-- dump date 20140619_095145 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1232394000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1232394000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1232394000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394000004 Walker A motif; other site 1232394000005 ATP binding site [chemical binding]; other site 1232394000006 Walker B motif; other site 1232394000007 arginine finger; other site 1232394000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1232394000009 DnaA box-binding interface [nucleotide binding]; other site 1232394000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1232394000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1232394000012 putative DNA binding surface [nucleotide binding]; other site 1232394000013 dimer interface [polypeptide binding]; other site 1232394000014 beta-clamp/clamp loader binding surface; other site 1232394000015 beta-clamp/translesion DNA polymerase binding surface; other site 1232394000016 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394000017 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000020 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000021 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232394000022 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1232394000023 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1232394000024 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1232394000025 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1232394000026 TPP-binding site [chemical binding]; other site 1232394000027 dimer interface [polypeptide binding]; other site 1232394000028 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1232394000029 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1232394000030 tandem repeat interface [polypeptide binding]; other site 1232394000031 oligomer interface [polypeptide binding]; other site 1232394000032 active site residues [active] 1232394000033 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1232394000034 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232394000035 preprotein translocase subunit SecB; Provisional; Region: PRK13031 1232394000036 SecA binding site; other site 1232394000037 Preprotein binding site; other site 1232394000038 recombinase A; Provisional; Region: recA; PRK09354 1232394000039 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1232394000040 hexamer interface [polypeptide binding]; other site 1232394000041 Walker A motif; other site 1232394000042 ATP binding site [chemical binding]; other site 1232394000043 Walker B motif; other site 1232394000044 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1232394000045 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1232394000046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1232394000047 dimer interface [polypeptide binding]; other site 1232394000048 ssDNA binding site [nucleotide binding]; other site 1232394000049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232394000050 propionate/acetate kinase; Provisional; Region: PRK12379 1232394000051 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1232394000052 phosphate acetyltransferase; Reviewed; Region: PRK05632 1232394000053 DRTGG domain; Region: DRTGG; pfam07085 1232394000054 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1232394000055 potential frameshift: common BLAST hit: gi|118496742|ref|YP_897792.1| succinate semialdehyde dehydrogenase 1232394000056 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000059 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232394000061 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1232394000062 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1232394000063 dimer interface [polypeptide binding]; other site 1232394000064 anticodon binding site; other site 1232394000065 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1232394000066 homodimer interface [polypeptide binding]; other site 1232394000067 motif 1; other site 1232394000068 active site 1232394000069 motif 2; other site 1232394000070 GAD domain; Region: GAD; pfam02938 1232394000071 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232394000072 active site 1232394000073 motif 3; other site 1232394000074 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394000075 potential frameshift: common BLAST hit: gi|118496742|ref|YP_897792.1| succinate semialdehyde dehydrogenase 1232394000076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000077 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000078 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000080 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1232394000081 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1232394000082 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1232394000083 potential frameshift: common BLAST hit: gi|134302746|ref|YP_001122714.1| dehydrogenase 1232394000084 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1232394000085 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1232394000086 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1232394000087 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1232394000088 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232394000089 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1232394000090 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1232394000091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232394000092 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232394000093 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1232394000094 substrate binding site [chemical binding]; other site 1232394000095 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1232394000096 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1232394000097 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1232394000098 catalytic site [active] 1232394000099 subunit interface [polypeptide binding]; other site 1232394000100 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1232394000101 catalytic core [active] 1232394000102 thiopurine S-methyltransferase; Reviewed; Region: PRK13256 1232394000103 dihydroorotase; Reviewed; Region: PRK09236 1232394000104 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232394000105 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1232394000106 active site 1232394000107 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 1232394000108 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 1232394000109 HlyD family secretion protein; Region: HlyD; pfam00529 1232394000110 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1232394000111 HlyD family secretion protein; Region: HlyD_3; pfam13437 1232394000112 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1232394000113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394000114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232394000115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232394000116 dimerization interface [polypeptide binding]; other site 1232394000117 SOUL heme-binding protein; Region: SOUL; pfam04832 1232394000118 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000120 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394000121 Chorismate mutase type II; Region: CM_2; smart00830 1232394000122 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1232394000123 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1232394000124 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1232394000125 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1232394000126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1232394000127 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1232394000128 active site 1232394000129 dimer interface [polypeptide binding]; other site 1232394000130 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232394000131 phosphate binding site [ion binding]; other site 1232394000132 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1232394000133 prephenate dehydrogenase; Provisional; Region: PRK06444 1232394000134 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1232394000135 putative active site [active] 1232394000136 dimerization interface [polypeptide binding]; other site 1232394000137 putative tRNAtyr binding site [nucleotide binding]; other site 1232394000138 potential frameshift: common BLAST hit: gi|385795371|ref|YP_005831777.1| Major Facilitator Superfamily (MFS) transporter family protein 1232394000139 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 1232394000140 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1232394000141 substrate binding [chemical binding]; other site 1232394000142 active site 1232394000143 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000145 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000146 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000147 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1232394000148 putative FMN binding site [chemical binding]; other site 1232394000149 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232394000150 aromatic amino acid transport protein; Region: araaP; TIGR00837 1232394000151 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1232394000152 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1232394000153 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1232394000154 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232394000155 catalytic residue [active] 1232394000156 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232394000157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394000158 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1232394000159 putative effector binding pocket; other site 1232394000160 dimerization interface [polypeptide binding]; other site 1232394000161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394000162 putative substrate translocation pore; other site 1232394000163 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1232394000164 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1232394000165 dimer interface [polypeptide binding]; other site 1232394000166 active site 1232394000167 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1232394000168 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1232394000169 GTP-binding protein LepA; Provisional; Region: PRK05433 1232394000170 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1232394000171 G1 box; other site 1232394000172 putative GEF interaction site [polypeptide binding]; other site 1232394000173 GTP/Mg2+ binding site [chemical binding]; other site 1232394000174 Switch I region; other site 1232394000175 G2 box; other site 1232394000176 G3 box; other site 1232394000177 Switch II region; other site 1232394000178 G4 box; other site 1232394000179 G5 box; other site 1232394000180 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1232394000181 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1232394000182 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1232394000183 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1232394000184 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1232394000185 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1232394000186 active site 1232394000187 catalytic residues [active] 1232394000188 metal binding site [ion binding]; metal-binding site 1232394000189 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1232394000190 homopentamer interface [polypeptide binding]; other site 1232394000191 active site 1232394000192 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1232394000193 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1232394000194 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1232394000195 dimerization interface [polypeptide binding]; other site 1232394000196 active site 1232394000197 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1232394000198 Lumazine binding domain; Region: Lum_binding; pfam00677 1232394000199 Lumazine binding domain; Region: Lum_binding; pfam00677 1232394000200 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1232394000201 catalytic motif [active] 1232394000202 Zn binding site [ion binding]; other site 1232394000203 RibD C-terminal domain; Region: RibD_C; cl17279 1232394000204 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000206 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394000207 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000210 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394000212 putative substrate translocation pore; other site 1232394000213 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1232394000214 potential frameshift: common BLAST hit: gi|134301190|ref|YP_001121158.1| Rieske (2Fe-2S) domain-containing protein 1232394000215 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14854 1232394000216 hypothetical protein; Provisional; Region: PRK05421 1232394000217 putative catalytic site [active] 1232394000218 putative metal binding site [ion binding]; other site 1232394000219 putative phosphate binding site [ion binding]; other site 1232394000220 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232394000221 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232394000222 putative acyl-acceptor binding pocket; other site 1232394000223 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232394000224 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1232394000225 putative acyl-acceptor binding pocket; other site 1232394000226 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1232394000227 4Fe-4S binding domain; Region: Fer4; cl02805 1232394000228 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1232394000229 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232394000230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232394000231 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1232394000232 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232394000233 ATP-grasp domain; Region: ATP-grasp; pfam02222 1232394000234 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1232394000235 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1232394000236 active site 1232394000237 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1232394000238 Clp amino terminal domain; Region: Clp_N; pfam02861 1232394000239 Clp amino terminal domain; Region: Clp_N; pfam02861 1232394000240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394000241 Walker A motif; other site 1232394000242 ATP binding site [chemical binding]; other site 1232394000243 Walker B motif; other site 1232394000244 arginine finger; other site 1232394000245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394000246 Walker A motif; other site 1232394000247 ATP binding site [chemical binding]; other site 1232394000248 Walker B motif; other site 1232394000249 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1232394000250 potential frameshift: common BLAST hit: gi|118498298|ref|YP_899348.1| nicotinamide mononucleotide transporter 1232394000251 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1232394000252 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1232394000253 substrate binding site [chemical binding]; other site 1232394000254 active site 1232394000255 catalytic residues [active] 1232394000256 heterodimer interface [polypeptide binding]; other site 1232394000257 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1232394000258 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1232394000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394000260 catalytic residue [active] 1232394000261 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1232394000262 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1232394000263 active site 1232394000264 Zn binding site [ion binding]; other site 1232394000265 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1232394000266 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1232394000267 Cl- selectivity filter; other site 1232394000268 Cl- binding residues [ion binding]; other site 1232394000269 pore gating glutamate residue; other site 1232394000270 dimer interface [polypeptide binding]; other site 1232394000271 H+/Cl- coupling transport residue; other site 1232394000272 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1232394000273 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1232394000274 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1232394000275 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1232394000276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000277 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000278 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394000281 putative substrate translocation pore; other site 1232394000282 potential frameshift: common BLAST hit: gi|385795501|ref|YP_005831907.1| pathogenicity determinant protein D, pdpD 1232394000283 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 1232394000284 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1232394000285 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1232394000286 Intracellular growth locus C protein; Region: IglC; pfam11550 1232394000287 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1232394000288 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1232394000289 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1232394000290 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1232394000291 potential frameshift: common BLAST hit: gi|115314074|ref|YP_762797.1| formate dehydrogenase 1232394000292 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000293 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000294 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000296 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1232394000297 active site 1232394000298 metal binding site [ion binding]; metal-binding site 1232394000299 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1232394000300 catalytic residues [active] 1232394000301 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1232394000302 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1232394000303 homodimer interface [polypeptide binding]; other site 1232394000304 substrate-cofactor binding pocket; other site 1232394000305 catalytic residue [active] 1232394000306 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1232394000307 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1232394000308 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1232394000309 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1232394000310 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1232394000311 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1232394000312 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1232394000313 G1 box; other site 1232394000314 GTP/Mg2+ binding site [chemical binding]; other site 1232394000315 Switch I region; other site 1232394000316 G2 box; other site 1232394000317 G3 box; other site 1232394000318 Switch II region; other site 1232394000319 G4 box; other site 1232394000320 G5 box; other site 1232394000321 Nucleoside recognition; Region: Gate; pfam07670 1232394000322 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1232394000323 Nucleoside recognition; Region: Gate; pfam07670 1232394000324 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000327 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000328 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 1232394000329 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1232394000330 RNB domain; Region: RNB; pfam00773 1232394000331 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1232394000332 putative hydrolase; Provisional; Region: PRK11460 1232394000333 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1232394000334 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1232394000335 domain interfaces; other site 1232394000336 active site 1232394000337 camphor resistance protein CrcB; Provisional; Region: PRK14226 1232394000338 Zinc-finger domain; Region: zf-CHCC; cl01821 1232394000339 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1232394000340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232394000341 dimer interface [polypeptide binding]; other site 1232394000342 conserved gate region; other site 1232394000343 putative PBP binding loops; other site 1232394000344 ABC-ATPase subunit interface; other site 1232394000345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232394000346 dimer interface [polypeptide binding]; other site 1232394000347 conserved gate region; other site 1232394000348 putative PBP binding loops; other site 1232394000349 ABC-ATPase subunit interface; other site 1232394000350 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1232394000351 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1232394000352 Walker A/P-loop; other site 1232394000353 ATP binding site [chemical binding]; other site 1232394000354 Q-loop/lid; other site 1232394000355 ABC transporter signature motif; other site 1232394000356 Walker B; other site 1232394000357 D-loop; other site 1232394000358 H-loop/switch region; other site 1232394000359 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1232394000360 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1232394000361 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232394000362 TrkA-N domain; Region: TrkA_N; pfam02254 1232394000363 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1232394000364 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1232394000365 trimer interface [polypeptide binding]; other site 1232394000366 putative metal binding site [ion binding]; other site 1232394000367 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1232394000368 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1232394000369 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1232394000370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000371 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000372 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000374 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1232394000375 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1232394000376 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1232394000377 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1232394000378 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1232394000379 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1232394000380 LamB/YcsF family protein; Provisional; Region: PRK05406 1232394000381 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1232394000382 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1232394000383 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394000384 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394000385 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000388 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000389 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1232394000390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232394000391 Ligand Binding Site [chemical binding]; other site 1232394000392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1232394000393 Ligand Binding Site [chemical binding]; other site 1232394000394 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1232394000395 PLD-like domain; Region: PLDc_2; pfam13091 1232394000396 putative homodimer interface [polypeptide binding]; other site 1232394000397 putative active site [active] 1232394000398 catalytic site [active] 1232394000399 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1232394000400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394000401 ATP binding site [chemical binding]; other site 1232394000402 putative Mg++ binding site [ion binding]; other site 1232394000403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394000404 nucleotide binding region [chemical binding]; other site 1232394000405 ATP-binding site [chemical binding]; other site 1232394000406 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1232394000407 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1232394000408 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1232394000409 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1232394000410 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1232394000411 Mitochondrial PGP phosphatase; Region: PGP_phosphatase; pfam09419 1232394000412 Predicted methyltransferases [General function prediction only]; Region: COG0313 1232394000413 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1232394000414 putative SAM binding site [chemical binding]; other site 1232394000415 putative homodimer interface [polypeptide binding]; other site 1232394000416 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1232394000417 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232394000418 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394000419 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232394000420 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1232394000421 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1232394000422 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1232394000423 shikimate binding site; other site 1232394000424 NAD(P) binding site [chemical binding]; other site 1232394000425 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1232394000426 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1232394000427 hypothetical protein; Provisional; Region: PRK14375 1232394000428 membrane protein insertase; Provisional; Region: PRK01318 1232394000429 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1232394000430 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1232394000431 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1232394000432 putative acyl-acceptor binding pocket; other site 1232394000433 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1232394000434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1232394000435 putative acyl-acceptor binding pocket; other site 1232394000436 elongation factor P; Validated; Region: PRK00529 1232394000437 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1232394000438 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1232394000439 RNA binding site [nucleotide binding]; other site 1232394000440 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1232394000441 RNA binding site [nucleotide binding]; other site 1232394000442 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1232394000443 catalytic site [active] 1232394000444 putative active site [active] 1232394000445 putative substrate binding site [chemical binding]; other site 1232394000446 dimer interface [polypeptide binding]; other site 1232394000447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000448 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000449 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394000452 putative substrate translocation pore; other site 1232394000453 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1232394000454 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1232394000455 substrate binding pocket [chemical binding]; other site 1232394000456 membrane-bound complex binding site; other site 1232394000457 hinge residues; other site 1232394000458 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 1232394000459 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1232394000460 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1232394000461 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1232394000462 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1232394000463 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1232394000464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394000465 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394000466 putative substrate translocation pore; other site 1232394000467 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1232394000468 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1232394000469 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1232394000470 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1232394000471 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1232394000472 D-pathway; other site 1232394000473 Putative ubiquinol binding site [chemical binding]; other site 1232394000474 Low-spin heme (heme b) binding site [chemical binding]; other site 1232394000475 Putative water exit pathway; other site 1232394000476 Binuclear center (heme o3/CuB) [ion binding]; other site 1232394000477 K-pathway; other site 1232394000478 Putative proton exit pathway; other site 1232394000479 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1232394000480 Subunit I/III interface [polypeptide binding]; other site 1232394000481 Subunit III/IV interface [polypeptide binding]; other site 1232394000482 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1232394000483 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1232394000484 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232394000485 potential frameshift: common BLAST hit: gi|115314134|ref|YP_762857.1| UDP-3-[O-3-hydroxymyristoyl] glucosamine N-acyltransferase 1232394000486 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 1232394000487 pyridoxamine kinase; Validated; Region: PRK05756 1232394000488 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1232394000489 dimer interface [polypeptide binding]; other site 1232394000490 pyridoxal binding site [chemical binding]; other site 1232394000491 ATP binding site [chemical binding]; other site 1232394000492 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1232394000493 MoxR-like ATPases [General function prediction only]; Region: COG0714 1232394000494 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1232394000495 Walker A motif; other site 1232394000496 ATP binding site [chemical binding]; other site 1232394000497 Walker B motif; other site 1232394000498 arginine finger; other site 1232394000499 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1232394000500 Protein of unknown function DUF58; Region: DUF58; pfam01882 1232394000501 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1232394000502 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1232394000503 metal ion-dependent adhesion site (MIDAS); other site 1232394000504 hypothetical protein; Provisional; Region: PRK13685 1232394000505 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1232394000506 metal ion-dependent adhesion site (MIDAS); other site 1232394000507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1232394000508 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1232394000509 TPR motif; other site 1232394000510 binding surface 1232394000511 Oxygen tolerance; Region: BatD; pfam13584 1232394000512 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1232394000513 putative substrate binding pocket [chemical binding]; other site 1232394000514 AC domain interface; other site 1232394000515 catalytic triad [active] 1232394000516 AB domain interface; other site 1232394000517 interchain disulfide; other site 1232394000518 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 1232394000519 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1232394000520 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232394000521 active site 1232394000522 HIGH motif; other site 1232394000523 nucleotide binding site [chemical binding]; other site 1232394000524 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232394000525 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1232394000526 active site 1232394000527 KMSKS motif; other site 1232394000528 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1232394000529 tRNA binding surface [nucleotide binding]; other site 1232394000530 anticodon binding site; other site 1232394000531 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1232394000532 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1232394000533 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232394000534 phosphate binding site [ion binding]; other site 1232394000535 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1232394000536 dimer interface [polypeptide binding]; other site 1232394000537 FMN binding site [chemical binding]; other site 1232394000538 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1232394000539 nudix motif; other site 1232394000540 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1232394000541 Class II fumarases; Region: Fumarase_classII; cd01362 1232394000542 active site 1232394000543 tetramer interface [polypeptide binding]; other site 1232394000544 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1232394000545 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1232394000546 HIGH motif; other site 1232394000547 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1232394000548 active site 1232394000549 KMSKS motif; other site 1232394000550 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000551 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000552 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394000553 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232394000554 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1232394000555 Amidinotransferase; Region: Amidinotransf; pfam02274 1232394000556 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1232394000557 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1232394000558 folate binding site [chemical binding]; other site 1232394000559 NADP+ binding site [chemical binding]; other site 1232394000560 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1232394000561 rRNA interaction site [nucleotide binding]; other site 1232394000562 S8 interaction site; other site 1232394000563 putative laminin-1 binding site; other site 1232394000564 elongation factor Ts; Provisional; Region: tsf; PRK09377 1232394000565 UBA/TS-N domain; Region: UBA; pfam00627 1232394000566 Elongation factor TS; Region: EF_TS; pfam00889 1232394000567 Elongation factor TS; Region: EF_TS; pfam00889 1232394000568 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1232394000569 putative nucleotide binding site [chemical binding]; other site 1232394000570 uridine monophosphate binding site [chemical binding]; other site 1232394000571 homohexameric interface [polypeptide binding]; other site 1232394000572 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1232394000573 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1232394000574 hinge region; other site 1232394000575 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 1232394000576 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1232394000577 catalytic residue [active] 1232394000578 putative FPP diphosphate binding site; other site 1232394000579 putative FPP binding hydrophobic cleft; other site 1232394000580 dimer interface [polypeptide binding]; other site 1232394000581 putative IPP diphosphate binding site; other site 1232394000582 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1232394000583 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1232394000584 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1232394000585 trimer interface [polypeptide binding]; other site 1232394000586 active site 1232394000587 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1232394000588 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1232394000589 S17 interaction site [polypeptide binding]; other site 1232394000590 S8 interaction site; other site 1232394000591 16S rRNA interaction site [nucleotide binding]; other site 1232394000592 streptomycin interaction site [chemical binding]; other site 1232394000593 23S rRNA interaction site [nucleotide binding]; other site 1232394000594 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1232394000595 30S ribosomal protein S7; Validated; Region: PRK05302 1232394000596 elongation factor G; Reviewed; Region: PRK00007 1232394000597 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1232394000598 G1 box; other site 1232394000599 putative GEF interaction site [polypeptide binding]; other site 1232394000600 GTP/Mg2+ binding site [chemical binding]; other site 1232394000601 Switch I region; other site 1232394000602 G2 box; other site 1232394000603 G3 box; other site 1232394000604 Switch II region; other site 1232394000605 G4 box; other site 1232394000606 G5 box; other site 1232394000607 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1232394000608 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1232394000609 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1232394000610 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1232394000611 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1232394000612 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1232394000613 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1232394000614 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1232394000615 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1232394000616 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1232394000617 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1232394000618 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1232394000619 putative translocon binding site; other site 1232394000620 protein-rRNA interface [nucleotide binding]; other site 1232394000621 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1232394000622 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1232394000623 G-X-X-G motif; other site 1232394000624 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1232394000625 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1232394000626 23S rRNA interface [nucleotide binding]; other site 1232394000627 5S rRNA interface [nucleotide binding]; other site 1232394000628 putative antibiotic binding site [chemical binding]; other site 1232394000629 L25 interface [polypeptide binding]; other site 1232394000630 L27 interface [polypeptide binding]; other site 1232394000631 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1232394000632 23S rRNA interface [nucleotide binding]; other site 1232394000633 putative translocon interaction site; other site 1232394000634 signal recognition particle (SRP54) interaction site; other site 1232394000635 L23 interface [polypeptide binding]; other site 1232394000636 trigger factor interaction site; other site 1232394000637 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1232394000638 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1232394000639 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1232394000640 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1232394000641 RNA binding site [nucleotide binding]; other site 1232394000642 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1232394000643 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1232394000644 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1232394000645 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1232394000646 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1232394000647 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1232394000648 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1232394000649 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1232394000650 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1232394000651 23S rRNA interface [nucleotide binding]; other site 1232394000652 L21e interface [polypeptide binding]; other site 1232394000653 5S rRNA interface [nucleotide binding]; other site 1232394000654 L27 interface [polypeptide binding]; other site 1232394000655 L5 interface [polypeptide binding]; other site 1232394000656 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1232394000657 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1232394000658 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1232394000659 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1232394000660 23S rRNA binding site [nucleotide binding]; other site 1232394000661 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1232394000662 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1232394000663 SecY translocase; Region: SecY; pfam00344 1232394000664 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1232394000665 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1232394000666 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1232394000667 30S ribosomal protein S11; Validated; Region: PRK05309 1232394000668 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1232394000669 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1232394000670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232394000671 RNA binding surface [nucleotide binding]; other site 1232394000672 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1232394000673 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1232394000674 alphaNTD homodimer interface [polypeptide binding]; other site 1232394000675 alphaNTD - beta interaction site [polypeptide binding]; other site 1232394000676 alphaNTD - beta' interaction site [polypeptide binding]; other site 1232394000677 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1232394000678 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1232394000679 heat shock protein 90; Provisional; Region: PRK05218 1232394000680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232394000681 ATP binding site [chemical binding]; other site 1232394000682 Mg2+ binding site [ion binding]; other site 1232394000683 G-X-G motif; other site 1232394000684 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000687 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000688 glutamate dehydrogenase; Provisional; Region: PRK09414 1232394000689 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1232394000690 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1232394000691 NAD(P) binding site [chemical binding]; other site 1232394000692 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000693 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000694 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394000695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1232394000696 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1232394000697 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1232394000698 active site 1232394000699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232394000700 substrate binding site [chemical binding]; other site 1232394000701 catalytic residues [active] 1232394000702 dimer interface [polypeptide binding]; other site 1232394000703 Amino acid permease; Region: AA_permease_2; pfam13520 1232394000704 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1232394000705 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1232394000706 DNA binding site [nucleotide binding] 1232394000707 active site 1232394000708 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1232394000709 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1232394000710 mercuric reductase; Validated; Region: PRK06370 1232394000711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394000712 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232394000713 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1232394000714 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232394000715 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1232394000716 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1232394000717 HSP70 interaction site [polypeptide binding]; other site 1232394000718 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1232394000719 substrate binding site [polypeptide binding]; other site 1232394000720 dimer interface [polypeptide binding]; other site 1232394000721 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1232394000722 EamA-like transporter family; Region: EamA; pfam00892 1232394000723 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232394000724 Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271 1232394000725 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1232394000726 HD domain; Region: HD_4; pfam13328 1232394000727 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1232394000728 synthetase active site [active] 1232394000729 NTP binding site [chemical binding]; other site 1232394000730 metal binding site [ion binding]; metal-binding site 1232394000731 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1232394000732 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1232394000733 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1232394000734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394000735 S-adenosylmethionine binding site [chemical binding]; other site 1232394000736 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1232394000737 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232394000738 active site 1232394000739 DNA binding site [nucleotide binding] 1232394000740 Int/Topo IB signature motif; other site 1232394000741 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1232394000742 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232394000743 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1232394000744 preprotein translocase subunit SecB; Validated; Region: PRK05751 1232394000745 SecA binding site; other site 1232394000746 Preprotein binding site; other site 1232394000747 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1232394000748 MutS domain I; Region: MutS_I; pfam01624 1232394000749 MutS domain III; Region: MutS_III; pfam05192 1232394000750 MutS domain V; Region: MutS_V; pfam00488 1232394000751 Walker A/P-loop; other site 1232394000752 ATP binding site [chemical binding]; other site 1232394000753 Q-loop/lid; other site 1232394000754 ABC transporter signature motif; other site 1232394000755 Walker B; other site 1232394000756 D-loop; other site 1232394000757 H-loop/switch region; other site 1232394000758 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1232394000759 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1232394000760 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1232394000761 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1232394000762 putative active site [active] 1232394000763 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 1232394000764 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000765 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1232394000767 Zeta toxin; Region: Zeta_toxin; pfam06414 1232394000768 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232394000769 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1232394000770 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1232394000771 active site 1232394000772 HIGH motif; other site 1232394000773 dimer interface [polypeptide binding]; other site 1232394000774 KMSKS motif; other site 1232394000775 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1232394000776 dephospho-CoA kinase; Region: TIGR00152 1232394000777 CoA-binding site [chemical binding]; other site 1232394000778 ATP-binding [chemical binding]; other site 1232394000779 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1232394000780 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1232394000781 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1232394000782 dimer interface [polypeptide binding]; other site 1232394000783 TPP-binding site [chemical binding]; other site 1232394000784 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1232394000785 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232394000786 E3 interaction surface; other site 1232394000787 lipoyl attachment site [posttranslational modification]; other site 1232394000788 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232394000789 E3 interaction surface; other site 1232394000790 lipoyl attachment site [posttranslational modification]; other site 1232394000791 e3 binding domain; Region: E3_binding; pfam02817 1232394000792 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232394000793 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1232394000794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232394000795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394000796 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232394000797 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1232394000798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000799 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000800 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000802 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1232394000803 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1232394000804 nudix motif; other site 1232394000805 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 1232394000806 ArsC family; Region: ArsC; pfam03960 1232394000807 catalytic residue [active] 1232394000808 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1232394000809 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1232394000810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232394000811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394000812 homodimer interface [polypeptide binding]; other site 1232394000813 catalytic residue [active] 1232394000814 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1232394000815 TrkA-C domain; Region: TrkA_C; pfam02080 1232394000816 TrkA-C domain; Region: TrkA_C; pfam02080 1232394000817 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1232394000818 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1232394000819 DNA protecting protein DprA; Region: dprA; TIGR00732 1232394000820 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1232394000821 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1232394000822 ligand binding site [chemical binding]; other site 1232394000823 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1232394000824 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232394000825 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1232394000826 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1232394000827 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1232394000828 homotrimer interaction site [polypeptide binding]; other site 1232394000829 active site 1232394000830 potential frameshift: common BLAST hit: gi|187931250|ref|YP_001891234.1| phosphatidylserine synthase 1232394000831 TolQ protein; Region: tolQ; TIGR02796 1232394000832 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1232394000833 TolR protein; Region: tolR; TIGR02801 1232394000834 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1232394000835 TolB amino-terminal domain; Region: TolB_N; pfam04052 1232394000836 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1232394000837 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1232394000838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1232394000839 ligand binding site [chemical binding]; other site 1232394000840 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1232394000841 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1232394000842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394000843 FeS/SAM binding site; other site 1232394000844 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232394000845 Coenzyme A binding pocket [chemical binding]; other site 1232394000846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000847 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000848 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000850 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1232394000851 DNA photolyase; Region: DNA_photolyase; pfam00875 1232394000852 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1232394000853 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1232394000854 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1232394000855 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1232394000856 bile acid transporter; Region: bass; TIGR00841 1232394000857 Sodium Bile acid symporter family; Region: SBF; cl17470 1232394000858 YheO-like PAS domain; Region: PAS_6; pfam08348 1232394000859 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1232394000860 potential frameshift: common BLAST hit: gi|385794610|ref|YP_005831016.1| arsenite permease family protein 1232394000861 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1232394000862 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394000863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394000864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394000865 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394000866 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1232394000867 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 1232394000868 UbiA prenyltransferase family; Region: UbiA; pfam01040 1232394000869 Chorismate lyase; Region: Chor_lyase; cl01230 1232394000870 ribonuclease PH; Reviewed; Region: rph; PRK00173 1232394000871 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1232394000872 hexamer interface [polypeptide binding]; other site 1232394000873 active site 1232394000874 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1232394000875 heat shock protein HtpX; Provisional; Region: PRK02870 1232394000876 LemA family; Region: LemA; cl00742 1232394000877 potential frameshift: common BLAST hit: gi|385794621|ref|YP_005831027.1| LysR family transcriptional regulator 1232394000878 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1232394000879 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232394000880 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000882 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394000883 potential frameshift: common BLAST hit: gi|118497001|ref|YP_898051.1| heavy metal cation transport ATPase 1232394000884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232394000885 dimerization interface [polypeptide binding]; other site 1232394000886 putative DNA binding site [nucleotide binding]; other site 1232394000887 putative Zn2+ binding site [ion binding]; other site 1232394000888 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1232394000889 putative active site [active] 1232394000890 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1232394000891 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1232394000892 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1232394000893 Colicin V production protein; Region: Colicin_V; pfam02674 1232394000894 DNA repair protein RadA; Provisional; Region: PRK11823 1232394000895 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1232394000896 Walker A motif/ATP binding site; other site 1232394000897 ATP binding site [chemical binding]; other site 1232394000898 Walker B motif; other site 1232394000899 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1232394000900 PilZ domain; Region: PilZ; pfam07238 1232394000901 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232394000902 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232394000903 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1232394000904 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1232394000905 Tetramer interface [polypeptide binding]; other site 1232394000906 active site 1232394000907 FMN-binding site [chemical binding]; other site 1232394000908 PQ loop repeat; Region: PQ-loop; pfam04193 1232394000909 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1232394000910 SelR domain; Region: SelR; pfam01641 1232394000911 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1232394000912 E-class dimer interface [polypeptide binding]; other site 1232394000913 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1232394000914 P-class dimer interface [polypeptide binding]; other site 1232394000915 active site 1232394000916 Cu2+ binding site [ion binding]; other site 1232394000917 Zn2+ binding site [ion binding]; other site 1232394000918 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1232394000919 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1232394000920 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1232394000921 Cupin domain; Region: Cupin_2; cl17218 1232394000922 potential frameshift: common BLAST hit: gi|118497016|ref|YP_898066.1| Zn-dependent alcohol dehydrogenase 1232394000923 potential frameshift: common BLAST hit: gi|187931286|ref|YP_001891270.1| Zn-dependent alcohol dehydrogenase 1232394000924 aspartate aminotransferase; Provisional; Region: PRK07568 1232394000925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232394000926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394000927 homodimer interface [polypeptide binding]; other site 1232394000928 catalytic residue [active] 1232394000929 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232394000930 Cation efflux family; Region: Cation_efflux; pfam01545 1232394000931 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1232394000932 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1232394000933 Walker A/P-loop; other site 1232394000934 ATP binding site [chemical binding]; other site 1232394000935 Q-loop/lid; other site 1232394000936 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1232394000937 ABC transporter signature motif; other site 1232394000938 Walker B; other site 1232394000939 D-loop; other site 1232394000940 H-loop/switch region; other site 1232394000941 potential frameshift: common BLAST hit: gi|385794642|ref|YP_005831048.1| Type IV pili fiber building block protein 1232394000942 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1232394000943 Pilin (bacterial filament); Region: Pilin; pfam00114 1232394000944 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 1232394000945 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1232394000946 active site 1232394000947 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14180 1232394000948 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1232394000949 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1232394000950 homodimer interface [polypeptide binding]; other site 1232394000951 NADP binding site [chemical binding]; other site 1232394000952 substrate binding site [chemical binding]; other site 1232394000953 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1232394000954 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1232394000955 dimerization interface [polypeptide binding]; other site 1232394000956 putative ATP binding site [chemical binding]; other site 1232394000957 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1232394000958 active site 1232394000959 ATP binding site [chemical binding]; other site 1232394000960 substrate binding site [chemical binding]; other site 1232394000961 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1232394000962 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1232394000963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232394000964 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1232394000965 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1232394000966 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1232394000967 active site 1232394000968 substrate binding site [chemical binding]; other site 1232394000969 cosubstrate binding site; other site 1232394000970 catalytic site [active] 1232394000971 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1232394000972 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1232394000973 ATP-grasp domain; Region: ATP-grasp; pfam02222 1232394000974 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394000975 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394000976 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394000977 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1232394000978 intracellular septation protein A; Reviewed; Region: PRK00259 1232394000979 Glucokinase; Region: Glucokinase; pfam02685 1232394000980 glucokinase, proteobacterial type; Region: glk; TIGR00749 1232394000981 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1232394000982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394000983 S-adenosylmethionine binding site [chemical binding]; other site 1232394000984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1232394000985 ABC1 family; Region: ABC1; cl17513 1232394000986 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1232394000987 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1232394000988 nucleotide binding site/active site [active] 1232394000989 HIT family signature motif; other site 1232394000990 catalytic residue [active] 1232394000991 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1232394000992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394000993 active site 1232394000994 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1232394000995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232394000996 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1232394000997 FAD binding domain; Region: FAD_binding_4; pfam01565 1232394000998 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1232394000999 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1232394001000 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1232394001001 putative active site [active] 1232394001002 GTP-binding protein Der; Reviewed; Region: PRK00093 1232394001003 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1232394001004 G1 box; other site 1232394001005 GTP/Mg2+ binding site [chemical binding]; other site 1232394001006 Switch I region; other site 1232394001007 G2 box; other site 1232394001008 Switch II region; other site 1232394001009 G3 box; other site 1232394001010 G4 box; other site 1232394001011 G5 box; other site 1232394001012 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1232394001013 G1 box; other site 1232394001014 GTP/Mg2+ binding site [chemical binding]; other site 1232394001015 Switch I region; other site 1232394001016 G2 box; other site 1232394001017 G3 box; other site 1232394001018 Switch II region; other site 1232394001019 G4 box; other site 1232394001020 G5 box; other site 1232394001021 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001022 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001023 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001024 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001025 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001027 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001028 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1232394001029 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1232394001030 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1232394001031 active site 1232394001032 Zn binding site [ion binding]; other site 1232394001033 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1232394001034 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1232394001035 DNA topoisomerase I; Validated; Region: PRK06599 1232394001036 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1232394001037 active site 1232394001038 interdomain interaction site; other site 1232394001039 putative metal-binding site [ion binding]; other site 1232394001040 nucleotide binding site [chemical binding]; other site 1232394001041 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1232394001042 domain I; other site 1232394001043 DNA binding groove [nucleotide binding] 1232394001044 phosphate binding site [ion binding]; other site 1232394001045 domain II; other site 1232394001046 domain III; other site 1232394001047 nucleotide binding site [chemical binding]; other site 1232394001048 catalytic site [active] 1232394001049 domain IV; other site 1232394001050 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1232394001051 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1232394001052 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1232394001053 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1232394001054 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1232394001055 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1232394001056 P-loop; other site 1232394001057 Magnesium ion binding site [ion binding]; other site 1232394001058 ParB-like nuclease domain; Region: ParB; smart00470 1232394001059 KorB domain; Region: KorB; pfam08535 1232394001060 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1232394001061 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1232394001062 catalytic triad [active] 1232394001063 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1232394001064 active site 1232394001065 catalytic triad [active] 1232394001066 oxyanion hole [active] 1232394001067 potential frameshift: common BLAST hit: gi|385794665|ref|YP_005831071.1| metal-dependent phosphohydrolase 1232394001068 FtsJ-like methyltransferase; Region: FtsJ; cl17430 1232394001069 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1232394001070 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1232394001071 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1232394001072 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232394001073 active site 1232394001074 HIGH motif; other site 1232394001075 nucleotide binding site [chemical binding]; other site 1232394001076 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232394001077 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1232394001078 active site 1232394001079 KMSKS motif; other site 1232394001080 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1232394001081 tRNA binding surface [nucleotide binding]; other site 1232394001082 anticodon binding site; other site 1232394001083 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232394001084 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1232394001085 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1232394001086 active site 1232394001087 Riboflavin kinase; Region: Flavokinase; pfam01687 1232394001088 potential frameshift: common BLAST hit: gi|156501828|ref|YP_001427893.1| malate dehydrogenase 1232394001089 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1232394001090 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1232394001091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001092 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001093 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001095 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001096 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001097 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001098 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1232394001099 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1232394001100 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1232394001101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394001102 D-galactonate transporter; Region: 2A0114; TIGR00893 1232394001103 putative substrate translocation pore; other site 1232394001104 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1232394001105 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1232394001106 active site 1232394001107 HIGH motif; other site 1232394001108 KMSKS motif; other site 1232394001109 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1232394001110 tRNA binding surface [nucleotide binding]; other site 1232394001111 anticodon binding site; other site 1232394001112 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1232394001113 dimer interface [polypeptide binding]; other site 1232394001114 putative tRNA-binding site [nucleotide binding]; other site 1232394001115 Predicted flavoprotein [General function prediction only]; Region: COG0431 1232394001116 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232394001117 potential frameshift: common BLAST hit: gi|379726236|ref|YP_005318422.1| Gentisate 1 2-dioxygenase 1232394001118 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 1232394001119 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1232394001120 Peptidase family M50; Region: Peptidase_M50; pfam02163 1232394001121 active site 1232394001122 putative substrate binding region [chemical binding]; other site 1232394001123 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1232394001124 DNA binding residues [nucleotide binding] 1232394001125 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1232394001126 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 1232394001127 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168 1232394001128 active site 1232394001129 (T/H)XGH motif; other site 1232394001130 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1232394001131 nudix motif; other site 1232394001132 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1232394001133 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1232394001134 Substrate binding site; other site 1232394001135 Mg++ binding site; other site 1232394001136 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1232394001137 active site 1232394001138 substrate binding site [chemical binding]; other site 1232394001139 CoA binding site [chemical binding]; other site 1232394001140 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1232394001141 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1232394001142 glutaminase active site [active] 1232394001143 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1232394001144 dimer interface [polypeptide binding]; other site 1232394001145 active site 1232394001146 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1232394001147 dimer interface [polypeptide binding]; other site 1232394001148 active site 1232394001149 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1232394001150 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1232394001151 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232394001152 DNA-binding site [nucleotide binding]; DNA binding site 1232394001153 RNA-binding motif; other site 1232394001154 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1232394001155 metal binding site [ion binding]; metal-binding site 1232394001156 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1232394001157 active site 1232394001158 PLD-like domain; Region: PLDc_2; pfam13091 1232394001159 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 1232394001160 putative homodimer interface [polypeptide binding]; other site 1232394001161 putative active site [active] 1232394001162 catalytic site [active] 1232394001163 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1232394001164 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1232394001165 CAP-like domain; other site 1232394001166 active site 1232394001167 primary dimer interface [polypeptide binding]; other site 1232394001168 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1232394001169 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1232394001170 BNR repeat-like domain; Region: BNR_2; pfam13088 1232394001171 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1232394001172 Asp-box motif; other site 1232394001173 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1232394001174 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232394001175 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232394001176 catalytic residue [active] 1232394001177 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1232394001178 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001179 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001180 Predicted membrane protein [Function unknown]; Region: COG4325 1232394001181 Predicted membrane protein [Function unknown]; Region: COG4325 1232394001182 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1232394001183 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1232394001184 putative active site [active] 1232394001185 putative PHP Thumb interface [polypeptide binding]; other site 1232394001186 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1232394001187 generic binding surface II; other site 1232394001188 generic binding surface I; other site 1232394001189 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1232394001190 active site 1232394001191 catalytic residues [active] 1232394001192 metal binding site [ion binding]; metal-binding site 1232394001193 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1232394001194 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1232394001195 FtsX-like permease family; Region: FtsX; pfam02687 1232394001196 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1232394001197 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1232394001198 Walker A/P-loop; other site 1232394001199 ATP binding site [chemical binding]; other site 1232394001200 Q-loop/lid; other site 1232394001201 ABC transporter signature motif; other site 1232394001202 Walker B; other site 1232394001203 D-loop; other site 1232394001204 H-loop/switch region; other site 1232394001205 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1232394001206 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1232394001207 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1232394001208 homodimer interface [polypeptide binding]; other site 1232394001209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394001210 catalytic residue [active] 1232394001211 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1232394001212 potential frameshift: common BLAST hit: gi|156501870|ref|YP_001427935.1| glycine cleavage system aminomethyltransferase T 1232394001213 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1232394001214 lipoyl attachment site [posttranslational modification]; other site 1232394001215 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1232394001216 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1232394001217 tetramer interface [polypeptide binding]; other site 1232394001218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394001219 catalytic residue [active] 1232394001220 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1232394001221 tetramer interface [polypeptide binding]; other site 1232394001222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394001223 catalytic residue [active] 1232394001224 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1232394001225 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1232394001226 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1232394001227 shikimate binding site; other site 1232394001228 NAD(P) binding site [chemical binding]; other site 1232394001229 pullulanase, type I; Region: pulA_typeI; TIGR02104 1232394001230 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1232394001231 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1232394001232 Ca binding site [ion binding]; other site 1232394001233 active site 1232394001234 catalytic site [active] 1232394001235 glycogen branching enzyme; Provisional; Region: PRK12313 1232394001236 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1232394001237 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1232394001238 active site 1232394001239 catalytic site [active] 1232394001240 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1232394001241 phosphoglucomutase; Region: PLN02307 1232394001242 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 1232394001243 substrate binding site [chemical binding]; other site 1232394001244 dimer interface [polypeptide binding]; other site 1232394001245 active site 1232394001246 metal binding site [ion binding]; metal-binding site 1232394001247 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1232394001248 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1232394001249 ligand binding site; other site 1232394001250 oligomer interface; other site 1232394001251 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1232394001252 dimer interface [polypeptide binding]; other site 1232394001253 N-terminal domain interface [polypeptide binding]; other site 1232394001254 sulfate 1 binding site; other site 1232394001255 glycogen synthase; Provisional; Region: glgA; PRK00654 1232394001256 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1232394001257 ADP-binding pocket [chemical binding]; other site 1232394001258 homodimer interface [polypeptide binding]; other site 1232394001259 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232394001260 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1232394001261 potential frameshift: common BLAST hit: gi|115314386|ref|YP_763109.1| 4-alpha-glucanotransferase 1232394001262 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1232394001263 dimer interface [polypeptide binding]; other site 1232394001264 motif 1; other site 1232394001265 active site 1232394001266 motif 2; other site 1232394001267 motif 3; other site 1232394001268 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1232394001269 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232394001270 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394001271 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232394001272 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1232394001273 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232394001274 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1232394001275 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394001276 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1232394001277 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1232394001278 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1232394001279 nucleotide binding site [chemical binding]; other site 1232394001280 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1232394001281 dimer interface [polypeptide binding]; other site 1232394001282 putative threonine allosteric regulatory site; other site 1232394001283 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1232394001284 homoserine kinase; Provisional; Region: PRK01212 1232394001285 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1232394001286 threonine synthase; Validated; Region: PRK09225 1232394001287 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1232394001288 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394001289 catalytic residue [active] 1232394001290 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1232394001291 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1232394001292 spermidine synthase; Provisional; Region: PRK00811 1232394001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394001294 arginine decarboxylase; Provisional; Region: PRK05354 1232394001295 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1232394001296 active site 1232394001297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232394001298 dimer interface [polypeptide binding]; other site 1232394001299 substrate binding site [chemical binding]; other site 1232394001300 catalytic residues [active] 1232394001301 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1232394001302 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001305 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001306 potential frameshift: common BLAST hit: gi|385794201|ref|YP_005830607.1| carbon-nitrogen hydrolase family protein 1232394001307 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1232394001308 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1232394001309 putative active site [active] 1232394001310 putative metal binding site [ion binding]; other site 1232394001311 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1232394001312 metal binding site [ion binding]; metal-binding site 1232394001313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394001314 active site 1232394001315 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1232394001316 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1232394001317 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394001318 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232394001319 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1232394001320 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232394001321 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001324 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001325 BolA-like protein; Region: BolA; cl00386 1232394001326 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1232394001327 anti sigma factor interaction site; other site 1232394001328 regulatory phosphorylation site [posttranslational modification]; other site 1232394001329 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1232394001330 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232394001331 mce related protein; Region: MCE; pfam02470 1232394001332 Permease; Region: Permease; pfam02405 1232394001333 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232394001334 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1232394001335 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1232394001336 Walker A/P-loop; other site 1232394001337 ATP binding site [chemical binding]; other site 1232394001338 Q-loop/lid; other site 1232394001339 ABC transporter signature motif; other site 1232394001340 Walker B; other site 1232394001341 D-loop; other site 1232394001342 H-loop/switch region; other site 1232394001343 cell division topological specificity factor MinE; Provisional; Region: PRK13990 1232394001344 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1232394001345 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1232394001346 Switch I; other site 1232394001347 Switch II; other site 1232394001348 septum formation inhibitor; Reviewed; Region: minC; PRK04804 1232394001349 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1232394001350 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1232394001351 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1232394001352 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1232394001353 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1232394001354 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1232394001355 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1232394001356 ssDNA binding site; other site 1232394001357 generic binding surface II; other site 1232394001358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394001359 ATP binding site [chemical binding]; other site 1232394001360 putative Mg++ binding site [ion binding]; other site 1232394001361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394001362 nucleotide binding region [chemical binding]; other site 1232394001363 ATP-binding site [chemical binding]; other site 1232394001364 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1232394001365 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1232394001366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001367 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001368 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1232394001369 GIY-YIG motif/motif A; other site 1232394001370 putative active site [active] 1232394001371 putative metal binding site [ion binding]; other site 1232394001372 Restriction endonuclease [Defense mechanisms]; Region: COG3587 1232394001373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394001374 ATP binding site [chemical binding]; other site 1232394001375 putative Mg++ binding site [ion binding]; other site 1232394001376 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1232394001377 ligand binding site [chemical binding]; other site 1232394001378 active site 1232394001379 UGI interface [polypeptide binding]; other site 1232394001380 catalytic site [active] 1232394001381 potential frameshift: common BLAST hit: gi|118498056|ref|YP_899106.1| chitin-binding protein 1232394001382 potential frameshift: common BLAST hit: gi|118498056|ref|YP_899106.1| chitin-binding protein 1232394001383 DNA gyrase subunit A; Validated; Region: PRK05560 1232394001384 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1232394001385 CAP-like domain; other site 1232394001386 active site 1232394001387 primary dimer interface [polypeptide binding]; other site 1232394001388 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232394001389 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232394001390 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232394001391 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232394001392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232394001393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1232394001394 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1232394001395 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1232394001396 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1232394001397 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1232394001398 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1232394001399 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1232394001400 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1232394001401 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1232394001402 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1232394001403 Surface antigen; Region: Bac_surface_Ag; pfam01103 1232394001404 periplasmic chaperone; Provisional; Region: PRK10780 1232394001405 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1232394001406 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1232394001407 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1232394001408 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1232394001409 trimer interface [polypeptide binding]; other site 1232394001410 active site 1232394001411 UDP-GlcNAc binding site [chemical binding]; other site 1232394001412 lipid binding site [chemical binding]; lipid-binding site 1232394001413 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1232394001414 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1232394001415 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1232394001416 active site 1232394001417 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1232394001418 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1232394001419 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1232394001420 active site 1232394001421 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1232394001422 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1232394001423 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1232394001424 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1232394001425 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1232394001426 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232394001427 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232394001428 substrate binding pocket [chemical binding]; other site 1232394001429 chain length determination region; other site 1232394001430 substrate-Mg2+ binding site; other site 1232394001431 catalytic residues [active] 1232394001432 aspartate-rich region 1; other site 1232394001433 active site lid residues [active] 1232394001434 aspartate-rich region 2; other site 1232394001435 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1232394001436 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1232394001437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1232394001438 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1232394001439 active site 1232394001440 dimerization interface [polypeptide binding]; other site 1232394001441 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1232394001442 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1232394001443 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1232394001444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1232394001445 active site 1232394001446 phosphorylation site [posttranslational modification] 1232394001447 intermolecular recognition site; other site 1232394001448 dimerization interface [polypeptide binding]; other site 1232394001449 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232394001450 DNA binding site [nucleotide binding] 1232394001451 signal peptidase I; Provisional; Region: PRK10861 1232394001452 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1232394001453 Catalytic site [active] 1232394001454 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1232394001455 ribonuclease III; Reviewed; Region: rnc; PRK00102 1232394001456 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1232394001457 dimerization interface [polypeptide binding]; other site 1232394001458 active site 1232394001459 metal binding site [ion binding]; metal-binding site 1232394001460 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1232394001461 dsRNA binding site [nucleotide binding]; other site 1232394001462 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1232394001463 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1232394001464 RNA binding site [nucleotide binding]; other site 1232394001465 active site 1232394001466 ribonuclease R; Region: RNase_R; TIGR02063 1232394001467 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1232394001468 RNB domain; Region: RNB; pfam00773 1232394001469 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1232394001470 RNA binding site [nucleotide binding]; other site 1232394001471 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1232394001472 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1232394001473 Di-iron ligands [ion binding]; other site 1232394001474 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1232394001475 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1232394001476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394001477 NAD(P) binding site [chemical binding]; other site 1232394001478 active site 1232394001479 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 1232394001480 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1232394001481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394001482 S-adenosylmethionine binding site [chemical binding]; other site 1232394001483 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1232394001484 potential frameshift: common BLAST hit: gi|118498025|ref|YP_899075.1| two-component regulator, sensor histidine kinase 1232394001485 potential frameshift: common BLAST hit: gi|134301472|ref|YP_001121440.1| two-component system sensor histidine kinase 1232394001486 potential frameshift: common BLAST hit: gi|385795264|ref|YP_005831670.1| two component response regulator 1232394001487 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001488 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001489 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001490 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 1232394001491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1232394001492 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001493 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001494 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001495 ornithine cyclodeaminase; Validated; Region: PRK07589 1232394001496 ornithine cyclodeaminase; Validated; Region: PRK07589 1232394001497 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1232394001498 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1232394001499 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1232394001500 active site 1232394001501 Protein of unknown function (DUF465); Region: DUF465; pfam04325 1232394001502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394001503 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1232394001504 putative substrate translocation pore; other site 1232394001505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1232394001506 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1232394001507 CoenzymeA binding site [chemical binding]; other site 1232394001508 subunit interaction site [polypeptide binding]; other site 1232394001509 PHB binding site; other site 1232394001510 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1232394001511 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1232394001512 dimer interface [polypeptide binding]; other site 1232394001513 active site 1232394001514 potential frameshift: common BLAST hit: gi|156501985|ref|YP_001428050.1| fusion product of 3-hydroxacyl-CoA dehydrogenase and 1232394001515 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1232394001516 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1232394001517 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1232394001518 active site 1232394001519 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1232394001520 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1232394001521 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232394001522 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232394001523 acyl-activating enzyme (AAE) consensus motif; other site 1232394001524 AMP binding site [chemical binding]; other site 1232394001525 active site 1232394001526 CoA binding site [chemical binding]; other site 1232394001527 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1232394001528 ArsC family; Region: ArsC; pfam03960 1232394001529 catalytic residues [active] 1232394001530 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1232394001531 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1232394001532 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1232394001533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394001534 ATP binding site [chemical binding]; other site 1232394001535 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1232394001536 putative Mg++ binding site [ion binding]; other site 1232394001537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394001538 nucleotide binding region [chemical binding]; other site 1232394001539 ATP-binding site [chemical binding]; other site 1232394001540 Helicase associated domain (HA2); Region: HA2; pfam04408 1232394001541 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1232394001542 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1232394001543 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1232394001544 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001545 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001546 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001547 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1232394001548 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1232394001549 NAD(P) binding site [chemical binding]; other site 1232394001550 homodimer interface [polypeptide binding]; other site 1232394001551 substrate binding site [chemical binding]; other site 1232394001552 active site 1232394001553 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1232394001554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394001555 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1232394001556 NAD(P) binding site [chemical binding]; other site 1232394001557 active site 1232394001558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232394001559 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1232394001560 putative ADP-binding pocket [chemical binding]; other site 1232394001561 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1232394001562 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1232394001563 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1232394001564 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1232394001565 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1232394001566 NAD binding site [chemical binding]; other site 1232394001567 substrate binding site [chemical binding]; other site 1232394001568 homodimer interface [polypeptide binding]; other site 1232394001569 active site 1232394001570 potential frameshift: common BLAST hit: gi|156501999|ref|YP_001428064.1| O-antigen polymerase 1232394001571 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232394001572 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1232394001573 putative ADP-binding pocket [chemical binding]; other site 1232394001574 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1232394001575 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1232394001576 active site 1232394001577 dimer interface [polypeptide binding]; other site 1232394001578 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1232394001579 Ligand Binding Site [chemical binding]; other site 1232394001580 Molecular Tunnel; other site 1232394001581 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1232394001582 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1232394001583 inhibitor-cofactor binding pocket; inhibition site 1232394001584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394001585 catalytic residue [active] 1232394001586 hypothetical protein; Provisional; Region: PRK07579 1232394001587 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1232394001588 active site 1232394001589 cosubstrate binding site; other site 1232394001590 substrate binding site [chemical binding]; other site 1232394001591 catalytic site [active] 1232394001592 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1232394001593 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1232394001594 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1232394001595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232394001596 active site 1232394001597 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1232394001598 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1232394001599 substrate binding site; other site 1232394001600 tetramer interface; other site 1232394001601 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1232394001602 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1232394001603 NAD binding site [chemical binding]; other site 1232394001604 substrate binding site [chemical binding]; other site 1232394001605 homodimer interface [polypeptide binding]; other site 1232394001606 active site 1232394001607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001608 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001609 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001611 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1232394001612 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1232394001613 Substrate binding site; other site 1232394001614 Cupin domain; Region: Cupin_2; cl17218 1232394001615 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1232394001616 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1232394001617 active site 1232394001618 substrate binding site [chemical binding]; other site 1232394001619 metal binding site [ion binding]; metal-binding site 1232394001620 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1232394001621 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1232394001622 multimer interface [polypeptide binding]; other site 1232394001623 Walker A motif; other site 1232394001624 ATP binding site [chemical binding]; other site 1232394001625 Walker B motif; other site 1232394001626 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232394001627 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232394001628 catalytic residues [active] 1232394001629 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1232394001630 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1232394001631 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001632 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001633 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001634 recombination factor protein RarA; Provisional; Region: PRK14700 1232394001635 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1232394001636 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1232394001637 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1232394001638 dimer interface [polypeptide binding]; other site 1232394001639 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1232394001640 Ferritin-like domain; Region: Ferritin; pfam00210 1232394001641 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1232394001642 dinuclear metal binding motif [ion binding]; other site 1232394001643 potential frameshift: common BLAST hit: gi|118497983|ref|YP_899033.1| major facilitator transporter 1232394001644 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1232394001645 active site 1232394001646 Cupin domain; Region: Cupin_2; cl17218 1232394001647 hypothetical protein; Provisional; Region: PRK10621 1232394001648 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232394001649 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001650 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001651 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001652 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232394001653 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1232394001654 Walker A/P-loop; other site 1232394001655 ATP binding site [chemical binding]; other site 1232394001656 Q-loop/lid; other site 1232394001657 ABC transporter signature motif; other site 1232394001658 Walker B; other site 1232394001659 D-loop; other site 1232394001660 H-loop/switch region; other site 1232394001661 inner membrane transport permease; Provisional; Region: PRK15066 1232394001662 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232394001663 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1232394001664 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1232394001665 Ligand binding site; other site 1232394001666 Putative Catalytic site; other site 1232394001667 DXD motif; other site 1232394001668 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1232394001669 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1232394001670 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1232394001671 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1232394001672 potential frameshift: common BLAST hit: gi|385795143|ref|YP_005831549.1| Acetyltransferase 1232394001673 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001676 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232394001678 putative DNA binding site [nucleotide binding]; other site 1232394001679 putative Zn2+ binding site [ion binding]; other site 1232394001680 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232394001681 active site residue [active] 1232394001682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232394001683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394001684 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232394001685 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1232394001686 active site residue [active] 1232394001687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232394001688 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232394001689 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1232394001690 hypothetical protein; Provisional; Region: PRK05170 1232394001691 transcription antitermination factor NusB; Region: nusB; TIGR01951 1232394001692 putative RNA binding site [nucleotide binding]; other site 1232394001693 C-N hydrolase family amidase; Provisional; Region: PRK10438 1232394001694 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1232394001695 putative active site [active] 1232394001696 catalytic triad [active] 1232394001697 dimer interface [polypeptide binding]; other site 1232394001698 multimer interface [polypeptide binding]; other site 1232394001699 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1232394001700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232394001701 homodimer interface [polypeptide binding]; other site 1232394001702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394001703 catalytic residue [active] 1232394001704 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232394001705 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1232394001706 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1232394001707 dimer interface [polypeptide binding]; other site 1232394001708 motif 1; other site 1232394001709 active site 1232394001710 motif 2; other site 1232394001711 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1232394001712 putative deacylase active site [active] 1232394001713 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232394001714 active site 1232394001715 motif 3; other site 1232394001716 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1232394001717 anticodon binding site; other site 1232394001718 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1232394001719 nucleic acid binding site [nucleotide binding]; other site 1232394001720 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1232394001721 Fe-S metabolism associated domain; Region: SufE; cl00951 1232394001722 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1232394001723 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1232394001724 active site 1232394001725 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232394001726 Sporulation related domain; Region: SPOR; pfam05036 1232394001727 FeoA domain; Region: FeoA; cl00838 1232394001728 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1232394001729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232394001730 non-specific DNA binding site [nucleotide binding]; other site 1232394001731 salt bridge; other site 1232394001732 sequence-specific DNA binding site [nucleotide binding]; other site 1232394001733 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1232394001734 Catalytic site [active] 1232394001735 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1232394001736 EamA-like transporter family; Region: EamA; pfam00892 1232394001737 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1232394001738 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1232394001739 active site 1232394001740 FMN binding site [chemical binding]; other site 1232394001741 substrate binding site [chemical binding]; other site 1232394001742 3Fe-4S cluster binding site [ion binding]; other site 1232394001743 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1232394001744 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1232394001745 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232394001746 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1232394001747 Divergent AAA domain; Region: AAA_4; pfam04326 1232394001748 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1232394001749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232394001750 putative DNA binding site [nucleotide binding]; other site 1232394001751 putative Zn2+ binding site [ion binding]; other site 1232394001752 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1232394001753 Family description; Region: UvrD_C_2; pfam13538 1232394001754 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1232394001755 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1232394001756 AAA domain; Region: AAA_30; pfam13604 1232394001757 Family description; Region: UvrD_C_2; pfam13538 1232394001758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1232394001759 nucleotide binding site [chemical binding]; other site 1232394001760 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1232394001761 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1232394001762 tetramerization interface [polypeptide binding]; other site 1232394001763 active site 1232394001764 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232394001765 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1232394001766 active site 1232394001767 nucleotide binding site [chemical binding]; other site 1232394001768 HIGH motif; other site 1232394001769 KMSKS motif; other site 1232394001770 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1232394001771 active site 1232394001772 oligomerization interface [polypeptide binding]; other site 1232394001773 metal binding site [ion binding]; metal-binding site 1232394001774 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1232394001775 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1232394001776 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1232394001777 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1232394001778 nucleotide binding pocket [chemical binding]; other site 1232394001779 K-X-D-G motif; other site 1232394001780 catalytic site [active] 1232394001781 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1232394001782 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1232394001783 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1232394001784 Dimer interface [polypeptide binding]; other site 1232394001785 BRCT sequence motif; other site 1232394001786 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1232394001787 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001790 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001791 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1232394001792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232394001793 dimer interface [polypeptide binding]; other site 1232394001794 conserved gate region; other site 1232394001795 putative PBP binding loops; other site 1232394001796 ABC-ATPase subunit interface; other site 1232394001797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232394001798 dimer interface [polypeptide binding]; other site 1232394001799 conserved gate region; other site 1232394001800 putative PBP binding loops; other site 1232394001801 ABC-ATPase subunit interface; other site 1232394001802 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1232394001803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394001804 Walker A/P-loop; other site 1232394001805 ATP binding site [chemical binding]; other site 1232394001806 Q-loop/lid; other site 1232394001807 ABC transporter signature motif; other site 1232394001808 Walker B; other site 1232394001809 D-loop; other site 1232394001810 H-loop/switch region; other site 1232394001811 TOBE domain; Region: TOBE_2; pfam08402 1232394001812 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001815 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001816 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1232394001817 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1232394001818 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232394001819 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1232394001820 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1232394001821 homodimer interface [polypeptide binding]; other site 1232394001822 NAD binding pocket [chemical binding]; other site 1232394001823 ATP binding pocket [chemical binding]; other site 1232394001824 Mg binding site [ion binding]; other site 1232394001825 active-site loop [active] 1232394001826 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1232394001827 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1232394001828 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1232394001829 HlyD family secretion protein; Region: HlyD_3; pfam13437 1232394001830 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1232394001831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394001832 putative substrate translocation pore; other site 1232394001833 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1232394001834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1232394001835 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1232394001836 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1232394001837 acyl-activating enzyme (AAE) consensus motif; other site 1232394001838 putative AMP binding site [chemical binding]; other site 1232394001839 putative active site [active] 1232394001840 putative CoA binding site [chemical binding]; other site 1232394001841 potential frameshift: common BLAST hit: gi|89256080|ref|YP_513442.1| proton-dependent oligopeptide transport (POT) family protein 1232394001842 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1232394001843 RNA methyltransferase, RsmE family; Region: TIGR00046 1232394001844 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1232394001845 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1232394001846 mce related protein; Region: MCE; pfam02470 1232394001847 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1232394001848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394001849 Walker A/P-loop; other site 1232394001850 ATP binding site [chemical binding]; other site 1232394001851 Q-loop/lid; other site 1232394001852 ABC transporter signature motif; other site 1232394001853 Walker B; other site 1232394001854 D-loop; other site 1232394001855 H-loop/switch region; other site 1232394001856 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1232394001857 Permease; Region: Permease; pfam02405 1232394001858 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1232394001859 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1232394001860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232394001861 RNA binding surface [nucleotide binding]; other site 1232394001862 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1232394001863 active site 1232394001864 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1232394001865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1232394001866 TPR motif; other site 1232394001867 binding surface 1232394001868 potential frameshift: common BLAST hit: gi|115314566|ref|YP_763289.1| FAD-binding protein 1232394001869 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1232394001870 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1232394001871 dimer interface [polypeptide binding]; other site 1232394001872 active site 1232394001873 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1232394001874 folate binding site [chemical binding]; other site 1232394001875 hypothetical protein; Provisional; Region: PRK05255 1232394001876 potential frameshift: common BLAST hit: gi|187931600|ref|YP_001891584.1| membrane protein 1232394001877 potential frameshift: common BLAST hit: gi|187931600|ref|YP_001891584.1| membrane protein 1232394001878 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1232394001879 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1232394001880 Ligand binding site; other site 1232394001881 metal-binding site 1232394001882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232394001883 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1232394001884 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1232394001885 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1232394001886 active site 1232394001887 potential frameshift: common BLAST hit: gi|118497836|ref|YP_898886.1| proton-dependent oligopeptide transporter (POT) family protein, di- 1232394001888 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1232394001889 Ligand Binding Site [chemical binding]; other site 1232394001890 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1232394001891 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1232394001892 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1232394001893 ligand binding site [chemical binding]; other site 1232394001894 NAD binding site [chemical binding]; other site 1232394001895 tetramer interface [polypeptide binding]; other site 1232394001896 catalytic site [active] 1232394001897 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1232394001898 L-serine binding site [chemical binding]; other site 1232394001899 ACT domain interface; other site 1232394001900 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1232394001901 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1232394001902 dimerization interface [polypeptide binding]; other site 1232394001903 active site 1232394001904 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1232394001905 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1232394001906 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1232394001907 homodimer interface [polypeptide binding]; other site 1232394001908 oligonucleotide binding site [chemical binding]; other site 1232394001909 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1232394001910 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1232394001911 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394001912 catalytic residue [active] 1232394001913 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1232394001914 Recombination protein O N terminal; Region: RecO_N; pfam11967 1232394001915 Recombination protein O C terminal; Region: RecO_C; pfam02565 1232394001916 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1232394001917 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232394001918 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1232394001919 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1232394001920 BolA-like protein; Region: BolA; cl00386 1232394001921 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1232394001922 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1232394001923 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232394001924 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1232394001925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232394001926 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1232394001927 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1232394001928 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1232394001929 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1232394001930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232394001931 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1232394001932 active site 1232394001933 motif I; other site 1232394001934 motif II; other site 1232394001935 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232394001936 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1232394001937 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1232394001938 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1232394001939 dimer interface [polypeptide binding]; other site 1232394001940 active site 1232394001941 metal binding site [ion binding]; metal-binding site 1232394001942 glutathione binding site [chemical binding]; other site 1232394001943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394001944 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394001945 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394001946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394001947 potential frameshift: common BLAST hit: gi|118497776|ref|YP_898826.1| M13 family metallopeptidase 1232394001948 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1232394001949 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232394001950 active site 1232394001951 dimer interface [polypeptide binding]; other site 1232394001952 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1232394001953 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1232394001954 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1232394001955 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232394001956 potential frameshift: common BLAST hit: gi|385794957|ref|YP_005831363.1| LysR family transcriptional regulator 1232394001957 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1232394001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394001959 NAD(P) binding site [chemical binding]; other site 1232394001960 active site 1232394001961 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1232394001962 active site 1232394001963 catalytic site [active] 1232394001964 substrate binding site [chemical binding]; other site 1232394001965 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1232394001966 excinuclease ABC subunit B; Provisional; Region: PRK05298 1232394001967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394001968 ATP binding site [chemical binding]; other site 1232394001969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394001970 nucleotide binding region [chemical binding]; other site 1232394001971 ATP-binding site [chemical binding]; other site 1232394001972 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1232394001973 UvrB/uvrC motif; Region: UVR; pfam02151 1232394001974 Nuclease-related domain; Region: NERD; pfam08378 1232394001975 potential frameshift: common BLAST hit: gi|385794952|ref|YP_005831358.1| glutamate racemase 1232394001976 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394001977 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394001978 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394001979 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394001980 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1232394001981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1232394001982 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1232394001983 putative dimer interface [polypeptide binding]; other site 1232394001984 putative active site [active] 1232394001985 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1232394001986 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1232394001987 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1232394001988 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1232394001989 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1232394001990 metal binding site [ion binding]; metal-binding site 1232394001991 dimer interface [polypeptide binding]; other site 1232394001992 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1232394001993 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1232394001994 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1232394001995 generic binding surface II; other site 1232394001996 generic binding surface I; other site 1232394001997 potential frameshift: common BLAST hit: gi|134302170|ref|YP_001122139.1| major facilitator superfamily transporter 1232394001998 potential frameshift: common BLAST hit: gi|118497756|ref|YP_898806.1| metabolite:H+ symporter (MHS) family protein 1232394001999 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1232394002000 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1232394002001 Ligand Binding Site [chemical binding]; other site 1232394002002 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1232394002003 SmpB-tmRNA interface; other site 1232394002004 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1232394002005 putative coenzyme Q binding site [chemical binding]; other site 1232394002006 hypothetical protein; Validated; Region: PRK01777 1232394002007 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232394002008 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 1232394002009 VacJ like lipoprotein; Region: VacJ; cl01073 1232394002010 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1232394002011 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1232394002012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394002013 S-adenosylmethionine binding site [chemical binding]; other site 1232394002014 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1232394002015 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1232394002016 G1 box; other site 1232394002017 putative GEF interaction site [polypeptide binding]; other site 1232394002018 GTP/Mg2+ binding site [chemical binding]; other site 1232394002019 Switch I region; other site 1232394002020 G2 box; other site 1232394002021 G3 box; other site 1232394002022 Switch II region; other site 1232394002023 G4 box; other site 1232394002024 G5 box; other site 1232394002025 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1232394002026 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1232394002027 potential frameshift: common BLAST hit: gi|118497745|ref|YP_898795.1| type I restriction-modification system subunit R (restriction) 1232394002028 potential frameshift: common BLAST hit: gi|118497745|ref|YP_898795.1| type I restriction-modification system subunit R (restriction) 1232394002029 potential frameshift: common BLAST hit: gi|167627748|ref|YP_001678248.1| type I restriction-modification system subunit R (restriction) 1232394002030 potential frameshift: common BLAST hit: gi|387824775|ref|YP_005824246.1| Type I restriction-modification system, restriction subunit R 1232394002031 potential frameshift: common BLAST hit: gi|118497745|ref|YP_898795.1| type I restriction-modification system subunit R (restriction) 1232394002032 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1232394002033 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1232394002034 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1232394002035 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1232394002036 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232394002037 DNA-binding site [nucleotide binding]; DNA binding site 1232394002038 RNA-binding motif; other site 1232394002039 potential frameshift: common BLAST hit: gi|110670712|ref|YP_667269.1| DNA-methyltransferase, type I restriction-modification enzyme 1232394002040 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394002041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394002042 Sel1-like repeats; Region: SEL1; smart00671 1232394002043 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1232394002044 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1232394002045 GTP/Mg2+ binding site [chemical binding]; other site 1232394002046 G4 box; other site 1232394002047 G5 box; other site 1232394002048 G1 box; other site 1232394002049 Switch I region; other site 1232394002050 G2 box; other site 1232394002051 G3 box; other site 1232394002052 Switch II region; other site 1232394002053 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1232394002054 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1232394002055 active site 1232394002056 dimer interface [polypeptide binding]; other site 1232394002057 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1232394002058 Glycoprotease family; Region: Peptidase_M22; pfam00814 1232394002059 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1232394002060 putative active site [active] 1232394002061 putative dimer interface [polypeptide binding]; other site 1232394002062 aspartate aminotransferase; Provisional; Region: PRK05764 1232394002063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1232394002064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394002065 homodimer interface [polypeptide binding]; other site 1232394002066 catalytic residue [active] 1232394002067 GTPase Era; Reviewed; Region: era; PRK00089 1232394002068 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1232394002069 G1 box; other site 1232394002070 GTP/Mg2+ binding site [chemical binding]; other site 1232394002071 Switch I region; other site 1232394002072 G2 box; other site 1232394002073 Switch II region; other site 1232394002074 G3 box; other site 1232394002075 G4 box; other site 1232394002076 G5 box; other site 1232394002077 potential frameshift: common BLAST hit: gi|118497733|ref|YP_898783.1| 4Fe-4S ferredoxin 1232394002078 potential frameshift: common BLAST hit: gi|118497733|ref|YP_898783.1| 4Fe-4S ferredoxin 1232394002079 adenylate kinase; Reviewed; Region: adk; PRK00279 1232394002080 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1232394002081 AMP-binding site [chemical binding]; other site 1232394002082 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1232394002083 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1232394002084 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1232394002085 Pilus assembly protein, PilO; Region: PilO; cl01234 1232394002086 Pilus assembly protein, PilP; Region: PilP; pfam04351 1232394002087 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1232394002088 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1232394002089 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1232394002090 shikimate kinase; Reviewed; Region: aroK; PRK00131 1232394002091 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1232394002092 ADP binding site [chemical binding]; other site 1232394002093 magnesium binding site [ion binding]; other site 1232394002094 putative shikimate binding site; other site 1232394002095 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1232394002096 active site 1232394002097 dimer interface [polypeptide binding]; other site 1232394002098 metal binding site [ion binding]; metal-binding site 1232394002099 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 1232394002100 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1232394002101 Proline dehydrogenase; Region: Pro_dh; pfam01619 1232394002102 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1232394002103 Glutamate binding site [chemical binding]; other site 1232394002104 NAD binding site [chemical binding]; other site 1232394002105 catalytic residues [active] 1232394002106 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232394002107 NAD(P) binding site [chemical binding]; other site 1232394002108 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232394002109 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232394002110 benzoate transport; Region: 2A0115; TIGR00895 1232394002111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394002112 putative substrate translocation pore; other site 1232394002113 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1232394002114 Flavoprotein; Region: Flavoprotein; pfam02441 1232394002115 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1232394002116 potential frameshift: common BLAST hit: gi|118497717|ref|YP_898767.1| aldose 1-epimerase 1232394002117 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 1232394002118 potential frameshift: common BLAST hit: gi|118497715|ref|YP_898765.1| short chain dehydrogenase 1232394002119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394002120 NAD(P) binding site [chemical binding]; other site 1232394002121 PRC-barrel domain; Region: PRC; pfam05239 1232394002122 PRC-barrel domain; Region: PRC; pfam05239 1232394002123 potential frameshift: common BLAST hit: gi|134302129|ref|YP_001122098.1| deoxyribodipyrimidine photolyase 1232394002124 potential frameshift: common BLAST hit: gi|89256362|ref|YP_513724.1| transposase 1232394002125 DNA photolyase; Region: DNA_photolyase; pfam00875 1232394002126 ferrochelatase; Reviewed; Region: hemH; PRK00035 1232394002127 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1232394002128 C-terminal domain interface [polypeptide binding]; other site 1232394002129 active site 1232394002130 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1232394002131 active site 1232394002132 N-terminal domain interface [polypeptide binding]; other site 1232394002133 Predicted membrane protein [Function unknown]; Region: COG1511 1232394002134 potential frameshift: common BLAST hit: gi|118497707|ref|YP_898757.1| ATP-binding protein 1232394002135 potential frameshift: common BLAST hit: gi|118497707|ref|YP_898757.1| ATP-binding protein 1232394002136 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1232394002137 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1232394002138 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1232394002139 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1232394002140 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1232394002141 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1232394002142 Walker A motif; other site 1232394002143 ATP binding site [chemical binding]; other site 1232394002144 Walker B motif; other site 1232394002145 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1232394002146 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1232394002147 active site 1232394002148 catalytic site [active] 1232394002149 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1232394002150 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1232394002151 putative MPT binding site; other site 1232394002152 cyanophycin synthetase; Provisional; Region: PRK14016 1232394002153 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232394002154 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394002155 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232394002156 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394002157 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232394002158 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1232394002159 homotrimer interaction site [polypeptide binding]; other site 1232394002160 zinc binding site [ion binding]; other site 1232394002161 CDP-binding sites; other site 1232394002162 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232394002163 active site residue [active] 1232394002164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1232394002165 active site residue [active] 1232394002166 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232394002167 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232394002168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232394002169 dimer interface [polypeptide binding]; other site 1232394002170 conserved gate region; other site 1232394002171 putative PBP binding loops; other site 1232394002172 ABC-ATPase subunit interface; other site 1232394002173 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1232394002174 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1232394002175 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1232394002176 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1232394002177 Walker A/P-loop; other site 1232394002178 ATP binding site [chemical binding]; other site 1232394002179 Q-loop/lid; other site 1232394002180 ABC transporter signature motif; other site 1232394002181 Walker B; other site 1232394002182 D-loop; other site 1232394002183 H-loop/switch region; other site 1232394002184 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1232394002185 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1232394002186 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 1232394002187 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 1232394002188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 1232394002189 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1232394002190 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1232394002191 potential frameshift: common BLAST hit: gi|89256204|ref|YP_513566.1| LysR transcriptional regulator family protein 1232394002192 potential frameshift: common BLAST hit: gi|385794877|ref|YP_005831283.1| isochorismatase hydrolase family protein 1232394002193 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1232394002194 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1232394002195 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1232394002196 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1232394002197 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1232394002198 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1232394002199 Protein export membrane protein; Region: SecD_SecF; pfam02355 1232394002200 Src Homology 3 domain superfamily; Region: SH3; cl17036 1232394002201 peptide ligand binding site [polypeptide binding]; other site 1232394002202 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1232394002203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232394002204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232394002205 DNA binding residues [nucleotide binding] 1232394002206 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1232394002207 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1232394002208 hinge; other site 1232394002209 active site 1232394002210 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1232394002211 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232394002212 active site 1232394002213 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1232394002214 active site 1232394002215 homodimer interface [polypeptide binding]; other site 1232394002216 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1232394002217 active site clefts [active] 1232394002218 zinc binding site [ion binding]; other site 1232394002219 dimer interface [polypeptide binding]; other site 1232394002220 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1232394002221 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1232394002222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394002223 catalytic residue [active] 1232394002224 Rubredoxin [Energy production and conversion]; Region: COG1773 1232394002225 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1232394002226 iron binding site [ion binding]; other site 1232394002227 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394002228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394002229 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394002230 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1232394002231 hypothetical protein; Validated; Region: PRK00029 1232394002232 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1232394002233 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1232394002234 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1232394002235 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1232394002236 dimer interface [polypeptide binding]; other site 1232394002237 active site 1232394002238 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1232394002239 dimer interface [polypeptide binding]; other site 1232394002240 active site 1232394002241 potential frameshift: common BLAST hit: gi|89256225|ref|YP_513587.1| major facilitator transporter 1232394002242 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 1232394002243 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1232394002244 potential frameshift: common BLAST hit: gi|156502539|ref|YP_001428604.1| transposase ISFTu2 1232394002245 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1232394002246 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1232394002247 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232394002248 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1232394002249 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1232394002250 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1232394002251 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1232394002252 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1232394002253 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1232394002254 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1232394002255 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1232394002256 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1232394002257 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1232394002258 active site 1232394002259 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1232394002260 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1232394002261 active site 1232394002262 substrate binding site [chemical binding]; other site 1232394002263 Mg2+ binding site [ion binding]; other site 1232394002264 beta-lactamase TEM; Provisional; Region: PRK15442 1232394002265 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1232394002266 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1232394002267 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1232394002268 putative active site [active] 1232394002269 catalytic triad [active] 1232394002270 putative dimer interface [polypeptide binding]; other site 1232394002271 FOG: CBS domain [General function prediction only]; Region: COG0517 1232394002272 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232394002273 Transporter associated domain; Region: CorC_HlyC; smart01091 1232394002274 metal-binding heat shock protein; Provisional; Region: PRK00016 1232394002275 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1232394002276 PhoH-like protein; Region: PhoH; pfam02562 1232394002277 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1232394002278 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1232394002279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394002280 FeS/SAM binding site; other site 1232394002281 TRAM domain; Region: TRAM; pfam01938 1232394002282 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1232394002283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232394002284 potential frameshift: common BLAST hit: gi|385794381|ref|YP_005830787.1| HAD superfamily protein 1232394002285 thymidine kinase; Provisional; Region: PRK04296 1232394002286 trigger factor; Provisional; Region: tig; PRK01490 1232394002287 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232394002288 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1232394002289 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1232394002290 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1232394002291 oligomer interface [polypeptide binding]; other site 1232394002292 active site residues [active] 1232394002293 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1232394002294 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1232394002295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394002296 Walker A motif; other site 1232394002297 ATP binding site [chemical binding]; other site 1232394002298 Walker B motif; other site 1232394002299 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1232394002300 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1232394002301 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1232394002302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394002303 Walker A motif; other site 1232394002304 ATP binding site [chemical binding]; other site 1232394002305 Walker B motif; other site 1232394002306 arginine finger; other site 1232394002307 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1232394002308 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1232394002309 IHF dimer interface [polypeptide binding]; other site 1232394002310 IHF - DNA interface [nucleotide binding]; other site 1232394002311 SurA N-terminal domain; Region: SurA_N_3; cl07813 1232394002312 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1232394002313 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1232394002314 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1232394002315 bacterial Hfq-like; Region: Hfq; cd01716 1232394002316 hexamer interface [polypeptide binding]; other site 1232394002317 Sm1 motif; other site 1232394002318 RNA binding site [nucleotide binding]; other site 1232394002319 Sm2 motif; other site 1232394002320 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1232394002321 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1232394002322 HflX GTPase family; Region: HflX; cd01878 1232394002323 G1 box; other site 1232394002324 GTP/Mg2+ binding site [chemical binding]; other site 1232394002325 Switch I region; other site 1232394002326 G2 box; other site 1232394002327 G3 box; other site 1232394002328 Switch II region; other site 1232394002329 G4 box; other site 1232394002330 G5 box; other site 1232394002331 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232394002332 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1232394002333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232394002334 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1232394002335 HflK protein; Region: hflK; TIGR01933 1232394002336 FtsH protease regulator HflC; Provisional; Region: PRK11029 1232394002337 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1232394002338 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1232394002339 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1232394002340 active site 1232394002341 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1232394002342 G1 box; other site 1232394002343 GTP/Mg2+ binding site [chemical binding]; other site 1232394002344 Switch I region; other site 1232394002345 G2 box; other site 1232394002346 G3 box; other site 1232394002347 Switch II region; other site 1232394002348 G4 box; other site 1232394002349 G5 box; other site 1232394002350 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1232394002351 homodimer interface [polypeptide binding]; other site 1232394002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394002353 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1232394002354 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1232394002355 potential frameshift: common BLAST hit: gi|187931885|ref|YP_001891870.1| dihydroxy-acid dehydratase 1232394002356 potential frameshift: common BLAST hit: gi|118497633|ref|YP_898683.1| acetolactate synthase large subunit 1232394002357 potential frameshift: common BLAST hit: gi|118497633|ref|YP_898683.1| acetolactate synthase large subunit 1232394002358 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1232394002359 putative valine binding site [chemical binding]; other site 1232394002360 dimer interface [polypeptide binding]; other site 1232394002361 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 1232394002362 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1232394002363 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1232394002364 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1232394002365 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1232394002366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394002367 ATP binding site [chemical binding]; other site 1232394002368 putative Mg++ binding site [ion binding]; other site 1232394002369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394002370 nucleotide binding region [chemical binding]; other site 1232394002371 ATP-binding site [chemical binding]; other site 1232394002372 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1232394002373 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1232394002374 YccA-like proteins; Region: YccA_like; cd10433 1232394002375 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1232394002376 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1232394002377 minor groove reading motif; other site 1232394002378 helix-hairpin-helix signature motif; other site 1232394002379 substrate binding pocket [chemical binding]; other site 1232394002380 active site 1232394002381 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1232394002382 ferredoxin; Provisional; Region: PRK08764 1232394002383 Putative Fe-S cluster; Region: FeS; cl17515 1232394002384 4Fe-4S binding domain; Region: Fer4; pfam00037 1232394002385 glutaredoxin 2; Provisional; Region: PRK10387 1232394002386 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232394002387 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1232394002388 N-terminal domain interface [polypeptide binding]; other site 1232394002389 POT family; Region: PTR2; cl17359 1232394002390 POT family; Region: PTR2; cl17359 1232394002391 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1232394002392 Ferritin-like domain; Region: Ferritin; pfam00210 1232394002393 ferroxidase diiron center [ion binding]; other site 1232394002394 lipoyl synthase; Provisional; Region: PRK05481 1232394002395 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394002396 FeS/SAM binding site; other site 1232394002397 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1232394002398 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1232394002399 conserved cys residue [active] 1232394002400 hypothetical protein; Validated; Region: PRK00110 1232394002401 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1232394002402 active site 1232394002403 putative DNA-binding cleft [nucleotide binding]; other site 1232394002404 dimer interface [polypeptide binding]; other site 1232394002405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394002406 putative substrate translocation pore; other site 1232394002407 D-galactonate transporter; Region: 2A0114; TIGR00893 1232394002408 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1232394002409 RuvA N terminal domain; Region: RuvA_N; pfam01330 1232394002410 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1232394002411 RmuC family; Region: RmuC; pfam02646 1232394002412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1232394002413 dimerization interface [polypeptide binding]; other site 1232394002414 putative Zn2+ binding site [ion binding]; other site 1232394002415 putative DNA binding site [nucleotide binding]; other site 1232394002416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 1232394002417 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1232394002418 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232394002419 histidine decarboxylase; Provisional; Region: PRK02769 1232394002420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394002421 catalytic residue [active] 1232394002422 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1232394002423 intersubunit interface [polypeptide binding]; other site 1232394002424 active site 1232394002425 Zn2+ binding site [ion binding]; other site 1232394002426 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1232394002427 active site 1232394002428 DNA binding site [nucleotide binding] 1232394002429 Isochorismatase family; Region: Isochorismatase; pfam00857 1232394002430 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1232394002431 catalytic triad [active] 1232394002432 conserved cis-peptide bond; other site 1232394002433 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1232394002434 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1232394002435 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1232394002436 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232394002437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394002438 putative substrate translocation pore; other site 1232394002439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394002440 potential frameshift: common BLAST hit: gi|385794431|ref|YP_005830837.1| major facilitator superfamily (MFS) transport protein 1232394002441 potential frameshift: common BLAST hit: gi|118497602|ref|YP_898652.1| major facilitator transporter 1232394002442 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1232394002443 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1232394002444 putative active site [active] 1232394002445 Zn binding site [ion binding]; other site 1232394002446 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1232394002447 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1232394002448 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394002449 active site 1232394002450 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1232394002451 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1232394002452 5S rRNA interface [nucleotide binding]; other site 1232394002453 CTC domain interface [polypeptide binding]; other site 1232394002454 L16 interface [polypeptide binding]; other site 1232394002455 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1232394002456 Domain of unknown function DUF21; Region: DUF21; pfam01595 1232394002457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1232394002458 Transporter associated domain; Region: CorC_HlyC; pfam03471 1232394002459 potential frameshift: common BLAST hit: gi|385794436|ref|YP_005830842.1| methlytransferase, UbiE/COQ5 family protein 1232394002460 GTP-binding protein YchF; Reviewed; Region: PRK09601 1232394002461 YchF GTPase; Region: YchF; cd01900 1232394002462 G1 box; other site 1232394002463 GTP/Mg2+ binding site [chemical binding]; other site 1232394002464 Switch I region; other site 1232394002465 G2 box; other site 1232394002466 Switch II region; other site 1232394002467 G3 box; other site 1232394002468 G4 box; other site 1232394002469 G5 box; other site 1232394002470 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1232394002471 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1232394002472 putative active site [active] 1232394002473 catalytic residue [active] 1232394002474 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1232394002475 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1232394002476 dimerization domain [polypeptide binding]; other site 1232394002477 dimer interface [polypeptide binding]; other site 1232394002478 catalytic residues [active] 1232394002479 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1232394002480 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1232394002481 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1232394002482 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1232394002483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394002484 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232394002485 Ion channel; Region: Ion_trans_2; pfam07885 1232394002486 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1232394002487 POT family; Region: PTR2; cl17359 1232394002488 potential frameshift: common BLAST hit: gi|385794446|ref|YP_005830852.1| ATP-dependent protease ATP-binding subunit 1232394002489 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1232394002490 active site 1232394002491 HslU subunit interaction site [polypeptide binding]; other site 1232394002492 potential frameshift: common BLAST hit: gi|385794449|ref|YP_005830855.1| lipoate-protein ligase A 1232394002493 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1232394002494 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1232394002495 active site 1232394002496 HIGH motif; other site 1232394002497 dimer interface [polypeptide binding]; other site 1232394002498 KMSKS motif; other site 1232394002499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232394002500 RNA binding surface [nucleotide binding]; other site 1232394002501 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394002502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394002503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394002504 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394002505 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1232394002506 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232394002507 phosphate binding site [ion binding]; other site 1232394002508 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1232394002509 FAD binding domain; Region: FAD_binding_4; pfam01565 1232394002510 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1232394002511 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1232394002512 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1232394002513 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1232394002514 dimer interface [polypeptide binding]; other site 1232394002515 active site 1232394002516 metal binding site [ion binding]; metal-binding site 1232394002517 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1232394002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394002519 S-adenosylmethionine binding site [chemical binding]; other site 1232394002520 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1232394002521 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1232394002522 FMN binding site [chemical binding]; other site 1232394002523 active site 1232394002524 catalytic residues [active] 1232394002525 substrate binding site [chemical binding]; other site 1232394002526 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1232394002527 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1232394002528 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1232394002529 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1232394002530 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1232394002531 putative active site [active] 1232394002532 AAA domain; Region: AAA_21; pfam13304 1232394002533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1232394002534 ABC transporter signature motif; other site 1232394002535 Walker B; other site 1232394002536 D-loop; other site 1232394002537 H-loop/switch region; other site 1232394002538 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1232394002539 active site 1232394002540 DNA polymerase IV; Validated; Region: PRK02406 1232394002541 DNA binding site [nucleotide binding] 1232394002542 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1232394002543 DJ-1 family protein; Region: not_thiJ; TIGR01383 1232394002544 conserved cys residue [active] 1232394002545 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232394002546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232394002547 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232394002548 bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional; Region: PRK12759 1232394002549 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1232394002550 GSH binding site [chemical binding]; other site 1232394002551 catalytic residues [active] 1232394002552 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1232394002553 dimer interface [polypeptide binding]; other site 1232394002554 putative radical transfer pathway; other site 1232394002555 diiron center [ion binding]; other site 1232394002556 tyrosyl radical; other site 1232394002557 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1232394002558 GSH binding site [chemical binding]; other site 1232394002559 catalytic residues [active] 1232394002560 potential frameshift: common BLAST hit: gi|156502406|ref|YP_001428471.1| ribonucleotide-diphosphate reductase subunit alpha 1232394002561 malate dehydrogenase; Reviewed; Region: PRK06223 1232394002562 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1232394002563 NAD(P) binding site [chemical binding]; other site 1232394002564 dimer interface [polypeptide binding]; other site 1232394002565 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1232394002566 substrate binding site [chemical binding]; other site 1232394002567 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1232394002568 diiron binding motif [ion binding]; other site 1232394002569 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232394002570 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232394002571 catalytic residue [active] 1232394002572 potential frameshift: common BLAST hit: gi|118497568|ref|YP_898618.1| ThiF family protein 1232394002573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394002574 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394002575 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394002576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394002577 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1232394002578 ATP binding site [chemical binding]; other site 1232394002579 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1232394002580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232394002581 motif II; other site 1232394002582 peroxidase; Provisional; Region: PRK15000 1232394002583 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1232394002584 dimer interface [polypeptide binding]; other site 1232394002585 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1232394002586 catalytic triad [active] 1232394002587 peroxidatic and resolving cysteines [active] 1232394002588 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1232394002589 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1232394002590 PhnA protein; Region: PhnA; pfam03831 1232394002591 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1232394002592 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1232394002593 active site 1232394002594 catalytic site [active] 1232394002595 substrate binding site [chemical binding]; other site 1232394002596 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1232394002597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1232394002598 potential frameshift: common BLAST hit: gi|118497556|ref|YP_898606.1| dehydrogenase 1232394002599 potential frameshift: common BLAST hit: gi|118497556|ref|YP_898606.1| dehydrogenase 1232394002600 potential frameshift: common BLAST hit: gi|118497556|ref|YP_898606.1| dehydrogenase 1232394002601 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1232394002602 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1232394002603 putative homodimer interface [polypeptide binding]; other site 1232394002604 putative homotetramer interface [polypeptide binding]; other site 1232394002605 putative allosteric switch controlling residues; other site 1232394002606 putative metal binding site [ion binding]; other site 1232394002607 putative homodimer-homodimer interface [polypeptide binding]; other site 1232394002608 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232394002609 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1232394002610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232394002611 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1232394002612 dimerization interface [polypeptide binding]; other site 1232394002613 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1232394002614 catalytic triad [active] 1232394002615 dimer interface [polypeptide binding]; other site 1232394002616 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232394002617 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1232394002618 putative NAD(P) binding site [chemical binding]; other site 1232394002619 homodimer interface [polypeptide binding]; other site 1232394002620 cytidylate kinase; Provisional; Region: cmk; PRK00023 1232394002621 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1232394002622 CMP-binding site; other site 1232394002623 The sites determining sugar specificity; other site 1232394002624 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1232394002625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394002626 catalytic residue [active] 1232394002627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394002628 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394002629 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394002630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394002631 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1232394002632 catalytic core [active] 1232394002633 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1232394002634 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1232394002635 potential frameshift: common BLAST hit: gi|89256362|ref|YP_513724.1| transposase 1232394002636 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1232394002637 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1232394002638 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1232394002639 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1232394002640 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1232394002641 replicative DNA helicase; Region: DnaB; TIGR00665 1232394002642 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1232394002643 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1232394002644 Walker A motif; other site 1232394002645 ATP binding site [chemical binding]; other site 1232394002646 Walker B motif; other site 1232394002647 DNA binding loops [nucleotide binding] 1232394002648 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1232394002649 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394002650 FeS/SAM binding site; other site 1232394002651 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1232394002652 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1232394002653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232394002654 RNA binding surface [nucleotide binding]; other site 1232394002655 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1232394002656 probable active site [active] 1232394002657 preprotein translocase subunit SecA; Validated; Region: secA; CHL00122 1232394002658 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1232394002659 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232394002660 Coenzyme A binding pocket [chemical binding]; other site 1232394002661 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1232394002662 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1232394002663 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1232394002664 CysD dimerization site [polypeptide binding]; other site 1232394002665 G1 box; other site 1232394002666 putative GEF interaction site [polypeptide binding]; other site 1232394002667 GTP/Mg2+ binding site [chemical binding]; other site 1232394002668 Switch I region; other site 1232394002669 G2 box; other site 1232394002670 G3 box; other site 1232394002671 Switch II region; other site 1232394002672 G4 box; other site 1232394002673 G5 box; other site 1232394002674 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1232394002675 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1232394002676 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1232394002677 ligand-binding site [chemical binding]; other site 1232394002678 PQ loop repeat; Region: PQ-loop; pfam04193 1232394002679 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1232394002680 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1232394002681 substrate binding pocket [chemical binding]; other site 1232394002682 chain length determination region; other site 1232394002683 substrate-Mg2+ binding site; other site 1232394002684 catalytic residues [active] 1232394002685 aspartate-rich region 1; other site 1232394002686 active site lid residues [active] 1232394002687 aspartate-rich region 2; other site 1232394002688 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1232394002689 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1232394002690 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1232394002691 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1232394002692 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1232394002693 Ligand Binding Site [chemical binding]; other site 1232394002694 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1232394002695 active site 1232394002696 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1232394002697 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1232394002698 catalytic residue [active] 1232394002699 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1232394002700 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1232394002701 Yqey-like protein; Region: YqeY; pfam09424 1232394002702 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1232394002703 DNA primase; Validated; Region: dnaG; PRK05667 1232394002704 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1232394002705 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1232394002706 active site 1232394002707 metal binding site [ion binding]; metal-binding site 1232394002708 interdomain interaction site; other site 1232394002709 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1232394002710 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1232394002711 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1232394002712 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1232394002713 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1232394002714 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1232394002715 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1232394002716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1232394002717 DNA binding residues [nucleotide binding] 1232394002718 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1232394002719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394002720 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1232394002721 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1232394002722 catalytic site [active] 1232394002723 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1232394002724 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1232394002725 potential frameshift: common BLAST hit: gi|387824450|ref|YP_005823921.1| Oligogalacturonide transporter 1232394002726 lipoate-protein ligase B; Provisional; Region: PRK14342 1232394002727 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1232394002728 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1232394002729 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1232394002730 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1232394002731 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1232394002732 dimer interface [polypeptide binding]; other site 1232394002733 substrate binding site [chemical binding]; other site 1232394002734 metal binding sites [ion binding]; metal-binding site 1232394002735 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1232394002736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232394002737 active site 1232394002738 motif I; other site 1232394002739 motif II; other site 1232394002740 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1232394002741 OstA-like protein; Region: OstA; cl00844 1232394002742 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1232394002743 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1232394002744 Walker A/P-loop; other site 1232394002745 ATP binding site [chemical binding]; other site 1232394002746 Q-loop/lid; other site 1232394002747 ABC transporter signature motif; other site 1232394002748 Walker B; other site 1232394002749 D-loop; other site 1232394002750 H-loop/switch region; other site 1232394002751 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1232394002752 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1232394002753 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1232394002754 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1232394002755 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232394002756 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1232394002757 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1232394002758 dimerization interface 3.5A [polypeptide binding]; other site 1232394002759 active site 1232394002760 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232394002761 GMP synthase; Reviewed; Region: guaA; PRK00074 1232394002762 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1232394002763 AMP/PPi binding site [chemical binding]; other site 1232394002764 candidate oxyanion hole; other site 1232394002765 catalytic triad [active] 1232394002766 potential glutamine specificity residues [chemical binding]; other site 1232394002767 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1232394002768 ATP Binding subdomain [chemical binding]; other site 1232394002769 Ligand Binding sites [chemical binding]; other site 1232394002770 Dimerization subdomain; other site 1232394002771 potential frameshift: common BLAST hit: gi|156502498|ref|YP_001428563.1| 1-deoxy-D-xylulose-5-phosphate synthase 1232394002772 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1232394002773 putative active site pocket [active] 1232394002774 dimerization interface [polypeptide binding]; other site 1232394002775 putative catalytic residue [active] 1232394002776 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1232394002777 active site 1232394002778 catalytic triad [active] 1232394002779 oxyanion hole [active] 1232394002780 switch loop; other site 1232394002781 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1232394002782 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1232394002783 classical (c) SDRs; Region: SDR_c; cd05233 1232394002784 NAD(P) binding site [chemical binding]; other site 1232394002785 active site 1232394002786 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1232394002787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394002788 Walker A motif; other site 1232394002789 ATP binding site [chemical binding]; other site 1232394002790 Walker B motif; other site 1232394002791 arginine finger; other site 1232394002792 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1232394002793 potential frameshift: common BLAST hit: gi|337755418|ref|YP_004647929.1| Bax protein 1232394002794 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1232394002795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232394002796 non-specific DNA binding site [nucleotide binding]; other site 1232394002797 salt bridge; other site 1232394002798 sequence-specific DNA binding site [nucleotide binding]; other site 1232394002799 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1232394002800 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1232394002801 POT family; Region: PTR2; cl17359 1232394002802 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394002803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394002804 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394002805 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1232394002806 active site 1232394002807 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1232394002808 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1232394002809 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1232394002810 potential frameshift: common BLAST hit: gi|187931907|ref|YP_001891892.1| betaine/carnitine/choline transporter (BCCT) family protein 1232394002811 TspO/MBR family; Region: TspO_MBR; pfam03073 1232394002812 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 1232394002813 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1232394002814 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1232394002815 potential frameshift: common BLAST hit: gi|118497365|ref|YP_898415.1| drug:H+ antiporter-1 (DHA1) family protein 1232394002816 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1232394002817 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1232394002818 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1232394002819 catalytic residues [active] 1232394002820 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1232394002821 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1232394002822 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1232394002823 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1232394002824 potential frameshift: common BLAST hit: gi|118497371|ref|YP_898421.1| DNA/RNA helicase superfamily I protein 1232394002825 potential frameshift: common BLAST hit: gi|134302306|ref|YP_001122275.1| UvrD/REP helicase 1232394002826 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1232394002827 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1232394002828 motif 1; other site 1232394002829 active site 1232394002830 motif 2; other site 1232394002831 motif 3; other site 1232394002832 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1232394002833 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1232394002834 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1232394002835 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1232394002836 interface (dimer of trimers) [polypeptide binding]; other site 1232394002837 Substrate-binding/catalytic site; other site 1232394002838 Zn-binding sites [ion binding]; other site 1232394002839 transaldolase-like protein; Provisional; Region: PTZ00411 1232394002840 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1232394002841 active site 1232394002842 dimer interface [polypeptide binding]; other site 1232394002843 catalytic residue [active] 1232394002844 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1232394002845 catalytic triad [active] 1232394002846 conserved cis-peptide bond; other site 1232394002847 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394002848 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394002849 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394002850 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1232394002851 Isochorismatase family; Region: Isochorismatase; pfam00857 1232394002852 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1232394002853 catalytic triad [active] 1232394002854 conserved cis-peptide bond; other site 1232394002855 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1232394002856 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1232394002857 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1232394002858 Part of AAA domain; Region: AAA_19; pfam13245 1232394002859 Family description; Region: UvrD_C_2; pfam13538 1232394002860 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1232394002861 S1 domain; Region: S1_2; pfam13509 1232394002862 S1 domain; Region: S1_2; pfam13509 1232394002863 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 1232394002864 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1232394002865 active site residue [active] 1232394002866 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1232394002867 potential frameshift: common BLAST hit: gi|385794841|ref|YP_005831247.1| membrane protein 1232394002868 HipA N-terminal domain; Region: couple_hipA; TIGR03071 1232394002869 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1232394002870 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1232394002871 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1232394002872 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1232394002873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1232394002874 non-specific DNA binding site [nucleotide binding]; other site 1232394002875 salt bridge; other site 1232394002876 sequence-specific DNA binding site [nucleotide binding]; other site 1232394002877 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394002878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394002879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1232394002880 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1232394002881 NusB family; Region: NusB; pfam01029 1232394002882 putative RNA binding site [nucleotide binding]; other site 1232394002883 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1232394002884 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1232394002885 active site 1232394002886 dimerization interface [polypeptide binding]; other site 1232394002887 Predicted membrane protein [Function unknown]; Region: COG2855 1232394002888 putative transporter; Provisional; Region: PRK03699 1232394002889 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1232394002890 YCII-related domain; Region: YCII; cl00999 1232394002891 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1232394002892 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1232394002893 dimer interface [polypeptide binding]; other site 1232394002894 active site 1232394002895 acyl carrier protein; Provisional; Region: acpP; PRK00982 1232394002896 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1232394002897 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1232394002898 NAD(P) binding site [chemical binding]; other site 1232394002899 homotetramer interface [polypeptide binding]; other site 1232394002900 homodimer interface [polypeptide binding]; other site 1232394002901 active site 1232394002902 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1232394002903 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1232394002904 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1232394002905 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1232394002906 dimer interface [polypeptide binding]; other site 1232394002907 active site 1232394002908 CoA binding pocket [chemical binding]; other site 1232394002909 putative phosphate acyltransferase; Provisional; Region: PRK05331 1232394002910 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1232394002911 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1232394002912 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1232394002913 TPP-binding site [chemical binding]; other site 1232394002914 dimer interface [polypeptide binding]; other site 1232394002915 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1232394002916 PYR/PP interface [polypeptide binding]; other site 1232394002917 dimer interface [polypeptide binding]; other site 1232394002918 TPP binding site [chemical binding]; other site 1232394002919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1232394002920 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1232394002921 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1232394002922 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1232394002923 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1232394002924 Phosphoglycerate kinase; Region: PGK; pfam00162 1232394002925 substrate binding site [chemical binding]; other site 1232394002926 hinge regions; other site 1232394002927 ADP binding site [chemical binding]; other site 1232394002928 catalytic site [active] 1232394002929 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1232394002930 pyruvate kinase; Provisional; Region: PRK05826 1232394002931 domain interfaces; other site 1232394002932 active site 1232394002933 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1232394002934 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1232394002935 intersubunit interface [polypeptide binding]; other site 1232394002936 active site 1232394002937 zinc binding site [ion binding]; other site 1232394002938 Na+ binding site [ion binding]; other site 1232394002939 Trehalase; Region: Trehalase; cl17346 1232394002940 Trehalase; Region: Trehalase; cl17346 1232394002941 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394002942 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394002943 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394002944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394002945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394002946 putative substrate translocation pore; other site 1232394002947 potential frameshift: common BLAST hit: gi|385795501|ref|YP_005831907.1| pathogenicity determinant protein D, pdpD 1232394002948 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 1232394002949 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1232394002950 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1232394002951 Intracellular growth locus C protein; Region: IglC; pfam11550 1232394002952 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1232394002953 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1232394002954 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1232394002955 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1232394002956 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1232394002957 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1232394002958 dimer interface [polypeptide binding]; other site 1232394002959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394002960 catalytic residue [active] 1232394002961 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1232394002962 active site 1232394002963 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394002964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232394002965 putative DNA binding site [nucleotide binding]; other site 1232394002966 putative Zn2+ binding site [ion binding]; other site 1232394002967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232394002968 dimerization interface [polypeptide binding]; other site 1232394002969 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1232394002970 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1232394002971 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1232394002972 G1 box; other site 1232394002973 GTP/Mg2+ binding site [chemical binding]; other site 1232394002974 Switch I region; other site 1232394002975 G2 box; other site 1232394002976 Switch II region; other site 1232394002977 G3 box; other site 1232394002978 G4 box; other site 1232394002979 G5 box; other site 1232394002980 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1232394002981 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1232394002982 30S subunit binding site; other site 1232394002983 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1232394002984 active site 1232394002985 phosphorylation site [posttranslational modification] 1232394002986 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1232394002987 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1232394002988 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1232394002989 RNA/DNA hybrid binding site [nucleotide binding]; other site 1232394002990 active site 1232394002991 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1232394002992 Na binding site [ion binding]; other site 1232394002993 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1232394002994 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232394002995 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1232394002996 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1232394002997 23S rRNA interface [nucleotide binding]; other site 1232394002998 L3 interface [polypeptide binding]; other site 1232394002999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1232394003000 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1232394003001 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1232394003002 MltA specific insert domain; Region: MltA; smart00925 1232394003003 3D domain; Region: 3D; pfam06725 1232394003004 GrpE; Region: GrpE; pfam01025 1232394003005 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1232394003006 dimer interface [polypeptide binding]; other site 1232394003007 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1232394003008 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1232394003009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232394003010 nucleotide binding site [chemical binding]; other site 1232394003011 chaperone protein DnaJ; Provisional; Region: PRK10767 1232394003012 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1232394003013 HSP70 interaction site [polypeptide binding]; other site 1232394003014 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1232394003015 substrate binding site [polypeptide binding]; other site 1232394003016 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1232394003017 Zn binding sites [ion binding]; other site 1232394003018 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1232394003019 dimer interface [polypeptide binding]; other site 1232394003020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394003021 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1232394003022 putative effector binding pocket; other site 1232394003023 dimerization interface [polypeptide binding]; other site 1232394003024 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003025 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003026 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003028 potential frameshift: common BLAST hit: gi|115314949|ref|YP_763672.1| DMT superfamily drug/metabolite transporter 1232394003029 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1232394003030 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1232394003031 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1232394003032 dimer interface [polypeptide binding]; other site 1232394003033 motif 1; other site 1232394003034 active site 1232394003035 motif 2; other site 1232394003036 motif 3; other site 1232394003037 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1232394003038 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1232394003039 putative tRNA-binding site [nucleotide binding]; other site 1232394003040 B3/4 domain; Region: B3_4; pfam03483 1232394003041 tRNA synthetase B5 domain; Region: B5; smart00874 1232394003042 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1232394003043 dimer interface [polypeptide binding]; other site 1232394003044 motif 1; other site 1232394003045 motif 3; other site 1232394003046 motif 2; other site 1232394003047 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1232394003048 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1232394003049 metal binding site 2 [ion binding]; metal-binding site 1232394003050 putative DNA binding helix; other site 1232394003051 metal binding site 1 [ion binding]; metal-binding site 1232394003052 dimer interface [polypeptide binding]; other site 1232394003053 structural Zn2+ binding site [ion binding]; other site 1232394003054 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1232394003055 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1232394003056 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1232394003057 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1232394003058 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1232394003059 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1232394003060 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 1232394003061 putative active site [active] 1232394003062 catalytic site [active] 1232394003063 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 1232394003064 putative active site [active] 1232394003065 catalytic site [active] 1232394003066 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1232394003067 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 1232394003068 putative active site [active] 1232394003069 catalytic site [active] 1232394003070 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 1232394003071 putative active site [active] 1232394003072 catalytic site [active] 1232394003073 potential frameshift: common BLAST hit: gi|134301899|ref|YP_001121868.1| major facilitator transporter 1232394003074 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394003075 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1232394003076 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1232394003077 Walker A motif; other site 1232394003078 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1232394003079 trimer interface [polypeptide binding]; other site 1232394003080 active site 1232394003081 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232394003082 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232394003083 Lipopolysaccharide-assembly; Region: LptE; cl01125 1232394003084 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1232394003085 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1232394003086 HIGH motif; other site 1232394003087 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1232394003088 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1232394003089 active site 1232394003090 KMSKS motif; other site 1232394003091 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1232394003092 tRNA binding surface [nucleotide binding]; other site 1232394003093 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232394003094 Sel1 repeat; Region: Sel1; cl02723 1232394003095 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1232394003096 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1232394003097 potential frameshift: common BLAST hit: gi|118497457|ref|YP_898507.1| mutator protein 1232394003098 hypothetical protein; Provisional; Region: PRK07505 1232394003099 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1232394003100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394003101 catalytic residue [active] 1232394003102 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1232394003103 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1232394003104 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1232394003105 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1232394003106 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1232394003107 catalytic residues [active] 1232394003108 potential frameshift: common BLAST hit: gi|387824515|ref|YP_005823986.1| NG,NG-dimethylarginine dimethylaminohydrolase 1 1232394003109 FeS assembly protein SufD; Region: sufD; TIGR01981 1232394003110 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1232394003111 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1232394003112 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1232394003113 Walker A/P-loop; other site 1232394003114 ATP binding site [chemical binding]; other site 1232394003115 Q-loop/lid; other site 1232394003116 ABC transporter signature motif; other site 1232394003117 Walker B; other site 1232394003118 D-loop; other site 1232394003119 H-loop/switch region; other site 1232394003120 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1232394003121 putative ABC transporter; Region: ycf24; CHL00085 1232394003122 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1232394003123 Transcriptional regulator; Region: Rrf2; pfam02082 1232394003124 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1232394003125 TrkA-N domain; Region: TrkA_N; pfam02254 1232394003126 TrkA-N domain; Region: TrkA_N; pfam02254 1232394003127 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1232394003128 potential frameshift: common BLAST hit: gi|387824522|ref|YP_005823993.1| membrane protein 1232394003129 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1232394003130 rRNA binding site [nucleotide binding]; other site 1232394003131 predicted 30S ribosome binding site; other site 1232394003132 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1232394003133 signal recognition particle protein; Provisional; Region: PRK10867 1232394003134 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1232394003135 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1232394003136 P loop; other site 1232394003137 GTP binding site [chemical binding]; other site 1232394003138 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1232394003139 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1232394003140 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1232394003141 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003144 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003145 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1232394003146 conserved cys residue [active] 1232394003147 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1232394003148 active site 1232394003149 Zn binding site [ion binding]; other site 1232394003150 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1232394003151 putative active site [active] 1232394003152 putative catalytic site [active] 1232394003153 putative DNA binding site [nucleotide binding]; other site 1232394003154 putative phosphate binding site [ion binding]; other site 1232394003155 metal binding site A [ion binding]; metal-binding site 1232394003156 putative AP binding site [nucleotide binding]; other site 1232394003157 putative metal binding site B [ion binding]; other site 1232394003158 short chain dehydrogenase; Provisional; Region: PRK07577 1232394003159 classical (c) SDRs; Region: SDR_c; cd05233 1232394003160 NAD(P) binding site [chemical binding]; other site 1232394003161 active site 1232394003162 AAA domain; Region: AAA_17; pfam13207 1232394003163 AAA domain; Region: AAA_18; pfam13238 1232394003164 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1232394003165 glutathione reductase; Validated; Region: PRK06116 1232394003166 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394003167 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1232394003168 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1232394003169 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003171 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003172 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1232394003173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003174 putative substrate translocation pore; other site 1232394003175 POT family; Region: PTR2; cl17359 1232394003176 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1232394003177 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232394003178 ATP binding site [chemical binding]; other site 1232394003179 Mg++ binding site [ion binding]; other site 1232394003180 motif III; other site 1232394003181 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394003182 nucleotide binding region [chemical binding]; other site 1232394003183 ATP-binding site [chemical binding]; other site 1232394003184 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1232394003185 GTP cyclohydrolase I; Provisional; Region: PLN03044 1232394003186 active site 1232394003187 potential frameshift: common BLAST hit: gi|187931715|ref|YP_001891699.1| carbon-nitrogen hydrolase family protein 1232394003188 potential frameshift: common BLAST hit: gi|385794703|ref|YP_005831109.1| carbon-nitrogen hydrolase 1232394003189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1232394003190 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1232394003191 active site 1232394003192 catalytic tetrad [active] 1232394003193 potential frameshift: common BLAST hit: gi|118497416|ref|YP_898466.1| major facilitator transporter 1232394003194 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1232394003195 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1232394003196 glutamine binding [chemical binding]; other site 1232394003197 catalytic triad [active] 1232394003198 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1232394003199 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1232394003200 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1232394003201 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1232394003202 substrate-cofactor binding pocket; other site 1232394003203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394003204 catalytic residue [active] 1232394003205 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1232394003206 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232394003207 acyl-activating enzyme (AAE) consensus motif; other site 1232394003208 AMP binding site [chemical binding]; other site 1232394003209 active site 1232394003210 CoA binding site [chemical binding]; other site 1232394003211 Dihydroneopterin aldolase; Region: FolB; smart00905 1232394003212 active site 1232394003213 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1232394003214 catalytic center binding site [active] 1232394003215 ATP binding site [chemical binding]; other site 1232394003216 dihydropteroate synthase; Region: DHPS; TIGR01496 1232394003217 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1232394003218 substrate binding pocket [chemical binding]; other site 1232394003219 dimer interface [polypeptide binding]; other site 1232394003220 inhibitor binding site; inhibition site 1232394003221 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1232394003222 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1232394003223 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1232394003224 potential frameshift: common BLAST hit: gi|385794694|ref|YP_005831100.1| adenosine deaminase 1232394003225 potential frameshift: common BLAST hit: gi|385794694|ref|YP_005831100.1| adenosine deaminase 1232394003226 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232394003227 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1232394003228 inhibitor-cofactor binding pocket; inhibition site 1232394003229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394003230 catalytic residue [active] 1232394003231 biotin synthase; Region: bioB; TIGR00433 1232394003232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394003233 FeS/SAM binding site; other site 1232394003234 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1232394003235 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1232394003236 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1232394003237 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394003238 catalytic residue [active] 1232394003239 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1232394003240 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1232394003241 AAA domain; Region: AAA_26; pfam13500 1232394003242 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1232394003243 dimerization interface [polypeptide binding]; other site 1232394003244 putative DNA binding site [nucleotide binding]; other site 1232394003245 putative Zn2+ binding site [ion binding]; other site 1232394003246 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1232394003247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232394003248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1232394003249 nucleotide binding site [chemical binding]; other site 1232394003250 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1232394003251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003252 putative substrate translocation pore; other site 1232394003253 acetoacetate decarboxylase; Provisional; Region: PRK02265 1232394003254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394003255 potential frameshift: common BLAST hit: gi|387824561|ref|YP_005824032.1| D-beta-hydroxybutyrate dehydrogenase 1232394003256 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1232394003257 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1232394003258 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1232394003259 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1232394003260 inhibitor-cofactor binding pocket; inhibition site 1232394003261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394003262 catalytic residue [active] 1232394003263 glutathione synthetase; Provisional; Region: PRK05246 1232394003264 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1232394003265 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1232394003266 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1232394003267 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1232394003268 putative active site [active] 1232394003269 substrate binding site [chemical binding]; other site 1232394003270 putative cosubstrate binding site; other site 1232394003271 catalytic site [active] 1232394003272 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1232394003273 substrate binding site [chemical binding]; other site 1232394003274 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1232394003275 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1232394003276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232394003277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394003278 S-adenosylmethionine binding site [chemical binding]; other site 1232394003279 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1232394003280 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1232394003281 active site 1232394003282 nucleic acid binding site [nucleotide binding]; other site 1232394003283 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003286 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003287 HI0933-like protein; Region: HI0933_like; pfam03486 1232394003288 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1232394003289 short chain dehydrogenase; Provisional; Region: PRK05993 1232394003290 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1232394003291 NADP binding site [chemical binding]; other site 1232394003292 active site 1232394003293 steroid binding site; other site 1232394003294 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1232394003295 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1232394003296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003297 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003298 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003300 SnoaL-like domain; Region: SnoaL_2; pfam12680 1232394003301 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1232394003302 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003304 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003305 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1232394003306 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1232394003307 FAD binding pocket [chemical binding]; other site 1232394003308 FAD binding motif [chemical binding]; other site 1232394003309 phosphate binding motif [ion binding]; other site 1232394003310 beta-alpha-beta structure motif; other site 1232394003311 NAD binding pocket [chemical binding]; other site 1232394003312 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1232394003313 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1232394003314 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1232394003315 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1232394003316 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1232394003317 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1232394003318 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1232394003319 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1232394003320 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1232394003321 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1232394003322 active site 1232394003323 multimer interface [polypeptide binding]; other site 1232394003324 CTP synthetase; Validated; Region: pyrG; PRK05380 1232394003325 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1232394003326 Catalytic site [active] 1232394003327 active site 1232394003328 UTP binding site [chemical binding]; other site 1232394003329 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1232394003330 active site 1232394003331 putative oxyanion hole; other site 1232394003332 catalytic triad [active] 1232394003333 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 1232394003334 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 1232394003335 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 1232394003336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003337 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003338 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003340 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1232394003341 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003342 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003343 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1232394003344 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1232394003345 potential frameshift: common BLAST hit: gi|387824702|ref|YP_005824173.1| CRISPR-associated protein Cas1 1232394003346 potential frameshift: common BLAST hit: gi|134302318|ref|YP_001122287.1| CRISPR-associated large protein 1232394003347 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1232394003348 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1232394003349 ligand binding site [chemical binding]; other site 1232394003350 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1232394003351 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1232394003352 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1232394003353 active site 1232394003354 (T/H)XGH motif; other site 1232394003355 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 1232394003356 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1232394003357 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1232394003358 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1232394003359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1232394003360 catalytic residue [active] 1232394003361 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1232394003362 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1232394003363 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1232394003364 Protein of unknown function DUF45; Region: DUF45; pfam01863 1232394003365 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1232394003366 Prephenate dehydratase; Region: PDT; pfam00800 1232394003367 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1232394003368 putative L-Phe binding site [chemical binding]; other site 1232394003369 potential frameshift: common BLAST hit: gi|118497342|ref|YP_898392.1| amino acid-polyamine-organocation (APC) superfamily protein 1232394003370 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1232394003371 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1232394003372 active site 1232394003373 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232394003374 dimer interface [polypeptide binding]; other site 1232394003375 substrate binding site [chemical binding]; other site 1232394003376 catalytic residues [active] 1232394003377 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1232394003378 POT family; Region: PTR2; cl17359 1232394003379 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 1232394003380 putative C-terminal domain interface [polypeptide binding]; other site 1232394003381 putative GSH binding site [chemical binding]; other site 1232394003382 putative dimer interface [polypeptide binding]; other site 1232394003383 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1232394003384 dimer interface [polypeptide binding]; other site 1232394003385 substrate binding pocket (H-site) [chemical binding]; other site 1232394003386 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1232394003387 putative N-terminal domain interface [polypeptide binding]; other site 1232394003388 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1232394003389 potential frameshift: common BLAST hit: gi|385794330|ref|YP_005830736.1| integral membrane protein 1232394003390 potential frameshift: common BLAST hit: gi|379725553|ref|YP_005317739.1| phosphoserine phosphatase (PSP) (O-phosphoserine phosphohydrolase) 1232394003391 potential frameshift: common BLAST hit: gi|187931927|ref|YP_001891912.1| proton-dependent oligopeptide transporter (POT) family protein, di- 1232394003392 potential frameshift: common BLAST hit: gi|118497336|ref|YP_898386.1| proton-dependent oligopeptide transporter (POT) family protein, di- 1232394003393 potential frameshift: common BLAST hit: gi|187931927|ref|YP_001891912.1| proton-dependent oligopeptide transporter (POT) family protein, di- 1232394003394 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003395 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003396 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003397 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003400 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003401 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1232394003402 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232394003403 potential frameshift: common BLAST hit: gi|385794525|ref|YP_005830931.1| tatD family hydrolase 1232394003404 recombination protein F; Reviewed; Region: recF; PRK00064 1232394003405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394003406 Walker A/P-loop; other site 1232394003407 ATP binding site [chemical binding]; other site 1232394003408 Q-loop/lid; other site 1232394003409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394003410 ABC transporter signature motif; other site 1232394003411 Walker B; other site 1232394003412 D-loop; other site 1232394003413 H-loop/switch region; other site 1232394003414 EamA-like transporter family; Region: EamA; pfam00892 1232394003415 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1232394003416 EamA-like transporter family; Region: EamA; pfam00892 1232394003417 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1232394003418 active site 1232394003419 CoA binding site [chemical binding]; other site 1232394003420 AMP binding site [chemical binding]; other site 1232394003421 potential frameshift: common BLAST hit: gi|385794518|ref|YP_005830924.1| UTP-glucose-1-phosphate uridylyltransferase 1232394003422 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1232394003423 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1232394003424 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1232394003425 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1232394003426 DNA-binding site [nucleotide binding]; DNA binding site 1232394003427 RNA-binding motif; other site 1232394003428 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1232394003429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394003430 FeS/SAM binding site; other site 1232394003431 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1232394003432 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1232394003433 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1232394003434 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1232394003435 non-specific DNA interactions [nucleotide binding]; other site 1232394003436 DNA binding site [nucleotide binding] 1232394003437 sequence specific DNA binding site [nucleotide binding]; other site 1232394003438 putative cAMP binding site [chemical binding]; other site 1232394003439 Bacterial transcriptional regulator; Region: IclR; pfam01614 1232394003440 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1232394003441 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1232394003442 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003445 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003446 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1232394003447 potential frameshift: common BLAST hit: gi|385794497|ref|YP_005830903.1| organic solvent tolerance protein 1232394003448 potential frameshift: common BLAST hit: gi|89256673|ref|YP_514035.1| organic solvent tolerance protein 1232394003449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232394003450 RNA binding surface [nucleotide binding]; other site 1232394003451 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1232394003452 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1232394003453 putative substrate binding site [chemical binding]; other site 1232394003454 putative ATP binding site [chemical binding]; other site 1232394003455 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1232394003456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1232394003457 potential frameshift: common BLAST hit: gi|387824272|ref|YP_005823743.1| Muconate cycloisomerase 1232394003458 potential frameshift: common BLAST hit: gi|134301694|ref|YP_001121662.1| mandelate racemase/muconate lactonizing protein 1232394003459 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1232394003460 catalytic residues [active] 1232394003461 dimer interface [polypeptide binding]; other site 1232394003462 Chorismate mutase type II; Region: CM_2; smart00830 1232394003463 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003464 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003465 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003466 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232394003467 active site 1232394003468 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1232394003469 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1232394003470 L-aspartate oxidase; Provisional; Region: PRK06175 1232394003471 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1232394003472 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1232394003473 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1232394003474 dimerization interface [polypeptide binding]; other site 1232394003475 active site 1232394003476 quinolinate synthetase; Provisional; Region: PRK09375 1232394003477 Guanylate kinase; Region: Guanylate_kin; pfam00625 1232394003478 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1232394003479 catalytic site [active] 1232394003480 G-X2-G-X-G-K; other site 1232394003481 helicase 45; Provisional; Region: PTZ00424 1232394003482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1232394003483 ATP binding site [chemical binding]; other site 1232394003484 Mg++ binding site [ion binding]; other site 1232394003485 motif III; other site 1232394003486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1232394003487 nucleotide binding region [chemical binding]; other site 1232394003488 ATP-binding site [chemical binding]; other site 1232394003489 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1232394003490 putative RNA binding site [nucleotide binding]; other site 1232394003491 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1232394003492 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1232394003493 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1232394003494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003495 putative substrate translocation pore; other site 1232394003496 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1232394003497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003498 putative substrate translocation pore; other site 1232394003499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003500 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1232394003501 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1232394003502 dimer interface [polypeptide binding]; other site 1232394003503 active site 1232394003504 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1232394003505 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1232394003506 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1232394003507 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1232394003508 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1232394003509 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1232394003510 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1232394003511 Ligand binding site; other site 1232394003512 oligomer interface; other site 1232394003513 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1232394003514 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1232394003515 active site 1232394003516 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003519 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003520 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1232394003521 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1232394003522 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1232394003523 23S rRNA binding site [nucleotide binding]; other site 1232394003524 L21 binding site [polypeptide binding]; other site 1232394003525 L13 binding site [polypeptide binding]; other site 1232394003526 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1232394003527 translation initiation factor IF-3; Region: infC; TIGR00168 1232394003528 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1232394003529 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1232394003530 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1232394003531 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1232394003532 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1232394003533 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1232394003534 active site 1232394003535 dimer interface [polypeptide binding]; other site 1232394003536 motif 1; other site 1232394003537 motif 2; other site 1232394003538 motif 3; other site 1232394003539 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1232394003540 anticodon binding site; other site 1232394003541 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1232394003542 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1232394003543 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1232394003544 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1232394003545 lipoyl attachment site [posttranslational modification]; other site 1232394003546 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1232394003547 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1232394003548 homodimer interface [polypeptide binding]; other site 1232394003549 active site 1232394003550 hypothetical protein; Validated; Region: PRK00153 1232394003551 recombination protein RecR; Provisional; Region: PRK13844 1232394003552 RecR protein; Region: RecR; pfam02132 1232394003553 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1232394003554 putative active site [active] 1232394003555 putative metal-binding site [ion binding]; other site 1232394003556 tetramer interface [polypeptide binding]; other site 1232394003557 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1232394003558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232394003559 Zn2+ binding site [ion binding]; other site 1232394003560 Mg2+ binding site [ion binding]; other site 1232394003561 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1232394003562 synthetase active site [active] 1232394003563 NTP binding site [chemical binding]; other site 1232394003564 metal binding site [ion binding]; metal-binding site 1232394003565 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1232394003566 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1232394003567 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 1232394003568 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1232394003569 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1232394003570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394003571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003572 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394003573 putative substrate translocation pore; other site 1232394003574 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1232394003575 catalytic nucleophile [active] 1232394003576 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1232394003577 proposed catalytic triad [active] 1232394003578 active site nucleophile [active] 1232394003579 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1232394003580 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1232394003581 substrate binding site [chemical binding]; other site 1232394003582 ATP binding site [chemical binding]; other site 1232394003583 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1232394003584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232394003585 motif II; other site 1232394003586 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1232394003587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232394003588 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232394003589 active site 1232394003590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1232394003591 active site 1232394003592 LicD family; Region: LicD; pfam04991 1232394003593 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1232394003594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394003595 S-adenosylmethionine binding site [chemical binding]; other site 1232394003596 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1232394003597 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1232394003598 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1232394003599 active site 1232394003600 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1232394003601 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232394003602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394003603 Walker A/P-loop; other site 1232394003604 ATP binding site [chemical binding]; other site 1232394003605 Q-loop/lid; other site 1232394003606 ABC transporter signature motif; other site 1232394003607 Walker B; other site 1232394003608 D-loop; other site 1232394003609 H-loop/switch region; other site 1232394003610 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1232394003611 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1232394003612 putative ADP-binding pocket [chemical binding]; other site 1232394003613 UDP-glucose 4-epimerase; Region: PLN02240 1232394003614 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1232394003615 NAD binding site [chemical binding]; other site 1232394003616 homodimer interface [polypeptide binding]; other site 1232394003617 active site 1232394003618 substrate binding site [chemical binding]; other site 1232394003619 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1232394003620 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1232394003621 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1232394003622 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1232394003623 substrate binding site [chemical binding]; other site 1232394003624 hexamer interface [polypeptide binding]; other site 1232394003625 metal binding site [ion binding]; metal-binding site 1232394003626 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1232394003627 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1232394003628 putative active site [active] 1232394003629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1232394003630 DoxX; Region: DoxX; pfam07681 1232394003631 hypothetical protein; Provisional; Region: PRK05409 1232394003632 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232394003633 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1232394003634 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003635 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003636 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003637 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1232394003638 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1232394003639 NAD binding site [chemical binding]; other site 1232394003640 homotetramer interface [polypeptide binding]; other site 1232394003641 homodimer interface [polypeptide binding]; other site 1232394003642 substrate binding site [chemical binding]; other site 1232394003643 active site 1232394003644 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1232394003645 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003647 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003648 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003651 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003652 potential frameshift: common BLAST hit: gi|156502901|ref|YP_001428966.1| excinuclease ABC subunit C 1232394003653 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1232394003654 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1232394003655 catalytic site [active] 1232394003656 putative active site [active] 1232394003657 putative substrate binding site [chemical binding]; other site 1232394003658 HRDC domain; Region: HRDC; pfam00570 1232394003659 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1232394003660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003661 putative substrate translocation pore; other site 1232394003662 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1232394003663 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1232394003664 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1232394003665 potential frameshift: common BLAST hit: gi|118497270|ref|YP_898320.1| glycerate kinase 1232394003666 potential frameshift: common BLAST hit: gi|118497269|ref|YP_898319.1| 3-methyladenine DNA glycosylase 1232394003667 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1232394003668 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394003669 ATP binding site [chemical binding]; other site 1232394003670 putative Mg++ binding site [ion binding]; other site 1232394003671 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1232394003672 SEC-C motif; Region: SEC-C; pfam02810 1232394003673 LPP20 lipoprotein; Region: LPP20; cl15824 1232394003674 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1232394003675 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003678 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003679 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003681 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003682 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1232394003683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394003684 Walker A motif; other site 1232394003685 ATP binding site [chemical binding]; other site 1232394003686 Walker B motif; other site 1232394003687 arginine finger; other site 1232394003688 Peptidase family M41; Region: Peptidase_M41; pfam01434 1232394003689 putative transporter; Provisional; Region: PRK10504 1232394003690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003691 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003692 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003693 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003694 potential frameshift: common BLAST hit: gi|118497263|ref|YP_898313.1| drug:H+ antiporter-1 (DHA2) family protein 1232394003695 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1232394003696 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232394003697 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1232394003698 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1232394003699 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1232394003700 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1232394003701 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1232394003702 Type II transport protein GspH; Region: GspH; pfam12019 1232394003703 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1232394003704 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1232394003705 active site 1232394003706 dimer interface [polypeptide binding]; other site 1232394003707 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1232394003708 dimer interface [polypeptide binding]; other site 1232394003709 active site 1232394003710 Thiamine pyrophosphokinase; Region: TPK; cd07995 1232394003711 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1232394003712 active site 1232394003713 dimerization interface [polypeptide binding]; other site 1232394003714 thiamine binding site [chemical binding]; other site 1232394003715 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1232394003716 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1232394003717 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1232394003718 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1232394003719 active site 1232394003720 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1232394003721 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1232394003722 interface (dimer of trimers) [polypeptide binding]; other site 1232394003723 Substrate-binding/catalytic site; other site 1232394003724 Zn-binding sites [ion binding]; other site 1232394003725 Predicted permeases [General function prediction only]; Region: COG0795 1232394003726 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1232394003727 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1232394003728 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1232394003729 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1232394003730 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1232394003731 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1232394003732 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1232394003733 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1232394003734 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1232394003735 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1232394003736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232394003737 Predicted membrane protein [Function unknown]; Region: COG2860 1232394003738 UPF0126 domain; Region: UPF0126; pfam03458 1232394003739 UPF0126 domain; Region: UPF0126; pfam03458 1232394003740 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1232394003741 active site 1232394003742 dinuclear metal binding site [ion binding]; other site 1232394003743 dimerization interface [polypeptide binding]; other site 1232394003744 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1232394003745 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1232394003746 active site 1232394003747 catalytic motif [active] 1232394003748 Zn binding site [ion binding]; other site 1232394003749 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1232394003750 FAD binding domain; Region: FAD_binding_4; pfam01565 1232394003751 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1232394003752 phosphoglyceromutase; Provisional; Region: PRK05434 1232394003753 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1232394003754 seryl-tRNA synthetase; Provisional; Region: PRK05431 1232394003755 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1232394003756 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1232394003757 dimer interface [polypeptide binding]; other site 1232394003758 active site 1232394003759 motif 1; other site 1232394003760 motif 2; other site 1232394003761 motif 3; other site 1232394003762 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232394003763 ROK family; Region: ROK; pfam00480 1232394003764 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1232394003765 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1232394003766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394003767 Walker A/P-loop; other site 1232394003768 ATP binding site [chemical binding]; other site 1232394003769 Q-loop/lid; other site 1232394003770 ABC transporter signature motif; other site 1232394003771 Walker B; other site 1232394003772 D-loop; other site 1232394003773 H-loop/switch region; other site 1232394003774 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1232394003775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232394003776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394003777 Walker A/P-loop; other site 1232394003778 ATP binding site [chemical binding]; other site 1232394003779 Q-loop/lid; other site 1232394003780 ABC transporter signature motif; other site 1232394003781 Walker B; other site 1232394003782 D-loop; other site 1232394003783 H-loop/switch region; other site 1232394003784 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1232394003785 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1232394003786 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1232394003787 homotrimer interaction site [polypeptide binding]; other site 1232394003788 putative active site [active] 1232394003789 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1232394003790 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1232394003791 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1232394003792 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1232394003793 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1232394003794 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003795 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003797 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394003798 putative substrate translocation pore; other site 1232394003799 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1232394003800 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1232394003801 Zn2+ binding site [ion binding]; other site 1232394003802 Mg2+ binding site [ion binding]; other site 1232394003803 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1232394003804 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1232394003805 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1232394003806 heme binding site [chemical binding]; other site 1232394003807 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1232394003808 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003809 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003811 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003812 classical (c) SDRs; Region: SDR_c; cd05233 1232394003813 active site 1232394003814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394003815 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1232394003816 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1232394003817 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1232394003818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003819 putative substrate translocation pore; other site 1232394003820 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1232394003821 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1232394003822 active site 1232394003823 catalytic site [active] 1232394003824 metal binding site [ion binding]; metal-binding site 1232394003825 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1232394003826 HlyD family secretion protein; Region: HlyD_3; pfam13437 1232394003827 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1232394003828 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232394003829 Walker A/P-loop; other site 1232394003830 ATP binding site [chemical binding]; other site 1232394003831 Q-loop/lid; other site 1232394003832 ABC transporter signature motif; other site 1232394003833 Walker B; other site 1232394003834 D-loop; other site 1232394003835 H-loop/switch region; other site 1232394003836 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1232394003837 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1232394003838 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1232394003839 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394003840 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394003841 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394003842 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1232394003843 putative substrate binding pocket [chemical binding]; other site 1232394003844 trimer interface [polypeptide binding]; other site 1232394003845 potential frameshift: common BLAST hit: gi|118497226|ref|YP_898276.1| formyltetrahydrofolate deformylase 1232394003846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394003847 active site 1232394003848 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1232394003849 Glyco_18 domain; Region: Glyco_18; smart00636 1232394003850 active site 1232394003851 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1232394003852 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1232394003853 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1232394003854 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1232394003855 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1232394003856 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1232394003857 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1232394003858 substrate-cofactor binding pocket; other site 1232394003859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1232394003860 catalytic residue [active] 1232394003861 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1232394003862 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1232394003863 NAD(P) binding site [chemical binding]; other site 1232394003864 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1232394003865 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1232394003866 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1232394003867 substrate binding site; other site 1232394003868 dimer interface; other site 1232394003869 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1232394003870 Septum formation initiator; Region: DivIC; cl17659 1232394003871 enolase; Provisional; Region: eno; PRK00077 1232394003872 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1232394003873 dimer interface [polypeptide binding]; other site 1232394003874 metal binding site [ion binding]; metal-binding site 1232394003875 substrate binding pocket [chemical binding]; other site 1232394003876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394003877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003878 putative substrate translocation pore; other site 1232394003879 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1232394003880 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370 1232394003881 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1232394003882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1232394003883 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1232394003884 TRAM domain; Region: TRAM; pfam01938 1232394003885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394003886 S-adenosylmethionine binding site [chemical binding]; other site 1232394003887 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1232394003888 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1232394003889 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1232394003890 ATP-binding site [chemical binding]; other site 1232394003891 Sugar specificity; other site 1232394003892 Pyrimidine base specificity; other site 1232394003893 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1232394003894 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1232394003895 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1232394003896 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1232394003897 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1232394003898 oligomer interface [polypeptide binding]; other site 1232394003899 RNA binding site [nucleotide binding]; other site 1232394003900 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1232394003901 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1232394003902 RNase E interface [polypeptide binding]; other site 1232394003903 trimer interface [polypeptide binding]; other site 1232394003904 active site 1232394003905 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1232394003906 putative nucleic acid binding region [nucleotide binding]; other site 1232394003907 G-X-X-G motif; other site 1232394003908 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1232394003909 RNA binding site [nucleotide binding]; other site 1232394003910 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1232394003911 16S/18S rRNA binding site [nucleotide binding]; other site 1232394003912 S13e-L30e interaction site [polypeptide binding]; other site 1232394003913 25S rRNA binding site [nucleotide binding]; other site 1232394003914 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1232394003915 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1232394003916 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1232394003917 Cell division protein FtsL; Region: FtsL; cl11433 1232394003918 MraW methylase family; Region: Methyltransf_5; cl17771 1232394003919 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1232394003920 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1232394003921 AMP-binding enzyme; Region: AMP-binding; pfam00501 1232394003922 acyl-activating enzyme (AAE) consensus motif; other site 1232394003923 putative AMP binding site [chemical binding]; other site 1232394003924 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1232394003925 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1232394003926 DNA binding site [nucleotide binding] 1232394003927 catalytic residue [active] 1232394003928 H2TH interface [polypeptide binding]; other site 1232394003929 putative catalytic residues [active] 1232394003930 turnover-facilitating residue; other site 1232394003931 intercalation triad [nucleotide binding]; other site 1232394003932 8OG recognition residue [nucleotide binding]; other site 1232394003933 putative reading head residues; other site 1232394003934 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1232394003935 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1232394003936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394003937 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394003938 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394003939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394003940 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1232394003941 predicted active site [active] 1232394003942 catalytic triad [active] 1232394003943 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1232394003944 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1232394003945 active site 1232394003946 multimer interface [polypeptide binding]; other site 1232394003947 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1232394003948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232394003949 ATP binding site [chemical binding]; other site 1232394003950 Mg2+ binding site [ion binding]; other site 1232394003951 G-X-G motif; other site 1232394003952 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1232394003953 anchoring element; other site 1232394003954 dimer interface [polypeptide binding]; other site 1232394003955 ATP binding site [chemical binding]; other site 1232394003956 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1232394003957 active site 1232394003958 putative metal-binding site [ion binding]; other site 1232394003959 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1232394003960 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1232394003961 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1232394003962 FMN binding site [chemical binding]; other site 1232394003963 active site 1232394003964 catalytic residues [active] 1232394003965 substrate binding site [chemical binding]; other site 1232394003966 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232394003967 TIGR03546 family protein; Region: TIGR03546 1232394003968 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1232394003969 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1232394003970 CoA-ligase; Region: Ligase_CoA; pfam00549 1232394003971 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1232394003972 CoA binding domain; Region: CoA_binding; smart00881 1232394003973 CoA-ligase; Region: Ligase_CoA; pfam00549 1232394003974 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1232394003975 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1232394003976 potential frameshift: common BLAST hit: gi|115315229|ref|YP_763952.1| D-alanine--D-alanine ligase 1232394003977 potential frameshift: common BLAST hit: gi|118497188|ref|YP_898238.1| proton-dependent oligopeptide transporter (POT) family protein, di- 1232394003978 potential frameshift: common BLAST hit: gi|187932034|ref|YP_001892019.1| proton-dependent oligopeptide transporter (POT) family protein, di- 1232394003979 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 1232394003980 active site 1232394003981 dimer interface [polypeptide binding]; other site 1232394003982 catalytic nucleophile [active] 1232394003983 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1232394003984 MFS transport protein AraJ; Provisional; Region: PRK10091 1232394003985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394003986 putative substrate translocation pore; other site 1232394003987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394003988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232394003989 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1232394003990 putative effector binding pocket; other site 1232394003991 dimerization interface [polypeptide binding]; other site 1232394003992 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1232394003993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1232394003994 motif II; other site 1232394003995 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1232394003996 PLD-like domain; Region: PLDc_2; pfam13091 1232394003997 putative active site [active] 1232394003998 catalytic site [active] 1232394003999 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1232394004000 putative active site [active] 1232394004001 catalytic site [active] 1232394004002 thioredoxin reductase; Provisional; Region: PRK10262 1232394004003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1232394004004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1232394004005 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004007 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004011 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1232394004012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232394004013 ATP binding site [chemical binding]; other site 1232394004014 Mg2+ binding site [ion binding]; other site 1232394004015 G-X-G motif; other site 1232394004016 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1232394004017 ATP binding site [chemical binding]; other site 1232394004018 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1232394004019 Predicted GTPases [General function prediction only]; Region: COG1162 1232394004020 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1232394004021 RNA binding site [nucleotide binding]; other site 1232394004022 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1232394004023 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1232394004024 GTP/Mg2+ binding site [chemical binding]; other site 1232394004025 G4 box; other site 1232394004026 G5 box; other site 1232394004027 G1 box; other site 1232394004028 Switch I region; other site 1232394004029 G2 box; other site 1232394004030 G3 box; other site 1232394004031 Switch II region; other site 1232394004032 Protein of unknown function (DUF3281); Region: DUF3281; pfam11685 1232394004033 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1232394004034 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1232394004035 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1232394004036 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1232394004037 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1232394004038 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1232394004039 DHH family; Region: DHH; pfam01368 1232394004040 DHHA1 domain; Region: DHHA1; pfam02272 1232394004041 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1232394004042 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1232394004043 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1232394004044 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1232394004045 motif 1; other site 1232394004046 dimer interface [polypeptide binding]; other site 1232394004047 active site 1232394004048 motif 2; other site 1232394004049 motif 3; other site 1232394004050 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1232394004051 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232394004052 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004053 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004054 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004055 Helix-turn-helix domain; Region: HTH_25; pfam13413 1232394004056 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1232394004057 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1232394004058 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1232394004059 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1232394004060 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1232394004061 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1232394004062 carboxyltransferase (CT) interaction site; other site 1232394004063 biotinylation site [posttranslational modification]; other site 1232394004064 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1232394004065 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1232394004066 trimer interface [polypeptide binding]; other site 1232394004067 active site 1232394004068 dimer interface [polypeptide binding]; other site 1232394004069 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1232394004070 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1232394004071 active site 1232394004072 metal binding site [ion binding]; metal-binding site 1232394004073 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1232394004074 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1232394004075 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1232394004076 SurA N-terminal domain; Region: SurA_N; pfam09312 1232394004077 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1232394004078 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1232394004079 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1232394004080 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1232394004081 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1232394004082 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1232394004083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232394004084 active site 1232394004085 HIGH motif; other site 1232394004086 nucleotide binding site [chemical binding]; other site 1232394004087 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1232394004088 KMSK motif region; other site 1232394004089 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1232394004090 tRNA binding surface [nucleotide binding]; other site 1232394004091 anticodon binding site; other site 1232394004092 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1232394004093 active site 1232394004094 homodimer interface [polypeptide binding]; other site 1232394004095 homotetramer interface [polypeptide binding]; other site 1232394004096 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1232394004097 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1232394004098 dimer interface [polypeptide binding]; other site 1232394004099 active site 1232394004100 Schiff base residues; other site 1232394004101 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1232394004102 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1232394004103 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1232394004104 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1232394004105 putative inner membrane peptidase; Provisional; Region: PRK11778 1232394004106 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1232394004107 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1232394004108 tandem repeat interface [polypeptide binding]; other site 1232394004109 oligomer interface [polypeptide binding]; other site 1232394004110 active site residues [active] 1232394004111 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1232394004112 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1232394004113 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1232394004114 dimer interface [polypeptide binding]; other site 1232394004115 N-terminal domain interface [polypeptide binding]; other site 1232394004116 DsrC like protein; Region: DsrC; pfam04358 1232394004117 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1232394004118 oxidative damage protection protein; Provisional; Region: PRK05408 1232394004119 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1232394004120 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1232394004121 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004124 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004125 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1232394004126 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1232394004127 Ligand binding site; other site 1232394004128 Putative Catalytic site; other site 1232394004129 DXD motif; other site 1232394004130 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 1232394004131 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1232394004132 putative active site [active] 1232394004133 YdjC motif; other site 1232394004134 Mg binding site [ion binding]; other site 1232394004135 putative homodimer interface [polypeptide binding]; other site 1232394004136 cell division protein FtsW; Region: ftsW; TIGR02614 1232394004137 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1232394004138 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1232394004139 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1232394004140 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1232394004141 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1232394004142 Mg++ binding site [ion binding]; other site 1232394004143 putative catalytic motif [active] 1232394004144 putative substrate binding site [chemical binding]; other site 1232394004145 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344 1232394004146 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1232394004147 active site 1232394004148 metal-binding site [ion binding] 1232394004149 nucleotide-binding site [chemical binding]; other site 1232394004150 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1232394004151 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1232394004152 active site 1232394004153 HIGH motif; other site 1232394004154 nucleotide binding site [chemical binding]; other site 1232394004155 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1232394004156 KMSKS motif; other site 1232394004157 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1232394004158 POT family; Region: PTR2; cl17359 1232394004159 ABC transporter ATPase component; Reviewed; Region: PRK11147 1232394004160 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1232394004161 Walker A/P-loop; other site 1232394004162 ATP binding site [chemical binding]; other site 1232394004163 Q-loop/lid; other site 1232394004164 ABC transporter signature motif; other site 1232394004165 Walker B; other site 1232394004166 D-loop; other site 1232394004167 H-loop/switch region; other site 1232394004168 ABC transporter; Region: ABC_tran_2; pfam12848 1232394004169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232394004170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004172 putative substrate translocation pore; other site 1232394004173 Predicted membrane protein [Function unknown]; Region: COG4129 1232394004174 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1232394004175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004176 putative substrate translocation pore; other site 1232394004177 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1232394004178 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1232394004179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004180 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004181 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004183 potential frameshift: common BLAST hit: gi|385795316|ref|YP_005831722.1| membrane protein 1232394004184 potential frameshift: common BLAST hit: gi|385795316|ref|YP_005831722.1| membrane protein 1232394004185 potential frameshift: common BLAST hit: gi|385795316|ref|YP_005831722.1| membrane protein 1232394004186 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004189 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394004191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232394004192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1232394004193 dimerization interface [polypeptide binding]; other site 1232394004194 potential frameshift: common BLAST hit: gi|115315283|ref|YP_764006.1| chitinase 1232394004195 potential frameshift: common BLAST hit: gi|134301414|ref|YP_001121382.1| glycosyl hydrolase family protein 1232394004196 VacJ like lipoprotein; Region: VacJ; cl01073 1232394004197 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1232394004198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394004199 S-adenosylmethionine binding site [chemical binding]; other site 1232394004200 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1232394004201 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1232394004202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004203 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004204 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004206 glycerol kinase; Provisional; Region: glpK; PRK00047 1232394004207 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1232394004208 N- and C-terminal domain interface [polypeptide binding]; other site 1232394004209 active site 1232394004210 MgATP binding site [chemical binding]; other site 1232394004211 catalytic site [active] 1232394004212 metal binding site [ion binding]; metal-binding site 1232394004213 glycerol binding site [chemical binding]; other site 1232394004214 homotetramer interface [polypeptide binding]; other site 1232394004215 homodimer interface [polypeptide binding]; other site 1232394004216 FBP binding site [chemical binding]; other site 1232394004217 protein IIAGlc interface [polypeptide binding]; other site 1232394004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004219 putative substrate translocation pore; other site 1232394004220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004222 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004223 putative substrate translocation pore; other site 1232394004224 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1232394004225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1232394004226 Walker A/P-loop; other site 1232394004227 ATP binding site [chemical binding]; other site 1232394004228 Q-loop/lid; other site 1232394004229 ABC transporter signature motif; other site 1232394004230 Walker B; other site 1232394004231 D-loop; other site 1232394004232 H-loop/switch region; other site 1232394004233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1232394004234 potential frameshift: common BLAST hit: gi|118498155|ref|YP_899205.1| peptide/opine/nickel uptake transporter (PepT) family protein 1232394004235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1232394004236 dimer interface [polypeptide binding]; other site 1232394004237 conserved gate region; other site 1232394004238 ABC-ATPase subunit interface; other site 1232394004239 potential frameshift: common BLAST hit: gi|118498157|ref|YP_899207.1| oligopeptide ABC transporter periplasmic protein 1232394004240 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004241 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004242 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004243 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1232394004244 Part of AAA domain; Region: AAA_19; pfam13245 1232394004245 Family description; Region: UvrD_C_2; pfam13538 1232394004246 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1232394004247 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1232394004248 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1232394004249 GTP binding site [chemical binding]; other site 1232394004250 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1232394004251 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1232394004252 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1232394004253 G1 box; other site 1232394004254 putative GEF interaction site [polypeptide binding]; other site 1232394004255 GTP/Mg2+ binding site [chemical binding]; other site 1232394004256 Switch I region; other site 1232394004257 G2 box; other site 1232394004258 G3 box; other site 1232394004259 Switch II region; other site 1232394004260 G4 box; other site 1232394004261 G5 box; other site 1232394004262 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1232394004263 thymidylate kinase; Validated; Region: tmk; PRK00698 1232394004264 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1232394004265 TMP-binding site; other site 1232394004266 ATP-binding site [chemical binding]; other site 1232394004267 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1232394004268 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1232394004269 Nucleoside recognition; Region: Gate; pfam07670 1232394004270 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1232394004271 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1232394004272 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1232394004273 Nucleoside recognition; Region: Gate; pfam07670 1232394004274 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1232394004275 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1232394004276 intersubunit interface [polypeptide binding]; other site 1232394004277 active site 1232394004278 catalytic residue [active] 1232394004279 phosphopentomutase; Provisional; Region: PRK05362 1232394004280 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1232394004281 pantothenate kinase; Reviewed; Region: PRK13324 1232394004282 DNA polymerase I; Provisional; Region: PRK05755 1232394004283 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1232394004284 active site 1232394004285 metal binding site 1 [ion binding]; metal-binding site 1232394004286 putative 5' ssDNA interaction site; other site 1232394004287 metal binding site 3; metal-binding site 1232394004288 metal binding site 2 [ion binding]; metal-binding site 1232394004289 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1232394004290 putative DNA binding site [nucleotide binding]; other site 1232394004291 putative metal binding site [ion binding]; other site 1232394004292 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1232394004293 active site 1232394004294 catalytic site [active] 1232394004295 substrate binding site [chemical binding]; other site 1232394004296 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1232394004297 active site 1232394004298 DNA binding site [nucleotide binding] 1232394004299 catalytic site [active] 1232394004300 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1232394004301 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1232394004302 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1232394004303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1232394004304 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1232394004305 Walker A/P-loop; other site 1232394004306 ATP binding site [chemical binding]; other site 1232394004307 Q-loop/lid; other site 1232394004308 ABC transporter signature motif; other site 1232394004309 Walker B; other site 1232394004310 D-loop; other site 1232394004311 H-loop/switch region; other site 1232394004312 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13296 1232394004313 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1232394004314 active site 1232394004315 NTP binding site [chemical binding]; other site 1232394004316 metal binding triad [ion binding]; metal-binding site 1232394004317 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1232394004318 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1232394004319 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1232394004320 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1232394004321 HlyD family secretion protein; Region: HlyD_3; pfam13437 1232394004322 multidrug efflux protein; Reviewed; Region: PRK09579 1232394004323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004324 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1232394004325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004326 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1232394004327 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1232394004328 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1232394004329 dimer interface [polypeptide binding]; other site 1232394004330 catalytic triad [active] 1232394004331 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1232394004332 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004333 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004334 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004336 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004337 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004339 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1232394004340 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1232394004341 active site 1232394004342 HIGH motif; other site 1232394004343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1232394004344 KMSKS motif; other site 1232394004345 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1232394004346 tRNA binding surface [nucleotide binding]; other site 1232394004347 anticodon binding site; other site 1232394004348 HemK family putative methylases; Region: hemK_fam; TIGR00536 1232394004349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394004350 S-adenosylmethionine binding site [chemical binding]; other site 1232394004351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004353 putative substrate translocation pore; other site 1232394004354 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1232394004355 Coenzyme A binding pocket [chemical binding]; other site 1232394004356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004357 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004358 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004360 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1232394004361 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1232394004362 potential frameshift: common BLAST hit: gi|385795348|ref|YP_005831754.1| membrane protein 1232394004363 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1232394004364 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1232394004365 potential frameshift: common BLAST hit: gi|118496911|ref|YP_897961.1| HlyC/CorC family transporter-associated protein 1232394004366 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1232394004367 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1232394004368 DXD motif; other site 1232394004369 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1232394004370 Na binding site [ion binding]; other site 1232394004371 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1232394004372 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1232394004373 putative active site [active] 1232394004374 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1232394004375 lysine transporter; Provisional; Region: PRK10836 1232394004376 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1232394004377 active site 1232394004378 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1232394004379 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1232394004380 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1232394004381 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1232394004382 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1232394004383 Cation transport protein; Region: TrkH; cl17365 1232394004384 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1232394004385 ProQ/FINO family; Region: ProQ; smart00945 1232394004386 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1232394004387 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1232394004388 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1232394004389 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1232394004390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1232394004391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004392 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004393 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004395 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1232394004396 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1232394004397 ring oligomerisation interface [polypeptide binding]; other site 1232394004398 ATP/Mg binding site [chemical binding]; other site 1232394004399 stacking interactions; other site 1232394004400 hinge regions; other site 1232394004401 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1232394004402 oligomerisation interface [polypeptide binding]; other site 1232394004403 mobile loop; other site 1232394004404 roof hairpin; other site 1232394004405 Predicted membrane protein [Function unknown]; Region: COG4125 1232394004406 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1232394004407 hypothetical protein; Validated; Region: PRK02101 1232394004408 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004410 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1232394004411 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1232394004412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1232394004413 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1232394004414 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1232394004415 RF-1 domain; Region: RF-1; pfam00472 1232394004416 glutamyl-tRNA reductase; Provisional; Region: PRK13940 1232394004417 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1232394004418 tRNA; other site 1232394004419 putative tRNA binding site [nucleotide binding]; other site 1232394004420 putative NADP binding site [chemical binding]; other site 1232394004421 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1232394004422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1232394004423 TPR motif; other site 1232394004424 binding surface 1232394004425 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1232394004426 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1232394004427 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1232394004428 Trp docking motif [polypeptide binding]; other site 1232394004429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004430 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1232394004431 putative substrate translocation pore; other site 1232394004432 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1232394004433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232394004434 Mg2+ binding site [ion binding]; other site 1232394004435 G-X-G motif; other site 1232394004436 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1232394004437 anchoring element; other site 1232394004438 dimer interface [polypeptide binding]; other site 1232394004439 ATP binding site [chemical binding]; other site 1232394004440 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1232394004441 active site 1232394004442 metal binding site [ion binding]; metal-binding site 1232394004443 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1232394004444 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1232394004445 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1232394004446 amidase catalytic site [active] 1232394004447 Zn binding residues [ion binding]; other site 1232394004448 substrate binding site [chemical binding]; other site 1232394004449 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1232394004450 active site 1232394004451 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1232394004452 putative active site [active] 1232394004453 Ap4A binding site [chemical binding]; other site 1232394004454 nudix motif; other site 1232394004455 putative metal binding site [ion binding]; other site 1232394004456 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 1232394004457 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1232394004458 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1232394004459 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1232394004460 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1232394004461 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1232394004462 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1232394004463 active site 1232394004464 DNA binding site [nucleotide binding] 1232394004465 Int/Topo IB signature motif; other site 1232394004466 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1232394004467 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1232394004468 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK14591 1232394004469 RimM N-terminal domain; Region: RimM; pfam01782 1232394004470 PRC-barrel domain; Region: PRC; pfam05239 1232394004471 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1232394004472 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1232394004473 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1232394004474 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1232394004475 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1232394004476 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1232394004477 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1232394004478 Di-iron ligands [ion binding]; other site 1232394004479 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1232394004480 UGMP family protein; Validated; Region: PRK09604 1232394004481 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1232394004482 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1232394004483 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1232394004484 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1232394004485 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1232394004486 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1232394004487 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1232394004488 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1232394004489 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1232394004490 cleft; other site 1232394004491 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1232394004492 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 1232394004493 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1232394004494 DNA binding site [nucleotide binding] 1232394004495 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1232394004496 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1232394004497 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1232394004498 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1232394004499 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1232394004500 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1232394004501 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1232394004502 RPB3 interaction site [polypeptide binding]; other site 1232394004503 RPB1 interaction site [polypeptide binding]; other site 1232394004504 RPB11 interaction site [polypeptide binding]; other site 1232394004505 RPB10 interaction site [polypeptide binding]; other site 1232394004506 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1232394004507 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1232394004508 core dimer interface [polypeptide binding]; other site 1232394004509 peripheral dimer interface [polypeptide binding]; other site 1232394004510 L10 interface [polypeptide binding]; other site 1232394004511 L11 interface [polypeptide binding]; other site 1232394004512 putative EF-Tu interaction site [polypeptide binding]; other site 1232394004513 putative EF-G interaction site [polypeptide binding]; other site 1232394004514 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1232394004515 23S rRNA interface [nucleotide binding]; other site 1232394004516 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1232394004517 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1232394004518 mRNA/rRNA interface [nucleotide binding]; other site 1232394004519 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1232394004520 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1232394004521 23S rRNA interface [nucleotide binding]; other site 1232394004522 L7/L12 interface [polypeptide binding]; other site 1232394004523 putative thiostrepton binding site; other site 1232394004524 L25 interface [polypeptide binding]; other site 1232394004525 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1232394004526 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1232394004527 putative homodimer interface [polypeptide binding]; other site 1232394004528 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1232394004529 heterodimer interface [polypeptide binding]; other site 1232394004530 homodimer interface [polypeptide binding]; other site 1232394004531 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1232394004532 elongation factor Tu; Reviewed; Region: PRK00049 1232394004533 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1232394004534 G1 box; other site 1232394004535 GEF interaction site [polypeptide binding]; other site 1232394004536 GTP/Mg2+ binding site [chemical binding]; other site 1232394004537 Switch I region; other site 1232394004538 G2 box; other site 1232394004539 G3 box; other site 1232394004540 Switch II region; other site 1232394004541 G4 box; other site 1232394004542 G5 box; other site 1232394004543 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1232394004544 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1232394004545 Antibiotic Binding Site [chemical binding]; other site 1232394004546 potential protein location (hypothetical protein F92_09705 [Francisella tularensis subsp. holarctica F92]) that overlaps RNA (tRNA-G) 1232394004547 AAA domain; Region: AAA_30; pfam13604 1232394004548 Family description; Region: UvrD_C_2; pfam13538 1232394004549 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1232394004550 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1232394004551 amphipathic channel; other site 1232394004552 Asn-Pro-Ala signature motifs; other site 1232394004553 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1232394004554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004555 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004556 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1232394004559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232394004560 dimer interface [polypeptide binding]; other site 1232394004561 phosphorylation site [posttranslational modification] 1232394004562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232394004563 ATP binding site [chemical binding]; other site 1232394004564 Mg2+ binding site [ion binding]; other site 1232394004565 G-X-G motif; other site 1232394004566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1232394004567 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1232394004568 NAD(P) binding site [chemical binding]; other site 1232394004569 active site 1232394004570 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1232394004571 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1232394004572 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1232394004573 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 1232394004574 potential frameshift: common BLAST hit: gi|337754616|ref|YP_004647127.1| amine oxidase 1232394004575 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1232394004576 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1232394004577 ATP binding site [chemical binding]; other site 1232394004578 Walker B motif; other site 1232394004579 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1232394004580 aconitate hydratase; Validated; Region: PRK09277 1232394004581 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1232394004582 substrate binding site [chemical binding]; other site 1232394004583 ligand binding site [chemical binding]; other site 1232394004584 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1232394004585 substrate binding site [chemical binding]; other site 1232394004586 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1232394004587 Predicted membrane protein [Function unknown]; Region: COG2246 1232394004588 GtrA-like protein; Region: GtrA; pfam04138 1232394004589 HemN family oxidoreductase; Provisional; Region: PRK05660 1232394004590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1232394004591 FeS/SAM binding site; other site 1232394004592 HemN C-terminal domain; Region: HemN_C; pfam06969 1232394004593 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1232394004594 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1232394004595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1232394004596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1232394004597 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1232394004598 triosephosphate isomerase; Provisional; Region: PRK14567 1232394004599 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1232394004600 substrate binding site [chemical binding]; other site 1232394004601 dimer interface [polypeptide binding]; other site 1232394004602 catalytic triad [active] 1232394004603 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14320 1232394004604 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1232394004605 active site 1232394004606 substrate binding site [chemical binding]; other site 1232394004607 metal binding site [ion binding]; metal-binding site 1232394004608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394004609 active site 1232394004610 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232394004611 E3 interaction surface; other site 1232394004612 lipoyl attachment site [posttranslational modification]; other site 1232394004613 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1232394004614 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232394004615 E3 interaction surface; other site 1232394004616 lipoyl attachment site [posttranslational modification]; other site 1232394004617 e3 binding domain; Region: E3_binding; pfam02817 1232394004618 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1232394004619 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1232394004620 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1232394004621 TPP-binding site [chemical binding]; other site 1232394004622 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1232394004623 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1232394004624 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1232394004625 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1232394004626 L-aspartate oxidase; Provisional; Region: PRK06175 1232394004627 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1232394004628 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1232394004629 SdhC subunit interface [polypeptide binding]; other site 1232394004630 proximal heme binding site [chemical binding]; other site 1232394004631 Iron-sulfur protein interface; other site 1232394004632 proximal quinone binding site [chemical binding]; other site 1232394004633 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1232394004634 Iron-sulfur protein interface; other site 1232394004635 proximal quinone binding site [chemical binding]; other site 1232394004636 SdhD (CybS) interface [polypeptide binding]; other site 1232394004637 proximal heme binding site [chemical binding]; other site 1232394004638 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1232394004639 dimer interface [polypeptide binding]; other site 1232394004640 Citrate synthase; Region: Citrate_synt; pfam00285 1232394004641 active site 1232394004642 citrylCoA binding site [chemical binding]; other site 1232394004643 NADH binding [chemical binding]; other site 1232394004644 cationic pore residues; other site 1232394004645 oxalacetate/citrate binding site [chemical binding]; other site 1232394004646 coenzyme A binding site [chemical binding]; other site 1232394004647 catalytic triad [active] 1232394004648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004649 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1232394004650 putative substrate translocation pore; other site 1232394004651 superoxide dismutase; Provisional; Region: PRK10543 1232394004652 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1232394004653 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1232394004654 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1232394004655 putative GSH binding site [chemical binding]; other site 1232394004656 catalytic residues [active] 1232394004657 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1232394004658 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1232394004659 putative active site [active] 1232394004660 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13452 1232394004661 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1232394004662 gamma subunit interface [polypeptide binding]; other site 1232394004663 epsilon subunit interface [polypeptide binding]; other site 1232394004664 LBP interface [polypeptide binding]; other site 1232394004665 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1232394004666 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1232394004667 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1232394004668 alpha subunit interaction interface [polypeptide binding]; other site 1232394004669 Walker A motif; other site 1232394004670 ATP binding site [chemical binding]; other site 1232394004671 Walker B motif; other site 1232394004672 inhibitor binding site; inhibition site 1232394004673 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1232394004674 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1232394004675 core domain interface [polypeptide binding]; other site 1232394004676 delta subunit interface [polypeptide binding]; other site 1232394004677 epsilon subunit interface [polypeptide binding]; other site 1232394004678 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1232394004679 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1232394004680 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1232394004681 beta subunit interaction interface [polypeptide binding]; other site 1232394004682 Walker A motif; other site 1232394004683 ATP binding site [chemical binding]; other site 1232394004684 Walker B motif; other site 1232394004685 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1232394004686 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1232394004687 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1232394004688 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1232394004689 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1232394004690 F0F1 ATP synthase subunit C; Provisional; Region: PRK13464 1232394004691 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1232394004692 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1232394004693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004695 putative substrate translocation pore; other site 1232394004696 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1232394004697 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1232394004698 RNA binding surface [nucleotide binding]; other site 1232394004699 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1232394004700 active site 1232394004701 Predicted ATPase [General function prediction only]; Region: COG1485 1232394004702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004703 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1232394004704 putative substrate translocation pore; other site 1232394004705 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1232394004706 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1232394004707 dimer interface [polypeptide binding]; other site 1232394004708 motif 1; other site 1232394004709 active site 1232394004710 motif 2; other site 1232394004711 motif 3; other site 1232394004712 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1232394004713 anticodon binding site; other site 1232394004714 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1232394004715 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232394004716 translation initiation factor IF-2; Region: IF-2; TIGR00487 1232394004717 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1232394004718 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1232394004719 G1 box; other site 1232394004720 putative GEF interaction site [polypeptide binding]; other site 1232394004721 GTP/Mg2+ binding site [chemical binding]; other site 1232394004722 Switch I region; other site 1232394004723 G2 box; other site 1232394004724 G3 box; other site 1232394004725 Switch II region; other site 1232394004726 G4 box; other site 1232394004727 G5 box; other site 1232394004728 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1232394004729 Translation-initiation factor 2; Region: IF-2; pfam11987 1232394004730 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1232394004731 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1232394004732 NusA N-terminal domain; Region: NusA_N; pfam08529 1232394004733 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1232394004734 RNA binding site [nucleotide binding]; other site 1232394004735 homodimer interface [polypeptide binding]; other site 1232394004736 NusA-like KH domain; Region: KH_5; pfam13184 1232394004737 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1232394004738 G-X-X-G motif; other site 1232394004739 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1232394004740 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1232394004741 hypothetical protein; Provisional; Region: PRK14641 1232394004742 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1232394004743 putative oligomer interface [polypeptide binding]; other site 1232394004744 putative RNA binding site [nucleotide binding]; other site 1232394004745 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1232394004746 substrate binding site [chemical binding]; other site 1232394004747 active site 1232394004748 potential frameshift: common BLAST hit: gi|118498226|ref|YP_899276.1| magnesium chelatase 1232394004749 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004750 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004752 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004753 putative ATP-dependent protease; Provisional; Region: PRK09862 1232394004754 Membrane fusogenic activity; Region: BMFP; pfam04380 1232394004755 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1232394004756 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232394004757 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1232394004758 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232394004759 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1232394004760 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1232394004761 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1232394004762 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1232394004763 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1232394004764 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1232394004765 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1232394004766 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1232394004767 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1232394004768 NADH dehydrogenase subunit G; Validated; Region: PRK09129 1232394004769 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1232394004770 catalytic loop [active] 1232394004771 iron binding site [ion binding]; other site 1232394004772 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1232394004773 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 1232394004774 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1232394004775 SLBB domain; Region: SLBB; pfam10531 1232394004776 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1232394004777 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1232394004778 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1232394004779 putative dimer interface [polypeptide binding]; other site 1232394004780 [2Fe-2S] cluster binding site [ion binding]; other site 1232394004781 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1232394004782 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1232394004783 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1232394004784 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1232394004785 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1232394004786 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1232394004787 ferric uptake regulator; Provisional; Region: fur; PRK09462 1232394004788 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1232394004789 metal binding site 2 [ion binding]; metal-binding site 1232394004790 putative DNA binding helix; other site 1232394004791 metal binding site 1 [ion binding]; metal-binding site 1232394004792 dimer interface [polypeptide binding]; other site 1232394004793 structural Zn2+ binding site [ion binding]; other site 1232394004794 IucA / IucC family; Region: IucA_IucC; pfam04183 1232394004795 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1232394004796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1232394004797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004798 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1232394004799 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 1232394004800 dimer interface [polypeptide binding]; other site 1232394004801 active site 1232394004802 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1232394004803 catalytic residues [active] 1232394004804 substrate binding site [chemical binding]; other site 1232394004805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004806 putative substrate translocation pore; other site 1232394004807 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 1232394004808 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1232394004809 active site 1232394004810 oxyanion hole [active] 1232394004811 catalytic triad [active] 1232394004812 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1232394004813 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1232394004814 GatB domain; Region: GatB_Yqey; smart00845 1232394004815 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1232394004816 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1232394004817 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1232394004818 HlyD family secretion protein; Region: HlyD_3; pfam13437 1232394004819 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1232394004820 potential frameshift: common BLAST hit: gi|134301234|ref|YP_001121202.1| antibiotic ABC transporter 1232394004821 potential frameshift: common BLAST hit: gi|118498254|ref|YP_899304.1| ATP-binding cassette (ABC) superfamily protein 1232394004822 adenylosuccinate lyase; Provisional; Region: PRK07492 1232394004823 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1232394004824 tetramer interface [polypeptide binding]; other site 1232394004825 active site 1232394004826 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004827 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004828 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004829 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1232394004830 active site 1232394004831 catalytic residues [active] 1232394004832 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 1232394004833 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 1232394004834 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1232394004835 potential frameshift: common BLAST hit: gi|392396710|ref|YP_006433311.1| DNA-methyltransferase Dcm 1232394004836 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1232394004837 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1232394004838 dimerization interface [polypeptide binding]; other site 1232394004839 ATP binding site [chemical binding]; other site 1232394004840 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1232394004841 dimerization interface [polypeptide binding]; other site 1232394004842 ATP binding site [chemical binding]; other site 1232394004843 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1232394004844 putative active site [active] 1232394004845 catalytic triad [active] 1232394004846 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1232394004847 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1232394004848 active site 1232394004849 tetramer interface [polypeptide binding]; other site 1232394004850 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394004851 active site 1232394004852 potential frameshift: common BLAST hit: gi|134301225|ref|YP_001121193.1| glutamate decarboxylase 1232394004853 potential frameshift: common BLAST hit: gi|89257118|ref|YP_514480.1| glutamate decarboxylase 1232394004854 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1232394004855 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1232394004856 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1232394004857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1232394004858 putative protease; Provisional; Region: PRK15452 1232394004859 Peptidase family U32; Region: Peptidase_U32; pfam01136 1232394004860 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1232394004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394004862 putative substrate translocation pore; other site 1232394004863 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1232394004864 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1232394004865 potential frameshift: common BLAST hit: gi|118498269|ref|YP_899319.1| ATP-binding cassette (ABC) superfamily protein 1232394004866 potential frameshift: common BLAST hit: gi|118498269|ref|YP_899319.1| ATP-binding cassette (ABC) superfamily protein 1232394004867 Amino acid permease; Region: AA_permease_2; pfam13520 1232394004868 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1232394004869 GTP1/OBG; Region: GTP1_OBG; pfam01018 1232394004870 Obg GTPase; Region: Obg; cd01898 1232394004871 G1 box; other site 1232394004872 GTP/Mg2+ binding site [chemical binding]; other site 1232394004873 Switch I region; other site 1232394004874 G2 box; other site 1232394004875 G3 box; other site 1232394004876 Switch II region; other site 1232394004877 G4 box; other site 1232394004878 G5 box; other site 1232394004879 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1232394004880 aromatic amino acid transport protein; Region: araaP; TIGR00837 1232394004881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1232394004882 DNA binding site [nucleotide binding] 1232394004883 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1232394004884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1232394004885 dimer interface [polypeptide binding]; other site 1232394004886 phosphorylation site [posttranslational modification] 1232394004887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1232394004888 ATP binding site [chemical binding]; other site 1232394004889 Mg2+ binding site [ion binding]; other site 1232394004890 G-X-G motif; other site 1232394004891 potential frameshift: common BLAST hit: gi|118498276|ref|YP_899326.1| two component regulator, sensor histidine kinase kdpD 1232394004892 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1232394004893 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1232394004894 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1232394004895 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1232394004896 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1232394004897 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1232394004898 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004899 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004900 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1232394004901 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004904 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004905 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1232394004906 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1232394004907 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1232394004908 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1232394004909 substrate binding site [chemical binding]; other site 1232394004910 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1232394004911 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1232394004912 substrate binding site [chemical binding]; other site 1232394004913 ligand binding site [chemical binding]; other site 1232394004914 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1232394004915 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004917 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004918 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004919 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1232394004920 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1232394004921 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1232394004922 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1232394004923 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1232394004924 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1232394004925 glutamine synthetase; Region: PLN02284 1232394004926 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1232394004927 Eps15 homology domain; Region: EH; smart00027 1232394004928 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1232394004929 Glutaminase; Region: Glutaminase; cl00907 1232394004930 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1232394004931 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1232394004932 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1232394004933 hypothetical protein; Provisional; Region: PRK05208 1232394004934 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1232394004935 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1232394004936 dimer interface [polypeptide binding]; other site 1232394004937 putative anticodon binding site; other site 1232394004938 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1232394004939 motif 1; other site 1232394004940 active site 1232394004941 motif 2; other site 1232394004942 motif 3; other site 1232394004943 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1232394004944 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1232394004945 RF-1 domain; Region: RF-1; pfam00472 1232394004946 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14957 1232394004947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1232394004948 Walker A motif; other site 1232394004949 ATP binding site [chemical binding]; other site 1232394004950 Walker B motif; other site 1232394004951 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1232394004952 arginine finger; other site 1232394004953 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1232394004954 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1232394004955 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1232394004956 cell division protein FtsZ; Validated; Region: PRK09330 1232394004957 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1232394004958 nucleotide binding site [chemical binding]; other site 1232394004959 SulA interaction site; other site 1232394004960 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1232394004961 Cell division protein FtsA; Region: FtsA; smart00842 1232394004962 Cell division protein FtsA; Region: FtsA; pfam14450 1232394004963 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1232394004964 Cell division protein FtsQ; Region: FtsQ; pfam03799 1232394004965 D-alanyl-alanine synthetase A; Provisional; Region: PRK14569 1232394004966 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1232394004967 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232394004968 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1232394004969 nucleoside/Zn binding site; other site 1232394004970 dimer interface [polypeptide binding]; other site 1232394004971 catalytic motif [active] 1232394004972 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1232394004973 potential frameshift: common BLAST hit: gi|89257160|ref|YP_514522.1| 30S ribosomal protein S1 1232394004974 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1232394004975 potential frameshift: common BLAST hit: gi|379725229|ref|YP_005317415.1| putative small integral membrane protein 1232394004976 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1232394004977 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1232394004978 putative acyl-acceptor binding pocket; other site 1232394004979 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1232394004980 Competence protein; Region: Competence; pfam03772 1232394004981 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1232394004982 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1232394004983 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1232394004984 potential frameshift: common BLAST hit: gi|134302716|ref|YP_001122684.1| ABC transporter permease family protein 1232394004985 potential frameshift: common BLAST hit: gi|156503396|ref|YP_001429460.1| ABC transporter ATP-binding protein 1232394004986 YGGT family; Region: YGGT; pfam02325 1232394004987 YGGT family; Region: YGGT; pfam02325 1232394004988 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 1232394004989 putative active site [active] 1232394004990 Zn binding site [ion binding]; other site 1232394004991 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394004992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394004993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394004994 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394004995 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1232394004996 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1232394004997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 1232394004998 potential frameshift: common BLAST hit: gi|118496790|ref|YP_897840.1| serine permease 1232394004999 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1232394005000 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1232394005001 purine monophosphate binding site [chemical binding]; other site 1232394005002 dimer interface [polypeptide binding]; other site 1232394005003 putative catalytic residues [active] 1232394005004 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1232394005005 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1232394005006 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1232394005007 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1232394005008 GDP-binding site [chemical binding]; other site 1232394005009 ACT binding site; other site 1232394005010 IMP binding site; other site 1232394005011 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1232394005012 active site 1232394005013 potential frameshift: common BLAST hit: gi|134302689|ref|YP_001122657.1| dienelactone hydrolase family protein 1232394005014 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1232394005015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1232394005016 dimer interface [polypeptide binding]; other site 1232394005017 putative PBP binding regions; other site 1232394005018 ABC-ATPase subunit interface; other site 1232394005019 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1232394005020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394005021 Walker A/P-loop; other site 1232394005022 ATP binding site [chemical binding]; other site 1232394005023 Q-loop/lid; other site 1232394005024 ABC transporter signature motif; other site 1232394005025 Walker B; other site 1232394005026 D-loop; other site 1232394005027 H-loop/switch region; other site 1232394005028 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1232394005029 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1232394005030 intersubunit interface [polypeptide binding]; other site 1232394005031 potential frameshift: common BLAST hit: gi|118496798|ref|YP_897848.1| major facilitator transporter 1232394005032 potential frameshift: common BLAST hit: gi|187932231|ref|YP_001892216.1| major facilitator superfamily (MFS) transport protein 1232394005033 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1232394005034 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1232394005035 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1232394005036 potential frameshift: common BLAST hit: gi|385793972|ref|YP_005830378.1| ribonuclease BN-like family protein 1232394005037 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1232394005038 primosome assembly protein PriA; Validated; Region: PRK05580 1232394005039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1232394005040 ATP binding site [chemical binding]; other site 1232394005041 putative Mg++ binding site [ion binding]; other site 1232394005042 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1232394005043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1232394005044 Helix-turn-helix domain; Region: HTH_28; pfam13518 1232394005045 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1232394005046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1232394005047 potential frameshift: common BLAST hit: gi|379726601|ref|YP_005318787.1| S-adenosylmethionine-dependent methyltransferase 1232394005048 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1232394005049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1232394005050 Walker A/P-loop; other site 1232394005051 ATP binding site [chemical binding]; other site 1232394005052 Q-loop/lid; other site 1232394005053 ABC transporter signature motif; other site 1232394005054 Walker B; other site 1232394005055 D-loop; other site 1232394005056 H-loop/switch region; other site 1232394005057 ABC transporter; Region: ABC_tran_2; pfam12848 1232394005058 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1232394005059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1232394005060 metabolite-proton symporter; Region: 2A0106; TIGR00883 1232394005061 putative substrate translocation pore; other site 1232394005062 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1232394005063 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1232394005064 LysE type translocator; Region: LysE; cl00565 1232394005065 LysE type translocator; Region: LysE; cl00565 1232394005066 potential frameshift: common BLAST hit: gi|187932306|ref|YP_001892291.1| chromosome replication initiation inhibitor protein 1232394005067 potential frameshift: common BLAST hit: gi|134302789|ref|YP_001122757.1| chromosome replication initiation inhibitor protein 1232394005068 potential frameshift: common BLAST hit: gi|385795570|ref|YP_005831976.1| membrane protein 1232394005069 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1232394005070 aminopeptidase N; Provisional; Region: pepN; PRK14015 1232394005071 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1232394005072 active site 1232394005073 Zn binding site [ion binding]; other site 1232394005074 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1232394005075 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1232394005076 putative dimer interface [polypeptide binding]; other site 1232394005077 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1232394005078 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1232394005079 active site 1232394005080 ribulose/triose binding site [chemical binding]; other site 1232394005081 phosphate binding site [ion binding]; other site 1232394005082 substrate (anthranilate) binding pocket [chemical binding]; other site 1232394005083 product (indole) binding pocket [chemical binding]; other site 1232394005084 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1232394005085 active site 1232394005086 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1232394005087 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1232394005088 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1232394005089 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1232394005090 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1232394005091 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1232394005092 potential frameshift: common BLAST hit: gi|385795584|ref|YP_005831990.1| anthranilate synthase component II 1232394005093 anthranilate synthase component I; Provisional; Region: PRK13564 1232394005094 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1232394005095 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1232394005096 Trp repressor protein; Region: Trp_repressor; cl17266 1232394005097 potential frameshift: common BLAST hit: gi|169656789|ref|YP_001429513.2| ribonuclease, Rne/Rng family protein