-- dump date 20140619_095251 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 458234000001 SEQ_END SEQ_END NC_009749.1 1890909 1890909 DR NC_009749.1; contig end 1890909..1890909 Francisella tularensis subsp. holarctica FTNF002-00 YP_001427435.2 CDS dnaA NC_009749.1 1 1476 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1476 Francisella tularensis subsp. holarctica FTNF002-00 5524566 YP_001427436.1 CDS dnaN NC_009749.1 1513 2616 D DNA polymerase III subunit beta 1513..2616 Francisella tularensis subsp. holarctica FTNF002-00 5524565 YP_001427437.1 CDS FTA_0002 NC_009749.1 2613 3050 R putative MFS transporter protein complement(2613..3050) Francisella tularensis subsp. holarctica FTNF002-00 5524102 YP_001427438.2 CDS FTA_0004 NC_009749.1 3062 3942 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(3062..3613,3613..3942)) Francisella tularensis subsp. holarctica FTNF002-00 5524103 YP_001427443.1 CDS FTA_0009 NC_009749.1 6630 6833 R hypothetical protein complement(6630..6833) Francisella tularensis subsp. holarctica FTNF002-00 5524381 YP_001427444.2 CDS FTA_0010 NC_009749.1 6907 7830 D S49 family peptidase 6907..7830 Francisella tularensis subsp. holarctica FTNF002-00 5524382 YP_001427445.1 CDS FTA_0011 NC_009749.1 7884 8459 D Omp-H like outer membrane protein 7884..8459 Francisella tularensis subsp. holarctica FTNF002-00 5524383 YP_001427446.1 CDS FTA_0012 NC_009749.1 8595 9017 D rhodanese-like domain-containing protein 8595..9017 Francisella tularensis subsp. holarctica FTNF002-00 5524385 YP_001427447.1 CDS secB1 NC_009749.1 9044 9493 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 9044..9493 Francisella tularensis subsp. holarctica FTNF002-00 5524384 YP_001427448.1 CDS recA NC_009749.1 9515 10594 D catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 9515..10594 Francisella tularensis subsp. holarctica FTNF002-00 5522846 YP_001427449.1 CDS recX NC_009749.1 10581 11033 D regulatory protein RecX 10581..11033 Francisella tularensis subsp. holarctica FTNF002-00 5522847 YP_001427450.1 CDS FTA_0016 NC_009749.1 11206 11682 D single-stranded DNA binding protein 11206..11682 Francisella tularensis subsp. holarctica FTNF002-00 5522848 YP_001427451.1 CDS ackA NC_009749.1 11788 12942 D acetate kinase 11788..12942 Francisella tularensis subsp. holarctica FTNF002-00 5522849 YP_001427452.2 CDS FTA_0018 NC_009749.1 12952 15048 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 12952..15048 Francisella tularensis subsp. holarctica FTNF002-00 5522850 YP_001427455.2 CDS FTA_0020 NC_009749.1 15960 16840 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(15960..16511,16511..16840)) Francisella tularensis subsp. holarctica FTNF002-00 5522853 YP_001427458.1 CDS aspS NC_009749.1 17335 19107 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(17335..19107) Francisella tularensis subsp. holarctica FTNF002-00 5522856 YP_001427459.1 CDS FTA_0025 NC_009749.1 19281 20462 R major facilitator transporter complement(19281..20462) Francisella tularensis subsp. holarctica FTNF002-00 5522858 YP_001427462.2 CDS FTA_0028 NC_009749.1 21104 21984 D programmed ribosomal frameshift; transposase ISFtu1 join(21104..21433,21433..21984) Francisella tularensis subsp. holarctica FTNF002-00 5523318 YP_001715622.1 CDS FTA_2141 NC_009749.1 22210 22380 R hypothetical protein complement(22210..22380) Francisella tularensis subsp. holarctica FTNF002-00 5983823 YP_001427465.1 CDS FTA_0031 NC_009749.1 22931 24154 R amino acid transporter complement(22931..24154) Francisella tularensis subsp. holarctica FTNF002-00 5523322 YP_001427466.1 CDS FTA_0032 NC_009749.1 24481 24714 R hypothetical protein complement(24481..24714) Francisella tularensis subsp. holarctica FTNF002-00 5524332 YP_001427469.1 CDS pyrB NC_009749.1 26097 27017 R aspartate carbamoyltransferase complement(26097..27017) Francisella tularensis subsp. holarctica FTNF002-00 5523325 YP_001427470.1 CDS carB NC_009749.1 27159 30443 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(27159..30443) Francisella tularensis subsp. holarctica FTNF002-00 5523326 YP_001427471.1 CDS carA NC_009749.1 30448 31614 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(30448..31614) Francisella tularensis subsp. holarctica FTNF002-00 5523327 YP_001427472.1 CDS FTA_0038 NC_009749.1 32031 33086 D acid phosphatase 32031..33086 Francisella tularensis subsp. holarctica FTNF002-00 5523329 YP_001427473.1 CDS FTA_0039 NC_009749.1 33210 33890 R catalyzes the S-adenosylmethionine-dependent transmethylation of thiopurine compounds; may be involved in selenium cycling by forming dimethylselenide and/or dimethyldiselenide; thiopurine S-methyltransferase complement(33210..33890) Francisella tularensis subsp. holarctica FTNF002-00 5523328 YP_001427474.1 CDS pyrC NC_009749.1 34022 35368 D Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; dihydroorotase 34022..35368 Francisella tularensis subsp. holarctica FTNF002-00 5523216 YP_001427475.1 CDS FTA_0041 NC_009749.1 35396 36436 R hypothetical protein complement(35396..36436) Francisella tularensis subsp. holarctica FTNF002-00 5523217 YP_001427477.1 CDS FTA_0043 NC_009749.1 37640 38191 D hypothetical protein 37640..38191 Francisella tularensis subsp. holarctica FTNF002-00 5523219 YP_001427478.1 CDS FTA_0044 NC_009749.1 38307 39359 R hypothetical protein complement(38307..39359) Francisella tularensis subsp. holarctica FTNF002-00 5523220 YP_001427479.1 CDS FTA_0045 NC_009749.1 39346 40311 R HlyD family secretion protein complement(39346..40311) Francisella tularensis subsp. holarctica FTNF002-00 5523221 YP_001427480.1 CDS FTA_0046 NC_009749.1 40400 40807 R lipoprotein complement(40400..40807) Francisella tularensis subsp. holarctica FTNF002-00 5523222 YP_001427481.1 CDS FTA_0047 NC_009749.1 40933 41802 D LysR family transcriptional regulator 40933..41802 Francisella tularensis subsp. holarctica FTNF002-00 5523223 YP_001427482.1 CDS FTA_0048 NC_009749.1 41803 42174 R N-terminal truncation; SOUL heme-binding protein complement(41803..42174) Francisella tularensis subsp. holarctica FTNF002-00 5523224 YP_001427483.1 CDS FTA_0050 NC_009749.1 42338 42475 D hypothetical protein 42338..42475 Francisella tularensis subsp. holarctica FTNF002-00 5523225 YP_001427484.1 CDS FTA_0049 NC_009749.1 42464 43117 R transposase ISFTu2 complement(42464..43117) Francisella tularensis subsp. holarctica FTNF002-00 5523228 YP_001427485.1 CDS FTA_0051 NC_009749.1 43429 43977 D chorismate mutase 43429..43977 Francisella tularensis subsp. holarctica FTNF002-00 5523226 YP_001427486.1 CDS FTA_0052 NC_009749.1 44032 47265 R transglutaminase-like superfamily protein complement(44032..47265) Francisella tularensis subsp. holarctica FTNF002-00 5523227 YP_001427487.2 CDS pyrF NC_009749.1 47685 48317 D orotidine 5'-phosphate decarboxylase 47685..48317 Francisella tularensis subsp. holarctica FTNF002-00 5524364 YP_001427488.1 CDS FTA_0054 NC_009749.1 48307 49065 D dihydroorotate dehydrogenase 48307..49065 Francisella tularensis subsp. holarctica FTNF002-00 5524365 YP_001427491.1 CDS dtd NC_009749.1 50528 50965 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(50528..50965) Francisella tularensis subsp. holarctica FTNF002-00 5524368 YP_001427494.2 CDS FTA_0060 NC_009749.1 52459 53883 R glycosyl hydrolase family protein complement(52459..53883) Francisella tularensis subsp. holarctica FTNF002-00 5524371 YP_001427495.2 CDS FTA_0061 NC_009749.1 54142 55022 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(54142..54693,54693..55022)) Francisella tularensis subsp. holarctica FTNF002-00 5524372 YP_001427497.2 CDS FTA_0063 NC_009749.1 55046 55597 R hypothetical protein complement(55046..55597) Francisella tularensis subsp. holarctica FTNF002-00 5524374 YP_001427498.1 CDS FTA_0064 NC_009749.1 55868 56533 R nitroreductase family protein complement(55868..56533) Francisella tularensis subsp. holarctica FTNF002-00 5524376 YP_001427499.1 CDS FTA_0066 NC_009749.1 56936 57628 D contains DUF1275; hypothetical protein 56936..57628 Francisella tularensis subsp. holarctica FTNF002-00 5524375 YP_001427500.1 CDS FTA_0065 NC_009749.1 57625 58830 R tryptophan/tyrosine permease family protein complement(57625..58830) Francisella tularensis subsp. holarctica FTNF002-00 5523462 YP_001427501.1 CDS gidB NC_009749.1 58930 59547 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 58930..59547 Francisella tularensis subsp. holarctica FTNF002-00 5523464 YP_001427502.1 CDS FTA_0069 NC_009749.1 59544 60212 D hypothetical protein 59544..60212 Francisella tularensis subsp. holarctica FTNF002-00 5523463 YP_001427503.1 CDS FTA_0068 NC_009749.1 60205 61089 R hypothetical protein complement(60205..61089) Francisella tularensis subsp. holarctica FTNF002-00 5523465 YP_001427504.1 CDS FTA_0070 NC_009749.1 61291 61986 R LysR family transcriptional regulator complement(61291..61986) Francisella tularensis subsp. holarctica FTNF002-00 5523467 YP_001427505.1 CDS FTA_0071 NC_009749.1 62145 62276 D hypothetical protein 62145..62276 Francisella tularensis subsp. holarctica FTNF002-00 5523466 YP_001427506.1 CDS FTA_0072 NC_009749.1 62289 63425 D major facilitator transporter 62289..63425 Francisella tularensis subsp. holarctica FTNF002-00 5523468 YP_001427510.1 CDS gmhA NC_009749.1 65949 66545 D phosphoheptose isomerase 65949..66545 Francisella tularensis subsp. holarctica FTNF002-00 5523472 YP_001427511.1 CDS FTA_0077 NC_009749.1 66553 66909 D Smp A/Oml family membrane lipoprotein 66553..66909 Francisella tularensis subsp. holarctica FTNF002-00 5523474 YP_001427512.1 CDS rpsT NC_009749.1 66983 67255 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(66983..67255) Francisella tularensis subsp. holarctica FTNF002-00 5523473 YP_001427513.1 CDS lepA NC_009749.1 67525 69309 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 67525..69309 Francisella tularensis subsp. holarctica FTNF002-00 5524580 YP_001427514.1 CDS mnmA NC_009749.1 69323 70402 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 69323..70402 Francisella tularensis subsp. holarctica FTNF002-00 5524581 YP_001427515.1 CDS FTA_0081 NC_009749.1 70422 71414 R lipoprotein complement(70422..71414) Francisella tularensis subsp. holarctica FTNF002-00 5524582 YP_001427516.1 CDS def1 NC_009749.1 71496 72020 R peptide deformylase complement(71496..72020) Francisella tularensis subsp. holarctica FTNF002-00 5524583 YP_001427517.1 CDS ribH NC_009749.1 72017 72460 R 6,7-dimethyl-8-ribityllumazine synthase complement(72017..72460) Francisella tularensis subsp. holarctica FTNF002-00 5524584 YP_001427518.1 CDS ribAB NC_009749.1 72470 73681 R bifunctional enzyme with 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II activities; bifunctional riboflavin biosynthesis protein complement(72470..73681) Francisella tularensis subsp. holarctica FTNF002-00 5524585 YP_001427519.1 CDS ribE NC_009749.1 73674 74279 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(73674..74279) Francisella tularensis subsp. holarctica FTNF002-00 5524586 YP_001427520.1 CDS ribD NC_009749.1 74272 75339 R riboflavin biosynthesis protein complement(74272..75339) Francisella tularensis subsp. holarctica FTNF002-00 5524587 YP_001427522.2 CDS FTA_0088 NC_009749.1 76510 77339 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(76510..77010,77010..77339)) Francisella tularensis subsp. holarctica FTNF002-00 5524333 YP_001427524.1 CDS FTA_0090 NC_009749.1 77583 78233 R major facilitator transporter complement(77583..78233) Francisella tularensis subsp. holarctica FTNF002-00 5524591 YP_001427525.1 CDS FTA_0091 NC_009749.1 78312 78827 R B-type cytochrome subunit complement(78312..78827) Francisella tularensis subsp. holarctica FTNF002-00 5524592 YP_001427528.1 CDS nhaA NC_009749.1 79877 81028 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 79877..81028 Francisella tularensis subsp. holarctica FTNF002-00 5524388 YP_001427529.1 CDS FTA_0095 NC_009749.1 81093 81812 D hypothetical protein 81093..81812 Francisella tularensis subsp. holarctica FTNF002-00 5524389 YP_001427530.2 CDS FTA_0096 NC_009749.1 81818 82558 R acetyltransferase complement(81818..82558) Francisella tularensis subsp. holarctica FTNF002-00 5524390 YP_001427531.2 CDS FTA_0097 NC_009749.1 82572 83324 R acetyltransferase complement(82572..83324) Francisella tularensis subsp. holarctica FTNF002-00 5524391 YP_001427532.2 CDS FTA_0098 NC_009749.1 83487 83810 R 4Fe-4S ferredoxin complement(83487..83810) Francisella tularensis subsp. holarctica FTNF002-00 5524392 YP_001427533.1 CDS FTA_0099 NC_009749.1 84042 84683 D hypothetical protein 84042..84683 Francisella tularensis subsp. holarctica FTNF002-00 5524393 YP_001427535.1 CDS purT NC_009749.1 85416 86576 R non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 complement(85416..86576) Francisella tularensis subsp. holarctica FTNF002-00 5524395 YP_001427536.1 CDS FTA_0102 NC_009749.1 86630 88822 R putative chitinase complement(86630..88822) Francisella tularensis subsp. holarctica FTNF002-00 5524396 YP_001427537.1 CDS FTA_0103 NC_009749.1 89073 91652 R AAA ATPase complement(89073..91652) Francisella tularensis subsp. holarctica FTNF002-00 5524397 YP_001427539.2 CDS FTA_0105 NC_009749.1 92598 92951 D hypothetical protein 92598..92951 Francisella tularensis subsp. holarctica FTNF002-00 5524406 YP_001427540.1 CDS trpA NC_009749.1 93006 93815 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(93006..93815) Francisella tularensis subsp. holarctica FTNF002-00 5524407 YP_001427541.1 CDS trpB NC_009749.1 93815 95005 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(93815..95005) Francisella tularensis subsp. holarctica FTNF002-00 5524408 YP_001427542.2 CDS FTA_0108 NC_009749.1 95092 96597 R M32 family metallocarboxypeptidase complement(95092..96597) Francisella tularensis subsp. holarctica FTNF002-00 5524409 YP_001427543.2 CDS FTA_0109 NC_009749.1 96533 97927 R Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein complement(96533..97927) Francisella tularensis subsp. holarctica FTNF002-00 5524410 YP_001427545.1 CDS FTA_0111 NC_009749.1 98422 98832 R hypothetical protein complement(98422..98832) Francisella tularensis subsp. holarctica FTNF002-00 5524412 YP_001427546.1 CDS FTA_0112 NC_009749.1 98853 99245 R lipoprotein complement(98853..99245) Francisella tularensis subsp. holarctica FTNF002-00 5524413 YP_001427548.2 CDS FTA_0114 NC_009749.1 100047 100927 D programmed ribosomal frameshift; transposase ISFTu1 join(100047..100376,100376..100927) Francisella tularensis subsp. holarctica FTNF002-00 5524415 YP_001427550.1 CDS FTA_0116 NC_009749.1 100928 101800 R major facilitator transporter complement(100928..101800) Francisella tularensis subsp. holarctica FTNF002-00 5524417 YP_001427553.1 CDS iglA1 NC_009749.1 102588 103142 D Several genes in Francisella necessary for replication in macrophages and for virulence including iglA, iglC, and iglD and pathogenicity determinant protein genes pdpD and pdpA, are regulated by MglA. PMID:17000729; intracellular growth locus subunit A 102588..103142 Francisella tularensis subsp. holarctica FTNF002-00 5522819 YP_001427554.1 CDS iglB1 NC_009749.1 103156 104676 D intracellular growth locus subunit B 103156..104676 Francisella tularensis subsp. holarctica FTNF002-00 5522820 YP_001427555.1 CDS iglC1 NC_009749.1 104687 105322 D intracellular growth locus subunit C 104687..105322 Francisella tularensis subsp. holarctica FTNF002-00 5522821 YP_001427556.1 CDS iglD1 NC_009749.1 105343 106539 D intracellular growth locus subunit D 105343..106539 Francisella tularensis subsp. holarctica FTNF002-00 5522822 YP_001427557.1 CDS FTA_0123 NC_009749.1 106546 107121 R hypothetical protein complement(106546..107121) Francisella tularensis subsp. holarctica FTNF002-00 5522823 YP_001427558.1 CDS pdpC1 NC_009749.1 107139 111125 R Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity determinant protein PdpC complement(107139..111125) Francisella tularensis subsp. holarctica FTNF002-00 5522824 YP_001427559.1 CDS FTA_0125 NC_009749.1 111165 111938 R conserved in Francisella spp.; hypothetical protein complement(111165..111938) Francisella tularensis subsp. holarctica FTNF002-00 5522825 YP_001427560.1 CDS FTA_0126 NC_009749.1 111904 113055 R hypothetical protein complement(111904..113055) Francisella tularensis subsp. holarctica FTNF002-00 5522826 YP_001427561.1 CDS FTA_0127 NC_009749.1 113077 113700 R hypothetical protein complement(113077..113700) Francisella tularensis subsp. holarctica FTNF002-00 5522827 YP_001427562.1 CDS FTA_0128 NC_009749.1 113713 115143 R hypothetical protein complement(113713..115143) Francisella tularensis subsp. holarctica FTNF002-00 5522828 YP_001427563.2 CDS FTA_0129 NC_009749.1 115156 115677 R hypothetical protein complement(115156..115677) Francisella tularensis subsp. holarctica FTNF002-00 5522829 YP_001427565.1 CDS FTA_0131 NC_009749.1 117414 117908 R hypothetical protein complement(117414..117908) Francisella tularensis subsp. holarctica FTNF002-00 5523817 YP_001427566.1 CDS FTA_0132 NC_009749.1 117921 118298 R lipoprotein complement(117921..118298) Francisella tularensis subsp. holarctica FTNF002-00 5523818 YP_001427567.1 CDS pdpB1 NC_009749.1 118288 121569 R Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpB complement(118288..121569) Francisella tularensis subsp. holarctica FTNF002-00 5523819 YP_001427568.1 CDS pdpA1 NC_009749.1 121574 124036 R Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpA complement(121574..124036) Francisella tularensis subsp. holarctica FTNF002-00 5523820 YP_001427571.2 CDS FTA_0138 NC_009749.1 130380 131260 D programmed ribosomal frameshift; transposase ISFTu1 join(130380..130709,130709..131260) Francisella tularensis subsp. holarctica FTNF002-00 5523823 YP_001427575.1 CDS ilvE NC_009749.1 132640 133527 R branched-chain amino acid aminotransferase complement(132640..133527) Francisella tularensis subsp. holarctica FTNF002-00 5523827 YP_001427576.1 CDS ppdK NC_009749.1 133928 136576 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(133928..136576) Francisella tularensis subsp. holarctica FTNF002-00 5523828 YP_001427577.1 CDS feoB NC_009749.1 137388 139631 R ferrous iron transport protein B complement(137388..139631) Francisella tularensis subsp. holarctica FTNF002-00 5523829 YP_001427578.2 CDS FTA_0145 NC_009749.1 139700 140200 R hypothetical protein complement(139700..140200) Francisella tularensis subsp. holarctica FTNF002-00 5524593 YP_001427579.2 CDS FTA_0146 NC_009749.1 140160 141040 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(140160..140711,140711..141040)) Francisella tularensis subsp. holarctica FTNF002-00 5524594 YP_001427581.1 CDS FTA_0148 NC_009749.1 141513 142145 R N-terminal truncation compared to Schu4 and FTW; hypothetical protein complement(141513..142145) Francisella tularensis subsp. holarctica FTNF002-00 5524596 YP_001427582.1 CDS FTA_0149 NC_009749.1 142796 143764 R hypothetical protein complement(142796..143764) Francisella tularensis subsp. holarctica FTNF002-00 5524597 YP_001427583.1 CDS FTA_0150 NC_009749.1 143953 145803 D ribonuclease II (RNB-like) family protein 143953..145803 Francisella tularensis subsp. holarctica FTNF002-00 5524598 YP_001427584.2 CDS FTA_0151 NC_009749.1 146140 146808 D carboxylesterase/phospholipase family protein 146140..146808 Francisella tularensis subsp. holarctica FTNF002-00 5524599 YP_001427585.1 CDS hemC NC_009749.1 146805 147707 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 146805..147707 Francisella tularensis subsp. holarctica FTNF002-00 5524600 YP_001427586.1 CDS crcB NC_009749.1 147708 148043 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 147708..148043 Francisella tularensis subsp. holarctica FTNF002-00 5524601 YP_001427587.1 CDS FTA_0154 NC_009749.1 148096 148503 D lipoprotein 148096..148503 Francisella tularensis subsp. holarctica FTNF002-00 5524602 YP_001427588.1 CDS FTA_0155 NC_009749.1 148643 148804 D putative lipoprotein 148643..148804 Francisella tularensis subsp. holarctica FTNF002-00 5524603 YP_001427589.1 CDS FTA_0157 NC_009749.1 148856 149233 D hypothetical protein 148856..149233 Francisella tularensis subsp. holarctica FTNF002-00 5524604 YP_001427590.1 CDS FTA_0156 NC_009749.1 149230 149403 R hypothetical protein complement(149230..149403) Francisella tularensis subsp. holarctica FTNF002-00 5524605 YP_001427591.2 CDS FTA_0158 NC_009749.1 149532 151331 D ABC transporter membrane protein 149532..151331 Francisella tularensis subsp. holarctica FTNF002-00 5523476 YP_001427592.1 CDS FTA_0159 NC_009749.1 151350 152666 D ABC transporter ATP-binding protein 151350..152666 Francisella tularensis subsp. holarctica FTNF002-00 5523475 YP_001427593.1 CDS FTA_0160 NC_009749.1 152753 154291 D hypothetical protein 152753..154291 Francisella tularensis subsp. holarctica FTNF002-00 5523477 YP_001427594.1 CDS FTA_0161 NC_009749.1 154397 156271 D monovalent cation:proton antiporter-2 (CPA2) family protein 154397..156271 Francisella tularensis subsp. holarctica FTNF002-00 5523478 YP_001427595.1 CDS FTA_0162 NC_009749.1 156256 156795 D carbonic anhydrase/acyltransferase family protein 156256..156795 Francisella tularensis subsp. holarctica FTNF002-00 5523479 YP_001427596.1 CDS lolB NC_009749.1 156758 157390 D outer membrane lipoprotein LolB 156758..157390 Francisella tularensis subsp. holarctica FTNF002-00 5523480 YP_001427597.1 CDS ipk NC_009749.1 157378 158205 D An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 157378..158205 Francisella tularensis subsp. holarctica FTNF002-00 5523481 YP_001427598.2 CDS FTA_0165 NC_009749.1 158394 158714 D hypothetical protein 158394..158714 Francisella tularensis subsp. holarctica FTNF002-00 5523483 YP_001427599.2 CDS FTA_0166 NC_009749.1 158738 159618 D programmed ribosomal frameshift; transposase ISFTu1 join(158738..159067,159067..159618) Francisella tularensis subsp. holarctica FTNF002-00 5524399 YP_001427601.1 CDS FTA_0168 NC_009749.1 159674 159859 D hypothetical protein 159674..159859 Francisella tularensis subsp. holarctica FTNF002-00 5523485 YP_001427602.1 CDS FTA_0169 NC_009749.1 159866 160213 R putative cytochrome b561 complement(159866..160213) Francisella tularensis subsp. holarctica FTNF002-00 5523486 YP_001427603.1 CDS FTA_0170 NC_009749.1 160460 161455 R phosphate transporter family protein complement(160460..161455) Francisella tularensis subsp. holarctica FTNF002-00 5523487 YP_001427604.1 CDS FTA_0171 NC_009749.1 161473 162129 R hypothetical protein complement(161473..162129) Francisella tularensis subsp. holarctica FTNF002-00 5523101 YP_001427605.1 CDS FTA_0172 NC_009749.1 162436 163911 D N-terminal truncation compared to Schu4 and U112 proteins; phosphoesterase family protein 162436..163911 Francisella tularensis subsp. holarctica FTNF002-00 5523102 YP_001427606.1 CDS FTA_0173 NC_009749.1 163918 164730 R biotin-dependent carboxylase complement(163918..164730) Francisella tularensis subsp. holarctica FTNF002-00 5523103 YP_001427608.2 CDS FTA_0175 NC_009749.1 165431 166048 R putative allophanate hydrolase subunit 1 complement(165431..166048) Francisella tularensis subsp. holarctica FTNF002-00 5523105 YP_001427611.2 CDS FTA_0178 NC_009749.1 167124 168004 R programmed robisomal frameshift; transposase ISFTu1 complement(join(167124..167675,167675..168004)) Francisella tularensis subsp. holarctica FTNF002-00 5523108 YP_001427614.1 CDS uspA NC_009749.1 168364 169200 R universal stress protein complement(168364..169200) Francisella tularensis subsp. holarctica FTNF002-00 5523111 YP_001427615.1 CDS FTA_0182 NC_009749.1 169276 172017 R DNA/RNA helicase complement(169276..172017) Francisella tularensis subsp. holarctica FTNF002-00 5523112 YP_001427616.1 CDS FTA_0183 NC_009749.1 172001 172780 R hypothetical protein complement(172001..172780) Francisella tularensis subsp. holarctica FTNF002-00 5523113 YP_001427617.2 CDS FTA_0184 NC_009749.1 172852 173415 R HAD superfamily phosphatase complement(172852..173415) Francisella tularensis subsp. holarctica FTNF002-00 5523919 YP_001427618.1 CDS FTA_0185 NC_009749.1 173491 173667 D hypothetical protein 173491..173667 Francisella tularensis subsp. holarctica FTNF002-00 5523920 YP_001427619.2 CDS FTA_0186 NC_009749.1 173756 174226 D hypothetical protein 173756..174226 Francisella tularensis subsp. holarctica FTNF002-00 5523921 YP_001427620.1 CDS FTA_0187 NC_009749.1 174237 175109 R tetrapyrrole (corrin/porphyrin) methylase family protein complement(174237..175109) Francisella tularensis subsp. holarctica FTNF002-00 5523922 YP_001427621.1 CDS murC NC_009749.1 175102 176457 R UDP-N-acetylmuramate--L-alanine ligase complement(175102..176457) Francisella tularensis subsp. holarctica FTNF002-00 5523923 YP_001427622.1 CDS aroE NC_009749.1 176524 177297 R shikimate 5-dehydrogenase complement(176524..177297) Francisella tularensis subsp. holarctica FTNF002-00 5523924 YP_001427623.1 CDS FTA_0190 NC_009749.1 177424 177882 D hypothetical protein 177424..177882 Francisella tularensis subsp. holarctica FTNF002-00 5523925 YP_001427624.1 CDS rpmH NC_009749.1 177974 178108 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 177974..178108 Francisella tularensis subsp. holarctica FTNF002-00 5523926 YP_001427625.1 CDS FTA_0192 NC_009749.1 178684 180339 D inner-membrane protein 178684..180339 Francisella tularensis subsp. holarctica FTNF002-00 5523927 YP_001427626.1 CDS FTA_0193 NC_009749.1 180346 181245 D lipid A biosynthesis acyltransferase 180346..181245 Francisella tularensis subsp. holarctica FTNF002-00 5523928 YP_001427627.1 CDS FTA_0194 NC_009749.1 181306 182229 D lipid A biosysnthsis acyltransferase 181306..182229 Francisella tularensis subsp. holarctica FTNF002-00 5523929 YP_001427628.1 CDS FTA_0195 NC_009749.1 182242 182649 D prepilin-type N-terminal cleavage/methylation domain-containing protein 182242..182649 Francisella tularensis subsp. holarctica FTNF002-00 5523930 YP_001427629.1 CDS efp NC_009749.1 182689 183258 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 182689..183258 Francisella tularensis subsp. holarctica FTNF002-00 5523931 YP_001427630.1 CDS FTA_0197 NC_009749.1 183261 183797 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 183261..183797 Francisella tularensis subsp. holarctica FTNF002-00 5524567 YP_001427631.1 CDS FTA_0198 NC_009749.1 183832 184026 D hypothetical protein 183832..184026 Francisella tularensis subsp. holarctica FTNF002-00 5524568 YP_001427632.2 CDS FTA_0199 NC_009749.1 184050 184930 D programmed ribosomal frameshift; transposase ISFTu1 join(184050..184379,184379..184930) Francisella tularensis subsp. holarctica FTNF002-00 5524569 YP_001427634.1 CDS FTA_0200 NC_009749.1 184908 186026 R major facilitator transporter complement(184908..186026) Francisella tularensis subsp. holarctica FTNF002-00 5524571 YP_001427635.1 CDS FTA_0202 NC_009749.1 186094 186834 R prediction using TransportDB and PF00497; ABC transporter perplasmic protein complement(186094..186834) Francisella tularensis subsp. holarctica FTNF002-00 5524573 YP_001427636.1 CDS cydB NC_009749.1 187027 188208 R cytochrome D ubiquinol oxidase subunit II complement(187027..188208) Francisella tularensis subsp. holarctica FTNF002-00 5524572 YP_001427637.2 CDS FTA_0204 NC_009749.1 188231 189985 R cytochrome D ubiquinol oxidase subunit 1 complement(188231..189985) Francisella tularensis subsp. holarctica FTNF002-00 5524574 YP_001427638.1 CDS FTA_0205 NC_009749.1 190438 191748 R major facilitator transporter complement(190438..191748) Francisella tularensis subsp. holarctica FTNF002-00 5524575 YP_001427639.1 CDS cyoA NC_009749.1 192165 193067 D cytochrome C oxidase /ubiquinol oxidase subunit II 192165..193067 Francisella tularensis subsp. holarctica FTNF002-00 5524576 YP_001427640.1 CDS cyoB NC_009749.1 193199 195136 D cytochrome C oxidase/ubiquinol oxidase subunit I 193199..195136 Francisella tularensis subsp. holarctica FTNF002-00 5524577 YP_001427641.1 CDS cyoC NC_009749.1 195133 195735 D cytochrome C oxidase/ubiquinol oxidase subunit III 195133..195735 Francisella tularensis subsp. holarctica FTNF002-00 5524578 YP_001427642.1 CDS cyoD NC_009749.1 195737 196069 D cytochrome C oxidase/ubiquinol oxidase subunit IV 195737..196069 Francisella tularensis subsp. holarctica FTNF002-00 5524579 YP_001427643.1 CDS cyoE NC_009749.1 196100 196948 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 196100..196948 Francisella tularensis subsp. holarctica FTNF002-00 5522742 YP_001427646.1 CDS FTA_0213 NC_009749.1 198203 198898 R radical SAM domain-containing protein complement(198203..198898) Francisella tularensis subsp. holarctica FTNF002-00 5522745 YP_001427647.1 CDS pdxY NC_009749.1 198898 199749 R pyridoxal kinase complement(198898..199749) Francisella tularensis subsp. holarctica FTNF002-00 5522746 YP_001427648.1 CDS FTA_0215 NC_009749.1 199756 200190 R hypothetical protein complement(199756..200190) Francisella tularensis subsp. holarctica FTNF002-00 5522747 YP_001427649.1 CDS FTA_0216 NC_009749.1 200336 201292 D methanol dehydrogenase regulatory protein 200336..201292 Francisella tularensis subsp. holarctica FTNF002-00 5522748 YP_001427650.1 CDS FTA_0217 NC_009749.1 201305 202216 D hypothetical protein 201305..202216 Francisella tularensis subsp. holarctica FTNF002-00 5522749 YP_001427651.1 CDS FTA_0218 NC_009749.1 202206 202682 D hypothetical protein 202206..202682 Francisella tularensis subsp. holarctica FTNF002-00 5522750 YP_001427652.1 CDS FTA_0219 NC_009749.1 202679 203680 D hypothetical protein 202679..203680 Francisella tularensis subsp. holarctica FTNF002-00 5522751 YP_001427653.2 CDS FTA_0220 NC_009749.1 203682 204680 D hypothetical protein 203682..204680 Francisella tularensis subsp. holarctica FTNF002-00 5522752 YP_001427654.1 CDS FTA_0221 NC_009749.1 204671 205351 D hypothetical protein 204671..205351 Francisella tularensis subsp. holarctica FTNF002-00 5522753 YP_001427655.1 CDS FTA_0222 NC_009749.1 205341 206966 D hypothetical protein 205341..206966 Francisella tularensis subsp. holarctica FTNF002-00 5522754 YP_001427656.2 CDS pcp NC_009749.1 206973 207641 D pyrrolidone-carboxylate peptidase 206973..207641 Francisella tularensis subsp. holarctica FTNF002-00 5524465 YP_001427657.1 CDS FTA_0224 NC_009749.1 207649 208131 D putative cytochrome c-type biogenesis protein 207649..208131 Francisella tularensis subsp. holarctica FTNF002-00 5524466 YP_001427658.1 CDS FTA_0225 NC_009749.1 208165 208602 D DNA polymerase III subunit chi 208165..208602 Francisella tularensis subsp. holarctica FTNF002-00 5524467 YP_001427659.1 CDS valS NC_009749.1 208734 211493 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 208734..211493 Francisella tularensis subsp. holarctica FTNF002-00 5524468 YP_001427660.1 CDS FTA_0227 NC_009749.1 211522 212409 D hypothetical protein 211522..212409 Francisella tularensis subsp. holarctica FTNF002-00 5524469 YP_001427661.1 CDS FTA_0228 NC_009749.1 212364 213350 D hypothetical protein 212364..213350 Francisella tularensis subsp. holarctica FTNF002-00 5524470 YP_001427662.1 CDS FTA_0230 NC_009749.1 213564 213845 D hypothetical protein 213564..213845 Francisella tularensis subsp. holarctica FTNF002-00 5524471 YP_001427663.1 CDS FTA_0229 NC_009749.1 213842 214999 R L-lactate dehydrogenase complement(213842..214999) Francisella tularensis subsp. holarctica FTNF002-00 5524472 YP_001427664.1 CDS FTA_0231 NC_009749.1 214989 215672 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(214989..215672) Francisella tularensis subsp. holarctica FTNF002-00 5524474 YP_001427665.2 CDS FTA_0232 NC_009749.1 215812 216189 D MutT/NUDIX family hydrolase 215812..216189 Francisella tularensis subsp. holarctica FTNF002-00 5524473 YP_001427666.1 CDS fumC NC_009749.1 216362 217753 D class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 216362..217753 Francisella tularensis subsp. holarctica FTNF002-00 5524475 YP_001427667.1 CDS gltX NC_009749.1 217883 219289 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 217883..219289 Francisella tularensis subsp. holarctica FTNF002-00 5524476 YP_001715623.1 CDS FTA_2142 NC_009749.1 219438 220253 D hypothetical protein 219438..220253 Francisella tularensis subsp. holarctica FTNF002-00 5983824 YP_001427671.1 CDS FTA_0238 NC_009749.1 223097 224020 R hypothetical protein complement(223097..224020) Francisella tularensis subsp. holarctica FTNF002-00 5523147 YP_001427672.1 CDS folA NC_009749.1 224102 224644 R dihydrofolate reductase type I complement(224102..224644) Francisella tularensis subsp. holarctica FTNF002-00 5524402 YP_001427673.2 CDS rpsB NC_009749.1 224837 225556 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 224837..225556 Francisella tularensis subsp. holarctica FTNF002-00 5523148 YP_001427674.1 CDS tsf NC_009749.1 225578 226447 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 225578..226447 Francisella tularensis subsp. holarctica FTNF002-00 5523149 YP_001427675.1 CDS pyrH NC_009749.1 226451 227200 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 226451..227200 Francisella tularensis subsp. holarctica FTNF002-00 5523150 YP_001427676.1 CDS frr NC_009749.1 227230 227787 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 227230..227787 Francisella tularensis subsp. holarctica FTNF002-00 5523151 YP_001427677.1 CDS uppS NC_009749.1 227871 228593 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 227871..228593 Francisella tularensis subsp. holarctica FTNF002-00 5523152 YP_001427678.1 CDS cdsA NC_009749.1 228607 229401 D phosphatidate cytidylyltransferase 228607..229401 Francisella tularensis subsp. holarctica FTNF002-00 5523153 YP_001427679.1 CDS dut NC_009749.1 229411 229857 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 229411..229857 Francisella tularensis subsp. holarctica FTNF002-00 5523154 YP_001427680.1 CDS pgsA NC_009749.1 229861 230457 D phosphatidylglycerophosphate synthetase 229861..230457 Francisella tularensis subsp. holarctica FTNF002-00 5523155 YP_001427681.1 CDS rpsL NC_009749.1 230592 230966 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 230592..230966 Francisella tularensis subsp. holarctica FTNF002-00 5523156 YP_001427682.1 CDS rpsG NC_009749.1 231005 231478 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 231005..231478 Francisella tularensis subsp. holarctica FTNF002-00 5523517 YP_001427683.1 CDS fusA NC_009749.1 231493 233607 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 231493..233607 Francisella tularensis subsp. holarctica FTNF002-00 5523518 YP_001427684.1 CDS rpsJ NC_009749.1 233628 233945 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 233628..233945 Francisella tularensis subsp. holarctica FTNF002-00 5523519 YP_001427685.1 CDS rplC NC_009749.1 234049 234681 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 234049..234681 Francisella tularensis subsp. holarctica FTNF002-00 5523520 YP_001427686.1 CDS rplD NC_009749.1 234714 235337 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 234714..235337 Francisella tularensis subsp. holarctica FTNF002-00 5523521 YP_001427687.1 CDS rplW NC_009749.1 235334 235633 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 235334..235633 Francisella tularensis subsp. holarctica FTNF002-00 5523522 YP_001427688.1 CDS rplB NC_009749.1 235655 236479 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 235655..236479 Francisella tularensis subsp. holarctica FTNF002-00 5523523 YP_001427689.1 CDS rpsS NC_009749.1 236494 236772 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 236494..236772 Francisella tularensis subsp. holarctica FTNF002-00 5523524 YP_001427690.1 CDS rplV NC_009749.1 236788 237123 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 236788..237123 Francisella tularensis subsp. holarctica FTNF002-00 5523525 YP_001427691.1 CDS rpsC NC_009749.1 237138 237809 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 237138..237809 Francisella tularensis subsp. holarctica FTNF002-00 5523526 YP_001427692.1 CDS rplP NC_009749.1 237809 238222 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 237809..238222 Francisella tularensis subsp. holarctica FTNF002-00 5523527 YP_003856785.1 CDS FTA_2200 NC_009749.1 238222 238422 D 50S ribosomal protein L29 238222..238422 Francisella tularensis subsp. holarctica FTNF002-00 9711849 YP_001427693.1 CDS rpsQ NC_009749.1 238435 238686 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 238435..238686 Francisella tularensis subsp. holarctica FTNF002-00 5523528 YP_001427694.1 CDS rplN NC_009749.1 238778 239146 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 238778..239146 Francisella tularensis subsp. holarctica FTNF002-00 5523529 YP_001427695.1 CDS rplX NC_009749.1 239168 239485 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 239168..239485 Francisella tularensis subsp. holarctica FTNF002-00 5522600 YP_001427696.1 CDS rplE NC_009749.1 239497 240036 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 239497..240036 Francisella tularensis subsp. holarctica FTNF002-00 5522601 YP_001427697.1 CDS rpsN NC_009749.1 240055 240360 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 240055..240360 Francisella tularensis subsp. holarctica FTNF002-00 5522602 YP_001427698.2 CDS rpsH NC_009749.1 240377 240775 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 240377..240775 Francisella tularensis subsp. holarctica FTNF002-00 5522603 YP_001427699.1 CDS rplF NC_009749.1 240794 241330 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 240794..241330 Francisella tularensis subsp. holarctica FTNF002-00 5522604 YP_001427700.1 CDS rplR NC_009749.1 241353 241706 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 241353..241706 Francisella tularensis subsp. holarctica FTNF002-00 5522605 YP_001427701.1 CDS rpsE NC_009749.1 241734 242234 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 241734..242234 Francisella tularensis subsp. holarctica FTNF002-00 5522606 YP_001427702.1 CDS rpmD NC_009749.1 242241 242426 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 242241..242426 Francisella tularensis subsp. holarctica FTNF002-00 5522607 YP_001427703.1 CDS rplO NC_009749.1 242433 242864 D late assembly protein; 50S ribosomal protein L15 242433..242864 Francisella tularensis subsp. holarctica FTNF002-00 5522608 YP_001427704.1 CDS secY NC_009749.1 242875 244200 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 242875..244200 Francisella tularensis subsp. holarctica FTNF002-00 5522609 YP_001427705.1 CDS rpsM NC_009749.1 244454 244810 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 244454..244810 Francisella tularensis subsp. holarctica FTNF002-00 5522610 YP_001427706.1 CDS rpsK NC_009749.1 244849 245238 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 244849..245238 Francisella tularensis subsp. holarctica FTNF002-00 5522611 YP_001427707.1 CDS rpsD NC_009749.1 245260 245880 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 245260..245880 Francisella tularensis subsp. holarctica FTNF002-00 5522612 YP_001427708.1 CDS rpoA1 NC_009749.1 245938 246909 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 245938..246909 Francisella tularensis subsp. holarctica FTNF002-00 5522700 YP_001427709.1 CDS rplQ NC_009749.1 246954 247391 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 246954..247391 Francisella tularensis subsp. holarctica FTNF002-00 5522701 YP_001427710.2 CDS FTA_0277 NC_009749.1 247545 248425 D programmed ribosomal frameshift; transposase ISFTu1 join(247545..247874,247874..248425) Francisella tularensis subsp. holarctica FTNF002-00 5522702 YP_001427712.2 CDS FTA_0279 NC_009749.1 248621 249616 R hypothetical protein complement(248621..249616) Francisella tularensis subsp. holarctica FTNF002-00 5522704 YP_001427714.2 CDS FTA_0281 NC_009749.1 250452 251278 R shorter ORF, programmed ribosomal frameshift; transposase ISFtu1 complement(join(250452..250949,250949..251278)) Francisella tularensis subsp. holarctica FTNF002-00 5522706 YP_001427716.1 CDS htpG NC_009749.1 251440 253326 D molecular chaperone; heat shock protein 90 251440..253326 Francisella tularensis subsp. holarctica FTNF002-00 5522708 YP_001427718.2 CDS FTA_0285 NC_009749.1 253556 254436 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(253556..254107,254107..254436)) Francisella tularensis subsp. holarctica FTNF002-00 5522710 YP_001427719.1 CDS FTA_0286 NC_009749.1 254628 255977 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(254628..255977) Francisella tularensis subsp. holarctica FTNF002-00 5522711 YP_001427720.1 CDS FTA_0287 NC_009749.1 256436 257125 D transposase ISFTu2 256436..257125 Francisella tularensis subsp. holarctica FTNF002-00 5522712 YP_001427721.1 CDS FTA_0288 NC_009749.1 257423 258013 D hypothetical protein 257423..258013 Francisella tularensis subsp. holarctica FTNF002-00 5523946 YP_001427722.1 CDS lysA NC_009749.1 258026 259195 D diaminopimelate decarboxylase 258026..259195 Francisella tularensis subsp. holarctica FTNF002-00 5523947 YP_001427723.1 CDS FTA_0290 NC_009749.1 259207 260586 D amino acid permease 259207..260586 Francisella tularensis subsp. holarctica FTNF002-00 5523948 YP_001427724.1 CDS FTA_0291 NC_009749.1 260628 260867 R hypothetical protein complement(260628..260867) Francisella tularensis subsp. holarctica FTNF002-00 5523949 YP_001427725.1 CDS FTA_0292 NC_009749.1 261063 261635 R methylated-DNA--protein-cysteine methyltransferase complement(261063..261635) Francisella tularensis subsp. holarctica FTNF002-00 5523950 YP_001427726.1 CDS FTA_0293 NC_009749.1 261665 262384 D hypothetical protein 261665..262384 Francisella tularensis subsp. holarctica FTNF002-00 5523951 YP_001427727.1 CDS FTA_0294 NC_009749.1 262387 263805 D pyridine nucleotide-disulfide oxidoreductase 262387..263805 Francisella tularensis subsp. holarctica FTNF002-00 5523952 YP_001427728.1 CDS FTA_0295 NC_009749.1 263802 264401 D CDP-alcohol phosphatidyltransferase 263802..264401 Francisella tularensis subsp. holarctica FTNF002-00 5523953 YP_001427729.1 CDS FTA_0296 NC_009749.1 264398 264727 D hypothetical protein 264398..264727 Francisella tularensis subsp. holarctica FTNF002-00 5523954 YP_001427730.1 CDS FTA_0297 NC_009749.1 264797 265513 R hypothetical protein complement(264797..265513) Francisella tularensis subsp. holarctica FTNF002-00 5523955 YP_001427731.1 CDS FTA_0299 NC_009749.1 265712 266638 D chaperone DnaJ domain-containing protein 265712..266638 Francisella tularensis subsp. holarctica FTNF002-00 5523956 YP_001427732.1 CDS FTA_0298 NC_009749.1 266628 267512 R drug/metabolite exporter family integral membrane protein complement(266628..267512) Francisella tularensis subsp. holarctica FTNF002-00 5523957 YP_001427733.1 CDS FTA_0300 NC_009749.1 267703 268899 D tryptophan/tyrosine permease family protein 267703..268899 Francisella tularensis subsp. holarctica FTNF002-00 5522558 YP_001427736.1 CDS FTA_0303 NC_009749.1 269659 271602 D putative GTP pyrophosphokinase 269659..271602 Francisella tularensis subsp. holarctica FTNF002-00 5522561 YP_001427737.1 CDS FTA_0304 NC_009749.1 271718 272350 R hypothetical protein complement(271718..272350) Francisella tularensis subsp. holarctica FTNF002-00 5524331 YP_001427738.1 CDS FTA_0305 NC_009749.1 272427 273005 R hypothetical protein complement(272427..273005) Francisella tularensis subsp. holarctica FTNF002-00 5522562 YP_001427739.1 CDS FTA_0306 NC_009749.1 273093 273707 D hypothetical protein 273093..273707 Francisella tularensis subsp. holarctica FTNF002-00 5522563 YP_001427740.1 CDS FTA_0307 NC_009749.1 273714 274439 R hypothetical protein complement(273714..274439) Francisella tularensis subsp. holarctica FTNF002-00 5522564 YP_001427741.1 CDS FTA_0308 NC_009749.1 274439 275317 R phage integrase family protein complement(274439..275317) Francisella tularensis subsp. holarctica FTNF002-00 5522565 YP_001427742.2 CDS FTA_0309 NC_009749.1 275327 276538 R aromatic amino acid transporter complement(275327..276538) Francisella tularensis subsp. holarctica FTNF002-00 5522566 YP_001427744.1 CDS secB2 NC_009749.1 277978 278421 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB complement(277978..278421) Francisella tularensis subsp. holarctica FTNF002-00 5522568 YP_001427745.1 CDS mutS NC_009749.1 278498 281032 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(278498..281032) Francisella tularensis subsp. holarctica FTNF002-00 5522569 YP_001427746.1 CDS accA NC_009749.1 281199 282146 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 281199..282146 Francisella tularensis subsp. holarctica FTNF002-00 5522570 YP_001427747.1 CDS FTA_0314 NC_009749.1 282166 282669 D hypothetical protein 282166..282669 Francisella tularensis subsp. holarctica FTNF002-00 5523775 YP_001427748.1 CDS FTA_0315 NC_009749.1 282650 283663 D hypothetical protein 282650..283663 Francisella tularensis subsp. holarctica FTNF002-00 5523776 YP_001427749.1 CDS FTA_0316 NC_009749.1 283672 285633 D hypothetical protein 283672..285633 Francisella tularensis subsp. holarctica FTNF002-00 5523777 YP_001427750.1 CDS murQ NC_009749.1 285630 286514 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 285630..286514 Francisella tularensis subsp. holarctica FTNF002-00 5523778 YP_001427751.1 CDS FTA_0318 NC_009749.1 286516 286911 D hypothetical protein 286516..286911 Francisella tularensis subsp. holarctica FTNF002-00 5523779 YP_001427752.1 CDS FTA_0319 NC_009749.1 287206 287334 R hypothetical protein complement(287206..287334) Francisella tularensis subsp. holarctica FTNF002-00 5523780 YP_001427753.1 CDS FTA_0320 NC_009749.1 287496 287948 D hypothetical protein 287496..287948 Francisella tularensis subsp. holarctica FTNF002-00 5523781 YP_001427754.1 CDS FTA_0321 NC_009749.1 288129 289298 D transposase ISFtu2 288129..289298 Francisella tularensis subsp. holarctica FTNF002-00 5523782 YP_001427755.2 CDS FTA_0322 NC_009749.1 289695 290993 R monovalent cation:proton antiporter family protein complement(289695..290993) Francisella tularensis subsp. holarctica FTNF002-00 5523783 YP_001427756.1 CDS FTA_0323 NC_009749.1 290803 290940 D hypothetical protein 290803..290940 Francisella tularensis subsp. holarctica FTNF002-00 5523784 YP_001427757.1 CDS FTA_0324 NC_009749.1 291003 291728 R hypothetical protein complement(291003..291728) Francisella tularensis subsp. holarctica FTNF002-00 5523785 YP_001427758.1 CDS trpS NC_009749.1 291730 292734 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(291730..292734) Francisella tularensis subsp. holarctica FTNF002-00 5523786 YP_001427759.1 CDS coaE NC_009749.1 293031 293645 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(293031..293645) Francisella tularensis subsp. holarctica FTNF002-00 5522977 YP_001427760.1 CDS FTA_0327 NC_009749.1 293774 294910 D hypothetical protein 293774..294910 Francisella tularensis subsp. holarctica FTNF002-00 5522982 YP_001427761.1 CDS aceE NC_009749.1 295194 297875 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 295194..297875 Francisella tularensis subsp. holarctica FTNF002-00 5524336 YP_001427762.1 CDS aceF NC_009749.1 297893 299488 D dihydrolipoamide acetyltransferase 297893..299488 Francisella tularensis subsp. holarctica FTNF002-00 5524337 YP_001427763.1 CDS lpdA NC_009749.1 299502 300914 D dihydrolipoamide dehydrogenase 299502..300914 Francisella tularensis subsp. holarctica FTNF002-00 5524338 YP_001427764.1 CDS FTA_0331 NC_009749.1 301153 301290 R putative transposase complement(301153..301290) Francisella tularensis subsp. holarctica FTNF002-00 5524339 YP_001427765.2 CDS FTA_0332 NC_009749.1 301284 302164 D programmed ribosomal frameshift; transposase ISFTu1 join(301284..301613,301613..302164) Francisella tularensis subsp. holarctica FTNF002-00 5524340 YP_001427767.2 CDS FTA_0334 NC_009749.1 302292 302939 D NUDIX family hydrolase 302292..302939 Francisella tularensis subsp. holarctica FTNF002-00 5524342 YP_001427768.1 CDS FTA_0335 NC_009749.1 302957 303310 D arsenate reductase 302957..303310 Francisella tularensis subsp. holarctica FTNF002-00 5524343 YP_001427769.1 CDS FTA_0336 NC_009749.1 303334 303669 R hypothetical protein complement(303334..303669) Francisella tularensis subsp. holarctica FTNF002-00 5524344 YP_001427770.1 CDS FTA_0337 NC_009749.1 303997 304146 D hypothetical protein 303997..304146 Francisella tularensis subsp. holarctica FTNF002-00 5524345 YP_001427771.1 CDS FTA_0338 NC_009749.1 304169 305482 R xanthine/uracil permease family protein complement(304169..305482) Francisella tularensis subsp. holarctica FTNF002-00 5524346 YP_001427772.1 CDS FTA_0339 NC_009749.1 305549 307135 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(305549..307135) Francisella tularensis subsp. holarctica FTNF002-00 5524347 YP_001427773.1 CDS FTA_0340 NC_009749.1 307291 307428 D hypothetical protein 307291..307428 Francisella tularensis subsp. holarctica FTNF002-00 5523987 YP_001427775.1 CDS FTA_0342 NC_009749.1 308478 308699 D hypothetical protein 308478..308699 Francisella tularensis subsp. holarctica FTNF002-00 5523989 YP_001427776.1 CDS FTA_0343 NC_009749.1 308734 308865 D hypothetical protein 308734..308865 Francisella tularensis subsp. holarctica FTNF002-00 5523990 YP_001427779.2 CDS FTA_0346 NC_009749.1 310117 311370 R OmpA family protein complement(310117..311370) Francisella tularensis subsp. holarctica FTNF002-00 5523993 YP_001427780.1 CDS FTA_0347 NC_009749.1 311562 312026 D FKBP-type peptidyl-prolyl cis-trans isomerase 311562..312026 Francisella tularensis subsp. holarctica FTNF002-00 5523994 YP_001427781.1 CDS ispH NC_009749.1 312007 312963 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 312007..312963 Francisella tularensis subsp. holarctica FTNF002-00 5523995 YP_001427782.1 CDS aroH NC_009749.1 312965 313327 D chorismate mutase 312965..313327 Francisella tularensis subsp. holarctica FTNF002-00 5523996 YP_001427783.1 CDS pssA NC_009749.1 313336 314157 D CDP-alcohol phosphatidyltransferase 313336..314157 Francisella tularensis subsp. holarctica FTNF002-00 5523997 YP_001427784.1 CDS FTA_0351 NC_009749.1 314162 314368 R hypothetical protein complement(314162..314368) Francisella tularensis subsp. holarctica FTNF002-00 5523998 YP_001427785.1 CDS tolQ NC_009749.1 314538 315245 D TolQ protein 314538..315245 Francisella tularensis subsp. holarctica FTNF002-00 5523999 YP_001427786.1 CDS tolR NC_009749.1 315363 315701 D TolR protein 315363..315701 Francisella tularensis subsp. holarctica FTNF002-00 5523073 YP_001427787.1 CDS tolA NC_009749.1 315688 316599 D tol-pal system component, TolA 315688..316599 Francisella tularensis subsp. holarctica FTNF002-00 5523074 YP_001427788.2 CDS tolB NC_009749.1 316599 317918 D tol-pal system component, TolB protein 316599..317918 Francisella tularensis subsp. holarctica FTNF002-00 5523075 YP_001427789.2 CDS FTA_0356 NC_009749.1 317922 318173 D lipoprotein 317922..318173 Francisella tularensis subsp. holarctica FTNF002-00 5523076 YP_001427790.2 CDS pal NC_009749.1 318192 318815 D OmpA family peptidoglycan-associated lipoprotein 318192..318815 Francisella tularensis subsp. holarctica FTNF002-00 5523077 YP_001427791.1 CDS rimO NC_009749.1 318922 320217 D catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 318922..320217 Francisella tularensis subsp. holarctica FTNF002-00 5523078 YP_001427792.1 CDS FTA_0359 NC_009749.1 320226 320576 D acetyltransferase 320226..320576 Francisella tularensis subsp. holarctica FTNF002-00 5523079 YP_001427793.2 CDS FTA_0360 NC_009749.1 320722 321602 D programmed ribosomal frameshift; transposase ISFTu1 join(320722..321051,321051..321602) Francisella tularensis subsp. holarctica FTNF002-00 5523080 YP_001427797.1 CDS FTA_0364 NC_009749.1 323263 324792 D deoxyribodipyrimidine photolyase-like protein 323263..324792 Francisella tularensis subsp. holarctica FTNF002-00 5523084 YP_001427798.2 CDS FTA_0365 NC_009749.1 325052 325984 D sodium dependent symporter family protein 325052..325984 Francisella tularensis subsp. holarctica FTNF002-00 5523086 YP_001427802.1 CDS FTA_0369 NC_009749.1 327972 328958 D hypothetical protein 327972..328958 Francisella tularensis subsp. holarctica FTNF002-00 5524526 YP_001427805.2 CDS FTA_0372 NC_009749.1 330346 330771 R hypothetical protein complement(330346..330771) Francisella tularensis subsp. holarctica FTNF002-00 5524528 YP_001427806.2 CDS FTA_0373 NC_009749.1 330743 331623 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(330743..331294,331294..331623)) Francisella tularensis subsp. holarctica FTNF002-00 5524529 YP_001427808.1 CDS FTA_0375 NC_009749.1 331741 332100 R hypothetical protein complement(331741..332100) Francisella tularensis subsp. holarctica FTNF002-00 5524531 YP_001427809.1 CDS ubiA NC_009749.1 332097 332966 R UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; 4-hydroxybenzoate polyprenyltransferase complement(332097..332966) Francisella tularensis subsp. holarctica FTNF002-00 5524532 YP_001427810.1 CDS ubiC NC_009749.1 332969 333475 R chorismate pyruvate lyase complement(332969..333475) Francisella tularensis subsp. holarctica FTNF002-00 5524533 YP_001427811.1 CDS rph NC_009749.1 333574 334281 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 333574..334281 Francisella tularensis subsp. holarctica FTNF002-00 5524534 YP_001427812.1 CDS FTA_0379 NC_009749.1 334335 334658 R hypothetical protein complement(334335..334658) Francisella tularensis subsp. holarctica FTNF002-00 5524536 YP_001427814.1 CDS FTA_0381 NC_009749.1 335035 335670 R prepilin-type N-terminal cleavage/methylation domain-containing protein complement(335035..335670) Francisella tularensis subsp. holarctica FTNF002-00 5523973 YP_001427815.1 CDS FTA_0382 NC_009749.1 335775 336848 R putative metalloprotease; heat shock protein HtpX complement(335775..336848) Francisella tularensis subsp. holarctica FTNF002-00 5523974 YP_001427816.1 CDS FTA_0383 NC_009749.1 336852 337427 R LemA-like protein complement(336852..337427) Francisella tularensis subsp. holarctica FTNF002-00 5523975 YP_001427824.1 CDS FTA_0391 NC_009749.1 342583 342948 R ArsR family transcriptional regulator complement(342583..342948) Francisella tularensis subsp. holarctica FTNF002-00 5523983 YP_001427825.1 CDS FTA_0392 NC_009749.1 343091 343744 D hypothetical protein 343091..343744 Francisella tularensis subsp. holarctica FTNF002-00 5523984 YP_001427826.1 CDS FTA_0393 NC_009749.1 343756 343887 R hypothetical protein complement(343756..343887) Francisella tularensis subsp. holarctica FTNF002-00 5523986 YP_001427827.1 CDS FTA_0394 NC_009749.1 343889 344026 D hypothetical protein 343889..344026 Francisella tularensis subsp. holarctica FTNF002-00 5523985 YP_001427828.1 CDS gpsA NC_009749.1 344064 345062 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 344064..345062 Francisella tularensis subsp. holarctica FTNF002-00 5522859 YP_001427829.2 CDS FTA_0396 NC_009749.1 345063 345599 R colicin V production (CvpA) family protein complement(345063..345599) Francisella tularensis subsp. holarctica FTNF002-00 5522860 YP_001427830.1 CDS radA NC_009749.1 345604 346974 R Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA complement(345604..346974) Francisella tularensis subsp. holarctica FTNF002-00 5522861 YP_001427831.1 CDS FTA_0398 NC_009749.1 346982 347752 R hypothetical protein complement(346982..347752) Francisella tularensis subsp. holarctica FTNF002-00 5522862 YP_001427832.1 CDS FTA_0399 NC_009749.1 347749 348348 R hypothetical protein complement(347749..348348) Francisella tularensis subsp. holarctica FTNF002-00 5522863 YP_001427833.1 CDS aroC NC_009749.1 348351 349409 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(348351..349409) Francisella tularensis subsp. holarctica FTNF002-00 5522864 YP_001427834.1 CDS FTA_0401 NC_009749.1 349550 350203 R PQ loop repeat-containing membrane protein complement(349550..350203) Francisella tularensis subsp. holarctica FTNF002-00 5522865 YP_001427835.1 CDS msrB NC_009749.1 350222 350734 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(350222..350734) Francisella tularensis subsp. holarctica FTNF002-00 5522866 YP_001427836.1 CDS sodC NC_009749.1 350895 351452 D copper/zinc superoxide dismutase 350895..351452 Francisella tularensis subsp. holarctica FTNF002-00 5522867 YP_001427837.1 CDS FTA_0405 NC_009749.1 351456 352247 D hypothetical protein 351456..352247 Francisella tularensis subsp. holarctica FTNF002-00 5522868 YP_001427838.1 CDS FTA_0404 NC_009749.1 352222 353616 R amino acid permease complement(352222..353616) Francisella tularensis subsp. holarctica FTNF002-00 5522869 YP_001427839.1 CDS FTA_0406 NC_009749.1 353766 354128 D mannose-6-phosphate isomerase 353766..354128 Francisella tularensis subsp. holarctica FTNF002-00 5522871 YP_001427843.1 CDS FTA_0410 NC_009749.1 355367 356557 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(355367..356557) Francisella tularensis subsp. holarctica FTNF002-00 5524190 YP_001427844.1 CDS FTA_0411 NC_009749.1 356760 357647 D cation transporter 356760..357647 Francisella tularensis subsp. holarctica FTNF002-00 5524191 YP_001427845.1 CDS recN NC_009749.1 357733 359382 D DNA repair protein RecN 357733..359382 Francisella tularensis subsp. holarctica FTNF002-00 5524192 YP_001427848.1 CDS FTA_0415 NC_009749.1 362144 362551 R type IV pilus assembly protein complement(362144..362551) Francisella tularensis subsp. holarctica FTNF002-00 5524195 YP_001427849.1 CDS FTA_0416 NC_009749.1 362935 363654 D PAP2 (2 phosphatidic acid phosphatase) family protein 362935..363654 Francisella tularensis subsp. holarctica FTNF002-00 5524196 YP_001427850.1 CDS FTA_0417 NC_009749.1 363794 364642 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 363794..364642 Francisella tularensis subsp. holarctica FTNF002-00 5524197 YP_001427851.1 CDS purM NC_009749.1 364862 365905 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 364862..365905 Francisella tularensis subsp. holarctica FTNF002-00 5524198 YP_001427852.1 CDS purCD NC_009749.1 365905 368217 D multifunctional fusion protein; phosphoribosylaminoimidazole-succinocarboxamide synthase/phosphoribosylamine-glycine ligase 365905..368217 Francisella tularensis subsp. holarctica FTNF002-00 5524199 YP_001427853.1 CDS purN NC_009749.1 368221 368796 D phosphoribosylglycinamide formyltransferase 368221..368796 Francisella tularensis subsp. holarctica FTNF002-00 5524200 YP_001427854.1 CDS purE NC_009749.1 368913 369404 D phosphoribosylaminoimidazole carboxylase catalytic subunit 368913..369404 Francisella tularensis subsp. holarctica FTNF002-00 5524202 YP_001427855.1 CDS purK NC_009749.1 369408 370505 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 369408..370505 Francisella tularensis subsp. holarctica FTNF002-00 5524201 YP_001427856.1 CDS FTA_0423 NC_009749.1 370682 371335 R N-terminal truncated due to in-frame stop; transposase, ISFTu2 complement(370682..371335) Francisella tularensis subsp. holarctica FTNF002-00 5523574 YP_001427858.1 CDS ispZ NC_009749.1 371942 372472 D intracellular septation protein A family protein 371942..372472 Francisella tularensis subsp. holarctica FTNF002-00 5523576 YP_001427859.1 CDS glk NC_009749.1 372786 373802 R glucokinase complement(372786..373802) Francisella tularensis subsp. holarctica FTNF002-00 5523577 YP_001427860.1 CDS ubiE NC_009749.1 373896 374648 D menaquinone biosynthesis methyltransferase 373896..374648 Francisella tularensis subsp. holarctica FTNF002-00 5523578 YP_001427861.1 CDS FTA_0428 NC_009749.1 374650 375237 D hypothetical protein 374650..375237 Francisella tularensis subsp. holarctica FTNF002-00 5523579 YP_001427862.2 CDS ubiB NC_009749.1 375230 376888 D 2-polyprenylphenol 6-hydroxylase 375230..376888 Francisella tularensis subsp. holarctica FTNF002-00 5523580 YP_001427863.1 CDS FTA_0430 NC_009749.1 376894 377232 D histidine triad domain-containing protein 376894..377232 Francisella tularensis subsp. holarctica FTNF002-00 5523581 YP_001427864.1 CDS FTA_0431 NC_009749.1 377249 377380 R hypothetical protein complement(377249..377380) Francisella tularensis subsp. holarctica FTNF002-00 5523582 YP_001427865.1 CDS FTA_0432 NC_009749.1 377747 378400 R amidophosphoribosyltransferase/comF family protein complement(377747..378400) Francisella tularensis subsp. holarctica FTNF002-00 5523583 YP_001427866.1 CDS FTA_0433 NC_009749.1 378378 379205 D hypothetical protein 378378..379205 Francisella tularensis subsp. holarctica FTNF002-00 5523584 YP_001427867.1 CDS FTA_0434 NC_009749.1 379207 380082 R hypothetical protein complement(379207..380082) Francisella tularensis subsp. holarctica FTNF002-00 5523585 YP_001427868.1 CDS murB NC_009749.1 380161 381009 R UDP-N-acetylenolpyruvoylglucosamine reductase complement(380161..381009) Francisella tularensis subsp. holarctica FTNF002-00 5523587 YP_001427869.1 CDS murA NC_009749.1 381017 382321 R UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(381017..382321) Francisella tularensis subsp. holarctica FTNF002-00 5523586 YP_001427870.1 CDS engA NC_009749.1 382290 383687 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(382290..383687) Francisella tularensis subsp. holarctica FTNF002-00 5523172 YP_001427871.1 CDS FTA_0438 NC_009749.1 383924 384442 R hypothetical protein complement(383924..384442) Francisella tularensis subsp. holarctica FTNF002-00 5523173 YP_001427872.1 CDS FTA_0439 NC_009749.1 384669 385508 D N-terminal truncated due to in-frame stop; transposase, ISFTu2 384669..385508 Francisella tularensis subsp. holarctica FTNF002-00 5523174 YP_001427875.1 CDS FTA_0442 NC_009749.1 386505 388511 R M3 family oligopeptidase complement(386505..388511) Francisella tularensis subsp. holarctica FTNF002-00 5523177 YP_001427876.1 CDS FTA_0443 NC_009749.1 388603 388974 D hypothetical protein 388603..388974 Francisella tularensis subsp. holarctica FTNF002-00 5523178 YP_001427877.1 CDS FTA_0444 NC_009749.1 389055 389504 D lipoprotein 389055..389504 Francisella tularensis subsp. holarctica FTNF002-00 5523179 YP_001427878.2 CDS FTA_0445 NC_009749.1 390165 390668 D hypothetical protein 390165..390668 Francisella tularensis subsp. holarctica FTNF002-00 5523180 YP_001427879.2 CDS FTA_0446 NC_009749.1 390701 391168 D lipoprotein 390701..391168 Francisella tularensis subsp. holarctica FTNF002-00 5523181 YP_001427880.1 CDS FTA_0447 NC_009749.1 391241 392683 D O antigen polymerase 391241..392683 Francisella tularensis subsp. holarctica FTNF002-00 5523182 YP_001427881.1 CDS topA NC_009749.1 392737 395031 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining; maintains net negative superhelicity; DNA topoisomerase I complement(392737..395031) Francisella tularensis subsp. holarctica FTNF002-00 5523183 YP_001427882.1 CDS FTA_0449 NC_009749.1 395230 395871 D ParA domain-containing protein 395230..395871 Francisella tularensis subsp. holarctica FTNF002-00 5523185 YP_001427883.2 CDS FTA_0450 NC_009749.1 395864 396778 D parB-like nuclease domain-containing protein 395864..396778 Francisella tularensis subsp. holarctica FTNF002-00 5523184 YP_001427884.1 CDS FTA_0451 NC_009749.1 396792 397499 D glutamine amidotransferase 396792..397499 Francisella tularensis subsp. holarctica FTNF002-00 5524073 YP_001427885.1 CDS FTA_0452 NC_009749.1 397502 398383 D hypothetical protein 397502..398383 Francisella tularensis subsp. holarctica FTNF002-00 5524074 YP_001427888.1 CDS rrmJ NC_009749.1 399030 399650 R ribosomal large subunit methyltransferase J complement(399030..399650) Francisella tularensis subsp. holarctica FTNF002-00 5524077 YP_001427889.2 CDS FTA_0457 NC_009749.1 399808 400275 D hypothetical protein 399808..400275 Francisella tularensis subsp. holarctica FTNF002-00 5524078 YP_001427890.1 CDS lspA NC_009749.1 400270 400734 R lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase complement(400270..400734) Francisella tularensis subsp. holarctica FTNF002-00 5524079 YP_001427891.1 CDS ileS NC_009749.1 400742 403549 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(400742..403549) Francisella tularensis subsp. holarctica FTNF002-00 5524081 YP_001427892.1 CDS ribF NC_009749.1 403642 404562 R riboflavin biosynthesis protein RibF complement(403642..404562) Francisella tularensis subsp. holarctica FTNF002-00 5524080 YP_001427893.1 CDS FTA_0460 NC_009749.1 404713 406527 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 404713..406527 Francisella tularensis subsp. holarctica FTNF002-00 5524082 YP_001427894.1 CDS FTA_0461 NC_009749.1 406693 408363 D lipoprotein 406693..408363 Francisella tularensis subsp. holarctica FTNF002-00 5524083 YP_001427895.1 CDS FTA_0462 NC_009749.1 408380 409825 D hypothetical protein 408380..409825 Francisella tularensis subsp. holarctica FTNF002-00 5524084 YP_001427896.2 CDS FTA_0463 NC_009749.1 409944 410773 D programmed ribosomal frameshift; transposase, ISFTu1 join(409944..410273,410273..410773) Francisella tularensis subsp. holarctica FTNF002-00 5524086 YP_001427899.1 CDS FTA_0467 NC_009749.1 411940 412542 D hypothetical protein 411940..412542 Francisella tularensis subsp. holarctica FTNF002-00 5523633 YP_001427900.1 CDS FTA_0466 NC_009749.1 412539 413762 R major facilitator transporter complement(412539..413762) Francisella tularensis subsp. holarctica FTNF002-00 5523634 YP_001427901.2 CDS metG NC_009749.1 413779 415803 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(413779..415803) Francisella tularensis subsp. holarctica FTNF002-00 5523636 YP_001427902.1 CDS FTA_0469 NC_009749.1 416373 416909 R FMN reductase, NADPH-dependent complement(416373..416909) Francisella tularensis subsp. holarctica FTNF002-00 5524656 YP_001427905.1 CDS FTA_0473 NC_009749.1 423679 424734 R extracellular ligand binding domain-containing protein complement(423679..424734) Francisella tularensis subsp. holarctica FTNF002-00 5523640 YP_001427906.2 CDS FTA_0474 NC_009749.1 424848 425504 R M50 family peptidase complement(424848..425504) Francisella tularensis subsp. holarctica FTNF002-00 5523641 YP_001427907.1 CDS FTA_0475 NC_009749.1 425757 425885 D hypothetical protein 425757..425885 Francisella tularensis subsp. holarctica FTNF002-00 5523642 YP_001427908.1 CDS FTA_0477 NC_009749.1 426708 427043 D hypothetical protein 426708..427043 Francisella tularensis subsp. holarctica FTNF002-00 5523643 YP_001427909.1 CDS psd NC_009749.1 427016 427867 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(427016..427867) Francisella tularensis subsp. holarctica FTNF002-00 5523645 YP_001427910.2 CDS FTA_0478 NC_009749.1 427967 428947 D hypothetical protein 427967..428947 Francisella tularensis subsp. holarctica FTNF002-00 5523644 YP_001427911.1 CDS FTA_0479 NC_009749.1 428956 429999 D NadM-Nudix subfamily; involved in creation of nicotanimide adenine dinucleotide NAD from either biosynthetic or salvage pathways; bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase 428956..429999 Francisella tularensis subsp. holarctica FTNF002-00 5522917 YP_001427912.1 CDS glmU NC_009749.1 430013 431380 D UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase 430013..431380 Francisella tularensis subsp. holarctica FTNF002-00 5522918 YP_001427913.1 CDS glmS NC_009749.1 431401 433239 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 431401..433239 Francisella tularensis subsp. holarctica FTNF002-00 5522919 YP_001427914.2 CDS FTA_0483 NC_009749.1 433323 433844 D acetyltransferase 433323..433844 Francisella tularensis subsp. holarctica FTNF002-00 5522920 YP_001427915.1 CDS rpsU NC_009749.1 433841 434038 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(433841..434038) Francisella tularensis subsp. holarctica FTNF002-00 5522922 YP_001427916.1 CDS FTA_0484 NC_009749.1 434038 434241 R cold-shock DNA-binding domain-containing protein complement(434038..434241) Francisella tularensis subsp. holarctica FTNF002-00 5522921 YP_001427917.1 CDS FTA_0485 NC_009749.1 434488 434817 R MazG nucleotide pyrophosphohydrolase domain-containing protein complement(434488..434817) Francisella tularensis subsp. holarctica FTNF002-00 5522923 YP_001427918.1 CDS map NC_009749.1 434944 435714 D methionine aminopeptidase 434944..435714 Francisella tularensis subsp. holarctica FTNF002-00 5522924 YP_001427919.1 CDS FTA_0487 NC_009749.1 435716 436564 D hypothetical protein 435716..436564 Francisella tularensis subsp. holarctica FTNF002-00 5522925 YP_001427920.1 CDS FTA_0488 NC_009749.1 436649 437323 D DNA repair ATPase 436649..437323 Francisella tularensis subsp. holarctica FTNF002-00 5522926 YP_001427921.2 CDS parC NC_009749.1 437456 439681 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 437456..439681 Francisella tularensis subsp. holarctica FTNF002-00 5522927 YP_001427922.1 CDS mtnN NC_009749.1 439681 440367 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 439681..440367 Francisella tularensis subsp. holarctica FTNF002-00 5522928 YP_001427923.1 CDS FTA_0490 NC_009749.1 440354 440953 R hypothetical protein complement(440354..440953) Francisella tularensis subsp. holarctica FTNF002-00 5522930 YP_001427924.1 CDS FTA_0492 NC_009749.1 440946 442064 R BNR/Asp-box repeat-containing neuramidase complement(440946..442064) Francisella tularensis subsp. holarctica FTNF002-00 5522929 YP_001427925.1 CDS FTA_0493 NC_009749.1 442296 444239 D lytic murein transglycosylase 442296..444239 Francisella tularensis subsp. holarctica FTNF002-00 5523202 YP_001427928.2 CDS FTA_0496 NC_009749.1 446102 446485 D hypothetical protein 446102..446485 Francisella tularensis subsp. holarctica FTNF002-00 5523205 YP_001427930.1 CDS dnaE NC_009749.1 447613 451092 D DNA polymerase III subunit alpha 447613..451092 Francisella tularensis subsp. holarctica FTNF002-00 5523207 YP_001427931.1 CDS def2 NC_009749.1 451171 451803 D peptide deformylase 451171..451803 Francisella tularensis subsp. holarctica FTNF002-00 5523208 YP_001427932.1 CDS FTA_0500 NC_009749.1 452466 453770 D LolC/E family lipoprotein releasing system, transmembrane protein 452466..453770 Francisella tularensis subsp. holarctica FTNF002-00 5524151 YP_001427933.1 CDS lolD NC_009749.1 453763 454458 D lipoprotein-releasing system, ATP-binding protein 453763..454458 Francisella tularensis subsp. holarctica FTNF002-00 5523210 YP_001427934.1 CDS FTA_0502 NC_009749.1 454575 456716 D Orn/Lys/Arg decarboxylase 454575..456716 Francisella tularensis subsp. holarctica FTNF002-00 5523211 YP_001427935.1 CDS gcvT NC_009749.1 456808 457884 D catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 456808..457884 Francisella tularensis subsp. holarctica FTNF002-00 5523212 YP_001427936.1 CDS gcvH1 NC_009749.1 457941 458324 D glycine cleavage system H protein 457941..458324 Francisella tularensis subsp. holarctica FTNF002-00 5523213 YP_001427937.1 CDS gcvP1 NC_009749.1 458389 459756 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein; glycine dehydrogenase subunit 1 458389..459756 Francisella tularensis subsp. holarctica FTNF002-00 5523214 YP_001427938.1 CDS gcvP2 NC_009749.1 459762 461207 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein; glycine dehydrogenase subunit 2 459762..461207 Francisella tularensis subsp. holarctica FTNF002-00 5523215 YP_001427939.1 CDS FTA_0507 NC_009749.1 461327 462172 R shikimate 5-dehydrogenase complement(461327..462172) Francisella tularensis subsp. holarctica FTNF002-00 5522903 YP_001427940.1 CDS pulA NC_009749.1 462198 465410 R pullulanase Type I complement(462198..465410) Francisella tularensis subsp. holarctica FTNF002-00 5522904 YP_001427941.1 CDS glgB NC_009749.1 465444 467366 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(465444..467366) Francisella tularensis subsp. holarctica FTNF002-00 5522905 YP_001427942.1 CDS FTA_0510 NC_009749.1 467668 469302 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 467668..469302 Francisella tularensis subsp. holarctica FTNF002-00 5522906 YP_001427943.1 CDS glgC NC_009749.1 469336 470607 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 469336..470607 Francisella tularensis subsp. holarctica FTNF002-00 5522907 YP_001427944.1 CDS glgA NC_009749.1 470617 472086 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 470617..472086 Francisella tularensis subsp. holarctica FTNF002-00 5522908 YP_001427945.1 CDS glgP NC_009749.1 472191 474464 D glycogen/starch/alpha-glucan phosphorylase 472191..474464 Francisella tularensis subsp. holarctica FTNF002-00 5522909 YP_001427946.2 CDS malQ NC_009749.1 474508 475971 D amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 474508..475971 Francisella tularensis subsp. holarctica FTNF002-00 5522910 YP_001427947.1 CDS glyQ NC_009749.1 476063 476953 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 476063..476953 Francisella tularensis subsp. holarctica FTNF002-00 5522911 YP_001427948.1 CDS FTA_0516 NC_009749.1 477164 478627 D UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 477164..478627 Francisella tularensis subsp. holarctica FTNF002-00 5522912 YP_001427949.1 CDS FTA_0517 NC_009749.1 478649 479044 D lipoprotein 478649..479044 Francisella tularensis subsp. holarctica FTNF002-00 5522913 YP_001427950.1 CDS FTA_0518 NC_009749.1 479397 480755 D UDP-N--acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 479397..480755 Francisella tularensis subsp. holarctica FTNF002-00 5522914 YP_001427951.1 CDS FTA_0519 NC_009749.1 480764 481582 D hypothetical protein 480764..481582 Francisella tularensis subsp. holarctica FTNF002-00 5522915 YP_001427952.1 CDS asd NC_009749.1 481631 482671 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(481631..482671) Francisella tularensis subsp. holarctica FTNF002-00 5522916 YP_001427953.1 CDS FTA_0521 NC_009749.1 482970 483827 D N-terminal and C-terminal truncation comapred to other Francisella species; amino acid kinase family protein 482970..483827 Francisella tularensis subsp. holarctica FTNF002-00 5523845 YP_001427954.1 CDS FTA_0522 NC_009749.1 483988 484638 D N-terminal truncation comapred to other Francisella species; putative GHMP kinases ATP-binding protein 483988..484638 Francisella tularensis subsp. holarctica FTNF002-00 5523846 YP_001427955.1 CDS thrC NC_009749.1 484651 485943 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 484651..485943 Francisella tularensis subsp. holarctica FTNF002-00 5523847 YP_001427956.1 CDS FTA_0524 NC_009749.1 486531 487019 D S-adenosylmethionine decarboxylase 486531..487019 Francisella tularensis subsp. holarctica FTNF002-00 5523848 YP_001427957.1 CDS speE NC_009749.1 487019 487888 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 487019..487888 Francisella tularensis subsp. holarctica FTNF002-00 5523849 YP_001427961.2 CDS FTA_0529 NC_009749.1 490405 491285 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(490405..490956,490956..491285)) Francisella tularensis subsp. holarctica FTNF002-00 5523853 YP_001427966.1 CDS lpxH NC_009749.1 492359 493075 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(492359..493075) Francisella tularensis subsp. holarctica FTNF002-00 5523858 YP_001427967.1 CDS pyrE NC_009749.1 493065 493775 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(493065..493775) Francisella tularensis subsp. holarctica FTNF002-00 5522642 YP_001427968.1 CDS mpl NC_009749.1 493851 495221 D UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 493851..495221 Francisella tularensis subsp. holarctica FTNF002-00 5522643 YP_001427969.1 CDS FTA_0538 NC_009749.1 495218 495874 D RNA methyltransferase 495218..495874 Francisella tularensis subsp. holarctica FTNF002-00 5522644 YP_001427970.2 CDS FTA_0537 NC_009749.1 495852 496732 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(495852..496403,496403..496732)) Francisella tularensis subsp. holarctica FTNF002-00 5522646 YP_001427973.1 CDS FTA_0541 NC_009749.1 497942 498178 R BolA -like protein complement(497942..498178) Francisella tularensis subsp. holarctica FTNF002-00 5522648 YP_001427974.1 CDS FTA_0542 NC_009749.1 498195 498488 R hypothetical protein complement(498195..498488) Francisella tularensis subsp. holarctica FTNF002-00 5522649 YP_001427975.2 CDS ttg2 NC_009749.1 498488 499150 R organic solvent resistance ABC transporter complement(498488..499150) Francisella tularensis subsp. holarctica FTNF002-00 5522650 YP_001427976.2 CDS FTA_0544 NC_009749.1 499225 499758 R ABC transporter periplasmic protein complement(499225..499758) Francisella tularensis subsp. holarctica FTNF002-00 5522651 YP_001427977.2 CDS ttg2B NC_009749.1 499758 500522 R toluene tolerance protein complement(499758..500522) Francisella tularensis subsp. holarctica FTNF002-00 5522652 YP_001427978.1 CDS FTA_0546 NC_009749.1 500526 501329 R ABC transporter ATP-binding protein complement(500526..501329) Francisella tularensis subsp. holarctica FTNF002-00 5522653 YP_001427979.1 CDS minE NC_009749.1 501343 501615 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(501343..501615) Francisella tularensis subsp. holarctica FTNF002-00 5522654 YP_001427980.1 CDS minD NC_009749.1 501618 502442 R septum site-determining protein MinD complement(501618..502442) Francisella tularensis subsp. holarctica FTNF002-00 5524157 YP_001427981.1 CDS minC NC_009749.1 502482 503168 R septum site-determining protein MinC complement(502482..503168) Francisella tularensis subsp. holarctica FTNF002-00 5522529 YP_001427982.1 CDS rpmG NC_009749.1 503203 503358 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(503203..503358) Francisella tularensis subsp. holarctica FTNF002-00 5522530 YP_001427983.1 CDS rpmB NC_009749.1 503385 503621 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(503385..503621) Francisella tularensis subsp. holarctica FTNF002-00 5522531 YP_001427984.1 CDS FTA_0552 NC_009749.1 503755 504099 R hypothetical protein complement(503755..504099) Francisella tularensis subsp. holarctica FTNF002-00 5522532 YP_001427985.1 CDS FTA_0553 NC_009749.1 504229 506268 D ATP-dependent DNA helicase RecG 504229..506268 Francisella tularensis subsp. holarctica FTNF002-00 5522533 YP_001427986.1 CDS FTA_0554 NC_009749.1 506326 506469 D hypothetical protein 506326..506469 Francisella tularensis subsp. holarctica FTNF002-00 5522534 YP_001427987.1 CDS FTA_0555 NC_009749.1 507023 508537 D fumerate hydratase 507023..508537 Francisella tularensis subsp. holarctica FTNF002-00 5522535 YP_001427988.1 CDS FTA_0556 NC_009749.1 508541 508681 D hypothetical protein 508541..508681 Francisella tularensis subsp. holarctica FTNF002-00 5522536 YP_001427989.2 CDS FTA_0557 NC_009749.1 509021 509739 D programmed ribosomal frameshift; transposase ISFTu1 join(509021..509350,509350..509739) Francisella tularensis subsp. holarctica FTNF002-00 5522537 YP_001427991.1 CDS FTA_0559 NC_009749.1 509744 510028 D endonuclease 509744..510028 Francisella tularensis subsp. holarctica FTNF002-00 5522539 YP_001427992.1 CDS FTA_0560 NC_009749.1 510266 513139 D type III restriction enzyme 510266..513139 Francisella tularensis subsp. holarctica FTNF002-00 5522540 YP_001427993.1 CDS ung NC_009749.1 513136 513798 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 513136..513798 Francisella tularensis subsp. holarctica FTNF002-00 5522541 YP_001427998.1 CDS gyrA NC_009749.1 515754 518360 D DNA gyrase subunit A 515754..518360 Francisella tularensis subsp. holarctica FTNF002-00 5523764 YP_001427999.1 CDS dxr NC_009749.1 518366 519523 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 518366..519523 Francisella tularensis subsp. holarctica FTNF002-00 5523765 YP_001428000.2 CDS FTA_0568 NC_009749.1 519529 521907 D outer membrane protein 519529..521907 Francisella tularensis subsp. holarctica FTNF002-00 5523766 YP_001428001.1 CDS FTA_0569 NC_009749.1 522043 522546 D outer membrane protein OmpH 522043..522546 Francisella tularensis subsp. holarctica FTNF002-00 5523767 YP_001428002.1 CDS lpxD NC_009749.1 522565 523578 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 522565..523578 Francisella tularensis subsp. holarctica FTNF002-00 5523768 YP_001428003.1 CDS fabZ NC_009749.1 523593 524084 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 523593..524084 Francisella tularensis subsp. holarctica FTNF002-00 5523769 YP_001428004.1 CDS lpxA NC_009749.1 524087 524866 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 524087..524866 Francisella tularensis subsp. holarctica FTNF002-00 5523770 YP_001428005.1 CDS lpxB NC_009749.1 524866 526008 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 524866..526008 Francisella tularensis subsp. holarctica FTNF002-00 5523771 YP_001428006.1 CDS FTA_0574 NC_009749.1 526067 526654 D hypothetical protein 526067..526654 Francisella tularensis subsp. holarctica FTNF002-00 5523772 YP_001428007.1 CDS FTA_0575 NC_009749.1 526745 527119 D hypothetical protein 526745..527119 Francisella tularensis subsp. holarctica FTNF002-00 5523773 YP_001428008.1 CDS FTA_0576 NC_009749.1 527526 528569 D glycosyl hydrolase family protein 527526..528569 Francisella tularensis subsp. holarctica FTNF002-00 5523774 YP_001428009.1 CDS FTA_0577 NC_009749.1 528940 529749 R hypothetical protein complement(528940..529749) Francisella tularensis subsp. holarctica FTNF002-00 5524222 YP_001428010.1 CDS FTA_0578 NC_009749.1 529819 530583 R phosphatidylcholine synthase complement(529819..530583) Francisella tularensis subsp. holarctica FTNF002-00 5523891 YP_001428011.2 CDS FTA_0579 NC_009749.1 530631 531512 R polyprenyl synthetase complement(530631..531512) Francisella tularensis subsp. holarctica FTNF002-00 5523892 YP_001428012.1 CDS FTA_0580 NC_009749.1 531509 532804 R 3-deoxy-D-manno-octulosonic-acid transferase complement(531509..532804) Francisella tularensis subsp. holarctica FTNF002-00 5523893 YP_001428013.1 CDS rdgB NC_009749.1 532909 533487 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase complement(532909..533487) Francisella tularensis subsp. holarctica FTNF002-00 5523894 YP_001428014.1 CDS proC NC_009749.1 533594 534418 D pyrroline-5-carboxylate reductase 533594..534418 Francisella tularensis subsp. holarctica FTNF002-00 5523895 YP_001428017.1 CDS FTA_0585 NC_009749.1 536176 536862 D two-component response regulator 536176..536862 Francisella tularensis subsp. holarctica FTNF002-00 5523898 YP_001428018.1 CDS lepB NC_009749.1 536867 537730 D signal peptidase I 536867..537730 Francisella tularensis subsp. holarctica FTNF002-00 5523899 YP_001428019.1 CDS rnc NC_009749.1 537737 538429 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 537737..538429 Francisella tularensis subsp. holarctica FTNF002-00 5523900 YP_001428020.1 CDS truB NC_009749.1 538416 539324 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 538416..539324 Francisella tularensis subsp. holarctica FTNF002-00 5523901 YP_001428021.1 CDS rnr NC_009749.1 539398 541569 D ribonuclease R 539398..541569 Francisella tularensis subsp. holarctica FTNF002-00 5523902 YP_001428022.1 CDS FTA_0590 NC_009749.1 541637 542329 R missing N-terminal residues comapred to Schu4 and WY96-3418; fatty acid desaturase complement(541637..542329) Francisella tularensis subsp. holarctica FTNF002-00 5523903 YP_001428023.1 CDS FTA_0591 NC_009749.1 542480 543223 R short chain dehydrogenase/reductase family oxidoreductase complement(542480..543223) Francisella tularensis subsp. holarctica FTNF002-00 5524537 YP_001428024.1 CDS FTA_0592 NC_009749.1 543225 543767 R hypothetical protein complement(543225..543767) Francisella tularensis subsp. holarctica FTNF002-00 5524538 YP_001428025.2 CDS FTA_0593 NC_009749.1 543764 544273 R hypothetical protein complement(543764..544273) Francisella tularensis subsp. holarctica FTNF002-00 5524539 YP_001428026.1 CDS FTA_0594 NC_009749.1 544266 545360 R missing N-terminal residues compared to WY96-3418 ORF; cyclopropane-fatty-acyl-phospholipid synthase complement(544266..545360) Francisella tularensis subsp. holarctica FTNF002-00 5524540 YP_001428029.1 CDS FTA_0597 NC_009749.1 546316 547371 R hypothetical protein complement(546316..547371) Francisella tularensis subsp. holarctica FTNF002-00 5524543 YP_001428034.1 CDS FTA_0602 NC_009749.1 549203 549823 R transposase ISFTu2 complement(549203..549823) Francisella tularensis subsp. holarctica FTNF002-00 5524548 YP_001428035.1 CDS FTA_0603 NC_009749.1 550137 550673 D hypothetical protein 550137..550673 Francisella tularensis subsp. holarctica FTNF002-00 5524549 YP_001428036.1 CDS FTA_0604 NC_009749.1 550791 551192 D hypothetical protein 550791..551192 Francisella tularensis subsp. holarctica FTNF002-00 5522655 YP_001428037.1 CDS FTA_0605 NC_009749.1 551367 551975 D hypothetical protein 551367..551975 Francisella tularensis subsp. holarctica FTNF002-00 5523675 YP_001428038.1 CDS FTA_0606 NC_009749.1 552032 553462 D hypothetical protein 552032..553462 Francisella tularensis subsp. holarctica FTNF002-00 5523676 YP_001428039.1 CDS FTA_0607 NC_009749.1 553473 554456 D hypothetical protein 553473..554456 Francisella tularensis subsp. holarctica FTNF002-00 5523677 YP_001428040.2 CDS FTA_0608 NC_009749.1 554462 555856 D hypothetical protein 554462..555856 Francisella tularensis subsp. holarctica FTNF002-00 5523678 YP_001428041.1 CDS FTA_0609 NC_009749.1 556069 556737 R N-terminal truncated comapred to Schu4; transposase ISFTu2 complement(556069..556737) Francisella tularensis subsp. holarctica FTNF002-00 5523679 YP_001428044.1 CDS FTA_0612 NC_009749.1 558171 559031 D catalyzes the formation of L-proline from L-ornithine; ornithine cyclodeaminase 558171..559031 Francisella tularensis subsp. holarctica FTNF002-00 5523682 YP_001428045.2 CDS FTA_0613 NC_009749.1 559102 560517 D putative nicotinate phosphoribosyltransferase 559102..560517 Francisella tularensis subsp. holarctica FTNF002-00 5523683 YP_001428046.1 CDS FTA_0614 NC_009749.1 560602 560829 D hypothetical protein 560602..560829 Francisella tularensis subsp. holarctica FTNF002-00 5523684 YP_001428047.2 CDS FTA_0616 NC_009749.1 560979 562259 D major facilitator transporter 560979..562259 Francisella tularensis subsp. holarctica FTNF002-00 5523685 YP_001428048.2 CDS FTA_0615 NC_009749.1 562252 562740 R thioesterase family protein complement(562252..562740) Francisella tularensis subsp. holarctica FTNF002-00 5523687 YP_001428049.1 CDS FTA_0617 NC_009749.1 562802 563989 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(562802..563989) Francisella tularensis subsp. holarctica FTNF002-00 5523686 YP_001428050.1 CDS FTA_0618 NC_009749.1 564002 566698 R fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein complement(564002..566698) Francisella tularensis subsp. holarctica FTNF002-00 5524550 YP_001428051.2 CDS fadE NC_009749.1 566771 569032 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(566771..569032) Francisella tularensis subsp. holarctica FTNF002-00 5524509 YP_001428052.1 CDS FTA_0620 NC_009749.1 569049 570737 R putative acyl Co-A synthetase/long chain fatty acid CoA ligase complement(569049..570737) Francisella tularensis subsp. holarctica FTNF002-00 5524510 YP_001428053.1 CDS FTA_0621 NC_009749.1 570953 571300 D ArsC family arsenate permease 570953..571300 Francisella tularensis subsp. holarctica FTNF002-00 5524511 YP_001428054.1 CDS FTA_0622 NC_009749.1 571349 573565 D isocitrate dehydrogenase 571349..573565 Francisella tularensis subsp. holarctica FTNF002-00 5524512 YP_001428055.1 CDS FTA_0623 NC_009749.1 573579 574466 D hypothetical protein 573579..574466 Francisella tularensis subsp. holarctica FTNF002-00 5524513 YP_001428056.1 CDS hrpA NC_009749.1 574486 578820 D ATP-dependent helicase 574486..578820 Francisella tularensis subsp. holarctica FTNF002-00 5524514 YP_001428057.1 CDS FTA_0625 NC_009749.1 579354 579974 D transposase ISFTu2 579354..579974 Francisella tularensis subsp. holarctica FTNF002-00 5524515 YP_001428058.2 CDS FTA_0626 NC_009749.1 580077 581813 D component of putative O antigen gene cluster; NAD dependent epimerase/dehydratase family protein 580077..581813 Francisella tularensis subsp. holarctica FTNF002-00 5524516 YP_001428059.1 CDS FTA_0627 NC_009749.1 581806 582438 D component of putative O antigen gene cluster; glycosyltransferase 581806..582438 Francisella tularensis subsp. holarctica FTNF002-00 5524517 YP_001428060.1 CDS wbtC NC_009749.1 582440 583231 D component of putative O antigen gen cluster; NAD-dependent epimerase/dehydratase family protein 582440..583231 Francisella tularensis subsp. holarctica FTNF002-00 5524518 YP_001428061.1 CDS wbtD NC_009749.1 583221 584312 D component of putative O antigen gene cluster; glycosyltransferase group I 583221..584312 Francisella tularensis subsp. holarctica FTNF002-00 5524519 YP_001428062.1 CDS wbtE NC_009749.1 584330 585640 D component of putative O antigen gene cluster; UDP-glucose/GDP-mannose dehydrogenase 584330..585640 Francisella tularensis subsp. holarctica FTNF002-00 5524520 YP_001428063.2 CDS wbtF NC_009749.1 585628 586611 D component of putative O antigen gene cluster; NAD dependent epimerase/dehydratase family protein 585628..586611 Francisella tularensis subsp. holarctica FTNF002-00 5524521 YP_001428064.1 CDS wzy NC_009749.1 586628 587857 D component of putative O antigen gene cluster; O-antigen polymerase 586628..587857 Francisella tularensis subsp. holarctica FTNF002-00 5524522 YP_001428065.2 CDS wbtG NC_009749.1 587854 588954 D component of putative O antigen gene cluster; glycosyltransferase group I 587854..588954 Francisella tularensis subsp. holarctica FTNF002-00 5522686 YP_001428066.1 CDS wbtH NC_009749.1 588954 590840 D component of putative antigen O gene complex; asparagine synthase 588954..590840 Francisella tularensis subsp. holarctica FTNF002-00 5522687 YP_001428067.1 CDS wbtI NC_009749.1 590833 591915 D component of putative O antigen gene complex; DegT/DnrJ/EryC1/StrS family sugar aminotransferase 590833..591915 Francisella tularensis subsp. holarctica FTNF002-00 5522688 YP_001428068.1 CDS wbtJ NC_009749.1 591912 592637 D component of putative O antigen gene complex; hypothetical protein 591912..592637 Francisella tularensis subsp. holarctica FTNF002-00 5522689 YP_001428069.1 CDS wzx NC_009749.1 592642 594129 D component of putative O antigen gene complex; O-antigen flippase 592642..594129 Francisella tularensis subsp. holarctica FTNF002-00 5522690 YP_001428070.2 CDS wbtK NC_009749.1 594122 594982 D component of putative O antigen gene complex; glycosyltransferase group 2 family protein 594122..594982 Francisella tularensis subsp. holarctica FTNF002-00 5522691 YP_001428071.1 CDS wbtL NC_009749.1 595007 595891 D component of putative O antigen gene complex; glucose-1-phosphate thymidylyltransferase 595007..595891 Francisella tularensis subsp. holarctica FTNF002-00 5522692 YP_001428072.2 CDS wbtM NC_009749.1 596438 597454 D component of putative O antigen gene complex; dTDP-glucose 4,6-dehydratase 596438..597454 Francisella tularensis subsp. holarctica FTNF002-00 5522693 YP_001428073.2 CDS FTA_0641 NC_009749.1 597599 598479 D programmed ribosomal frameshift; transposase ISFTu1 join(597599..597928,597928..598479) Francisella tularensis subsp. holarctica FTNF002-00 5522694 YP_001428075.1 CDS FTA_0643 NC_009749.1 598732 600138 D mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase 598732..600138 Francisella tularensis subsp. holarctica FTNF002-00 5522696 YP_001428076.1 CDS FTA_0644 NC_009749.1 600169 601653 D phosphoglucomutase/phosphomannomutase 600169..601653 Francisella tularensis subsp. holarctica FTNF002-00 5522697 YP_001428077.1 CDS rho NC_009749.1 602746 604008 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(602746..604008) Francisella tularensis subsp. holarctica FTNF002-00 5522698 YP_001428078.1 CDS trx1 NC_009749.1 604052 604375 R thioredoxin complement(604052..604375) Francisella tularensis subsp. holarctica FTNF002-00 5522699 YP_001428079.1 CDS FTA_0647 NC_009749.1 605428 606141 R transposase ISFTu2 complement(605428..606141) Francisella tularensis subsp. holarctica FTNF002-00 5522628 YP_001428080.1 CDS FTA_0648 NC_009749.1 606936 607838 D COG2256:MGS1,ATPase related to the helicase subunit of the Holliday junction resolvase; recombination factor protein RarA 606936..607838 Francisella tularensis subsp. holarctica FTNF002-00 5522629 YP_001428081.1 CDS rpoA2 NC_009749.1 607926 608879 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 607926..608879 Francisella tularensis subsp. holarctica FTNF002-00 5522630 YP_001428082.2 CDS FTA_0650 NC_009749.1 609498 609983 R ferritin-like protein complement(609498..609983) Francisella tularensis subsp. holarctica FTNF002-00 5524404 YP_001428085.1 CDS FTA_0653 NC_009749.1 611650 612417 D TatD family hydrolase 611650..612417 Francisella tularensis subsp. holarctica FTNF002-00 5522634 YP_001428087.1 CDS FTA_0655 NC_009749.1 613652 614311 R transposase ISFTu2 complement(613652..614311) Francisella tularensis subsp. holarctica FTNF002-00 5522636 YP_001428088.1 CDS FTA_0656 NC_009749.1 614602 615525 D ABC transporter ATP-binding protein 614602..615525 Francisella tularensis subsp. holarctica FTNF002-00 5522637 YP_001428089.2 CDS FTA_0657 NC_009749.1 615534 616313 D ABC transporter membrane protein 615534..616313 Francisella tularensis subsp. holarctica FTNF002-00 5522638 YP_001428090.1 CDS FTA_0658 NC_009749.1 616317 617261 R glycosyl transferase family protein complement(616317..617261) Francisella tularensis subsp. holarctica FTNF002-00 5522639 YP_001428091.1 CDS FTA_0659 NC_009749.1 617452 618342 D NAD(+)/NADH kinase 617452..618342 Francisella tularensis subsp. holarctica FTNF002-00 5522640 YP_001428092.2 CDS FTA_0660 NC_009749.1 618349 618975 R amino acid transporter complement(618349..618975) Francisella tularensis subsp. holarctica FTNF002-00 5523688 YP_001428093.1 CDS trmB NC_009749.1 619045 619734 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 619045..619734 Francisella tularensis subsp. holarctica FTNF002-00 5524262 YP_001428094.1 CDS FTA_0662 NC_009749.1 619744 620460 D hypothetical protein 619744..620460 Francisella tularensis subsp. holarctica FTNF002-00 5524263 YP_001428096.2 CDS FTA_0664 NC_009749.1 621043 621923 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(621043..621594,621594..621923)) Francisella tularensis subsp. holarctica FTNF002-00 5524265 YP_001428098.2 CDS FTA_0666 NC_009749.1 622073 622396 D ArsR family transcriptional regulator 622073..622396 Francisella tularensis subsp. holarctica FTNF002-00 5524267 YP_001428103.1 CDS FTA_0671 NC_009749.1 624742 625428 D metallo-beta-lactamase family protein 624742..625428 Francisella tularensis subsp. holarctica FTNF002-00 5524272 YP_001428104.1 CDS FTA_0673 NC_009749.1 625430 626179 D hypothetical protein 625430..626179 Francisella tularensis subsp. holarctica FTNF002-00 5524273 YP_001428105.1 CDS FTA_0672 NC_009749.1 626172 626780 R oxidoreductase, 2-oxoglutarate (2OG) and Fe(II)-dependent complement(626172..626780) Francisella tularensis subsp. holarctica FTNF002-00 5524275 YP_001428106.1 CDS FTA_0674 NC_009749.1 626832 627281 R hypothetical protein complement(626832..627281) Francisella tularensis subsp. holarctica FTNF002-00 5524274 YP_001428107.1 CDS FTA_0675 NC_009749.1 627512 628012 R hypothetical protein complement(627512..628012) Francisella tularensis subsp. holarctica FTNF002-00 5522713 YP_001428108.2 CDS FTA_0676 NC_009749.1 628029 628526 R hypothetical protein complement(628029..628526) Francisella tularensis subsp. holarctica FTNF002-00 5522714 YP_001428109.1 CDS nusB NC_009749.1 628606 629031 D transcription antitermination factor 628606..629031 Francisella tularensis subsp. holarctica FTNF002-00 5522715 YP_001428110.2 CDS FTA_0677 NC_009749.1 629015 629800 R carbon-nitrogen family hydrolase complement(629015..629800) Francisella tularensis subsp. holarctica FTNF002-00 5522717 YP_001428111.1 CDS FTA_0679 NC_009749.1 629954 630367 D lipoprotein 629954..630367 Francisella tularensis subsp. holarctica FTNF002-00 5522716 YP_001428112.1 CDS FTA_0680 NC_009749.1 630513 631322 R C-terminal truncation compred to Schu4 and WY96-3418; hypothetical protein complement(630513..631322) Francisella tularensis subsp. holarctica FTNF002-00 5522718 YP_001428113.1 CDS FTA_0681 NC_009749.1 631430 631912 R hypothetical protein complement(631430..631912) Francisella tularensis subsp. holarctica FTNF002-00 5522719 YP_001428116.1 CDS proS NC_009749.1 633190 634887 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(633190..634887) Francisella tularensis subsp. holarctica FTNF002-00 5522722 YP_001428117.1 CDS FTA_0685 NC_009749.1 635493 635690 R hypothetical protein complement(635493..635690) Francisella tularensis subsp. holarctica FTNF002-00 5522723 YP_001428118.2 CDS FTA_0686 NC_009749.1 635741 636250 R hypothetical protein complement(635741..636250) Francisella tularensis subsp. holarctica FTNF002-00 5522724 YP_001428119.1 CDS FTA_0687 NC_009749.1 636987 637121 D hypothetical protein 636987..637121 Francisella tularensis subsp. holarctica FTNF002-00 5522725 YP_001428120.1 CDS FTA_0688 NC_009749.1 637456 637992 R hypothetical protein complement(637456..637992) Francisella tularensis subsp. holarctica FTNF002-00 5522726 YP_001715624.1 CDS FTA_2147 NC_009749.1 638070 638189 D hypothetical protein 638070..638189 Francisella tularensis subsp. holarctica FTNF002-00 5983829 YP_001428121.1 CDS sufE NC_009749.1 638699 639115 D Fe-S cluster assembly related protein 638699..639115 Francisella tularensis subsp. holarctica FTNF002-00 5524658 YP_001428122.1 CDS FTA_0690 NC_009749.1 639116 639865 D putative uroporphyrinogen III synthase 639116..639865 Francisella tularensis subsp. holarctica FTNF002-00 5523647 YP_001428123.1 CDS FTA_0691 NC_009749.1 639831 640916 D hypothetical protein 639831..640916 Francisella tularensis subsp. holarctica FTNF002-00 5523648 YP_001428124.1 CDS FTA_0692 NC_009749.1 640913 642070 D hypothetical protein 640913..642070 Francisella tularensis subsp. holarctica FTNF002-00 5523649 YP_001428125.1 CDS FTA_0693 NC_009749.1 642084 642842 D hydroxyacylglutathione hydrolase 642084..642842 Francisella tularensis subsp. holarctica FTNF002-00 5523650 YP_001428126.1 CDS FTA_0694 NC_009749.1 642920 643627 R putative cell division protein complement(642920..643627) Francisella tularensis subsp. holarctica FTNF002-00 5523651 YP_001428127.1 CDS FTA_0695 NC_009749.1 643820 643960 D hypothetical protein 643820..643960 Francisella tularensis subsp. holarctica FTNF002-00 5523652 YP_001428128.1 CDS FTA_0696 NC_009749.1 643977 645611 D hypothetical protein 643977..645611 Francisella tularensis subsp. holarctica FTNF002-00 5523653 YP_001428129.1 CDS FTA_0697 NC_009749.1 646183 646836 R peptidase S24-like domain-containing protein complement(646183..646836) Francisella tularensis subsp. holarctica FTNF002-00 5524405 YP_001428130.1 CDS FTA_0698 NC_009749.1 647005 647373 D hypothetical protein 647005..647373 Francisella tularensis subsp. holarctica FTNF002-00 5523655 YP_001428131.1 CDS FTA_0699 NC_009749.1 647404 648276 R integral membrane protein complement(647404..648276) Francisella tularensis subsp. holarctica FTNF002-00 5523656 YP_001428132.1 CDS FTA_0700 NC_009749.1 648453 650039 D putative glutamate synthase 648453..650039 Francisella tularensis subsp. holarctica FTNF002-00 5523657 YP_001428133.1 CDS recC NC_009749.1 650116 653355 D exodeoxyribonuclease V subunit gamma 650116..653355 Francisella tularensis subsp. holarctica FTNF002-00 5523658 YP_001428134.1 CDS FTA_0702 NC_009749.1 653339 653869 D hypothetical protein 653339..653869 Francisella tularensis subsp. holarctica FTNF002-00 5523659 YP_001428135.1 CDS FTA_0703 NC_009749.1 654012 655442 D ATP-binding transcriptional regulator 654012..655442 Francisella tularensis subsp. holarctica FTNF002-00 5524225 YP_001428136.1 CDS recB NC_009749.1 655514 659167 D exodeoxyribonuclease V subunit beta 655514..659167 Francisella tularensis subsp. holarctica FTNF002-00 5524226 YP_001428137.1 CDS recD NC_009749.1 659160 661001 D exodeoxyribonuclease V subunit alpha 659160..661001 Francisella tularensis subsp. holarctica FTNF002-00 5524227 YP_001428138.1 CDS FTA_0706 NC_009749.1 661010 661780 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(661010..661780) Francisella tularensis subsp. holarctica FTNF002-00 5524228 YP_001428139.1 CDS panD NC_009749.1 661784 662119 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(661784..662119) Francisella tularensis subsp. holarctica FTNF002-00 5524229 YP_001428140.1 CDS panC NC_009749.1 662113 662898 R pantoate--beta-alanine ligase complement(662113..662898) Francisella tularensis subsp. holarctica FTNF002-00 5524230 YP_001428141.1 CDS panB NC_009749.1 662885 663682 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(662885..663682) Francisella tularensis subsp. holarctica FTNF002-00 5524231 YP_001428142.1 CDS FTA_0710 NC_009749.1 663684 664343 R hypothetical protein complement(663684..664343) Francisella tularensis subsp. holarctica FTNF002-00 5524232 YP_001428143.1 CDS ligA NC_009749.1 664705 666741 D DNA ligase 664705..666741 Francisella tularensis subsp. holarctica FTNF002-00 5524233 YP_001428144.1 CDS FTA_0713 NC_009749.1 666738 667115 D hypothetical protein 666738..667115 Francisella tularensis subsp. holarctica FTNF002-00 5524234 YP_001428145.2 CDS FTA_0712 NC_009749.1 667093 667973 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(667093..667644,667644..667973)) Francisella tularensis subsp. holarctica FTNF002-00 5524236 YP_001428147.1 CDS FTA_0715 NC_009749.1 668197 669003 R ABC transporter permease complement(668197..669003) Francisella tularensis subsp. holarctica FTNF002-00 5524237 YP_001428148.1 CDS FTA_0716 NC_009749.1 669017 669898 R polyamine ABC transporter permease complement(669017..669898) Francisella tularensis subsp. holarctica FTNF002-00 5524238 YP_001428149.1 CDS FTA_0717 NC_009749.1 669898 671019 R polyamine ABC transporter ATP-binding protein complement(669898..671019) Francisella tularensis subsp. holarctica FTNF002-00 5523588 YP_001428150.1 CDS FTA_0718 NC_009749.1 671164 671301 D hypothetical protein 671164..671301 Francisella tularensis subsp. holarctica FTNF002-00 5523589 YP_001428151.2 CDS FTA_0719 NC_009749.1 671302 672182 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(671302..671853,671853..672182)) Francisella tularensis subsp. holarctica FTNF002-00 5523590 YP_001428153.1 CDS FTA_0721 NC_009749.1 672277 672420 D quinone-oxidoreductase QR2 672277..672420 Francisella tularensis subsp. holarctica FTNF002-00 5523592 YP_001428155.1 CDS FTA_0723 NC_009749.1 672952 673374 R hypothetical protein complement(672952..673374) Francisella tularensis subsp. holarctica FTNF002-00 5523594 YP_001428156.1 CDS nadE NC_009749.1 673478 674227 R NAD+ synthetase complement(673478..674227) Francisella tularensis subsp. holarctica FTNF002-00 5523595 YP_001428157.1 CDS FTA_0725 NC_009749.1 674356 675828 R outer membrane efflux protein complement(674356..675828) Francisella tularensis subsp. holarctica FTNF002-00 5523596 YP_001428158.1 CDS FTA_0726 NC_009749.1 675838 676860 R HlyD family secretion protein complement(675838..676860) Francisella tularensis subsp. holarctica FTNF002-00 5523597 YP_001428159.1 CDS FTA_0727 NC_009749.1 676882 678411 R drug:H+ antiporter-1 (DHA2) family protein complement(676882..678411) Francisella tularensis subsp. holarctica FTNF002-00 5523598 YP_001428160.1 CDS FTA_0729 NC_009749.1 678576 679403 D AraC family transcriptional regulator 678576..679403 Francisella tularensis subsp. holarctica FTNF002-00 5523599 YP_001428161.1 CDS FTA_0728 NC_009749.1 679391 681082 R PRK08974, PRK08974:long-chain-fatty-acid--CoA ligase.(e-value:2e-128); long-chain-fatty-acid--CoA ligase complement(679391..681082) Francisella tularensis subsp. holarctica FTNF002-00 5523601 YP_001428162.1 CDS FTA_0730 NC_009749.1 681190 682677 R amino acid/peptide transporter complement(681190..682677) Francisella tularensis subsp. holarctica FTNF002-00 5523600 YP_001428163.2 CDS FTA_0731 NC_009749.1 682907 683635 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(682907..683635) Francisella tularensis subsp. holarctica FTNF002-00 5524015 YP_001428164.1 CDS FTA_0733 NC_009749.1 683706 684392 D hypothetical protein 683706..684392 Francisella tularensis subsp. holarctica FTNF002-00 5524016 YP_001428165.1 CDS FTA_0732 NC_009749.1 684382 685080 R hypothetical protein complement(684382..685080) Francisella tularensis subsp. holarctica FTNF002-00 5524018 YP_001428166.2 CDS FTA_0734 NC_009749.1 685085 685810 R hypothetical protein complement(685085..685810) Francisella tularensis subsp. holarctica FTNF002-00 5524017 YP_001428167.1 CDS FTA_0735 NC_009749.1 685820 686581 R ABC transporter ATP-binding protein complement(685820..686581) Francisella tularensis subsp. holarctica FTNF002-00 5524019 YP_001428168.1 CDS FTA_0736 NC_009749.1 686596 687696 R ABC transporter membrane protein complement(686596..687696) Francisella tularensis subsp. holarctica FTNF002-00 5524020 YP_001428169.1 CDS FTA_0737 NC_009749.1 687771 688568 R hypothetical protein complement(687771..688568) Francisella tularensis subsp. holarctica FTNF002-00 5524021 YP_001428170.2 CDS FTA_0738 NC_009749.1 688561 689559 R RNA pseudouridine synthase, RluA family protein complement(688561..689559) Francisella tularensis subsp. holarctica FTNF002-00 5524022 YP_001428171.2 CDS FTA_0739 NC_009749.1 689647 690471 D lipoprotein 689647..690471 Francisella tularensis subsp. holarctica FTNF002-00 5524023 YP_001428174.1 CDS FTA_0742 NC_009749.1 692418 693875 R hypothetical protein complement(692418..693875) Francisella tularensis subsp. holarctica FTNF002-00 5524026 YP_001428175.1 CDS glyA NC_009749.1 694153 695406 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(694153..695406) Francisella tularensis subsp. holarctica FTNF002-00 5524027 YP_001428176.1 CDS FTA_0744 NC_009749.1 695510 696058 D hypothetical protein 695510..696058 Francisella tularensis subsp. holarctica FTNF002-00 5524028 YP_001428177.1 CDS FTA_0745 NC_009749.1 696073 697344 R hypothetical protein complement(696073..697344) Francisella tularensis subsp. holarctica FTNF002-00 5523345 YP_001428178.1 CDS FTA_0746 NC_009749.1 697552 698883 D hypothetical protein 697552..698883 Francisella tularensis subsp. holarctica FTNF002-00 5523346 YP_001428179.1 CDS FTA_0747 NC_009749.1 698909 699799 R glycosyl transferase family protein complement(698909..699799) Francisella tularensis subsp. holarctica FTNF002-00 5523347 YP_001428180.1 CDS FTA_0748 NC_009749.1 699807 700895 R hypothetical protein complement(699807..700895) Francisella tularensis subsp. holarctica FTNF002-00 5523348 YP_001428181.1 CDS FTA_0749 NC_009749.1 701065 702129 D group 1 family glycosyltransferase 701065..702129 Francisella tularensis subsp. holarctica FTNF002-00 5523349 YP_001428182.1 CDS FTA_0750 NC_009749.1 702206 703159 R linear amide C-N hydrolase complement(702206..703159) Francisella tularensis subsp. holarctica FTNF002-00 5523350 YP_001428185.1 CDS FTA_0753 NC_009749.1 704856 706052 R tRNA(Ile)-lysidine synthase complement(704856..706052) Francisella tularensis subsp. holarctica FTNF002-00 5523353 YP_001428186.1 CDS FTA_0754 NC_009749.1 706053 707288 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(706053..707288) Francisella tularensis subsp. holarctica FTNF002-00 5523354 YP_001428187.1 CDS thyA NC_009749.1 707300 708124 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(707300..708124) Francisella tularensis subsp. holarctica FTNF002-00 5523355 YP_001428188.1 CDS lgt NC_009749.1 708109 708915 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(708109..708915) Francisella tularensis subsp. holarctica FTNF002-00 5523356 YP_001428189.1 CDS FTA_0757 NC_009749.1 708930 711461 R deletion comapred to Schu4 and WY96-3418 ORFs; ribonuclease complement(708930..711461) Francisella tularensis subsp. holarctica FTNF002-00 5523357 YP_001428190.1 CDS FTA_0758 NC_009749.1 711711 712886 D cysteine desulfarase 711711..712886 Francisella tularensis subsp. holarctica FTNF002-00 5523358 YP_001428191.1 CDS FTA_0759 NC_009749.1 712879 713208 D hypothetical protein 712879..713208 Francisella tularensis subsp. holarctica FTNF002-00 5523375 YP_001428192.2 CDS FTA_0760 NC_009749.1 713192 713890 D putative DNA repair protein 713192..713890 Francisella tularensis subsp. holarctica FTNF002-00 5523376 YP_001428193.1 CDS FTA_0761 NC_009749.1 713966 714613 R hypothetical protein complement(713966..714613) Francisella tularensis subsp. holarctica FTNF002-00 5523377 YP_001428194.1 CDS FTA_0762 NC_009749.1 714669 715295 R hypothetical protein complement(714669..715295) Francisella tularensis subsp. holarctica FTNF002-00 5523378 YP_001428195.1 CDS FTA_0763 NC_009749.1 715302 715568 R hypothetical protein complement(715302..715568) Francisella tularensis subsp. holarctica FTNF002-00 5523379 YP_001428196.1 CDS FTA_0764 NC_009749.1 715571 716119 R 5,10-methenyltetrahydrofolate synthetase complement(715571..716119) Francisella tularensis subsp. holarctica FTNF002-00 5523380 YP_001428197.1 CDS FTA_0765 NC_009749.1 716559 717095 D hypothetical protein 716559..717095 Francisella tularensis subsp. holarctica FTNF002-00 5523381 YP_001428198.1 CDS FTA_0766 NC_009749.1 717104 718315 D 2-octaprenyl-6-methoxyphenyl hydroxylase 717104..718315 Francisella tularensis subsp. holarctica FTNF002-00 5523382 YP_001428199.1 CDS FTA_0767 NC_009749.1 718305 719540 D ubiquinone biosynthesis hydroxylase/FAD-dependent monooxygenase 718305..719540 Francisella tularensis subsp. holarctica FTNF002-00 5523383 YP_001428200.1 CDS FTA_0768 NC_009749.1 719562 720023 D hypothetical protein 719562..720023 Francisella tularensis subsp. holarctica FTNF002-00 5523384 YP_001428201.1 CDS queA NC_009749.1 720049 721065 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 720049..721065 Francisella tularensis subsp. holarctica FTNF002-00 5523385 YP_001428202.1 CDS FTA_0770 NC_009749.1 721700 722491 D HAD family hydrolase 721700..722491 Francisella tularensis subsp. holarctica FTNF002-00 5523386 YP_001428203.1 CDS FTA_0771 NC_009749.1 722745 723458 R hypothetical protein complement(722745..723458) Francisella tularensis subsp. holarctica FTNF002-00 5523387 YP_001428204.1 CDS gloA NC_009749.1 723574 723957 D lactoylglutathione lyase 723574..723957 Francisella tularensis subsp. holarctica FTNF002-00 5523388 YP_001428205.2 CDS FTA_0773 NC_009749.1 724411 725291 D programmed ribosomal frameshift; transposase ISFTu1 join(724411..724740,724740..725291) Francisella tularensis subsp. holarctica FTNF002-00 5523719 YP_001428209.1 CDS rpiA NC_009749.1 727221 727895 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(727221..727895) Francisella tularensis subsp. holarctica FTNF002-00 5523723 YP_001428210.1 CDS FTA_0778 NC_009749.1 727897 729267 R hypothetical protein complement(727897..729267) Francisella tularensis subsp. holarctica FTNF002-00 5523724 YP_001428211.1 CDS FTA_0779 NC_009749.1 729281 729673 R hypothetical protein complement(729281..729673) Francisella tularensis subsp. holarctica FTNF002-00 5523725 YP_001428212.1 CDS gidA NC_009749.1 729685 731568 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(729685..731568) Francisella tularensis subsp. holarctica FTNF002-00 5523726 YP_001428213.1 CDS FTA_0781 NC_009749.1 731711 732793 D hypothetical protein 731711..732793 Francisella tularensis subsp. holarctica FTNF002-00 5523727 YP_001428214.1 CDS FTA_0782 NC_009749.1 732780 733685 D hypothetical protein 732780..733685 Francisella tularensis subsp. holarctica FTNF002-00 5523728 YP_001428217.1 CDS FTA_0785 NC_009749.1 734641 735363 D short chain dehydrogenase/reductase family oxidoreductase 734641..735363 Francisella tularensis subsp. holarctica FTNF002-00 5523731 YP_001428218.1 CDS FTA_0786 NC_009749.1 735497 736945 D exonuclease 735497..736945 Francisella tularensis subsp. holarctica FTNF002-00 5523732 YP_001428219.1 CDS uvrB NC_009749.1 736947 738953 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 736947..738953 Francisella tularensis subsp. holarctica FTNF002-00 5523959 YP_001428220.1 CDS FTA_0788 NC_009749.1 738957 739787 D hypothetical protein 738957..739787 Francisella tularensis subsp. holarctica FTNF002-00 5523960 YP_001428221.1 CDS murI NC_009749.1 739787 740584 D glutamate racemase 739787..740584 Francisella tularensis subsp. holarctica FTNF002-00 5523961 YP_001428222.1 CDS FTA_0790 NC_009749.1 740675 741952 D major facilitator transporter 740675..741952 Francisella tularensis subsp. holarctica FTNF002-00 5523962 YP_001428223.1 CDS FTA_0791 NC_009749.1 742206 742856 D transposase ISFTu2 742206..742856 Francisella tularensis subsp. holarctica FTNF002-00 5523963 YP_001428224.1 CDS FTA_0792 NC_009749.1 742970 744337 D hypothetical protein 742970..744337 Francisella tularensis subsp. holarctica FTNF002-00 5523964 YP_001428225.1 CDS FTA_0793 NC_009749.1 744484 745410 D hypothetical protein 744484..745410 Francisella tularensis subsp. holarctica FTNF002-00 5523965 YP_001428226.1 CDS FTA_0794 NC_009749.1 745427 747178 D transglutaminase-like superfamily protein 745427..747178 Francisella tularensis subsp. holarctica FTNF002-00 5523966 YP_001428229.1 CDS xseA NC_009749.1 748541 749926 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 748541..749926 Francisella tularensis subsp. holarctica FTNF002-00 5523969 YP_001428230.1 CDS FTA_0798 NC_009749.1 749910 750110 D hypothetical protein 749910..750110 Francisella tularensis subsp. holarctica FTNF002-00 5523970 YP_001428234.1 CDS FTA_0802 NC_009749.1 751723 752334 R hypothetical protein complement(751723..752334) Francisella tularensis subsp. holarctica FTNF002-00 5524060 YP_001428235.1 CDS FTA_0803 NC_009749.1 752601 753356 R ATPase complement(752601..753356) Francisella tularensis subsp. holarctica FTNF002-00 5524061 YP_001428236.1 CDS smpB NC_009749.1 753357 753830 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(753357..753830) Francisella tularensis subsp. holarctica FTNF002-00 5524062 YP_001428237.1 CDS FTA_0805 NC_009749.1 753905 754336 D hypothetical protein 753905..754336 Francisella tularensis subsp. holarctica FTNF002-00 5524063 YP_001428238.1 CDS FTA_0806 NC_009749.1 754336 754641 D hypothetical protein 754336..754641 Francisella tularensis subsp. holarctica FTNF002-00 5524064 YP_001428239.1 CDS FTA_0807 NC_009749.1 754683 755888 D FAD dependent oxidoreductase 754683..755888 Francisella tularensis subsp. holarctica FTNF002-00 5524065 YP_001428240.2 CDS FTA_0808 NC_009749.1 755965 756885 D putative VacJ-like lipoprotein 755965..756885 Francisella tularensis subsp. holarctica FTNF002-00 5524066 YP_001428241.2 CDS ggt NC_009749.1 756940 758745 D gamma-glutamyltransferase 756940..758745 Francisella tularensis subsp. holarctica FTNF002-00 5524067 YP_001428242.1 CDS FTA_0810 NC_009749.1 758761 759516 R hypothetical protein complement(758761..759516) Francisella tularensis subsp. holarctica FTNF002-00 5524068 YP_001428243.1 CDS typA NC_009749.1 759688 761505 R GTP binding translational elongation factor Tu and G family protein complement(759688..761505) Francisella tularensis subsp. holarctica FTNF002-00 5524069 YP_001428244.1 CDS FTA_0812 NC_009749.1 761995 763479 D hypothetical protein 761995..763479 Francisella tularensis subsp. holarctica FTNF002-00 5524070 YP_001428251.1 CDS FTA_0819 NC_009749.1 765958 766728 D hypothetical protein 765958..766728 Francisella tularensis subsp. holarctica FTNF002-00 5523452 YP_001428252.1 CDS FTA_0820 NC_009749.1 766819 767007 D hypothetical protein 766819..767007 Francisella tularensis subsp. holarctica FTNF002-00 5523453 YP_001428255.1 CDS FTA_0823 NC_009749.1 768519 768950 D cold shock DNA-binding domain-containing protein 768519..768950 Francisella tularensis subsp. holarctica FTNF002-00 5523456 YP_001428258.2 CDS FTA_0825 NC_009749.1 770239 771119 R programmed ribosomal frameshift; transposase ISFTu1 complement(join(770239..770790,770790..771119)) Francisella tularensis subsp. holarctica FTNF002-00 5523460 YP_001428261.1 CDS FTA_0828 NC_009749.1 771348 773096 R hypothetical protein complement(771348..773096) Francisella tularensis subsp. holarctica FTNF002-00 5524552 YP_001428262.2 CDS FTA_0830 NC_009749.1 773163 774035 R GTP-binding protein complement(773163..774035) Francisella tularensis subsp. holarctica FTNF002-00 5524551 YP_001428263.1 CDS nagA NC_009749.1 774098 775231 D N-acetylglucosamine-6-phosphate deacetylase 774098..775231 Francisella tularensis subsp. holarctica FTNF002-00 5524553 YP_001428264.2 CDS FTA_0832 NC_009749.1 775235 775873 D glycoprotease family protein 775235..775873 Francisella tularensis subsp. holarctica FTNF002-00 5524554 YP_001428265.2 CDS FTA_0833 NC_009749.1 775877 776683 D glutamine amidotransferases class-II family protein 775877..776683 Francisella tularensis subsp. holarctica FTNF002-00 5524555 YP_001428266.1 CDS FTA_0834 NC_009749.1 776693 777886 D aspartate aminotransferase 776693..777886 Francisella tularensis subsp. holarctica FTNF002-00 5524556 YP_001428267.1 CDS era NC_009749.1 778000 778893 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 778000..778893 Francisella tularensis subsp. holarctica FTNF002-00 5524557 YP_001428268.1 CDS FTA_0836 NC_009749.1 779060 779323 D N-terminal truncation compared to Schu4 and WY96-3418 ORFs; hypothetical protein 779060..779323 Francisella tularensis subsp. holarctica FTNF002-00 5524558 YP_001428272.1 CDS adk NC_009749.1 782663 783319 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(782663..783319) Francisella tularensis subsp. holarctica FTNF002-00 5524562 YP_001428273.1 CDS FTA_0841 NC_009749.1 783446 784450 D hypothetical protein 783446..784450 Francisella tularensis subsp. holarctica FTNF002-00 5524563 YP_001428274.1 CDS FTA_0842 NC_009749.1 784452 785015 D Type IV pili associated protein 784452..785015 Francisella tularensis subsp. holarctica FTNF002-00 5524564 YP_001428275.2 CDS FTA_0843 NC_009749.1 785009 785605 D type IV pili associated protein 785009..785605 Francisella tularensis subsp. holarctica FTNF002-00 5523932 YP_001428276.1 CDS FTA_0844 NC_009749.1 785611 786201 D pilus assembly protein 785611..786201 Francisella tularensis subsp. holarctica FTNF002-00 5523933 YP_001428277.1 CDS FTA_0845 NC_009749.1 786214 787986 D type IV pilus secretin 786214..787986 Francisella tularensis subsp. holarctica FTNF002-00 5523934 YP_001428278.1 CDS aroK NC_009749.1 788112 788642 D type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 788112..788642 Francisella tularensis subsp. holarctica FTNF002-00 5523935 YP_001428279.1 CDS aroB NC_009749.1 788639 789718 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 788639..789718 Francisella tularensis subsp. holarctica FTNF002-00 5523936 YP_001428280.1 CDS FTA_0848 NC_009749.1 789776 789901 D hypothetical protein 789776..789901 Francisella tularensis subsp. holarctica FTNF002-00 5523937 YP_001428281.1 CDS FTA_0849 NC_009749.1 790067 790450 R hypothetical protein complement(790067..790450) Francisella tularensis subsp. holarctica FTNF002-00 5523938 YP_001428282.1 CDS FTA_0850 NC_009749.1 790664 790951 D hypothetical protein 790664..790951 Francisella tularensis subsp. holarctica FTNF002-00 5523939 YP_001428283.1 CDS putA NC_009749.1 790968 795032 D proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 790968..795032 Francisella tularensis subsp. holarctica FTNF002-00 5523940 YP_001428284.2 CDS FTA_0852 NC_009749.1 795192 796700 D amino acid transporter 795192..796700 Francisella tularensis subsp. holarctica FTNF002-00 5523941 YP_001428285.1 CDS FTA_0853 NC_009749.1 796776 797960 D major facilitator transporter 796776..797960 Francisella tularensis subsp. holarctica FTNF002-00 5523942 YP_001428286.1 CDS coaBC NC_009749.1 797973 799148 D bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase 797973..799148 Francisella tularensis subsp. holarctica FTNF002-00 5523943 YP_001428289.1 CDS FTA_0857 NC_009749.1 800232 800462 R cation transport regulator complement(800232..800462) Francisella tularensis subsp. holarctica FTNF002-00 5523733 YP_001428293.1 CDS FTA_0861 NC_009749.1 801521 801724 R N-terminal truncated comapred to Schu4 and WY96-3418 ORFs; hypothetical protein complement(801521..801724) Francisella tularensis subsp. holarctica FTNF002-00 5523737 YP_001428294.1 CDS FTA_0862 NC_009749.1 801836 802261 R PRC-barrel domain-containing protein complement(801836..802261) Francisella tularensis subsp. holarctica FTNF002-00 5523738 YP_001428295.1 CDS FTA_0863 NC_009749.1 802460 802675 R PRC-barrel domain-containing protein complement(802460..802675) Francisella tularensis subsp. holarctica FTNF002-00 5523739 YP_001428296.1 CDS FTA_0864 NC_009749.1 802730 802927 R hypothetical protein complement(802730..802927) Francisella tularensis subsp. holarctica FTNF002-00 5523740 YP_001428297.1 CDS FTA_0865 NC_009749.1 803546 803668 D hypothetical protein 803546..803668 Francisella tularensis subsp. holarctica FTNF002-00 5523741 YP_001715625.1 CDS FTA_2149 NC_009749.1 805865 806014 R hypothetical protein complement(805865..806014) Francisella tularensis subsp. holarctica FTNF002-00 5983831 YP_001428302.1 CDS hemH NC_009749.1 805999 806997 R protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase complement(805999..806997) Francisella tularensis subsp. holarctica FTNF002-00 5523746 YP_001428303.1 CDS FTA_0871 NC_009749.1 807131 807391 D hypothetical protein 807131..807391 Francisella tularensis subsp. holarctica FTNF002-00 5523420 YP_001428304.1 CDS FTA_0872 NC_009749.1 807351 807743 D hypothetical protein 807351..807743 Francisella tularensis subsp. holarctica FTNF002-00 5523421 YP_001428308.1 CDS FTA_0876 NC_009749.1 808989 810218 R Type IV pili polytopic inner membrane protein complement(808989..810218) Francisella tularensis subsp. holarctica FTNF002-00 5523425 YP_001428309.1 CDS pilB NC_009749.1 810233 812014 R type II secretion system protein/type IV-A pilus assembly ATPase PilB complement(810233..812014) Francisella tularensis subsp. holarctica FTNF002-00 5523426 YP_001428310.1 CDS FTA_0879 NC_009749.1 812172 812924 D glycerophosphoryl diester phosphodiesterase 812172..812924 Francisella tularensis subsp. holarctica FTNF002-00 5523427 YP_001428311.1 CDS FTA_0878 NC_009749.1 812913 813656 R molybdopterin binding domain-containing protein complement(812913..813656) Francisella tularensis subsp. holarctica FTNF002-00 5523429 YP_001428312.1 CDS FTA_0880 NC_009749.1 813780 816602 D catalyze the formation of cyanophycin which may act to store excess nitrogen; cyanophycin synthetase 813780..816602 Francisella tularensis subsp. holarctica FTNF002-00 5523428 YP_001428313.1 CDS FTA_0881 NC_009749.1 816628 818313 D UDP-N-acetylmuramyl tripeptide synthase 816628..818313 Francisella tularensis subsp. holarctica FTNF002-00 5523430 YP_001428314.1 CDS ispF NC_009749.1 818318 818797 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(818318..818797) Francisella tularensis subsp. holarctica FTNF002-00 5523431 YP_001428315.1 CDS FTA_0883 NC_009749.1 818810 819568 R rhodanese-like domain-containing protein complement(818810..819568) Francisella tularensis subsp. holarctica FTNF002-00 5523432 YP_001428319.1 CDS FTA_0887 NC_009749.1 820825 822297 R ABC transporter permease complement(820825..822297) Francisella tularensis subsp. holarctica FTNF002-00 5523790 YP_001428320.1 CDS FTA_0888 NC_009749.1 822275 823327 R ABC transporter ATP-binding protein complement(822275..823327) Francisella tularensis subsp. holarctica FTNF002-00 5523791 YP_001428321.1 CDS FTA_0889 NC_009749.1 823314 823928 R hypothetical protein complement(823314..823928) Francisella tularensis subsp. holarctica FTNF002-00 5523792 YP_001428324.1 CDS FTA_0892 NC_009749.1 825783 826004 R hypothetical protein complement(825783..826004) Francisella tularensis subsp. holarctica FTNF002-00 5523795 YP_001428325.1 CDS tgt NC_009749.1 826310 827413 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 826310..827413 Francisella tularensis subsp. holarctica FTNF002-00 5523796 YP_001428328.2 CDS FTA_0896 NC_009749.1 828401 829216 D integral membrane protein 828401..829216 Francisella tularensis subsp. holarctica FTNF002-00 5523799 YP_001428329.1 CDS FTA_0897 NC_009749.1 829288 829860 D isochorismatase hydrolase family protein 829288..829860 Francisella tularensis subsp. holarctica FTNF002-00 5523800 YP_001428330.1 CDS FTA_0898 NC_009749.1 829979 830152 D hypothetical protein 829979..830152 Francisella tularensis subsp. holarctica FTNF002-00 5523801 YP_001428331.2 CDS yajC NC_009749.1 830415 830771 D preprotein translocase subunit YajC 830415..830771 Francisella tularensis subsp. holarctica FTNF002-00 5523273 YP_001428332.2 CDS secD NC_009749.1 830828 832765 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 830828..832765 Francisella tularensis subsp. holarctica FTNF002-00 5523274 YP_001428333.1 CDS secF NC_009749.1 832784 833728 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 832784..833728 Francisella tularensis subsp. holarctica FTNF002-00 5523275 YP_001428334.1 CDS FTA_0902 NC_009749.1 833760 834290 D hypothetical protein 833760..834290 Francisella tularensis subsp. holarctica FTNF002-00 5523276 YP_001428335.1 CDS rpoH NC_009749.1 834314 835192 D binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 834314..835192 Francisella tularensis subsp. holarctica FTNF002-00 5523277 YP_001428336.1 CDS aroA NC_009749.1 835283 836560 D 3-phosphoshikimate 1-carboxyvinyltransferase 835283..836560 Francisella tularensis subsp. holarctica FTNF002-00 5523278 YP_001428337.1 CDS FTA_0905 NC_009749.1 836563 837153 D hypothetical protein 836563..837153 Francisella tularensis subsp. holarctica FTNF002-00 5523279 YP_001428338.1 CDS rnhA NC_009749.1 837128 837586 D RNase H 837128..837586 Francisella tularensis subsp. holarctica FTNF002-00 5523280 YP_001428339.1 CDS FTA_0907 NC_009749.1 837588 838625 D L-asparaginase 837588..838625 Francisella tularensis subsp. holarctica FTNF002-00 5523281 YP_001428340.1 CDS FTA_0908 NC_009749.1 838696 839382 D carbonic anhydrase 838696..839382 Francisella tularensis subsp. holarctica FTNF002-00 5523282 YP_001428341.1 CDS FTA_0909 NC_009749.1 839669 840274 R hypothetical protein complement(839669..840274) Francisella tularensis subsp. holarctica FTNF002-00 5523283 YP_001428342.1 CDS FTA_0910 NC_009749.1 840338 841210 R hypothetical protein complement(840338..841210) Francisella tularensis subsp. holarctica FTNF002-00 5523284 YP_001428343.1 CDS rubA NC_009749.1 841219 841389 R rubredoxin complement(841219..841389) Francisella tularensis subsp. holarctica FTNF002-00 5523285 YP_001428344.1 CDS FTA_0912 NC_009749.1 841475 842092 R hypothetical protein complement(841475..842092) Francisella tularensis subsp. holarctica FTNF002-00 5523286 YP_001428345.1 CDS FTA_0913 NC_009749.1 842367 843026 D transposase ISFTu2 842367..843026 Francisella tularensis subsp. holarctica FTNF002-00 5523503 YP_001428346.1 CDS FTA_0914 NC_009749.1 843061 844455 D hypothetical protein 843061..844455 Francisella tularensis subsp. holarctica FTNF002-00 5523504 YP_001428347.2 CDS FTA_0915 NC_009749.1 844487 845761 R sodium-dicarboxylate symporter family protein complement(844487..845761) Francisella tularensis subsp. holarctica FTNF002-00 5523505 YP_001428348.1 CDS FTA_0916 NC_009749.1 845963 846991 D sugar isomerase 845963..846991 Francisella tularensis subsp. holarctica FTNF002-00 5523506 YP_001428349.1 CDS FTA_0917 NC_009749.1 847016 848419 D major facilitator superfamily sugar transporter 847016..848419 Francisella tularensis subsp. holarctica FTNF002-00 5523507 YP_001428350.1 CDS FTA_0918 NC_009749.1 848807 849115 D putative IS1 transposase 848807..849115 Francisella tularensis subsp. holarctica FTNF002-00 5523508 YP_001428351.1 CDS FTA_0919 NC_009749.1 849297 850754 R hypothetical protein complement(849297..850754) Francisella tularensis subsp. holarctica FTNF002-00 5523509 YP_001428354.1 CDS FTA_0922 NC_009749.1 851896 852135 D hypothetical protein 851896..852135 Francisella tularensis subsp. holarctica FTNF002-00 5523512 YP_001428355.1 CDS FTA_0923 NC_009749.1 852195 852374 D hypothetical protein 852195..852374 Francisella tularensis subsp. holarctica FTNF002-00 5523513 YP_001428356.2 CDS FTA_0924 NC_009749.1 852840 853340 D hypothetical protein 852840..853340 Francisella tularensis subsp. holarctica FTNF002-00 5523514 YP_001428357.1 CDS FTA_0925 NC_009749.1 853852 854094 R hypothetical protein complement(853852..854094) Francisella tularensis subsp. holarctica FTNF002-00 5523515 YP_001428358.1 CDS ispG NC_009749.1 854191 855396 D catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 854191..855396 Francisella tularensis subsp. holarctica FTNF002-00 5523516 YP_001428359.1 CDS FTA_0927 NC_009749.1 855411 856118 D hypothetical protein 855411..856118 Francisella tularensis subsp. holarctica FTNF002-00 5522571 YP_001428360.1 CDS FTA_0928 NC_009749.1 856137 857930 D M24 family metallopeptidase 856137..857930 Francisella tularensis subsp. holarctica FTNF002-00 5522572 YP_001428361.1 CDS FTA_0930 NC_009749.1 858028 859092 D DNA/RNA endonuclease 858028..859092 Francisella tularensis subsp. holarctica FTNF002-00 5522573 YP_001428362.1 CDS FTA_0929 NC_009749.1 859083 859946 R beta-lactamase complement(859083..859946) Francisella tularensis subsp. holarctica FTNF002-00 5522575 YP_001428363.1 CDS FTA_0931 NC_009749.1 860375 861325 D hypothetical protein 860375..861325 Francisella tularensis subsp. holarctica FTNF002-00 5522574 YP_001428364.1 CDS FTA_0932 NC_009749.1 861621 861896 R hypothetical protein complement(861621..861896) Francisella tularensis subsp. holarctica FTNF002-00 5522576 YP_001428365.1 CDS lnt NC_009749.1 862142 863632 R apolipoprotein N-acyltransferase complement(862142..863632) Francisella tularensis subsp. holarctica FTNF002-00 5522577 YP_001428366.1 CDS FTA_0934 NC_009749.1 863632 864474 R hypothetical protein complement(863632..864474) Francisella tularensis subsp. holarctica FTNF002-00 5522578 YP_001428367.1 CDS FTA_0935 NC_009749.1 864464 864952 R hypothetical protein complement(864464..864952) Francisella tularensis subsp. holarctica FTNF002-00 5522579 YP_001428368.2 CDS FTA_0936 NC_009749.1 864945 865928 R PhoH family protein complement(864945..865928) Francisella tularensis subsp. holarctica FTNF002-00 5522580 YP_001428369.1 CDS miaB NC_009749.1 865932 867260 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(865932..867260) Francisella tularensis subsp. holarctica FTNF002-00 5522581 YP_001428370.1 CDS FTA_0938 NC_009749.1 867522 868157 D o-methyltransferase family protein 867522..868157 Francisella tularensis subsp. holarctica FTNF002-00 5522582 YP_001428373.2 CDS tdk NC_009749.1 868925 869518 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 868925..869518 Francisella tularensis subsp. holarctica FTNF002-00 5523087 YP_001428374.1 CDS tig NC_009749.1 870181 871497 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 870181..871497 Francisella tularensis subsp. holarctica FTNF002-00 5523088 YP_001428375.1 CDS clpP NC_009749.1 871523 872128 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 871523..872128 Francisella tularensis subsp. holarctica FTNF002-00 5523089 YP_001428376.1 CDS clpX NC_009749.1 872152 873405 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 872152..873405 Francisella tularensis subsp. holarctica FTNF002-00 5523090 YP_001428377.1 CDS lon NC_009749.1 873430 875754 D DNA-binding, ATP-dependent protease La 873430..875754 Francisella tularensis subsp. holarctica FTNF002-00 5523091 YP_001428378.1 CDS FTA_0946 NC_009749.1 875841 876113 D DNA-binding protein HU 875841..876113 Francisella tularensis subsp. holarctica FTNF002-00 5523092 YP_001428379.1 CDS FTA_0947 NC_009749.1 876226 877659 D hypothetical protein 876226..877659 Francisella tularensis subsp. holarctica FTNF002-00 5523093 YP_001428380.1 CDS miaA NC_009749.1 877660 878586 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 877660..878586 Francisella tularensis subsp. holarctica FTNF002-00 5523094 YP_001428381.1 CDS FTA_0949 NC_009749.1 878697 879026 D host factor I for bacteriophage Q beta replication 878697..879026 Francisella tularensis subsp. holarctica FTNF002-00 5523095 YP_001428382.1 CDS FTA_0950 NC_009749.1 879174 880385 D protease, GTP-binding subunit 879174..880385 Francisella tularensis subsp. holarctica FTNF002-00 5523096 YP_001428386.1 CDS hflK NC_009749.1 881758 882825 D protease regulator HflK 881758..882825 Francisella tularensis subsp. holarctica FTNF002-00 5523100 YP_001428387.1 CDS hflC NC_009749.1 882827 883753 D protease regulator HflC 882827..883753 Francisella tularensis subsp. holarctica FTNF002-00 5524203 YP_001428388.1 CDS FTA_0956 NC_009749.1 883754 884239 D low molecular weight (LMW) phosphotyrosine protein phosphatase 883754..884239 Francisella tularensis subsp. holarctica FTNF002-00 5524204 YP_001428389.2 CDS engB NC_009749.1 884236 884829 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 884236..884829 Francisella tularensis subsp. holarctica FTNF002-00 5524205 YP_001428392.1 CDS FTA_0960 NC_009749.1 886267 886617 D hypothetical protein 886267..886617 Francisella tularensis subsp. holarctica FTNF002-00 5524208 YP_001428397.2 CDS FTA_0965 NC_009749.1 889878 890195 D acetolactate synthase small subunit 889878..890195 Francisella tularensis subsp. holarctica FTNF002-00 5524213 YP_001428398.1 CDS ilvC NC_009749.1 890223 891266 D ketol-acid reductoisomerase 890223..891266 Francisella tularensis subsp. holarctica FTNF002-00 5524214 YP_001428399.1 CDS mfd NC_009749.1 891389 894814 R transcription-repair coupling factor complement(891389..894814) Francisella tularensis subsp. holarctica FTNF002-00 5524215 YP_001428400.2 CDS FTA_0968 NC_009749.1 894859 895545 R hypothetical protein complement(894859..895545) Francisella tularensis subsp. holarctica FTNF002-00 5524216 YP_001428401.1 CDS FTA_0969 NC_009749.1 895661 896920 R hypothetical protein complement(895661..896920) Francisella tularensis subsp. holarctica FTNF002-00 5523545 YP_001428402.1 CDS FTA_0970 NC_009749.1 896920 897351 R hypothetical protein complement(896920..897351) Francisella tularensis subsp. holarctica FTNF002-00 5523546 YP_001428403.1 CDS nth NC_009749.1 897348 897986 R endonuclease III complement(897348..897986) Francisella tularensis subsp. holarctica FTNF002-00 5523547 YP_001428404.1 CDS FTA_0972 NC_009749.1 897979 898608 R RnfABCDGE type electron transport complex subunit B complement(897979..898608) Francisella tularensis subsp. holarctica FTNF002-00 5523548 YP_001428405.2 CDS FTA_0973 NC_009749.1 898610 899254 R cofactor involved in the reduction of disulfides; glutaredoxin complement(898610..899254) Francisella tularensis subsp. holarctica FTNF002-00 5523549 YP_001428408.1 CDS FTA_0976 NC_009749.1 900886 901386 R ferritin-like protein complement(900886..901386) Francisella tularensis subsp. holarctica FTNF002-00 5523552 YP_001428409.1 CDS lipA NC_009749.1 901592 902575 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 901592..902575 Francisella tularensis subsp. holarctica FTNF002-00 5523553 YP_001428410.1 CDS FTA_0978 NC_009749.1 902605 903264 D isoprenoid biosynthesis protein with amidotransferase-like domain 902605..903264 Francisella tularensis subsp. holarctica FTNF002-00 5523554 YP_001428411.1 CDS FTA_0979 NC_009749.1 903280 904026 D hypothetical protein 903280..904026 Francisella tularensis subsp. holarctica FTNF002-00 5523555 YP_001428412.1 CDS ruvC NC_009749.1 904123 904638 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 904123..904638 Francisella tularensis subsp. holarctica FTNF002-00 5523556 YP_001428413.1 CDS FTA_0981 NC_009749.1 904720 905910 D major facilitator transporter 904720..905910 Francisella tularensis subsp. holarctica FTNF002-00 5523557 YP_001428414.1 CDS ruvA NC_009749.1 905923 906573 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 905923..906573 Francisella tularensis subsp. holarctica FTNF002-00 5523558 YP_001428415.1 CDS FTA_0983 NC_009749.1 906599 908014 D DNA recombination protein 906599..908014 Francisella tularensis subsp. holarctica FTNF002-00 5523259 YP_001428416.1 CDS FTA_0984 NC_009749.1 908193 908642 D N terminal truncation compared to Schu4 and WY96-3418 ORFs; hypothetical protein 908193..908642 Francisella tularensis subsp. holarctica FTNF002-00 5523260 YP_001428417.1 CDS FTA_0985 NC_009749.1 908996 909337 R N-terminal truncation compared to balst hits; hypothetical protein complement(908996..909337) Francisella tularensis subsp. holarctica FTNF002-00 5523261 YP_001428418.1 CDS FTA_0987 NC_009749.1 909616 910428 D hypothetical protein 909616..910428 Francisella tularensis subsp. holarctica FTNF002-00 5523262 YP_001428419.1 CDS FTA_0986 NC_009749.1 910415 911551 R catalyzes the formation of histamine from L-histidine; histidine decarboxylase complement(910415..911551) Francisella tularensis subsp. holarctica FTNF002-00 5523264 YP_001428420.1 CDS FTA_0988 NC_009749.1 911566 912264 R aldolase/adducin class II family protein complement(911566..912264) Francisella tularensis subsp. holarctica FTNF002-00 5523263 YP_001428421.1 CDS FTA_0989 NC_009749.1 912355 912936 R 3-methyladenine DNA glycosylase complement(912355..912936) Francisella tularensis subsp. holarctica FTNF002-00 5523265 YP_001428422.2 CDS FTA_0990 NC_009749.1 913064 913567 D hypothetical protein 913064..913567 Francisella tularensis subsp. holarctica FTNF002-00 5523266 YP_001428423.1 CDS FTA_0991 NC_009749.1 913567 914199 D nicotinamide mononucleotide transporter 913567..914199 Francisella tularensis subsp. holarctica FTNF002-00 5523267 YP_001428424.2 CDS FTA_0992 NC_009749.1 914302 915477 D monovalent cation:proton antiporter-2 (CPA2) family protein 914302..915477 Francisella tularensis subsp. holarctica FTNF002-00 5523268 YP_001428425.2 CDS FTA_0993 NC_009749.1 915810 916271 R hypothetical protein complement(915810..916271) Francisella tularensis subsp. holarctica FTNF002-00 5523269 YP_001428430.2 CDS FTA_0998 NC_009749.1 919146 920078 R succinylglutamate desuccinylase/aspartoacylase family protein complement(919146..920078) Francisella tularensis subsp. holarctica FTNF002-00 5523000 YP_001428431.1 CDS FTA_0999 NC_009749.1 920363 921331 D ribose-phosphate pyrophosphokinase 920363..921331 Francisella tularensis subsp. holarctica FTNF002-00 5523001 YP_001428432.1 CDS FTA_1000 NC_009749.1 921431 921721 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 921431..921721 Francisella tularensis subsp. holarctica FTNF002-00 5523002 YP_001428433.1 CDS FTA_1001 NC_009749.1 921817 923076 D hypothetical protein 921817..923076 Francisella tularensis subsp. holarctica FTNF002-00 5523003 YP_001428437.1 CDS FTA_1005 NC_009749.1 924672 924947 R hypothetical protein complement(924672..924947) Francisella tularensis subsp. holarctica FTNF002-00 5523007 YP_001428438.1 CDS FTA_1006 NC_009749.1 924962 926053 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(924962..926053) Francisella tularensis subsp. holarctica FTNF002-00 5523008 YP_001428439.2 CDS pth NC_009749.1 926072 926647 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(926072..926647) Francisella tularensis subsp. holarctica FTNF002-00 5523009 YP_001428440.1 CDS FTA_1008 NC_009749.1 926640 927524 R beta-lactamase family protein complement(926640..927524) Francisella tularensis subsp. holarctica FTNF002-00 5523010 YP_001428441.1 CDS FTA_1009 NC_009749.1 927533 928378 R hypothetical protein complement(927533..928378) Francisella tularensis subsp. holarctica FTNF002-00 5523011 YP_001428442.2 CDS FTA_1010 NC_009749.1 928418 929236 R prepilin peptidase family protein complement(928418..929236) Francisella tularensis subsp. holarctica FTNF002-00 5523012 YP_001428443.2 CDS udhA NC_009749.1 929240 930655 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(929240..930655) Francisella tularensis subsp. holarctica FTNF002-00 5523434 YP_001428446.1 CDS FTA_1014 NC_009749.1 931971 933428 R amino acid transporter complement(931971..933428) Francisella tularensis subsp. holarctica FTNF002-00 5523437 YP_001428447.1 CDS hslU NC_009749.1 933526 934893 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(933526..934893) Francisella tularensis subsp. holarctica FTNF002-00 5523438 YP_001428448.1 CDS FTA_1016 NC_009749.1 934901 935473 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(934901..935473) Francisella tularensis subsp. holarctica FTNF002-00 5523439 YP_001428449.1 CDS FTA_1017 NC_009749.1 935644 936393 D hypothetical protein 935644..936393 Francisella tularensis subsp. holarctica FTNF002-00 5523440 YP_001428450.1 CDS FTA_1018 NC_009749.1 936396 937298 R lipoate-protein ligase /lipoyltransferase complement(936396..937298) Francisella tularensis subsp. holarctica FTNF002-00 5523441 YP_001428451.2 CDS tyrS NC_009749.1 937361 938602 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 937361..938602 Francisella tularensis subsp. holarctica FTNF002-00 5523442 YP_001428452.2 CDS FTA_1020 NC_009749.1 939006 939886 R programmed frameshift; transposase ISFtu1 complement(join(939006..939557,939557..939886)) Francisella tularensis subsp. holarctica FTNF002-00 5523443 YP_001428454.1 CDS FTA_1022 NC_009749.1 939954 941123 D FMN dependent dehydrogenase 939954..941123 Francisella tularensis subsp. holarctica FTNF002-00 5523445 YP_001428455.1 CDS FTA_1023 NC_009749.1 941146 941322 D hypothetical protein 941146..941322 Francisella tularensis subsp. holarctica FTNF002-00 5523446 YP_001428458.1 CDS FTA_1026 NC_009749.1 944267 945424 D iron-containing alcohol dehydrogenase 944267..945424 Francisella tularensis subsp. holarctica FTNF002-00 5523748 YP_001428459.1 CDS prmA NC_009749.1 945647 946492 D 50S ribosomal protein L11 methyltransferase 945647..946492 Francisella tularensis subsp. holarctica FTNF002-00 5523749 YP_001428460.1 CDS FTA_1028 NC_009749.1 946482 947465 D tRNA-dihydrouridine synthase, TIM-barrel family protein 946482..947465 Francisella tularensis subsp. holarctica FTNF002-00 5523750 YP_001428461.1 CDS FTA_1029 NC_009749.1 947695 950022 D putative N-6 DNA methylase 947695..950022 Francisella tularensis subsp. holarctica FTNF002-00 5523751 YP_001428462.1 CDS FTA_1030 NC_009749.1 950264 950650 D hypothetical protein 950264..950650 Francisella tularensis subsp. holarctica FTNF002-00 5523752 YP_001428464.1 CDS FTA_1032 NC_009749.1 951039 951353 D N-terminal truncation compared to Schu4 or WY96-3418 ORFs; hypothetical protein 951039..951353 Francisella tularensis subsp. holarctica FTNF002-00 5523754 YP_001428465.1 CDS FTA_1033 NC_009749.1 951359 952771 D hypothetical protein 951359..952771 Francisella tularensis subsp. holarctica FTNF002-00 5523755 YP_001428466.1 CDS FTA_1034 NC_009749.1 952791 953840 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(952791..953840) Francisella tularensis subsp. holarctica FTNF002-00 5523756 YP_001428467.1 CDS FTA_1035 NC_009749.1 953847 954449 R DJ-1/PfpI family protein complement(953847..954449) Francisella tularensis subsp. holarctica FTNF002-00 5523757 YP_001428468.1 CDS FTA_1037 NC_009749.1 954560 955606 D ABC transporter ATP-binding protein 954560..955606 Francisella tularensis subsp. holarctica FTNF002-00 5523758 YP_001428469.1 CDS FTA_1036 NC_009749.1 955603 956835 R bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta complement(955603..956835) Francisella tularensis subsp. holarctica FTNF002-00 5523760 YP_001428470.1 CDS FTA_1038 NC_009749.1 956842 957102 R glutaredoxin complement(956842..957102) Francisella tularensis subsp. holarctica FTNF002-00 5523759 YP_001428471.1 CDS nrdA NC_009749.1 957106 958878 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(957106..958878) Francisella tularensis subsp. holarctica FTNF002-00 5523488 YP_001428472.2 CDS mdh NC_009749.1 959082 960041 R Catalyzes the reversible oxidation of malate to oxaloacetate; malate dehydrogenase complement(959082..960041) Francisella tularensis subsp. holarctica FTNF002-00 5523489 YP_001428473.2 CDS FTA_1041 NC_009749.1 960201 960716 D hypothetical protein 960201..960716 Francisella tularensis subsp. holarctica FTNF002-00 5523490 YP_001428474.1 CDS FTA_1042 NC_009749.1 960732 961367 D ubiquinone biosynthesis protein 960732..961367 Francisella tularensis subsp. holarctica FTNF002-00 5523491 YP_001428475.1 CDS FTA_1043 NC_009749.1 961376 961945 R transglycosylase complement(961376..961945) Francisella tularensis subsp. holarctica FTNF002-00 5523492 YP_001428477.2 CDS FTA_1045 NC_009749.1 962568 963448 D programmed ribosomal frameshift; transposase ISFtu1 join(962568..962897,962897..963448) Francisella tularensis subsp. holarctica FTNF002-00 5523494 YP_001428480.1 CDS FTA_1048 NC_009749.1 963733 965223 R hypothetical protein complement(963733..965223) Francisella tularensis subsp. holarctica FTNF002-00 5523497 YP_001428481.1 CDS FTA_1049 NC_009749.1 965278 965877 R HAD superfamily hydrolase complement(965278..965877) Francisella tularensis subsp. holarctica FTNF002-00 5523498 YP_001428482.1 CDS FTA_1050 NC_009749.1 965955 966554 D anti-oxidant AhpCTSA family protein 965955..966554 Francisella tularensis subsp. holarctica FTNF002-00 5523499 YP_001428484.2 CDS FTA_1052 NC_009749.1 967189 967995 D N-terminal truncation compared to Schu4 and WY96-3418; hypothetical protein 967189..967995 Francisella tularensis subsp. holarctica FTNF002-00 5523501 YP_001428485.2 CDS FTA_1053 NC_009749.1 968101 968367 D C-terminal truncation compared to blast hits; putative alkylphosphonate utilization operon protein 968101..968367 Francisella tularensis subsp. holarctica FTNF002-00 5523502 YP_001428486.1 CDS FTA_1054 NC_009749.1 968440 968655 D hypothetical protein 968440..968655 Francisella tularensis subsp. holarctica FTNF002-00 5523302 YP_001428487.1 CDS FTA_1055 NC_009749.1 969064 969270 D Shorter ORF compared other Francsisella orthologs; hypothetical protein 969064..969270 Francisella tularensis subsp. holarctica FTNF002-00 5523303 YP_001428488.1 CDS FTA_1056 NC_009749.1 969388 970158 D N-terminal truncated compared to orthologs; hypothetical protein 969388..970158 Francisella tularensis subsp. holarctica FTNF002-00 5523304 YP_001428489.2 CDS dnaQ NC_009749.1 970188 970904 D DNA polymerase III subunit epsilon 970188..970904 Francisella tularensis subsp. holarctica FTNF002-00 5523305 YP_001428490.1 CDS FTA_1058 NC_009749.1 970898 971371 D D-alanyl-D-alanine carboxypeptidase 970898..971371 Francisella tularensis subsp. holarctica FTNF002-00 5523306 YP_001428491.2 CDS FTA_1059 NC_009749.1 971313 972767 D hypothetical protein 971313..972767 Francisella tularensis subsp. holarctica FTNF002-00 5523307 YP_001428496.1 CDS FTA_1064 NC_009749.1 974216 974677 D C-terminal truncated protein; putative NAD-dependent aldehyde dehydrogenase fragment 974216..974677 Francisella tularensis subsp. holarctica FTNF002-00 5523312 YP_001428499.1 CDS FTA_1067 NC_009749.1 975241 975513 D hypothetical protein 975241..975513 Francisella tularensis subsp. holarctica FTNF002-00 5523315 YP_001428500.1 CDS FTA_1068 NC_009749.1 975527 976258 D hypothetical protein 975527..976258 Francisella tularensis subsp. holarctica FTNF002-00 5523316 YP_001428501.1 CDS FTA_1069 NC_009749.1 976261 977130 R oxidative stress transcriptional regulator complement(976261..977130) Francisella tularensis subsp. holarctica FTNF002-00 5523559 YP_001428502.1 CDS FTA_1070 NC_009749.1 977228 977752 D AhpC/TSA family protein 977228..977752 Francisella tularensis subsp. holarctica FTNF002-00 5523560 YP_001428503.1 CDS FTA_1071 NC_009749.1 977755 978366 D short chain dehydrogenase 977755..978366 Francisella tularensis subsp. holarctica FTNF002-00 5523561 YP_001428504.2 CDS cmk NC_009749.1 978383 979087 R cytidylate kinase complement(978383..979087) Francisella tularensis subsp. holarctica FTNF002-00 5523562 YP_001428505.1 CDS serC NC_009749.1 979035 980087 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(979035..980087) Francisella tularensis subsp. holarctica FTNF002-00 5523563 YP_001428508.2 CDS FTA_1077 NC_009749.1 980407 981287 D programmed ribosomal frameshift; transposase ISFtu1 join(980407..980736,980736..981287) Francisella tularensis subsp. holarctica FTNF002-00 5523566 YP_001428509.1 CDS FTA_1076 NC_009749.1 981265 982320 R histidine acid phosphatase complement(981265..982320) Francisella tularensis subsp. holarctica FTNF002-00 5523568 YP_001428510.1 CDS hemF NC_009749.1 982345 983271 R catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase complement(982345..983271) Francisella tularensis subsp. holarctica FTNF002-00 5523567 YP_001428513.2 CDS rpsF NC_009749.1 984778 985140 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 984778..985140 Francisella tularensis subsp. holarctica FTNF002-00 5523571 YP_001428514.2 CDS rpsR NC_009749.1 985156 985374 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 985156..985374 Francisella tularensis subsp. holarctica FTNF002-00 5523572 YP_001428515.2 CDS rplI NC_009749.1 985384 985848 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 985384..985848 Francisella tularensis subsp. holarctica FTNF002-00 5523573 YP_001428516.2 CDS dnaB NC_009749.1 985936 987333 D replicative DNA helicase 985936..987333 Francisella tularensis subsp. holarctica FTNF002-00 5523028 YP_001428517.1 CDS FTA_1085 NC_009749.1 987364 988476 D radical SAM protein 987364..988476 Francisella tularensis subsp. holarctica FTNF002-00 5523029 YP_001428518.2 CDS FTA_1086 NC_009749.1 988409 989371 D hypothetical protein 988409..989371 Francisella tularensis subsp. holarctica FTNF002-00 5523030 YP_001428519.1 CDS FTA_1087 NC_009749.1 989364 990179 D RNA pseudouridine synthase B 989364..990179 Francisella tularensis subsp. holarctica FTNF002-00 5523031 YP_001428520.1 CDS FTA_1088 NC_009749.1 990179 990604 D hypothetical protein 990179..990604 Francisella tularensis subsp. holarctica FTNF002-00 5523032 YP_001428521.1 CDS FTA_1089 NC_009749.1 990582 991022 D acetyltransferase 990582..991022 Francisella tularensis subsp. holarctica FTNF002-00 5523033 YP_001428522.1 CDS FTA_1090 NC_009749.1 991148 991627 D C-terminal truncation due to preamture stop; hypothetical protein 991148..991627 Francisella tularensis subsp. holarctica FTNF002-00 5523034 YP_001428523.1 CDS FTA_1091 NC_009749.1 992400 992537 D hypothetical protein 992400..992537 Francisella tularensis subsp. holarctica FTNF002-00 5523035 YP_001428524.2 CDS FTA_1092 NC_009749.1 992798 993004 D hypothetical protein 992798..993004 Francisella tularensis subsp. holarctica FTNF002-00 5523036 YP_001428525.2 CDS FTA_1093 NC_009749.1 993450 993602 D hypothetical protein 993450..993602 Francisella tularensis subsp. holarctica FTNF002-00 5523037 YP_001428530.1 CDS FTA_1098 NC_009749.1 997112 997477 D hypothetical protein 997112..997477 Francisella tularensis subsp. holarctica FTNF002-00 5523042 YP_001428531.1 CDS FTA_1099 NC_009749.1 998144 998767 D hypothetical protein 998144..998767 Francisella tularensis subsp. holarctica FTNF002-00 5523704 YP_001428532.1 CDS FTA_1100 NC_009749.1 998848 999279 D hypothetical protein 998848..999279 Francisella tularensis subsp. holarctica FTNF002-00 5523705 YP_001428533.1 CDS FTA_1101 NC_009749.1 999369 1000346 D polyprenyl synthetase family protein 999369..1000346 Francisella tularensis subsp. holarctica FTNF002-00 5523706 YP_001428534.1 CDS FTA_1102 NC_009749.1 1000364 1001176 R FKBP-type peptidyl-prolyl cis-trans isomerase complement(1000364..1001176) Francisella tularensis subsp. holarctica FTNF002-00 5523707 YP_001428535.1 CDS FTA_1103 NC_009749.1 1001190 1001993 R hypothetical protein complement(1001190..1001993) Francisella tularensis subsp. holarctica FTNF002-00 5523708 YP_001428536.1 CDS FTA_1104 NC_009749.1 1001986 1002402 R hypothetical protein complement(1001986..1002402) Francisella tularensis subsp. holarctica FTNF002-00 5523709 YP_001428537.1 CDS FTA_1105 NC_009749.1 1002418 1003029 R lipoprotein complement(1002418..1003029) Francisella tularensis subsp. holarctica FTNF002-00 5523710 YP_001428538.1 CDS dacB NC_009749.1 1003030 1004433 R D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase complement(1003030..1004433) Francisella tularensis subsp. holarctica FTNF002-00 5523711 YP_001428539.1 CDS rpsU NC_009749.1 1004689 1004886 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1004689..1004886 Francisella tularensis subsp. holarctica FTNF002-00 5523712 YP_001428540.1 CDS FTA_1108 NC_009749.1 1004947 1005393 D GatB/Yqey domain-containing protein 1004947..1005393 Francisella tularensis subsp. holarctica FTNF002-00 5523713 YP_001428541.1 CDS dnaG NC_009749.1 1005414 1007231 D DNA primase 1005414..1007231 Francisella tularensis subsp. holarctica FTNF002-00 5523714 YP_001428542.1 CDS rpoD NC_009749.1 1007256 1008989 D RNA polymerase sigma-70 factor 1007256..1008989 Francisella tularensis subsp. holarctica FTNF002-00 5523715 YP_001428543.1 CDS FTA_1111 NC_009749.1 1009096 1010346 D NADH dehydrogenase 1009096..1010346 Francisella tularensis subsp. holarctica FTNF002-00 5523716 YP_001428549.1 CDS lipB NC_009749.1 1014404 1015024 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1014404..1015024) Francisella tularensis subsp. holarctica FTNF002-00 5524161 YP_001428550.2 CDS FTA_1118 NC_009749.1 1015034 1015318 R hypothetical protein complement(1015034..1015318) Francisella tularensis subsp. holarctica FTNF002-00 5524162 YP_001428551.1 CDS FTA_1119 NC_009749.1 1015351 1016685 R D-alanyl-D-alanine carboxypeptidase complement(1015351..1016685) Francisella tularensis subsp. holarctica FTNF002-00 5524163 YP_001428552.1 CDS ppa NC_009749.1 1016842 1017363 D inorganic pyrophosphatase 1016842..1017363 Francisella tularensis subsp. holarctica FTNF002-00 5524164 YP_001428553.2 CDS FTA_1121 NC_009749.1 1017454 1018002 D YrbI family phosphatase 1017454..1018002 Francisella tularensis subsp. holarctica FTNF002-00 5524165 YP_001428555.1 CDS FTA_1123 NC_009749.1 1018623 1019456 D hypothetical protein 1018623..1019456 Francisella tularensis subsp. holarctica FTNF002-00 5524167 YP_001428556.1 CDS FTA_1124 NC_009749.1 1019530 1020261 D ABC transporter ATP-binding protein 1019530..1020261 Francisella tularensis subsp. holarctica FTNF002-00 5524168 YP_001428557.1 CDS FTA_1125 NC_009749.1 1020310 1020903 D fumarylacetoacetate hydrolase family protein 1020310..1020903 Francisella tularensis subsp. holarctica FTNF002-00 5524169 YP_001428558.1 CDS FTA_1126 NC_009749.1 1020916 1022748 D possible bifunctional protein; phosphorylase family 2 protein 1020916..1022748 Francisella tularensis subsp. holarctica FTNF002-00 5524170 YP_001428559.1 CDS truA NC_009749.1 1022751 1023527 D mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1022751..1023527 Francisella tularensis subsp. holarctica FTNF002-00 5524171 YP_001428562.1 CDS guaA NC_009749.1 1025214 1026764 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1025214..1026764 Francisella tularensis subsp. holarctica FTNF002-00 5524120 YP_001428563.1 CDS dxs NC_009749.1 1026846 1028693 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 1026846..1028693 Francisella tularensis subsp. holarctica FTNF002-00 5524121 YP_001428564.1 CDS FTA_1132 NC_009749.1 1028709 1029044 D hypothetical protein 1028709..1029044 Francisella tularensis subsp. holarctica FTNF002-00 5524122 YP_001428565.1 CDS FTA_1133 NC_009749.1 1029066 1029695 D GDSL-like lipase/ acylhydrolase 1029066..1029695 Francisella tularensis subsp. holarctica FTNF002-00 5524123 YP_001428566.1 CDS FTA_1134 NC_009749.1 1029705 1030295 R hypothetical protein complement(1029705..1030295) Francisella tularensis subsp. holarctica FTNF002-00 5524124 YP_001428567.1 CDS FTA_1135 NC_009749.1 1030413 1031138 D short chain dehydrogenase family protein 1030413..1031138 Francisella tularensis subsp. holarctica FTNF002-00 5524125 YP_001428568.1 CDS ruvB NC_009749.1 1031202 1032248 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 1031202..1032248 Francisella tularensis subsp. holarctica FTNF002-00 5524126 YP_001428570.1 CDS FTA_1138 NC_009749.1 1033228 1033416 R hypothetical protein complement(1033228..1033416) Francisella tularensis subsp. holarctica FTNF002-00 5524128 YP_001428571.1 CDS FTA_1139 NC_009749.1 1033528 1033731 R helix-turn-helix domain-containing protein complement(1033528..1033731) Francisella tularensis subsp. holarctica FTNF002-00 5524129 YP_001428579.1 CDS FTA_1147 NC_009749.1 1036823 1037176 R hypothetical protein complement(1036823..1037176) Francisella tularensis subsp. holarctica FTNF002-00 5524106 YP_001428580.1 CDS FTA_1148 NC_009749.1 1037554 1038309 R linear amide C-N hydrolase/choloylglycine hydrolase family protein complement(1037554..1038309) Francisella tularensis subsp. holarctica FTNF002-00 5524108 YP_001428581.1 CDS FTA_1149 NC_009749.1 1038403 1039155 R rRNA methyltransferase complement(1038403..1039155) Francisella tularensis subsp. holarctica FTNF002-00 5524109 YP_001428584.1 CDS FTA_1151 NC_009749.1 1041244 1041720 R tryptophan-rich sensory (TspO)/MBR family protein complement(1041244..1041720) Francisella tularensis subsp. holarctica FTNF002-00 5524113 YP_001428585.1 CDS msrAB NC_009749.1 1041849 1042703 D this fusion consists of methionine sulfoxide B reductase at the N-terminus and A at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion protein of these enzymes with thioredoxin provides protection against oxidative stress in Neisseria gonorrhoeae; bifunctional methionine sulfoxide reductase B/A protein 1041849..1042703 Francisella tularensis subsp. holarctica FTNF002-00 5524112 YP_001428588.1 CDS FTA_1156 NC_009749.1 1044163 1045284 R DSBA-like thioredoxin domain-containing protein complement(1044163..1045284) Francisella tularensis subsp. holarctica FTNF002-00 5524116 YP_001428589.1 CDS FTA_1157 NC_009749.1 1045305 1045595 R lipoprotein complement(1045305..1045595) Francisella tularensis subsp. holarctica FTNF002-00 5524117 YP_001428592.2 CDS FTA_1160 NC_009749.1 1046772 1047179 R putative iojap-like protein complement(1046772..1047179) Francisella tularensis subsp. holarctica FTNF002-00 5522614 YP_001428593.1 CDS FTA_1161 NC_009749.1 1047210 1047545 D hypothetical protein 1047210..1047545 Francisella tularensis subsp. holarctica FTNF002-00 5522615 YP_001428598.1 CDS alaS NC_009749.1 1050056 1052653 D Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1050056..1052653 Francisella tularensis subsp. holarctica FTNF002-00 5522619 YP_001428599.2 CDS FTA_1167 NC_009749.1 1052661 1054043 D outer membrane efflux protein 1052661..1054043 Francisella tularensis subsp. holarctica FTNF002-00 5522621 YP_001428600.2 CDS FTA_1168 NC_009749.1 1054046 1055425 D cytosol aminopeptidase 1054046..1055425 Francisella tularensis subsp. holarctica FTNF002-00 5522622 YP_001428601.2 CDS tal NC_009749.1 1055505 1056524 D transaldolase B 1055505..1056524 Francisella tularensis subsp. holarctica FTNF002-00 5522623 YP_001428602.1 CDS FTA_1170 NC_009749.1 1056550 1057008 D hypothetical protein 1056550..1057008 Francisella tularensis subsp. holarctica FTNF002-00 5522624 YP_001428604.1 CDS FTA_1172 NC_009749.1 1057731 1058528 D transposase ISFTu2 1057731..1058528 Francisella tularensis subsp. holarctica FTNF002-00 5522626 YP_001428605.2 CDS FTA_1173 NC_009749.1 1058579 1059256 R nicotinamide mononucleotide transport (NMT) family protein complement(1058579..1059256) Francisella tularensis subsp. holarctica FTNF002-00 5522627 YP_001428606.2 CDS FTA_1174 NC_009749.1 1059253 1059771 R hypothetical protein complement(1059253..1059771) Francisella tularensis subsp. holarctica FTNF002-00 5522873 YP_001428607.2 CDS FTA_1175 NC_009749.1 1060379 1061125 D putative aminomethyl transferase/glycine cleavage T-protein 1060379..1061125 Francisella tularensis subsp. holarctica FTNF002-00 5522874 YP_001428608.1 CDS rep NC_009749.1 1061119 1063134 D ATP-dependent DNA helicase 1061119..1063134 Francisella tularensis subsp. holarctica FTNF002-00 5522875 YP_001428609.1 CDS FTA_1177 NC_009749.1 1063190 1064020 D hypothetical protein 1063190..1064020 Francisella tularensis subsp. holarctica FTNF002-00 5522876 YP_001428610.2 CDS FTA_1178 NC_009749.1 1064151 1065149 R rhodanese-like domain-containing protein complement(1064151..1065149) Francisella tularensis subsp. holarctica FTNF002-00 5522877 YP_001428611.1 CDS rdgC NC_009749.1 1065331 1066191 D Required for efficient pilin antigenic variation; recombination associated protein 1065331..1066191 Francisella tularensis subsp. holarctica FTNF002-00 5522878 YP_001428612.1 CDS FTA_1180 NC_009749.1 1066196 1066453 D hypothetical protein 1066196..1066453 Francisella tularensis subsp. holarctica FTNF002-00 5522879 YP_001428613.1 CDS FTA_1181 NC_009749.1 1067117 1067920 D hypothetical protein 1067117..1067920 Francisella tularensis subsp. holarctica FTNF002-00 5522880 YP_001428616.1 CDS FTA_1184 NC_009749.1 1068811 1069902 D hypothetical protein 1068811..1069902 Francisella tularensis subsp. holarctica FTNF002-00 5522883 YP_001428618.1 CDS FTA_1186 NC_009749.1 1070393 1071667 R HipA domain-containing protein complement(1070393..1071667) Francisella tularensis subsp. holarctica FTNF002-00 5522885 YP_001428619.1 CDS FTA_1187 NC_009749.1 1071652 1071879 R helix-turn-helix domain-containing protein complement(1071652..1071879) Francisella tularensis subsp. holarctica FTNF002-00 5522886 YP_001428620.1 CDS FTA_1188 NC_009749.1 1072177 1072353 D hypothetical protein 1072177..1072353 Francisella tularensis subsp. holarctica FTNF002-00 5522887 YP_001715626.1 CDS FTA_2150 NC_009749.1 1072461 1072580 D hypothetical protein 1072461..1072580 Francisella tularensis subsp. holarctica FTNF002-00 5983832 YP_001428621.2 CDS FTA_1189 NC_009749.1 1072667 1073547 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1072667..1073218,1073218..1073547)) Francisella tularensis subsp. holarctica FTNF002-00 5523244 YP_001428623.2 CDS FTA_1191 NC_009749.1 1073538 1073807 D hypothetical protein 1073538..1073807 Francisella tularensis subsp. holarctica FTNF002-00 5523246 YP_001428624.1 CDS FTA_1193 NC_009749.1 1073900 1074391 D GNAT family acetyltransferase 1073900..1074391 Francisella tularensis subsp. holarctica FTNF002-00 5523247 YP_001428627.1 CDS FTA_1195 NC_009749.1 1075649 1076437 R inositol monophosphatase family protein complement(1075649..1076437) Francisella tularensis subsp. holarctica FTNF002-00 5523250 YP_001428628.1 CDS FTA_1196 NC_009749.1 1076524 1077576 R hypothetical protein complement(1076524..1077576) Francisella tularensis subsp. holarctica FTNF002-00 5523251 YP_001428629.1 CDS FTA_1197 NC_009749.1 1077666 1078874 R hypothetical protein complement(1077666..1078874) Francisella tularensis subsp. holarctica FTNF002-00 5523252 YP_001428630.1 CDS FTA_1199 NC_009749.1 1078996 1079682 D hypothetical protein 1078996..1079682 Francisella tularensis subsp. holarctica FTNF002-00 5523253 YP_001428631.1 CDS FTA_1198 NC_009749.1 1079672 1079986 R YCII-related domain-containing protein complement(1079672..1079986) Francisella tularensis subsp. holarctica FTNF002-00 5523255 YP_001428632.1 CDS FTA_1200 NC_009749.1 1080037 1081296 R beta-ketoacyl-acyl carrier protein synthase II complement(1080037..1081296) Francisella tularensis subsp. holarctica FTNF002-00 5523254 YP_001428633.2 CDS acpP NC_009749.1 1081376 1081714 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(1081376..1081714) Francisella tularensis subsp. holarctica FTNF002-00 5523256 YP_001428634.1 CDS fabG NC_009749.1 1081757 1082500 R 3-oxoacyl-(acyl-carrier-protein) reductase complement(1081757..1082500) Francisella tularensis subsp. holarctica FTNF002-00 5523257 YP_001428635.1 CDS fabD NC_009749.1 1082514 1083434 R malonyl CoA-acyl carrier protein transacylase complement(1082514..1083434) Francisella tularensis subsp. holarctica FTNF002-00 5523258 YP_001428636.1 CDS FTA_1204 NC_009749.1 1083482 1084453 R 3-oxoacyl-(acyl-carrier-protein) synthase III complement(1083482..1084453) Francisella tularensis subsp. holarctica FTNF002-00 5523058 YP_001428637.1 CDS plsX NC_009749.1 1084550 1085596 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX complement(1084550..1085596) Francisella tularensis subsp. holarctica FTNF002-00 5523059 YP_001428638.1 CDS rpmF NC_009749.1 1085695 1085877 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(1085695..1085877) Francisella tularensis subsp. holarctica FTNF002-00 5523060 YP_001428639.1 CDS FTA_1207 NC_009749.1 1085921 1086424 R hypothetical protein complement(1085921..1086424) Francisella tularensis subsp. holarctica FTNF002-00 5523061 YP_001428640.1 CDS tkt NC_009749.1 1086563 1088554 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1086563..1088554 Francisella tularensis subsp. holarctica FTNF002-00 5523062 YP_001428641.2 CDS FTA_1209 NC_009749.1 1088535 1089593 D glyceraldehyde-3-phosphate dehydrogenase, type I 1088535..1089593 Francisella tularensis subsp. holarctica FTNF002-00 5523063 YP_001428642.1 CDS pgk NC_009749.1 1089612 1090790 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1089612..1090790 Francisella tularensis subsp. holarctica FTNF002-00 5523064 YP_001428643.1 CDS FTA_1211 NC_009749.1 1090806 1092242 D pyruvate kinase 1090806..1092242 Francisella tularensis subsp. holarctica FTNF002-00 5523065 YP_001428644.1 CDS fba NC_009749.1 1092261 1093325 D class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis; fructose-1,6-bisphosphate aldolase 1092261..1093325 Francisella tularensis subsp. holarctica FTNF002-00 5523066 YP_001428647.2 CDS FTA_1215 NC_009749.1 1095353 1096233 D programmed ribisomal frameshift; transposase ISFtu1 join(1095353..1095682,1095682..1096233) Francisella tularensis subsp. holarctica FTNF002-00 5523069 YP_001428649.1 CDS FTA_1217 NC_009749.1 1096234 1097106 R hypothetical protein complement(1096234..1097106) Francisella tularensis subsp. holarctica FTNF002-00 5523071 YP_001428652.2 CDS iglAII NC_009749.1 1097858 1098448 D Several genes in Francisella necessary for replication in macrophages and for virulence including iglA, iglC, and iglD and pathogenicity determinant protein genes pdpD and pdpA, are regulated by MglA. PMID:15375123, PMID:17000729; intracellular growth locus AII 1097858..1098448 Francisella tularensis subsp. holarctica FTNF002-00 5523130 YP_001428653.2 CDS iglB NC_009749.1 1098438 1099982 D intracellular growth locus BII 1098438..1099982 Francisella tularensis subsp. holarctica FTNF002-00 5523131 YP_001428654.1 CDS iglCII NC_009749.1 1099993 1100628 D intracellular growth locus CII 1099993..1100628 Francisella tularensis subsp. holarctica FTNF002-00 5523132 YP_001428655.2 CDS iglDII NC_009749.1 1100640 1101845 D Part of Francisella pathogenicity island. PMID: 15375123; intracellular growth locus DII 1100640..1101845 Francisella tularensis subsp. holarctica FTNF002-00 5523133 YP_001428657.1 CDS pdpCII NC_009749.1 1102445 1106431 R Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity determinant protein PdpC complement(1102445..1106431) Francisella tularensis subsp. holarctica FTNF002-00 5523135 YP_001428658.1 CDS FTA_1226 NC_009749.1 1106471 1107244 R hypothetical protein complement(1106471..1107244) Francisella tularensis subsp. holarctica FTNF002-00 5523136 YP_001428660.1 CDS FTA_1228 NC_009749.1 1108383 1109006 R hypothetical protein complement(1108383..1109006) Francisella tularensis subsp. holarctica FTNF002-00 5523138 YP_001428661.1 CDS FTA_1229 NC_009749.1 1109019 1110449 R hypothetical protein complement(1109019..1110449) Francisella tularensis subsp. holarctica FTNF002-00 5523139 YP_001428662.2 CDS FTA_1230 NC_009749.1 1110462 1110983 R hypothetical protein complement(1110462..1110983) Francisella tularensis subsp. holarctica FTNF002-00 5523140 YP_001428665.1 CDS FTA_1233 NC_009749.1 1113227 1113604 R putative lipoprotein complement(1113227..1113604) Francisella tularensis subsp. holarctica FTNF002-00 5523143 YP_001428666.1 CDS pdpBII NC_009749.1 1113594 1116875 R Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpB complement(1113594..1116875) Francisella tularensis subsp. holarctica FTNF002-00 5522931 YP_001428667.1 CDS pdpAII NC_009749.1 1116880 1119342 R Several Francisella pathogenicity island (FPI) genes, including iglC, iglD, and pdpA to pdpD, regulated by MglA are necessary for replication in macrophages and for virulence. PMID:15375123, PMID:17000729; pathogenicity deteminant protein PdpA complement(1116880..1119342) Francisella tularensis subsp. holarctica FTNF002-00 5522932 YP_001428668.1 CDS FTA_1237 NC_009749.1 1124922 1125506 R hypothetical protein complement(1124922..1125506) Francisella tularensis subsp. holarctica FTNF002-00 5524150 YP_001428669.1 CDS FTA_1238 NC_009749.1 1125753 1126676 R pyridoxal-phosphate dependent protein complement(1125753..1126676) Francisella tularensis subsp. holarctica FTNF002-00 5522934 YP_001428670.1 CDS FTA_1239 NC_009749.1 1127103 1127948 R probable truncation compared to homologs; choloylglycine hydrolase family lipoprotein complement(1127103..1127948) Francisella tularensis subsp. holarctica FTNF002-00 5522935 YP_001428673.1 CDS FTA_1242 NC_009749.1 1129004 1129198 D hypothetical protein 1129004..1129198 Francisella tularensis subsp. holarctica FTNF002-00 5522938 YP_001428674.1 CDS trmE NC_009749.1 1129208 1130560 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(1129208..1130560) Francisella tularensis subsp. holarctica FTNF002-00 5522939 YP_001428675.1 CDS FTA_1244 NC_009749.1 1130566 1130811 R hypothetical protein complement(1130566..1130811) Francisella tularensis subsp. holarctica FTNF002-00 5522940 YP_001428676.1 CDS FTA_1245 NC_009749.1 1130930 1131226 D ribosomal subunit interface protein yfiA/sigma 54 modulation protein 1130930..1131226 Francisella tularensis subsp. holarctica FTNF002-00 5522941 YP_001428677.1 CDS FTA_1246 NC_009749.1 1131263 1131718 D PEP-dependent sugar PTS system family protein 1131263..1131718 Francisella tularensis subsp. holarctica FTNF002-00 5522942 YP_001428678.1 CDS FTA_1247 NC_009749.1 1131711 1132454 D RNA methyltransferase 1131711..1132454 Francisella tularensis subsp. holarctica FTNF002-00 5522943 YP_001428679.1 CDS rnhB NC_009749.1 1132456 1133019 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1132456..1133019 Francisella tularensis subsp. holarctica FTNF002-00 5522944 YP_001428680.1 CDS FTA_1250 NC_009749.1 1133012 1134283 D sodium-solute symporter family protein 1133012..1134283 Francisella tularensis subsp. holarctica FTNF002-00 5522945 YP_001428681.1 CDS mglB NC_009749.1 1134280 1134687 R inferred from sequence similarity with MglB protein from F. novicida and function derived from mutation phenotype. PMID: 9701818; ClpXP protease specificity-enhancing factor complement(1134280..1134687) Francisella tularensis subsp. holarctica FTNF002-00 5522947 YP_001428682.2 CDS mglA NC_009749.1 1134689 1135306 R inferred from sequence similarity with MglB protein from F. novicida and function derived from mutation phenotype. PMID: 9701818; macrophage growth locus subunit A complement(1134689..1135306) Francisella tularensis subsp. holarctica FTNF002-00 5522946 YP_001428683.2 CDS rpsI NC_009749.1 1135366 1135764 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(1135366..1135764) Francisella tularensis subsp. holarctica FTNF002-00 5522948 YP_001428684.1 CDS rplM NC_009749.1 1135771 1136199 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(1135771..1136199) Francisella tularensis subsp. holarctica FTNF002-00 5522949 YP_001428685.1 CDS FTA_1254 NC_009749.1 1136338 1137522 R hypothetical protein complement(1136338..1137522) Francisella tularensis subsp. holarctica FTNF002-00 5522950 YP_001428686.1 CDS FTA_1255 NC_009749.1 1137515 1138666 R membrane-bound lytic murein transglycosylase A complement(1137515..1138666) Francisella tularensis subsp. holarctica FTNF002-00 5522951 YP_001428687.1 CDS grpE NC_009749.1 1138770 1139357 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1138770..1139357 Francisella tularensis subsp. holarctica FTNF002-00 5522952 YP_001428688.1 CDS dnaK NC_009749.1 1139458 1141386 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1139458..1141386 Francisella tularensis subsp. holarctica FTNF002-00 5522953 YP_001428689.2 CDS dnaJ NC_009749.1 1141412 1142590 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1141412..1142590 Francisella tularensis subsp. holarctica FTNF002-00 5522954 YP_001428690.1 CDS FTA_1259 NC_009749.1 1142604 1143392 R N-terminal truncation compared to Schu4 and WY96-3418; LysR family transcriptional regulator complement(1142604..1143392) Francisella tularensis subsp. holarctica FTNF002-00 5522955 YP_001428692.2 CDS FTA_1261 NC_009749.1 1143757 1144637 D programmed ribosomal frameshift; transposase ISFtu1 join(1143757..1144086,1144086..1144637) Francisella tularensis subsp. holarctica FTNF002-00 5522957 YP_001428696.1 CDS pheS NC_009749.1 1145606 1146619 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1145606..1146619 Francisella tularensis subsp. holarctica FTNF002-00 5523405 YP_001428697.1 CDS pheT NC_009749.1 1146640 1149012 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1146640..1149012 Francisella tularensis subsp. holarctica FTNF002-00 5523406 YP_001428698.2 CDS FTA_1267 NC_009749.1 1149055 1149486 R putative Fe2+/Zn2+ uptake regulation protein complement(1149055..1149486) Francisella tularensis subsp. holarctica FTNF002-00 5523407 YP_001428699.1 CDS FTA_1268 NC_009749.1 1149628 1150845 D cobalamin synthesis, cobW/P47K family protein 1149628..1150845 Francisella tularensis subsp. holarctica FTNF002-00 5523408 YP_001428700.1 CDS FTA_1269 NC_009749.1 1150848 1151594 D zinc/iron ABC transporter permease 1150848..1151594 Francisella tularensis subsp. holarctica FTNF002-00 5523409 YP_001428701.1 CDS FTA_1270 NC_009749.1 1151616 1152605 R hypothetical protein complement(1151616..1152605) Francisella tularensis subsp. holarctica FTNF002-00 5523410 YP_001428702.1 CDS FTA_1271 NC_009749.1 1152773 1154203 R phospholipase D complement(1152773..1154203) Francisella tularensis subsp. holarctica FTNF002-00 5523411 YP_001428703.1 CDS FTA_1272 NC_009749.1 1154295 1155722 R phospholipase D complement(1154295..1155722) Francisella tularensis subsp. holarctica FTNF002-00 5523412 YP_001428707.1 CDS FTA_1276 NC_009749.1 1157103 1157963 D hypothetical protein 1157103..1157963 Francisella tularensis subsp. holarctica FTNF002-00 5523416 YP_001428708.1 CDS dcd NC_009749.1 1157975 1158541 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 1157975..1158541 Francisella tularensis subsp. holarctica FTNF002-00 5523417 YP_001428711.2 CDS FTA_1280 NC_009749.1 1159799 1160374 R putative lipoprotein complement(1159799..1160374) Francisella tularensis subsp. holarctica FTNF002-00 5523043 YP_001428712.1 CDS leuS NC_009749.1 1160382 1162823 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(1160382..1162823) Francisella tularensis subsp. holarctica FTNF002-00 5523044 YP_001428713.1 CDS FTA_1282 NC_009749.1 1162931 1164826 R hypothetical protein complement(1162931..1164826) Francisella tularensis subsp. holarctica FTNF002-00 5523045 YP_001428716.1 CDS FTA_1285 NC_009749.1 1165626 1166036 R hypothetical protein complement(1165626..1166036) Francisella tularensis subsp. holarctica FTNF002-00 5523048 YP_001428717.1 CDS FTA_1286 NC_009749.1 1166038 1166622 R hypothetical protein complement(1166038..1166622) Francisella tularensis subsp. holarctica FTNF002-00 5523049 YP_001428719.2 CDS FTA_1288 NC_009749.1 1167256 1167627 R hypothetical protein complement(1167256..1167627) Francisella tularensis subsp. holarctica FTNF002-00 5523051 YP_001428721.2 CDS FTA_1290 NC_009749.1 1168281 1169405 R hypothetical protein complement(1168281..1169405) Francisella tularensis subsp. holarctica FTNF002-00 5523053 YP_001428722.1 CDS FTA_1291 NC_009749.1 1169737 1170978 R hypothetical protein complement(1169737..1170978) Francisella tularensis subsp. holarctica FTNF002-00 5523054 YP_001428723.1 CDS FTA_1292 NC_009749.1 1171207 1172574 D amino-acid permease 1171207..1172574 Francisella tularensis subsp. holarctica FTNF002-00 5523055 YP_001428724.1 CDS FTA_1293 NC_009749.1 1172626 1173231 D hypothetical protein 1172626..1173231 Francisella tularensis subsp. holarctica FTNF002-00 5523056 YP_001428725.2 CDS FTA_1295 NC_009749.1 1173235 1173528 D hypothetical protein 1173235..1173528 Francisella tularensis subsp. holarctica FTNF002-00 5523057 YP_001428727.1 CDS trx2 NC_009749.1 1173927 1174253 R thioredoxin complement(1173927..1174253) Francisella tularensis subsp. holarctica FTNF002-00 5524291 YP_001428728.1 CDS FTA_1297 NC_009749.1 1174257 1174946 R putative lipoprotein complement(1174257..1174946) Francisella tularensis subsp. holarctica FTNF002-00 5524293 YP_001428731.2 CDS FTA_1300 NC_009749.1 1175913 1177067 R sufB/SufD domain-containing protein complement(1175913..1177067) Francisella tularensis subsp. holarctica FTNF002-00 5524296 YP_001428732.1 CDS sufC NC_009749.1 1177071 1177820 R FeS assembly ATPase SufC complement(1177071..1177820) Francisella tularensis subsp. holarctica FTNF002-00 5524297 YP_001428733.1 CDS sufB NC_009749.1 1177859 1179304 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1177859..1179304) Francisella tularensis subsp. holarctica FTNF002-00 5524298 YP_001428734.1 CDS FTA_1303 NC_009749.1 1179311 1179721 R rrf2 family transcriptional regulator complement(1179311..1179721) Francisella tularensis subsp. holarctica FTNF002-00 5524299 YP_001428735.1 CDS trkA NC_009749.1 1179874 1181247 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1179874..1181247 Francisella tularensis subsp. holarctica FTNF002-00 5524300 YP_001428736.1 CDS FTA_1305 NC_009749.1 1181306 1182727 D amino acid antiporter 1181306..1182727 Francisella tularensis subsp. holarctica FTNF002-00 5524301 YP_001428739.2 CDS infA NC_009749.1 1183689 1183907 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(1183689..1183907) Francisella tularensis subsp. holarctica FTNF002-00 5524304 YP_001428740.1 CDS FTA_1309 NC_009749.1 1184067 1184906 D hypothetical protein 1184067..1184906 Francisella tularensis subsp. holarctica FTNF002-00 5524305 YP_001428741.1 CDS FTA_1310 NC_009749.1 1184903 1185169 D hypothetical protein 1184903..1185169 Francisella tularensis subsp. holarctica FTNF002-00 5523689 YP_001428742.1 CDS ffh NC_009749.1 1185250 1186626 D signal recognition particle protein 1185250..1186626 Francisella tularensis subsp. holarctica FTNF002-00 5523690 YP_001428743.1 CDS FTA_1312 NC_009749.1 1186658 1187770 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1186658..1187770 Francisella tularensis subsp. holarctica FTNF002-00 5523691 YP_001428744.2 CDS FTA_1313 NC_009749.1 1187958 1188838 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1187958..1188509,1188509..1188838)) Francisella tularensis subsp. holarctica FTNF002-00 5523692 YP_001428747.1 CDS FTA_1316 NC_009749.1 1189086 1189418 R hypothetical protein complement(1189086..1189418) Francisella tularensis subsp. holarctica FTNF002-00 5523695 YP_001428748.1 CDS xthA NC_009749.1 1189702 1190490 D exodeoxyribonuclease III 1189702..1190490 Francisella tularensis subsp. holarctica FTNF002-00 5523696 YP_001428749.1 CDS FTA_1318 NC_009749.1 1190511 1191218 D short chain dehydrogenase 1190511..1191218 Francisella tularensis subsp. holarctica FTNF002-00 5523697 YP_001428750.1 CDS FTA_1319 NC_009749.1 1191221 1191724 D hypothetical protein 1191221..1191724 Francisella tularensis subsp. holarctica FTNF002-00 5523698 YP_001428751.1 CDS FTA_1320 NC_009749.1 1191724 1192443 D hypothetical protein 1191724..1192443 Francisella tularensis subsp. holarctica FTNF002-00 5523699 YP_001428752.1 CDS gor NC_009749.1 1192481 1193842 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1192481..1193842 Francisella tularensis subsp. holarctica FTNF002-00 5523700 YP_001428753.1 CDS FTA_1322 NC_009749.1 1193853 1194173 D hypothetical protein 1193853..1194173 Francisella tularensis subsp. holarctica FTNF002-00 5523701 YP_001428754.1 CDS FTA_1323 NC_009749.1 1194390 1195082 D transposase ISFTu2 1194390..1195082 Francisella tularensis subsp. holarctica FTNF002-00 5523702 YP_001428755.1 CDS FTA_1325 NC_009749.1 1195169 1196710 D proton-dependent oligopeptide transporter (POT) family protein 1195169..1196710 Francisella tularensis subsp. holarctica FTNF002-00 5523703 YP_001428756.1 CDS FTA_1324 NC_009749.1 1196707 1198032 R DEAD/DEAH box helicase complement(1196707..1198032) Francisella tularensis subsp. holarctica FTNF002-00 5522544 YP_001428757.2 CDS folE NC_009749.1 1198159 1198779 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1198159..1198779 Francisella tularensis subsp. holarctica FTNF002-00 5522543 YP_001428760.1 CDS FTA_1329 NC_009749.1 1199626 1200057 D hypothetical protein 1199626..1200057 Francisella tularensis subsp. holarctica FTNF002-00 5522547 YP_001428765.1 CDS FTA_1334 NC_009749.1 1203401 1203955 R anthranilate synthase component II complement(1203401..1203955) Francisella tularensis subsp. holarctica FTNF002-00 5522552 YP_001428766.1 CDS FTA_1335 NC_009749.1 1203957 1205720 R chorismate-binding domain-containing protein complement(1203957..1205720) Francisella tularensis subsp. holarctica FTNF002-00 5522553 YP_001428767.1 CDS FTA_1336 NC_009749.1 1205713 1207095 R AMP-binding domain-containing protein complement(1205713..1207095) Francisella tularensis subsp. holarctica FTNF002-00 5522554 YP_001428768.1 CDS folB NC_009749.1 1207165 1207518 D dihydroneopterin aldolase 1207165..1207518 Francisella tularensis subsp. holarctica FTNF002-00 5522555 YP_001428769.1 CDS folK NC_009749.1 1207520 1208785 D 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 1207520..1208785 Francisella tularensis subsp. holarctica FTNF002-00 5522556 YP_001428770.1 CDS FTA_1339 NC_009749.1 1208798 1209718 D alpha/beta hydrolase fold protein 1208798..1209718 Francisella tularensis subsp. holarctica FTNF002-00 5522557 YP_001428771.1 CDS FTA_1340 NC_009749.1 1209734 1210234 D hypothetical protein 1209734..1210234 Francisella tularensis subsp. holarctica FTNF002-00 5523859 YP_001428775.2 CDS FTA_1344 NC_009749.1 1211396 1212727 R adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(1211396..1212727) Francisella tularensis subsp. holarctica FTNF002-00 5523863 YP_001428776.1 CDS bioB NC_009749.1 1212773 1213714 D biotin synthase 1212773..1213714 Francisella tularensis subsp. holarctica FTNF002-00 5523864 YP_001428777.1 CDS FTA_1346 NC_009749.1 1213708 1214835 D 8-amino-7-oxononanoate synthase 1213708..1214835 Francisella tularensis subsp. holarctica FTNF002-00 5523865 YP_001428778.1 CDS FTA_1347 NC_009749.1 1214813 1215550 D biotin synthesis protein BioC 1214813..1215550 Francisella tularensis subsp. holarctica FTNF002-00 5523866 YP_001428779.1 CDS bioD NC_009749.1 1215554 1216213 D dethiobiotin synthetase 1215554..1216213 Francisella tularensis subsp. holarctica FTNF002-00 5523867 YP_001428780.1 CDS FTA_1349 NC_009749.1 1216321 1217136 R C-terminal truncation compred to F. tularensis tularensis spp.; biotin-(acetyl-CoA-carboxylase) ligase domain-containing protein complement(1216321..1217136) Francisella tularensis subsp. holarctica FTNF002-00 5523868 YP_001428781.1 CDS FTA_1350 NC_009749.1 1217159 1218043 R ROK family protein complement(1217159..1218043) Francisella tularensis subsp. holarctica FTNF002-00 5523869 YP_001428782.1 CDS FTA_1351 NC_009749.1 1218045 1219304 R major facilitator superfamily transporter complement(1218045..1219304) Francisella tularensis subsp. holarctica FTNF002-00 5523870 YP_001428786.1 CDS FTA_1355 NC_009749.1 1221173 1222840 D glycoside hydrolase family protein 1221173..1222840 Francisella tularensis subsp. holarctica FTNF002-00 5523617 YP_001428787.1 CDS hemL NC_009749.1 1222861 1224156 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(1222861..1224156) Francisella tularensis subsp. holarctica FTNF002-00 5523618 YP_001428788.1 CDS gshB NC_009749.1 1224146 1225120 R catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase complement(1224146..1225120) Francisella tularensis subsp. holarctica FTNF002-00 5523619 YP_001428789.1 CDS fmt NC_009749.1 1225124 1226065 R methionyl-tRNA formyltransferase complement(1225124..1226065) Francisella tularensis subsp. holarctica FTNF002-00 5523620 YP_001428790.2 CDS FTA_1359 NC_009749.1 1226070 1226447 R hypothetical protein complement(1226070..1226447) Francisella tularensis subsp. holarctica FTNF002-00 5523621 YP_001428791.1 CDS rlmL NC_009749.1 1226570 1228723 R catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase complement(1226570..1228723) Francisella tularensis subsp. holarctica FTNF002-00 5523622 YP_001428792.1 CDS FTA_1361 NC_009749.1 1228798 1229352 R fatty acid hydroxylase complement(1228798..1229352) Francisella tularensis subsp. holarctica FTNF002-00 5523623 YP_001428793.1 CDS FTA_1362 NC_009749.1 1230074 1230196 D hypothetical protein 1230074..1230196 Francisella tularensis subsp. holarctica FTNF002-00 5524217 YP_001428794.2 CDS FTA_1363 NC_009749.1 1230318 1230812 R hypothetical protein complement(1230318..1230812) Francisella tularensis subsp. holarctica FTNF002-00 5523625 YP_001428795.2 CDS FTA_1364 NC_009749.1 1230784 1231664 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1230784..1231335,1231335..1231664)) Francisella tularensis subsp. holarctica FTNF002-00 5523626 YP_001428797.1 CDS FTA_1366 NC_009749.1 1231758 1232876 D hypothetical protein 1231758..1232876 Francisella tularensis subsp. holarctica FTNF002-00 5523628 YP_001428798.1 CDS FTA_1367 NC_009749.1 1232930 1233400 D hypothetical protein 1232930..1233400 Francisella tularensis subsp. holarctica FTNF002-00 5523629 YP_001428799.1 CDS FTA_1368 NC_009749.1 1233537 1234361 D oxidoreductase, short-chain dehydrogenase family protein 1233537..1234361 Francisella tularensis subsp. holarctica FTNF002-00 5523630 YP_001428802.1 CDS FTA_1371 NC_009749.1 1235968 1236840 R hypothetical protein complement(1235968..1236840) Francisella tularensis subsp. holarctica FTNF002-00 5524030 YP_001428803.2 CDS FTA_1372 NC_009749.1 1237008 1237888 D programmed ribosomal frameshift; transposase ISFtu1 join(1237008..1237337,1237337..1237888) Francisella tularensis subsp. holarctica FTNF002-00 5524031 YP_001428805.1 CDS FTA_1374 NC_009749.1 1237916 1238365 R hypothetical protein complement(1237916..1238365) Francisella tularensis subsp. holarctica FTNF002-00 5524033 YP_001428806.2 CDS FTA_1375 NC_009749.1 1238374 1238769 R hypothetical protein complement(1238374..1238769) Francisella tularensis subsp. holarctica FTNF002-00 5524034 YP_001428808.1 CDS FTA_1377 NC_009749.1 1239710 1240441 D oxidoreductase FAD/NAD-binding subunit 1239710..1240441 Francisella tularensis subsp. holarctica FTNF002-00 5524036 YP_001428809.1 CDS rpmE NC_009749.1 1240524 1240781 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1240524..1240781 Francisella tularensis subsp. holarctica FTNF002-00 5524037 YP_001428810.1 CDS gshA NC_009749.1 1240990 1242495 R glutamate--cysteine ligase complement(1240990..1242495) Francisella tularensis subsp. holarctica FTNF002-00 5524038 YP_001428811.1 CDS mviN NC_009749.1 1242548 1244089 R integral membrane protein MviN complement(1242548..1244089) Francisella tularensis subsp. holarctica FTNF002-00 5524039 YP_001428812.1 CDS FTA_1381 NC_009749.1 1244112 1245173 R hypothetical protein complement(1244112..1245173) Francisella tularensis subsp. holarctica FTNF002-00 5524040 YP_001428813.1 CDS FTA_1382 NC_009749.1 1245256 1245666 R hypothetical protein complement(1245256..1245666) Francisella tularensis subsp. holarctica FTNF002-00 5524041 YP_001428814.2 CDS FTA_1383 NC_009749.1 1245644 1246825 R bifunctional folylpolyglutamate synthase/ dihydrofolate synthase family protein complement(1245644..1246825) Francisella tularensis subsp. holarctica FTNF002-00 5524042 YP_001428815.2 CDS accD NC_009749.1 1246840 1247748 R acetyl-CoA carboxylase, carboxyltransferase subunit beta complement(1246840..1247748) Francisella tularensis subsp. holarctica FTNF002-00 5524043 YP_001428816.1 CDS ndk NC_009749.1 1247784 1248206 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1247784..1248206) Francisella tularensis subsp. holarctica FTNF002-00 5524134 YP_001428817.1 CDS pyrG NC_009749.1 1248279 1249919 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(1248279..1249919) Francisella tularensis subsp. holarctica FTNF002-00 5524135 YP_001428820.2 CDS FTA_1389 NC_009749.1 1251743 1252675 R hypothetical protein complement(1251743..1252675) Francisella tularensis subsp. holarctica FTNF002-00 5524138 YP_001428821.2 CDS FTA_1390 NC_009749.1 1252697 1253131 R hypothetical protein complement(1252697..1253131) Francisella tularensis subsp. holarctica FTNF002-00 5524139 YP_001428822.2 CDS FTA_1391 NC_009749.1 1253122 1254002 D programmed ribosomal frameshift; transposase ISFtu1 join(1253122..1253451,1253451..1254002) Francisella tularensis subsp. holarctica FTNF002-00 5524140 YP_001428824.2 CDS FTA_1393 NC_009749.1 1254198 1255193 R hypothetical protein complement(1254198..1255193) Francisella tularensis subsp. holarctica FTNF002-00 5524142 YP_001428826.2 CDS FTA_1395 NC_009749.1 1256448 1257059 R CRISPR-associated protein Cas4 complement(1256448..1257059) Francisella tularensis subsp. holarctica FTNF002-00 5524144 YP_001428827.1 CDS FTA_1396 NC_009749.1 1257007 1257300 R hypothetical protein complement(1257007..1257300) Francisella tularensis subsp. holarctica FTNF002-00 5524145 YP_001428834.2 CDS FTA_1403 NC_009749.1 1263985 1265166 R OmpA (outer membrane protein A) family protein complement(1263985..1265166) Francisella tularensis subsp. holarctica FTNF002-00 5523232 YP_001428835.1 CDS FTA_1404 NC_009749.1 1265273 1265518 R 4Fe-4S ferredoxin complement(1265273..1265518) Francisella tularensis subsp. holarctica FTNF002-00 5523233 YP_001428836.1 CDS coaD NC_009749.1 1265523 1266011 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1265523..1266011) Francisella tularensis subsp. holarctica FTNF002-00 5523234 YP_001428837.1 CDS FTA_1406 NC_009749.1 1266023 1266574 R hypothetical protein complement(1266023..1266574) Francisella tularensis subsp. holarctica FTNF002-00 5523235 YP_001428838.1 CDS FTA_1407 NC_009749.1 1266588 1266944 R iron-sulfur cluster assembly accessory protein complement(1266588..1266944) Francisella tularensis subsp. holarctica FTNF002-00 5523236 YP_001428839.1 CDS FTA_1408 NC_009749.1 1266965 1268188 R selenocysteine lyase complement(1266965..1268188) Francisella tularensis subsp. holarctica FTNF002-00 5523237 YP_001428840.1 CDS FTA_1409 NC_009749.1 1268291 1269664 R L-serine ammonia-lyase complement(1268291..1269664) Francisella tularensis subsp. holarctica FTNF002-00 5523238 YP_001428841.1 CDS FTA_1410 NC_009749.1 1269720 1270388 R hypothetical protein complement(1269720..1270388) Francisella tularensis subsp. holarctica FTNF002-00 5523239 YP_001428842.1 CDS pheA NC_009749.1 1270414 1271256 R prephenate dehydratase complement(1270414..1271256) Francisella tularensis subsp. holarctica FTNF002-00 5523240 YP_001428845.2 CDS alr NC_009749.1 1273032 1274129 R alanine racemase complement(1273032..1274129) Francisella tularensis subsp. holarctica FTNF002-00 5523243 YP_001428848.2 CDS FTA_1417 NC_009749.1 1275755 1276462 R hypothetical protein complement(1275755..1276462) Francisella tularensis subsp. holarctica FTNF002-00 5524241 YP_001428849.1 CDS FTA_1418 NC_009749.1 1276474 1276872 R hypothetical protein complement(1276474..1276872) Francisella tularensis subsp. holarctica FTNF002-00 5524242 YP_001428851.2 CDS FTA_1421 NC_009749.1 1276952 1277974 D hypothetical protein 1276952..1277974 Francisella tularensis subsp. holarctica FTNF002-00 5524244 YP_001428850.1 CDS FTA_1419 NC_009749.1 1277023 1277166 R hypothetical protein complement(1277023..1277166) Francisella tularensis subsp. holarctica FTNF002-00 5524243 YP_001428857.1 CDS FTA_1426 NC_009749.1 1281333 1282172 D transposase ISFTu2 1281333..1282172 Francisella tularensis subsp. holarctica FTNF002-00 5524250 YP_001428859.1 CDS glyS NC_009749.1 1282931 1285015 R glycyl-tRNA synthetase subunit beta complement(1282931..1285015) Francisella tularensis subsp. holarctica FTNF002-00 5524252 YP_001428860.1 CDS FTA_1429 NC_009749.1 1285208 1285882 D TatD hydrolase family protein 1285208..1285882 Francisella tularensis subsp. holarctica FTNF002-00 5524253 YP_001428861.1 CDS FTA_1430 NC_009749.1 1285886 1286935 D DNA replication and repair protein RecF 1285886..1286935 Francisella tularensis subsp. holarctica FTNF002-00 5524276 YP_001428862.1 CDS FTA_1431 NC_009749.1 1286957 1287250 D hypothetical protein 1286957..1287250 Francisella tularensis subsp. holarctica FTNF002-00 5524277 YP_001428863.1 CDS FTA_1432 NC_009749.1 1287335 1287541 D putative lipoprotein 1287335..1287541 Francisella tularensis subsp. holarctica FTNF002-00 5524278 YP_001428864.1 CDS FTA_1433 NC_009749.1 1287544 1288461 R hypothetical protein complement(1287544..1288461) Francisella tularensis subsp. holarctica FTNF002-00 5524279 YP_001428865.1 CDS FTA_1434 NC_009749.1 1288473 1289345 R Missing N-terminal residues; acyl-co A synthetase fragment complement(1288473..1289345) Francisella tularensis subsp. holarctica FTNF002-00 5524280 YP_001428866.1 CDS galU NC_009749.1 1289934 1290797 R UTP--glucose-1-phosphate uridylyltransferase complement(1289934..1290797) Francisella tularensis subsp. holarctica FTNF002-00 5524281 YP_001428867.1 CDS FTA_1436 NC_009749.1 1290814 1291953 R cation-efflux family protein complement(1290814..1291953) Francisella tularensis subsp. holarctica FTNF002-00 5524282 YP_001428871.1 CDS rpsU NC_009749.1 1293481 1293681 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1293481..1293681) Francisella tularensis subsp. holarctica FTNF002-00 5524286 YP_001428872.1 CDS FTA_1441 NC_009749.1 1294058 1294255 D hypothetical protein 1294058..1294255 Francisella tularensis subsp. holarctica FTNF002-00 5524287 YP_001428873.1 CDS FTA_1442 NC_009749.1 1294454 1294657 D cold-shock DNA-binding domain-containing protein 1294454..1294657 Francisella tularensis subsp. holarctica FTNF002-00 5524288 YP_001428874.1 CDS FTA_1443 NC_009749.1 1294728 1295714 R hypothetical protein complement(1294728..1295714) Francisella tularensis subsp. holarctica FTNF002-00 5524289 YP_001428875.1 CDS FTA_1444 NC_009749.1 1296236 1296919 D missing N-terminal residues compared to other Francisella strains; hypothetical protein 1296236..1296919 Francisella tularensis subsp. holarctica FTNF002-00 5524290 YP_001428876.1 CDS FTA_1445 NC_009749.1 1296943 1297662 R putative transcriptional regulator, IclR family protein complement(1296943..1297662) Francisella tularensis subsp. holarctica FTNF002-00 5524044 YP_001428881.2 CDS FTA_1450 NC_009749.1 1300390 1301270 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1300390..1300941,1300941..1301270)) Francisella tularensis subsp. holarctica FTNF002-00 5524049 YP_001428883.1 CDS FTA_1452 NC_009749.1 1301646 1302461 R hypothetical protein complement(1301646..1302461) Francisella tularensis subsp. holarctica FTNF002-00 5524051 YP_001428889.1 CDS FTA_1458 NC_009749.1 1308419 1308547 D hypothetical protein 1308419..1308547 Francisella tularensis subsp. holarctica FTNF002-00 5524057 YP_001428890.1 CDS FTA_1459 NC_009749.1 1308564 1308932 D S4 domain-containing protein 1308564..1308932 Francisella tularensis subsp. holarctica FTNF002-00 5524058 YP_001428891.2 CDS FTA_1460 NC_009749.1 1308967 1310460 R putative carbohydrate kinase/YjeF-like protein complement(1308967..1310460) Francisella tularensis subsp. holarctica FTNF002-00 5522888 YP_001428892.1 CDS FTA_1461 NC_009749.1 1310489 1310668 R hypothetical protein complement(1310489..1310668) Francisella tularensis subsp. holarctica FTNF002-00 5522889 YP_001428893.1 CDS FTA_1462 NC_009749.1 1310628 1310756 D hypothetical protein 1310628..1310756 Francisella tularensis subsp. holarctica FTNF002-00 5522890 YP_001428894.1 CDS FTA_1463 NC_009749.1 1310767 1311414 R hypothetical protein complement(1310767..1311414) Francisella tularensis subsp. holarctica FTNF002-00 5522891 YP_001428900.1 CDS FTA_1469 NC_009749.1 1313704 1314174 R glutathione peroxidase complement(1313704..1314174) Francisella tularensis subsp. holarctica FTNF002-00 5522897 YP_001428901.2 CDS FTA_1470 NC_009749.1 1314203 1314550 R chorismate mutase complement(1314203..1314550) Francisella tularensis subsp. holarctica FTNF002-00 5522898 YP_001428902.1 CDS FTA_1471 NC_009749.1 1314647 1315093 D hypothetical protein 1314647..1315093 Francisella tularensis subsp. holarctica FTNF002-00 5522899 YP_001428903.1 CDS FTA_1472 NC_009749.1 1315268 1315951 R transposase ISFTu2 complement(1315268..1315951) Francisella tularensis subsp. holarctica FTNF002-00 5522900 YP_001428906.1 CDS nadB NC_009749.1 1317183 1318670 R L-aspartate oxidase complement(1317183..1318670) Francisella tularensis subsp. holarctica FTNF002-00 5523530 YP_001428907.1 CDS nadC NC_009749.1 1318673 1319536 R nicotinate-nucleotide pyrophosphorylase complement(1318673..1319536) Francisella tularensis subsp. holarctica FTNF002-00 5523531 YP_001428908.1 CDS nadA NC_009749.1 1319545 1320570 R 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase complement(1319545..1320570) Francisella tularensis subsp. holarctica FTNF002-00 5523532 YP_001428909.1 CDS gmk NC_009749.1 1320591 1321163 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1320591..1321163) Francisella tularensis subsp. holarctica FTNF002-00 5523533 YP_001428910.1 CDS FTA_1479 NC_009749.1 1321280 1322989 R DEAD/DEAH box helicase complement(1321280..1322989) Francisella tularensis subsp. holarctica FTNF002-00 5523534 YP_001428911.1 CDS FTA_1480 NC_009749.1 1323024 1323302 R peptidyl-prolyl cis-trans isomerase domain-containing protein complement(1323024..1323302) Francisella tularensis subsp. holarctica FTNF002-00 5523535 YP_001428912.1 CDS FTA_1481 NC_009749.1 1323397 1324791 R major facilitator superfamily sugar transporter complement(1323397..1324791) Francisella tularensis subsp. holarctica FTNF002-00 5523536 YP_001428913.2 CDS FTA_1482 NC_009749.1 1324823 1326178 R major facilitator superfamily sugar transporter complement(1324823..1326178) Francisella tularensis subsp. holarctica FTNF002-00 5523537 YP_001428914.1 CDS galT NC_009749.1 1326294 1327319 D catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1326294..1327319 Francisella tularensis subsp. holarctica FTNF002-00 5523538 YP_001428915.2 CDS galK NC_009749.1 1327322 1328470 D galactokinase 1327322..1328470 Francisella tularensis subsp. holarctica FTNF002-00 5523539 YP_001428916.1 CDS FTA_1484 NC_009749.1 1328467 1328862 R histidine triad domain-containing protein complement(1328467..1328862) Francisella tularensis subsp. holarctica FTNF002-00 5523541 YP_001428917.1 CDS kdsB NC_009749.1 1328855 1329607 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(1328855..1329607) Francisella tularensis subsp. holarctica FTNF002-00 5523540 YP_001428918.2 CDS FTA_1487 NC_009749.1 1329600 1329848 R hypothetical protein complement(1329600..1329848) Francisella tularensis subsp. holarctica FTNF002-00 5523542 YP_001428919.2 CDS FTA_1488 NC_009749.1 1330417 1331297 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1330417..1330968,1330968..1331297)) Francisella tularensis subsp. holarctica FTNF002-00 5523543 YP_001428921.1 CDS FTA_1490 NC_009749.1 1331589 1332293 R hypothetical protein complement(1331589..1332293) Francisella tularensis subsp. holarctica FTNF002-00 5523287 YP_001428922.1 CDS rplT NC_009749.1 1332335 1332691 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1332335..1332691) Francisella tularensis subsp. holarctica FTNF002-00 5523288 YP_001428923.1 CDS rpmI NC_009749.1 1332727 1332924 R 50S ribosomal protein L35 complement(1332727..1332924) Francisella tularensis subsp. holarctica FTNF002-00 5523289 YP_001428924.2 CDS infC NC_009749.1 1332967 1333488 R translation initiation factor IF-3 complement(1332967..1333488) Francisella tularensis subsp. holarctica FTNF002-00 5523290 YP_001428925.1 CDS thrS NC_009749.1 1333510 1335414 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(1333510..1335414) Francisella tularensis subsp. holarctica FTNF002-00 5523291 YP_001428927.1 CDS FTA_1496 NC_009749.1 1337721 1338017 R hypothetical protein complement(1337721..1338017) Francisella tularensis subsp. holarctica FTNF002-00 5523293 YP_001428928.1 CDS gcvH2 NC_009749.1 1338007 1338387 R glycine cleavage system protein H complement(1338007..1338387) Francisella tularensis subsp. holarctica FTNF002-00 5523294 YP_001428929.1 CDS murG NC_009749.1 1338491 1339606 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1338491..1339606 Francisella tularensis subsp. holarctica FTNF002-00 5523295 YP_001428930.1 CDS FTA_1499 NC_009749.1 1339616 1339954 D hypothetical protein 1339616..1339954 Francisella tularensis subsp. holarctica FTNF002-00 5523296 YP_001428931.1 CDS recR NC_009749.1 1339954 1340556 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1339954..1340556 Francisella tularensis subsp. holarctica FTNF002-00 5523297 YP_001428932.2 CDS FTA_1501 NC_009749.1 1340564 1342687 R RelA/SpoT family protein complement(1340564..1342687) Francisella tularensis subsp. holarctica FTNF002-00 5523298 YP_001428933.2 CDS FTA_1502 NC_009749.1 1342747 1343958 R hypothetical protein complement(1342747..1343958) Francisella tularensis subsp. holarctica FTNF002-00 5523299 YP_001428934.1 CDS FTA_1503 NC_009749.1 1343960 1344424 R capsule biosynthesis protein CapC complement(1343960..1344424) Francisella tularensis subsp. holarctica FTNF002-00 5523300 YP_001428935.2 CDS FTA_1504 NC_009749.1 1344449 1345666 R hypothetical protein complement(1344449..1345666) Francisella tularensis subsp. holarctica FTNF002-00 5523301 YP_001428936.1 CDS FTA_1505 NC_009749.1 1345742 1346998 R major facilitator transporter complement(1345742..1346998) Francisella tularensis subsp. holarctica FTNF002-00 5524434 YP_001428937.1 CDS FTA_1506 NC_009749.1 1347670 1348533 R asparaginase complement(1347670..1348533) Francisella tularensis subsp. holarctica FTNF002-00 5524223 YP_001428938.2 CDS FTA_1507 NC_009749.1 1348749 1349567 R cyanophycinase complement(1348749..1349567) Francisella tularensis subsp. holarctica FTNF002-00 5524436 YP_001428939.1 CDS FTA_1508 NC_009749.1 1349770 1350876 D pfkB family sugar kinase 1349770..1350876 Francisella tularensis subsp. holarctica FTNF002-00 5524437 YP_001428940.1 CDS FTA_1509 NC_009749.1 1351158 1351820 R HAD family hydrolase complement(1351158..1351820) Francisella tularensis subsp. holarctica FTNF002-00 5524438 YP_001428941.1 CDS FTA_1510 NC_009749.1 1351839 1352852 R glycosyl transferases group 1 family protein complement(1351839..1352852) Francisella tularensis subsp. holarctica FTNF002-00 5524439 YP_001428942.1 CDS FTA_1511 NC_009749.1 1352855 1353862 R glycosyl transferase group 2 family protein complement(1352855..1353862) Francisella tularensis subsp. holarctica FTNF002-00 5524440 YP_001428943.1 CDS FTA_1512 NC_009749.1 1353879 1354838 R glycosyl transferase group 2 family protein complement(1353879..1354838) Francisella tularensis subsp. holarctica FTNF002-00 5524441 YP_001428944.2 CDS FTA_1513 NC_009749.1 1354847 1355608 R hypothetical protein complement(1354847..1355608) Francisella tularensis subsp. holarctica FTNF002-00 5524442 YP_001428945.2 CDS FTA_1514 NC_009749.1 1355612 1356307 R hypothetical protein complement(1355612..1356307) Francisella tularensis subsp. holarctica FTNF002-00 5524443 YP_001428946.1 CDS FTA_1515 NC_009749.1 1356234 1357520 R HAD family hydrolase complement(1356234..1357520) Francisella tularensis subsp. holarctica FTNF002-00 5524444 YP_001428947.1 CDS FTA_1516 NC_009749.1 1357534 1359216 R ABC transporter ATP-binding protein complement(1357534..1359216) Francisella tularensis subsp. holarctica FTNF002-00 5524445 YP_001428948.1 CDS FTA_1517 NC_009749.1 1359213 1360442 R glycosyl transferase family protein complement(1359213..1360442) Francisella tularensis subsp. holarctica FTNF002-00 5524446 YP_001428949.1 CDS galE NC_009749.1 1360446 1361465 R UDP-glucose 4-epimerase complement(1360446..1361465) Francisella tularensis subsp. holarctica FTNF002-00 5524447 YP_001428950.2 CDS FTA_1519 NC_009749.1 1361458 1362852 R sugar transferase complement(1361458..1362852) Francisella tularensis subsp. holarctica FTNF002-00 5524448 YP_001428951.1 CDS rpe NC_009749.1 1362833 1363501 R D-ribulose-phosphate 3-epimerase complement(1362833..1363501) Francisella tularensis subsp. holarctica FTNF002-00 5524621 YP_001428952.2 CDS FTA_1521 NC_009749.1 1363626 1364609 D sugar isomerase 1363626..1364609 Francisella tularensis subsp. holarctica FTNF002-00 5524622 YP_001428953.2 CDS FTA_1522 NC_009749.1 1364613 1365203 R hypothetical protein complement(1364613..1365203) Francisella tularensis subsp. holarctica FTNF002-00 5524623 YP_001428956.2 CDS FTA_1525 NC_009749.1 1365908 1366726 R hypothetical protein complement(1365908..1366726) Francisella tularensis subsp. holarctica FTNF002-00 5524626 YP_001428957.1 CDS FTA_1526 NC_009749.1 1366714 1367043 R hypothetical protein complement(1366714..1367043) Francisella tularensis subsp. holarctica FTNF002-00 5524627 YP_001428959.1 CDS FTA_1528 NC_009749.1 1368295 1368996 D transposase ISFTu2 1368295..1368996 Francisella tularensis subsp. holarctica FTNF002-00 5524629 YP_001428960.1 CDS FTA_1529 NC_009749.1 1369021 1369803 R hypothetical protein complement(1369021..1369803) Francisella tularensis subsp. holarctica FTNF002-00 5524630 YP_001428961.1 CDS FTA_1530 NC_009749.1 1370089 1370802 D hypothetical protein 1370089..1370802 Francisella tularensis subsp. holarctica FTNF002-00 5524631 YP_001428962.2 CDS FTA_1531 NC_009749.1 1370792 1371061 D hypothetical protein 1370792..1371061 Francisella tularensis subsp. holarctica FTNF002-00 5524632 YP_001428963.1 CDS FTA_1532 NC_009749.1 1371518 1372357 D transposase ISFTu2 1371518..1372357 Francisella tularensis subsp. holarctica FTNF002-00 5524633 YP_001428964.2 CDS FTA_1533 NC_009749.1 1372141 1372967 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1372141..1372638,1372638..1372967)) Francisella tularensis subsp. holarctica FTNF002-00 5524634 YP_001428965.1 CDS FTA_1534 NC_009749.1 1373045 1373419 R hypothetical protein complement(1373045..1373419) Francisella tularensis subsp. holarctica FTNF002-00 5524635 YP_001428966.1 CDS uvrC NC_009749.1 1373486 1375324 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(1373486..1375324) Francisella tularensis subsp. holarctica FTNF002-00 5524419 YP_001428967.1 CDS FTA_1536 NC_009749.1 1375433 1376524 D ribonuclease D 1375433..1376524 Francisella tularensis subsp. holarctica FTNF002-00 5524420 YP_001428968.1 CDS FTA_1538 NC_009749.1 1376553 1377767 D Bcr/CflA subfamily drug resistance transporter 1376553..1377767 Francisella tularensis subsp. holarctica FTNF002-00 5524421 YP_001428969.1 CDS FTA_1537 NC_009749.1 1377764 1378141 R hypothetical protein complement(1377764..1378141) Francisella tularensis subsp. holarctica FTNF002-00 5524423 YP_001428970.1 CDS rpmA NC_009749.1 1378528 1378782 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(1378528..1378782) Francisella tularensis subsp. holarctica FTNF002-00 5524422 YP_001428971.1 CDS rplU NC_009749.1 1378813 1379127 R 50S ribosomal protein L21 complement(1378813..1379127) Francisella tularensis subsp. holarctica FTNF002-00 5524424 YP_001428976.1 CDS secA NC_009749.1 1381187 1383907 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1381187..1383907) Francisella tularensis subsp. holarctica FTNF002-00 5524429 YP_001428977.2 CDS FTA_1546 NC_009749.1 1384039 1385067 D hypothetical protein 1384039..1385067 Francisella tularensis subsp. holarctica FTNF002-00 5524430 YP_001428978.1 CDS FTA_1548 NC_009749.1 1385071 1385520 D hypothetical protein 1385071..1385520 Francisella tularensis subsp. holarctica FTNF002-00 5524431 YP_001428979.1 CDS deoD NC_009749.1 1385517 1386239 R purine nucleoside phosphorylase complement(1385517..1386239) Francisella tularensis subsp. holarctica FTNF002-00 5524433 YP_001428980.2 CDS FTA_1549 NC_009749.1 1386312 1387192 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1386312..1386863,1386863..1387192)) Francisella tularensis subsp. holarctica FTNF002-00 5524432 YP_001428982.1 CDS FTA_1551 NC_009749.1 1387470 1388126 D transposase ISFTu2 1387470..1388126 Francisella tularensis subsp. holarctica FTNF002-00 5523905 YP_001428983.1 CDS FTA_1552 NC_009749.1 1388220 1390166 R ATP-dependent metallopeptidase family protein complement(1388220..1390166) Francisella tularensis subsp. holarctica FTNF002-00 5523906 YP_001428986.1 CDS FTA_1555 NC_009749.1 1391384 1392049 D transposase ISFTu2 1391384..1392049 Francisella tularensis subsp. holarctica FTNF002-00 5523909 YP_001428989.1 CDS uvrA NC_009749.1 1392626 1395448 R excinuclease ABC subunit A complement(1392626..1395448) Francisella tularensis subsp. holarctica FTNF002-00 5523912 YP_001428990.1 CDS greA NC_009749.1 1395487 1395969 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1395487..1395969) Francisella tularensis subsp. holarctica FTNF002-00 5523913 YP_001428991.1 CDS FTA_1560 NC_009749.1 1396003 1396587 R prepilin-type N-terminal cleavage/methylation domain-containing protein complement(1396003..1396587) Francisella tularensis subsp. holarctica FTNF002-00 5523914 YP_001428992.1 CDS pgi NC_009749.1 1396588 1398210 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1396588..1398210) Francisella tularensis subsp. holarctica FTNF002-00 5523915 YP_001428993.1 CDS FTA_1562 NC_009749.1 1398197 1398850 R thiamine pyrophosphokinase complement(1398197..1398850) Francisella tularensis subsp. holarctica FTNF002-00 5523916 YP_001428994.1 CDS guaB NC_009749.1 1398916 1400376 R inosine-5'-monophosphate dehydrogenase complement(1398916..1400376) Francisella tularensis subsp. holarctica FTNF002-00 5523917 YP_001428995.1 CDS FTA_1564 NC_009749.1 1400477 1401916 R cytosol aminopeptidase complement(1400477..1401916) Francisella tularensis subsp. holarctica FTNF002-00 5523918 YP_001428996.1 CDS FTA_1565 NC_009749.1 1402082 1403164 D putative permease, YjgP/YjgQ family protein 1402082..1403164 Francisella tularensis subsp. holarctica FTNF002-00 5523157 YP_001428997.2 CDS FTA_1566 NC_009749.1 1403164 1404225 D putative permease YjgP/YjgQ family protein 1403164..1404225 Francisella tularensis subsp. holarctica FTNF002-00 5523158 YP_001428998.1 CDS FTA_1567 NC_009749.1 1404233 1405486 D peptidase M16 family protein 1404233..1405486 Francisella tularensis subsp. holarctica FTNF002-00 5523159 YP_001428999.2 CDS FTA_1568 NC_009749.1 1405493 1406716 D peptidase M16 family protein 1405493..1406716 Francisella tularensis subsp. holarctica FTNF002-00 5523160 YP_001429000.2 CDS FTA_1569 NC_009749.1 1406717 1407295 D methyltransferase family protein 1406717..1407295 Francisella tularensis subsp. holarctica FTNF002-00 5523161 YP_001429001.1 CDS FTA_1570 NC_009749.1 1407329 1407979 D hypothetical protein 1407329..1407979 Francisella tularensis subsp. holarctica FTNF002-00 5523162 YP_001429002.1 CDS FTA_1571 NC_009749.1 1408032 1408643 R tRNA-(ms(2)io(6)a)-hydroxylase complement(1408032..1408643) Francisella tularensis subsp. holarctica FTNF002-00 5523163 YP_001429003.1 CDS FTA_1572 NC_009749.1 1408759 1409562 D uridine phosphorylase 1408759..1409562 Francisella tularensis subsp. holarctica FTNF002-00 5523164 YP_001429004.1 CDS cdd NC_009749.1 1409583 1409984 D cytidine deaminase 1409583..1409984 Francisella tularensis subsp. holarctica FTNF002-00 5523165 YP_001429005.1 CDS FTA_1574 NC_009749.1 1410176 1413211 R FAD-binding domain-containing protein complement(1410176..1413211) Francisella tularensis subsp. holarctica FTNF002-00 5524403 YP_001429006.2 CDS gpmI NC_009749.1 1413418 1414968 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 1413418..1414968 Francisella tularensis subsp. holarctica FTNF002-00 5523167 YP_001429007.1 CDS serS NC_009749.1 1414983 1416263 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1414983..1416263 Francisella tularensis subsp. holarctica FTNF002-00 5523168 YP_001429008.1 CDS FTA_1577 NC_009749.1 1416373 1417272 D ROK (repressor, ORF, kinase) family protein 1416373..1417272 Francisella tularensis subsp. holarctica FTNF002-00 5523169 YP_001429009.1 CDS FTA_1578 NC_009749.1 1417350 1418609 D polysaccharide biosynthesis protein 1417350..1418609 Francisella tularensis subsp. holarctica FTNF002-00 5523170 YP_001429010.1 CDS FTA_1579 NC_009749.1 1418841 1419350 R hypothetical protein complement(1418841..1419350) Francisella tularensis subsp. holarctica FTNF002-00 5523171 YP_001429011.1 CDS FTA_1580 NC_009749.1 1419727 1421508 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1419727..1421508 Francisella tularensis subsp. holarctica FTNF002-00 5523013 YP_001429012.1 CDS FTA_1581 NC_009749.1 1421505 1423154 D in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 1421505..1423154 Francisella tularensis subsp. holarctica FTNF002-00 5523014 YP_001429013.1 CDS FTA_1582 NC_009749.1 1423156 1424406 R C4-dicarboxylate transport protein complement(1423156..1424406) Francisella tularensis subsp. holarctica FTNF002-00 5523015 YP_001429014.1 CDS FTA_1583 NC_009749.1 1424545 1424925 R endoribonuclease L-PSP complement(1424545..1424925) Francisella tularensis subsp. holarctica FTNF002-00 5523016 YP_001429015.1 CDS FTA_1584 NC_009749.1 1424925 1426469 R sulfate permease family protein complement(1424925..1426469) Francisella tularensis subsp. holarctica FTNF002-00 5523017 YP_001429016.1 CDS FTA_1585 NC_009749.1 1426508 1427206 R transposase ISFTu2 complement(1426508..1427206) Francisella tularensis subsp. holarctica FTNF002-00 5523018 YP_001429017.2 CDS FTA_1587 NC_009749.1 1427455 1428678 D major facilitator transporter 1427455..1428678 Francisella tularensis subsp. holarctica FTNF002-00 5523019 YP_001429018.1 CDS FTA_1586 NC_009749.1 1428662 1429987 R deoxyguanosinetriphosphate (dGTP) triphosphohydrolase complement(1428662..1429987) Francisella tularensis subsp. holarctica FTNF002-00 5523021 YP_001429019.1 CDS katG NC_009749.1 1430091 1432316 R catalase/peroxidase HPI complement(1430091..1432316) Francisella tularensis subsp. holarctica FTNF002-00 5523020 YP_001429020.2 CDS FTA_1589 NC_009749.1 1433085 1433965 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1433085..1433636,1433636..1433965)) Francisella tularensis subsp. holarctica FTNF002-00 5523022 YP_001429025.1 CDS FTA_1594 NC_009749.1 1436457 1437773 R glycerol-3-phosphate transporter protein complement(1436457..1437773) Francisella tularensis subsp. holarctica FTNF002-00 5523027 YP_001429026.2 CDS FTA_1595 NC_009749.1 1437880 1438914 R glycerophosphoryl diester phosphodiesterase family protein complement(1437880..1438914) Francisella tularensis subsp. holarctica FTNF002-00 5523330 YP_001429028.1 CDS FTA_1597 NC_009749.1 1440016 1440948 D ABC transporter ATP-binding protein 1440016..1440948 Francisella tularensis subsp. holarctica FTNF002-00 5523332 YP_001429031.1 CDS FTA_1600 NC_009749.1 1442278 1442928 D transposase ISFTu2 1442278..1442928 Francisella tularensis subsp. holarctica FTNF002-00 5523335 YP_001429032.1 CDS FTA_1601 NC_009749.1 1442945 1443289 R hypothetical protein complement(1442945..1443289) Francisella tularensis subsp. holarctica FTNF002-00 5523336 YP_001429035.2 CDS upp NC_009749.1 1444297 1444941 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(1444297..1444941) Francisella tularensis subsp. holarctica FTNF002-00 5523339 YP_001429036.2 CDS FTA_1605 NC_009749.1 1445118 1447442 R glycosyl hydrolase family protein complement(1445118..1447442) Francisella tularensis subsp. holarctica FTNF002-00 5523340 YP_001429037.1 CDS kbl NC_009749.1 1447916 1449130 D catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1447916..1449130 Francisella tularensis subsp. holarctica FTNF002-00 5523341 YP_001429038.1 CDS tdh NC_009749.1 1449153 1450208 D converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1449153..1450208 Francisella tularensis subsp. holarctica FTNF002-00 5523342 YP_001429039.1 CDS FTA_1608 NC_009749.1 1450210 1451472 D hypothetical protein 1450210..1451472 Francisella tularensis subsp. holarctica FTNF002-00 5523343 YP_001429040.1 CDS ispD NC_009749.1 1451477 1452166 R 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1451477..1452166) Francisella tularensis subsp. holarctica FTNF002-00 5523344 YP_001429041.1 CDS FTA_1610 NC_009749.1 1452156 1452446 R putative septum formation initiator protein complement(1452156..1452446) Francisella tularensis subsp. holarctica FTNF002-00 5522831 YP_001429042.1 CDS eno NC_009749.1 1452454 1453824 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(1452454..1453824) Francisella tularensis subsp. holarctica FTNF002-00 5522832 YP_001429043.1 CDS FTA_1612 NC_009749.1 1453933 1455186 R major facilitator transporter complement(1453933..1455186) Francisella tularensis subsp. holarctica FTNF002-00 5522833 YP_001429044.1 CDS FTA_1613 NC_009749.1 1455274 1455831 R nicotinamide mononucleotide transport (NMT) family protein complement(1455274..1455831) Francisella tularensis subsp. holarctica FTNF002-00 5522834 YP_001429045.1 CDS FTA_1614 NC_009749.1 1456151 1456786 R putative ROK family protein complement(1456151..1456786) Francisella tularensis subsp. holarctica FTNF002-00 5522835 YP_001429046.1 CDS rumA NC_009749.1 1456796 1458145 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(1456796..1458145) Francisella tularensis subsp. holarctica FTNF002-00 5522836 YP_001429047.1 CDS FTA_1616 NC_009749.1 1458234 1458806 R hypothetical protein complement(1458234..1458806) Francisella tularensis subsp. holarctica FTNF002-00 5522837 YP_001429048.1 CDS rpoZ NC_009749.1 1459070 1459288 R DNA-directed RNA polymerase subunit omega complement(1459070..1459288) Francisella tularensis subsp. holarctica FTNF002-00 5524261 YP_001429049.1 CDS udk NC_009749.1 1459281 1459946 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1459281..1459946) Francisella tularensis subsp. holarctica FTNF002-00 5522839 YP_001429050.2 CDS kdsA NC_009749.1 1459957 1460805 R catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase complement(1459957..1460805) Francisella tularensis subsp. holarctica FTNF002-00 5522840 YP_001429051.1 CDS FTA_1620 NC_009749.1 1460815 1461165 R essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA complement(1460815..1461165) Francisella tularensis subsp. holarctica FTNF002-00 5522841 YP_001429052.1 CDS FTA_1621 NC_009749.1 1461171 1463252 R polynucleotide phosphorylase/polyadenylase complement(1461171..1463252) Francisella tularensis subsp. holarctica FTNF002-00 5522842 YP_001429053.1 CDS rpsO NC_009749.1 1463309 1463575 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1463309..1463575) Francisella tularensis subsp. holarctica FTNF002-00 5522843 YP_001429054.2 CDS FTA_1623 NC_009749.1 1463681 1465375 R penicillin-binding domain-containing protein complement(1463681..1465375) Francisella tularensis subsp. holarctica FTNF002-00 5522844 YP_001429055.2 CDS FTA_1624 NC_009749.1 1465368 1465718 R cell division protein FtsL complement(1465368..1465718) Francisella tularensis subsp. holarctica FTNF002-00 5522845 YP_001429056.2 CDS mraW NC_009749.1 1465715 1466632 R S-adenosyl-methyltransferase MraW complement(1465715..1466632) Francisella tularensis subsp. holarctica FTNF002-00 5522755 YP_001429057.1 CDS FTA_1626 NC_009749.1 1466638 1468737 R AMP-binding domain-containing protein complement(1466638..1468737) Francisella tularensis subsp. holarctica FTNF002-00 5522756 YP_001429058.1 CDS mutM NC_009749.1 1468830 1469654 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 1468830..1469654 Francisella tularensis subsp. holarctica FTNF002-00 5522757 YP_001429059.2 CDS FTA_1628 NC_009749.1 1469725 1470605 D programmed ribosomal frameshift; transposase ISFtu1 join(1469725..1470054,1470054..1470605) Francisella tularensis subsp. holarctica FTNF002-00 5522758 YP_001429061.2 CDS FTA_1630 NC_009749.1 1470613 1471161 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1470613..1471161) Francisella tularensis subsp. holarctica FTNF002-00 5522760 YP_001429062.1 CDS FTA_1631 NC_009749.1 1471155 1472018 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1471155..1472018) Francisella tularensis subsp. holarctica FTNF002-00 5522761 YP_001429063.2 CDS gyrB NC_009749.1 1472148 1474565 R DNA gyrase subunit B complement(1472148..1474565) Francisella tularensis subsp. holarctica FTNF002-00 5522762 YP_001429064.1 CDS FTA_1633 NC_009749.1 1474609 1474731 R hypothetical protein complement(1474609..1474731) Francisella tularensis subsp. holarctica FTNF002-00 5522763 YP_001429065.2 CDS FTA_1634 NC_009749.1 1474741 1475541 D hypothetical protein 1474741..1475541 Francisella tularensis subsp. holarctica FTNF002-00 5522764 YP_001429066.2 CDS FTA_1635 NC_009749.1 1475575 1476558 D tRNA-dihydrouridine synthase A 1475575..1476558 Francisella tularensis subsp. holarctica FTNF002-00 5522765 YP_001429067.1 CDS FTA_1636 NC_009749.1 1476565 1477332 R putative lipoprotein complement(1476565..1477332) Francisella tularensis subsp. holarctica FTNF002-00 5522766 YP_001429068.1 CDS FTA_1637 NC_009749.1 1478000 1478314 D hypothetical protein 1478000..1478314 Francisella tularensis subsp. holarctica FTNF002-00 5522767 YP_001429069.1 CDS FTA_1638 NC_009749.1 1478322 1480235 R hypothetical protein complement(1478322..1480235) Francisella tularensis subsp. holarctica FTNF002-00 5522768 YP_001429070.1 CDS sucC NC_009749.1 1480405 1481568 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1480405..1481568 Francisella tularensis subsp. holarctica FTNF002-00 5522769 YP_001429071.1 CDS FTA_1640 NC_009749.1 1481600 1482472 D succinyl-CoA synthetase alpha chain 1481600..1482472 Francisella tularensis subsp. holarctica FTNF002-00 5522671 YP_001429072.1 CDS FTA_1641 NC_009749.1 1482582 1483007 D hypothetical protein 1482582..1483007 Francisella tularensis subsp. holarctica FTNF002-00 5522672 YP_001429079.1 CDS FTA_1648 NC_009749.1 1487454 1488374 D asparaginase 1487454..1488374 Francisella tularensis subsp. holarctica FTNF002-00 5522679 YP_001429082.1 CDS FTA_1651 NC_009749.1 1489984 1490706 D copper transport (CutC) family protein 1489984..1490706 Francisella tularensis subsp. holarctica FTNF002-00 5522682 YP_001429083.1 CDS FTA_1652 NC_009749.1 1490721 1491887 R major facilitator transporter complement(1490721..1491887) Francisella tularensis subsp. holarctica FTNF002-00 5522683 YP_001429084.1 CDS FTA_1653 NC_009749.1 1491998 1492924 D LysR family transcriptional regulator 1491998..1492924 Francisella tularensis subsp. holarctica FTNF002-00 5522684 YP_001429085.2 CDS FTA_1654 NC_009749.1 1492965 1493639 D putative phosphoglycolate phosphatase 1492965..1493639 Francisella tularensis subsp. holarctica FTNF002-00 5522685 YP_001715627.1 CDS FTA_2151 NC_009749.1 1494754 1494891 D hypothetical protein 1494754..1494891 Francisella tularensis subsp. holarctica FTNF002-00 5983833 YP_001429087.1 CDS trxB NC_009749.1 1494983 1495933 D thioredoxin reductase 1494983..1495933 Francisella tularensis subsp. holarctica FTNF002-00 5522657 YP_001429088.1 CDS FTA_1657 NC_009749.1 1496202 1496888 D transposase ISFTu2 1496202..1496888 Francisella tularensis subsp. holarctica FTNF002-00 5522658 YP_001429092.1 CDS FTA_1661 NC_009749.1 1499157 1500959 R DNA mismatch repair protein complement(1499157..1500959) Francisella tularensis subsp. holarctica FTNF002-00 5522662 YP_001429095.1 CDS FTA_1664 NC_009749.1 1501698 1502417 R hypothetical protein complement(1501698..1502417) Francisella tularensis subsp. holarctica FTNF002-00 5522665 YP_001429096.1 CDS rsgA NC_009749.1 1502571 1503458 D ribosome small subunit-dependent GTPase A 1502571..1503458 Francisella tularensis subsp. holarctica FTNF002-00 5522666 YP_001429097.1 CDS FTA_1666 NC_009749.1 1503677 1504492 D putative lipoprotein 1503677..1504492 Francisella tularensis subsp. holarctica FTNF002-00 5522667 YP_001429098.2 CDS FTA_1667 NC_009749.1 1504745 1505926 R hypothetical protein complement(1504745..1505926) Francisella tularensis subsp. holarctica FTNF002-00 5522668 YP_001429099.1 CDS FTA_1668 NC_009749.1 1506010 1507419 D amino acid permease 1506010..1507419 Francisella tularensis subsp. holarctica FTNF002-00 5522669 YP_001429100.1 CDS FTA_1669 NC_009749.1 1507521 1508627 D PerM family protein 1507521..1508627 Francisella tularensis subsp. holarctica FTNF002-00 5522670 YP_001429101.1 CDS recJ NC_009749.1 1508621 1510363 D single-stranded-DNA-specific exonuclease RecJ 1508621..1510363 Francisella tularensis subsp. holarctica FTNF002-00 5524606 YP_001429102.1 CDS FTA_1671 NC_009749.1 1510360 1511142 D biotin--acetyl-CoA-carboxylase ligase 1510360..1511142 Francisella tularensis subsp. holarctica FTNF002-00 5524607 YP_001429103.1 CDS FTA_1672 NC_009749.1 1511139 1512062 D tRNA synthetases class II protein 1511139..1512062 Francisella tularensis subsp. holarctica FTNF002-00 5524608 YP_001429105.1 CDS FTA_1674 NC_009749.1 1512772 1513530 R transposase ISFTu2 complement(1512772..1513530) Francisella tularensis subsp. holarctica FTNF002-00 5524610 YP_001429107.1 CDS FTA_1676 NC_009749.1 1514091 1514771 R hypothetical protein complement(1514091..1514771) Francisella tularensis subsp. holarctica FTNF002-00 5524612 YP_001429108.1 CDS accC NC_009749.1 1514865 1516220 R acetyl-CoA carboxylase, biotin carboxylase complement(1514865..1516220) Francisella tularensis subsp. holarctica FTNF002-00 5524613 YP_001429109.1 CDS accB NC_009749.1 1516285 1516758 R acetyl-CoA carboxylase, biotin carboxyl carrier protein complement(1516285..1516758) Francisella tularensis subsp. holarctica FTNF002-00 5524614 YP_001429110.1 CDS FTA_1679 NC_009749.1 1516763 1517200 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(1516763..1517200) Francisella tularensis subsp. holarctica FTNF002-00 5524615 YP_001429111.1 CDS apaH NC_009749.1 1517204 1518031 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(1517204..1518031) Francisella tularensis subsp. holarctica FTNF002-00 5524616 YP_001429112.1 CDS ksgA NC_009749.1 1518043 1518831 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1518043..1518831) Francisella tularensis subsp. holarctica FTNF002-00 5524617 YP_001429113.2 CDS FTA_1682 NC_009749.1 1518833 1520260 R hypothetical protein complement(1518833..1520260) Francisella tularensis subsp. holarctica FTNF002-00 5524618 YP_001429114.1 CDS FTA_1683 NC_009749.1 1520242 1522848 R organic solvent tolerance protein complement(1520242..1522848) Francisella tularensis subsp. holarctica FTNF002-00 5524619 YP_001429115.1 CDS argS NC_009749.1 1522974 1524719 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1522974..1524719 Francisella tularensis subsp. holarctica FTNF002-00 5524620 YP_001429118.1 CDS FTA_1687 NC_009749.1 1526757 1527224 R tRNA/rRNA methyltransferase complement(1526757..1527224) Francisella tularensis subsp. holarctica FTNF002-00 5522963 YP_001429119.1 CDS hemB NC_009749.1 1527228 1528202 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(1527228..1528202) Francisella tularensis subsp. holarctica FTNF002-00 5522964 YP_001429120.1 CDS FTA_1689 NC_009749.1 1528210 1528488 R CRS1/YhbY domain, RNA-binding protein complement(1528210..1528488) Francisella tularensis subsp. holarctica FTNF002-00 5522965 YP_001429121.1 CDS FTA_1690 NC_009749.1 1528499 1529410 R DNA polymerase III subunit delta' complement(1528499..1529410) Francisella tularensis subsp. holarctica FTNF002-00 5522966 YP_001429122.1 CDS FTA_1691 NC_009749.1 1529418 1530434 R SohB; periplasmic protein; member of the peptidase S49 family; putative periplasmic protease complement(1529418..1530434) Francisella tularensis subsp. holarctica FTNF002-00 5522967 YP_001429123.2 CDS FTA_1692 NC_009749.1 1530446 1531078 R glutathione S-transferase domain-containing protein complement(1530446..1531078) Francisella tularensis subsp. holarctica FTNF002-00 5522968 YP_001429124.2 CDS FTA_1693 NC_009749.1 1531164 1531478 D DsrC (dissimilatory sulfite reductase)-like protein 1531164..1531478 Francisella tularensis subsp. holarctica FTNF002-00 5522969 YP_001429125.2 CDS FTA_1694 NC_009749.1 1531469 1531762 D hypothetical protein 1531469..1531762 Francisella tularensis subsp. holarctica FTNF002-00 5522970 YP_001429126.1 CDS FTA_1695 NC_009749.1 1531854 1533614 D dolichyl-phosphate-mannose-protein mannosyltransferase family protein 1531854..1533614 Francisella tularensis subsp. holarctica FTNF002-00 5522971 YP_001429127.2 CDS FTA_1696 NC_009749.1 1533899 1534779 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1533899..1534450,1534450..1534779)) Francisella tularensis subsp. holarctica FTNF002-00 5522972 YP_001429129.2 CDS FTA_1698 NC_009749.1 1534770 1534928 D hypothetical protein 1534770..1534928 Francisella tularensis subsp. holarctica FTNF002-00 5522974 YP_001429130.2 CDS FTA_1699 NC_009749.1 1534938 1535894 R glycosyl transferase family protein complement(1534938..1535894) Francisella tularensis subsp. holarctica FTNF002-00 5522975 YP_001429131.1 CDS FTA_1700 NC_009749.1 1535993 1536799 D hypothetical protein 1535993..1536799 Francisella tularensis subsp. holarctica FTNF002-00 5522984 YP_001429132.2 CDS ftsW NC_009749.1 1536807 1538012 R cell division protein FtsW complement(1536807..1538012) Francisella tularensis subsp. holarctica FTNF002-00 5522985 YP_001429133.1 CDS murD NC_009749.1 1538022 1539272 R UDP-N-acetylmuramoylalanine--D-glutamate ligase complement(1538022..1539272) Francisella tularensis subsp. holarctica FTNF002-00 5522986 YP_001429134.1 CDS mraY NC_009749.1 1539272 1540369 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1539272..1540369) Francisella tularensis subsp. holarctica FTNF002-00 5522987 YP_001429135.2 CDS pckA NC_009749.1 1540444 1542036 R PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase complement(1540444..1542036) Francisella tularensis subsp. holarctica FTNF002-00 5522988 YP_001429136.1 CDS glnS NC_009749.1 1542181 1543827 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 1542181..1543827 Francisella tularensis subsp. holarctica FTNF002-00 5522989 YP_001429140.2 CDS FTA_1709 NC_009749.1 1545332 1545820 R hypothetical protein complement(1545332..1545820) Francisella tularensis subsp. holarctica FTNF002-00 5522993 YP_001429141.1 CDS FTA_1710 NC_009749.1 1545877 1547718 R ABC transporter ATP-binding protein complement(1545877..1547718) Francisella tularensis subsp. holarctica FTNF002-00 5522994 YP_001429142.2 CDS FTA_1711 NC_009749.1 1547752 1548978 R major facilitator transporter complement(1547752..1548978) Francisella tularensis subsp. holarctica FTNF002-00 5522995 YP_001429143.1 CDS FTA_1712 NC_009749.1 1549061 1550104 R hypothetical protein complement(1549061..1550104) Francisella tularensis subsp. holarctica FTNF002-00 5522996 YP_001429145.1 CDS FTA_1714 NC_009749.1 1551579 1552223 D hypothetical protein 1551579..1552223 Francisella tularensis subsp. holarctica FTNF002-00 5522998 YP_001429146.2 CDS FTA_1715 NC_009749.1 1552239 1552430 R hypothetical protein complement(1552239..1552430) Francisella tularensis subsp. holarctica FTNF002-00 5523660 YP_001429147.2 CDS FTA_1716 NC_009749.1 1552421 1553301 D programmed ribosomal frameshift; transposase ISFtu1 join(1552421..1552750,1552750..1553301) Francisella tularensis subsp. holarctica FTNF002-00 5523661 YP_001429152.2 CDS FTA_1721 NC_009749.1 1555899 1556779 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1555899..1556450,1556450..1556779)) Francisella tularensis subsp. holarctica FTNF002-00 5523666 YP_001429154.1 CDS FTA_1723 NC_009749.1 1556841 1557875 R hypothetical protein complement(1556841..1557875) Francisella tularensis subsp. holarctica FTNF002-00 5523668 YP_001429156.1 CDS FTA_1725 NC_009749.1 1558209 1558934 R hypothetical protein complement(1558209..1558934) Francisella tularensis subsp. holarctica FTNF002-00 5523670 YP_001429157.2 CDS FTA_1726 NC_009749.1 1559115 1560107 R LysR family transcriptional regulator complement(1559115..1560107) Francisella tularensis subsp. holarctica FTNF002-00 5523671 YP_001429161.1 CDS FTA_1730 NC_009749.1 1563683 1563844 D hypothetical protein 1563683..1563844 Francisella tularensis subsp. holarctica FTNF002-00 5523830 YP_001429163.1 CDS ubiG NC_009749.1 1565277 1565972 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 1565277..1565972 Francisella tularensis subsp. holarctica FTNF002-00 5523832 YP_001429164.1 CDS FTA_1733 NC_009749.1 1565975 1566718 D hypothetical protein 1565975..1566718 Francisella tularensis subsp. holarctica FTNF002-00 5523833 YP_001429165.1 CDS FTA_1734 NC_009749.1 1566715 1566951 D hypothetical protein 1566715..1566951 Francisella tularensis subsp. holarctica FTNF002-00 5523834 YP_001429166.2 CDS FTA_1735 NC_009749.1 1567084 1568586 D amino acid permease 1567084..1568586 Francisella tularensis subsp. holarctica FTNF002-00 5523835 YP_001429167.1 CDS FTA_1736 NC_009749.1 1568599 1568880 D hypothetical protein 1568599..1568880 Francisella tularensis subsp. holarctica FTNF002-00 5523836 YP_001429168.2 CDS FTA_1737 NC_009749.1 1568894 1569133 R hypothetical protein complement(1568894..1569133) Francisella tularensis subsp. holarctica FTNF002-00 5523837 YP_001429169.2 CDS FTA_1738 NC_009749.1 1569124 1570004 D programmed ribosomal frameshift; transposase ISFtu1 join(1569124..1569453,1569453..1570004) Francisella tularensis subsp. holarctica FTNF002-00 5523838 YP_001429171.1 CDS glpK NC_009749.1 1570001 1571509 R glycerol kinase complement(1570001..1571509) Francisella tularensis subsp. holarctica FTNF002-00 5523841 YP_001429172.1 CDS FTA_1741 NC_009749.1 1571577 1572788 R major facilitator transporter complement(1571577..1572788) Francisella tularensis subsp. holarctica FTNF002-00 5523840 YP_001429173.1 CDS FTA_1742 NC_009749.1 1572802 1572927 D hypothetical protein 1572802..1572927 Francisella tularensis subsp. holarctica FTNF002-00 5523842 YP_001429174.1 CDS FTA_1743 NC_009749.1 1572948 1573559 R hypothetical protein complement(1572948..1573559) Francisella tularensis subsp. holarctica FTNF002-00 5523843 YP_001429175.2 CDS FTA_1744 NC_009749.1 1573693 1574895 D major facilitator transporter 1573693..1574895 Francisella tularensis subsp. holarctica FTNF002-00 5523844 YP_001429176.1 CDS FTA_1745 NC_009749.1 1575064 1575867 R ABC transporter ATP-binding protein complement(1575064..1575867) Francisella tularensis subsp. holarctica FTNF002-00 5524494 YP_001429183.1 CDS FTA_1752 NC_009749.1 1579403 1580053 R transposase ISFTu2 complement(1579403..1580053) Francisella tularensis subsp. holarctica FTNF002-00 5524501 YP_001429184.1 CDS FTA_1753 NC_009749.1 1580317 1582539 R DNA helicase II complement(1580317..1582539) Francisella tularensis subsp. holarctica FTNF002-00 5524502 YP_001429185.2 CDS ftsY NC_009749.1 1582630 1583661 R signal recognition particle-docking protein FtsY complement(1582630..1583661) Francisella tularensis subsp. holarctica FTNF002-00 5524503 YP_001429186.1 CDS FTA_1755 NC_009749.1 1583658 1584974 R LysM domain-containing protein complement(1583658..1584974) Francisella tularensis subsp. holarctica FTNF002-00 5524504 YP_001429187.1 CDS prfC NC_009749.1 1585049 1586626 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(1585049..1586626) Francisella tularensis subsp. holarctica FTNF002-00 5524505 YP_001429188.1 CDS tmk NC_009749.1 1586688 1587317 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(1586688..1587317) Francisella tularensis subsp. holarctica FTNF002-00 5524506 YP_001429189.1 CDS FTA_1758 NC_009749.1 1587330 1588532 R nucleoside permease, NupC family protein complement(1587330..1588532) Francisella tularensis subsp. holarctica FTNF002-00 5524507 YP_001429190.1 CDS FTA_1759 NC_009749.1 1588551 1589750 R nucleoside permease, NupC family protein complement(1588551..1589750) Francisella tularensis subsp. holarctica FTNF002-00 5524508 YP_001429191.2 CDS deoC NC_009749.1 1589740 1590501 R deoxyribose-phosphate aldolase complement(1589740..1590501) Francisella tularensis subsp. holarctica FTNF002-00 5524000 YP_001429192.1 CDS deoB NC_009749.1 1590464 1591708 R catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase complement(1590464..1591708) Francisella tularensis subsp. holarctica FTNF002-00 5524001 YP_001429193.1 CDS FTA_1762 NC_009749.1 1591713 1592477 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(1591713..1592477) Francisella tularensis subsp. holarctica FTNF002-00 5524002 YP_001429194.1 CDS polA NC_009749.1 1592497 1595190 R DNA polymerase I complement(1592497..1595190) Francisella tularensis subsp. holarctica FTNF002-00 5524003 YP_001429195.2 CDS lpxK NC_009749.1 1595286 1596254 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(1595286..1596254) Francisella tularensis subsp. holarctica FTNF002-00 5524004 YP_001429197.1 CDS FTA_1766 NC_009749.1 1598194 1599276 D catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1598194..1599276 Francisella tularensis subsp. holarctica FTNF002-00 5524006 YP_001429198.1 CDS FTA_1767 NC_009749.1 1599316 1599807 D disulfide bond formation protein 1599316..1599807 Francisella tularensis subsp. holarctica FTNF002-00 5524007 YP_001429199.1 CDS FTA_1768 NC_009749.1 1599820 1601193 D MFP (membrane fusion protein) subunit, RND family protein 1599820..1601193 Francisella tularensis subsp. holarctica FTNF002-00 5524008 YP_001429200.1 CDS FTA_1769 NC_009749.1 1601193 1604306 D RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein 1601193..1604306 Francisella tularensis subsp. holarctica FTNF002-00 5524009 YP_001429201.2 CDS FTA_1770 NC_009749.1 1604438 1605718 D major facilitator transporter 1604438..1605718 Francisella tularensis subsp. holarctica FTNF002-00 5524010 YP_001429202.1 CDS FTA_1771 NC_009749.1 1605963 1606544 D hypothetical protein 1605963..1606544 Francisella tularensis subsp. holarctica FTNF002-00 5524011 YP_001429203.1 CDS FTA_1772 NC_009749.1 1606681 1606809 R hypothetical protein complement(1606681..1606809) Francisella tularensis subsp. holarctica FTNF002-00 5524012 YP_001429206.2 CDS FTA_1775 NC_009749.1 1607989 1609002 R LD-carboxypeptidase family protein complement(1607989..1609002) Francisella tularensis subsp. holarctica FTNF002-00 5522585 YP_001429207.1 CDS FTA_1776 NC_009749.1 1609231 1609584 R IS1016 family transposase complement(1609231..1609584) Francisella tularensis subsp. holarctica FTNF002-00 5522586 YP_001429208.1 CDS FTA_1777 NC_009749.1 1609610 1610290 R transposase ISFTu2 complement(1609610..1610290) Francisella tularensis subsp. holarctica FTNF002-00 5522587 YP_001429209.2 CDS FTA_1778 NC_009749.1 1610568 1611448 D programmed ribosomal frameshift; transposase ISFtu1 join(1610568..1610897,1610897..1611448) Francisella tularensis subsp. holarctica FTNF002-00 5522588 YP_001429212.1 CDS cysS NC_009749.1 1611819 1613213 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1611819..1613213 Francisella tularensis subsp. holarctica FTNF002-00 5522591 YP_001429213.1 CDS FTA_1782 NC_009749.1 1613217 1614161 D involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1613217..1614161 Francisella tularensis subsp. holarctica FTNF002-00 5522592 YP_001429214.1 CDS FTA_1783 NC_009749.1 1614217 1615404 D major facilitator transporter 1614217..1615404 Francisella tularensis subsp. holarctica FTNF002-00 5522593 YP_001429215.2 CDS FTA_1784 NC_009749.1 1615418 1615909 D acetyltransferase 1615418..1615909 Francisella tularensis subsp. holarctica FTNF002-00 5522594 YP_001429216.2 CDS FTA_1785 NC_009749.1 1616055 1616935 D programmed ribosomal frameshift; transposase ISFtu1 join(1616055..1616384,1616384..1616935) Francisella tularensis subsp. holarctica FTNF002-00 5522595 YP_001429218.1 CDS FTA_1787 NC_009749.1 1617248 1618099 R hypothetical protein complement(1617248..1618099) Francisella tularensis subsp. holarctica FTNF002-00 5522597 YP_001429219.1 CDS FTA_1788 NC_009749.1 1618103 1619032 R hypothetical protein complement(1618103..1619032) Francisella tularensis subsp. holarctica FTNF002-00 5522598 YP_001429224.1 CDS FTA_1793 NC_009749.1 1621738 1622541 R prepilin-type N- terminal cleavage/methylation domain-containing protein complement(1621738..1622541) Francisella tularensis subsp. holarctica FTNF002-00 5523117 YP_001429225.2 CDS FTA_1794 NC_009749.1 1622525 1622872 R hypothetical protein complement(1622525..1622872) Francisella tularensis subsp. holarctica FTNF002-00 5523118 YP_001429229.1 CDS FTA_1798 NC_009749.1 1624256 1625935 R glycosyltransferase, group 2 family protein complement(1624256..1625935) Francisella tularensis subsp. holarctica FTNF002-00 5523122 YP_001429231.1 CDS glpX NC_009749.1 1627779 1628765 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(1627779..1628765) Francisella tularensis subsp. holarctica FTNF002-00 5523124 YP_001429232.1 CDS FTA_1801 NC_009749.1 1628785 1629423 R hypothetical protein complement(1628785..1629423) Francisella tularensis subsp. holarctica FTNF002-00 5523125 YP_001429233.2 CDS FTA_1802 NC_009749.1 1629432 1630886 R amino acid permease complement(1629432..1630886) Francisella tularensis subsp. holarctica FTNF002-00 5523126 YP_001429234.2 CDS FTA_1803 NC_009749.1 1631133 1631801 R PAP2 (2 phosphatidic acid phosphatase) family protein complement(1631133..1631801) Francisella tularensis subsp. holarctica FTNF002-00 5523127 YP_001429235.1 CDS FTA_1804 NC_009749.1 1631923 1634424 D cell division protein FtsK 1631923..1634424 Francisella tularensis subsp. holarctica FTNF002-00 5523128 YP_001429236.1 CDS lolA NC_009749.1 1634425 1635042 D lipoprotein releasing system subunit A, outer membrane lipoproteins carrier 1634425..1635042 Francisella tularensis subsp. holarctica FTNF002-00 5524087 YP_001429237.1 CDS FTA_1806 NC_009749.1 1635056 1635187 R hypothetical protein complement(1635056..1635187) Francisella tularensis subsp. holarctica FTNF002-00 5524088 YP_001429238.2 CDS FTA_1807 NC_009749.1 1635436 1635639 R hypothetical protein complement(1635436..1635639) Francisella tularensis subsp. holarctica FTNF002-00 5524089 YP_001429239.2 CDS FTA_1808 NC_009749.1 1635751 1637205 D cation efflux transporter 1635751..1637205 Francisella tularensis subsp. holarctica FTNF002-00 5524090 YP_001429240.2 CDS FTA_1809 NC_009749.1 1637220 1637765 R putative lipoprotein complement(1637220..1637765) Francisella tularensis subsp. holarctica FTNF002-00 5524091 YP_001429241.1 CDS FTA_1810 NC_009749.1 1637788 1638489 R putative activator of osmoprotectant transporter complement(1637788..1638489) Francisella tularensis subsp. holarctica FTNF002-00 5524092 YP_001429242.1 CDS FTA_1811 NC_009749.1 1638509 1638658 R hypothetical protein complement(1638509..1638658) Francisella tularensis subsp. holarctica FTNF002-00 5524093 YP_001429245.2 CDS FTA_1814 NC_009749.1 1640169 1641049 D programmed ribosomal frameshift; transposase ISFtu1 join(1640169..1640498,1640498..1641049) Francisella tularensis subsp. holarctica FTNF002-00 5524096 YP_001429247.2 CDS groEL NC_009749.1 1641169 1642848 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1641169..1642848) Francisella tularensis subsp. holarctica FTNF002-00 5524098 YP_001429248.1 CDS groES NC_009749.1 1642841 1643128 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1642841..1643128) Francisella tularensis subsp. holarctica FTNF002-00 5524099 YP_001429249.2 CDS FTA_1818 NC_009749.1 1643371 1643805 D hypothetical protein 1643371..1643805 Francisella tularensis subsp. holarctica FTNF002-00 5524100 YP_001429250.1 CDS FTA_1819 NC_009749.1 1644416 1645210 D hypothetical protein 1644416..1645210 Francisella tularensis subsp. holarctica FTNF002-00 5524152 YP_001429251.2 CDS FTA_1820 NC_009749.1 1645261 1646141 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1645261..1645812,1645812..1646141)) Francisella tularensis subsp. holarctica FTNF002-00 5522727 YP_001429253.2 CDS FTA_1823 NC_009749.1 1646132 1646632 D hypothetical protein 1646132..1646632 Francisella tularensis subsp. holarctica FTNF002-00 5522729 YP_001429254.1 CDS FTA_1822 NC_009749.1 1646623 1647477 R methyltransferase, HemK family protein complement(1646623..1647477) Francisella tularensis subsp. holarctica FTNF002-00 5522731 YP_001429255.1 CDS prfA NC_009749.1 1647470 1648555 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(1647470..1648555) Francisella tularensis subsp. holarctica FTNF002-00 5522730 YP_001429256.2 CDS hemA NC_009749.1 1648556 1649806 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(1648556..1649806) Francisella tularensis subsp. holarctica FTNF002-00 5522732 YP_001429257.1 CDS FTA_1826 NC_009749.1 1649980 1650618 D hypothetical protein 1649980..1650618 Francisella tularensis subsp. holarctica FTNF002-00 5522733 YP_001429258.1 CDS FTA_1827 NC_009749.1 1650621 1651991 D lipoprotein 1650621..1651991 Francisella tularensis subsp. holarctica FTNF002-00 5522734 YP_001429259.1 CDS FTA_1828 NC_009749.1 1651991 1653172 D Bcr/CflA subfamily drug resistance transporter 1651991..1653172 Francisella tularensis subsp. holarctica FTNF002-00 5522735 YP_001429260.1 CDS parE NC_009749.1 1653262 1655145 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1653262..1655145 Francisella tularensis subsp. holarctica FTNF002-00 5522736 YP_001429261.1 CDS FTA_1830 NC_009749.1 1655193 1655717 R N-acetyl-anhydromuranmyl-L-alanine amidase complement(1655193..1655717) Francisella tularensis subsp. holarctica FTNF002-00 5522737 YP_001429262.1 CDS FTA_1831 NC_009749.1 1655791 1656417 D PAP2 family protein 1655791..1656417 Francisella tularensis subsp. holarctica FTNF002-00 5522738 YP_001429263.1 CDS FTA_1832 NC_009749.1 1656427 1656894 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(1656427..1656894) Francisella tularensis subsp. holarctica FTNF002-00 5522739 YP_001429265.1 CDS FTA_1835 NC_009749.1 1658698 1659582 D licB-like transmembrane protein 1658698..1659582 Francisella tularensis subsp. holarctica FTNF002-00 5522741 YP_001429266.1 CDS FTA_1834 NC_009749.1 1659579 1660163 R HAD superfamily acid phosphatase complement(1659579..1660163) Francisella tularensis subsp. holarctica FTNF002-00 5523603 YP_001429267.2 CDS FTA_1836 NC_009749.1 1660168 1661019 R iron/ascorbate family oxidoreductase complement(1660168..1661019) Francisella tularensis subsp. holarctica FTNF002-00 5523602 YP_001429268.1 CDS xerD NC_009749.1 1661136 1662014 R tyrosine recombinase XerD complement(1661136..1662014) Francisella tularensis subsp. holarctica FTNF002-00 5523604 YP_001429269.1 CDS rplS NC_009749.1 1662180 1662527 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1662180..1662527) Francisella tularensis subsp. holarctica FTNF002-00 5523605 YP_001429270.2 CDS trmD NC_009749.1 1662527 1663291 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(1662527..1663291) Francisella tularensis subsp. holarctica FTNF002-00 5523606 YP_001429271.1 CDS rimM NC_009749.1 1663688 1664197 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(1663688..1664197) Francisella tularensis subsp. holarctica FTNF002-00 5523607 YP_001429272.2 CDS rpsP NC_009749.1 1664240 1664488 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(1664240..1664488) Francisella tularensis subsp. holarctica FTNF002-00 5523608 YP_001429273.1 CDS metK NC_009749.1 1664782 1665942 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1664782..1665942 Francisella tularensis subsp. holarctica FTNF002-00 5523609 YP_001429274.1 CDS FTA_1843 NC_009749.1 1666154 1667320 R fatty acid desaturase complement(1666154..1667320) Francisella tularensis subsp. holarctica FTNF002-00 5523610 YP_001429275.1 CDS FTA_1844 NC_009749.1 1667434 1668444 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease complement(1667434..1668444) Francisella tularensis subsp. holarctica FTNF002-00 5523611 YP_001429276.1 CDS FTA_1845 NC_009749.1 1668444 1668680 R hypothetical protein complement(1668444..1668680) Francisella tularensis subsp. holarctica FTNF002-00 5523612 YP_001429279.1 CDS rpoB NC_009749.1 1673098 1677183 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1673098..1677183) Francisella tularensis subsp. holarctica FTNF002-00 5523615 YP_001429280.1 CDS rplL NC_009749.1 1677328 1677705 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1677328..1677705) Francisella tularensis subsp. holarctica FTNF002-00 5523616 YP_001429281.1 CDS rplJ NC_009749.1 1677767 1678285 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1677767..1678285) Francisella tularensis subsp. holarctica FTNF002-00 5524449 YP_001429282.2 CDS rplA NC_009749.1 1678455 1679153 R in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 complement(1678455..1679153) Francisella tularensis subsp. holarctica FTNF002-00 5524450 YP_001429283.2 CDS rplK NC_009749.1 1679153 1679599 R binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(1679153..1679599) Francisella tularensis subsp. holarctica FTNF002-00 5524451 YP_001429284.2 CDS nusG NC_009749.1 1679656 1680189 R transcription termination/antitermination factor NusG complement(1679656..1680189) Francisella tularensis subsp. holarctica FTNF002-00 5524452 YP_001429285.2 CDS secE NC_009749.1 1680205 1680675 R forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1680205..1680675) Francisella tularensis subsp. holarctica FTNF002-00 5524453 YP_001429286.1 CDS tufA NC_009749.1 1680867 1682051 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1680867..1682051) Francisella tularensis subsp. holarctica FTNF002-00 5524654 YP_001429287.2 CDS FTA_1856 NC_009749.1 1682516 1683763 R hypothetical protein complement(1682516..1683763) Francisella tularensis subsp. holarctica FTNF002-00 5524219 YP_001429288.1 CDS FTA_1857 NC_009749.1 1683930 1684427 R hypothetical protein complement(1683930..1684427) Francisella tularensis subsp. holarctica FTNF002-00 5524456 YP_001429289.1 CDS FTA_1858 NC_009749.1 1684405 1685118 R hypothetical protein complement(1684405..1685118) Francisella tularensis subsp. holarctica FTNF002-00 5524457 YP_001429290.1 CDS FTA_1859 NC_009749.1 1685122 1685886 R major intrinsic protein family permease complement(1685122..1685886) Francisella tularensis subsp. holarctica FTNF002-00 5524458 YP_001429291.1 CDS FTA_1860 NC_009749.1 1685896 1687428 R FAD dependent oxidoreductase complement(1685896..1687428) Francisella tularensis subsp. holarctica FTNF002-00 5524459 YP_001429292.2 CDS FTA_1861 NC_009749.1 1687744 1688624 D programmed ribosomal frameshift; transposase ISFtu1 join(1687744..1688073,1688073..1688624) Francisella tularensis subsp. holarctica FTNF002-00 5524460 YP_001429299.1 CDS FTA_1869 NC_009749.1 1691627 1693054 D histidine kinase domain-containing protein 1691627..1693054 Francisella tularensis subsp. holarctica FTNF002-00 5522772 YP_001429300.1 CDS FTA_1868 NC_009749.1 1693051 1693932 R hypothetical protein complement(1693051..1693932) Francisella tularensis subsp. holarctica FTNF002-00 5522774 YP_001429301.2 CDS FTA_1870 NC_009749.1 1694450 1695544 D cytochrome ubiquinol oxidase 1694450..1695544 Francisella tularensis subsp. holarctica FTNF002-00 5522773 YP_001429302.1 CDS FTA_1871 NC_009749.1 1695548 1696510 D cytochrome bd-type quinol oxidase subunit II 1695548..1696510 Francisella tularensis subsp. holarctica FTNF002-00 5522775 YP_001429303.1 CDS FTA_1872 NC_009749.1 1696521 1696955 D hypothetical protein 1696521..1696955 Francisella tularensis subsp. holarctica FTNF002-00 5522776 YP_001429309.1 CDS acnA NC_009749.1 1699152 1701965 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1699152..1701965) Francisella tularensis subsp. holarctica FTNF002-00 5522782 YP_001429310.1 CDS FTA_1879 NC_009749.1 1702070 1702948 R hypothetical protein complement(1702070..1702948) Francisella tularensis subsp. holarctica FTNF002-00 5522783 YP_001429311.1 CDS FTA_1880 NC_009749.1 1703018 1703395 D hypothetical protein 1703018..1703395 Francisella tularensis subsp. holarctica FTNF002-00 5522784 YP_001429312.2 CDS FTA_1882 NC_009749.1 1703400 1704542 D oxygen-independent coproporphyrinogen III oxidase 1703400..1704542 Francisella tularensis subsp. holarctica FTNF002-00 5522785 YP_001429313.2 CDS FTA_1881 NC_009749.1 1704539 1705015 R hypothetical protein complement(1704539..1705015) Francisella tularensis subsp. holarctica FTNF002-00 5524349 YP_001429316.1 CDS secG NC_009749.1 1706221 1706574 R preprotein translocase subunit SecG complement(1706221..1706574) Francisella tularensis subsp. holarctica FTNF002-00 5524401 YP_001429317.2 CDS tpiA NC_009749.1 1706562 1707323 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1706562..1707323) Francisella tularensis subsp. holarctica FTNF002-00 5524352 YP_001429318.1 CDS glmM NC_009749.1 1707326 1708657 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1707326..1708657) Francisella tularensis subsp. holarctica FTNF002-00 5524353 YP_001429319.1 CDS apt NC_009749.1 1708668 1709195 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1708668..1709195) Francisella tularensis subsp. holarctica FTNF002-00 5524354 YP_001429320.2 CDS sucB NC_009749.1 1709235 1710704 R 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase complement(1709235..1710704) Francisella tularensis subsp. holarctica FTNF002-00 5524355 YP_001429321.1 CDS sucA NC_009749.1 1710730 1713555 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(1710730..1713555) Francisella tularensis subsp. holarctica FTNF002-00 5524356 YP_001429322.1 CDS sdhB NC_009749.1 1713573 1714274 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit complement(1713573..1714274) Francisella tularensis subsp. holarctica FTNF002-00 5524357 YP_001429323.1 CDS sdhA NC_009749.1 1714292 1716085 R succinate dehydrogenase, flavoprotein subunit complement(1714292..1716085) Francisella tularensis subsp. holarctica FTNF002-00 5524358 YP_001429324.2 CDS FTA_1893 NC_009749.1 1716098 1716466 R hypothetical protein complement(1716098..1716466) Francisella tularensis subsp. holarctica FTNF002-00 5524359 YP_001429325.2 CDS FTA_1894 NC_009749.1 1716442 1716915 R succinate dehydrogenase, cytochrome b subunit complement(1716442..1716915) Francisella tularensis subsp. holarctica FTNF002-00 5524360 YP_001429326.2 CDS gltA NC_009749.1 1717158 1718432 D citrate synthase I 1717158..1718432 Francisella tularensis subsp. holarctica FTNF002-00 5524361 YP_001429327.1 CDS FTA_1896 NC_009749.1 1718521 1719786 D major facilitator transporter 1718521..1719786 Francisella tularensis subsp. holarctica FTNF002-00 5524362 YP_001429328.1 CDS FTA_1897 NC_009749.1 1719791 1719925 R hypothetical protein complement(1719791..1719925) Francisella tularensis subsp. holarctica FTNF002-00 5524363 YP_001429329.1 CDS FTA_1898 NC_009749.1 1719991 1720569 R Fe/Mn family superoxide dismutase complement(1719991..1720569) Francisella tularensis subsp. holarctica FTNF002-00 5522786 YP_001429330.1 CDS FTA_1899 NC_009749.1 1720705 1721034 D glutaredoxin-like protein 1720705..1721034 Francisella tularensis subsp. holarctica FTNF002-00 5522787 YP_001429331.2 CDS FTA_1900 NC_009749.1 1721051 1723894 R hypothetical protein complement(1721051..1723894) Francisella tularensis subsp. holarctica FTNF002-00 5522788 YP_001429332.1 CDS atpC NC_009749.1 1724105 1724542 R produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon complement(1724105..1724542) Francisella tularensis subsp. holarctica FTNF002-00 5522789 YP_001429333.1 CDS atpD NC_009749.1 1724555 1725931 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1724555..1725931) Francisella tularensis subsp. holarctica FTNF002-00 5522790 YP_001429334.2 CDS atpG NC_009749.1 1725941 1726837 R produces ATP from ADP in the presence of a proton gradient across the membrane; the gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1725941..1726837) Francisella tularensis subsp. holarctica FTNF002-00 5522791 YP_001429335.1 CDS atpA NC_009749.1 1726852 1728393 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1726852..1728393) Francisella tularensis subsp. holarctica FTNF002-00 5522792 YP_001429336.1 CDS atpH NC_009749.1 1728412 1728936 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1728412..1728936) Francisella tularensis subsp. holarctica FTNF002-00 5522793 YP_001429337.1 CDS atpF NC_009749.1 1728956 1729426 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1728956..1729426) Francisella tularensis subsp. holarctica FTNF002-00 5522794 YP_001429338.1 CDS atpE NC_009749.1 1729472 1729777 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1729472..1729777) Francisella tularensis subsp. holarctica FTNF002-00 5522795 YP_001429339.1 CDS atpB NC_009749.1 1729828 1730619 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1729828..1730619) Francisella tularensis subsp. holarctica FTNF002-00 5522796 YP_001429340.2 CDS FTA_1909 NC_009749.1 1730672 1731103 R hypothetical protein complement(1730672..1731103) Francisella tularensis subsp. holarctica FTNF002-00 5522797 YP_001429341.2 CDS FTA_1910 NC_009749.1 1731180 1732484 D major facilitator transporter 1731180..1732484 Francisella tularensis subsp. holarctica FTNF002-00 5522798 YP_001429342.1 CDS FTA_1911 NC_009749.1 1732486 1733415 R ribosomal large subunit pseudouridine synthase C complement(1732486..1733415) Francisella tularensis subsp. holarctica FTNF002-00 5522799 YP_001429343.1 CDS FTA_1912 NC_009749.1 1733408 1734475 R AFG1 family ATPase complement(1733408..1734475) Francisella tularensis subsp. holarctica FTNF002-00 5522800 YP_001429344.1 CDS FTA_1913 NC_009749.1 1734478 1735776 R major facilitator transporter complement(1734478..1735776) Francisella tularensis subsp. holarctica FTNF002-00 5522801 YP_001429345.1 CDS hisS NC_009749.1 1735783 1737048 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1735783..1737048) Francisella tularensis subsp. holarctica FTNF002-00 5523874 YP_001429346.1 CDS rbfA NC_009749.1 1737056 1737487 R ribosome-binding factor A complement(1737056..1737487) Francisella tularensis subsp. holarctica FTNF002-00 5523875 YP_001429347.1 CDS infB NC_009749.1 1737490 1740030 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1737490..1740030) Francisella tularensis subsp. holarctica FTNF002-00 5523876 YP_001429348.1 CDS nusA NC_009749.1 1740069 1741538 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1740069..1741538) Francisella tularensis subsp. holarctica FTNF002-00 5523877 YP_001429349.2 CDS FTA_1918 NC_009749.1 1741556 1742014 R hypothetical protein complement(1741556..1742014) Francisella tularensis subsp. holarctica FTNF002-00 5523878 YP_001429350.1 CDS hemE NC_009749.1 1742234 1743268 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(1742234..1743268) Francisella tularensis subsp. holarctica FTNF002-00 5524220 YP_001429353.2 CDS FTA_1922 NC_009749.1 1744760 1745640 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1744760..1745311,1745311..1745640)) Francisella tularensis subsp. holarctica FTNF002-00 5523882 YP_001429355.1 CDS FTA_1924 NC_009749.1 1745781 1745975 R hypothetical protein complement(1745781..1745975) Francisella tularensis subsp. holarctica FTNF002-00 5523884 YP_001429356.2 CDS FTA_1925 NC_009749.1 1746051 1747508 R NADH-quinone oxidoreductase subunit N complement(1746051..1747508) Francisella tularensis subsp. holarctica FTNF002-00 5523885 YP_001429357.1 CDS nuoM NC_009749.1 1747518 1749107 R NADH dehydrogenase I subunit M complement(1747518..1749107) Francisella tularensis subsp. holarctica FTNF002-00 5523886 YP_001429358.1 CDS nuoL NC_009749.1 1749133 1751142 R NADH dehydrogenase I subunit L complement(1749133..1751142) Francisella tularensis subsp. holarctica FTNF002-00 5523887 YP_001429359.2 CDS FTA_1928 NC_009749.1 1751152 1751484 R Sequence similarity to NADH dehydrogenase I subunit K (nuoK); NADH-ubiquinone oxidoreductase, chain 4L complement(1751152..1751484) Francisella tularensis subsp. holarctica FTNF002-00 5523888 YP_001429360.1 CDS FTA_1929 NC_009749.1 1751462 1752067 R sequence similarity to NADH dehydrogenase I subunit J (nuoJ); NADH dehydrogenase I subunit J complement(1751462..1752067) Francisella tularensis subsp. holarctica FTNF002-00 5523889 YP_001429361.1 CDS FTA_1930 NC_009749.1 1752072 1752560 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(1752072..1752560) Francisella tularensis subsp. holarctica FTNF002-00 5524306 YP_001429362.1 CDS FTA_1931 NC_009749.1 1752574 1753584 R Shows high %identity to NADH dehydrogenase I subunit H (nuoH), hence named based on sequence similarity using Blast; NADH dehydrogenase I subunit H complement(1752574..1753584) Francisella tularensis subsp. holarctica FTNF002-00 5524307 YP_001429363.1 CDS nuoG NC_009749.1 1753586 1755952 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit G complement(1753586..1755952) Francisella tularensis subsp. holarctica FTNF002-00 5524308 YP_001429364.2 CDS nuoF NC_009749.1 1755970 1757244 R NADH dehydrogenase I subunit F complement(1755970..1757244) Francisella tularensis subsp. holarctica FTNF002-00 5524309 YP_001429365.1 CDS nuoE NC_009749.1 1757251 1757739 R NADH dehydrogenase I subunit E complement(1757251..1757739) Francisella tularensis subsp. holarctica FTNF002-00 5524310 YP_001429366.1 CDS nuoD NC_009749.1 1757749 1759002 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D complement(1757749..1759002) Francisella tularensis subsp. holarctica FTNF002-00 5524311 YP_001429367.2 CDS nuoC NC_009749.1 1759024 1759674 R NADH dehydrogenase I subunit C complement(1759024..1759674) Francisella tularensis subsp. holarctica FTNF002-00 5524312 YP_001429368.1 CDS nuoB NC_009749.1 1759671 1760147 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(1759671..1760147) Francisella tularensis subsp. holarctica FTNF002-00 5524313 YP_001429369.1 CDS nuoA NC_009749.1 1760138 1760536 R Named NADH dehydrogenase I subunit A (nuoA) because of high sequence similarity by Blast; NADH dehydrogenase I subunit A complement(1760138..1760536) Francisella tularensis subsp. holarctica FTNF002-00 5524314 YP_001429370.1 CDS FTA_1939 NC_009749.1 1760745 1761167 D ferric uptake regulation protein 1760745..1761167 Francisella tularensis subsp. holarctica FTNF002-00 5524315 YP_001429371.1 CDS FTA_1940 NC_009749.1 1761421 1763340 D IucA/IucC family siderophore biosynthesis protein 1761421..1763340 Francisella tularensis subsp. holarctica FTNF002-00 5524316 YP_001429372.2 CDS FTA_1941 NC_009749.1 1763347 1764609 D major facilitator transporter 1763347..1764609 Francisella tularensis subsp. holarctica FTNF002-00 5524317 YP_001429373.1 CDS FTA_1942 NC_009749.1 1764602 1765855 D diaminopimelate decarboxylase 1764602..1765855 Francisella tularensis subsp. holarctica FTNF002-00 5524318 YP_001429374.1 CDS FTA_1943 NC_009749.1 1765871 1767061 D major facilitator transporter 1765871..1767061 Francisella tularensis subsp. holarctica FTNF002-00 5524319 YP_001429375.1 CDS FTA_1944 NC_009749.1 1767147 1768676 D hypothetical protein 1767147..1768676 Francisella tularensis subsp. holarctica FTNF002-00 5524320 YP_001429378.2 CDS FTA_1947 NC_009749.1 1770232 1770639 R hypothetical protein complement(1770232..1770639) Francisella tularensis subsp. holarctica FTNF002-00 5523360 YP_001429379.2 CDS gatB NC_009749.1 1770654 1772075 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(1770654..1772075) Francisella tularensis subsp. holarctica FTNF002-00 5523361 YP_001429380.1 CDS gatA NC_009749.1 1772078 1773523 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(1772078..1773523) Francisella tularensis subsp. holarctica FTNF002-00 5523362 YP_001429381.1 CDS gatC NC_009749.1 1773532 1773813 R Glu-tRNAGln amidotransferase subunit C complement(1773532..1773813) Francisella tularensis subsp. holarctica FTNF002-00 5523363 YP_001429386.1 CDS FTA_1955 NC_009749.1 1776600 1777178 R hypothetical protein complement(1776600..1777178) Francisella tularensis subsp. holarctica FTNF002-00 5523368 YP_001429387.1 CDS purB NC_009749.1 1777212 1778510 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1777212..1778510) Francisella tularensis subsp. holarctica FTNF002-00 5523369 YP_001429388.1 CDS FTA_1957 NC_009749.1 1778683 1779339 R transposase ISFTu2 complement(1778683..1779339) Francisella tularensis subsp. holarctica FTNF002-00 5523370 YP_001429391.2 CDS FTA_1960 NC_009749.1 1781136 1781996 R aldose 1-epimerase family protein complement(1781136..1781996) Francisella tularensis subsp. holarctica FTNF002-00 5523373 YP_001429392.1 CDS FTA_1961 NC_009749.1 1782281 1782895 R hypothetical protein complement(1782281..1782895) Francisella tularensis subsp. holarctica FTNF002-00 5523374 YP_001429397.1 CDS purL NC_009749.1 1784113 1787985 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(1784113..1787985) Francisella tularensis subsp. holarctica FTNF002-00 5524177 YP_001429398.1 CDS purF NC_009749.1 1787985 1789475 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(1787985..1789475) Francisella tularensis subsp. holarctica FTNF002-00 5524178 YP_001429402.2 CDS FTA_1971 NC_009749.1 1790883 1791527 R 4'-phosphopantetheinyl transferase complement(1790883..1791527) Francisella tularensis subsp. holarctica FTNF002-00 5524182 YP_001429403.1 CDS FTA_1972 NC_009749.1 1791533 1793062 R TolC family outer membrane efflux protein complement(1791533..1793062) Francisella tularensis subsp. holarctica FTNF002-00 5524183 YP_001429404.1 CDS FTA_1973 NC_009749.1 1793071 1793691 R protein-L-isoaspartate(D-aspartate) O-methyltransferase complement(1793071..1793691) Francisella tularensis subsp. holarctica FTNF002-00 5524184 YP_001429405.1 CDS FTA_1974 NC_009749.1 1794011 1795342 D peptidase U32 family protein 1794011..1795342 Francisella tularensis subsp. holarctica FTNF002-00 5524185 YP_001429406.2 CDS FTA_1975 NC_009749.1 1795382 1796572 R major facilitator superfamily multidrug resistance protein complement(1795382..1796572) Francisella tularensis subsp. holarctica FTNF002-00 5524186 YP_001429407.1 CDS FTA_1976 NC_009749.1 1796738 1798165 D Na+/H+ antiporter 1796738..1798165 Francisella tularensis subsp. holarctica FTNF002-00 5524187 YP_001429411.1 CDS FTA_1980 NC_009749.1 1799805 1801679 R amino acid transporter complement(1799805..1801679) Francisella tularensis subsp. holarctica FTNF002-00 5523804 YP_001429412.1 CDS obgE NC_009749.1 1801686 1802690 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1801686..1802690) Francisella tularensis subsp. holarctica FTNF002-00 5523805 YP_001429413.1 CDS FTA_1982 NC_009749.1 1802766 1803962 R tryptophan/tyrosine permease family protein complement(1802766..1803962) Francisella tularensis subsp. holarctica FTNF002-00 5523806 YP_001429416.1 CDS FTA_1985 NC_009749.1 1805259 1805630 R N-terminal truncated; transcriptional regulator complement(1805259..1805630) Francisella tularensis subsp. holarctica FTNF002-00 5523809 YP_001429420.1 CDS kdpC NC_009749.1 1808760 1809314 R potassium-transporting ATPase C chain complement(1808760..1809314) Francisella tularensis subsp. holarctica FTNF002-00 5523813 YP_001429423.1 CDS kdpA NC_009749.1 1811318 1813039 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(1811318..1813039) Francisella tularensis subsp. holarctica FTNF002-00 5523816 YP_001429425.1 CDS FTA_1994 NC_009749.1 1813515 1814330 R transposase ISFTu2 complement(1813515..1814330) Francisella tularensis subsp. holarctica FTNF002-00 5522802 YP_001429426.2 CDS FTA_1995 NC_009749.1 1814521 1815350 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1814521..1815021,1815021..1815350)) Francisella tularensis subsp. holarctica FTNF002-00 5522803 YP_001429429.1 CDS leuD NC_009749.1 1816588 1817157 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(1816588..1817157) Francisella tularensis subsp. holarctica FTNF002-00 5522806 YP_001429430.1 CDS leuC NC_009749.1 1817160 1818563 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(1817160..1818563) Francisella tularensis subsp. holarctica FTNF002-00 5522807 YP_001429431.2 CDS FTA_2000 NC_009749.1 1818857 1819686 D programmed ribosomal frameshift; transposase ISFtu1 join(1818857..1819186,1819186..1819686) Francisella tularensis subsp. holarctica FTNF002-00 5522808 YP_001429433.1 CDS FTA_2002 NC_009749.1 1819877 1820557 D transposase ISFTu2 1819877..1820557 Francisella tularensis subsp. holarctica FTNF002-00 5522810 YP_001429435.1 CDS FTA_2004 NC_009749.1 1822621 1823139 R lipocalin-like domain-containing lipoprotein complement(1822621..1823139) Francisella tularensis subsp. holarctica FTNF002-00 5522812 YP_001429436.1 CDS holA NC_009749.1 1823225 1824202 D DNA polymerase III subunit delta 1823225..1824202 Francisella tularensis subsp. holarctica FTNF002-00 5522813 YP_001429437.1 CDS glnA NC_009749.1 1824322 1825359 D glutamine synthetase 1824322..1825359 Francisella tularensis subsp. holarctica FTNF002-00 5522814 YP_001429438.2 CDS FTA_2007 NC_009749.1 1825441 1826982 D glutaminase 1825441..1826982 Francisella tularensis subsp. holarctica FTNF002-00 5522815 YP_001429440.1 CDS FTA_2009 NC_009749.1 1827976 1828518 D hypothetical protein 1827976..1828518 Francisella tularensis subsp. holarctica FTNF002-00 5522817 YP_001429441.1 CDS lysS NC_009749.1 1828903 1830633 R lysyl-tRNA synthetase complement(1828903..1830633) Francisella tularensis subsp. holarctica FTNF002-00 5524478 YP_001429442.1 CDS prfB NC_009749.1 1830763 1831740 R peptide chain release factor 2 complement(1830763..1831740) Francisella tularensis subsp. holarctica FTNF002-00 5524479 YP_001429443.1 CDS dnaX NC_009749.1 1832013 1833650 D DNA polymerase III subunits gamma/tau 1832013..1833650 Francisella tularensis subsp. holarctica FTNF002-00 5524480 YP_001429444.1 CDS lpxC NC_009749.1 1833664 1834524 R zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase complement(1833664..1834524) Francisella tularensis subsp. holarctica FTNF002-00 5524481 YP_001429445.1 CDS ftsZ NC_009749.1 1834547 1835692 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1834547..1835692) Francisella tularensis subsp. holarctica FTNF002-00 5524482 YP_001429446.1 CDS ftsA NC_009749.1 1835736 1836998 R cell division protein FtsA complement(1835736..1836998) Francisella tularensis subsp. holarctica FTNF002-00 5524483 YP_001429447.1 CDS FTA_2016 NC_009749.1 1837100 1837783 R cell division protein FtsQ complement(1837100..1837783) Francisella tularensis subsp. holarctica FTNF002-00 5524484 YP_001429448.1 CDS FTA_2017 NC_009749.1 1837780 1838670 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1837780..1838670) Francisella tularensis subsp. holarctica FTNF002-00 5524485 YP_001429449.1 CDS FTA_2018 NC_009749.1 1838674 1839135 R cytidine/deoxycytidylate deaminase zinc-binding domain-containing protein complement(1838674..1839135) Francisella tularensis subsp. holarctica FTNF002-00 5524486 YP_001429450.2 CDS rpsA NC_009749.1 1839229 1840953 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1839229..1840953 Francisella tularensis subsp. holarctica FTNF002-00 5524487 YP_001429451.1 CDS FTA_2020 NC_009749.1 1841070 1841612 D YrdC domain-containing protein 1841070..1841612 Francisella tularensis subsp. holarctica FTNF002-00 5524488 YP_001429452.1 CDS FTA_2021 NC_009749.1 1841710 1842246 D hypothetical protein 1841710..1842246 Francisella tularensis subsp. holarctica FTNF002-00 5524489 YP_001429453.2 CDS FTA_2022 NC_009749.1 1842632 1843522 R putative acyltransferase complement(1842632..1843522) Francisella tularensis subsp. holarctica FTNF002-00 5524490 YP_001429454.1 CDS FTA_2023 NC_009749.1 1843332 1843496 D hypothetical protein 1843332..1843496 Francisella tularensis subsp. holarctica FTNF002-00 5524491 YP_001429455.1 CDS FTA_2024 NC_009749.1 1843623 1845638 R ComEC/Rec2-related competence protein complement(1843623..1845638) Francisella tularensis subsp. holarctica FTNF002-00 5524492 YP_001429460.1 CDS FTA_2030 NC_009749.1 1849207 1849989 D ABC transporter ATP-binding protein 1849207..1849989 Francisella tularensis subsp. holarctica FTNF002-00 5523189 YP_001429461.1 CDS FTA_2029 NC_009749.1 1849983 1850552 R YGGT family membrane protein complement(1849983..1850552) Francisella tularensis subsp. holarctica FTNF002-00 5523191 YP_001429462.1 CDS FTA_2031 NC_009749.1 1850667 1851482 R hypothetical protein complement(1850667..1851482) Francisella tularensis subsp. holarctica FTNF002-00 5523190 YP_001429463.2 CDS FTA_2032 NC_009749.1 1851552 1851962 R hypothetical protein complement(1851552..1851962) Francisella tularensis subsp. holarctica FTNF002-00 5523192 YP_001429464.2 CDS FTA_2033 NC_009749.1 1851907 1852787 R programmed ribosomal frameshift; transposase ISFtu1 complement(join(1851907..1852458,1852458..1852787)) Francisella tularensis subsp. holarctica FTNF002-00 5523193 YP_001429466.1 CDS FTA_2035 NC_009749.1 1852849 1853334 R transposase ISFTu2 complement(1852849..1853334) Francisella tularensis subsp. holarctica FTNF002-00 5523195 YP_001429469.1 CDS purH NC_009749.1 1854705 1856252 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(1854705..1856252) Francisella tularensis subsp. holarctica FTNF002-00 5523198 YP_001429470.1 CDS purA NC_009749.1 1856429 1857715 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1856429..1857715 Francisella tularensis subsp. holarctica FTNF002-00 5523199 YP_001429471.1 CDS hpt NC_009749.1 1857719 1858252 D hypoxanthine-guanine phosphoribosyltransferase 1857719..1858252 Francisella tularensis subsp. holarctica FTNF002-00 5523200 YP_001429474.2 CDS FTA_2043 NC_009749.1 1859082 1859945 R ABC 3 transporter family protein complement(1859082..1859945) Francisella tularensis subsp. holarctica FTNF002-00 5523390 YP_001429475.2 CDS FTA_2044 NC_009749.1 1859866 1860594 R ABC transporter ATP-binding protein complement(1859866..1860594) Francisella tularensis subsp. holarctica FTNF002-00 5523391 YP_001429476.1 CDS FTA_2045 NC_009749.1 1860545 1861462 R periplasmic solute binding family protein complement(1860545..1861462) Francisella tularensis subsp. holarctica FTNF002-00 5523392 YP_001429480.1 CDS FTA_2049 NC_009749.1 1862872 1863336 R outer membrane lipoprotein complement(1862872..1863336) Francisella tularensis subsp. holarctica FTNF002-00 5523396 YP_001429481.1 CDS FTA_2050 NC_009749.1 1863347 1863943 R flavodoxin domain-containing protein complement(1863347..1863943) Francisella tularensis subsp. holarctica FTNF002-00 5523397 YP_001429482.1 CDS FTA_2051 NC_009749.1 1863950 1865137 D YihY family membrane protein 1863950..1865137 Francisella tularensis subsp. holarctica FTNF002-00 5523398 YP_001429483.1 CDS FTA_2052 NC_009749.1 1865156 1865731 D nicotinamide mononucleotide transporter, PnuC family protein 1865156..1865731 Francisella tularensis subsp. holarctica FTNF002-00 5523399 YP_001429484.1 CDS priA NC_009749.1 1865728 1867881 D primosomal protein N' 1865728..1867881 Francisella tularensis subsp. holarctica FTNF002-00 5523400 YP_001429485.2 CDS FTA_2054 NC_009749.1 1868027 1868907 D programmed ribosomal frameshift; transposase ISFtu1 join(1868027..1868356,1868356..1868907) Francisella tularensis subsp. holarctica FTNF002-00 5523401 YP_001429488.1 CDS FTA_2057 NC_009749.1 1869742 1871421 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein complement(1869742..1871421) Francisella tularensis subsp. holarctica FTNF002-00 5523404 YP_001429489.2 CDS FTA_2058 NC_009749.1 1871589 1872866 D major facilitator transporter 1871589..1872866 Francisella tularensis subsp. holarctica FTNF002-00 5524636 YP_001429491.1 CDS FTA_2060 NC_009749.1 1873173 1873385 R hypothetical protein complement(1873173..1873385) Francisella tularensis subsp. holarctica FTNF002-00 5524638 YP_001429492.1 CDS FTA_2061 NC_009749.1 1873431 1874411 D hypothetical protein 1873431..1874411 Francisella tularensis subsp. holarctica FTNF002-00 5524639 YP_001429497.1 CDS FTA_2066 NC_009749.1 1876307 1876450 D hypothetical protein 1876307..1876450 Francisella tularensis subsp. holarctica FTNF002-00 5524644 YP_001429500.1 CDS FTA_2069 NC_009749.1 1877350 1877829 R IS1016 family transposase complement(1877350..1877829) Francisella tularensis subsp. holarctica FTNF002-00 5524647 YP_001429501.2 CDS pepN NC_009749.1 1877902 1880496 R aminopeptidase N complement(1877902..1880496) Francisella tularensis subsp. holarctica FTNF002-00 5524648 YP_001429502.1 CDS FTA_2072 NC_009749.1 1880680 1881108 D HSP20 family protein 1880680..1881108 Francisella tularensis subsp. holarctica FTNF002-00 5524649 YP_001429503.1 CDS trpCF NC_009749.1 1881105 1882466 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1881105..1882466) Francisella tularensis subsp. holarctica FTNF002-00 5524651 YP_001429504.1 CDS FTA_2073 NC_009749.1 1882558 1882737 R N-terminal truncation; hypothetical protein complement(1882558..1882737) Francisella tularensis subsp. holarctica FTNF002-00 5524650 YP_001429505.1 CDS msrA NC_009749.1 1882976 1883665 R methionine-S-sulfoxide reductase complement(1882976..1883665) Francisella tularensis subsp. holarctica FTNF002-00 5524322 YP_001429506.1 CDS FTA_2075 NC_009749.1 1883749 1884117 R hypothetical protein complement(1883749..1884117) Francisella tularensis subsp. holarctica FTNF002-00 5524323 YP_001429507.1 CDS FTA_2076 NC_009749.1 1884110 1884451 R hypothetical protein complement(1884110..1884451) Francisella tularensis subsp. holarctica FTNF002-00 5524324 YP_001429508.2 CDS FTA_2077 NC_009749.1 1884520 1884960 R hypothetical protein complement(1884520..1884960) Francisella tularensis subsp. holarctica FTNF002-00 5524325 YP_001429509.1 CDS trpD NC_009749.1 1885022 1886047 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1885022..1886047) Francisella tularensis subsp. holarctica FTNF002-00 5524326 YP_001429510.1 CDS FTA_2079 NC_009749.1 1886032 1886610 R glutamine amidotransferase of anthranilate synthase/para-aminobenzoate synthase complement(1886032..1886610) Francisella tularensis subsp. holarctica FTNF002-00 5524327 YP_001429511.1 CDS trpE NC_009749.1 1886614 1888158 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1886614..1888158) Francisella tularensis subsp. holarctica FTNF002-00 5524328 YP_001429512.1 CDS trpR NC_009749.1 1888167 1888454 R trp operon repressor complement(1888167..1888454) Francisella tularensis subsp. holarctica FTNF002-00 5524329 YP_001429513.2 CDS FTA_2082 NC_009749.1 1888928 1890424 R ribonuclease, Rne/Rng family protein complement(1888928..1890424) Francisella tularensis subsp. holarctica FTNF002-00 5524259 FTA_2118 tRNA FTA_2118 NC_009749.1 126030 126106 D tRNA-Ile 126030..126106 Francisella tularensis subsp. holarctica FTNF002-00 5523822 FTA_2096 tRNA FTA_2096 NC_009749.1 126121 126196 D tRNA-Ala 126121..126196 Francisella tularensis subsp. holarctica FTNF002-00 5524154 FTA_2089 tRNA FTA_2089 NC_009749.1 158224 158298 D tRNA-Gln 158224..158298 Francisella tularensis subsp. holarctica FTNF002-00 5523482 FTA_2088 tRNA FTA_2088 NC_009749.1 222959 223034 D tRNA-Glu 222959..223034 Francisella tularensis subsp. holarctica FTNF002-00 5523146 FTA_2104 tRNA FTA_2104 NC_009749.1 292834 292908 R tRNA-Gly complement(292834..292908) Francisella tularensis subsp. holarctica FTNF002-00 5523787 FTA_2099 tRNA FTA_2099 NC_009749.1 292923 292999 R tRNA-Arg complement(292923..292999) Francisella tularensis subsp. holarctica FTNF002-00 5524335 FTA_2092 tRNA FTA_2092 NC_009749.1 327480 327569 D tRNA-Ser 327480..327569 Francisella tularensis subsp. holarctica FTNF002-00 5524525 FTA_2093 tRNA FTA_2093 NC_009749.1 415982 416073 D tRNA-Ser 415982..416073 Francisella tularensis subsp. holarctica FTNF002-00 5523635 FTA_2112 tRNA FTA_2112 NC_009749.1 416101 416176 D tRNA-Val 416101..416176 Francisella tularensis subsp. holarctica FTNF002-00 5523637 FTA_2119 tRNA FTA_2119 NC_009749.1 419017 419093 D tRNA-Ile 419017..419093 Francisella tularensis subsp. holarctica FTNF002-00 5523638 FTA_2097 tRNA FTA_2097 NC_009749.1 419108 419183 D tRNA-Ala 419108..419183 Francisella tularensis subsp. holarctica FTNF002-00 5524155 FTA_2108 tRNA FTA_2108 NC_009749.1 528800 528876 R tRNA-Met complement(528800..528876) Francisella tularensis subsp. holarctica FTNF002-00 5523890 FTA_2084 tRNA FTA_2084 NC_009749.1 608888 608974 D tRNA-Leu 608888..608974 Francisella tularensis subsp. holarctica FTNF002-00 5522631 FTA_2091 tRNA FTA_2091 NC_009749.1 638397 638472 R tRNA-Asn complement(638397..638472) Francisella tularensis subsp. holarctica FTNF002-00 5523646 FTA_2105 tRNA FTA_2105 NC_009749.1 645724 645798 D tRNA-Gly 645724..645798 Francisella tularensis subsp. holarctica FTNF002-00 5523654 FTA_2102 tRNA FTA_2102 NC_009749.1 645814 645887 D tRNA-Cys 645814..645887 Francisella tularensis subsp. holarctica FTNF002-00 5524224 FTA_2085 tRNA FTA_2085 NC_009749.1 645893 645981 D tRNA-Leu 645893..645981 Francisella tularensis subsp. holarctica FTNF002-00 5522979 FTA_2120 tRNA FTA_2120 NC_009749.1 1121336 1121412 D tRNA-Ile 1121336..1121412 Francisella tularensis subsp. holarctica FTNF002-00 5524153 FTA_2098 tRNA FTA_2098 NC_009749.1 1121427 1121502 D tRNA-Ala 1121427..1121502 Francisella tularensis subsp. holarctica FTNF002-00 5524255 FTA_2113 tRNA FTA_2113 NC_009749.1 1229484 1229560 D tRNA-Val 1229484..1229560 Francisella tularensis subsp. holarctica FTNF002-00 5523624 FTA_2094 tRNA FTA_2094 NC_009749.1 1292757 1292844 D tRNA-Ser 1292757..1292844 Francisella tularensis subsp. holarctica FTNF002-00 5524285 FTA_2086 tRNA FTA_2086 NC_009749.1 1347166 1347248 R tRNA-Leu complement(1347166..1347248) Francisella tularensis subsp. holarctica FTNF002-00 5524435 FTA_2090 tRNA FTA_2090 NC_009749.1 1347255 1347330 R tRNA-His complement(1347255..1347330) Francisella tularensis subsp. holarctica FTNF002-00 5524400 FTA_2100 tRNA FTA_2100 NC_009749.1 1347358 1347434 R tRNA-Arg complement(1347358..1347434) Francisella tularensis subsp. holarctica FTNF002-00 5524659 FTA_2117 tRNA FTA_2117 NC_009749.1 1347443 1347519 R tRNA-Pro complement(1347443..1347519) Francisella tularensis subsp. holarctica FTNF002-00 5522981 FTA_2107 tRNA FTA_2107 NC_009749.1 1347537 1347612 R tRNA-Phe complement(1347537..1347612) Francisella tularensis subsp. holarctica FTNF002-00 5524258 FTA_2083 tRNA FTA_2083 NC_009749.1 1410085 1410160 R tRNA-Lys complement(1410085..1410160) Francisella tularensis subsp. holarctica FTNF002-00 5523166 FTA_2114 tRNA FTA_2114 NC_009749.1 1458931 1459006 R tRNA-Val complement(1458931..1459006) Francisella tularensis subsp. holarctica FTNF002-00 5522838 FTA_2109 tRNA FTA_2109 NC_009749.1 1638666 1638742 D tRNA-Met 1638666..1638742 Francisella tularensis subsp. holarctica FTNF002-00 5524094 FTA_2101 tRNA FTA_2101 NC_009749.1 1643816 1643891 D tRNA-Arg 1643816..1643891 Francisella tularensis subsp. holarctica FTNF002-00 5524101 FTA_2095 tRNA FTA_2095 NC_009749.1 1680772 1680847 R tRNA-Trp complement(1680772..1680847) Francisella tularensis subsp. holarctica FTNF002-00 5524454 FTA_2115 tRNA FTA_2115 NC_009749.1 1682096 1682171 R tRNA-Thr complement(1682096..1682171) Francisella tularensis subsp. holarctica FTNF002-00 5524455 FTA_2106 tRNA FTA_2106 NC_009749.1 1682200 1682273 R tRNA-Gly complement(1682200..1682273) Francisella tularensis subsp. holarctica FTNF002-00 5524260 FTA_2111 tRNA FTA_2111 NC_009749.1 1682275 1682359 R tRNA-Tyr complement(1682275..1682359) Francisella tularensis subsp. holarctica FTNF002-00 5522976 FTA_2087 tRNA FTA_2087 NC_009749.1 1706127 1706212 R tRNA-Leu complement(1706127..1706212) Francisella tularensis subsp. holarctica FTNF002-00 5524351 FTA_2110 tRNA FTA_2110 NC_009749.1 1742084 1742160 R tRNA-Met complement(1742084..1742160) Francisella tularensis subsp. holarctica FTNF002-00 5523879 FTA_2103 tRNA FTA_2103 NC_009749.1 1888710 1888786 R tRNA-Asp complement(1888710..1888786) Francisella tularensis subsp. holarctica FTNF002-00 5524330 FTA_2116 tRNA FTA_2116 NC_009749.1 1888791 1888866 R tRNA-Thr complement(1888791..1888866) Francisella tularensis subsp. holarctica FTNF002-00 5522978 FTA_2130 rRNA FTA_2130 NC_009749.1 124406 125934 D 16S ribosomal RNA 124406..125934 Francisella tularensis subsp. holarctica FTNF002-00 5523821 FTA_2122 rRNA FTA_2122 NC_009749.1 126186 129137 D 23S ribosomal RNA 126186..129137 Francisella tularensis subsp. holarctica FTNF002-00 5524257 FTA_2134 rRNA FTA_2134 NC_009749.1 129182 129296 D 5S ribosomal RNA 129182..129296 Francisella tularensis subsp. holarctica FTNF002-00 5524653 FTA_2131 rRNA FTA_2131 NC_009749.1 417393 418921 D 16S ribosomal RNA 417393..418921 Francisella tularensis subsp. holarctica FTNF002-00 5524218 FTA_2123 rRNA FTA_2123 NC_009749.1 419173 422124 D 23S ribosomal RNA 419173..422124 Francisella tularensis subsp. holarctica FTNF002-00 5524256 FTA_2135 rRNA FTA_2135 NC_009749.1 422169 422283 D 5S ribosomal RNA 422169..422283 Francisella tularensis subsp. holarctica FTNF002-00 5524652 FTA_2137 rRNA FTA_2137 NC_009749.1 451867 451981 D 5S ribosomal RNA 451867..451981 Francisella tularensis subsp. holarctica FTNF002-00 5523209 FTA_2132 rRNA FTA_2132 NC_009749.1 1119712 1121240 D 16S ribosomal RNA 1119712..1121240 Francisella tularensis subsp. holarctica FTNF002-00 5522933 FTA_2125 rRNA FTA_2125 NC_009749.1 1121492 1124443 D 23S ribosomal RNA 1121492..1124443 Francisella tularensis subsp. holarctica FTNF002-00 5522983 FTA_2136 rRNA FTA_2136 NC_009749.1 1124488 1124602 D 5S ribosomal RNA 1124488..1124602 Francisella tularensis subsp. holarctica FTNF002-00 5524254