405	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
298654017406	putative Mg++ binding site [ion binding]; other site
298654017407	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654017408	nucleotide binding region [chemical binding]; other site
298654017409	ATP-binding site [chemical binding]; other site
298654017410	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
298654017411	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654017412	active site
298654017413	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
298654017414	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
298654017415	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
298654017416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654017417	Coenzyme A binding pocket [chemical binding]; other site
298654017418	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
298654017419	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298654017420	Beta-lactamase; Region: Beta-lactamase; pfam00144
298654017421	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
298654017422	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
298654017423	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
298654017424	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
298654017425	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
298654017426	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
298654017427	purine monophosphate binding site [chemical binding]; other site
298654017428	dimer interface [polypeptide binding]; other site
298654017429	putative catalytic residues [active]
298654017430	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
298654017431	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
298654017432	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
298654017433	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
298654017434	active site
298654017435	substrate binding site [chemical binding]; other site
298654017436	cosubstrate binding site; other site
298654017437	catalytic site [active]
298654017438	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654017439	salt bridge; other site
298654017440	non-specific DNA binding site [nucleotide binding]; other site
298654017441	sequence-specific DNA binding site [nucleotide binding]; other site
298654017442	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
298654017443	CoA binding domain; Region: CoA_binding; smart00881
298654017444	CoA-ligase; Region: Ligase_CoA; pfam00549
298654017445	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
298654017446	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
298654017447	CoA-ligase; Region: Ligase_CoA; pfam00549
298654017448	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654017449	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654017450	active site
298654017451	ATP binding site [chemical binding]; other site
298654017452	substrate binding site [chemical binding]; other site
298654017453	activation loop (A-loop); other site
298654017454	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
298654017455	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
298654017456	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298654017457	PGAP1-like protein; Region: PGAP1; pfam07819
298654017458	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654017459	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
298654017460	oligomerisation interface [polypeptide binding]; other site
298654017461	mobile loop; other site
298654017462	roof hairpin; other site
298654017463	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
298654017464	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
298654017465	ring oligomerisation interface [polypeptide binding]; other site
298654017466	ATP/Mg binding site [chemical binding]; other site
298654017467	stacking interactions; other site
298654017468	hinge regions; other site
298654017469	Transcription factor WhiB; Region: Whib; pfam02467
298654017470	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
298654017471	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654017472	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
298654017473	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
298654017474	active site
298654017475	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
298654017476	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298654017477	phosphate binding site [ion binding]; other site
298654017478	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
298654017479	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654017480	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654017481	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298654017482	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
298654017483	G1 box; other site
298654017484	GTP/Mg2+ binding site [chemical binding]; other site
298654017485	G2 box; other site
298654017486	Switch I region; other site
298654017487	G3 box; other site
298654017488	Switch II region; other site
298654017489	G4 box; other site
298654017490	G5 box; other site
298654017491	Protein of unknown function (DUF742); Region: DUF742; pfam05331
298654017492	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
298654017493	Nitrate and nitrite sensing; Region: NIT; pfam08376
298654017494	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654017495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654017496	ATP binding site [chemical binding]; other site
298654017497	Mg2+ binding site [ion binding]; other site
298654017498	G-X-G motif; other site
298654017499	GMP synthase; Reviewed; Region: guaA; PRK00074
298654017500	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
298654017501	AMP/PPi binding site [chemical binding]; other site
298654017502	candidate oxyanion hole; other site
298654017503	catalytic triad [active]
298654017504	potential glutamine specificity residues [chemical binding]; other site
298654017505	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
298654017506	ATP Binding subdomain [chemical binding]; other site
298654017507	Ligand Binding sites [chemical binding]; other site
298654017508	Dimerization subdomain; other site
298654017509	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
298654017510	Part of AAA domain; Region: AAA_19; pfam13245
298654017511	Family description; Region: UvrD_C_2; pfam13538
298654017512	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654017513	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654017514	TAP-like protein; Region: Abhydrolase_4; pfam08386
298654017515	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
298654017516	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
298654017517	putative substrate binding site [chemical binding]; other site
298654017518	putative ATP binding site [chemical binding]; other site
298654017519	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
298654017520	hypothetical protein; Provisional; Region: PRK06815
298654017521	tetramer interface [polypeptide binding]; other site
298654017522	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654017523	catalytic residue [active]
298654017524	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
298654017525	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
298654017526	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
298654017527	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654017528	Coenzyme A binding pocket [chemical binding]; other site
298654017529	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
298654017530	Glycoprotease family; Region: Peptidase_M22; pfam00814
298654017531	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
298654017532	alanine racemase; Reviewed; Region: alr; PRK00053
298654017533	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
298654017534	active site
298654017535	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298654017536	dimer interface [polypeptide binding]; other site
298654017537	substrate binding site [chemical binding]; other site
298654017538	catalytic residues [active]
298654017539	Uncharacterized conserved protein [Function unknown]; Region: COG4715
298654017540	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
298654017541	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
298654017542	glutaminase active site [active]
298654017543	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
298654017544	dimer interface [polypeptide binding]; other site
298654017545	active site
298654017546	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
298654017547	dimer interface [polypeptide binding]; other site
298654017548	active site
298654017549	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
298654017550	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
298654017551	active site
298654017552	substrate binding site [chemical binding]; other site
298654017553	metal binding site [ion binding]; metal-binding site
298654017554	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
298654017555	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
298654017556	23S rRNA interface [nucleotide binding]; other site
298654017557	L3 interface [polypeptide binding]; other site
298654017558	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
298654017559	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
298654017560	dimerization interface 3.5A [polypeptide binding]; other site
298654017561	active site
298654017562	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
298654017563	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
298654017564	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
298654017565	alphaNTD - beta interaction site [polypeptide binding]; other site
298654017566	alphaNTD homodimer interface [polypeptide binding]; other site
298654017567	alphaNTD - beta' interaction site [polypeptide binding]; other site
298654017568	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
298654017569	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
298654017570	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
298654017571	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298654017572	RNA binding surface [nucleotide binding]; other site
298654017573	30S ribosomal protein S11; Validated; Region: PRK05309
298654017574	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
298654017575	30S ribosomal protein S13; Region: bact_S13; TIGR03631
298654017576	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
298654017577	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
298654017578	rRNA binding site [nucleotide binding]; other site
298654017579	predicted 30S ribosome binding site; other site
298654017580	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
298654017581	active site
298654017582	adenylate kinase; Reviewed; Region: adk; PRK00279
298654017583	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
298654017584	AMP-binding site [chemical binding]; other site
298654017585	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
298654017586	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
298654017587	SecY translocase; Region: SecY; pfam00344
298654017588	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
298654017589	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
298654017590	23S rRNA binding site [nucleotide binding]; other site
298654017591	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
298654017592	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
298654017593	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
298654017594	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
298654017595	23S rRNA interface [nucleotide binding]; other site
298654017596	5S rRNA interface [nucleotide binding]; other site
298654017597	L27 interface [polypeptide binding]; other site
298654017598	L5 interface [polypeptide binding]; other site
298654017599	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
298654017600	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
298654017601	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
298654017602	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
298654017603	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
298654017604	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
298654017605	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
298654017606	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
298654017607	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
298654017608	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
298654017609	RNA binding site [nucleotide binding]; other site
298654017610	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
298654017611	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
298654017612	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
298654017613	putative translocon interaction site; other site
298654017614	23S rRNA interface [nucleotide binding]; other site
298654017615	signal recognition particle (SRP54) interaction site; other site
298654017616	L23 interface [polypeptide binding]; other site
298654017617	trigger factor interaction site; other site
298654017618	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
298654017619	23S rRNA interface [nucleotide binding]; other site
298654017620	5S rRNA interface [nucleotide binding]; other site
298654017621	putative antibiotic binding site [chemical binding]; other site
298654017622	L25 interface [polypeptide binding]; other site
298654017623	L27 interface [polypeptide binding]; other site
298654017624	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
298654017625	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
298654017626	G-X-X-G motif; other site
298654017627	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
298654017628	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
298654017629	putative translocon binding site; other site
298654017630	protein-rRNA interface [nucleotide binding]; other site
298654017631	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
298654017632	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
298654017633	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
298654017634	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
298654017635	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
298654017636	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
298654017637	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
298654017638	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
298654017639	elongation factor Tu; Reviewed; Region: PRK00049
298654017640	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
298654017641	G1 box; other site
298654017642	GEF interaction site [polypeptide binding]; other site
298654017643	GTP/Mg2+ binding site [chemical binding]; other site
298654017644	Switch I region; other site
298654017645	G2 box; other site
298654017646	G3 box; other site
298654017647	Switch II region; other site
298654017648	G4 box; other site
298654017649	G5 box; other site
298654017650	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
298654017651	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
298654017652	Antibiotic Binding Site [chemical binding]; other site
298654017653	elongation factor G; Reviewed; Region: PRK00007
298654017654	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
298654017655	G1 box; other site
298654017656	putative GEF interaction site [polypeptide binding]; other site
298654017657	GTP/Mg2+ binding site [chemical binding]; other site
298654017658	Switch I region; other site
298654017659	G2 box; other site
298654017660	G3 box; other site
298654017661	Switch II region; other site
298654017662	G4 box; other site
298654017663	G5 box; other site
298654017664	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
298654017665	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
298654017666	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
298654017667	30S ribosomal protein S7; Validated; Region: PRK05302
298654017668	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
298654017669	S17 interaction site [polypeptide binding]; other site
298654017670	S8 interaction site; other site
298654017671	16S rRNA interaction site [nucleotide binding]; other site
298654017672	streptomycin interaction site [chemical binding]; other site
298654017673	23S rRNA interaction site [nucleotide binding]; other site
298654017674	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
298654017675	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
298654017676	active site
298654017677	SUMO-1 interface [polypeptide binding]; other site
298654017678	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
298654017679	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
298654017680	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
298654017681	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
298654017682	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
298654017683	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
298654017684	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
298654017685	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
298654017686	G-loop; other site
298654017687	DNA binding site [nucleotide binding]
298654017688	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
298654017689	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
298654017690	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
298654017691	RPB1 interaction site [polypeptide binding]; other site
298654017692	RPB10 interaction site [polypeptide binding]; other site
298654017693	RPB11 interaction site [polypeptide binding]; other site
298654017694	RPB3 interaction site [polypeptide binding]; other site
298654017695	RPB12 interaction site [polypeptide binding]; other site
298654017696	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
298654017697	peripheral dimer interface [polypeptide binding]; other site
298654017698	core dimer interface [polypeptide binding]; other site
298654017699	L10 interface [polypeptide binding]; other site
298654017700	L11 interface [polypeptide binding]; other site
298654017701	putative EF-Tu interaction site [polypeptide binding]; other site
298654017702	putative EF-G interaction site [polypeptide binding]; other site
298654017703	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
298654017704	23S rRNA interface [nucleotide binding]; other site
298654017705	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
298654017706	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
298654017707	mRNA/rRNA interface [nucleotide binding]; other site
298654017708	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
298654017709	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
298654017710	23S rRNA interface [nucleotide binding]; other site
298654017711	L7/L12 interface [polypeptide binding]; other site
298654017712	putative thiostrepton binding site; other site
298654017713	L25 interface [polypeptide binding]; other site
298654017714	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
298654017715	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
298654017716	putative homodimer interface [polypeptide binding]; other site
298654017717	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
298654017718	heterodimer interface [polypeptide binding]; other site
298654017719	homodimer interface [polypeptide binding]; other site
298654017720	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
298654017721	aspartate aminotransferase; Provisional; Region: PRK05764
298654017722	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654017723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654017724	homodimer interface [polypeptide binding]; other site
298654017725	catalytic residue [active]
298654017726	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
298654017727	active site
298654017728	catalytic site [active]
298654017729	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
298654017730	active site
298654017731	catalytic site [active]
298654017732	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
298654017733	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
298654017734	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
298654017735	active site
298654017736	LGFP repeat; Region: LGFP; pfam08310
298654017737	LGFP repeat; Region: LGFP; pfam08310
298654017738	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
298654017739	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654017740	active site
298654017741	motif I; other site
298654017742	motif II; other site
298654017743	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654017744	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
298654017745	putative active site pocket [active]
298654017746	dimerization interface [polypeptide binding]; other site
298654017747	putative catalytic residue [active]
298654017748	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654017749	active site
298654017750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
298654017751	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
298654017752	heat shock protein HtpX; Provisional; Region: PRK03072
298654017753	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
298654017754	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
298654017755	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
298654017756	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
298654017757	dimer interface [polypeptide binding]; other site
298654017758	PYR/PP interface [polypeptide binding]; other site
298654017759	TPP binding site [chemical binding]; other site
298654017760	substrate binding site [chemical binding]; other site
298654017761	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
298654017762	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
298654017763	TPP-binding site [chemical binding]; other site
298654017764	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
298654017765	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
298654017766	substrate binding pocket [chemical binding]; other site
298654017767	chain length determination region; other site
298654017768	substrate-Mg2+ binding site; other site
298654017769	catalytic residues [active]
298654017770	aspartate-rich region 1; other site
298654017771	active site lid residues [active]
298654017772	aspartate-rich region 2; other site
298654017773	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
298654017774	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
298654017775	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
298654017776	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
298654017777	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
298654017778	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
298654017779	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
298654017780	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
298654017781	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
298654017782	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
298654017783	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
298654017784	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
298654017785	4Fe-4S binding domain; Region: Fer4; pfam00037
298654017786	4Fe-4S binding domain; Region: Fer4; pfam00037
298654017787	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
298654017788	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
298654017789	NADH dehydrogenase subunit G; Validated; Region: PRK07860
298654017790	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654017791	catalytic loop [active]
298654017792	iron binding site [ion binding]; other site
298654017793	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
298654017794	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
298654017795	molybdopterin cofactor binding site; other site
298654017796	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
298654017797	molybdopterin cofactor binding site; other site
298654017798	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
298654017799	SLBB domain; Region: SLBB; pfam10531
298654017800	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
298654017801	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
298654017802	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
298654017803	putative dimer interface [polypeptide binding]; other site
298654017804	[2Fe-2S] cluster binding site [ion binding]; other site
298654017805	NADH dehydrogenase subunit D; Validated; Region: PRK06075
298654017806	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
298654017807	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
298654017808	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
298654017809	NADH dehydrogenase subunit B; Validated; Region: PRK06411
298654017810	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
298654017811	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
298654017812	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
298654017813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654017814	S-adenosylmethionine binding site [chemical binding]; other site
298654017815	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
298654017816	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654017817	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654017818	active site
298654017819	ATP binding site [chemical binding]; other site
298654017820	substrate binding site [chemical binding]; other site
298654017821	activation loop (A-loop); other site
298654017822	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
298654017823	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654017824	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
298654017825	putative active site [active]
298654017826	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
298654017827	active site
298654017828	SAM binding site [chemical binding]; other site
298654017829	homodimer interface [polypeptide binding]; other site
298654017830	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
298654017831	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298654017832	Active Sites [active]
298654017833	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
298654017834	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298654017835	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298654017836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654017837	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654017838	active site
298654017839	phosphorylation site [posttranslational modification]
298654017840	intermolecular recognition site; other site
298654017841	dimerization interface [polypeptide binding]; other site
298654017842	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654017843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654017844	non-specific DNA binding site [nucleotide binding]; other site
298654017845	salt bridge; other site
298654017846	sequence-specific DNA binding site [nucleotide binding]; other site
298654017847	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
298654017848	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
298654017849	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654017850	FeS/SAM binding site; other site
298654017851	aromatic acid decarboxylase; Validated; Region: PRK05920
298654017852	Flavoprotein; Region: Flavoprotein; pfam02441
298654017853	prenyltransferase; Reviewed; Region: ubiA; PRK12888
298654017854	UbiA prenyltransferase family; Region: UbiA; pfam01040
298654017855	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
298654017856	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
298654017857	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
298654017858	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
298654017859	ResB-like family; Region: ResB; pfam05140
298654017860	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
298654017861	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
298654017862	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
298654017863	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298654017864	catalytic residues [active]
298654017865	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654017866	catalytic core [active]
298654017867	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
298654017868	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298654017869	inhibitor-cofactor binding pocket; inhibition site
298654017870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654017871	catalytic residue [active]
298654017872	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
298654017873	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654017874	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
298654017875	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
298654017876	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
298654017877	active site
298654017878	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298654017879	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654017880	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654017881	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
298654017882	Walker A/P-loop; other site
298654017883	ATP binding site [chemical binding]; other site
298654017884	Q-loop/lid; other site
298654017885	ABC transporter signature motif; other site
298654017886	Walker B; other site
298654017887	D-loop; other site
298654017888	H-loop/switch region; other site
298654017889	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
298654017890	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
298654017891	metal-binding site [ion binding]
298654017892	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
298654017893	Soluble P-type ATPase [General function prediction only]; Region: COG4087
298654017894	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
298654017895	metal-binding site [ion binding]
298654017896	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
298654017897	dimer interface [polypeptide binding]; other site
298654017898	active site
298654017899	Schiff base residues; other site
298654017900	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
298654017901	homodimer interface [polypeptide binding]; other site
298654017902	active site
298654017903	SAM binding site [chemical binding]; other site
298654017904	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
298654017905	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
298654017906	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
298654017907	active site
298654017908	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
298654017909	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
298654017910	domain interfaces; other site
298654017911	active site
298654017912	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
298654017913	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
298654017914	tRNA; other site
298654017915	putative tRNA binding site [nucleotide binding]; other site
298654017916	putative NADP binding site [chemical binding]; other site
298654017917	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
298654017918	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
298654017919	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
298654017920	CoA binding domain; Region: CoA_binding; pfam02629
298654017921	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
298654017922	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
298654017923	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654017924	motif II; other site
298654017925	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298654017926	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
298654017927	putative acyl-acceptor binding pocket; other site
298654017928	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654017929	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
298654017930	putative NAD(P) binding site [chemical binding]; other site
298654017931	active site
298654017932	putative substrate binding site [chemical binding]; other site
298654017933	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
298654017934	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
298654017935	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
298654017936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654017937	Methyltransferase domain; Region: Methyltransf_31; pfam13847
298654017938	S-adenosylmethionine binding site [chemical binding]; other site
298654017939	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
298654017940	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298654017941	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
298654017942	Metal-binding active site; metal-binding site
298654017943	exopolyphosphatase; Region: exo_poly_only; TIGR03706
298654017944	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
298654017945	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654017946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654017947	active site
298654017948	phosphorylation site [posttranslational modification]
298654017949	intermolecular recognition site; other site
298654017950	dimerization interface [polypeptide binding]; other site
298654017951	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654017952	DNA binding site [nucleotide binding]
298654017953	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
298654017954	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654017955	dimer interface [polypeptide binding]; other site
298654017956	phosphorylation site [posttranslational modification]
298654017957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654017958	ATP binding site [chemical binding]; other site
298654017959	Mg2+ binding site [ion binding]; other site
298654017960	G-X-G motif; other site
298654017961	PhoU domain; Region: PhoU; pfam01895
298654017962	PhoU domain; Region: PhoU; pfam01895
298654017963	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654017964	catalytic core [active]
298654017965	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654017966	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
298654017967	homodimer interface [polypeptide binding]; other site
298654017968	substrate-cofactor binding pocket; other site
298654017969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654017970	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
298654017971	catalytic residue [active]
298654017972	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
298654017973	metal binding site 2 [ion binding]; metal-binding site
298654017974	putative DNA binding helix; other site
298654017975	metal binding site 1 [ion binding]; metal-binding site
298654017976	dimer interface [polypeptide binding]; other site
298654017977	structural Zn2+ binding site [ion binding]; other site
298654017978	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
298654017979	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
298654017980	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
298654017981	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
298654017982	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654017983	Walker A/P-loop; other site
298654017984	ATP binding site [chemical binding]; other site
298654017985	Q-loop/lid; other site
298654017986	ABC transporter signature motif; other site
298654017987	Walker B; other site
298654017988	D-loop; other site
298654017989	H-loop/switch region; other site
298654017990	TOBE domain; Region: TOBE; pfam03459
298654017991	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
298654017992	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654017993	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654017994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654017995	dimer interface [polypeptide binding]; other site
298654017996	conserved gate region; other site
298654017997	putative PBP binding loops; other site
298654017998	ABC-ATPase subunit interface; other site
298654017999	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654018000	dimer interface [polypeptide binding]; other site
298654018001	conserved gate region; other site
298654018002	putative PBP binding loops; other site
298654018003	ABC-ATPase subunit interface; other site
298654018004	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
298654018005	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
298654018006	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
298654018007	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654018008	non-specific DNA binding site [nucleotide binding]; other site
298654018009	salt bridge; other site
298654018010	sequence-specific DNA binding site [nucleotide binding]; other site
298654018011	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654018012	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654018013	active site
298654018014	catalytic tetrad [active]
298654018015	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
298654018016	putative ADP-ribose binding site [chemical binding]; other site
298654018017	putative active site [active]
298654018018	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
298654018019	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
298654018020	putative ADP-binding pocket [chemical binding]; other site
298654018021	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
298654018022	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
298654018023	heme-binding site [chemical binding]; other site
298654018024	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298654018025	catalytic residues [active]
298654018026	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
298654018027	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
298654018028	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
298654018029	active site residue [active]
298654018030	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
298654018031	active site residue [active]
298654018032	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
298654018033	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
298654018034	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
298654018035	Ubiquitin-like proteins; Region: UBQ; cl00155
298654018036	charged pocket; other site
298654018037	hydrophobic patch; other site
298654018038	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654018039	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654018040	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654018041	DNA binding site [nucleotide binding]
298654018042	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
298654018043	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654018044	Coenzyme A binding pocket [chemical binding]; other site
298654018045	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298654018046	anti sigma factor interaction site; other site
298654018047	regulatory phosphorylation site [posttranslational modification]; other site
298654018048	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
298654018049	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
298654018050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
298654018051	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
298654018052	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
298654018053	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654018054	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
298654018055	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
298654018056	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
298654018057	Imelysin; Region: Peptidase_M75; pfam09375
298654018058	Iron permease FTR1 family; Region: FTR1; cl00475
298654018059	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
298654018060	hypothetical protein; Provisional; Region: PRK07907
298654018061	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
298654018062	active site
298654018063	metal binding site [ion binding]; metal-binding site
298654018064	dimer interface [polypeptide binding]; other site
298654018065	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654018066	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654018067	structural tetrad; other site
298654018068	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654018069	DNA binding residues [nucleotide binding]
298654018070	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654018071	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
298654018072	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654018073	DNA binding residues [nucleotide binding]
298654018074	dimer interface [polypeptide binding]; other site
298654018075	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
298654018076	Clp protease; Region: CLP_protease; pfam00574
298654018077	oligomer interface [polypeptide binding]; other site
298654018078	active site residues [active]
298654018079	Cupin domain; Region: Cupin_2; cl17218
298654018080	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654018081	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654018082	non-specific DNA binding site [nucleotide binding]; other site
298654018083	salt bridge; other site
298654018084	sequence-specific DNA binding site [nucleotide binding]; other site
298654018085	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298654018086	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654018087	active site
298654018088	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298654018089	PII uridylyl-transferase; Provisional; Region: PRK03381
298654018090	metal binding triad; other site
298654018091	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
298654018092	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
298654018093	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
298654018094	Nitrogen regulatory protein P-II; Region: P-II; smart00938
298654018095	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
298654018096	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298654018097	NlpC/P60 family; Region: NLPC_P60; pfam00877
298654018098	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
298654018099	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
298654018100	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
298654018101	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
298654018102	FeoA domain; Region: FeoA; cl00838
298654018103	AAA ATPase domain; Region: AAA_16; pfam13191
298654018104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018105	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018106	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018107	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018108	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018109	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018110	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018111	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018112	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018113	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018114	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018115	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018116	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018117	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018118	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018119	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018120	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018121	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018122	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654018123	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654018124	active site
298654018125	ATP binding site [chemical binding]; other site
298654018126	substrate binding site [chemical binding]; other site
298654018127	activation loop (A-loop); other site
298654018128	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298654018129	Ligand Binding Site [chemical binding]; other site
298654018130	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
298654018131	putative dimer interface [polypeptide binding]; other site
298654018132	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654018133	ligand binding site [chemical binding]; other site
298654018134	Zn binding site [ion binding]; other site
298654018135	UreE urease accessory protein, C-terminal domain; Region: UreE_C; smart00987
298654018136	ligand binding site [chemical binding]; other site
298654018137	active site
298654018138	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
298654018139	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654018140	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654018141	TIR domain; Region: TIR_2; pfam13676
298654018142	WD40 repeats; Region: WD40; smart00320
298654018143	PQQ-like domain; Region: PQQ_2; pfam13360
298654018144	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654018145	structural tetrad; other site
298654018146	Predicted esterase [General function prediction only]; Region: COG0627
298654018147	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
298654018148	classical (c) SDRs; Region: SDR_c; cd05233
298654018149	NAD(P) binding site [chemical binding]; other site
298654018150	active site
298654018151	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298654018152	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298654018153	active site
298654018154	catalytic tetrad [active]
298654018155	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018156	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018157	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298654018158	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
298654018159	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298654018160	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298654018161	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654018162	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654018163	putative ligand binding site [chemical binding]; other site
298654018164	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654018165	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654018166	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654018167	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654018168	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018170	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
298654018171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654018172	NAD(P) binding site [chemical binding]; other site
298654018173	active site
298654018174	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
298654018175	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654018176	catalytic Zn binding site [ion binding]; other site
298654018177	NAD(P) binding site [chemical binding]; other site
298654018178	structural Zn binding site [ion binding]; other site
298654018179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654018180	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654018181	Coenzyme A binding pocket [chemical binding]; other site
298654018182	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
298654018183	active site
298654018184	catalytic triad [active]
298654018185	oxyanion hole [active]
298654018186	Protein of unknown function DUF72; Region: DUF72; pfam01904
298654018187	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654018188	Helix-turn-helix domain; Region: HTH_17; cl17695
298654018189	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654018190	Transcription factor WhiB; Region: Whib; pfam02467
298654018191	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
298654018192	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
298654018193	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654018194	active site
298654018195	DNA binding site [nucleotide binding]
298654018196	Int/Topo IB signature motif; other site
298654018197	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
298654018198	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
298654018199	AAA domain; Region: AAA_25; pfam13481
298654018200	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298654018201	Walker A motif; other site
298654018202	ATP binding site [chemical binding]; other site
298654018203	Walker B motif; other site
298654018204	Helix-turn-helix domain; Region: HTH_17; cl17695
298654018205	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654018206	active site
298654018207	Int/Topo IB signature motif; other site
298654018208	DNA binding site [nucleotide binding]
298654018209	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654018210	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
298654018211	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654018212	Proteins of 100 residues with WXG; Region: WXG100; cl02005
298654018213	Bacterial transcriptional activator domain; Region: BTAD; smart01043
298654018214	AMP-binding enzyme; Region: AMP-binding; pfam00501
298654018215	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654018216	acyl-activating enzyme (AAE) consensus motif; other site
298654018217	AMP binding site [chemical binding]; other site
298654018218	active site
298654018219	CoA binding site [chemical binding]; other site
298654018220	Domain of unknown function (DUF1931); Region: DUF1931; pfam09123
298654018221	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
298654018222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654018223	Walker A motif; other site
298654018224	ATP binding site [chemical binding]; other site
298654018225	Walker B motif; other site
298654018226	arginine finger; other site
298654018227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654018228	Walker A motif; other site
298654018229	ATP binding site [chemical binding]; other site
298654018230	Walker B motif; other site
298654018231	arginine finger; other site
298654018232	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
298654018233	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
298654018234	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
298654018235	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298654018236	HSP70 interaction site [polypeptide binding]; other site
298654018237	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
298654018238	substrate binding site [polypeptide binding]; other site
298654018239	dimer interface [polypeptide binding]; other site
298654018240	GrpE; Region: GrpE; pfam01025
298654018241	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
298654018242	dimer interface [polypeptide binding]; other site
298654018243	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
298654018244	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
298654018245	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
298654018246	nucleotide binding site [chemical binding]; other site
298654018247	NEF interaction site [polypeptide binding]; other site
298654018248	SBD interface [polypeptide binding]; other site
298654018249	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
298654018250	putative hydrophobic ligand binding site [chemical binding]; other site
298654018251	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
298654018252	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654018253	NAD binding site [chemical binding]; other site
298654018254	catalytic Zn binding site [ion binding]; other site
298654018255	structural Zn binding site [ion binding]; other site
298654018256	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
298654018257	propionate/acetate kinase; Provisional; Region: PRK12379
298654018258	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298654018259	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
298654018260	NAD(P) binding site [chemical binding]; other site
298654018261	catalytic residues [active]
298654018262	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
298654018263	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298654018264	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298654018265	ligand binding site [chemical binding]; other site
298654018266	flexible hinge region; other site
298654018267	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
298654018268	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654018269	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298654018270	NlpC/P60 family; Region: NLPC_P60; pfam00877
298654018271	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298654018272	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654018273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654018274	metal binding site [ion binding]; metal-binding site
298654018275	active site
298654018276	I-site; other site
298654018277	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654018278	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
298654018279	apolar tunnel; other site
298654018280	heme binding site [chemical binding]; other site
298654018281	dimerization interface [polypeptide binding]; other site
298654018282	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
298654018283	AAA domain; Region: AAA_30; pfam13604
298654018284	Family description; Region: UvrD_C_2; pfam13538
298654018285	Transposase; Region: HTH_Tnp_1; cl17663
298654018286	putative transposase OrfB; Reviewed; Region: PHA02517
298654018287	HTH-like domain; Region: HTH_21; pfam13276
298654018288	Integrase core domain; Region: rve; pfam00665
298654018289	Integrase core domain; Region: rve_3; pfam13683
298654018290	Protein kinase domain; Region: Pkinase; pfam00069
298654018291	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654018292	active site
298654018293	ATP binding site [chemical binding]; other site
298654018294	substrate binding site [chemical binding]; other site
298654018295	activation loop (A-loop); other site
298654018296	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654018297	Transcriptional regulator PadR-like family; Region: PadR; cl17335
298654018298	TIR domain; Region: TIR_2; pfam13676
298654018299	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654018300	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298654018301	structural tetrad; other site
298654018302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654018303	S-adenosylmethionine binding site [chemical binding]; other site
298654018304	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
298654018305	putative hydrophobic ligand binding site [chemical binding]; other site
298654018306	CsbD-like; Region: CsbD; pfam05532
298654018307	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
298654018308	putative active site [active]
298654018309	transaldolase; Provisional; Region: PRK03903
298654018310	catalytic residue [active]
298654018311	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
298654018312	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
298654018313	TPP-binding site [chemical binding]; other site
298654018314	dimer interface [polypeptide binding]; other site
298654018315	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
298654018316	PYR/PP interface [polypeptide binding]; other site
298654018317	dimer interface [polypeptide binding]; other site
298654018318	TPP binding site [chemical binding]; other site
298654018319	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654018320	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654018321	Hemerythrin-like domain; Region: Hr-like; cd12108
298654018322	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
298654018323	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654018324	NAD binding site [chemical binding]; other site
298654018325	catalytic Zn binding site [ion binding]; other site
298654018326	structural Zn binding site [ion binding]; other site
298654018327	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
298654018328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654018329	S-adenosylmethionine binding site [chemical binding]; other site
298654018330	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
298654018331	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
298654018332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654018333	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654018334	NAD(P) binding site [chemical binding]; other site
298654018335	active site
298654018336	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
298654018337	intracellular protease, PfpI family; Region: PfpI; TIGR01382
298654018338	proposed catalytic triad [active]
298654018339	conserved cys residue [active]
298654018340	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
298654018341	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
298654018342	heme binding pocket [chemical binding]; other site
298654018343	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
298654018344	domain interactions; other site
298654018345	Protein of unknown function DUF72; Region: DUF72; pfam01904
298654018346	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654018347	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
298654018348	Protein of unknown function DUF72; Region: DUF72; pfam01904
298654018349	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298654018350	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
298654018351	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
298654018352	putative dimer interface [polypeptide binding]; other site
298654018353	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298654018354	DNA binding residues [nucleotide binding]
298654018355	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298654018356	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
298654018357	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
298654018358	Gas vesicle protein K; Region: GvpK; pfam05121
298654018359	gas vesicle synthesis-like protein; Reviewed; Region: PRK09368
298654018360	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
298654018361	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
298654018362	putative hydrophobic ligand binding site [chemical binding]; other site
298654018363	Hemerythrin-like domain; Region: Hr-like; cd12108
298654018364	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
298654018365	Protein of unknown function DUF72; Region: DUF72; pfam01904
298654018366	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
298654018367	putative hydrophobic ligand binding site [chemical binding]; other site
298654018368	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654018369	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654018370	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654018371	TAP-like protein; Region: Abhydrolase_4; pfam08386
298654018372	Predicted membrane protein [Function unknown]; Region: COG4270
298654018373	Protein of unknown function (DUF1360); Region: DUF1360; pfam07098
298654018374	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
298654018375	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
298654018376	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
298654018377	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
298654018378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
298654018379	active site
298654018380	dimerization interface [polypeptide binding]; other site
298654018381	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654018382	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
298654018383	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
298654018384	[2Fe-2S] cluster binding site [ion binding]; other site
298654018385	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
298654018386	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298654018387	active site
298654018388	motif I; other site
298654018389	motif II; other site
298654018390	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298654018391	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654018392	active site
298654018393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654018394	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654018395	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654018396	thiamine pyrophosphate protein; Provisional; Region: PRK08273
298654018397	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
298654018398	PYR/PP interface [polypeptide binding]; other site
298654018399	dimer interface [polypeptide binding]; other site
298654018400	tetramer interface [polypeptide binding]; other site
298654018401	TPP binding site [chemical binding]; other site
298654018402	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298654018403	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
298654018404	TPP-binding site [chemical binding]; other site
298654018405	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
298654018406	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298654018407	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298654018408	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
298654018409	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
298654018410	metal binding site [ion binding]; metal-binding site
298654018411	substrate binding pocket [chemical binding]; other site
298654018412	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
298654018413	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
298654018414	short chain dehydrogenase; Provisional; Region: PRK07109
298654018415	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
298654018416	putative NAD(P) binding site [chemical binding]; other site
298654018417	active site
298654018418	Protein of unknown function DUF72; Region: DUF72; pfam01904
298654018419	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298654018420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018421	active site
298654018422	phosphorylation site [posttranslational modification]
298654018423	intermolecular recognition site; other site
298654018424	dimerization interface [polypeptide binding]; other site
298654018425	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654018426	Winged helix-turn helix; Region: HTH_29; pfam13551
298654018427	Helix-turn-helix domain; Region: HTH_28; pfam13518
298654018428	Homeodomain-like domain; Region: HTH_32; pfam13565
298654018429	Integrase core domain; Region: rve; pfam00665
298654018430	Integrase core domain; Region: rve_3; pfam13683
298654018431	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654018432	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654018433	[2Fe-2S] cluster binding site [ion binding]; other site
298654018434	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
298654018435	hydrophobic ligand binding site; other site
298654018436	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654018437	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654018438	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018439	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018440	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654018441	classical (c) SDRs; Region: SDR_c; cd05233
298654018442	NAD(P) binding site [chemical binding]; other site
298654018443	active site
298654018444	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
298654018445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654018446	dimerization interface [polypeptide binding]; other site
298654018447	putative DNA binding site [nucleotide binding]; other site
298654018448	putative Zn2+ binding site [ion binding]; other site
298654018449	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
298654018450	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654018451	putative metal binding site [ion binding]; other site
298654018452	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
298654018453	amphipathic channel; other site
298654018454	Asn-Pro-Ala signature motifs; other site
298654018455	Low molecular weight phosphatase family; Region: LMWPc; cd00115
298654018456	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
298654018457	active site
298654018458	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
298654018459	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298654018460	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
298654018461	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654018462	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654018463	putative ligand binding site [chemical binding]; other site
298654018464	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654018465	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298654018466	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654018467	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654018468	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018469	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018474	SnoaL-like domain; Region: SnoaL_4; pfam13577
298654018475	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
298654018476	classical (c) SDRs; Region: SDR_c; cd05233
298654018477	NAD(P) binding site [chemical binding]; other site
298654018478	active site
298654018479	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654018480	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
298654018481	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654018482	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654018483	Cytochrome P450; Region: p450; cl12078
298654018484	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298654018485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298654018486	metal binding site [ion binding]; metal-binding site
298654018487	active site
298654018488	I-site; other site
298654018489	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
298654018490	putative active site [active]
298654018491	putative substrate binding site [chemical binding]; other site
298654018492	ATP binding site [chemical binding]; other site
298654018493	Phosphotransferase enzyme family; Region: APH; pfam01636
298654018494	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298654018495	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424
298654018496	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
298654018497	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
298654018498	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654018499	Walker A/P-loop; other site
298654018500	ATP binding site [chemical binding]; other site
298654018501	Q-loop/lid; other site
298654018502	ABC transporter signature motif; other site
298654018503	Walker B; other site
298654018504	D-loop; other site
298654018505	H-loop/switch region; other site
298654018506	Histidine kinase; Region: HisKA_3; pfam07730
298654018507	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
298654018508	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654018509	Mg2+ binding site [ion binding]; other site
298654018510	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654018511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018512	active site
298654018513	phosphorylation site [posttranslational modification]
298654018514	intermolecular recognition site; other site
298654018515	dimerization interface [polypeptide binding]; other site
298654018516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654018517	DNA binding residues [nucleotide binding]
298654018518	dimerization interface [polypeptide binding]; other site
298654018519	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298654018520	NlpC/P60 family; Region: NLPC_P60; pfam00877
298654018521	Domain of unknown function (DUF305); Region: DUF305; pfam03713
298654018522	Penicillinase repressor; Region: Pencillinase_R; pfam03965
298654018523	Peptidase family M48; Region: Peptidase_M48; cl12018
298654018524	AAA ATPase domain; Region: AAA_16; pfam13191
298654018525	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654018526	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654018527	DNA binding residues [nucleotide binding]
298654018528	dimerization interface [polypeptide binding]; other site
298654018529	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
298654018530	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
298654018531	Na binding site [ion binding]; other site
298654018532	GAF domain; Region: GAF; pfam01590
298654018533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654018534	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
298654018535	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654018536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018537	active site
298654018538	phosphorylation site [posttranslational modification]
298654018539	intermolecular recognition site; other site
298654018540	dimerization interface [polypeptide binding]; other site
298654018541	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654018542	DNA binding residues [nucleotide binding]
298654018543	AAA ATPase domain; Region: AAA_16; pfam13191
298654018544	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654018545	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654018546	DNA binding residues [nucleotide binding]
298654018547	dimerization interface [polypeptide binding]; other site
298654018548	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
298654018549	gating phenylalanine in ion channel; other site
298654018550	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654018551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654018552	putative substrate translocation pore; other site
298654018553	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
298654018554	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654018555	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654018556	AAA ATPase domain; Region: AAA_16; pfam13191
298654018557	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654018558	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654018559	DNA binding residues [nucleotide binding]
298654018560	dimerization interface [polypeptide binding]; other site
298654018561	AAA ATPase domain; Region: AAA_16; pfam13191
298654018562	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298654018563	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
298654018564	putative NAD(P) binding site [chemical binding]; other site
298654018565	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
298654018566	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654018567	Epoxide hydrolase N terminus; Region: EHN; pfam06441
298654018568	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298654018569	MarR family; Region: MarR_2; pfam12802
298654018570	Putative zinc-finger; Region: zf-HC2; pfam13490
298654018571	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
298654018572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654018573	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654018574	DNA binding residues [nucleotide binding]
298654018575	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
298654018576	iron-sulfur cluster [ion binding]; other site
298654018577	[2Fe-2S] cluster binding site [ion binding]; other site
298654018578	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
298654018579	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
298654018580	active site
298654018581	FMN binding site [chemical binding]; other site
298654018582	substrate binding site [chemical binding]; other site
298654018583	3Fe-4S cluster binding site [ion binding]; other site
298654018584	short chain dehydrogenase; Validated; Region: PRK08264
298654018585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654018586	NAD(P) binding site [chemical binding]; other site
298654018587	active site
298654018588	Cupin; Region: Cupin_6; pfam12852
298654018589	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298654018590	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298654018591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654018592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654018593	putative substrate translocation pore; other site
298654018594	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
298654018595	Moco binding site; other site
298654018596	metal coordination site [ion binding]; other site
298654018597	dimerization interface [polypeptide binding]; other site
298654018598	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654018599	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
298654018600	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
298654018601	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
298654018602	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
298654018603	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
298654018604	active site
298654018605	putative catalytic site [active]
298654018606	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
298654018607	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298654018608	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298654018609	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
298654018610	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654018611	DNA-binding site [nucleotide binding]; DNA binding site
298654018612	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654018613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654018614	homodimer interface [polypeptide binding]; other site
298654018615	catalytic residue [active]
298654018616	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
298654018617	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654018618	WD40 repeats; Region: WD40; smart00320
298654018619	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654018620	structural tetrad; other site
298654018621	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654018622	structural tetrad; other site
298654018623	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654018624	WD domain, G-beta repeat; Region: WD40; pfam00400
298654018625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654018626	TPR motif; other site
298654018627	binding surface
298654018628	TPR repeat; Region: TPR_11; pfam13414
298654018629	SIR2-like domain; Region: SIR2_2; pfam13289
298654018630	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018631	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018632	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018634	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018636	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654018637	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018638	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654018639	HEXXH motif domain; Region: mod_HExxH; TIGR04267
298654018640	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
298654018641	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654018642	FeS/SAM binding site; other site
298654018643	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
298654018644	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
298654018645	putative di-iron ligands [ion binding]; other site
298654018646	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
298654018647	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
298654018648	FAD binding pocket [chemical binding]; other site
298654018649	FAD binding motif [chemical binding]; other site
298654018650	phosphate binding motif [ion binding]; other site
298654018651	beta-alpha-beta structure motif; other site
298654018652	NAD binding pocket [chemical binding]; other site
298654018653	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654018654	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
298654018655	catalytic loop [active]
298654018656	iron binding site [ion binding]; other site
298654018657	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298654018658	DNA-binding site [nucleotide binding]; DNA binding site
298654018659	RNA-binding motif; other site
298654018660	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
298654018661	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298654018662	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654018663	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298654018664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654018665	DNA binding residues [nucleotide binding]
298654018666	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
298654018667	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
298654018668	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298654018669	active site
298654018670	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
298654018671	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298654018672	DNA-binding site [nucleotide binding]; DNA binding site
298654018673	RNA-binding motif; other site
298654018674	nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103
298654018675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654018676	FeS/SAM binding site; other site
298654018677	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
298654018678	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
298654018679	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
298654018680	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
298654018681	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
298654018682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298654018683	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654018684	non-specific DNA binding site [nucleotide binding]; other site
298654018685	salt bridge; other site
298654018686	sequence-specific DNA binding site [nucleotide binding]; other site
298654018687	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298654018688	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
298654018689	classical (c) SDRs; Region: SDR_c; cd05233
298654018690	NAD(P) binding site [chemical binding]; other site
298654018691	active site
298654018692	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
298654018693	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298654018694	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
298654018695	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
298654018696	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
298654018697	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
298654018698	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
298654018699	FMN-binding pocket [chemical binding]; other site
298654018700	flavin binding motif; other site
298654018701	phosphate binding motif [ion binding]; other site
298654018702	beta-alpha-beta structure motif; other site
298654018703	NAD binding pocket [chemical binding]; other site
298654018704	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298654018705	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
298654018706	catalytic loop [active]
298654018707	iron binding site [ion binding]; other site
298654018708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654018709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654018710	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298654018711	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
298654018712	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
298654018713	[2Fe-2S] cluster binding site [ion binding]; other site
298654018714	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
298654018715	alpha subunit interface [polypeptide binding]; other site
298654018716	active site
298654018717	substrate binding site [chemical binding]; other site
298654018718	Fe binding site [ion binding]; other site
298654018719	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654018720	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654018721	NAD(P) binding site [chemical binding]; other site
298654018722	active site
298654018723	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
298654018724	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
298654018725	putative DNA binding site [nucleotide binding]; other site
298654018726	catalytic residue [active]
298654018727	putative H2TH interface [polypeptide binding]; other site
298654018728	putative catalytic residues [active]
298654018729	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
298654018730	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
298654018731	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
298654018732	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
298654018733	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654018734	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
298654018735	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
298654018736	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
298654018737	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654018738	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654018739	active site
298654018740	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
298654018741	putative active site [active]
298654018742	putative catalytic site [active]
298654018743	hypothetical protein; Provisional; Region: PRK06815
298654018744	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
298654018745	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654018746	catalytic residue [active]
298654018747	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654018748	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298654018749	putative DNA binding site [nucleotide binding]; other site
298654018750	dimerization interface [polypeptide binding]; other site
298654018751	putative Zn2+ binding site [ion binding]; other site
298654018752	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
298654018753	putative dimerization interface [polypeptide binding]; other site
298654018754	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654018755	non-specific DNA binding site [nucleotide binding]; other site
298654018756	salt bridge; other site
298654018757	sequence-specific DNA binding site [nucleotide binding]; other site
298654018758	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
298654018759	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
298654018760	Ligand binding site; other site
298654018761	Ligand binding site; other site
298654018762	Ligand binding site; other site
298654018763	Putative Catalytic site; other site
298654018764	DXD motif; other site
298654018765	Predicted membrane protein [Function unknown]; Region: COG2246
298654018766	GtrA-like protein; Region: GtrA; pfam04138
298654018767	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298654018768	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654018769	dimer interface [polypeptide binding]; other site
298654018770	phosphorylation site [posttranslational modification]
298654018771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654018772	ATP binding site [chemical binding]; other site
298654018773	Mg2+ binding site [ion binding]; other site
298654018774	G-X-G motif; other site
298654018775	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654018776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018777	active site
298654018778	phosphorylation site [posttranslational modification]
298654018779	intermolecular recognition site; other site
298654018780	dimerization interface [polypeptide binding]; other site
298654018781	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654018782	DNA binding site [nucleotide binding]
298654018783	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
298654018784	Anti-sigma-K factor rskA; Region: RskA; pfam10099
298654018785	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
298654018786	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654018787	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654018788	DNA binding residues [nucleotide binding]
298654018789	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654018790	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
298654018791	Helix-turn-helix domain; Region: HTH_18; pfam12833
298654018792	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
298654018793	putative dimer interface [polypeptide binding]; other site
298654018794	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654018795	Part of AAA domain; Region: AAA_19; pfam13245
298654018796	Family description; Region: UvrD_C_2; pfam13538
298654018797	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654018798	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298654018799	Peptidase family M50; Region: Peptidase_M50; pfam02163
298654018800	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
298654018801	hydrophobic ligand binding site; other site
298654018802	Methyltransferase domain; Region: Methyltransf_31; pfam13847
298654018803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654018804	S-adenosylmethionine binding site [chemical binding]; other site
298654018805	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654018806	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654018807	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298654018808	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298654018809	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
298654018810	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298654018811	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298654018812	catalytic residues [active]
298654018813	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654018814	nudix motif; other site
298654018815	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654018816	Amidohydrolase; Region: Amidohydro_4; pfam13147
298654018817	active site
298654018818	Putative sensor; Region: Sensor; pfam13796
298654018819	Histidine kinase; Region: HisKA_3; pfam07730
298654018820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654018821	ATP binding site [chemical binding]; other site
298654018822	Mg2+ binding site [ion binding]; other site
298654018823	G-X-G motif; other site
298654018824	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
298654018825	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
298654018826	oligomer interface [polypeptide binding]; other site
298654018827	metal binding site [ion binding]; metal-binding site
298654018828	metal binding site [ion binding]; metal-binding site
298654018829	putative Cl binding site [ion binding]; other site
298654018830	aspartate ring; other site
298654018831	basic sphincter; other site
298654018832	hydrophobic gate; other site
298654018833	periplasmic entrance; other site
298654018834	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
298654018835	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
298654018836	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
298654018837	Ligand Binding Site [chemical binding]; other site
298654018838	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298654018839	dimer interface [polypeptide binding]; other site
298654018840	phosphorylation site [posttranslational modification]
298654018841	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654018842	ATP binding site [chemical binding]; other site
298654018843	Mg2+ binding site [ion binding]; other site
298654018844	G-X-G motif; other site
298654018845	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
298654018846	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018847	active site
298654018848	phosphorylation site [posttranslational modification]
298654018849	intermolecular recognition site; other site
298654018850	dimerization interface [polypeptide binding]; other site
298654018851	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654018852	DNA binding site [nucleotide binding]
298654018853	PBP superfamily domain; Region: PBP_like_2; cl17296
298654018854	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
298654018855	catalytic residue [active]
298654018856	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654018857	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298654018858	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298654018859	ATP binding site [chemical binding]; other site
298654018860	putative Mg++ binding site [ion binding]; other site
298654018861	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654018862	nucleotide binding region [chemical binding]; other site
298654018863	ATP-binding site [chemical binding]; other site
298654018864	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
298654018865	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298654018866	putative active site [active]
298654018867	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
298654018868	active site
298654018869	DNA-sulfur modification-associated; Region: DndB; cl17621
298654018870	ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592
298654018871	Z1 domain; Region: Z1; pfam10593
298654018872	Domain of unknown function (DUF4420); Region: DUF4420; pfam14390
298654018873	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
298654018874	ATP binding site [chemical binding]; other site
298654018875	Mg2+ binding site [ion binding]; other site
298654018876	G-X-G motif; other site
298654018877	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
298654018878	putative active site [active]
298654018879	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
298654018880	active site
298654018881	PAS domain; Region: PAS_9; pfam13426
298654018882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298654018883	putative active site [active]
298654018884	heme pocket [chemical binding]; other site
298654018885	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654018886	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654018887	non-specific DNA binding site [nucleotide binding]; other site
298654018888	salt bridge; other site
298654018889	sequence-specific DNA binding site [nucleotide binding]; other site
298654018890	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654018891	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298654018892	DNA-binding site [nucleotide binding]; DNA binding site
298654018893	RNA-binding motif; other site
298654018894	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
298654018895	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
298654018896	dimer interface [polypeptide binding]; other site
298654018897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654018898	catalytic residue [active]
298654018899	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
298654018900	cystathionine gamma-synthase; Provisional; Region: PRK07811
298654018901	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
298654018902	homodimer interface [polypeptide binding]; other site
298654018903	substrate-cofactor binding pocket; other site
298654018904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654018905	catalytic residue [active]
298654018906	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298654018907	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298654018908	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
298654018909	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654018910	active site
298654018911	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298654018912	catalytic core [active]
298654018913	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
298654018914	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
298654018915	dimer interface [polypeptide binding]; other site
298654018916	acyl-activating enzyme (AAE) consensus motif; other site
298654018917	putative active site [active]
298654018918	AMP binding site [chemical binding]; other site
298654018919	putative CoA binding site [chemical binding]; other site
298654018920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018921	Response regulator receiver domain; Region: Response_reg; pfam00072
298654018922	active site
298654018923	phosphorylation site [posttranslational modification]
298654018924	intermolecular recognition site; other site
298654018925	dimerization interface [polypeptide binding]; other site
298654018926	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654018927	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654018928	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298654018929	dimerization interface [polypeptide binding]; other site
298654018930	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654018931	dihydroorotase; Provisional; Region: PRK09237
298654018932	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654018933	active site
298654018934	4Fe-4S binding domain; Region: Fer4; pfam00037
298654018935	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
298654018936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654018937	ATP binding site [chemical binding]; other site
298654018938	G-X-G motif; other site
298654018939	Response regulator receiver domain; Region: Response_reg; pfam00072
298654018940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018941	active site
298654018942	phosphorylation site [posttranslational modification]
298654018943	intermolecular recognition site; other site
298654018944	dimerization interface [polypeptide binding]; other site
298654018945	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
298654018946	cyclase homology domain; Region: CHD; cd07302
298654018947	nucleotidyl binding site; other site
298654018948	metal binding site [ion binding]; metal-binding site
298654018949	dimer interface [polypeptide binding]; other site
298654018950	short chain dehydrogenase; Provisional; Region: PRK06123
298654018951	classical (c) SDRs; Region: SDR_c; cd05233
298654018952	NAD(P) binding site [chemical binding]; other site
298654018953	active site
298654018954	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
298654018955	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654018956	Uncharacterized conserved protein [Function unknown]; Region: COG3391
298654018957	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
298654018958	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298654018959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654018960	NAD(P) binding site [chemical binding]; other site
298654018961	active site
298654018962	probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854
298654018963	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654018964	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654018965	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654018966	active site
298654018967	ATP binding site [chemical binding]; other site
298654018968	substrate binding site [chemical binding]; other site
298654018969	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654018970	substrate binding site [chemical binding]; other site
298654018971	activation loop (A-loop); other site
298654018972	activation loop (A-loop); other site
298654018973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654018974	S-adenosylmethionine binding site [chemical binding]; other site
298654018975	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298654018976	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298654018977	ligand binding site [chemical binding]; other site
298654018978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654018979	ATP binding site [chemical binding]; other site
298654018980	G-X-G motif; other site
298654018981	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654018982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654018983	active site
298654018984	phosphorylation site [posttranslational modification]
298654018985	intermolecular recognition site; other site
298654018986	dimerization interface [polypeptide binding]; other site
298654018987	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654018988	DNA binding residues [nucleotide binding]
298654018989	Predicted peptidase [General function prediction only]; Region: COG4099
298654018990	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654018991	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
298654018992	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
298654018993	classical (c) SDRs; Region: SDR_c; cd05233
298654018994	NAD(P) binding site [chemical binding]; other site
298654018995	active site
298654018996	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
298654018997	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654018998	acyl-activating enzyme (AAE) consensus motif; other site
298654018999	AMP binding site [chemical binding]; other site
298654019000	active site
298654019001	CoA binding site [chemical binding]; other site
298654019002	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
298654019003	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298654019004	catalytic residue [active]
298654019005	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
298654019006	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
298654019007	FAD binding domain; Region: FAD_binding_4; pfam01565
298654019008	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
298654019009	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
298654019010	putative deacylase active site [active]
298654019011	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654019012	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654019013	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
298654019014	putative dimerization interface [polypeptide binding]; other site
298654019015	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
298654019016	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
298654019017	Walker A/P-loop; other site
298654019018	ATP binding site [chemical binding]; other site
298654019019	Q-loop/lid; other site
298654019020	ABC transporter signature motif; other site
298654019021	Walker B; other site
298654019022	D-loop; other site
298654019023	H-loop/switch region; other site
298654019024	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654019025	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
298654019026	Walker A/P-loop; other site
298654019027	ATP binding site [chemical binding]; other site
298654019028	Q-loop/lid; other site
298654019029	ABC transporter signature motif; other site
298654019030	Walker B; other site
298654019031	D-loop; other site
298654019032	H-loop/switch region; other site
298654019033	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
298654019034	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
298654019035	TM-ABC transporter signature motif; other site
298654019036	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654019037	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
298654019038	TM-ABC transporter signature motif; other site
298654019039	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
298654019040	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
298654019041	dimerization interface [polypeptide binding]; other site
298654019042	ligand binding site [chemical binding]; other site
298654019043	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
298654019044	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
298654019045	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298654019046	HSP70 interaction site [polypeptide binding]; other site
298654019047	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
298654019048	CoA-transferase family III; Region: CoA_transf_3; pfam02515
298654019049	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
298654019050	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298654019051	MarR family; Region: MarR; pfam01047
298654019052	Predicted membrane protein [Function unknown]; Region: COG2259
298654019053	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654019054	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
298654019055	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
298654019056	Ligand binding site; other site
298654019057	Ligand binding site; other site
298654019058	Ligand binding site; other site
298654019059	Putative Catalytic site; other site
298654019060	DXD motif; other site
298654019061	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
298654019062	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
298654019063	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
298654019064	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
298654019065	XdhC Rossmann domain; Region: XdhC_C; pfam13478
298654019066	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
298654019067	metal-binding site
298654019068	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298654019069	nucleotide binding site [chemical binding]; other site
298654019070	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298654019071	SBD interface [polypeptide binding]; other site
298654019072	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298654019073	E3 interaction surface; other site
298654019074	lipoyl attachment site [posttranslational modification]; other site
298654019075	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654019076	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654019077	structural tetrad; other site
298654019078	pyruvate carboxylase; Reviewed; Region: PRK12999
298654019079	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298654019080	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298654019081	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
298654019082	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
298654019083	active site
298654019084	catalytic residues [active]
298654019085	metal binding site [ion binding]; metal-binding site
298654019086	homodimer binding site [polypeptide binding]; other site
298654019087	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298654019088	carboxyltransferase (CT) interaction site; other site
298654019089	biotinylation site [posttranslational modification]; other site
298654019090	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654019091	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654019092	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654019093	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654019094	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654019095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654019096	Walker A motif; other site
298654019097	ATP binding site [chemical binding]; other site
298654019098	Walker B motif; other site
298654019099	arginine finger; other site
298654019100	Protein kinase domain; Region: Pkinase; pfam00069
298654019101	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654019102	active site
298654019103	ATP binding site [chemical binding]; other site
298654019104	substrate binding site [chemical binding]; other site
298654019105	activation loop (A-loop); other site
298654019106	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654019107	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654019108	active site
298654019109	ATP binding site [chemical binding]; other site
298654019110	substrate binding site [chemical binding]; other site
298654019111	activation loop (A-loop); other site
298654019112	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298654019113	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298654019114	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298654019115	Protein of unknown function DUF58; Region: DUF58; pfam01882
298654019116	MoxR-like ATPases [General function prediction only]; Region: COG0714
298654019117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654019118	ATP binding site [chemical binding]; other site
298654019119	Walker A motif; other site
298654019120	Walker B motif; other site
298654019121	arginine finger; other site
298654019122	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654019123	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654019124	active site
298654019125	ATP binding site [chemical binding]; other site
298654019126	substrate binding site [chemical binding]; other site
298654019127	activation loop (A-loop); other site
298654019128	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
298654019129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019130	Response regulator receiver domain; Region: Response_reg; pfam00072
298654019131	active site
298654019132	phosphorylation site [posttranslational modification]
298654019133	intermolecular recognition site; other site
298654019134	dimerization interface [polypeptide binding]; other site
298654019135	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019137	active site
298654019138	phosphorylation site [posttranslational modification]
298654019139	intermolecular recognition site; other site
298654019140	dimerization interface [polypeptide binding]; other site
298654019141	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019142	DNA binding residues [nucleotide binding]
298654019143	dimerization interface [polypeptide binding]; other site
298654019144	Protein of unknown function (DUF664); Region: DUF664; pfam04978
298654019145	DinB superfamily; Region: DinB_2; pfam12867
298654019146	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
298654019147	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
298654019148	GAF domain; Region: GAF; cl17456
298654019149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654019150	Histidine kinase; Region: HisKA_3; pfam07730
298654019151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654019152	ATP binding site [chemical binding]; other site
298654019153	Mg2+ binding site [ion binding]; other site
298654019154	G-X-G motif; other site
298654019155	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654019156	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654019157	Walker A/P-loop; other site
298654019158	ATP binding site [chemical binding]; other site
298654019159	Q-loop/lid; other site
298654019160	ABC transporter signature motif; other site
298654019161	Walker B; other site
298654019162	D-loop; other site
298654019163	H-loop/switch region; other site
298654019164	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654019165	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298654019166	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
298654019167	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
298654019168	homodimer interface [polypeptide binding]; other site
298654019169	putative substrate binding pocket [chemical binding]; other site
298654019170	diiron center [ion binding]; other site
298654019171	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
298654019172	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298654019173	thymidylate kinase; Provisional; Region: PRK13975; cl17243
298654019174	Histidine kinase; Region: HisKA_3; pfam07730
298654019175	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019177	active site
298654019178	phosphorylation site [posttranslational modification]
298654019179	intermolecular recognition site; other site
298654019180	dimerization interface [polypeptide binding]; other site
298654019181	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019182	DNA binding residues [nucleotide binding]
298654019183	dimerization interface [polypeptide binding]; other site
298654019184	Domain of unknown function (DUF385); Region: DUF385; cl04387
298654019185	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654019186	Walker A/P-loop; other site
298654019187	ATP binding site [chemical binding]; other site
298654019188	ABC transporter; Region: ABC_tran; pfam00005
298654019189	Q-loop/lid; other site
298654019190	ABC transporter signature motif; other site
298654019191	Walker B; other site
298654019192	D-loop; other site
298654019193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654019194	H-loop/switch region; other site
298654019195	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
298654019196	Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174
298654019197	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
298654019198	Moco binding site; other site
298654019199	metal coordination site [ion binding]; other site
298654019200	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
298654019201	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654019202	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654019203	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654019204	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654019205	Walker A/P-loop; other site
298654019206	ATP binding site [chemical binding]; other site
298654019207	Q-loop/lid; other site
298654019208	ABC transporter signature motif; other site
298654019209	Walker B; other site
298654019210	D-loop; other site
298654019211	H-loop/switch region; other site
298654019212	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298654019213	Interferon-induced transmembrane protein; Region: CD225; pfam04505
298654019214	Interferon-induced transmembrane protein; Region: CD225; pfam04505
298654019215	TIGR03085 family protein; Region: TIGR03085
298654019216	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
298654019217	nudix motif; other site
298654019218	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
298654019219	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298654019220	NlpC/P60 family; Region: NLPC_P60; pfam00877
298654019221	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
298654019222	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
298654019223	catalytic triad [active]
298654019224	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
298654019225	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
298654019226	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
298654019227	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
298654019228	nucleoside/Zn binding site; other site
298654019229	dimer interface [polypeptide binding]; other site
298654019230	catalytic motif [active]
298654019231	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
298654019232	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654019233	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
298654019234	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
298654019235	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
298654019236	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298654019237	NAD binding site [chemical binding]; other site
298654019238	substrate binding site [chemical binding]; other site
298654019239	putative active site [active]
298654019240	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298654019241	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654019242	catalytic residue [active]
298654019243	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
298654019244	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
298654019245	cofactor binding site; other site
298654019246	DNA binding site [nucleotide binding]
298654019247	substrate interaction site [chemical binding]; other site
298654019248	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
298654019249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654019250	non-specific DNA binding site [nucleotide binding]; other site
298654019251	salt bridge; other site
298654019252	sequence-specific DNA binding site [nucleotide binding]; other site
298654019253	Transcription factor WhiB; Region: Whib; pfam02467
298654019254	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298654019255	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
298654019256	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
298654019257	dimer interface [polypeptide binding]; other site
298654019258	ssDNA binding site [nucleotide binding]; other site
298654019259	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298654019260	DNA binding domain, excisionase family; Region: excise; TIGR01764
298654019261	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
298654019262	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654019263	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654019264	active site
298654019265	DNA binding site [nucleotide binding]
298654019266	Int/Topo IB signature motif; other site
298654019267	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
298654019268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654019269	Walker A motif; other site
298654019270	ATP binding site [chemical binding]; other site
298654019271	Walker B motif; other site
298654019272	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
298654019273	hypothetical protein; Validated; Region: PRK00153
298654019274	recombination protein RecR; Reviewed; Region: recR; PRK00076
298654019275	Helix-hairpin-helix motif; Region: HHH; pfam00633
298654019276	helix-hairpin-helix signature motif; other site
298654019277	RecR protein; Region: RecR; pfam02132
298654019278	active site
298654019279	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
298654019280	putative active site [active]
298654019281	putative metal-binding site [ion binding]; other site
298654019282	tetramer interface [polypeptide binding]; other site
298654019283	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654019284	NAD(P) binding site [chemical binding]; other site
298654019285	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
298654019286	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
298654019287	putative metal binding site [ion binding]; other site
298654019288	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654019289	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298654019290	Walker A/P-loop; other site
298654019291	ATP binding site [chemical binding]; other site
298654019292	Q-loop/lid; other site
298654019293	ABC transporter signature motif; other site
298654019294	Walker B; other site
298654019295	D-loop; other site
298654019296	H-loop/switch region; other site
298654019297	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298654019298	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298654019299	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654019300	Histidine kinase; Region: HisKA_3; pfam07730
298654019301	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019303	active site
298654019304	phosphorylation site [posttranslational modification]
298654019305	intermolecular recognition site; other site
298654019306	dimerization interface [polypeptide binding]; other site
298654019307	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019308	DNA binding residues [nucleotide binding]
298654019309	dimerization interface [polypeptide binding]; other site
298654019310	aspartate kinase; Reviewed; Region: PRK06635
298654019311	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
298654019312	putative nucleotide binding site [chemical binding]; other site
298654019313	putative catalytic residues [active]
298654019314	putative Mg ion binding site [ion binding]; other site
298654019315	putative aspartate binding site [chemical binding]; other site
298654019316	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
298654019317	putative allosteric regulatory site; other site
298654019318	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
298654019319	putative allosteric regulatory residue; other site
298654019320	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
298654019321	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298654019322	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298654019323	DNA-binding site [nucleotide binding]; DNA binding site
298654019324	RNA-binding motif; other site
298654019325	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
298654019326	putative active site; other site
298654019327	putative metal binding residues [ion binding]; other site
298654019328	signature motif; other site
298654019329	putative triphosphate binding site [ion binding]; other site
298654019330	CHAD domain; Region: CHAD; pfam05235
298654019331	CAAX protease self-immunity; Region: Abi; pfam02517
298654019332	Penicillinase repressor; Region: Pencillinase_R; cl17580
298654019333	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
298654019334	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
298654019335	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
298654019336	catalytic triad [active]
298654019337	MarR family; Region: MarR; pfam01047
298654019338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654019339	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298654019340	putative substrate translocation pore; other site
298654019341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654019342	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
298654019343	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
298654019344	DNA binding site [nucleotide binding]
298654019345	active site
298654019346	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
298654019347	minor groove reading motif; other site
298654019348	helix-hairpin-helix signature motif; other site
298654019349	Nuclease-related domain; Region: NERD; pfam08378
298654019350	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298654019351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298654019352	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
298654019353	dimerization interface [polypeptide binding]; other site
298654019354	substrate binding pocket [chemical binding]; other site
298654019355	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654019356	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654019357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654019358	non-specific DNA binding site [nucleotide binding]; other site
298654019359	sequence-specific DNA binding site [nucleotide binding]; other site
298654019360	salt bridge; other site
298654019361	Domain of unknown function (DUF397); Region: DUF397; pfam04149
298654019362	SPFH domain / Band 7 family; Region: Band_7; pfam01145
298654019363	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
298654019364	nudix motif; other site
298654019365	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
298654019366	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
298654019367	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654019368	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298654019369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654019370	NAD(P) binding site [chemical binding]; other site
298654019371	active site
298654019372	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
298654019373	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
298654019374	inhibitor-cofactor binding pocket; inhibition site
298654019375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654019376	catalytic residue [active]
298654019377	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654019378	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
298654019379	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298654019380	Radical SAM superfamily; Region: Radical_SAM; pfam04055
298654019381	FeS/SAM binding site; other site
298654019382	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298654019383	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
298654019384	dimerization interface [polypeptide binding]; other site
298654019385	putative ATP binding site [chemical binding]; other site
298654019386	Predicted amidohydrolase [General function prediction only]; Region: COG0388
298654019387	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
298654019388	active site
298654019389	catalytic triad [active]
298654019390	dimer interface [polypeptide binding]; other site
298654019391	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
298654019392	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298654019393	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
298654019394	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298654019395	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654019396	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298654019397	catalytic site [active]
298654019398	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654019399	Domain of unknown function (DUF427); Region: DUF427; pfam04248
298654019400	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298654019401	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
298654019402	active site
298654019403	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298654019404	catalytic triad [active]
298654019405	dimer interface [polypeptide binding]; other site
298654019406	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298654019407	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298654019408	DNA binding site [nucleotide binding]
298654019409	domain linker motif; other site
298654019410	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
298654019411	putative dimerization interface [polypeptide binding]; other site
298654019412	putative ligand binding site [chemical binding]; other site
298654019413	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
298654019414	beta-galactosidase; Region: BGL; TIGR03356
298654019415	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298654019416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654019417	dimer interface [polypeptide binding]; other site
298654019418	conserved gate region; other site
298654019419	putative PBP binding loops; other site
298654019420	ABC-ATPase subunit interface; other site
298654019421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654019422	dimer interface [polypeptide binding]; other site
298654019423	conserved gate region; other site
298654019424	putative PBP binding loops; other site
298654019425	ABC-ATPase subunit interface; other site
298654019426	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
298654019427	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298654019428	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
298654019429	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
298654019430	Walker A/P-loop; other site
298654019431	ATP binding site [chemical binding]; other site
298654019432	Q-loop/lid; other site
298654019433	ABC transporter signature motif; other site
298654019434	Walker B; other site
298654019435	D-loop; other site
298654019436	H-loop/switch region; other site
298654019437	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
298654019438	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
298654019439	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
298654019440	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
298654019441	hydrophobic ligand binding site; other site
298654019442	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654019443	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654019444	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654019445	catalytic residue [active]
298654019446	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654019447	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654019448	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298654019449	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
298654019450	Frankia-40 domain; Region: Frankia_40_dom; TIGR03917
298654019451	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
298654019452	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298654019453	DNA-binding site [nucleotide binding]; DNA binding site
298654019454	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
298654019455	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
298654019456	active site
298654019457	catalytic triad [active]
298654019458	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
298654019459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654019460	Walker A motif; other site
298654019461	ATP binding site [chemical binding]; other site
298654019462	Walker B motif; other site
298654019463	arginine finger; other site
298654019464	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
298654019465	TrwC relaxase; Region: TrwC; pfam08751
298654019466	AAA domain; Region: AAA_30; pfam13604
298654019467	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654019468	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654019469	Walker A/P-loop; other site
298654019470	ATP binding site [chemical binding]; other site
298654019471	Q-loop/lid; other site
298654019472	ABC transporter signature motif; other site
298654019473	Walker B; other site
298654019474	D-loop; other site
298654019475	H-loop/switch region; other site
298654019476	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
298654019477	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
298654019478	active site
298654019479	zinc binding site [ion binding]; other site
298654019480	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
298654019481	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
298654019482	SpaB C-terminal domain; Region: SpaB_C; pfam14028
298654019483	FxLD family lantipeptide; Region: LD_lanti_pre; TIGR04363
298654019484	methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364
298654019485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654019486	S-adenosylmethionine binding site [chemical binding]; other site
298654019487	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654019488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654019489	non-specific DNA binding site [nucleotide binding]; other site
298654019490	salt bridge; other site
298654019491	sequence-specific DNA binding site [nucleotide binding]; other site
298654019492	Flavoprotein; Region: Flavoprotein; pfam02441
298654019493	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
298654019494	mismatch recognition site; other site
298654019495	additional DNA contacts [nucleotide binding]; other site
298654019496	active site
298654019497	zinc binding site [ion binding]; other site
298654019498	DNA intercalation site [nucleotide binding]; other site
298654019499	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
298654019500	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
298654019501	cofactor binding site; other site
298654019502	DNA binding site [nucleotide binding]
298654019503	substrate interaction site [chemical binding]; other site
298654019504	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
298654019505	Nuclease-related domain; Region: NERD; pfam08378
298654019506	AAA domain; Region: AAA_22; pfam13401
298654019507	Family description; Region: UvrD_C_2; pfam13538
298654019508	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298654019509	ATP-binding site [chemical binding]; other site
298654019510	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
298654019511	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298654019512	salt bridge; other site
298654019513	non-specific DNA binding site [nucleotide binding]; other site
298654019514	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298654019515	sequence-specific DNA binding site [nucleotide binding]; other site
298654019516	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
298654019517	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
298654019518	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654019519	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298654019520	DNA binding residues [nucleotide binding]
298654019521	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298654019522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654019523	Walker A/P-loop; other site
298654019524	ATP binding site [chemical binding]; other site
298654019525	Q-loop/lid; other site
298654019526	ABC transporter signature motif; other site
298654019527	Walker B; other site
298654019528	D-loop; other site
298654019529	H-loop/switch region; other site
298654019530	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
298654019531	Epoxide hydrolase N terminus; Region: EHN; pfam06441
298654019532	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654019533	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
298654019534	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341
298654019535	putative ligand binding site [chemical binding]; other site
298654019536	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
298654019537	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654019538	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654019539	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654019540	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298654019541	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298654019542	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654019543	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298654019544	active site
298654019545	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
298654019546	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654019547	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654019548	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654019549	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654019550	S-adenosylmethionine binding site [chemical binding]; other site
298654019551	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
298654019552	coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024
298654019553	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654019554	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298654019555	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019556	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019557	DNA binding residues [nucleotide binding]
298654019558	dimerization interface [polypeptide binding]; other site
298654019559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654019560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654019561	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
298654019562	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654019563	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
298654019564	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298654019565	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
298654019566	acyl-activating enzyme (AAE) consensus motif; other site
298654019567	acyl-activating enzyme (AAE) consensus motif; other site
298654019568	putative AMP binding site [chemical binding]; other site
298654019569	putative active site [active]
298654019570	putative CoA binding site [chemical binding]; other site
298654019571	Amidohydrolase; Region: Amidohydro_2; pfam04909
298654019572	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298654019573	active site
298654019574	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654019575	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
298654019576	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
298654019577	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298654019578	nudix motif; other site
298654019579	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654019580	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654019581	active site
298654019582	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298654019583	DinB superfamily; Region: DinB_2; pfam12867
298654019584	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298654019585	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
298654019586	dimer interface [polypeptide binding]; other site
298654019587	decamer (pentamer of dimers) interface [polypeptide binding]; other site
298654019588	catalytic triad [active]
298654019589	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
298654019590	Phosphotransferase enzyme family; Region: APH; pfam01636
298654019591	Ecdysteroid kinase; Region: EcKinase; cl17738
298654019592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019594	active site
298654019595	phosphorylation site [posttranslational modification]
298654019596	intermolecular recognition site; other site
298654019597	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019598	DNA binding residues [nucleotide binding]
298654019599	dimerization interface [polypeptide binding]; other site
298654019600	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
298654019601	Histidine kinase; Region: HisKA_3; pfam07730
298654019602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298654019603	ATP binding site [chemical binding]; other site
298654019604	Mg2+ binding site [ion binding]; other site
298654019605	G-X-G motif; other site
298654019606	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
298654019607	iron-sulfur cluster [ion binding]; other site
298654019608	[2Fe-2S] cluster binding site [ion binding]; other site
298654019609	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298654019610	phosphopeptide binding site; other site
298654019611	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
298654019612	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
298654019613	iron-sulfur cluster [ion binding]; other site
298654019614	[2Fe-2S] cluster binding site [ion binding]; other site
298654019615	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
298654019616	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298654019617	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298654019618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298654019619	putative substrate translocation pore; other site
298654019620	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298654019621	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
298654019622	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
298654019623	nudix motif; other site
298654019624	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
298654019625	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
298654019626	amidase; Provisional; Region: PRK06061
298654019627	Amidase; Region: Amidase; pfam01425
298654019628	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
298654019629	Carboxylesterase family; Region: COesterase; pfam00135
298654019630	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298654019631	substrate binding pocket [chemical binding]; other site
298654019632	catalytic triad [active]
298654019633	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
298654019634	DNA binding residues [nucleotide binding]
298654019635	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
298654019636	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
298654019637	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298654019638	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
298654019639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298654019640	dimer interface [polypeptide binding]; other site
298654019641	conserved gate region; other site
298654019642	putative PBP binding loops; other site
298654019643	ABC-ATPase subunit interface; other site
298654019644	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
298654019645	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654019646	Walker A/P-loop; other site
298654019647	ATP binding site [chemical binding]; other site
298654019648	Q-loop/lid; other site
298654019649	ABC transporter signature motif; other site
298654019650	Walker B; other site
298654019651	D-loop; other site
298654019652	H-loop/switch region; other site
298654019653	TOBE domain; Region: TOBE; cl01440
298654019654	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298654019655	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298654019656	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654019657	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298654019658	NAD(P) binding site [chemical binding]; other site
298654019659	active site
298654019660	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298654019661	Cytochrome P450; Region: p450; cl12078
298654019662	TIR domain; Region: TIR_2; pfam13676
298654019663	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654019664	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654019665	structural tetrad; other site
298654019666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298654019667	TPR motif; other site
298654019668	binding surface
298654019669	Tetratricopeptide repeat; Region: TPR_16; pfam13432
298654019670	SIR2-like domain; Region: SIR2_2; pfam13289
298654019671	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654019672	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654019673	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654019674	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298654019675	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654019676	Tetratricopeptide repeat; Region: TPR_10; pfam13374
298654019677	HEXXH motif domain; Region: mod_HExxH; TIGR04267
298654019678	radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269
298654019679	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
298654019680	Papillomavirus helicase; Region: PPV_E1_C; pfam00519
298654019681	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
298654019682	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
298654019683	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
298654019684	xylose isomerase; Provisional; Region: PRK12677
298654019685	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
298654019686	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654019687	nucleotide binding site [chemical binding]; other site
298654019688	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298654019689	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298654019690	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
298654019691	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
298654019692	putative ligand binding site [chemical binding]; other site
298654019693	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
298654019694	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298654019695	Walker A/P-loop; other site
298654019696	ATP binding site [chemical binding]; other site
298654019697	Q-loop/lid; other site
298654019698	ABC transporter signature motif; other site
298654019699	Walker B; other site
298654019700	D-loop; other site
298654019701	H-loop/switch region; other site
298654019702	Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172
298654019703	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298654019704	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298654019705	TM-ABC transporter signature motif; other site
298654019706	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
298654019707	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
298654019708	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
298654019709	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
298654019710	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
298654019711	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
298654019712	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
298654019713	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298654019714	Phage protein D [General function prediction only]; Region: COG3500
298654019715	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
298654019716	PAAR motif; Region: PAAR_motif; cl15808
298654019717	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
298654019718	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
298654019719	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
298654019720	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
298654019721	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
298654019722	phage tail protein domain; Region: tail_TIGR02242
298654019723	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019725	active site
298654019726	phosphorylation site [posttranslational modification]
298654019727	intermolecular recognition site; other site
298654019728	dimerization interface [polypeptide binding]; other site
298654019729	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019730	DNA binding residues [nucleotide binding]
298654019731	Bacterial transcriptional activator domain; Region: BTAD; smart01043
298654019732	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
298654019733	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298654019734	Walker A motif; other site
298654019735	ATP binding site [chemical binding]; other site
298654019736	Walker B motif; other site
298654019737	arginine finger; other site
298654019738	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
298654019739	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
298654019740	classical (c) SDRs; Region: SDR_c; cd05233
298654019741	NAD(P) binding site [chemical binding]; other site
298654019742	active site
298654019743	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298654019744	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
298654019745	NAD(P) binding site [chemical binding]; other site
298654019746	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298654019747	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
298654019748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298654019749	Coenzyme A binding pocket [chemical binding]; other site
298654019750	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298654019751	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298654019752	Walker A/P-loop; other site
298654019753	ATP binding site [chemical binding]; other site
298654019754	Q-loop/lid; other site
298654019755	ABC transporter signature motif; other site
298654019756	Walker B; other site
298654019757	D-loop; other site
298654019758	H-loop/switch region; other site
298654019759	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298654019760	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298654019761	S-adenosylmethionine binding site [chemical binding]; other site
298654019762	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654019763	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654019764	active site
298654019765	ATP binding site [chemical binding]; other site
298654019766	substrate binding site [chemical binding]; other site
298654019767	activation loop (A-loop); other site
298654019768	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
298654019769	Interdomain contacts; other site
298654019770	Cytokine receptor motif; other site
298654019771	GAF domain; Region: GAF; pfam01590
298654019772	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298654019773	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
298654019774	DNA binding residues [nucleotide binding]
298654019775	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
298654019776	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
298654019777	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
298654019778	NAD binding site [chemical binding]; other site
298654019779	Phe binding site; other site
298654019780	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
298654019781	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
298654019782	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
298654019783	dimerization interface [polypeptide binding]; other site
298654019784	putative ATP binding site [chemical binding]; other site
298654019785	amidophosphoribosyltransferase; Provisional; Region: PRK07847
298654019786	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
298654019787	active site
298654019788	tetramer interface [polypeptide binding]; other site
298654019789	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298654019790	active site
298654019791	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
298654019792	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
298654019793	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298654019794	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298654019795	DNA binding site [nucleotide binding]
298654019796	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
298654019797	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
298654019798	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
298654019799	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298654019800	MarR family; Region: MarR; pfam01047
298654019801	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
298654019802	Citrate synthase; Region: Citrate_synt; pfam00285
298654019803	oxalacetate binding site [chemical binding]; other site
298654019804	citrylCoA binding site [chemical binding]; other site
298654019805	coenzyme A binding site [chemical binding]; other site
298654019806	catalytic triad [active]
298654019807	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
298654019808	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298654019809	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
298654019810	citrate synthase 2; Provisional; Region: PRK12350
298654019811	Citrate synthase; Region: Citrate_synt; pfam00285
298654019812	oxalacetate binding site [chemical binding]; other site
298654019813	citrylCoA binding site [chemical binding]; other site
298654019814	coenzyme A binding site [chemical binding]; other site
298654019815	catalytic triad [active]
298654019816	phosphoserine aminotransferase; Provisional; Region: PRK03080
298654019817	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298654019818	catalytic residue [active]
298654019819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
298654019820	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298654019821	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298654019822	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
298654019823	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
298654019824	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
298654019825	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298654019826	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298654019827	protein binding site [polypeptide binding]; other site
298654019828	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
298654019829	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298654019830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298654019831	active site
298654019832	phosphorylation site [posttranslational modification]
298654019833	intermolecular recognition site; other site
298654019834	dimerization interface [polypeptide binding]; other site
298654019835	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298654019836	DNA binding residues [nucleotide binding]
298654019837	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
298654019838	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
298654019839	MOSC domain; Region: MOSC; pfam03473
298654019840	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
298654019841	CopC domain; Region: CopC; pfam04234
298654019842	Copper resistance protein D; Region: CopD; pfam05425
298654019843	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
298654019844	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
298654019845	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
298654019846	intersubunit interface [polypeptide binding]; other site
298654019847	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
298654019848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298654019849	Walker A/P-loop; other site
298654019850	ATP binding site [chemical binding]; other site
298654019851	Q-loop/lid; other site
298654019852	ABC transporter signature motif; other site
298654019853	Walker B; other site
298654019854	D-loop; other site
298654019855	H-loop/switch region; other site
298654019856	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
298654019857	dimer interface [polypeptide binding]; other site
298654019858	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
298654019859	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
298654019860	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
298654019861	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
298654019862	putative DNA binding helix; other site
298654019863	metal binding site 2 [ion binding]; metal-binding site
298654019864	metal binding site 1 [ion binding]; metal-binding site
298654019865	dimer interface [polypeptide binding]; other site
298654019866	structural Zn2+ binding site [ion binding]; other site
298654019867	aminotransferase AlaT; Validated; Region: PRK09265
298654019868	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298654019869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298654019870	homodimer interface [polypeptide binding]; other site
298654019871	catalytic residue [active]
298654019872	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
298654019873	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
298654019874	putative active site [active]
298654019875	putative metal binding site [ion binding]; other site
298654019876	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
298654019877	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
298654019878	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
298654019879	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
298654019880	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
298654019881	TPP-binding site [chemical binding]; other site
298654019882	tetramer interface [polypeptide binding]; other site
298654019883	heterodimer interface [polypeptide binding]; other site
298654019884	phosphorylation loop region [posttranslational modification]
298654019885	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
298654019886	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
298654019887	alpha subunit interface [polypeptide binding]; other site
298654019888	TPP binding site [chemical binding]; other site
298654019889	heterodimer interface [polypeptide binding]; other site
298654019890	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298654019891	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298654019892	E3 interaction surface; other site
298654019893	lipoyl attachment site [posttranslational modification]; other site
298654019894	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
298654019895	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298654019896	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
298654019897	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
298654019898	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298654019899	active site
298654019900	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
298654019901	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
298654019902	Double zinc ribbon; Region: DZR; pfam12773
298654019903	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
298654019904	cyclase homology domain; Region: CHD; cd07302
298654019905	nucleotidyl binding site; other site
298654019906	metal binding site [ion binding]; metal-binding site
298654019907	dimer interface [polypeptide binding]; other site
298654019908	Predicted ATPase [General function prediction only]; Region: COG3899
298654019909	AAA ATPase domain; Region: AAA_16; pfam13191
298654019910	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298654019911	anti sigma factor interaction site; other site
298654019912	regulatory phosphorylation site [posttranslational modification]; other site
298654019913	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
298654019914	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
298654019915	active site
298654019916	dimer interface [polypeptide binding]; other site
298654019917	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
298654019918	dimer interface [polypeptide binding]; other site
298654019919	active site
298654019920	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654019921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654019922	active site
298654019923	ATP binding site [chemical binding]; other site
298654019924	substrate binding site [chemical binding]; other site
298654019925	activation loop (A-loop); other site
298654019926	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654019927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654019928	active site
298654019929	ATP binding site [chemical binding]; other site
298654019930	substrate binding site [chemical binding]; other site
298654019931	activation loop (A-loop); other site
298654019932	NHL repeat; Region: NHL; pfam01436
298654019933	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298654019934	FAD binding domain; Region: FAD_binding_4; pfam01565
298654019935	Berberine and berberine like; Region: BBE; pfam08031
298654019936	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
298654019937	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298654019938	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298654019939	catalytic residue [active]
298654019940	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298654019941	NlpC/P60 family; Region: NLPC_P60; pfam00877
298654019942	Helix-turn-helix domain; Region: HTH_17; cl17695
298654019943	AAA-like domain; Region: AAA_10; pfam12846
298654019944	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
298654019945	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
298654019946	cofactor binding site; other site
298654019947	DNA binding site [nucleotide binding]
298654019948	substrate interaction site [chemical binding]; other site
298654019949	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654019950	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
298654019951	active site
298654019952	Nuclease-related domain; Region: NERD; pfam08378
298654019953	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
298654019954	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
298654019955	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
298654019956	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
298654019957	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
298654019958	putative active site [active]
298654019959	putative dimer interface [polypeptide binding]; other site
298654019960	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
298654019961	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
298654019962	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
298654019963	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298654019964	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298654019965	active site
298654019966	ATP binding site [chemical binding]; other site
298654019967	substrate binding site [chemical binding]; other site
298654019968	activation loop (A-loop); other site
298654019969	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298654019970	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
298654019971	structural tetrad; other site
298654019972	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
298654019973	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298654019974	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298654019975	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
298654019976	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
298654019977	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
298654019978	replicative DNA helicase; Region: DnaB; TIGR00665
298654019979	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
298654019980	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
298654019981	Walker A motif; other site
298654019982	ATP binding site [chemical binding]; other site
298654019983	Walker B motif; other site
298654019984	DNA binding loops [nucleotide binding]
298654019985	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
298654019986	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
298654019987	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
298654019988	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
298654019989	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
298654019990	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
298654019991	dimer interface [polypeptide binding]; other site
298654019992	ssDNA binding site [nucleotide binding]; other site
298654019993	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298654019994	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
298654019995	Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188
298654019996	Predicted integral membrane protein [Function unknown]; Region: COG5650
298654019997	SnoaL-like domain; Region: SnoaL_2; pfam12680
298654019998	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
298654019999	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
298654020000	acyl-activating enzyme (AAE) consensus motif; other site
298654020001	active site
298654020002	Phosphopantetheine attachment site; Region: PP-binding; cl09936
298654020003	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
298654020004	active site
298654020005	oxyanion hole [active]
298654020006	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
298654020007	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298654020008	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
298654020009	Transglycosylase; Region: Transgly; pfam00912
298654020010	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
298654020011	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
298654020012	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
298654020013	Predicted transcriptional regulators [Transcription]; Region: COG1695
298654020014	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298654020015	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
298654020016	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
298654020017	metal ion-dependent adhesion site (MIDAS); other site
298654020018	H+ Antiporter protein; Region: 2A0121; TIGR00900
298654020019	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
298654020020	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
298654020021	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
298654020022	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
298654020023	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
298654020024	active site
298654020025	NTP binding site [chemical binding]; other site
298654020026	metal binding triad [ion binding]; metal-binding site
298654020027	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
298654020028	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298654020029	Zn2+ binding site [ion binding]; other site
298654020030	Mg2+ binding site [ion binding]; other site
298654020031	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
298654020032	active site
298654020033	Ap6A binding site [chemical binding]; other site
298654020034	nudix motif; other site
298654020035	metal binding site [ion binding]; metal-binding site
298654020036	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
298654020037	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298654020038	active site
298654020039	ATP binding site [chemical binding]; other site
298654020040	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
298654020041	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298654020042	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
298654020043	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298654020044	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298654020045	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298654020046	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298654020047	catalytic residues [active]
298654020048	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
298654020049	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654020050	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298654020051	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
298654020052	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
298654020053	active site
298654020054	metal binding site [ion binding]; metal-binding site
298654020055	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
298654020056	ParB-like nuclease domain; Region: ParBc; pfam02195
298654020057	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298654020058	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298654020059	Magnesium ion binding site [ion binding]; other site
298654020060	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
298654020061	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
298654020062	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654020063	Domain of unknown function (DUF222); Region: DUF222; pfam02720
298654020064	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298654020065	active site
298654020066	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
298654020067	G-X-X-G motif; other site
298654020068	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
298654020069	RxxxH motif; other site
298654020070	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
298654020071	Haemolytic domain; Region: Haemolytic; cl00506
298654020072	Ribonuclease P; Region: Ribonuclease_P; pfam00825
298654020073	Ribosomal protein L34; Region: Ribosomal_L34; cl00370