-- dump date 20140619_093854 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1041826000001 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826000002 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826000003 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041826000004 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1041826000005 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041826000006 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1041826000007 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1041826000008 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1041826000009 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1041826000010 active site 1041826000011 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826000012 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826000013 ligand binding site [chemical binding]; other site 1041826000014 flexible hinge region; other site 1041826000015 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1041826000016 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1041826000017 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1041826000018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041826000019 Outer membrane efflux protein; Region: OEP; pfam02321 1041826000020 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 1041826000021 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1041826000022 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1041826000023 dimer interface [polypeptide binding]; other site 1041826000024 ssDNA binding site [nucleotide binding]; other site 1041826000025 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041826000026 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1041826000027 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1041826000028 minor groove reading motif; other site 1041826000029 helix-hairpin-helix signature motif; other site 1041826000030 substrate binding pocket [chemical binding]; other site 1041826000031 active site 1041826000032 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1041826000033 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1041826000034 DNA binding and oxoG recognition site [nucleotide binding] 1041826000035 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1041826000036 IHF dimer interface [polypeptide binding]; other site 1041826000037 IHF - DNA interface [nucleotide binding]; other site 1041826000038 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1041826000039 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1041826000040 homodimer interface [polypeptide binding]; other site 1041826000041 oligonucleotide binding site [chemical binding]; other site 1041826000042 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1041826000043 NADH dehydrogenase subunit B; Provisional; Region: PRK14820 1041826000044 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1041826000045 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1041826000046 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1041826000047 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1041826000048 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1041826000049 putative dimer interface [polypeptide binding]; other site 1041826000050 [2Fe-2S] cluster binding site [ion binding]; other site 1041826000051 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1041826000052 SLBB domain; Region: SLBB; pfam10531 1041826000053 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1041826000054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1041826000055 catalytic loop [active] 1041826000056 iron binding site [ion binding]; other site 1041826000057 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1041826000058 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1041826000059 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1041826000060 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1041826000061 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1041826000062 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1041826000063 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1041826000064 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1041826000065 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1041826000066 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1041826000067 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1041826000068 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1041826000069 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1041826000070 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1041826000071 Sporulation related domain; Region: SPOR; pfam05036 1041826000072 Cytochrome c; Region: Cytochrom_C; pfam00034 1041826000073 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1041826000074 heme-binding residues [chemical binding]; other site 1041826000075 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1041826000076 molybdopterin cofactor binding site; other site 1041826000077 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1041826000078 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1041826000079 4Fe-4S binding domain; Region: Fer4; cl02805 1041826000080 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1041826000081 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1041826000082 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1041826000083 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1041826000084 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1041826000085 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1041826000086 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1041826000087 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1041826000088 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1041826000089 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826000090 Outer membrane efflux protein; Region: OEP; pfam02321 1041826000091 Outer membrane efflux protein; Region: OEP; pfam02321 1041826000092 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1041826000093 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041826000094 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826000095 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041826000096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826000097 Walker A/P-loop; other site 1041826000098 ATP binding site [chemical binding]; other site 1041826000099 Q-loop/lid; other site 1041826000100 ABC transporter signature motif; other site 1041826000101 Walker B; other site 1041826000102 D-loop; other site 1041826000103 H-loop/switch region; other site 1041826000104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041826000105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041826000106 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1041826000107 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1041826000108 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1041826000109 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1041826000110 active site 1041826000111 Zn binding site [ion binding]; other site 1041826000112 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1041826000113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041826000114 Zn2+ binding site [ion binding]; other site 1041826000115 Mg2+ binding site [ion binding]; other site 1041826000116 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1041826000117 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1041826000118 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1041826000119 trimer interface [polypeptide binding]; other site 1041826000120 active site 1041826000121 UDP-GlcNAc binding site [chemical binding]; other site 1041826000122 lipid binding site [chemical binding]; lipid-binding site 1041826000123 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 1041826000124 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1041826000125 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1041826000126 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1041826000127 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1041826000128 active site 1041826000129 elongation factor P; Validated; Region: PRK00529 1041826000130 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1041826000131 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1041826000132 RNA binding site [nucleotide binding]; other site 1041826000133 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1041826000134 RNA binding site [nucleotide binding]; other site 1041826000135 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1041826000136 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1041826000137 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1041826000138 trimer interface [polypeptide binding]; other site 1041826000139 active site 1041826000140 UDP-GlcNAc binding site [chemical binding]; other site 1041826000141 lipid binding site [chemical binding]; lipid-binding site 1041826000142 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1041826000143 CoA binding domain; Region: CoA_binding; smart00881 1041826000144 CoA-ligase; Region: Ligase_CoA; pfam00549 1041826000145 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1041826000146 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1041826000147 acyl-activating enzyme (AAE) consensus motif; other site 1041826000148 putative AMP binding site [chemical binding]; other site 1041826000149 putative active site [active] 1041826000150 putative CoA binding site [chemical binding]; other site 1041826000151 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1041826000152 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041826000153 Peptidase family M48; Region: Peptidase_M48; pfam01435 1041826000154 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1041826000155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826000156 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1041826000157 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1041826000158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826000159 Walker A motif; other site 1041826000160 ATP binding site [chemical binding]; other site 1041826000161 Walker B motif; other site 1041826000162 arginine finger; other site 1041826000163 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1041826000164 cytidylate kinase; Provisional; Region: cmk; PRK00023 1041826000165 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1041826000166 CMP-binding site; other site 1041826000167 The sites determining sugar specificity; other site 1041826000168 nucleoside transporter; Region: 2A0110; TIGR00889 1041826000169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826000170 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1041826000171 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1041826000172 RNA binding site [nucleotide binding]; other site 1041826000173 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1041826000174 RNA binding site [nucleotide binding]; other site 1041826000175 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1041826000176 RNA binding site [nucleotide binding]; other site 1041826000177 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041826000178 RNA binding site [nucleotide binding]; other site 1041826000179 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041826000180 RNA binding site [nucleotide binding]; other site 1041826000181 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1041826000182 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1041826000183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826000184 active site 1041826000185 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1041826000186 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1041826000187 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1041826000188 deoxyhypusine synthase; Region: dhys; TIGR00321 1041826000189 Deoxyhypusine synthase; Region: DS; cl00826 1041826000190 Deoxyhypusine synthase; Region: DS; cl00826 1041826000191 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1041826000192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1041826000193 dimer interface [polypeptide binding]; other site 1041826000194 active site 1041826000195 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041826000196 catalytic residues [active] 1041826000197 substrate binding site [chemical binding]; other site 1041826000198 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1041826000199 active site 1041826000200 dimer interface [polypeptide binding]; other site 1041826000201 metal binding site [ion binding]; metal-binding site 1041826000202 Proline dehydrogenase; Region: Pro_dh; cl03282 1041826000203 ribonuclease Z; Reviewed; Region: PRK00055 1041826000204 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1041826000205 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1041826000206 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1041826000207 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 1041826000208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826000209 Walker A motif; other site 1041826000210 ATP binding site [chemical binding]; other site 1041826000211 Walker B motif; other site 1041826000212 arginine finger; other site 1041826000213 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1041826000214 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 1041826000215 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1041826000216 Clp amino terminal domain; Region: Clp_N; pfam02861 1041826000217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826000218 Walker A motif; other site 1041826000219 ATP binding site [chemical binding]; other site 1041826000220 Walker B motif; other site 1041826000221 arginine finger; other site 1041826000222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826000223 Walker A motif; other site 1041826000224 ATP binding site [chemical binding]; other site 1041826000225 Walker B motif; other site 1041826000226 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1041826000227 glycerol kinase; Provisional; Region: glpK; PRK00047 1041826000228 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1041826000229 N- and C-terminal domain interface [polypeptide binding]; other site 1041826000230 active site 1041826000231 MgATP binding site [chemical binding]; other site 1041826000232 catalytic site [active] 1041826000233 metal binding site [ion binding]; metal-binding site 1041826000234 glycerol binding site [chemical binding]; other site 1041826000235 homotetramer interface [polypeptide binding]; other site 1041826000236 homodimer interface [polypeptide binding]; other site 1041826000237 FBP binding site [chemical binding]; other site 1041826000238 protein IIAGlc interface [polypeptide binding]; other site 1041826000239 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1041826000240 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1041826000241 amphipathic channel; other site 1041826000242 Asn-Pro-Ala signature motifs; other site 1041826000243 RNA polymerase sigma factor; Provisional; Region: PRK12513 1041826000244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041826000245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041826000246 DNA binding residues [nucleotide binding] 1041826000247 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1041826000248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1041826000249 minor groove reading motif; other site 1041826000250 helix-hairpin-helix signature motif; other site 1041826000251 substrate binding pocket [chemical binding]; other site 1041826000252 active site 1041826000253 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1041826000254 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1041826000255 catalytic triad [active] 1041826000256 Protein of unknown function, DUF479; Region: DUF479; cl01203 1041826000257 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1041826000258 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1041826000259 active site 1041826000260 substrate binding site [chemical binding]; other site 1041826000261 metal binding site [ion binding]; metal-binding site 1041826000262 Amino acid permease; Region: AA_permease_2; pfam13520 1041826000263 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1041826000264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041826000265 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826000266 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1041826000267 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1041826000268 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1041826000269 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1041826000270 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1041826000271 homodimer interface [polypeptide binding]; other site 1041826000272 substrate-cofactor binding pocket; other site 1041826000273 catalytic residue [active] 1041826000274 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1041826000275 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826000276 ligand binding site [chemical binding]; other site 1041826000277 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826000278 ligand binding site [chemical binding]; other site 1041826000279 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1041826000280 dimerization interface [polypeptide binding]; other site 1041826000281 ATP binding site [chemical binding]; other site 1041826000282 hypothetical protein; Validated; Region: PRK00029 1041826000283 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1041826000284 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1041826000285 Predicted membrane protein [Function unknown]; Region: COG2323 1041826000286 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1041826000287 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1041826000288 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041826000289 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1041826000290 Clp amino terminal domain; Region: Clp_N; pfam02861 1041826000291 Clp amino terminal domain; Region: Clp_N; pfam02861 1041826000292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826000293 Walker A motif; other site 1041826000294 ATP binding site [chemical binding]; other site 1041826000295 Walker B motif; other site 1041826000296 arginine finger; other site 1041826000297 UvrB/uvrC motif; Region: UVR; pfam02151 1041826000298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826000299 Walker A motif; other site 1041826000300 ATP binding site [chemical binding]; other site 1041826000301 Walker B motif; other site 1041826000302 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1041826000303 DNA gyrase subunit A; Validated; Region: PRK05560 1041826000304 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1041826000305 CAP-like domain; other site 1041826000306 active site 1041826000307 primary dimer interface [polypeptide binding]; other site 1041826000308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041826000309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041826000310 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041826000311 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041826000312 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041826000313 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1041826000314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000315 binding surface 1041826000316 TPR motif; other site 1041826000317 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1041826000318 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1041826000319 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1041826000320 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1041826000321 catalytic residue [active] 1041826000322 Bacterial SH3 domain; Region: SH3_3; pfam08239 1041826000323 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826000324 Preprotein translocase subunit; Region: YajC; pfam02699 1041826000325 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1041826000326 transcription antitermination factor NusB; Region: nusB; TIGR01951 1041826000327 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1041826000328 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1041826000329 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1041826000330 NAD binding site [chemical binding]; other site 1041826000331 Phe binding site; other site 1041826000332 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041826000333 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041826000334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826000335 Walker A/P-loop; other site 1041826000336 ATP binding site [chemical binding]; other site 1041826000337 Q-loop/lid; other site 1041826000338 ABC transporter signature motif; other site 1041826000339 Walker B; other site 1041826000340 D-loop; other site 1041826000341 H-loop/switch region; other site 1041826000342 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 1041826000343 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1041826000344 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1041826000345 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826000346 catalytic residue [active] 1041826000347 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1041826000348 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1041826000349 PYR/PP interface [polypeptide binding]; other site 1041826000350 dimer interface [polypeptide binding]; other site 1041826000351 TPP binding site [chemical binding]; other site 1041826000352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041826000353 transketolase; Reviewed; Region: PRK05899 1041826000354 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1041826000355 TPP-binding site [chemical binding]; other site 1041826000356 dimer interface [polypeptide binding]; other site 1041826000357 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1041826000358 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1041826000359 Predicted permeases [General function prediction only]; Region: COG0795 1041826000360 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1041826000361 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1041826000362 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1041826000363 replicative DNA helicase; Region: DnaB; TIGR00665 1041826000364 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1041826000365 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1041826000366 Walker A motif; other site 1041826000367 ATP binding site [chemical binding]; other site 1041826000368 Walker B motif; other site 1041826000369 DNA binding loops [nucleotide binding] 1041826000370 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1041826000371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826000372 S-adenosylmethionine binding site [chemical binding]; other site 1041826000373 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1041826000374 23S rRNA binding site [nucleotide binding]; other site 1041826000375 L21 binding site [polypeptide binding]; other site 1041826000376 L13 binding site [polypeptide binding]; other site 1041826000377 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1041826000378 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1041826000379 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1041826000380 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1041826000381 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1041826000382 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1041826000383 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1041826000384 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1041826000385 active site 1041826000386 dimer interface [polypeptide binding]; other site 1041826000387 motif 1; other site 1041826000388 motif 2; other site 1041826000389 motif 3; other site 1041826000390 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1041826000391 anticodon binding site; other site 1041826000392 potential frameshift: common BLAST hit: gi|326796984|ref|YP_004314804.1| transposase mutator type 1041826000393 hypothetical protein; Provisional; Region: PRK12378 1041826000394 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1041826000395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826000396 S-adenosylmethionine binding site [chemical binding]; other site 1041826000397 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 1041826000398 AAA domain; Region: AAA_30; pfam13604 1041826000399 Family description; Region: UvrD_C_2; pfam13538 1041826000400 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1041826000401 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1041826000402 Ligand binding site; other site 1041826000403 oligomer interface; other site 1041826000404 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1041826000405 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1041826000406 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826000407 active site 1041826000408 HIGH motif; other site 1041826000409 nucleotide binding site [chemical binding]; other site 1041826000410 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1041826000411 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1041826000412 active site 1041826000413 KMSKS motif; other site 1041826000414 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1041826000415 tRNA binding surface [nucleotide binding]; other site 1041826000416 anticodon binding site; other site 1041826000417 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1041826000418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1041826000419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1041826000420 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1041826000421 dimerization interface [polypeptide binding]; other site 1041826000422 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1041826000423 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1041826000424 dimerization interface [polypeptide binding]; other site 1041826000425 DPS ferroxidase diiron center [ion binding]; other site 1041826000426 ion pore; other site 1041826000427 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1041826000428 SelR domain; Region: SelR; pfam01641 1041826000429 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1041826000430 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1041826000431 active site 1041826000432 metal binding site [ion binding]; metal-binding site 1041826000433 homotetramer interface [polypeptide binding]; other site 1041826000434 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1041826000435 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1041826000436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826000437 catalytic residue [active] 1041826000438 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1041826000439 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1041826000440 active site 1041826000441 catalytic site [active] 1041826000442 metal binding site [ion binding]; metal-binding site 1041826000443 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1041826000444 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1041826000445 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1041826000446 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1041826000447 active sites [active] 1041826000448 tetramer interface [polypeptide binding]; other site 1041826000449 YceI-like domain; Region: YceI; pfam04264 1041826000450 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1041826000451 dimer interface [polypeptide binding]; other site 1041826000452 FMN binding site [chemical binding]; other site 1041826000453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1041826000454 MarR family; Region: MarR; pfam01047 1041826000455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1041826000456 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1041826000457 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826000458 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1041826000459 putative acyl-acceptor binding pocket; other site 1041826000460 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1041826000461 putative active site [active] 1041826000462 putative CoA binding site [chemical binding]; other site 1041826000463 nudix motif; other site 1041826000464 metal binding site [ion binding]; metal-binding site 1041826000465 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 1041826000466 adenylosuccinate lyase; Provisional; Region: PRK09285 1041826000467 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1041826000468 tetramer interface [polypeptide binding]; other site 1041826000469 active site 1041826000470 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1041826000471 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1041826000472 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1041826000473 active site 1041826000474 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1041826000475 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1041826000476 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1041826000477 active site 1041826000478 short chain dehydrogenase; Validated; Region: PRK06182 1041826000479 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1041826000480 NADP binding site [chemical binding]; other site 1041826000481 active site 1041826000482 steroid binding site; other site 1041826000483 potential frameshift: common BLAST hit: gi|150025127|ref|YP_001295953.1| translaldolase 1041826000484 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1041826000485 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1041826000486 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1041826000487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826000488 putative substrate translocation pore; other site 1041826000489 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1041826000490 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041826000491 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826000492 Outer membrane efflux protein; Region: OEP; pfam02321 1041826000493 Outer membrane efflux protein; Region: OEP; pfam02321 1041826000494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041826000495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041826000496 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1041826000497 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1041826000498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826000499 S-adenosylmethionine binding site [chemical binding]; other site 1041826000500 Endonuclease I; Region: Endonuclease_1; pfam04231 1041826000501 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826000502 Endonuclease I; Region: Endonuclease_1; pfam04231 1041826000503 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1041826000504 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1041826000505 Interdomain contacts; other site 1041826000506 Cytokine receptor motif; other site 1041826000507 Lamin Tail Domain; Region: LTD; pfam00932 1041826000508 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826000509 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1041826000510 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041826000511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041826000512 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1041826000513 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826000514 active site residue [active] 1041826000515 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1041826000516 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1041826000517 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1041826000518 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1041826000519 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1041826000520 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826000521 active site 1041826000522 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1041826000523 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1041826000524 active site 1041826000525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041826000526 substrate binding site [chemical binding]; other site 1041826000527 catalytic residues [active] 1041826000528 dimer interface [polypeptide binding]; other site 1041826000529 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1041826000530 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1041826000531 CoA-ligase; Region: Ligase_CoA; pfam00549 1041826000532 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1041826000533 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1041826000534 Sulfatase; Region: Sulfatase; pfam00884 1041826000535 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1041826000536 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1041826000537 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1041826000538 HopJ type III effector protein; Region: HopJ; pfam08888 1041826000539 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1041826000540 DHH family; Region: DHH; pfam01368 1041826000541 DHHA1 domain; Region: DHHA1; pfam02272 1041826000542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826000543 H+ Antiporter protein; Region: 2A0121; TIGR00900 1041826000544 putative substrate translocation pore; other site 1041826000545 hypothetical protein; Provisional; Region: PRK14623 1041826000546 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1041826000547 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826000548 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1041826000549 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1041826000550 dimer interface [polypeptide binding]; other site 1041826000551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826000552 catalytic residue [active] 1041826000553 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1041826000554 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1041826000555 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1041826000556 shikimate binding site; other site 1041826000557 NAD(P) binding site [chemical binding]; other site 1041826000558 TPR repeat; Region: TPR_11; pfam13414 1041826000559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000560 binding surface 1041826000561 TPR motif; other site 1041826000562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000563 binding surface 1041826000564 TPR motif; other site 1041826000565 TPR repeat; Region: TPR_11; pfam13414 1041826000566 TPR repeat; Region: TPR_11; pfam13414 1041826000567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000568 binding surface 1041826000569 TPR motif; other site 1041826000570 TPR repeat; Region: TPR_11; pfam13414 1041826000571 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1041826000572 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1041826000573 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1041826000574 substrate binding site [chemical binding]; other site 1041826000575 active site 1041826000576 catalytic residues [active] 1041826000577 heterodimer interface [polypeptide binding]; other site 1041826000578 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1041826000579 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1041826000580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826000581 catalytic residue [active] 1041826000582 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1041826000583 active site 1041826000584 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1041826000585 active site 1041826000586 ribulose/triose binding site [chemical binding]; other site 1041826000587 phosphate binding site [ion binding]; other site 1041826000588 substrate (anthranilate) binding pocket [chemical binding]; other site 1041826000589 product (indole) binding pocket [chemical binding]; other site 1041826000590 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1041826000591 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1041826000592 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1041826000593 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1041826000594 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1041826000595 glutamine binding [chemical binding]; other site 1041826000596 catalytic triad [active] 1041826000597 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1041826000598 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1041826000599 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1041826000600 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1041826000601 lipoyl synthase; Provisional; Region: PRK05481 1041826000602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826000603 FeS/SAM binding site; other site 1041826000604 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1041826000605 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1041826000606 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1041826000607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826000608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000609 binding surface 1041826000610 TPR motif; other site 1041826000611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826000612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826000613 dimer interface [polypeptide binding]; other site 1041826000614 phosphorylation site [posttranslational modification] 1041826000615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826000616 ATP binding site [chemical binding]; other site 1041826000617 Mg2+ binding site [ion binding]; other site 1041826000618 G-X-G motif; other site 1041826000619 Response regulator receiver domain; Region: Response_reg; pfam00072 1041826000620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826000621 active site 1041826000622 phosphorylation site [posttranslational modification] 1041826000623 intermolecular recognition site; other site 1041826000624 dimerization interface [polypeptide binding]; other site 1041826000625 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1041826000626 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1041826000627 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1041826000628 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1041826000629 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1041826000630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1041826000631 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1041826000632 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1041826000633 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1041826000634 Putative zinc ribbon domain; Region: DUF164; pfam02591 1041826000635 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1041826000636 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041826000637 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1041826000638 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041826000639 RNA binding surface [nucleotide binding]; other site 1041826000640 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1041826000641 probable active site [active] 1041826000642 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1041826000643 CoenzymeA binding site [chemical binding]; other site 1041826000644 subunit interaction site [polypeptide binding]; other site 1041826000645 PHB binding site; other site 1041826000646 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1041826000647 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1041826000648 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1041826000649 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1041826000650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041826000651 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1041826000652 META domain; Region: META; pfam03724 1041826000653 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1041826000654 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1041826000655 putative Zn2+ binding site [ion binding]; other site 1041826000656 putative DNA binding site [nucleotide binding]; other site 1041826000657 AsnC family; Region: AsnC_trans_reg; pfam01037 1041826000658 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1041826000659 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1041826000660 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826000661 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1041826000662 active site 1041826000663 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1041826000664 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 1041826000665 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1041826000666 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1041826000667 DHH family; Region: DHH; pfam01368 1041826000668 DHHA1 domain; Region: DHHA1; pfam02272 1041826000669 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1041826000670 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826000671 FeS/SAM binding site; other site 1041826000672 HemN C-terminal domain; Region: HemN_C; pfam06969 1041826000673 Sporulation related domain; Region: SPOR; cl10051 1041826000674 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1041826000675 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041826000676 Walker A/P-loop; other site 1041826000677 ATP binding site [chemical binding]; other site 1041826000678 Q-loop/lid; other site 1041826000679 ABC transporter signature motif; other site 1041826000680 Walker B; other site 1041826000681 D-loop; other site 1041826000682 H-loop/switch region; other site 1041826000683 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1041826000684 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1041826000685 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1041826000686 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1041826000687 active site 1041826000688 NTP binding site [chemical binding]; other site 1041826000689 metal binding triad [ion binding]; metal-binding site 1041826000690 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1041826000691 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041826000692 Zn2+ binding site [ion binding]; other site 1041826000693 Mg2+ binding site [ion binding]; other site 1041826000694 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1041826000695 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1041826000696 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1041826000697 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1041826000698 putative trimer interface [polypeptide binding]; other site 1041826000699 putative CoA binding site [chemical binding]; other site 1041826000700 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1041826000701 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1041826000702 inhibitor-cofactor binding pocket; inhibition site 1041826000703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826000704 catalytic residue [active] 1041826000705 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041826000706 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826000707 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826000708 active site 1041826000709 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826000710 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1041826000711 Probable Catalytic site; other site 1041826000712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826000713 NAD(P) binding site [chemical binding]; other site 1041826000714 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1041826000715 active site 1041826000716 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1041826000717 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 1041826000718 putative heme binding pocket [chemical binding]; other site 1041826000719 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1041826000720 Sulfatase; Region: Sulfatase; pfam00884 1041826000721 hypothetical protein; Validated; Region: PRK02101 1041826000722 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1041826000723 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1041826000724 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1041826000725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041826000726 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1041826000727 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 1041826000728 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 1041826000729 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1041826000730 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1041826000731 dimerization interface [polypeptide binding]; other site 1041826000732 active site 1041826000733 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1041826000734 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1041826000735 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1041826000736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826000737 ATP binding site [chemical binding]; other site 1041826000738 putative Mg++ binding site [ion binding]; other site 1041826000739 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1041826000740 ATP-binding site [chemical binding]; other site 1041826000741 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1041826000742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826000743 active site 1041826000744 phosphorylation site [posttranslational modification] 1041826000745 intermolecular recognition site; other site 1041826000746 dimerization interface [polypeptide binding]; other site 1041826000747 LytTr DNA-binding domain; Region: LytTR; smart00850 1041826000748 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1041826000749 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1041826000750 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1041826000751 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1041826000752 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1041826000753 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1041826000754 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1041826000755 nucleotide binding pocket [chemical binding]; other site 1041826000756 K-X-D-G motif; other site 1041826000757 catalytic site [active] 1041826000758 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1041826000759 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1041826000760 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1041826000761 DNA binding site [nucleotide binding] 1041826000762 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1041826000763 Dimer interface [polypeptide binding]; other site 1041826000764 Homeodomain-like domain; Region: HTH_23; pfam13384 1041826000765 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826000766 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1041826000767 Predicted methyltransferases [General function prediction only]; Region: COG0313 1041826000768 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1041826000769 putative SAM binding site [chemical binding]; other site 1041826000770 putative homodimer interface [polypeptide binding]; other site 1041826000771 thymidine kinase; Provisional; Region: PRK04296 1041826000772 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 1041826000773 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041826000774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826000775 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1041826000776 active site 1041826000777 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041826000778 dimer interface [polypeptide binding]; other site 1041826000779 substrate binding site [chemical binding]; other site 1041826000780 catalytic residues [active] 1041826000781 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1041826000782 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1041826000783 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1041826000784 oligomerization interface [polypeptide binding]; other site 1041826000785 active site 1041826000786 metal binding site [ion binding]; metal-binding site 1041826000787 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1041826000788 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1041826000789 active site 1041826000790 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1041826000791 NAD(P) binding site [chemical binding]; other site 1041826000792 catalytic residues [active] 1041826000793 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1041826000794 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1041826000795 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1041826000796 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826000797 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826000798 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826000799 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1041826000800 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1041826000801 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826000802 FeS/SAM binding site; other site 1041826000803 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1041826000804 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1041826000805 Peptidase C39 family; Region: Peptidase_C39; pfam03412 1041826000806 putative active site [active] 1041826000807 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041826000808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826000809 Walker A/P-loop; other site 1041826000810 ATP binding site [chemical binding]; other site 1041826000811 Q-loop/lid; other site 1041826000812 ABC transporter signature motif; other site 1041826000813 Walker B; other site 1041826000814 D-loop; other site 1041826000815 H-loop/switch region; other site 1041826000816 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1041826000817 HD domain; Region: HD_4; pfam13328 1041826000818 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1041826000819 synthetase active site [active] 1041826000820 NTP binding site [chemical binding]; other site 1041826000821 metal binding site [ion binding]; metal-binding site 1041826000822 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1041826000823 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1041826000824 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1041826000825 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 1041826000826 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1041826000827 putative ligand binding site [chemical binding]; other site 1041826000828 NAD binding site [chemical binding]; other site 1041826000829 dimerization interface [polypeptide binding]; other site 1041826000830 catalytic site [active] 1041826000831 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1041826000832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826000833 catalytic residue [active] 1041826000834 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 1041826000835 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1041826000836 4Fe-4S binding domain; Region: Fer4; pfam00037 1041826000837 Haemolytic domain; Region: Haemolytic; pfam01809 1041826000838 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1041826000839 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826000840 active site 1041826000841 HIGH motif; other site 1041826000842 nucleotide binding site [chemical binding]; other site 1041826000843 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1041826000844 KMSKS motif; other site 1041826000845 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1041826000846 anticodon binding site; other site 1041826000847 tRNA binding surface [nucleotide binding]; other site 1041826000848 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1041826000849 GTP cyclohydrolase I; Provisional; Region: PLN03044 1041826000850 active site 1041826000851 aspartate aminotransferase; Provisional; Region: PRK07568 1041826000852 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041826000853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826000854 homodimer interface [polypeptide binding]; other site 1041826000855 catalytic residue [active] 1041826000856 Cytochrome c; Region: Cytochrom_C; pfam00034 1041826000857 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1041826000858 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1041826000859 metal ion-dependent adhesion site (MIDAS); other site 1041826000860 MoxR-like ATPases [General function prediction only]; Region: COG0714 1041826000861 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1041826000862 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1041826000863 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1041826000864 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1041826000865 Cu(I) binding site [ion binding]; other site 1041826000866 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1041826000867 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1041826000868 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1041826000869 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1041826000870 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1041826000871 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1041826000872 Cytochrome c; Region: Cytochrom_C; pfam00034 1041826000873 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1041826000874 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1041826000875 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1041826000876 Binuclear center (active site) [active] 1041826000877 K-pathway; other site 1041826000878 Putative proton exit pathway; other site 1041826000879 Cytochrome c; Region: Cytochrom_C; pfam00034 1041826000880 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1041826000881 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1041826000882 Hemerythrin-like domain; Region: Hr-like; cd12108 1041826000883 OstA-like protein; Region: OstA_2; pfam13100 1041826000884 OstA-like protein; Region: OstA; cl00844 1041826000885 OstA-like protein; Region: OstA; cl00844 1041826000886 acetylornithine aminotransferase; Provisional; Region: PRK02627 1041826000887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1041826000888 inhibitor-cofactor binding pocket; inhibition site 1041826000889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826000890 catalytic residue [active] 1041826000891 TPR repeat; Region: TPR_11; pfam13414 1041826000892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000893 binding surface 1041826000894 TPR motif; other site 1041826000895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000896 binding surface 1041826000897 TPR motif; other site 1041826000898 TPR repeat; Region: TPR_11; pfam13414 1041826000899 TPR repeat; Region: TPR_11; pfam13414 1041826000900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000901 binding surface 1041826000902 TPR motif; other site 1041826000903 TPR repeat; Region: TPR_11; pfam13414 1041826000904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826000905 binding surface 1041826000906 TPR motif; other site 1041826000907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826000908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1041826000909 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1041826000910 ATP binding site [chemical binding]; other site 1041826000911 Mg2+ binding site [ion binding]; other site 1041826000912 G-X-G motif; other site 1041826000913 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1041826000914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826000915 active site 1041826000916 phosphorylation site [posttranslational modification] 1041826000917 intermolecular recognition site; other site 1041826000918 dimerization interface [polypeptide binding]; other site 1041826000919 Haemolytic domain; Region: Haemolytic; cl00506 1041826000920 Bacterial SH3 domain; Region: SH3_4; pfam06347 1041826000921 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1041826000922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1041826000923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1041826000924 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1041826000925 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1041826000926 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1041826000927 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1041826000928 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1041826000929 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1041826000930 substrate binding site [chemical binding]; other site 1041826000931 hexamer interface [polypeptide binding]; other site 1041826000932 metal binding site [ion binding]; metal-binding site 1041826000933 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1041826000934 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1041826000935 MutS domain III; Region: MutS_III; pfam05192 1041826000936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826000937 Walker A/P-loop; other site 1041826000938 ATP binding site [chemical binding]; other site 1041826000939 Q-loop/lid; other site 1041826000940 ABC transporter signature motif; other site 1041826000941 Walker B; other site 1041826000942 D-loop; other site 1041826000943 H-loop/switch region; other site 1041826000944 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1041826000945 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1041826000946 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1041826000947 active site 1041826000948 oxyanion hole [active] 1041826000949 catalytic triad [active] 1041826000950 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1041826000951 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1041826000952 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1041826000953 active site 1041826000954 oxyanion hole [active] 1041826000955 catalytic triad [active] 1041826000956 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1041826000957 ligand binding site [chemical binding]; other site 1041826000958 active site 1041826000959 UGI interface [polypeptide binding]; other site 1041826000960 catalytic site [active] 1041826000961 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1041826000962 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1041826000963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1041826000964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1041826000965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1041826000966 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1041826000967 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1041826000968 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1041826000969 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1041826000970 putative rRNA binding site [nucleotide binding]; other site 1041826000971 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1041826000972 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1041826000973 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1041826000974 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1041826000975 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1041826000976 tetramer interface [polypeptide binding]; other site 1041826000977 TPP-binding site [chemical binding]; other site 1041826000978 heterodimer interface [polypeptide binding]; other site 1041826000979 phosphorylation loop region [posttranslational modification] 1041826000980 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1041826000981 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1041826000982 alpha subunit interface [polypeptide binding]; other site 1041826000983 TPP binding site [chemical binding]; other site 1041826000984 heterodimer interface [polypeptide binding]; other site 1041826000985 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041826000986 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1041826000987 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1041826000988 metal binding site [ion binding]; metal-binding site 1041826000989 dimer interface [polypeptide binding]; other site 1041826000990 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1041826000991 putative acyl-acceptor binding pocket; other site 1041826000992 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1041826000993 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1041826000994 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1041826000995 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1041826000996 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1041826000997 active site 1041826000998 nucleophile elbow; other site 1041826000999 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1041826001000 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1041826001001 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826001002 catalytic residue [active] 1041826001003 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1041826001004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041826001005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041826001006 DNA binding residues [nucleotide binding] 1041826001007 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1041826001008 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1041826001009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041826001010 motif II; other site 1041826001011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1041826001012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041826001013 catalytic residue [active] 1041826001014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826001015 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1041826001016 Walker A motif; other site 1041826001017 ATP binding site [chemical binding]; other site 1041826001018 Walker B motif; other site 1041826001019 arginine finger; other site 1041826001020 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1041826001021 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1041826001022 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1041826001023 active site 1041826001024 catalytic triad [active] 1041826001025 oxyanion hole [active] 1041826001026 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826001027 Transposase domain (DUF772); Region: DUF772; pfam05598 1041826001028 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826001029 Homeodomain-like domain; Region: HTH_23; pfam13384 1041826001030 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826001031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1041826001032 hypothetical protein; Provisional; Region: PRK04233 1041826001033 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1041826001034 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826001035 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826001036 ligand binding site [chemical binding]; other site 1041826001037 flexible hinge region; other site 1041826001038 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1041826001039 putative switch regulator; other site 1041826001040 non-specific DNA interactions [nucleotide binding]; other site 1041826001041 DNA binding site [nucleotide binding] 1041826001042 sequence specific DNA binding site [nucleotide binding]; other site 1041826001043 putative cAMP binding site [chemical binding]; other site 1041826001044 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1041826001045 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826001046 active site residue [active] 1041826001047 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826001048 active site residue [active] 1041826001049 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1041826001050 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826001051 active site residue [active] 1041826001052 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826001053 active site residue [active] 1041826001054 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1041826001055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1041826001056 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1041826001057 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1041826001058 active site 1041826001059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1041826001060 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1041826001061 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1041826001062 tetramer interface [polypeptide binding]; other site 1041826001063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826001064 catalytic residue [active] 1041826001065 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1041826001066 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1041826001067 RF-1 domain; Region: RF-1; pfam00472 1041826001068 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1041826001069 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1041826001070 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1041826001071 Uncharacterized conserved protein [Function unknown]; Region: COG2433 1041826001072 putative transposase OrfB; Reviewed; Region: PHA02517 1041826001073 HTH-like domain; Region: HTH_21; pfam13276 1041826001074 Integrase core domain; Region: rve; pfam00665 1041826001075 Integrase core domain; Region: rve_3; pfam13683 1041826001076 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1041826001077 DNA-binding interface [nucleotide binding]; DNA binding site 1041826001078 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1041826001079 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1041826001080 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1041826001081 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1041826001082 FtsH Extracellular; Region: FtsH_ext; pfam06480 1041826001083 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1041826001084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826001085 Walker A motif; other site 1041826001086 ATP binding site [chemical binding]; other site 1041826001087 Walker B motif; other site 1041826001088 arginine finger; other site 1041826001089 Peptidase family M41; Region: Peptidase_M41; pfam01434 1041826001090 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1041826001091 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1041826001092 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1041826001093 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1041826001094 Acyl CoA binding protein; Region: ACBP; pfam00887 1041826001095 acyl-CoA binding pocket [chemical binding]; other site 1041826001096 CoA binding site [chemical binding]; other site 1041826001097 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1041826001098 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1041826001099 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1041826001100 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 1041826001101 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1041826001102 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826001103 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1041826001104 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1041826001105 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1041826001106 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1041826001107 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1041826001108 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1041826001109 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1041826001110 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1041826001111 active site 1041826001112 Zn binding site [ion binding]; other site 1041826001113 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826001114 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1041826001115 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1041826001116 dimer interface [polypeptide binding]; other site 1041826001117 putative functional site; other site 1041826001118 putative MPT binding site; other site 1041826001119 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1041826001120 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1041826001121 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1041826001122 GTP binding site; other site 1041826001123 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1041826001124 MoaE interaction surface [polypeptide binding]; other site 1041826001125 MoeB interaction surface [polypeptide binding]; other site 1041826001126 thiocarboxylated glycine; other site 1041826001127 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1041826001128 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1041826001129 ATP binding site [chemical binding]; other site 1041826001130 substrate interface [chemical binding]; other site 1041826001131 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826001132 active site residue [active] 1041826001133 potential frameshift: common BLAST hit: gi|319955044|ref|YP_004166311.1| molybdopterin biosynthesis moae protein 1041826001134 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 1041826001135 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 1041826001136 trimer interface [polypeptide binding]; other site 1041826001137 dimer interface [polypeptide binding]; other site 1041826001138 putative active site [active] 1041826001139 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1041826001140 MPT binding site; other site 1041826001141 trimer interface [polypeptide binding]; other site 1041826001142 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1041826001143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826001144 FeS/SAM binding site; other site 1041826001145 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1041826001146 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1041826001147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826001148 putative substrate translocation pore; other site 1041826001149 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1041826001150 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1041826001151 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1041826001152 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1041826001153 [4Fe-4S] binding site [ion binding]; other site 1041826001154 molybdopterin cofactor binding site; other site 1041826001155 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1041826001156 molybdopterin cofactor binding site; other site 1041826001157 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1041826001158 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1041826001159 iron-sulfur cluster [ion binding]; other site 1041826001160 [2Fe-2S] cluster binding site [ion binding]; other site 1041826001161 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 1041826001162 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 1041826001163 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1041826001164 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826001165 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826001166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826001167 ligand binding site [chemical binding]; other site 1041826001168 Rrf2 family protein; Region: rrf2_super; TIGR00738 1041826001169 Transcriptional regulator; Region: Rrf2; pfam02082 1041826001170 Transcriptional regulator; Region: Rrf2; cl17282 1041826001171 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826001172 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1041826001173 ligand binding site [chemical binding]; other site 1041826001174 flexible hinge region; other site 1041826001175 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1041826001176 putative switch regulator; other site 1041826001177 non-specific DNA interactions [nucleotide binding]; other site 1041826001178 DNA binding site [nucleotide binding] 1041826001179 sequence specific DNA binding site [nucleotide binding]; other site 1041826001180 putative cAMP binding site [chemical binding]; other site 1041826001181 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 1041826001182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826001183 TPR motif; other site 1041826001184 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1041826001185 Ligand Binding Site [chemical binding]; other site 1041826001186 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1041826001187 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1041826001188 acetyl-CoA synthetase; Provisional; Region: PRK00174 1041826001189 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1041826001190 active site 1041826001191 CoA binding site [chemical binding]; other site 1041826001192 acyl-activating enzyme (AAE) consensus motif; other site 1041826001193 AMP binding site [chemical binding]; other site 1041826001194 acetate binding site [chemical binding]; other site 1041826001195 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1041826001196 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1041826001197 active site 1041826001198 catalytic site [active] 1041826001199 substrate binding site [chemical binding]; other site 1041826001200 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1041826001201 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826001202 ligand binding site [chemical binding]; other site 1041826001203 flexible hinge region; other site 1041826001204 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1041826001205 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1041826001206 metal binding triad; other site 1041826001207 K+ potassium transporter; Region: K_trans; pfam02705 1041826001208 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1041826001209 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 1041826001210 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1041826001211 Zn binding site [ion binding]; other site 1041826001212 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826001213 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1041826001214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826001215 FeS/SAM binding site; other site 1041826001216 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1041826001217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826001218 Walker A/P-loop; other site 1041826001219 ATP binding site [chemical binding]; other site 1041826001220 Q-loop/lid; other site 1041826001221 ABC transporter signature motif; other site 1041826001222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826001223 Walker B; other site 1041826001224 D-loop; other site 1041826001225 H-loop/switch region; other site 1041826001226 ABC transporter; Region: ABC_tran_2; pfam12848 1041826001227 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826001228 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 1041826001229 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 1041826001230 Ligand Binding Site [chemical binding]; other site 1041826001231 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1041826001232 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1041826001233 generic binding surface II; other site 1041826001234 ssDNA binding site; other site 1041826001235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826001236 ATP binding site [chemical binding]; other site 1041826001237 putative Mg++ binding site [ion binding]; other site 1041826001238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826001239 nucleotide binding region [chemical binding]; other site 1041826001240 ATP-binding site [chemical binding]; other site 1041826001241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1041826001242 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 1041826001243 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1041826001244 active site 1041826001245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826001246 binding surface 1041826001247 TPR motif; other site 1041826001248 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1041826001249 UbiA prenyltransferase family; Region: UbiA; pfam01040 1041826001250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1041826001251 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1041826001252 substrate binding site [chemical binding]; other site 1041826001253 oxyanion hole (OAH) forming residues; other site 1041826001254 trimer interface [polypeptide binding]; other site 1041826001255 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1041826001256 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1041826001257 peptidase T; Region: peptidase-T; TIGR01882 1041826001258 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1041826001259 metal binding site [ion binding]; metal-binding site 1041826001260 dimer interface [polypeptide binding]; other site 1041826001261 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1041826001262 metal ion-dependent adhesion site (MIDAS); other site 1041826001263 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1041826001264 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1041826001265 NAD(P) binding site [chemical binding]; other site 1041826001266 homotetramer interface [polypeptide binding]; other site 1041826001267 homodimer interface [polypeptide binding]; other site 1041826001268 active site 1041826001269 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1041826001270 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1041826001271 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041826001272 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1041826001273 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1041826001274 inhibitor-cofactor binding pocket; inhibition site 1041826001275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826001276 catalytic residue [active] 1041826001277 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1041826001278 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1041826001279 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041826001280 polyphosphate kinase; Provisional; Region: PRK05443 1041826001281 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1041826001282 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1041826001283 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1041826001284 domain interface [polypeptide binding]; other site 1041826001285 active site 1041826001286 catalytic site [active] 1041826001287 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1041826001288 domain interface [polypeptide binding]; other site 1041826001289 active site 1041826001290 catalytic site [active] 1041826001291 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1041826001292 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1041826001293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1041826001294 Integrase core domain; Region: rve; pfam00665 1041826001295 Integrase core domain; Region: rve_3; pfam13683 1041826001296 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1041826001297 DNA-binding interface [nucleotide binding]; DNA binding site 1041826001298 Winged helix-turn helix; Region: HTH_29; pfam13551 1041826001299 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1041826001300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826001301 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1041826001302 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1041826001303 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1041826001304 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1041826001305 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1041826001306 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1041826001307 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1041826001308 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1041826001309 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1041826001310 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1041826001311 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1041826001312 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1041826001313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826001314 Walker A motif; other site 1041826001315 ATP binding site [chemical binding]; other site 1041826001316 Walker B motif; other site 1041826001317 arginine finger; other site 1041826001318 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1041826001319 metal ion-dependent adhesion site (MIDAS); other site 1041826001320 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1041826001321 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1041826001322 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1041826001323 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1041826001324 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1041826001325 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1041826001326 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1041826001327 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1041826001328 active site 1041826001329 SAM binding site [chemical binding]; other site 1041826001330 homodimer interface [polypeptide binding]; other site 1041826001331 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1041826001332 active site 1041826001333 putative homodimer interface [polypeptide binding]; other site 1041826001334 SAM binding site [chemical binding]; other site 1041826001335 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1041826001336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1041826001337 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1041826001338 putative FMN binding site [chemical binding]; other site 1041826001339 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1041826001340 active site 1041826001341 SAM binding site [chemical binding]; other site 1041826001342 homodimer interface [polypeptide binding]; other site 1041826001343 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1041826001344 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1041826001345 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1041826001346 active site 1041826001347 SAM binding site [chemical binding]; other site 1041826001348 homodimer interface [polypeptide binding]; other site 1041826001349 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1041826001350 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1041826001351 putative active site [active] 1041826001352 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1041826001353 putative active site [active] 1041826001354 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1041826001355 active site 1041826001356 SAM binding site [chemical binding]; other site 1041826001357 homodimer interface [polypeptide binding]; other site 1041826001358 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1041826001359 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1041826001360 putative NAD(P) binding site [chemical binding]; other site 1041826001361 High-affinity nickel-transport protein; Region: NicO; cl00964 1041826001362 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1041826001363 dimer interface [polypeptide binding]; other site 1041826001364 [2Fe-2S] cluster binding site [ion binding]; other site 1041826001365 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826001366 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826001367 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1041826001368 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1041826001369 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1041826001370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041826001371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826001372 homodimer interface [polypeptide binding]; other site 1041826001373 catalytic residue [active] 1041826001374 cobyric acid synthase; Provisional; Region: PRK00784 1041826001375 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041826001376 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1041826001377 catalytic triad [active] 1041826001378 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1041826001379 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1041826001380 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1041826001381 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041826001382 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1041826001383 catalytic triad [active] 1041826001384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826001385 Walker A/P-loop; other site 1041826001386 ATP binding site [chemical binding]; other site 1041826001387 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1041826001388 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1041826001389 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1041826001390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1041826001391 Walker A motif; other site 1041826001392 ATP binding site [chemical binding]; other site 1041826001393 Helix-turn-helix domain; Region: HTH_36; pfam13730 1041826001394 Helix-turn-helix domain; Region: HTH_17; pfam12728 1041826001395 RteC protein; Region: RteC; pfam09357 1041826001396 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 1041826001397 active site 1041826001398 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1041826001399 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826001400 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826001401 active site 1041826001402 DNA binding site [nucleotide binding] 1041826001403 Int/Topo IB signature motif; other site 1041826001404 Helix-turn-helix domain; Region: HTH_17; pfam12728 1041826001405 Helix-turn-helix domain; Region: HTH_17; cl17695 1041826001406 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1041826001407 S-adenosylmethionine binding site [chemical binding]; other site 1041826001408 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041826001409 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1041826001410 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1041826001411 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1041826001412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1041826001413 ATP binding site [chemical binding]; other site 1041826001414 putative Mg++ binding site [ion binding]; other site 1041826001415 Myosin heavy chain [Cytoskeleton]; Region: COG5022 1041826001416 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1041826001417 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1041826001418 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1041826001419 dimerization interface [polypeptide binding]; other site 1041826001420 active site 1041826001421 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1041826001422 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1041826001423 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1041826001424 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1041826001425 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1041826001426 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1041826001427 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1041826001428 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1041826001429 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1041826001430 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1041826001431 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1041826001432 dimer interface [polypeptide binding]; other site 1041826001433 catalytic triad [active] 1041826001434 peroxidatic and resolving cysteines [active] 1041826001435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041826001436 dimerization interface [polypeptide binding]; other site 1041826001437 putative DNA binding site [nucleotide binding]; other site 1041826001438 putative Zn2+ binding site [ion binding]; other site 1041826001439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826001440 S-adenosylmethionine binding site [chemical binding]; other site 1041826001441 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1041826001442 active site 1041826001443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1041826001444 catalytic residues [active] 1041826001445 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1041826001446 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1041826001447 dimer interface [polypeptide binding]; other site 1041826001448 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1041826001449 catalytic triad [active] 1041826001450 peroxidatic and resolving cysteines [active] 1041826001451 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1041826001452 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1041826001453 tetramer interface [polypeptide binding]; other site 1041826001454 heme binding pocket [chemical binding]; other site 1041826001455 NADPH binding site [chemical binding]; other site 1041826001456 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1041826001457 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1041826001458 tetramer interface [polypeptide binding]; other site 1041826001459 heme binding pocket [chemical binding]; other site 1041826001460 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1041826001461 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1041826001462 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1041826001463 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1041826001464 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1041826001465 dimer interface [polypeptide binding]; other site 1041826001466 FMN binding site [chemical binding]; other site 1041826001467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041826001468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041826001469 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1041826001470 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1041826001471 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 1041826001472 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1041826001473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826001474 Walker A/P-loop; other site 1041826001475 ATP binding site [chemical binding]; other site 1041826001476 Q-loop/lid; other site 1041826001477 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826001478 ABC transporter; Region: ABC_tran_2; pfam12848 1041826001479 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826001480 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1041826001481 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1041826001482 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 1041826001483 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1041826001484 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1041826001485 Probable Catalytic site; other site 1041826001486 metal-binding site 1041826001487 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 1041826001488 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826001489 ligand binding site [chemical binding]; other site 1041826001490 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1041826001491 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1041826001492 integral membrane protein; Region: integ_memb_HG; TIGR03954 1041826001493 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1041826001494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826001495 ATP binding site [chemical binding]; other site 1041826001496 putative Mg++ binding site [ion binding]; other site 1041826001497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826001498 nucleotide binding region [chemical binding]; other site 1041826001499 ATP-binding site [chemical binding]; other site 1041826001500 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1041826001501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826001502 active site 1041826001503 phosphorylation site [posttranslational modification] 1041826001504 intermolecular recognition site; other site 1041826001505 dimerization interface [polypeptide binding]; other site 1041826001506 LytTr DNA-binding domain; Region: LytTR; smart00850 1041826001507 2TM domain; Region: 2TM; pfam13239 1041826001508 2TM domain; Region: 2TM; pfam13239 1041826001509 Domain of unknown function (DUF373); Region: DUF373; cl12079 1041826001510 Histidine kinase; Region: His_kinase; pfam06580 1041826001511 2TM domain; Region: 2TM; pfam13239 1041826001512 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826001513 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826001514 Ion channel; Region: Ion_trans_2; pfam07885 1041826001515 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826001516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1041826001517 N-terminal plug; other site 1041826001518 ligand-binding site [chemical binding]; other site 1041826001519 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1041826001520 Imelysin; Region: Peptidase_M75; pfam09375 1041826001521 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1041826001522 active site 1041826001523 catalytic residues [active] 1041826001524 metal binding site [ion binding]; metal-binding site 1041826001525 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1041826001526 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1041826001527 quinone interaction residues [chemical binding]; other site 1041826001528 active site 1041826001529 catalytic residues [active] 1041826001530 FMN binding site [chemical binding]; other site 1041826001531 substrate binding site [chemical binding]; other site 1041826001532 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1041826001533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826001534 active site 1041826001535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041826001536 active site 1041826001537 WxcM-like, C-terminal; Region: FdtA; pfam05523 1041826001538 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041826001539 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1041826001540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826001541 active site 1041826001542 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1041826001543 membrane protein insertase; Provisional; Region: PRK01318 1041826001544 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1041826001545 CTP synthetase; Validated; Region: pyrG; PRK05380 1041826001546 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1041826001547 Catalytic site [active] 1041826001548 active site 1041826001549 UTP binding site [chemical binding]; other site 1041826001550 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1041826001551 active site 1041826001552 putative oxyanion hole; other site 1041826001553 catalytic triad [active] 1041826001554 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1041826001555 OsmC-like protein; Region: OsmC; pfam02566 1041826001556 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001557 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1041826001558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001559 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001561 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1041826001562 ligand binding site [chemical binding]; other site 1041826001563 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001565 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1041826001566 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001567 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826001568 GMP synthase; Reviewed; Region: guaA; PRK00074 1041826001569 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1041826001570 AMP/PPi binding site [chemical binding]; other site 1041826001571 candidate oxyanion hole; other site 1041826001572 catalytic triad [active] 1041826001573 potential glutamine specificity residues [chemical binding]; other site 1041826001574 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1041826001575 ATP Binding subdomain [chemical binding]; other site 1041826001576 Ligand Binding sites [chemical binding]; other site 1041826001577 Dimerization subdomain; other site 1041826001578 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826001579 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826001580 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 1041826001581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826001582 Walker A/P-loop; other site 1041826001583 ATP binding site [chemical binding]; other site 1041826001584 Q-loop/lid; other site 1041826001585 ABC transporter signature motif; other site 1041826001586 Walker B; other site 1041826001587 D-loop; other site 1041826001588 H-loop/switch region; other site 1041826001589 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1041826001590 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1041826001591 putative dimer interface [polypeptide binding]; other site 1041826001592 putative anticodon binding site; other site 1041826001593 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1041826001594 homodimer interface [polypeptide binding]; other site 1041826001595 motif 1; other site 1041826001596 motif 2; other site 1041826001597 active site 1041826001598 motif 3; other site 1041826001599 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1041826001600 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1041826001601 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1041826001602 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1041826001603 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1041826001604 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1041826001605 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1041826001606 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1041826001607 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1041826001608 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826001609 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1041826001610 Outer membrane efflux protein; Region: OEP; pfam02321 1041826001611 Outer membrane efflux protein; Region: OEP; pfam02321 1041826001612 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1041826001613 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1041826001614 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1041826001615 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1041826001616 active site 1041826001617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826001618 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1041826001619 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1041826001620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826001621 ATP binding site [chemical binding]; other site 1041826001622 putative Mg++ binding site [ion binding]; other site 1041826001623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826001624 nucleotide binding region [chemical binding]; other site 1041826001625 ATP-binding site [chemical binding]; other site 1041826001626 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1041826001627 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1041826001628 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1041826001629 Glutamate binding site [chemical binding]; other site 1041826001630 NAD binding site [chemical binding]; other site 1041826001631 catalytic residues [active] 1041826001632 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1041826001633 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1041826001634 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1041826001635 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1041826001636 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1041826001637 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1041826001638 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1041826001639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826001640 Walker A motif; other site 1041826001641 ATP binding site [chemical binding]; other site 1041826001642 Walker B motif; other site 1041826001643 arginine finger; other site 1041826001644 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1041826001645 active site 1041826001646 catalytic residues [active] 1041826001647 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1041826001648 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1041826001649 hypothetical protein; Reviewed; Region: PRK09588 1041826001650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1041826001651 WYL domain; Region: WYL; pfam13280 1041826001652 aspartate aminotransferase; Provisional; Region: PRK05764 1041826001653 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041826001654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826001655 homodimer interface [polypeptide binding]; other site 1041826001656 catalytic residue [active] 1041826001657 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1041826001658 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1041826001659 putative di-iron ligands [ion binding]; other site 1041826001660 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1041826001661 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1041826001662 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1041826001663 Peptidase family U32; Region: Peptidase_U32; pfam01136 1041826001664 Collagenase; Region: DUF3656; pfam12392 1041826001665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826001666 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1041826001667 Coenzyme A binding pocket [chemical binding]; other site 1041826001668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826001669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1041826001670 putative substrate translocation pore; other site 1041826001671 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1041826001672 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1041826001673 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1041826001674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826001675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1041826001676 putative substrate translocation pore; other site 1041826001677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1041826001678 PAS fold; Region: PAS_3; pfam08447 1041826001679 putative active site [active] 1041826001680 heme pocket [chemical binding]; other site 1041826001681 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1041826001682 putative nucleotide binding site [chemical binding]; other site 1041826001683 uridine monophosphate binding site [chemical binding]; other site 1041826001684 homohexameric interface [polypeptide binding]; other site 1041826001685 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1041826001686 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1041826001687 hinge region; other site 1041826001688 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1041826001689 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826001690 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826001691 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1041826001692 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826001693 elongation factor Ts; Provisional; Region: tsf; PRK09377 1041826001694 UBA/TS-N domain; Region: UBA; pfam00627 1041826001695 Elongation factor TS; Region: EF_TS; pfam00889 1041826001696 Elongation factor TS; Region: EF_TS; pfam00889 1041826001697 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1041826001698 rRNA interaction site [nucleotide binding]; other site 1041826001699 S8 interaction site; other site 1041826001700 putative laminin-1 binding site; other site 1041826001701 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1041826001702 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1041826001703 23S rRNA interface [nucleotide binding]; other site 1041826001704 L3 interface [polypeptide binding]; other site 1041826001705 DNA polymerase I; Provisional; Region: PRK05755 1041826001706 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1041826001707 active site 1041826001708 metal binding site 1 [ion binding]; metal-binding site 1041826001709 putative 5' ssDNA interaction site; other site 1041826001710 metal binding site 3; metal-binding site 1041826001711 metal binding site 2 [ion binding]; metal-binding site 1041826001712 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1041826001713 putative DNA binding site [nucleotide binding]; other site 1041826001714 putative metal binding site [ion binding]; other site 1041826001715 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1041826001716 active site 1041826001717 catalytic site [active] 1041826001718 substrate binding site [chemical binding]; other site 1041826001719 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1041826001720 active site 1041826001721 DNA binding site [nucleotide binding] 1041826001722 catalytic site [active] 1041826001723 phosphodiesterase YaeI; Provisional; Region: PRK11340 1041826001724 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1041826001725 putative active site [active] 1041826001726 putative metal binding site [ion binding]; other site 1041826001727 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1041826001728 catalytic residues [active] 1041826001729 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041826001730 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1041826001731 NodB motif; other site 1041826001732 active site 1041826001733 catalytic site [active] 1041826001734 metal binding site [ion binding]; metal-binding site 1041826001735 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 1041826001736 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1041826001737 potential protein location (hypothetical protein FCOL_03255 [Flavobacterium columnare ATCC 49512]) that overlaps RNA (tRNA-Q) 1041826001738 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 1041826001739 Peptidase S46; Region: Peptidase_S46; pfam10459 1041826001740 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041826001741 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1041826001742 Histidine kinase; Region: His_kinase; pfam06580 1041826001743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1041826001744 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1041826001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826001746 active site 1041826001747 phosphorylation site [posttranslational modification] 1041826001748 intermolecular recognition site; other site 1041826001749 dimerization interface [polypeptide binding]; other site 1041826001750 LytTr DNA-binding domain; Region: LytTR; smart00850 1041826001751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826001752 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1041826001753 Coenzyme A binding pocket [chemical binding]; other site 1041826001754 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1041826001755 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1041826001756 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1041826001757 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1041826001758 inhibitor-cofactor binding pocket; inhibition site 1041826001759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826001760 catalytic residue [active] 1041826001761 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1041826001762 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1041826001763 NAD binding site [chemical binding]; other site 1041826001764 homodimer interface [polypeptide binding]; other site 1041826001765 active site 1041826001766 substrate binding site [chemical binding]; other site 1041826001767 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1041826001768 phosphoglyceromutase; Provisional; Region: PRK05434 1041826001769 potential frameshift: common BLAST hit: gi|256819007|ref|YP_003140286.1| YD repeat-containing protein 1041826001770 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1041826001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1041826001772 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1041826001773 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1041826001774 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1041826001775 active site pocket [active] 1041826001776 oxyanion hole [active] 1041826001777 catalytic triad [active] 1041826001778 active site nucleophile [active] 1041826001779 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1041826001780 Zn binding site [ion binding]; other site 1041826001781 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1041826001782 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 1041826001783 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1041826001784 active site 1041826001785 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1041826001786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826001787 S-adenosylmethionine binding site [chemical binding]; other site 1041826001788 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1041826001789 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1041826001790 FMN binding site [chemical binding]; other site 1041826001791 substrate binding site [chemical binding]; other site 1041826001792 putative catalytic residue [active] 1041826001793 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1041826001794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826001795 FeS/SAM binding site; other site 1041826001796 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1041826001797 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1041826001798 Walker A/P-loop; other site 1041826001799 ATP binding site [chemical binding]; other site 1041826001800 Q-loop/lid; other site 1041826001801 ABC transporter signature motif; other site 1041826001802 Walker B; other site 1041826001803 D-loop; other site 1041826001804 H-loop/switch region; other site 1041826001805 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1041826001806 Prephenate dehydratase; Region: PDT; pfam00800 1041826001807 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1041826001808 putative L-Phe binding site [chemical binding]; other site 1041826001809 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1041826001810 Chorismate mutase type II; Region: CM_2; smart00830 1041826001811 GTPase RsgA; Reviewed; Region: PRK00098 1041826001812 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1041826001813 RNA binding site [nucleotide binding]; other site 1041826001814 homodimer interface [polypeptide binding]; other site 1041826001815 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1041826001816 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1041826001817 GTP/Mg2+ binding site [chemical binding]; other site 1041826001818 G4 box; other site 1041826001819 G5 box; other site 1041826001820 G1 box; other site 1041826001821 Switch I region; other site 1041826001822 G2 box; other site 1041826001823 G3 box; other site 1041826001824 Switch II region; other site 1041826001825 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1041826001826 putative active site [active] 1041826001827 dimerization interface [polypeptide binding]; other site 1041826001828 putative tRNAtyr binding site [nucleotide binding]; other site 1041826001829 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1041826001830 homodimer interface [polypeptide binding]; other site 1041826001831 metal binding site [ion binding]; metal-binding site 1041826001832 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1041826001833 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1041826001834 hinge; other site 1041826001835 active site 1041826001836 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1041826001837 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1041826001838 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1041826001839 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1041826001840 active site 1041826001841 substrate binding site [chemical binding]; other site 1041826001842 Mg2+ binding site [ion binding]; other site 1041826001843 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1041826001844 kynureninase; Region: kynureninase; TIGR01814 1041826001845 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826001846 catalytic residue [active] 1041826001847 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1041826001848 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1041826001849 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1041826001850 Zn binding site [ion binding]; other site 1041826001851 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826001852 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1041826001853 putative active site [active] 1041826001854 Mn binding site [ion binding]; other site 1041826001855 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1041826001856 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1041826001857 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1041826001858 active site 1041826001859 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1041826001860 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1041826001861 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1041826001862 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1041826001863 Cupin domain; Region: Cupin_2; cl17218 1041826001864 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1041826001865 Zonular occludens toxin (Zot); Region: Zot; cl17485 1041826001866 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1041826001867 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1041826001868 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1041826001869 PBP superfamily domain; Region: PBP_like_2; pfam12849 1041826001870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1041826001871 TPR motif; other site 1041826001872 binding surface 1041826001873 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1041826001874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826001875 FeS/SAM binding site; other site 1041826001876 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1041826001877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826001878 S-adenosylmethionine binding site [chemical binding]; other site 1041826001879 Flagellin N-methylase; Region: FliB; pfam03692 1041826001880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1041826001881 PAS domain; Region: PAS_9; pfam13426 1041826001882 putative active site [active] 1041826001883 heme pocket [chemical binding]; other site 1041826001884 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1041826001885 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1041826001886 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1041826001887 FtsX-like permease family; Region: FtsX; pfam02687 1041826001888 potential frameshift: common BLAST hit: gi|326796984|ref|YP_004314804.1| transposase mutator type 1041826001889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1041826001890 potential frameshift: common BLAST hit: gi|313207081|ref|YP_004046258.1| yd repeat protein 1041826001891 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826001892 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826001893 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1041826001894 dimer interface [polypeptide binding]; other site 1041826001895 Citrate synthase; Region: Citrate_synt; pfam00285 1041826001896 active site 1041826001897 citrylCoA binding site [chemical binding]; other site 1041826001898 NADH binding [chemical binding]; other site 1041826001899 cationic pore residues; other site 1041826001900 oxalacetate/citrate binding site [chemical binding]; other site 1041826001901 coenzyme A binding site [chemical binding]; other site 1041826001902 catalytic triad [active] 1041826001903 Arginase family; Region: Arginase; cd09989 1041826001904 active site 1041826001905 Mn binding site [ion binding]; other site 1041826001906 oligomer interface [polypeptide binding]; other site 1041826001907 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 1041826001908 Amidinotransferase; Region: Amidinotransf; pfam02274 1041826001909 MarC family integral membrane protein; Region: MarC; cl00919 1041826001910 CoA binding domain; Region: CoA_binding_2; pfam13380 1041826001911 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1041826001912 active site 1041826001913 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 1041826001914 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826001915 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 1041826001916 Na binding site [ion binding]; other site 1041826001917 recombination protein RecR; Reviewed; Region: recR; PRK00076 1041826001918 RecR protein; Region: RecR; pfam02132 1041826001919 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1041826001920 putative active site [active] 1041826001921 putative metal-binding site [ion binding]; other site 1041826001922 tetramer interface [polypeptide binding]; other site 1041826001923 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1041826001924 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1041826001925 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1041826001926 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1041826001927 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1041826001928 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041826001929 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1041826001930 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1041826001931 NAD binding site [chemical binding]; other site 1041826001932 substrate binding site [chemical binding]; other site 1041826001933 homodimer interface [polypeptide binding]; other site 1041826001934 active site 1041826001935 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1041826001936 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1041826001937 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1041826001938 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1041826001939 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 1041826001940 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1041826001941 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1041826001942 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1041826001943 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1041826001944 NAD binding site [chemical binding]; other site 1041826001945 substrate binding site [chemical binding]; other site 1041826001946 homodimer interface [polypeptide binding]; other site 1041826001947 active site 1041826001948 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1041826001949 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1041826001950 substrate binding site; other site 1041826001951 tetramer interface; other site 1041826001952 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1041826001953 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041826001954 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1041826001955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826001956 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826001957 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1041826001958 active site clefts [active] 1041826001959 zinc binding site [ion binding]; other site 1041826001960 dimer interface [polypeptide binding]; other site 1041826001961 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1041826001962 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1041826001963 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1041826001964 Heavy-metal-associated domain; Region: HMA; pfam00403 1041826001965 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826001966 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826001967 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1041826001968 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1041826001969 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1041826001970 GAF domain; Region: GAF_2; pfam13185 1041826001971 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1041826001972 16S/18S rRNA binding site [nucleotide binding]; other site 1041826001973 S13e-L30e interaction site [polypeptide binding]; other site 1041826001974 25S rRNA binding site [nucleotide binding]; other site 1041826001975 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1041826001976 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1041826001977 RNase E interface [polypeptide binding]; other site 1041826001978 trimer interface [polypeptide binding]; other site 1041826001979 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1041826001980 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1041826001981 RNase E interface [polypeptide binding]; other site 1041826001982 trimer interface [polypeptide binding]; other site 1041826001983 active site 1041826001984 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1041826001985 putative nucleic acid binding region [nucleotide binding]; other site 1041826001986 G-X-X-G motif; other site 1041826001987 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1041826001988 RNA binding site [nucleotide binding]; other site 1041826001989 domain interface; other site 1041826001990 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1041826001991 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1041826001992 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041826001993 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1041826001994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041826001995 DNA binding residues [nucleotide binding] 1041826001996 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1041826001997 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826001998 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1041826001999 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1041826002000 active site 1041826002001 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826002002 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1041826002003 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1041826002004 active site 1041826002005 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1041826002006 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1041826002007 Yqey-like protein; Region: YqeY; pfam09424 1041826002008 cell division protein FtsZ; Validated; Region: PRK09330 1041826002009 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1041826002010 nucleotide binding site [chemical binding]; other site 1041826002011 SulA interaction site; other site 1041826002012 cell division protein FtsA; Region: ftsA; TIGR01174 1041826002013 Cell division protein FtsA; Region: FtsA; smart00842 1041826002014 Cell division protein FtsA; Region: FtsA; pfam14450 1041826002015 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1041826002016 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1041826002017 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041826002018 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826002019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041826002020 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1041826002021 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1041826002022 active site 1041826002023 homodimer interface [polypeptide binding]; other site 1041826002024 cell division protein FtsW; Region: ftsW; TIGR02614 1041826002025 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1041826002026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826002027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041826002028 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1041826002029 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1041826002030 Mg++ binding site [ion binding]; other site 1041826002031 putative catalytic motif [active] 1041826002032 putative substrate binding site [chemical binding]; other site 1041826002033 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1041826002034 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041826002035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826002036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041826002037 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1041826002038 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1041826002039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1041826002040 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1041826002041 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1041826002042 MraW methylase family; Region: Methyltransf_5; cl17771 1041826002043 cell division protein MraZ; Reviewed; Region: PRK00326 1041826002044 MraZ protein; Region: MraZ; pfam02381 1041826002045 MraZ protein; Region: MraZ; pfam02381 1041826002046 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1041826002047 metal binding site 2 [ion binding]; metal-binding site 1041826002048 putative DNA binding helix; other site 1041826002049 metal binding site 1 [ion binding]; metal-binding site 1041826002050 dimer interface [polypeptide binding]; other site 1041826002051 structural Zn2+ binding site [ion binding]; other site 1041826002052 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1041826002053 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1041826002054 GDP-binding site [chemical binding]; other site 1041826002055 ACT binding site; other site 1041826002056 IMP binding site; other site 1041826002057 PGAP1-like protein; Region: PGAP1; pfam07819 1041826002058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041826002059 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1041826002060 G1 box; other site 1041826002061 GTP/Mg2+ binding site [chemical binding]; other site 1041826002062 Switch I region; other site 1041826002063 G2 box; other site 1041826002064 G3 box; other site 1041826002065 Switch II region; other site 1041826002066 G4 box; other site 1041826002067 G5 box; other site 1041826002068 gliding motility-associated protein GldC; Region: GldC; TIGR03515 1041826002069 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 1041826002070 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1041826002071 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1041826002072 homodimer interface [polypeptide binding]; other site 1041826002073 NAD binding pocket [chemical binding]; other site 1041826002074 ATP binding pocket [chemical binding]; other site 1041826002075 Mg binding site [ion binding]; other site 1041826002076 active-site loop [active] 1041826002077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1041826002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826002079 active site 1041826002080 phosphorylation site [posttranslational modification] 1041826002081 intermolecular recognition site; other site 1041826002082 dimerization interface [polypeptide binding]; other site 1041826002083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1041826002084 DNA binding residues [nucleotide binding] 1041826002085 dimerization interface [polypeptide binding]; other site 1041826002086 DNA primase; Validated; Region: dnaG; PRK05667 1041826002087 CHC2 zinc finger; Region: zf-CHC2; cl17510 1041826002088 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1041826002089 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1041826002090 active site 1041826002091 metal binding site [ion binding]; metal-binding site 1041826002092 interdomain interaction site; other site 1041826002093 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1041826002094 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1041826002095 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1041826002096 substrate binding pocket [chemical binding]; other site 1041826002097 chain length determination region; other site 1041826002098 substrate-Mg2+ binding site; other site 1041826002099 catalytic residues [active] 1041826002100 aspartate-rich region 1; other site 1041826002101 active site lid residues [active] 1041826002102 aspartate-rich region 2; other site 1041826002103 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1041826002104 FAD binding site [chemical binding]; other site 1041826002105 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1041826002106 substrate binding pocket [chemical binding]; other site 1041826002107 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1041826002108 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1041826002109 putative active site [active] 1041826002110 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1041826002111 B12 binding site [chemical binding]; other site 1041826002112 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1041826002113 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1041826002114 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1041826002115 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1041826002116 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 1041826002117 putative catalytic residues [active] 1041826002118 nucleotide binding site [chemical binding]; other site 1041826002119 aspartate binding site [chemical binding]; other site 1041826002120 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1041826002121 dimer interface [polypeptide binding]; other site 1041826002122 putative threonine allosteric regulatory site; other site 1041826002123 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1041826002124 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1041826002125 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1041826002126 potential frameshift: common BLAST hit: gi|295135453|ref|YP_003586129.1| aspartokinase 1041826002127 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1041826002128 Homeodomain-like domain; Region: HTH_23; pfam13384 1041826002129 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826002130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1041826002131 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1041826002132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826002133 binding surface 1041826002134 TPR repeat; Region: TPR_11; pfam13414 1041826002135 TPR motif; other site 1041826002136 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1041826002137 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826002138 TPR motif; other site 1041826002139 binding surface 1041826002140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826002141 binding surface 1041826002142 TPR motif; other site 1041826002143 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1041826002144 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1041826002145 DXD motif; other site 1041826002146 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1041826002147 potential frameshift: common BLAST hit: gi|45656012|ref|YP_000098.1| cystathionine gamma-synthase 1041826002148 potential frameshift: common BLAST hit: gi|157737956|ref|YP_001490640.1| cystathionine gamma-synthase 1041826002149 cystathionine beta-lyase, eukaryotic; Region: cysta_beta_ly_E; TIGR01329 1041826002150 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1041826002151 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1041826002152 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1041826002153 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1041826002154 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1041826002155 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1041826002156 Substrate-binding site [chemical binding]; other site 1041826002157 Substrate specificity [chemical binding]; other site 1041826002158 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1041826002159 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1041826002160 folate binding site [chemical binding]; other site 1041826002161 NADP+ binding site [chemical binding]; other site 1041826002162 2TM domain; Region: 2TM; pfam13239 1041826002163 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1041826002164 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1041826002165 dimerization interface [polypeptide binding]; other site 1041826002166 active site 1041826002167 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1041826002168 UvrB/uvrC motif; Region: UVR; pfam02151 1041826002169 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1041826002170 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1041826002171 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1041826002172 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1041826002173 Ligand binding site [chemical binding]; other site 1041826002174 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1041826002175 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1041826002176 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1041826002177 alpha subunit interface [polypeptide binding]; other site 1041826002178 TPP binding site [chemical binding]; other site 1041826002179 heterodimer interface [polypeptide binding]; other site 1041826002180 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041826002181 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826002182 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1041826002183 dimer interface [polypeptide binding]; other site 1041826002184 substrate binding site [chemical binding]; other site 1041826002185 metal binding sites [ion binding]; metal-binding site 1041826002186 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1041826002187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826002188 S-adenosylmethionine binding site [chemical binding]; other site 1041826002189 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826002190 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1041826002191 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041826002192 Surface antigen; Region: Bac_surface_Ag; pfam01103 1041826002193 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1041826002194 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1041826002195 active site 1041826002196 intersubunit interface [polypeptide binding]; other site 1041826002197 zinc binding site [ion binding]; other site 1041826002198 Na+ binding site [ion binding]; other site 1041826002199 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1041826002200 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1041826002201 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1041826002202 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1041826002203 FtsX-like permease family; Region: FtsX; pfam02687 1041826002204 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1041826002205 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1041826002206 purine monophosphate binding site [chemical binding]; other site 1041826002207 dimer interface [polypeptide binding]; other site 1041826002208 putative catalytic residues [active] 1041826002209 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1041826002210 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1041826002211 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1041826002212 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1041826002213 dimer interface [polypeptide binding]; other site 1041826002214 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1041826002215 catalytic triad [active] 1041826002216 peroxidatic and resolving cysteines [active] 1041826002217 rod shape-determining protein MreB; Provisional; Region: PRK13927 1041826002218 MreB and similar proteins; Region: MreB_like; cd10225 1041826002219 nucleotide binding site [chemical binding]; other site 1041826002220 Mg binding site [ion binding]; other site 1041826002221 putative protofilament interaction site [polypeptide binding]; other site 1041826002222 RodZ interaction site [polypeptide binding]; other site 1041826002223 rod shape-determining protein MreC; Provisional; Region: PRK13922 1041826002224 rod shape-determining protein MreC; Region: MreC; pfam04085 1041826002225 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1041826002226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1041826002227 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1041826002228 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1041826002229 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1041826002230 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1041826002231 active site 1041826002232 substrate binding site [chemical binding]; other site 1041826002233 Mg2+ binding site [ion binding]; other site 1041826002234 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1041826002235 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1041826002236 homodimer interface [polypeptide binding]; other site 1041826002237 catalytic residues [active] 1041826002238 NAD binding site [chemical binding]; other site 1041826002239 substrate binding pocket [chemical binding]; other site 1041826002240 flexible flap; other site 1041826002241 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1041826002242 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1041826002243 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041826002244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826002245 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1041826002246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826002247 putative substrate translocation pore; other site 1041826002248 POT family; Region: PTR2; cl17359 1041826002249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826002250 putative substrate translocation pore; other site 1041826002251 POT family; Region: PTR2; cl17359 1041826002252 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1041826002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826002254 putative substrate translocation pore; other site 1041826002255 POT family; Region: PTR2; cl17359 1041826002256 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1041826002257 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 1041826002258 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1041826002259 Competence protein; Region: Competence; pfam03772 1041826002260 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1041826002261 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1041826002262 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1041826002263 carboxy-terminal protease; Provisional; Region: PRK11186 1041826002264 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1041826002265 protein binding site [polypeptide binding]; other site 1041826002266 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1041826002267 Catalytic dyad [active] 1041826002268 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1041826002269 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826002270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1041826002271 Homeodomain-like domain; Region: HTH_23; pfam13384 1041826002272 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1041826002273 AsmA family; Region: AsmA; pfam05170 1041826002274 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1041826002275 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1041826002276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041826002277 RNA binding surface [nucleotide binding]; other site 1041826002278 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1041826002279 active site 1041826002280 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1041826002281 UbiA prenyltransferase family; Region: UbiA; pfam01040 1041826002282 mevalonate kinase; Region: mevalon_kin; TIGR00549 1041826002283 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1041826002284 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1041826002285 diphosphomevalonate decarboxylase; Region: PLN02407 1041826002286 flavoprotein, HI0933 family; Region: TIGR00275 1041826002287 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 1041826002288 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1041826002289 active site 1041826002290 catalytic site [active] 1041826002291 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1041826002292 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1041826002293 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826002294 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 1041826002295 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1041826002296 nucleotide binding site [chemical binding]; other site 1041826002297 substrate binding site [chemical binding]; other site 1041826002298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826002299 Coenzyme A binding pocket [chemical binding]; other site 1041826002300 Peptidase family M48; Region: Peptidase_M48; cl12018 1041826002301 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1041826002302 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1041826002303 AMP binding site [chemical binding]; other site 1041826002304 metal binding site [ion binding]; metal-binding site 1041826002305 active site 1041826002306 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1041826002307 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1041826002308 catalytic residue [active] 1041826002309 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1041826002310 SurA N-terminal domain; Region: SurA_N_3; cl07813 1041826002311 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1041826002312 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1041826002313 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1041826002314 pantothenate kinase; Reviewed; Region: PRK13320 1041826002315 potential protein location (hypothetical protein FCOL_04395 [Flavobacterium columnare ATCC 49512]) that overlaps RNA (tRNA-F) 1041826002316 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826002317 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826002318 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1041826002319 MutS domain I; Region: MutS_I; pfam01624 1041826002320 MutS domain II; Region: MutS_II; pfam05188 1041826002321 MutS domain III; Region: MutS_III; pfam05192 1041826002322 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1041826002323 Walker A/P-loop; other site 1041826002324 ATP binding site [chemical binding]; other site 1041826002325 Q-loop/lid; other site 1041826002326 ABC transporter signature motif; other site 1041826002327 Walker B; other site 1041826002328 D-loop; other site 1041826002329 H-loop/switch region; other site 1041826002330 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 1041826002331 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041826002332 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1041826002333 catalytic center binding site [active] 1041826002334 ATP binding site [chemical binding]; other site 1041826002335 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1041826002336 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1041826002337 Substrate-binding site [chemical binding]; other site 1041826002338 Substrate specificity [chemical binding]; other site 1041826002339 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1041826002340 tandem repeat interface [polypeptide binding]; other site 1041826002341 oligomer interface [polypeptide binding]; other site 1041826002342 active site residues [active] 1041826002343 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1041826002344 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1041826002345 tandem repeat interface [polypeptide binding]; other site 1041826002346 oligomer interface [polypeptide binding]; other site 1041826002347 active site residues [active] 1041826002348 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1041826002349 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1041826002350 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1041826002351 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1041826002352 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1041826002353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826002354 Walker A motif; other site 1041826002355 ATP binding site [chemical binding]; other site 1041826002356 Walker B motif; other site 1041826002357 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1041826002358 Clp protease; Region: CLP_protease; pfam00574 1041826002359 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1041826002360 oligomer interface [polypeptide binding]; other site 1041826002361 active site residues [active] 1041826002362 trigger factor; Region: tig; TIGR00115 1041826002363 Membrane protein of unknown function; Region: DUF360; pfam04020 1041826002364 PGAP1-like protein; Region: PGAP1; pfam07819 1041826002365 acyl-CoA esterase; Provisional; Region: PRK10673 1041826002366 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1041826002367 active site 1041826002368 hydrophilic channel; other site 1041826002369 dimerization interface [polypeptide binding]; other site 1041826002370 catalytic residues [active] 1041826002371 active site lid [active] 1041826002372 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1041826002373 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 1041826002374 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1041826002375 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826002376 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1041826002377 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1041826002378 catalytic residue [active] 1041826002379 putative FPP diphosphate binding site; other site 1041826002380 putative FPP binding hydrophobic cleft; other site 1041826002381 dimer interface [polypeptide binding]; other site 1041826002382 putative IPP diphosphate binding site; other site 1041826002383 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1041826002384 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1041826002385 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1041826002386 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1041826002387 Surface antigen; Region: Bac_surface_Ag; pfam01103 1041826002388 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1041826002389 periplasmic chaperone; Provisional; Region: PRK10780 1041826002390 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1041826002391 glutamate racemase; Provisional; Region: PRK00865 1041826002392 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1041826002393 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1041826002394 trimer interface [polypeptide binding]; other site 1041826002395 putative metal binding site [ion binding]; other site 1041826002396 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 1041826002397 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1041826002398 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1041826002399 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1041826002400 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1041826002401 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1041826002402 Glycoprotease family; Region: Peptidase_M22; pfam00814 1041826002403 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1041826002404 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041826002405 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826002406 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1041826002407 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 1041826002408 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1041826002409 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1041826002410 Cu(I) binding site [ion binding]; other site 1041826002411 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 1041826002412 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1041826002413 Subunit I/III interface [polypeptide binding]; other site 1041826002414 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1041826002415 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1041826002416 Subunit I/III interface [polypeptide binding]; other site 1041826002417 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1041826002418 UbiA prenyltransferase family; Region: UbiA; pfam01040 1041826002419 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 1041826002420 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 1041826002421 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1041826002422 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826002423 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826002424 ligand binding site [chemical binding]; other site 1041826002425 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1041826002426 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1041826002427 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1041826002428 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1041826002429 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1041826002430 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1041826002431 MoxR-like ATPases [General function prediction only]; Region: COG0714 1041826002432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826002433 Walker A motif; other site 1041826002434 ATP binding site [chemical binding]; other site 1041826002435 Walker B motif; other site 1041826002436 arginine finger; other site 1041826002437 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1041826002438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826002439 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1041826002440 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 1041826002441 substrate binding site [chemical binding]; other site 1041826002442 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1041826002443 substrate binding site [chemical binding]; other site 1041826002444 ligand binding site [chemical binding]; other site 1041826002445 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826002446 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826002447 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826002448 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826002449 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826002450 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826002451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826002452 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1041826002453 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1041826002454 Interdomain contacts; other site 1041826002455 Cytokine receptor motif; other site 1041826002456 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1041826002457 Active_site [active] 1041826002458 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 1041826002459 Active_site [active] 1041826002460 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1041826002461 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826002462 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826002463 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1041826002464 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826002465 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1041826002466 NlpC/P60 family; Region: NLPC_P60; pfam00877 1041826002467 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1041826002468 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1041826002469 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1041826002470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1041826002471 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1041826002472 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1041826002473 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1041826002474 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1041826002475 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1041826002476 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041826002477 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1041826002478 protein binding site [polypeptide binding]; other site 1041826002479 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1041826002480 protein binding site [polypeptide binding]; other site 1041826002481 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1041826002482 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1041826002483 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1041826002484 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1041826002485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826002486 Coenzyme A binding pocket [chemical binding]; other site 1041826002487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1041826002488 YceG-like family; Region: YceG; pfam02618 1041826002489 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1041826002490 dimerization interface [polypeptide binding]; other site 1041826002491 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 1041826002492 putative SAM binding site [chemical binding]; other site 1041826002493 homodimer interface [polypeptide binding]; other site 1041826002494 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1041826002495 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1041826002496 active site 1041826002497 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1041826002498 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1041826002499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826002500 Walker A motif; other site 1041826002501 ATP binding site [chemical binding]; other site 1041826002502 Walker B motif; other site 1041826002503 arginine finger; other site 1041826002504 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1041826002505 DnaA box-binding interface [nucleotide binding]; other site 1041826002506 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1041826002507 active site 1041826002508 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1041826002509 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1041826002510 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1041826002511 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1041826002512 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1041826002513 catalytic motif [active] 1041826002514 Zn binding site [ion binding]; other site 1041826002515 RibD C-terminal domain; Region: RibD_C; pfam01872 1041826002516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826002517 Coenzyme A binding pocket [chemical binding]; other site 1041826002518 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1041826002519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826002520 S-adenosylmethionine binding site [chemical binding]; other site 1041826002521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1041826002522 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1041826002523 FtsX-like permease family; Region: FtsX; pfam02687 1041826002524 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1041826002525 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1041826002526 dimer interface [polypeptide binding]; other site 1041826002527 motif 1; other site 1041826002528 active site 1041826002529 motif 2; other site 1041826002530 motif 3; other site 1041826002531 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1041826002532 anticodon binding site; other site 1041826002533 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826002534 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1041826002535 active site 1041826002536 DNA binding site [nucleotide binding] 1041826002537 Int/Topo IB signature motif; other site 1041826002538 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826002539 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1041826002540 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1041826002541 trimer interface [polypeptide binding]; other site 1041826002542 active site 1041826002543 dimer interface [polypeptide binding]; other site 1041826002544 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1041826002545 hypothetical protein; Provisional; Region: PRK10621 1041826002546 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1041826002547 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1041826002548 hinge; other site 1041826002549 active site 1041826002550 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 1041826002551 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1041826002552 Predicted ATPase [General function prediction only]; Region: COG3911 1041826002553 AAA domain; Region: AAA_28; pfam13521 1041826002554 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1041826002555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826002556 ATP binding site [chemical binding]; other site 1041826002557 putative Mg++ binding site [ion binding]; other site 1041826002558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826002559 nucleotide binding region [chemical binding]; other site 1041826002560 ATP-binding site [chemical binding]; other site 1041826002561 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1041826002562 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1041826002563 putative active site [active] 1041826002564 substrate binding site [chemical binding]; other site 1041826002565 putative cosubstrate binding site; other site 1041826002566 catalytic site [active] 1041826002567 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1041826002568 substrate binding site [chemical binding]; other site 1041826002569 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1041826002570 IHF - DNA interface [nucleotide binding]; other site 1041826002571 IHF dimer interface [polypeptide binding]; other site 1041826002572 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1041826002573 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1041826002574 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1041826002575 homodimer interface [polypeptide binding]; other site 1041826002576 substrate-cofactor binding pocket; other site 1041826002577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826002578 catalytic residue [active] 1041826002579 PAS fold; Region: PAS_3; pfam08447 1041826002580 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1041826002581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826002582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826002583 ATP binding site [chemical binding]; other site 1041826002584 Mg2+ binding site [ion binding]; other site 1041826002585 G-X-G motif; other site 1041826002586 phosphodiesterase; Provisional; Region: PRK12704 1041826002587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041826002588 Zn2+ binding site [ion binding]; other site 1041826002589 Mg2+ binding site [ion binding]; other site 1041826002590 Cell division protein ZapA; Region: ZapA; pfam05164 1041826002591 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1041826002592 potential frameshift: common BLAST hit: gi|150025215|ref|YP_001296041.1| secreted M23/M37 family peptidase 1041826002593 potential frameshift: common BLAST hit: gi|150025214|ref|YP_001296040.1| outer membrane protein 1041826002594 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041826002595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041826002596 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1041826002597 Walker A/P-loop; other site 1041826002598 ATP binding site [chemical binding]; other site 1041826002599 Q-loop/lid; other site 1041826002600 ABC transporter signature motif; other site 1041826002601 Walker B; other site 1041826002602 D-loop; other site 1041826002603 H-loop/switch region; other site 1041826002604 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1041826002605 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1041826002606 active site 1041826002607 substrate binding site [chemical binding]; other site 1041826002608 metal binding site [ion binding]; metal-binding site 1041826002609 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1041826002610 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1041826002611 Ligand binding site; other site 1041826002612 Putative Catalytic site; other site 1041826002613 DXD motif; other site 1041826002614 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1041826002615 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1041826002616 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 1041826002617 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 1041826002618 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 1041826002619 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1041826002620 Aspartase; Region: Aspartase; cd01357 1041826002621 active sites [active] 1041826002622 tetramer interface [polypeptide binding]; other site 1041826002623 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826002624 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826002625 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1041826002626 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1041826002627 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1041826002628 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826002629 catalytic triad [active] 1041826002630 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1041826002631 active site 1041826002632 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1041826002633 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1041826002634 active site 1041826002635 metal binding site [ion binding]; metal-binding site 1041826002636 nudix motif; other site 1041826002637 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1041826002638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041826002639 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1041826002640 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1041826002641 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 1041826002642 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1041826002643 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1041826002644 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1041826002645 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 1041826002646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041826002647 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1041826002648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041826002649 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1041826002650 substrate binding site [chemical binding]; other site 1041826002651 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 1041826002652 potential frameshift: common BLAST hit: gi|146297859|ref|YP_001192450.1| peptidase S41 1041826002653 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1041826002654 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826002655 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1041826002656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1041826002657 catalytic core [active] 1041826002658 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1041826002659 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1041826002660 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1041826002661 putative dimer interface [polypeptide binding]; other site 1041826002662 active site pocket [active] 1041826002663 putative cataytic base [active] 1041826002664 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 1041826002665 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 1041826002666 Ligand Binding Site [chemical binding]; other site 1041826002667 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1041826002668 homotrimer interface [polypeptide binding]; other site 1041826002669 Walker A motif; other site 1041826002670 GTP binding site [chemical binding]; other site 1041826002671 Walker B motif; other site 1041826002672 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1041826002673 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1041826002674 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 1041826002675 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1041826002676 putative ligand binding site [chemical binding]; other site 1041826002677 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1041826002678 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1041826002679 ABC-ATPase subunit interface; other site 1041826002680 dimer interface [polypeptide binding]; other site 1041826002681 putative PBP binding regions; other site 1041826002682 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1041826002683 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1041826002684 Walker A/P-loop; other site 1041826002685 ATP binding site [chemical binding]; other site 1041826002686 Q-loop/lid; other site 1041826002687 ABC transporter signature motif; other site 1041826002688 Walker B; other site 1041826002689 D-loop; other site 1041826002690 H-loop/switch region; other site 1041826002691 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1041826002692 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1041826002693 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1041826002694 pseudouridine synthase; Region: TIGR00093 1041826002695 active site 1041826002696 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1041826002697 active site 1041826002698 NTP binding site [chemical binding]; other site 1041826002699 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1041826002700 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1041826002701 active site 1041826002702 nucleic acid binding site [nucleotide binding]; other site 1041826002703 nucleic acid binding site [nucleotide binding]; other site 1041826002704 RmuC family; Region: RmuC; pfam02646 1041826002705 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1041826002706 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1041826002707 YceI-like domain; Region: YceI; pfam04264 1041826002708 Inward rectifier potassium channel; Region: IRK; pfam01007 1041826002709 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1041826002710 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826002711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826002712 ligand binding site [chemical binding]; other site 1041826002713 flexible hinge region; other site 1041826002714 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1041826002715 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1041826002716 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1041826002717 Cl- selectivity filter; other site 1041826002718 Cl- binding residues [ion binding]; other site 1041826002719 pore gating glutamate residue; other site 1041826002720 dimer interface [polypeptide binding]; other site 1041826002721 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1041826002722 FOG: CBS domain [General function prediction only]; Region: COG0517 1041826002723 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1041826002724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1041826002725 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1041826002726 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041826002727 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1041826002728 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 1041826002729 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1041826002730 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 1041826002731 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041826002732 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1041826002733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1041826002734 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826002735 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1041826002736 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1041826002737 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1041826002738 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1041826002739 catalytic residue [active] 1041826002740 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1041826002741 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1041826002742 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826002743 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826002744 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041826002745 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041826002746 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1041826002747 active site 1041826002748 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1041826002749 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826002750 putative acyl-acceptor binding pocket; other site 1041826002751 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1041826002752 active site 1041826002753 homodimer interface [polypeptide binding]; other site 1041826002754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826002755 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1041826002756 active site 1041826002757 catalytic residues [active] 1041826002758 DNA binding site [nucleotide binding] 1041826002759 Int/Topo IB signature motif; other site 1041826002760 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1041826002761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1041826002762 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1041826002763 ParB-like nuclease domain; Region: ParBc; pfam02195 1041826002764 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1041826002765 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1041826002766 Active Sites [active] 1041826002767 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1041826002768 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1041826002769 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1041826002770 Holin family; Region: Phage_holin_4; cl01989 1041826002771 Terminase-like family; Region: Terminase_6; pfam03237 1041826002772 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1041826002773 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1041826002774 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1041826002775 oligomer interface [polypeptide binding]; other site 1041826002776 tandem repeat interface [polypeptide binding]; other site 1041826002777 active site residues [active] 1041826002778 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1041826002779 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1041826002780 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826002781 active site 1041826002782 DNA binding site [nucleotide binding] 1041826002783 Int/Topo IB signature motif; other site 1041826002784 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1041826002785 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1041826002786 cofactor binding site; other site 1041826002787 DNA binding site [nucleotide binding] 1041826002788 substrate interaction site [chemical binding]; other site 1041826002789 DNA primase, catalytic core; Region: dnaG; TIGR01391 1041826002790 CHC2 zinc finger; Region: zf-CHC2; cl17510 1041826002791 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1041826002792 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1041826002793 active site 1041826002794 metal binding site [ion binding]; metal-binding site 1041826002795 interdomain interaction site; other site 1041826002796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1041826002797 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1041826002798 DNA binding residues [nucleotide binding] 1041826002799 dimerization interface [polypeptide binding]; other site 1041826002800 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 1041826002801 catalytic residues [active] 1041826002802 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826002803 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826002804 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826002805 The ectodomain of Methuselah (Mth); Mth mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage; The protein affected by this mutation is related to G...; Region: Mth_Ecto; cl11637 1041826002806 putative transmembrane domain interaction surface; other site 1041826002807 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1041826002808 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826002809 Helix-turn-helix domain; Region: HTH_28; pfam13518 1041826002810 Winged helix-turn helix; Region: HTH_29; pfam13551 1041826002811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1041826002812 Integrase core domain; Region: rve; pfam00665 1041826002813 Integrase core domain; Region: rve_3; pfam13683 1041826002814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1041826002815 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1041826002816 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1041826002817 Transposase domain (DUF772); Region: DUF772; pfam05598 1041826002818 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826002819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1041826002820 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1041826002821 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 1041826002822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826002823 active site 1041826002824 DNA binding site [nucleotide binding] 1041826002825 Int/Topo IB signature motif; other site 1041826002826 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826002827 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826002828 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826002829 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826002830 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826002831 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 1041826002832 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1041826002833 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1041826002834 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826002835 active site 1041826002836 HIGH motif; other site 1041826002837 nucleotide binding site [chemical binding]; other site 1041826002838 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1041826002839 KMSK motif region; other site 1041826002840 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1041826002841 tRNA binding surface [nucleotide binding]; other site 1041826002842 anticodon binding site; other site 1041826002843 excinuclease ABC subunit B; Provisional; Region: PRK05298 1041826002844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826002845 ATP binding site [chemical binding]; other site 1041826002846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826002847 nucleotide binding region [chemical binding]; other site 1041826002848 ATP-binding site [chemical binding]; other site 1041826002849 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1041826002850 Thiamine pyrophosphokinase; Region: TPK; cd07995 1041826002851 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1041826002852 active site 1041826002853 dimerization interface [polypeptide binding]; other site 1041826002854 thiamine binding site [chemical binding]; other site 1041826002855 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 1041826002856 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826002857 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826002858 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826002859 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1041826002860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1041826002861 DNA-binding site [nucleotide binding]; DNA binding site 1041826002862 NlpE N-terminal domain; Region: NlpE; pfam04170 1041826002863 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826002864 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826002865 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1041826002866 active site 1041826002867 Zn binding site [ion binding]; other site 1041826002868 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1041826002869 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1041826002870 SelR domain; Region: SelR; pfam01641 1041826002871 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1041826002872 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1041826002873 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1041826002874 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1041826002875 putative tRNA-binding site [nucleotide binding]; other site 1041826002876 B3/4 domain; Region: B3_4; pfam03483 1041826002877 tRNA synthetase B5 domain; Region: B5; pfam03484 1041826002878 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1041826002879 dimer interface [polypeptide binding]; other site 1041826002880 motif 1; other site 1041826002881 motif 3; other site 1041826002882 motif 2; other site 1041826002883 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1041826002884 fumarylacetoacetase; Region: PLN02856 1041826002885 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1041826002886 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1041826002887 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1041826002888 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1041826002889 dimer interface [polypeptide binding]; other site 1041826002890 active site 1041826002891 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1041826002892 folate binding site [chemical binding]; other site 1041826002893 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1041826002894 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1041826002895 Tetramer interface [polypeptide binding]; other site 1041826002896 active site 1041826002897 FMN-binding site [chemical binding]; other site 1041826002898 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1041826002899 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1041826002900 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1041826002901 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1041826002902 Helix-turn-helix domain; Region: HTH_18; pfam12833 1041826002903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041826002904 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1041826002905 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1041826002906 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826002907 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826002908 ligand binding site [chemical binding]; other site 1041826002909 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1041826002910 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1041826002911 potential catalytic triad [active] 1041826002912 conserved cys residue [active] 1041826002913 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1041826002914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1041826002915 putative metal binding site [ion binding]; other site 1041826002916 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1041826002917 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1041826002918 dimer interface [polypeptide binding]; other site 1041826002919 active site 1041826002920 heme binding site [chemical binding]; other site 1041826002921 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1041826002922 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1041826002923 tetramer interface [polypeptide binding]; other site 1041826002924 TPP-binding site [chemical binding]; other site 1041826002925 heterodimer interface [polypeptide binding]; other site 1041826002926 phosphorylation loop region [posttranslational modification] 1041826002927 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1041826002928 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1041826002929 PYR/PP interface [polypeptide binding]; other site 1041826002930 dimer interface [polypeptide binding]; other site 1041826002931 TPP binding site [chemical binding]; other site 1041826002932 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041826002933 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1041826002934 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041826002935 metal binding site [ion binding]; metal-binding site 1041826002936 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826002937 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1041826002938 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1041826002939 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1041826002940 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1041826002941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041826002942 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1041826002943 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1041826002944 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1041826002945 catalytic residues [active] 1041826002946 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1041826002947 putative catalytic residues [active] 1041826002948 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826002949 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826002950 ligand binding site [chemical binding]; other site 1041826002951 flexible hinge region; other site 1041826002952 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1041826002953 putative switch regulator; other site 1041826002954 non-specific DNA interactions [nucleotide binding]; other site 1041826002955 DNA binding site [nucleotide binding] 1041826002956 sequence specific DNA binding site [nucleotide binding]; other site 1041826002957 putative cAMP binding site [chemical binding]; other site 1041826002958 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1041826002959 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1041826002960 E-class dimer interface [polypeptide binding]; other site 1041826002961 P-class dimer interface [polypeptide binding]; other site 1041826002962 active site 1041826002963 Cu2+ binding site [ion binding]; other site 1041826002964 Zn2+ binding site [ion binding]; other site 1041826002965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1041826002966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1041826002967 active site 1041826002968 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1041826002969 four helix bundle protein; Region: TIGR02436 1041826002970 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1041826002971 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1041826002972 dimer interface [polypeptide binding]; other site 1041826002973 active site 1041826002974 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1041826002975 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1041826002976 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1041826002977 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1041826002978 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1041826002979 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1041826002980 substrate binding site [chemical binding]; other site 1041826002981 oxyanion hole (OAH) forming residues; other site 1041826002982 trimer interface [polypeptide binding]; other site 1041826002983 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1041826002984 MarR family; Region: MarR_2; pfam12802 1041826002985 MarR family; Region: MarR_2; cl17246 1041826002986 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1041826002987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1041826002988 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1041826002989 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1041826002990 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 1041826002991 active site 1041826002992 catalytic triad [active] 1041826002993 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826002994 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1041826002995 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1041826002996 FMN binding site [chemical binding]; other site 1041826002997 substrate binding site [chemical binding]; other site 1041826002998 putative catalytic residue [active] 1041826002999 NAD-dependent deacetylase; Provisional; Region: PRK00481 1041826003000 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1041826003001 NAD+ binding site [chemical binding]; other site 1041826003002 substrate binding site [chemical binding]; other site 1041826003003 Zn binding site [ion binding]; other site 1041826003004 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041826003005 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 1041826003006 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826003007 putative acyl-acceptor binding pocket; other site 1041826003008 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 1041826003009 putative active site [active] 1041826003010 Zn binding site [ion binding]; other site 1041826003011 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1041826003012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041826003013 putative DNA binding site [nucleotide binding]; other site 1041826003014 putative Zn2+ binding site [ion binding]; other site 1041826003015 AsnC family; Region: AsnC_trans_reg; pfam01037 1041826003016 Domain of unknown function (DUF4348); Region: DUF4348; pfam14254 1041826003017 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 1041826003018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826003019 FeS/SAM binding site; other site 1041826003020 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1041826003021 B12 binding site [chemical binding]; other site 1041826003022 cobalt ligand [ion binding]; other site 1041826003023 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1041826003024 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041826003025 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1041826003026 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1041826003027 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826003028 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826003029 Homeodomain-like domain; Region: HTH_23; pfam13384 1041826003030 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826003031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1041826003032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826003033 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1041826003034 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1041826003035 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1041826003036 hexamer interface [polypeptide binding]; other site 1041826003037 ligand binding site [chemical binding]; other site 1041826003038 putative active site [active] 1041826003039 NAD(P) binding site [chemical binding]; other site 1041826003040 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1041826003041 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1041826003042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826003043 Coenzyme A binding pocket [chemical binding]; other site 1041826003044 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 1041826003045 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1041826003046 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1041826003047 homodimer interface [polypeptide binding]; other site 1041826003048 NADP binding site [chemical binding]; other site 1041826003049 substrate binding site [chemical binding]; other site 1041826003050 signal recognition particle protein; Provisional; Region: PRK10867 1041826003051 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1041826003052 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1041826003053 P loop; other site 1041826003054 GTP binding site [chemical binding]; other site 1041826003055 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1041826003056 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1041826003057 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826003058 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1041826003059 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1041826003060 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826003061 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1041826003062 Part of AAA domain; Region: AAA_19; pfam13245 1041826003063 Family description; Region: UvrD_C_2; pfam13538 1041826003064 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1041826003065 active site 1041826003066 dimerization interface [polypeptide binding]; other site 1041826003067 putative hydrolase; Provisional; Region: PRK02113 1041826003068 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1041826003069 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826003070 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1041826003071 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1041826003072 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826003073 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1041826003074 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1041826003075 Phosphate transporter family; Region: PHO4; pfam01384 1041826003076 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1041826003077 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1041826003078 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1041826003079 Zn binding site [ion binding]; other site 1041826003080 DoxX; Region: DoxX; pfam07681 1041826003081 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1041826003082 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041826003083 anthranilate synthase component I; Provisional; Region: PRK13569 1041826003084 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1041826003085 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1041826003086 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1041826003087 Ligand Binding Site [chemical binding]; other site 1041826003088 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1041826003089 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1041826003090 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1041826003091 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1041826003092 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826003093 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826003094 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1041826003095 ligand binding site [chemical binding]; other site 1041826003096 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1041826003097 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1041826003098 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1041826003099 homodimer interface [polypeptide binding]; other site 1041826003100 metal binding site [ion binding]; metal-binding site 1041826003101 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1041826003102 homodimer interface [polypeptide binding]; other site 1041826003103 active site 1041826003104 putative chemical substrate binding site [chemical binding]; other site 1041826003105 metal binding site [ion binding]; metal-binding site 1041826003106 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1041826003107 active site 1041826003108 catalytic residues [active] 1041826003109 metal binding site [ion binding]; metal-binding site 1041826003110 malate:quinone oxidoreductase; Validated; Region: PRK05257 1041826003111 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1041826003112 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1041826003113 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1041826003114 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1041826003115 trimer interface [polypeptide binding]; other site 1041826003116 active site 1041826003117 substrate binding site [chemical binding]; other site 1041826003118 CoA binding site [chemical binding]; other site 1041826003119 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1041826003120 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826003121 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826003122 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1041826003123 putative metal binding site; other site 1041826003124 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 1041826003125 putative active site [active] 1041826003126 putative catalytic site [active] 1041826003127 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826003128 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1041826003129 Ligand binding site; other site 1041826003130 Putative Catalytic site; other site 1041826003131 DXD motif; other site 1041826003132 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1041826003133 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1041826003134 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1041826003135 dimer interface [polypeptide binding]; other site 1041826003136 active site 1041826003137 CoA binding pocket [chemical binding]; other site 1041826003138 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1041826003139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826003140 Walker A/P-loop; other site 1041826003141 ATP binding site [chemical binding]; other site 1041826003142 Q-loop/lid; other site 1041826003143 ABC transporter signature motif; other site 1041826003144 Walker B; other site 1041826003145 D-loop; other site 1041826003146 H-loop/switch region; other site 1041826003147 Helix-turn-helix domain; Region: HTH_18; pfam12833 1041826003148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041826003149 ribonuclease G; Provisional; Region: PRK11712 1041826003150 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826003151 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826003152 ligand binding site [chemical binding]; other site 1041826003153 heat shock protein 90; Provisional; Region: PRK05218 1041826003154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826003155 ATP binding site [chemical binding]; other site 1041826003156 Mg2+ binding site [ion binding]; other site 1041826003157 G-X-G motif; other site 1041826003158 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1041826003159 DNA-binding site [nucleotide binding]; DNA binding site 1041826003160 RNA-binding motif; other site 1041826003161 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041826003162 RNA binding site [nucleotide binding]; other site 1041826003163 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1041826003164 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826003165 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826003166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826003167 binding surface 1041826003168 TPR motif; other site 1041826003169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826003170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826003171 binding surface 1041826003172 TPR motif; other site 1041826003173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826003174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826003175 binding surface 1041826003176 TPR motif; other site 1041826003177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826003178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826003179 dimer interface [polypeptide binding]; other site 1041826003180 phosphorylation site [posttranslational modification] 1041826003181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826003182 ATP binding site [chemical binding]; other site 1041826003183 Mg2+ binding site [ion binding]; other site 1041826003184 G-X-G motif; other site 1041826003185 Response regulator receiver domain; Region: Response_reg; pfam00072 1041826003186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826003187 active site 1041826003188 phosphorylation site [posttranslational modification] 1041826003189 intermolecular recognition site; other site 1041826003190 dimerization interface [polypeptide binding]; other site 1041826003191 Predicted membrane protein [Function unknown]; Region: COG4325 1041826003192 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1041826003193 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1041826003194 FAD binding domain; Region: FAD_binding_4; pfam01565 1041826003195 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1041826003196 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 1041826003197 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826003198 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1041826003199 ligand binding site [chemical binding]; other site 1041826003200 flexible hinge region; other site 1041826003201 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1041826003202 non-specific DNA interactions [nucleotide binding]; other site 1041826003203 DNA binding site [nucleotide binding] 1041826003204 sequence specific DNA binding site [nucleotide binding]; other site 1041826003205 putative cAMP binding site [chemical binding]; other site 1041826003206 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1041826003207 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1041826003208 Walker A; other site 1041826003209 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1041826003210 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1041826003211 multidrug efflux protein; Reviewed; Region: PRK01766 1041826003212 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1041826003213 cation binding site [ion binding]; other site 1041826003214 von Willebrand factor; Region: vWF_A; pfam12450 1041826003215 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1041826003216 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1041826003217 metal ion-dependent adhesion site (MIDAS); other site 1041826003218 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1041826003219 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1041826003220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826003221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826003222 ABC transporter; Region: ABC_tran_2; pfam12848 1041826003223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826003224 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1041826003225 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1041826003226 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1041826003227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826003228 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826003229 Peptidase family M13; Region: Peptidase_M13_N; pfam05649 1041826003230 Response regulator receiver domain; Region: Response_reg; pfam00072 1041826003231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826003232 active site 1041826003233 phosphorylation site [posttranslational modification] 1041826003234 intermolecular recognition site; other site 1041826003235 dimerization interface [polypeptide binding]; other site 1041826003236 PglZ domain; Region: PglZ; pfam08665 1041826003237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826003238 Fic family protein [Function unknown]; Region: COG3177 1041826003239 Fic/DOC family; Region: Fic; pfam02661 1041826003240 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1041826003241 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1041826003242 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1041826003243 G1 box; other site 1041826003244 GTP/Mg2+ binding site [chemical binding]; other site 1041826003245 Switch I region; other site 1041826003246 G2 box; other site 1041826003247 Switch II region; other site 1041826003248 G3 box; other site 1041826003249 G4 box; other site 1041826003250 G5 box; other site 1041826003251 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1041826003252 Bacterial SH3 domain; Region: SH3_3; cl17532 1041826003253 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1041826003254 NlpC/P60 family; Region: NLPC_P60; pfam00877 1041826003255 acetyl-CoA C-acetyltransferase; Region: PLN02644 1041826003256 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1041826003257 dimer interface [polypeptide binding]; other site 1041826003258 active site 1041826003259 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1041826003260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041826003261 non-specific DNA binding site [nucleotide binding]; other site 1041826003262 salt bridge; other site 1041826003263 sequence-specific DNA binding site [nucleotide binding]; other site 1041826003264 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1041826003265 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1041826003266 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1041826003267 intersubunit interface [polypeptide binding]; other site 1041826003268 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1041826003269 active site 1041826003270 dimer interface [polypeptide binding]; other site 1041826003271 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826003272 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826003273 ligand binding site [chemical binding]; other site 1041826003274 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1041826003275 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1041826003276 RF-1 domain; Region: RF-1; pfam00472 1041826003277 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1041826003278 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041826003279 active site 1041826003280 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041826003281 active site 1041826003282 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1041826003283 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1041826003284 active site 1041826003285 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1041826003286 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1041826003287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826003288 Walker A motif; other site 1041826003289 ATP binding site [chemical binding]; other site 1041826003290 Walker B motif; other site 1041826003291 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1041826003292 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1041826003293 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1041826003294 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1041826003295 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1041826003296 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 1041826003297 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1041826003298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1041826003299 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1041826003300 FAD binding site [chemical binding]; other site 1041826003301 homotetramer interface [polypeptide binding]; other site 1041826003302 substrate binding pocket [chemical binding]; other site 1041826003303 catalytic base [active] 1041826003304 Protein of unknown function (DUF465); Region: DUF465; cl01070 1041826003305 Family description; Region: DsbD_2; pfam13386 1041826003306 FixH; Region: FixH; pfam05751 1041826003307 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1041826003308 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1041826003309 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1041826003310 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1041826003311 Cytochrome c; Region: Cytochrom_C; pfam00034 1041826003312 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1041826003313 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 1041826003314 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1041826003315 Low-spin heme binding site [chemical binding]; other site 1041826003316 Putative water exit pathway; other site 1041826003317 Binuclear center (active site) [active] 1041826003318 Putative proton exit pathway; other site 1041826003319 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1041826003320 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1041826003321 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1041826003322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1041826003323 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1041826003324 metal-binding site [ion binding] 1041826003325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1041826003326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041826003327 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826003328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826003329 ligand binding site [chemical binding]; other site 1041826003330 flexible hinge region; other site 1041826003331 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1041826003332 putative switch regulator; other site 1041826003333 non-specific DNA interactions [nucleotide binding]; other site 1041826003334 DNA binding site [nucleotide binding] 1041826003335 sequence specific DNA binding site [nucleotide binding]; other site 1041826003336 putative cAMP binding site [chemical binding]; other site 1041826003337 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1041826003338 Asp-box motif; other site 1041826003339 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826003340 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1041826003341 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1041826003342 dimerization interface [polypeptide binding]; other site 1041826003343 ATP binding site [chemical binding]; other site 1041826003344 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1041826003345 dimerization interface [polypeptide binding]; other site 1041826003346 ATP binding site [chemical binding]; other site 1041826003347 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1041826003348 putative active site [active] 1041826003349 catalytic triad [active] 1041826003350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1041826003351 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1041826003352 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1041826003353 active site 1041826003354 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826003355 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826003356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826003357 TPR motif; other site 1041826003358 binding surface 1041826003359 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1041826003360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826003361 binding surface 1041826003362 TPR motif; other site 1041826003363 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1041826003364 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1041826003365 active site 1041826003366 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1041826003367 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1041826003368 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1041826003369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1041826003370 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041826003371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041826003372 Walker A/P-loop; other site 1041826003373 ATP binding site [chemical binding]; other site 1041826003374 Q-loop/lid; other site 1041826003375 ABC transporter signature motif; other site 1041826003376 Walker B; other site 1041826003377 D-loop; other site 1041826003378 H-loop/switch region; other site 1041826003379 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 1041826003380 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1041826003381 active site 1041826003382 dimer interfaces [polypeptide binding]; other site 1041826003383 catalytic residues [active] 1041826003384 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1041826003385 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1041826003386 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 1041826003387 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1041826003388 6-phosphofructokinase; Provisional; Region: PRK03202 1041826003389 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1041826003390 active site 1041826003391 ADP/pyrophosphate binding site [chemical binding]; other site 1041826003392 dimerization interface [polypeptide binding]; other site 1041826003393 allosteric effector site; other site 1041826003394 fructose-1,6-bisphosphate binding site; other site 1041826003395 Family of unknown function (DUF490); Region: DUF490; pfam04357 1041826003396 UGMP family protein; Validated; Region: PRK09604 1041826003397 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1041826003398 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1041826003399 RNA methyltransferase, RsmE family; Region: TIGR00046 1041826003400 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1041826003401 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041826003402 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1041826003403 active site 1041826003404 Predicted metalloprotease [General function prediction only]; Region: COG2321 1041826003405 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1041826003406 PAS fold; Region: PAS_3; pfam08447 1041826003407 PAS domain S-box; Region: sensory_box; TIGR00229 1041826003408 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1041826003409 putative active site [active] 1041826003410 heme pocket [chemical binding]; other site 1041826003411 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1041826003412 GAF domain; Region: GAF; pfam01590 1041826003413 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1041826003414 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1041826003415 PAS fold; Region: PAS_3; pfam08447 1041826003416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1041826003417 putative active site [active] 1041826003418 heme pocket [chemical binding]; other site 1041826003419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826003420 dimer interface [polypeptide binding]; other site 1041826003421 phosphorylation site [posttranslational modification] 1041826003422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826003423 ATP binding site [chemical binding]; other site 1041826003424 Mg2+ binding site [ion binding]; other site 1041826003425 G-X-G motif; other site 1041826003426 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1041826003427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826003428 active site 1041826003429 phosphorylation site [posttranslational modification] 1041826003430 intermolecular recognition site; other site 1041826003431 dimerization interface [polypeptide binding]; other site 1041826003432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826003433 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1041826003434 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1041826003435 active site 1041826003436 dinuclear metal binding site [ion binding]; other site 1041826003437 dimerization interface [polypeptide binding]; other site 1041826003438 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1041826003439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1041826003440 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1041826003441 ATP binding site [chemical binding]; other site 1041826003442 Mg++ binding site [ion binding]; other site 1041826003443 motif III; other site 1041826003444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826003445 nucleotide binding region [chemical binding]; other site 1041826003446 ATP-binding site [chemical binding]; other site 1041826003447 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1041826003448 putative active site [active] 1041826003449 putative metal binding site [ion binding]; other site 1041826003450 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1041826003451 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1041826003452 AMP binding site [chemical binding]; other site 1041826003453 active site 1041826003454 acyl-activating enzyme (AAE) consensus motif; other site 1041826003455 CoA binding site [chemical binding]; other site 1041826003456 CAAX protease self-immunity; Region: Abi; pfam02517 1041826003457 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1041826003458 ArsC family; Region: ArsC; pfam03960 1041826003459 catalytic residues [active] 1041826003460 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826003461 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826003462 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826003463 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1041826003464 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1041826003465 oligomer interface [polypeptide binding]; other site 1041826003466 metal binding site [ion binding]; metal-binding site 1041826003467 metal binding site [ion binding]; metal-binding site 1041826003468 Cl binding site [ion binding]; other site 1041826003469 aspartate ring; other site 1041826003470 basic sphincter; other site 1041826003471 putative hydrophobic gate; other site 1041826003472 periplasmic entrance; other site 1041826003473 imidazolonepropionase; Validated; Region: PRK09356 1041826003474 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1041826003475 active site 1041826003476 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 1041826003477 metal binding site [ion binding]; metal-binding site 1041826003478 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1041826003479 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1041826003480 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1041826003481 putative ATP binding site [chemical binding]; other site 1041826003482 putative substrate interface [chemical binding]; other site 1041826003483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041826003484 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 1041826003485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826003486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1041826003487 putative substrate translocation pore; other site 1041826003488 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1041826003489 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1041826003490 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1041826003491 dimer interface [polypeptide binding]; other site 1041826003492 putative tRNA-binding site [nucleotide binding]; other site 1041826003493 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1041826003494 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1041826003495 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1041826003496 Protein export membrane protein; Region: SecD_SecF; pfam02355 1041826003497 malate dehydrogenase; Reviewed; Region: PRK06223 1041826003498 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1041826003499 NAD(P) binding site [chemical binding]; other site 1041826003500 dimer interface [polypeptide binding]; other site 1041826003501 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041826003502 substrate binding site [chemical binding]; other site 1041826003503 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1041826003504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826003505 ATP binding site [chemical binding]; other site 1041826003506 Mg2+ binding site [ion binding]; other site 1041826003507 G-X-G motif; other site 1041826003508 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1041826003509 anchoring element; other site 1041826003510 dimer interface [polypeptide binding]; other site 1041826003511 ATP binding site [chemical binding]; other site 1041826003512 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1041826003513 active site 1041826003514 putative metal-binding site [ion binding]; other site 1041826003515 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1041826003516 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1041826003517 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1041826003518 active site 1041826003519 dimer interface [polypeptide binding]; other site 1041826003520 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1041826003521 Ligand Binding Site [chemical binding]; other site 1041826003522 Molecular Tunnel; other site 1041826003523 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1041826003524 nudix motif; other site 1041826003525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826003526 active site 1041826003527 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1041826003528 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1041826003529 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1041826003530 ATP binding site [chemical binding]; other site 1041826003531 Mg++ binding site [ion binding]; other site 1041826003532 motif III; other site 1041826003533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826003534 nucleotide binding region [chemical binding]; other site 1041826003535 ATP-binding site [chemical binding]; other site 1041826003536 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1041826003537 RNA binding site [nucleotide binding]; other site 1041826003538 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1041826003539 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1041826003540 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1041826003541 dimer interface [polypeptide binding]; other site 1041826003542 FMN binding site [chemical binding]; other site 1041826003543 Predicted transcriptional regulators [Transcription]; Region: COG1733 1041826003544 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1041826003545 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041826003546 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041826003547 Walker A/P-loop; other site 1041826003548 ATP binding site [chemical binding]; other site 1041826003549 Q-loop/lid; other site 1041826003550 ABC transporter signature motif; other site 1041826003551 Walker B; other site 1041826003552 D-loop; other site 1041826003553 H-loop/switch region; other site 1041826003554 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1041826003555 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1041826003556 FtsX-like permease family; Region: FtsX; pfam02687 1041826003557 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1041826003558 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826003559 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1041826003560 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1041826003561 active site 1041826003562 (T/H)XGH motif; other site 1041826003563 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1041826003564 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1041826003565 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041826003566 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1041826003567 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1041826003568 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1041826003569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041826003570 RNA binding surface [nucleotide binding]; other site 1041826003571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1041826003572 active site 1041826003573 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 1041826003574 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041826003575 metal binding site [ion binding]; metal-binding site 1041826003576 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1041826003577 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1041826003578 DinB superfamily; Region: DinB_2; pfam12867 1041826003579 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1041826003580 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1041826003581 putative active site [active] 1041826003582 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1041826003583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826003584 S-adenosylmethionine binding site [chemical binding]; other site 1041826003585 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1041826003586 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1041826003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826003588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1041826003589 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1041826003590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826003591 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1041826003592 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826003593 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826003594 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1041826003595 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826003596 active site 1041826003597 DNA binding site [nucleotide binding] 1041826003598 Int/Topo IB signature motif; other site 1041826003599 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 1041826003600 Predicted transcriptional regulator [Transcription]; Region: COG2378 1041826003601 HTH domain; Region: HTH_11; pfam08279 1041826003602 WYL domain; Region: WYL; pfam13280 1041826003603 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1041826003604 homotrimer interaction site [polypeptide binding]; other site 1041826003605 putative active site [active] 1041826003606 Transposase domain (DUF772); Region: DUF772; pfam05598 1041826003607 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1041826003608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041826003609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826003610 active site 1041826003611 phosphorylation site [posttranslational modification] 1041826003612 intermolecular recognition site; other site 1041826003613 dimerization interface [polypeptide binding]; other site 1041826003614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041826003615 DNA binding site [nucleotide binding] 1041826003616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826003617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826003618 dimer interface [polypeptide binding]; other site 1041826003619 phosphorylation site [posttranslational modification] 1041826003620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826003621 ATP binding site [chemical binding]; other site 1041826003622 Mg2+ binding site [ion binding]; other site 1041826003623 G-X-G motif; other site 1041826003624 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1041826003625 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1041826003626 CoA-binding site [chemical binding]; other site 1041826003627 ATP-binding [chemical binding]; other site 1041826003628 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1041826003629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826003630 active site 1041826003631 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 1041826003632 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826003633 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1041826003634 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1041826003635 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1041826003636 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1041826003637 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1041826003638 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1041826003639 Walker A/P-loop; other site 1041826003640 ATP binding site [chemical binding]; other site 1041826003641 Q-loop/lid; other site 1041826003642 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1041826003643 ABC transporter signature motif; other site 1041826003644 Walker B; other site 1041826003645 D-loop; other site 1041826003646 H-loop/switch region; other site 1041826003647 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1041826003648 Flavoprotein; Region: Flavoprotein; pfam02441 1041826003649 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1041826003650 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 1041826003651 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1041826003652 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1041826003653 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1041826003654 dimer interface [polypeptide binding]; other site 1041826003655 active site 1041826003656 catalytic residue [active] 1041826003657 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1041826003658 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1041826003659 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1041826003660 active site 1041826003661 metal binding site [ion binding]; metal-binding site 1041826003662 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1041826003663 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1041826003664 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1041826003665 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1041826003666 Beta-lactamase; Region: Beta-lactamase; cl17358 1041826003667 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1041826003668 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1041826003669 Cysteine-rich domain; Region: CCG; pfam02754 1041826003670 Cysteine-rich domain; Region: CCG; pfam02754 1041826003671 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1041826003672 4Fe-4S binding domain; Region: Fer4; cl02805 1041826003673 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1041826003674 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1041826003675 mce related protein; Region: MCE; pfam02470 1041826003676 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1041826003677 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1041826003678 active site 1041826003679 metal binding site [ion binding]; metal-binding site 1041826003680 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1041826003681 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1041826003682 homotrimer interaction site [polypeptide binding]; other site 1041826003683 putative active site [active] 1041826003684 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1041826003685 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1041826003686 nucleotide binding site [chemical binding]; other site 1041826003687 NEF interaction site [polypeptide binding]; other site 1041826003688 SBD interface [polypeptide binding]; other site 1041826003689 Predicted metalloprotease [General function prediction only]; Region: COG2321 1041826003690 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1041826003691 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1041826003692 EamA-like transporter family; Region: EamA; pfam00892 1041826003693 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1041826003694 glucose/galactose transporter; Region: gluP; TIGR01272 1041826003695 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1041826003696 Smr domain; Region: Smr; pfam01713 1041826003697 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1041826003698 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 1041826003699 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1041826003700 inhibitor-cofactor binding pocket; inhibition site 1041826003701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826003702 catalytic residue [active] 1041826003703 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1041826003704 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1041826003705 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1041826003706 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826003707 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826003708 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826003709 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826003710 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1041826003711 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1041826003712 TRAM domain; Region: TRAM; cl01282 1041826003713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826003714 S-adenosylmethionine binding site [chemical binding]; other site 1041826003715 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1041826003716 S1 domain; Region: S1_2; pfam13509 1041826003717 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041826003718 RNA binding site [nucleotide binding]; other site 1041826003719 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 1041826003720 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1041826003721 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1041826003722 dimer interface [polypeptide binding]; other site 1041826003723 tetramer interface [polypeptide binding]; other site 1041826003724 PYR/PP interface [polypeptide binding]; other site 1041826003725 TPP binding site [chemical binding]; other site 1041826003726 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1041826003727 TPP-binding site; other site 1041826003728 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1041826003729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826003730 Coenzyme A binding pocket [chemical binding]; other site 1041826003731 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1041826003732 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1041826003733 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 1041826003734 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1041826003735 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1041826003736 YhhN-like protein; Region: YhhN; pfam07947 1041826003737 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1041826003738 active site 1041826003739 multimer interface [polypeptide binding]; other site 1041826003740 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1041826003741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1041826003742 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1041826003743 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1041826003744 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 1041826003745 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826003746 B12 binding domain; Region: B12-binding; pfam02310 1041826003747 B12 binding site [chemical binding]; other site 1041826003748 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1041826003749 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1041826003750 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1041826003751 G1 box; other site 1041826003752 putative GEF interaction site [polypeptide binding]; other site 1041826003753 GTP/Mg2+ binding site [chemical binding]; other site 1041826003754 Switch I region; other site 1041826003755 G2 box; other site 1041826003756 G3 box; other site 1041826003757 Switch II region; other site 1041826003758 G4 box; other site 1041826003759 G5 box; other site 1041826003760 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1041826003761 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1041826003762 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1041826003763 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1041826003764 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1041826003765 dimer interface [polypeptide binding]; other site 1041826003766 motif 1; other site 1041826003767 active site 1041826003768 motif 2; other site 1041826003769 motif 3; other site 1041826003770 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1041826003771 anticodon binding site; other site 1041826003772 zinc-binding site [ion binding]; other site 1041826003773 DNA translocase FtsK; Provisional; Region: PRK10263 1041826003774 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1041826003775 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1041826003776 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1041826003777 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826003778 FeS/SAM binding site; other site 1041826003779 MULE transposase domain; Region: MULE; pfam10551 1041826003780 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1041826003781 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1041826003782 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1041826003783 DNA photolyase; Region: DNA_photolyase; pfam00875 1041826003784 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1041826003785 putative hydrophobic ligand binding site [chemical binding]; other site 1041826003786 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1041826003787 beta-carotene hydroxylase; Region: PLN02601 1041826003788 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1041826003789 active site lid residues [active] 1041826003790 substrate binding pocket [chemical binding]; other site 1041826003791 catalytic residues [active] 1041826003792 substrate-Mg2+ binding site; other site 1041826003793 aspartate-rich region 1; other site 1041826003794 aspartate-rich region 2; other site 1041826003795 phytoene desaturase; Region: crtI_fam; TIGR02734 1041826003796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1041826003797 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1041826003798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826003799 NAD(P) binding site [chemical binding]; other site 1041826003800 active site 1041826003801 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1041826003802 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1041826003803 classical (c) SDRs; Region: SDR_c; cd05233 1041826003804 NAD(P) binding site [chemical binding]; other site 1041826003805 active site 1041826003806 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1041826003807 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1041826003808 Beta-lactamase; Region: Beta-lactamase; pfam00144 1041826003809 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1041826003810 catalytic residues [active] 1041826003811 dimer interface [polypeptide binding]; other site 1041826003812 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1041826003813 catalytic residues [active] 1041826003814 dimer interface [polypeptide binding]; other site 1041826003815 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1041826003816 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1041826003817 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1041826003818 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1041826003819 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1041826003820 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1041826003821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041826003822 active site 1041826003823 motif I; other site 1041826003824 motif II; other site 1041826003825 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1041826003826 UbiA prenyltransferase family; Region: UbiA; pfam01040 1041826003827 Maf-like protein; Region: Maf; pfam02545 1041826003828 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1041826003829 active site 1041826003830 dimer interface [polypeptide binding]; other site 1041826003831 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1041826003832 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1041826003833 dimerization interface 3.5A [polypeptide binding]; other site 1041826003834 active site 1041826003835 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041826003836 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041826003837 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1041826003838 Walker A/P-loop; other site 1041826003839 ATP binding site [chemical binding]; other site 1041826003840 Q-loop/lid; other site 1041826003841 ABC transporter signature motif; other site 1041826003842 Walker B; other site 1041826003843 D-loop; other site 1041826003844 H-loop/switch region; other site 1041826003845 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1041826003846 active site 1041826003847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826003848 binding surface 1041826003849 TPR repeat; Region: TPR_11; pfam13414 1041826003850 TPR motif; other site 1041826003851 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1041826003852 dihydropteroate synthase; Region: DHPS; TIGR01496 1041826003853 substrate binding pocket [chemical binding]; other site 1041826003854 dimer interface [polypeptide binding]; other site 1041826003855 inhibitor binding site; inhibition site 1041826003856 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 1041826003857 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 1041826003858 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1041826003859 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826003860 catalytic residues [active] 1041826003861 triosephosphate isomerase; Provisional; Region: PRK14567 1041826003862 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1041826003863 substrate binding site [chemical binding]; other site 1041826003864 dimer interface [polypeptide binding]; other site 1041826003865 catalytic triad [active] 1041826003866 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1041826003867 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1041826003868 ATP-binding site [chemical binding]; other site 1041826003869 Sugar specificity; other site 1041826003870 Pyrimidine base specificity; other site 1041826003871 Septum formation initiator; Region: DivIC; pfam04977 1041826003872 Secretory lipase; Region: LIP; pfam03583 1041826003873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041826003874 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1041826003875 heterodimer interface [polypeptide binding]; other site 1041826003876 substrate interaction site [chemical binding]; other site 1041826003877 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1041826003878 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1041826003879 active site 1041826003880 substrate binding site [chemical binding]; other site 1041826003881 coenzyme B12 binding site [chemical binding]; other site 1041826003882 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1041826003883 B12 binding site [chemical binding]; other site 1041826003884 cobalt ligand [ion binding]; other site 1041826003885 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1041826003886 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1041826003887 cofactor binding site; other site 1041826003888 DNA binding site [nucleotide binding] 1041826003889 substrate interaction site [chemical binding]; other site 1041826003890 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1041826003891 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1041826003892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826003893 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1041826003894 ATP binding site [chemical binding]; other site 1041826003895 Mg2+ binding site [ion binding]; other site 1041826003896 G-X-G motif; other site 1041826003897 HNH endonuclease; Region: HNH_2; pfam13391 1041826003898 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1041826003899 active site 1041826003900 catalytic residues [active] 1041826003901 Acylphosphatase; Region: Acylphosphatase; cl00551 1041826003902 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1041826003903 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1041826003904 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 1041826003905 hypothetical protein; Reviewed; Region: PRK09588 1041826003906 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1041826003907 amino acid transporter; Region: 2A0306; TIGR00909 1041826003908 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1041826003909 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1041826003910 active site 1041826003911 catalytic residues [active] 1041826003912 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1041826003913 SmpB-tmRNA interface; other site 1041826003914 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1041826003915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826003916 S-adenosylmethionine binding site [chemical binding]; other site 1041826003917 quinolinate synthetase; Provisional; Region: PRK09375 1041826003918 L-aspartate oxidase; Provisional; Region: PRK09077 1041826003919 L-aspartate oxidase; Provisional; Region: PRK06175 1041826003920 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1041826003921 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1041826003922 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1041826003923 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1041826003924 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1041826003925 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1041826003926 cofactor binding site; other site 1041826003927 DNA binding site [nucleotide binding] 1041826003928 substrate interaction site [chemical binding]; other site 1041826003929 NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521 1041826003930 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1041826003931 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1041826003932 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1041826003933 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1041826003934 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1041826003935 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1041826003936 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1041826003937 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1041826003938 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1041826003939 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041826003940 catalytic residue [active] 1041826003941 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1041826003942 active site 1041826003943 catalytic site [active] 1041826003944 substrate binding site [chemical binding]; other site 1041826003945 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1041826003946 GIY-YIG motif/motif A; other site 1041826003947 active site 1041826003948 catalytic site [active] 1041826003949 putative DNA binding site [nucleotide binding]; other site 1041826003950 metal binding site [ion binding]; metal-binding site 1041826003951 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1041826003952 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1041826003953 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1041826003954 active site 1041826003955 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 1041826003956 active site 2 [active] 1041826003957 active site 1 [active] 1041826003958 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 1041826003959 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1041826003960 CAP-like domain; other site 1041826003961 active site 1041826003962 primary dimer interface [polypeptide binding]; other site 1041826003963 GxxExxY protein; Region: GxxExxY; TIGR04256 1041826003964 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1041826003965 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1041826003966 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1041826003967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826003968 ATP binding site [chemical binding]; other site 1041826003969 Mg2+ binding site [ion binding]; other site 1041826003970 G-X-G motif; other site 1041826003971 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1041826003972 anchoring element; other site 1041826003973 dimer interface [polypeptide binding]; other site 1041826003974 ATP binding site [chemical binding]; other site 1041826003975 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1041826003976 active site 1041826003977 putative metal-binding site [ion binding]; other site 1041826003978 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1041826003979 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826003980 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1041826003981 N-terminal plug; other site 1041826003982 ligand-binding site [chemical binding]; other site 1041826003983 GTP-binding protein YchF; Reviewed; Region: PRK09601 1041826003984 YchF GTPase; Region: YchF; cd01900 1041826003985 G1 box; other site 1041826003986 GTP/Mg2+ binding site [chemical binding]; other site 1041826003987 Switch I region; other site 1041826003988 G2 box; other site 1041826003989 Switch II region; other site 1041826003990 G3 box; other site 1041826003991 G4 box; other site 1041826003992 G5 box; other site 1041826003993 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1041826003994 potential frameshift: common BLAST hit: gi|326796984|ref|YP_004314804.1| transposase mutator type 1041826003995 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 1041826003996 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1041826003997 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1041826003998 oligomer interface [polypeptide binding]; other site 1041826003999 active site 1041826004000 metal binding site [ion binding]; metal-binding site 1041826004001 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 1041826004002 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004003 Putative cyclase; Region: Cyclase; pfam04199 1041826004004 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1041826004005 ATP binding site [chemical binding]; other site 1041826004006 active site 1041826004007 substrate binding site [chemical binding]; other site 1041826004008 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1041826004009 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1041826004010 heme-binding site [chemical binding]; other site 1041826004011 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1041826004012 FAD binding pocket [chemical binding]; other site 1041826004013 FAD binding motif [chemical binding]; other site 1041826004014 phosphate binding motif [ion binding]; other site 1041826004015 beta-alpha-beta structure motif; other site 1041826004016 NAD binding pocket [chemical binding]; other site 1041826004017 Transcriptional regulator; Region: Rrf2; cl17282 1041826004018 Rrf2 family protein; Region: rrf2_super; TIGR00738 1041826004019 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1041826004020 putative substrate binding pocket [chemical binding]; other site 1041826004021 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1041826004022 PhoH-like protein; Region: PhoH; pfam02562 1041826004023 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1041826004024 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1041826004025 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1041826004026 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1041826004027 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 1041826004028 DNA polymerase III subunit beta; Validated; Region: PRK05643 1041826004029 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1041826004030 putative DNA binding surface [nucleotide binding]; other site 1041826004031 dimer interface [polypeptide binding]; other site 1041826004032 beta-clamp/clamp loader binding surface; other site 1041826004033 beta-clamp/translesion DNA polymerase binding surface; other site 1041826004034 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1041826004035 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1041826004036 ATP binding site [chemical binding]; other site 1041826004037 Mg++ binding site [ion binding]; other site 1041826004038 motif III; other site 1041826004039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826004040 nucleotide binding region [chemical binding]; other site 1041826004041 ATP-binding site [chemical binding]; other site 1041826004042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826004043 binding surface 1041826004044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826004045 TPR motif; other site 1041826004046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826004047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826004048 dimer interface [polypeptide binding]; other site 1041826004049 phosphorylation site [posttranslational modification] 1041826004050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004051 ATP binding site [chemical binding]; other site 1041826004052 Mg2+ binding site [ion binding]; other site 1041826004053 G-X-G motif; other site 1041826004054 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1041826004055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826004056 active site 1041826004057 phosphorylation site [posttranslational modification] 1041826004058 intermolecular recognition site; other site 1041826004059 dimerization interface [polypeptide binding]; other site 1041826004060 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1041826004061 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1041826004062 dihydroorotase; Validated; Region: pyrC; PRK09357 1041826004063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041826004064 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1041826004065 active site 1041826004066 Predicted esterase [General function prediction only]; Region: COG0400 1041826004067 putative hydrolase; Provisional; Region: PRK11460 1041826004068 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1041826004069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041826004070 RNA binding surface [nucleotide binding]; other site 1041826004071 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1041826004072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826004073 active site 1041826004074 shikimate kinase; Reviewed; Region: aroK; PRK00131 1041826004075 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1041826004076 ADP binding site [chemical binding]; other site 1041826004077 magnesium binding site [ion binding]; other site 1041826004078 putative shikimate binding site; other site 1041826004079 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1041826004080 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826004081 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1041826004082 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1041826004083 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826004084 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1041826004085 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 1041826004086 MULE transposase domain; Region: MULE; pfam10551 1041826004087 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1041826004088 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826004089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826004090 S-adenosylmethionine binding site [chemical binding]; other site 1041826004091 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1041826004092 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1041826004093 DNA binding site [nucleotide binding] 1041826004094 active site 1041826004095 Domain of unknown function DUF59; Region: DUF59; pfam01883 1041826004096 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1041826004097 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1041826004098 Walker A motif; other site 1041826004099 NifU-like domain; Region: NifU; cl00484 1041826004100 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1041826004101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041826004102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041826004103 EamA-like transporter family; Region: EamA; pfam00892 1041826004104 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1041826004105 EamA-like transporter family; Region: EamA; pfam00892 1041826004106 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1041826004107 metal-binding site [ion binding] 1041826004108 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 1041826004109 active site 1041826004110 catalytic triad [active] 1041826004111 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1041826004112 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 1041826004113 heterodimerization interface [polypeptide binding]; other site 1041826004114 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1041826004115 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004116 ribonuclease P; Reviewed; Region: rnpA; PRK01903 1041826004117 Ribonuclease P; Region: Ribonuclease_P; cl00457 1041826004118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1041826004119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826004120 active site 1041826004121 phosphorylation site [posttranslational modification] 1041826004122 intermolecular recognition site; other site 1041826004123 dimerization interface [polypeptide binding]; other site 1041826004124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826004125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1041826004126 Histidine kinase; Region: HisKA_3; pfam07730 1041826004127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004128 ATP binding site [chemical binding]; other site 1041826004129 Mg2+ binding site [ion binding]; other site 1041826004130 G-X-G motif; other site 1041826004131 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1041826004132 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1041826004133 active site 1041826004134 metal binding site [ion binding]; metal-binding site 1041826004135 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 1041826004136 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1041826004137 PhnA protein; Region: PhnA; pfam03831 1041826004138 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826004139 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826004140 conserved hypothetical protein; Region: MJ1255; TIGR00661 1041826004141 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1041826004142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1041826004143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826004144 dimer interface [polypeptide binding]; other site 1041826004145 phosphorylation site [posttranslational modification] 1041826004146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004147 ATP binding site [chemical binding]; other site 1041826004148 Mg2+ binding site [ion binding]; other site 1041826004149 G-X-G motif; other site 1041826004150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1041826004151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826004152 active site 1041826004153 phosphorylation site [posttranslational modification] 1041826004154 intermolecular recognition site; other site 1041826004155 dimerization interface [polypeptide binding]; other site 1041826004156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1041826004157 DNA binding site [nucleotide binding] 1041826004158 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826004159 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1041826004160 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826004161 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004162 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004163 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004164 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 1041826004165 active site 1041826004166 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1041826004167 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1041826004168 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1041826004169 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1041826004170 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1041826004171 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1041826004172 carboxyltransferase (CT) interaction site; other site 1041826004173 biotinylation site [posttranslational modification]; other site 1041826004174 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1041826004175 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1041826004176 dimer interface [polypeptide binding]; other site 1041826004177 active site 1041826004178 CoA binding pocket [chemical binding]; other site 1041826004179 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1041826004180 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1041826004181 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1041826004182 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1041826004183 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1041826004184 Lumazine binding domain; Region: Lum_binding; pfam00677 1041826004185 Lumazine binding domain; Region: Lum_binding; pfam00677 1041826004186 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1041826004187 core domain interface [polypeptide binding]; other site 1041826004188 delta subunit interface [polypeptide binding]; other site 1041826004189 epsilon subunit interface [polypeptide binding]; other site 1041826004190 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1041826004191 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1041826004192 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1041826004193 beta subunit interaction interface [polypeptide binding]; other site 1041826004194 Walker A motif; other site 1041826004195 ATP binding site [chemical binding]; other site 1041826004196 Walker B motif; other site 1041826004197 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1041826004198 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1041826004199 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1041826004200 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471 1041826004201 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1041826004202 ATP synthase A chain; Region: ATP-synt_A; cl00413 1041826004203 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1041826004204 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1041826004205 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826004206 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1041826004207 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004208 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1041826004209 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1041826004210 FAD binding pocket [chemical binding]; other site 1041826004211 FAD binding motif [chemical binding]; other site 1041826004212 phosphate binding motif [ion binding]; other site 1041826004213 beta-alpha-beta structure motif; other site 1041826004214 NAD(p) ribose binding residues [chemical binding]; other site 1041826004215 NAD binding pocket [chemical binding]; other site 1041826004216 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1041826004217 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1041826004218 catalytic loop [active] 1041826004219 iron binding site [ion binding]; other site 1041826004220 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1041826004221 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1041826004222 putative active site [active] 1041826004223 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1041826004224 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 1041826004225 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826004226 active site 1041826004227 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1041826004228 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1041826004229 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1041826004230 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1041826004231 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1041826004232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1041826004233 acyl-activating enzyme (AAE) consensus motif; other site 1041826004234 active site 1041826004235 AMP binding site [chemical binding]; other site 1041826004236 CoA binding site [chemical binding]; other site 1041826004237 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826004238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041826004239 active site 1041826004240 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1041826004241 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1041826004242 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1041826004243 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1041826004244 NAD binding site [chemical binding]; other site 1041826004245 putative substrate binding site 2 [chemical binding]; other site 1041826004246 putative substrate binding site 1 [chemical binding]; other site 1041826004247 active site 1041826004248 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1041826004249 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1041826004250 NADP binding site [chemical binding]; other site 1041826004251 active site 1041826004252 putative substrate binding site [chemical binding]; other site 1041826004253 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1041826004254 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 1041826004255 substrate binding site [chemical binding]; other site 1041826004256 catalytic residues [active] 1041826004257 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1041826004258 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1041826004259 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1041826004260 active site 1041826004261 Zn binding site [ion binding]; other site 1041826004262 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1041826004263 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1041826004264 Cu(I) binding site [ion binding]; other site 1041826004265 Leucine rich repeat; Region: LRR_8; pfam13855 1041826004266 Leucine rich repeat; Region: LRR_8; pfam13855 1041826004267 fumarate hydratase; Provisional; Region: PRK15389 1041826004268 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1041826004269 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1041826004270 Peptidase family M1; Region: Peptidase_M1; pfam01433 1041826004271 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1041826004272 Zn binding site [ion binding]; other site 1041826004273 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004274 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1041826004275 RIP metalloprotease RseP; Region: TIGR00054 1041826004276 active site 1041826004277 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1041826004278 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1041826004279 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1041826004280 putative substrate binding region [chemical binding]; other site 1041826004281 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826004282 SnoaL-like domain; Region: SnoaL_3; pfam13474 1041826004283 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1041826004284 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 1041826004285 NAD binding site [chemical binding]; other site 1041826004286 homodimer interface [polypeptide binding]; other site 1041826004287 active site 1041826004288 putative substrate binding site [chemical binding]; other site 1041826004289 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1041826004290 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1041826004291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826004292 ATP binding site [chemical binding]; other site 1041826004293 putative Mg++ binding site [ion binding]; other site 1041826004294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826004295 nucleotide binding region [chemical binding]; other site 1041826004296 ATP-binding site [chemical binding]; other site 1041826004297 TRCF domain; Region: TRCF; pfam03461 1041826004298 Family description; Region: ACT_7; pfam13840 1041826004299 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1041826004300 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1041826004301 dimer interface [polypeptide binding]; other site 1041826004302 catalytic triad [active] 1041826004303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826004304 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826004305 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1041826004306 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1041826004307 active site 1041826004308 HIGH motif; other site 1041826004309 KMSKS motif; other site 1041826004310 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1041826004311 tRNA binding surface [nucleotide binding]; other site 1041826004312 anticodon binding site; other site 1041826004313 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1041826004314 dimer interface [polypeptide binding]; other site 1041826004315 putative tRNA-binding site [nucleotide binding]; other site 1041826004316 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1041826004317 Ferritin-like domain; Region: Ferritin; pfam00210 1041826004318 ferroxidase diiron center [ion binding]; other site 1041826004319 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1041826004320 Response regulator receiver domain; Region: Response_reg; pfam00072 1041826004321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826004322 active site 1041826004323 phosphorylation site [posttranslational modification] 1041826004324 intermolecular recognition site; other site 1041826004325 dimerization interface [polypeptide binding]; other site 1041826004326 Heme NO binding; Region: HNOB; pfam07700 1041826004327 Heme NO binding associated; Region: HNOBA; pfam07701 1041826004328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1041826004329 PAS domain; Region: PAS_9; pfam13426 1041826004330 putative active site [active] 1041826004331 heme pocket [chemical binding]; other site 1041826004332 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1041826004333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1041826004334 putative active site [active] 1041826004335 heme pocket [chemical binding]; other site 1041826004336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826004337 dimer interface [polypeptide binding]; other site 1041826004338 phosphorylation site [posttranslational modification] 1041826004339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004340 ATP binding site [chemical binding]; other site 1041826004341 Mg2+ binding site [ion binding]; other site 1041826004342 G-X-G motif; other site 1041826004343 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1041826004344 FIST N domain; Region: FIST; pfam08495 1041826004345 FIST C domain; Region: FIST_C; pfam10442 1041826004346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004347 ATP binding site [chemical binding]; other site 1041826004348 Mg2+ binding site [ion binding]; other site 1041826004349 G-X-G motif; other site 1041826004350 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1041826004351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826004352 active site 1041826004353 phosphorylation site [posttranslational modification] 1041826004354 intermolecular recognition site; other site 1041826004355 dimerization interface [polypeptide binding]; other site 1041826004356 LytTr DNA-binding domain; Region: LytTR; smart00850 1041826004357 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826004359 TPR motif; other site 1041826004360 binding surface 1041826004361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826004362 binding surface 1041826004363 TPR motif; other site 1041826004364 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041826004365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826004366 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041826004367 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1041826004368 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1041826004369 Predicted integral membrane protein [Function unknown]; Region: COG5617 1041826004370 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1041826004371 Response regulator receiver domain; Region: Response_reg; pfam00072 1041826004372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826004373 active site 1041826004374 phosphorylation site [posttranslational modification] 1041826004375 intermolecular recognition site; other site 1041826004376 dimerization interface [polypeptide binding]; other site 1041826004377 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 1041826004378 Ligand binding site; other site 1041826004379 Ligand binding site; other site 1041826004380 Ligand binding site; other site 1041826004381 Putative Catalytic site; other site 1041826004382 DXD motif; other site 1041826004383 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1041826004384 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1041826004385 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1041826004386 putative RNA binding site [nucleotide binding]; other site 1041826004387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826004388 S-adenosylmethionine binding site [chemical binding]; other site 1041826004389 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1041826004390 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1041826004391 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1041826004392 active site 1041826004393 Zn binding site [ion binding]; other site 1041826004394 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004395 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1041826004396 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 1041826004397 four helix bundle protein; Region: TIGR02436 1041826004398 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1041826004399 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1041826004400 Transglycosylase; Region: Transgly; pfam00912 1041826004401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041826004402 GldH lipoprotein; Region: GldH_lipo; pfam14109 1041826004403 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1041826004404 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1041826004405 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1041826004406 Peptidase family U32; Region: Peptidase_U32; pfam01136 1041826004407 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1041826004408 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1041826004409 active site residue [active] 1041826004410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826004411 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1041826004412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826004413 Walker A/P-loop; other site 1041826004414 ATP binding site [chemical binding]; other site 1041826004415 Q-loop/lid; other site 1041826004416 ABC transporter signature motif; other site 1041826004417 Walker B; other site 1041826004418 D-loop; other site 1041826004419 H-loop/switch region; other site 1041826004420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1041826004421 binding surface 1041826004422 TPR motif; other site 1041826004423 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1041826004424 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1041826004425 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1041826004426 dimer interface [polypeptide binding]; other site 1041826004427 ssDNA binding site [nucleotide binding]; other site 1041826004428 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1041826004429 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1041826004430 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1041826004431 putative NAD(P) binding site [chemical binding]; other site 1041826004432 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1041826004433 EamA-like transporter family; Region: EamA; pfam00892 1041826004434 EamA-like transporter family; Region: EamA; pfam00892 1041826004435 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826004436 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826004437 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 1041826004438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1041826004439 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826004440 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1041826004441 Sporulation related domain; Region: SPOR; pfam05036 1041826004442 DNA protecting protein DprA; Region: dprA; TIGR00732 1041826004443 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1041826004444 Bacterial SH3 domain; Region: SH3_3; pfam08239 1041826004445 potential frameshift: common BLAST hit: gi|256424864|ref|YP_003125517.1| chitinase 1041826004446 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1041826004447 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1041826004448 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1041826004449 GH3 auxin-responsive promoter; Region: GH3; pfam03321 1041826004450 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1041826004451 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1041826004452 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1041826004453 putative DNA binding site [nucleotide binding]; other site 1041826004454 putative Zn2+ binding site [ion binding]; other site 1041826004455 AsnC family; Region: AsnC_trans_reg; pfam01037 1041826004456 Lyase; Region: Lyase_1; pfam00206 1041826004457 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1041826004458 tetramer interface [polypeptide binding]; other site 1041826004459 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 1041826004460 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1041826004461 metal binding site [ion binding]; metal-binding site 1041826004462 dimer interface [polypeptide binding]; other site 1041826004463 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1041826004464 nucleotide binding site [chemical binding]; other site 1041826004465 N-acetyl-L-glutamate binding site [chemical binding]; other site 1041826004466 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 1041826004467 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1041826004468 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1041826004469 acetylornithine aminotransferase; Provisional; Region: PRK02627 1041826004470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1041826004471 inhibitor-cofactor binding pocket; inhibition site 1041826004472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826004473 catalytic residue [active] 1041826004474 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1041826004475 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1041826004476 argininosuccinate synthase; Provisional; Region: PRK13820 1041826004477 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1041826004478 Ligand Binding Site [chemical binding]; other site 1041826004479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826004480 Coenzyme A binding pocket [chemical binding]; other site 1041826004481 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1041826004482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1041826004483 PAS domain; Region: PAS_9; pfam13426 1041826004484 putative active site [active] 1041826004485 heme pocket [chemical binding]; other site 1041826004486 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1041826004487 structural tetrad; other site 1041826004488 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1041826004489 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1041826004490 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1041826004491 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1041826004492 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1041826004493 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1041826004494 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1041826004495 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041826004496 RNA binding site [nucleotide binding]; other site 1041826004497 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 1041826004498 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826004499 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 1041826004500 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826004501 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 1041826004502 AAA domain; Region: AAA_14; pfam13173 1041826004503 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1041826004504 Predicted membrane protein [Function unknown]; Region: COG2860 1041826004505 UPF0126 domain; Region: UPF0126; pfam03458 1041826004506 UPF0126 domain; Region: UPF0126; pfam03458 1041826004507 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1041826004508 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1041826004509 ribonuclease R; Region: RNase_R; TIGR02063 1041826004510 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1041826004511 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1041826004512 RNB domain; Region: RNB; pfam00773 1041826004513 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1041826004514 RNA binding site [nucleotide binding]; other site 1041826004515 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1041826004516 LysE type translocator; Region: LysE; cl00565 1041826004517 GldM C-terminal domain; Region: GldM_C; pfam12080 1041826004518 potential protein location (hypothetical protein FCOL_08770 [Flavobacterium columnare ATCC 49512]) that overlaps RNA (tRNA-S) 1041826004519 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1041826004520 active site 1041826004521 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1041826004522 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004523 active site 1041826004524 HIGH motif; other site 1041826004525 nucleotide binding site [chemical binding]; other site 1041826004526 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004527 active site 1041826004528 KMSKS motif; other site 1041826004529 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1041826004530 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826004531 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1041826004532 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1041826004533 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1041826004534 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1041826004535 HIGH motif; other site 1041826004536 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1041826004537 active site 1041826004538 KMSKS motif; other site 1041826004539 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1041826004540 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1041826004541 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1041826004542 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1041826004543 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1041826004544 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1041826004545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826004546 S-adenosylmethionine binding site [chemical binding]; other site 1041826004547 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1041826004548 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1041826004549 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1041826004550 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1041826004551 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 1041826004552 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 1041826004553 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 1041826004554 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826004555 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 1041826004556 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 1041826004557 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 1041826004558 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1041826004559 Phosphoglycerate kinase; Region: PGK; pfam00162 1041826004560 substrate binding site [chemical binding]; other site 1041826004561 hinge regions; other site 1041826004562 ADP binding site [chemical binding]; other site 1041826004563 catalytic site [active] 1041826004564 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1041826004565 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1041826004566 catalytic residue [active] 1041826004567 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826004568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826004569 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826004570 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826004571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826004572 Coenzyme A binding pocket [chemical binding]; other site 1041826004573 potential frameshift: common BLAST hit: gi|120435941|ref|YP_861627.1| mutator family transposase 1041826004574 potential frameshift: common BLAST hit: gi|295132605|ref|YP_003583281.1| mutator family transposase 1041826004575 potential frameshift: common BLAST hit: gi|120435941|ref|YP_861627.1| mutator family transposase 1041826004576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1041826004577 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826004578 Coronavirus NSP13; Region: NSP13; pfam06460 1041826004579 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 1041826004580 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004581 active site 1041826004582 HIGH motif; other site 1041826004583 nucleotide binding site [chemical binding]; other site 1041826004584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004585 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1041826004586 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004587 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004588 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826004589 active site 1041826004590 KMSKS motif; other site 1041826004591 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1041826004592 tRNA binding surface [nucleotide binding]; other site 1041826004593 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 1041826004594 active site 1041826004595 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1041826004596 active site 1041826004597 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1041826004598 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 1041826004599 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1041826004600 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1041826004601 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1041826004602 RNA binding site [nucleotide binding]; other site 1041826004603 active site 1041826004604 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1041826004605 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1041826004606 thiS-thiF/thiG interaction site; other site 1041826004607 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1041826004608 ThiC-associated domain; Region: ThiC-associated; pfam13667 1041826004609 ThiC family; Region: ThiC; pfam01964 1041826004610 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1041826004611 active site 1041826004612 thiamine phosphate binding site [chemical binding]; other site 1041826004613 pyrophosphate binding site [ion binding]; other site 1041826004614 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1041826004615 substrate binding site [chemical binding]; other site 1041826004616 dimer interface [polypeptide binding]; other site 1041826004617 ATP binding site [chemical binding]; other site 1041826004618 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1041826004619 active site 1041826004620 thiamine phosphate binding site [chemical binding]; other site 1041826004621 pyrophosphate binding site [ion binding]; other site 1041826004622 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1041826004623 ThiS interaction site; other site 1041826004624 putative active site [active] 1041826004625 tetramer interface [polypeptide binding]; other site 1041826004626 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1041826004627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826004628 FeS/SAM binding site; other site 1041826004629 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1041826004630 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1041826004631 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1041826004632 ATP binding site [chemical binding]; other site 1041826004633 substrate interface [chemical binding]; other site 1041826004634 Peptidase family M48; Region: Peptidase_M48; pfam01435 1041826004635 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1041826004636 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1041826004637 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1041826004638 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1041826004639 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 1041826004640 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1041826004641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1041826004642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826004643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004644 ATP binding site [chemical binding]; other site 1041826004645 Mg2+ binding site [ion binding]; other site 1041826004646 G-X-G motif; other site 1041826004647 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1041826004648 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1041826004649 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1041826004650 Transglycosylase; Region: Transgly; cl17702 1041826004651 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1041826004652 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1041826004653 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1041826004654 protein binding site [polypeptide binding]; other site 1041826004655 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1041826004656 Catalytic dyad [active] 1041826004657 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1041826004658 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1041826004659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041826004660 putative DNA binding site [nucleotide binding]; other site 1041826004661 putative Zn2+ binding site [ion binding]; other site 1041826004662 AsnC family; Region: AsnC_trans_reg; pfam01037 1041826004663 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1041826004664 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1041826004665 NAD(P) binding pocket [chemical binding]; other site 1041826004666 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1041826004667 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1041826004668 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1041826004669 active site 1041826004670 substrate-binding site [chemical binding]; other site 1041826004671 metal-binding site [ion binding] 1041826004672 ATP binding site [chemical binding]; other site 1041826004673 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1041826004674 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1041826004675 FMN binding site [chemical binding]; other site 1041826004676 active site 1041826004677 catalytic residues [active] 1041826004678 substrate binding site [chemical binding]; other site 1041826004679 GTP-binding protein LepA; Provisional; Region: PRK05433 1041826004680 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1041826004681 G1 box; other site 1041826004682 putative GEF interaction site [polypeptide binding]; other site 1041826004683 GTP/Mg2+ binding site [chemical binding]; other site 1041826004684 Switch I region; other site 1041826004685 G2 box; other site 1041826004686 G3 box; other site 1041826004687 Switch II region; other site 1041826004688 G4 box; other site 1041826004689 G5 box; other site 1041826004690 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1041826004691 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1041826004692 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1041826004693 amino acid transporter; Region: 2A0306; TIGR00909 1041826004694 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1041826004695 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1041826004696 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1041826004697 active site 1041826004698 nucleophile elbow; other site 1041826004699 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1041826004700 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1041826004701 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1041826004702 GIY-YIG motif/motif A; other site 1041826004703 active site 1041826004704 catalytic site [active] 1041826004705 putative DNA binding site [nucleotide binding]; other site 1041826004706 metal binding site [ion binding]; metal-binding site 1041826004707 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1041826004708 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1041826004709 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1041826004710 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1041826004711 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1041826004712 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1041826004713 putative recombination protein RecB; Provisional; Region: PRK13909 1041826004714 Family description; Region: UvrD_C_2; pfam13538 1041826004715 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1041826004716 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1041826004717 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1041826004718 substrate-cofactor binding pocket; other site 1041826004719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826004720 catalytic residue [active] 1041826004721 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826004722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826004723 ligand binding site [chemical binding]; other site 1041826004724 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1041826004725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1041826004726 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1041826004727 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1041826004728 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1041826004729 proline aminopeptidase P II; Provisional; Region: PRK10879 1041826004730 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1041826004731 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1041826004732 active site 1041826004733 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1041826004734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1041826004735 ligand binding site [chemical binding]; other site 1041826004736 flexible hinge region; other site 1041826004737 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1041826004738 BNR repeat-like domain; Region: BNR_2; pfam13088 1041826004739 VPS10 domain; Region: VPS10; smart00602 1041826004740 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1041826004741 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1041826004742 proximal heme binding site [chemical binding]; other site 1041826004743 putative dimer interface [polypeptide binding]; other site 1041826004744 putative Iron-sulfur protein interface [polypeptide binding]; other site 1041826004745 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1041826004746 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1041826004747 L-aspartate oxidase; Provisional; Region: PRK06175 1041826004748 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1041826004749 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1041826004750 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1041826004751 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 1041826004752 TPR repeat; Region: TPR_11; pfam13414 1041826004753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826004754 binding surface 1041826004755 TPR motif; other site 1041826004756 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1041826004757 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041826004758 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1041826004759 NodB motif; other site 1041826004760 active site 1041826004761 catalytic site [active] 1041826004762 metal binding site [ion binding]; metal-binding site 1041826004763 C-N hydrolase family amidase; Provisional; Region: PRK10438 1041826004764 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1041826004765 putative active site [active] 1041826004766 catalytic triad [active] 1041826004767 dimer interface [polypeptide binding]; other site 1041826004768 multimer interface [polypeptide binding]; other site 1041826004769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826004770 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826004771 Predicted transcriptional regulator [Transcription]; Region: COG2932 1041826004772 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1041826004773 Catalytic site [active] 1041826004774 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1041826004775 active site 1041826004776 nucleophile elbow; other site 1041826004777 Transposase IS200 like; Region: Y1_Tnp; cl00848 1041826004778 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1041826004779 Bacterial Ig-like domain; Region: Big_5; pfam13205 1041826004780 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1041826004781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826004782 active site 1041826004783 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1041826004784 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1041826004785 motif 1; other site 1041826004786 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1041826004787 active site 1041826004788 motif 2; other site 1041826004789 motif 3; other site 1041826004790 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1041826004791 anticodon binding site; other site 1041826004792 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1041826004793 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1041826004794 ATP binding site [chemical binding]; other site 1041826004795 dimerization interface [polypeptide binding]; other site 1041826004796 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1041826004797 Integrase core domain; Region: rve; pfam00665 1041826004798 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1041826004799 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1041826004800 RHS Repeat; Region: RHS_repeat; pfam05593 1041826004801 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1041826004802 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1041826004803 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1041826004804 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1041826004805 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826004806 hypothetical protein; Provisional; Region: PRK08201 1041826004807 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1041826004808 metal binding site [ion binding]; metal-binding site 1041826004809 putative dimer interface [polypeptide binding]; other site 1041826004810 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826004811 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1041826004812 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826004813 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1041826004814 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1041826004815 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1041826004816 FeoA domain; Region: FeoA; pfam04023 1041826004817 manganese transport protein MntH; Reviewed; Region: PRK00701 1041826004818 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1041826004819 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1041826004820 Ligand Binding Site [chemical binding]; other site 1041826004821 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1041826004822 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1041826004823 G1 box; other site 1041826004824 GTP/Mg2+ binding site [chemical binding]; other site 1041826004825 Switch I region; other site 1041826004826 G2 box; other site 1041826004827 G3 box; other site 1041826004828 Switch II region; other site 1041826004829 G4 box; other site 1041826004830 G5 box; other site 1041826004831 Nucleoside recognition; Region: Gate; pfam07670 1041826004832 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1041826004833 FeoA domain; Region: FeoA; pfam04023 1041826004834 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1041826004835 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1041826004836 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 1041826004837 active site 1041826004838 catalytic site [active] 1041826004839 substrate binding site [chemical binding]; other site 1041826004840 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1041826004841 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1041826004842 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1041826004843 DNA binding site [nucleotide binding] 1041826004844 active site 1041826004845 Cytochrome c; Region: Cytochrom_C; cl11414 1041826004846 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1041826004847 dimer interface [polypeptide binding]; other site 1041826004848 allosteric magnesium binding site [ion binding]; other site 1041826004849 active site 1041826004850 aspartate-rich active site metal binding site; other site 1041826004851 Schiff base residues; other site 1041826004852 Domain of unknown function (DUF4421); Region: DUF4421; pfam14391 1041826004853 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1041826004854 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1041826004855 Protein of unknown function (DUF3575); Region: DUF3575; pfam12099 1041826004856 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1041826004857 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1041826004858 substrate binding site [chemical binding]; other site 1041826004859 active site 1041826004860 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1041826004861 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1041826004862 active site 1041826004863 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1041826004864 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1041826004865 domain interfaces; other site 1041826004866 active site 1041826004867 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1041826004868 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1041826004869 NAD(P) binding pocket [chemical binding]; other site 1041826004870 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1041826004871 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1041826004872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041826004873 ferrochelatase; Reviewed; Region: hemH; PRK00035 1041826004874 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1041826004875 C-terminal domain interface [polypeptide binding]; other site 1041826004876 active site 1041826004877 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1041826004878 active site 1041826004879 N-terminal domain interface [polypeptide binding]; other site 1041826004880 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1041826004881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826004882 HAMP domain; Region: HAMP; pfam00672 1041826004883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1041826004884 dimer interface [polypeptide binding]; other site 1041826004885 phosphorylation site [posttranslational modification] 1041826004886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826004887 ATP binding site [chemical binding]; other site 1041826004888 Mg2+ binding site [ion binding]; other site 1041826004889 G-X-G motif; other site 1041826004890 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1041826004891 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1041826004892 substrate binding site [chemical binding]; other site 1041826004893 oxyanion hole (OAH) forming residues; other site 1041826004894 trimer interface [polypeptide binding]; other site 1041826004895 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1041826004896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1041826004897 Zn2+ binding site [ion binding]; other site 1041826004898 Mg2+ binding site [ion binding]; other site 1041826004899 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1041826004900 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1041826004901 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1041826004902 homodimer interface [polypeptide binding]; other site 1041826004903 putative substrate binding pocket [chemical binding]; other site 1041826004904 diiron center [ion binding]; other site 1041826004905 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826004906 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1041826004907 putative acyl-acceptor binding pocket; other site 1041826004908 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1041826004909 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1041826004910 Peptidase family M23; Region: Peptidase_M23; pfam01551 1041826004911 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 1041826004912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826004913 binding surface 1041826004914 TPR motif; other site 1041826004915 TPR repeat; Region: TPR_11; pfam13414 1041826004916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1041826004917 binding surface 1041826004918 TPR motif; other site 1041826004919 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 1041826004920 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1041826004921 active site 1041826004922 Substrate binding site; other site 1041826004923 Mg++ binding site; other site 1041826004924 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1041826004925 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1041826004926 trimer interface [polypeptide binding]; other site 1041826004927 active site 1041826004928 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1041826004929 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041826004930 seryl-tRNA synthetase; Provisional; Region: PRK05431 1041826004931 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1041826004932 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1041826004933 dimer interface [polypeptide binding]; other site 1041826004934 active site 1041826004935 motif 1; other site 1041826004936 motif 2; other site 1041826004937 motif 3; other site 1041826004938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826004939 binding surface 1041826004940 TPR motif; other site 1041826004941 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1041826004942 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 1041826004943 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1041826004944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826004945 S-adenosylmethionine binding site [chemical binding]; other site 1041826004946 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1041826004947 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1041826004948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1041826004949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1041826004950 Divalent cation transporter; Region: MgtE; pfam01769 1041826004951 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826004952 putative transposase OrfB; Reviewed; Region: PHA02517 1041826004953 HTH-like domain; Region: HTH_21; pfam13276 1041826004954 Integrase core domain; Region: rve; pfam00665 1041826004955 Integrase core domain; Region: rve_3; pfam13683 1041826004956 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1041826004957 DNA-binding interface [nucleotide binding]; DNA binding site 1041826004958 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1041826004959 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 1041826004960 putative ligand binding site [chemical binding]; other site 1041826004961 putative NAD binding site [chemical binding]; other site 1041826004962 catalytic site [active] 1041826004963 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1041826004964 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826004965 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1041826004966 active site 1041826004967 catalytic site [active] 1041826004968 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1041826004969 putative active site [active] 1041826004970 putative metal binding site [ion binding]; other site 1041826004971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826004972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1041826004973 putative substrate translocation pore; other site 1041826004974 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1041826004975 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1041826004976 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1041826004977 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1041826004978 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1041826004979 E3 interaction surface; other site 1041826004980 lipoyl attachment site [posttranslational modification]; other site 1041826004981 e3 binding domain; Region: E3_binding; pfam02817 1041826004982 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1041826004983 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1041826004984 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1041826004985 TPP-binding site [chemical binding]; other site 1041826004986 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1041826004987 dimer interface [polypeptide binding]; other site 1041826004988 PYR/PP interface [polypeptide binding]; other site 1041826004989 TPP binding site [chemical binding]; other site 1041826004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1041826004991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1041826004992 putative substrate translocation pore; other site 1041826004993 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1041826004994 putative active site [active] 1041826004995 putative metal binding site [ion binding]; other site 1041826004996 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1041826004997 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1041826004998 substrate binding pocket [chemical binding]; other site 1041826004999 chain length determination region; other site 1041826005000 substrate-Mg2+ binding site; other site 1041826005001 catalytic residues [active] 1041826005002 aspartate-rich region 1; other site 1041826005003 active site lid residues [active] 1041826005004 aspartate-rich region 2; other site 1041826005005 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1041826005006 classical (c) SDRs; Region: SDR_c; cd05233 1041826005007 NAD(P) binding site [chemical binding]; other site 1041826005008 active site 1041826005009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1041826005010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1041826005011 Outer membrane efflux protein; Region: OEP; pfam02321 1041826005012 Outer membrane efflux protein; Region: OEP; pfam02321 1041826005013 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1041826005014 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041826005015 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826005016 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1041826005017 Protein export membrane protein; Region: SecD_SecF; cl14618 1041826005018 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826005019 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826005020 ligand binding site [chemical binding]; other site 1041826005021 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1041826005022 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826005023 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1041826005024 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1041826005025 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1041826005026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826005027 Walker A motif; other site 1041826005028 ATP binding site [chemical binding]; other site 1041826005029 Walker B motif; other site 1041826005030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826005031 Walker A motif; other site 1041826005032 ATP binding site [chemical binding]; other site 1041826005033 Walker B motif; other site 1041826005034 arginine finger; other site 1041826005035 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1041826005036 FOG: PKD repeat [General function prediction only]; Region: COG3291 1041826005037 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1041826005038 PKD domain; Region: PKD; pfam00801 1041826005039 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1041826005040 NlpC/P60 family; Region: NLPC_P60; cl17555 1041826005041 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1041826005042 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1041826005043 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1041826005044 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1041826005045 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1041826005046 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1041826005047 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1041826005048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1041826005049 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1041826005050 periplasmic chaperone; Provisional; Region: PRK10780 1041826005051 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1041826005052 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 1041826005053 dimer interface [polypeptide binding]; other site 1041826005054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041826005055 non-specific DNA binding site [nucleotide binding]; other site 1041826005056 salt bridge; other site 1041826005057 sequence-specific DNA binding site [nucleotide binding]; other site 1041826005058 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1041826005059 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826005060 active site 1041826005061 DNA binding site [nucleotide binding] 1041826005062 Int/Topo IB signature motif; other site 1041826005063 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1041826005064 active site 1041826005065 catalytic residues [active] 1041826005066 DNA binding site [nucleotide binding] 1041826005067 Int/Topo IB signature motif; other site 1041826005068 Winged helix-turn helix; Region: HTH_29; pfam13551 1041826005069 Helix-turn-helix domain; Region: HTH_28; pfam13518 1041826005070 Integrase core domain; Region: rve; pfam00665 1041826005071 SlyX; Region: SlyX; cl01090 1041826005072 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1041826005073 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1041826005074 Walker A motif; other site 1041826005075 ATP binding site [chemical binding]; other site 1041826005076 Walker B motif; other site 1041826005077 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1041826005078 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1041826005079 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1041826005080 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1041826005081 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 1041826005082 PA/protease or protease-like domain interface [polypeptide binding]; other site 1041826005083 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826005084 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826005085 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1041826005086 putative acyl-acceptor binding pocket; other site 1041826005087 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1041826005088 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1041826005089 active site 1041826005090 HIGH motif; other site 1041826005091 dimer interface [polypeptide binding]; other site 1041826005092 KMSKS motif; other site 1041826005093 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1041826005094 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1041826005095 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1041826005096 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1041826005097 active site 1041826005098 dimer interface [polypeptide binding]; other site 1041826005099 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1041826005100 dimer interface [polypeptide binding]; other site 1041826005101 active site 1041826005102 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826005103 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826005104 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826005105 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826005106 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1041826005107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826005108 Coenzyme A binding pocket [chemical binding]; other site 1041826005109 Putative cyclase; Region: Cyclase; pfam04199 1041826005110 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1041826005111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826005112 FeS/SAM binding site; other site 1041826005113 HemN C-terminal domain; Region: HemN_C; pfam06969 1041826005114 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1041826005115 active site 1041826005116 putative DNA-binding cleft [nucleotide binding]; other site 1041826005117 dimer interface [polypeptide binding]; other site 1041826005118 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1041826005119 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 1041826005120 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1041826005121 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1041826005122 putative active site [active] 1041826005123 catalytic residue [active] 1041826005124 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1041826005125 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1041826005126 5S rRNA interface [nucleotide binding]; other site 1041826005127 CTC domain interface [polypeptide binding]; other site 1041826005128 L16 interface [polypeptide binding]; other site 1041826005129 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1041826005130 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1041826005131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826005132 active site 1041826005133 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 1041826005134 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1041826005135 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1041826005136 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 1041826005137 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1041826005138 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1041826005139 active site 1041826005140 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1041826005141 Ribosome-binding factor A; Region: RBFA; pfam02033 1041826005142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1041826005143 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1041826005144 dimer interface [polypeptide binding]; other site 1041826005145 substrate binding site [chemical binding]; other site 1041826005146 metal binding site [ion binding]; metal-binding site 1041826005147 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1041826005148 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1041826005149 active site 1041826005150 catalytic site [active] 1041826005151 substrate binding site [chemical binding]; other site 1041826005152 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1041826005153 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1041826005154 active site 1041826005155 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1041826005156 generic binding surface I; other site 1041826005157 generic binding surface II; other site 1041826005158 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1041826005159 active site 1041826005160 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826005161 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1041826005162 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1041826005163 active site 1041826005164 Riboflavin kinase; Region: Flavokinase; pfam01687 1041826005165 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1041826005166 amphipathic channel; other site 1041826005167 Asn-Pro-Ala signature motifs; other site 1041826005168 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1041826005169 biotin synthase; Region: bioB; TIGR00433 1041826005170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826005171 FeS/SAM binding site; other site 1041826005172 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1041826005173 recombinase A; Provisional; Region: recA; PRK09354 1041826005174 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1041826005175 hexamer interface [polypeptide binding]; other site 1041826005176 Walker A motif; other site 1041826005177 ATP binding site [chemical binding]; other site 1041826005178 Walker B motif; other site 1041826005179 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1041826005180 nucleotide binding site/active site [active] 1041826005181 HIT family signature motif; other site 1041826005182 catalytic residue [active] 1041826005183 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1041826005184 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1041826005185 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1041826005186 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1041826005187 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1041826005188 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1041826005189 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1041826005190 dimer interface [polypeptide binding]; other site 1041826005191 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1041826005192 active site 1041826005193 Fe binding site [ion binding]; other site 1041826005194 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1041826005195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826005196 S-adenosylmethionine binding site [chemical binding]; other site 1041826005197 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1041826005198 RimM N-terminal domain; Region: RimM; pfam01782 1041826005199 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 1041826005200 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1041826005201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1041826005202 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826005203 catalytic residues [active] 1041826005204 Protein of unknown function DUF58; Region: DUF58; pfam01882 1041826005205 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1041826005206 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1041826005207 dimer interface [polypeptide binding]; other site 1041826005208 anticodon binding site; other site 1041826005209 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1041826005210 homodimer interface [polypeptide binding]; other site 1041826005211 motif 1; other site 1041826005212 active site 1041826005213 motif 2; other site 1041826005214 GAD domain; Region: GAD; pfam02938 1041826005215 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1041826005216 motif 3; other site 1041826005217 potential frameshift: common BLAST hit: gi|150024123|ref|YP_001294949.1| cAMP-binding protein 1041826005218 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1041826005219 DNA-binding site [nucleotide binding]; DNA binding site 1041826005220 RNA-binding motif; other site 1041826005221 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1041826005222 nucleoside/Zn binding site; other site 1041826005223 dimer interface [polypeptide binding]; other site 1041826005224 catalytic motif [active] 1041826005225 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1041826005226 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1041826005227 TPP-binding site; other site 1041826005228 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1041826005229 PYR/PP interface [polypeptide binding]; other site 1041826005230 dimer interface [polypeptide binding]; other site 1041826005231 TPP binding site [chemical binding]; other site 1041826005232 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1041826005233 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1041826005234 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 1041826005235 PA/protease or protease-like domain interface [polypeptide binding]; other site 1041826005236 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1041826005237 Zn binding site [ion binding]; other site 1041826005238 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826005239 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1041826005240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826005241 Coenzyme A binding pocket [chemical binding]; other site 1041826005242 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 1041826005243 ATP cone domain; Region: ATP-cone; pfam03477 1041826005244 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1041826005245 active site 1041826005246 dimer interface [polypeptide binding]; other site 1041826005247 catalytic residues [active] 1041826005248 effector binding site; other site 1041826005249 R2 peptide binding site; other site 1041826005250 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1041826005251 dimer interface [polypeptide binding]; other site 1041826005252 putative radical transfer pathway; other site 1041826005253 diiron center [ion binding]; other site 1041826005254 tyrosyl radical; other site 1041826005255 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 1041826005256 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1041826005257 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1041826005258 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1041826005259 catalytic motif [active] 1041826005260 Zn binding site [ion binding]; other site 1041826005261 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1041826005262 universal stress protein UspE; Provisional; Region: PRK11175 1041826005263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1041826005264 Ligand Binding Site [chemical binding]; other site 1041826005265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1041826005266 Ligand Binding Site [chemical binding]; other site 1041826005267 Sm and related proteins; Region: Sm_like; cl00259 1041826005268 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1041826005269 Sm1 motif; other site 1041826005270 RNA binding site [nucleotide binding]; other site 1041826005271 transcription termination factor NusA; Region: NusA; TIGR01953 1041826005272 NusA N-terminal domain; Region: NusA_N; pfam08529 1041826005273 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1041826005274 RNA binding site [nucleotide binding]; other site 1041826005275 homodimer interface [polypeptide binding]; other site 1041826005276 NusA-like KH domain; Region: KH_5; pfam13184 1041826005277 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1041826005278 G-X-X-G motif; other site 1041826005279 translation initiation factor IF-2; Region: IF-2; TIGR00487 1041826005280 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1041826005281 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1041826005282 G1 box; other site 1041826005283 putative GEF interaction site [polypeptide binding]; other site 1041826005284 GTP/Mg2+ binding site [chemical binding]; other site 1041826005285 Switch I region; other site 1041826005286 G2 box; other site 1041826005287 G3 box; other site 1041826005288 Switch II region; other site 1041826005289 G4 box; other site 1041826005290 G5 box; other site 1041826005291 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1041826005292 Translation-initiation factor 2; Region: IF-2; pfam11987 1041826005293 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1041826005294 L-type amino acid transporter; Region: 2A0308; TIGR00911 1041826005295 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1041826005296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826005297 Walker A motif; other site 1041826005298 ATP binding site [chemical binding]; other site 1041826005299 Walker B motif; other site 1041826005300 arginine finger; other site 1041826005301 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1041826005302 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1041826005303 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1041826005304 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1041826005305 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1041826005306 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1041826005307 putative NAD(P) binding site [chemical binding]; other site 1041826005308 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1041826005309 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1041826005310 RuvA N terminal domain; Region: RuvA_N; pfam01330 1041826005311 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1041826005312 cell surface protein SprA; Region: surface_SprA; TIGR04189 1041826005313 Motility related/secretion protein; Region: SprA_N; pfam14349 1041826005314 Motility related/secretion protein; Region: SprA_N; pfam14349 1041826005315 Motility related/secretion protein; Region: SprA_N; pfam14349 1041826005316 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1041826005317 lipoyl attachment site [posttranslational modification]; other site 1041826005318 Predicted integral membrane protein [Function unknown]; Region: COG5652 1041826005319 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1041826005320 intersubunit interface [polypeptide binding]; other site 1041826005321 active site 1041826005322 catalytic residue [active] 1041826005323 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1041826005324 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1041826005325 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826005326 ligand binding site [chemical binding]; other site 1041826005327 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 1041826005328 Domain of unknown function DUF11; Region: DUF11; pfam01345 1041826005329 Translocon-associated protein beta (TRAPB); Region: TRAP_beta; pfam05753 1041826005330 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 1041826005331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1041826005332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826005333 active site 1041826005334 phosphorylation site [posttranslational modification] 1041826005335 intermolecular recognition site; other site 1041826005336 dimerization interface [polypeptide binding]; other site 1041826005337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1041826005338 DNA binding residues [nucleotide binding] 1041826005339 dimerization interface [polypeptide binding]; other site 1041826005340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1041826005341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1041826005342 dimer interface [polypeptide binding]; other site 1041826005343 phosphorylation site [posttranslational modification] 1041826005344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826005345 ATP binding site [chemical binding]; other site 1041826005346 Mg2+ binding site [ion binding]; other site 1041826005347 G-X-G motif; other site 1041826005348 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1041826005349 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1041826005350 G1 box; other site 1041826005351 putative GEF interaction site [polypeptide binding]; other site 1041826005352 GTP/Mg2+ binding site [chemical binding]; other site 1041826005353 Switch I region; other site 1041826005354 G2 box; other site 1041826005355 G3 box; other site 1041826005356 Switch II region; other site 1041826005357 G4 box; other site 1041826005358 G5 box; other site 1041826005359 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1041826005360 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1041826005361 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1041826005362 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1041826005363 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1041826005364 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1041826005365 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1041826005366 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1041826005367 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1041826005368 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1041826005369 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1041826005370 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1041826005371 DNA binding site [nucleotide binding] 1041826005372 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1041826005373 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1041826005374 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1041826005375 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1041826005376 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1041826005377 RPB11 interaction site [polypeptide binding]; other site 1041826005378 RPB12 interaction site [polypeptide binding]; other site 1041826005379 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1041826005380 RPB3 interaction site [polypeptide binding]; other site 1041826005381 RPB1 interaction site [polypeptide binding]; other site 1041826005382 RPB11 interaction site [polypeptide binding]; other site 1041826005383 RPB10 interaction site [polypeptide binding]; other site 1041826005384 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1041826005385 core dimer interface [polypeptide binding]; other site 1041826005386 peripheral dimer interface [polypeptide binding]; other site 1041826005387 L10 interface [polypeptide binding]; other site 1041826005388 L11 interface [polypeptide binding]; other site 1041826005389 putative EF-Tu interaction site [polypeptide binding]; other site 1041826005390 putative EF-G interaction site [polypeptide binding]; other site 1041826005391 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1041826005392 23S rRNA interface [nucleotide binding]; other site 1041826005393 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1041826005394 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1041826005395 mRNA/rRNA interface [nucleotide binding]; other site 1041826005396 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1041826005397 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1041826005398 23S rRNA interface [nucleotide binding]; other site 1041826005399 L7/L12 interface [polypeptide binding]; other site 1041826005400 putative thiostrepton binding site; other site 1041826005401 L25 interface [polypeptide binding]; other site 1041826005402 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1041826005403 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1041826005404 putative homodimer interface [polypeptide binding]; other site 1041826005405 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1041826005406 heterodimer interface [polypeptide binding]; other site 1041826005407 homodimer interface [polypeptide binding]; other site 1041826005408 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1041826005409 elongation factor Tu; Reviewed; Region: PRK12735 1041826005410 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1041826005411 G1 box; other site 1041826005412 GEF interaction site [polypeptide binding]; other site 1041826005413 GTP/Mg2+ binding site [chemical binding]; other site 1041826005414 Switch I region; other site 1041826005415 G2 box; other site 1041826005416 G3 box; other site 1041826005417 Switch II region; other site 1041826005418 G4 box; other site 1041826005419 G5 box; other site 1041826005420 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1041826005421 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1041826005422 Antibiotic Binding Site [chemical binding]; other site 1041826005423 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1041826005424 30S subunit binding site; other site 1041826005425 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1041826005426 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826005427 active site 1041826005428 DNA binding site [nucleotide binding] 1041826005429 Int/Topo IB signature motif; other site 1041826005430 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1041826005431 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1041826005432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1041826005433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1041826005434 active site 1041826005435 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1041826005436 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1041826005437 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 1041826005438 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1041826005439 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1041826005440 dimer interface [polypeptide binding]; other site 1041826005441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826005442 catalytic residue [active] 1041826005443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1041826005444 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 1041826005445 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 1041826005446 starch binding outer membrane protein SusD; Region: SusD; cd08977 1041826005447 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 1041826005448 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826005449 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1041826005450 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826005451 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1041826005452 RNA/DNA hybrid binding site [nucleotide binding]; other site 1041826005453 active site 1041826005454 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 1041826005455 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1041826005456 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1041826005457 dimer interface [polypeptide binding]; other site 1041826005458 putative anticodon binding site; other site 1041826005459 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1041826005460 motif 1; other site 1041826005461 active site 1041826005462 motif 2; other site 1041826005463 motif 3; other site 1041826005464 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1041826005465 putative sugar binding site [chemical binding]; other site 1041826005466 catalytic residues [active] 1041826005467 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826005468 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826005469 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1041826005470 N-terminal plug; other site 1041826005471 ligand-binding site [chemical binding]; other site 1041826005472 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1041826005473 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 1041826005474 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826005475 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1041826005476 YtkA-like; Region: YtkA; pfam13115 1041826005477 Copper resistance protein D; Region: CopD; cl00563 1041826005478 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1041826005479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1041826005480 Walker A/P-loop; other site 1041826005481 ATP binding site [chemical binding]; other site 1041826005482 Q-loop/lid; other site 1041826005483 ABC transporter signature motif; other site 1041826005484 Walker B; other site 1041826005485 D-loop; other site 1041826005486 H-loop/switch region; other site 1041826005487 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1041826005488 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1041826005489 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 1041826005490 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1041826005491 Cytochrome c; Region: Cytochrom_C; pfam00034 1041826005492 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1041826005493 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1041826005494 inhibitor-cofactor binding pocket; inhibition site 1041826005495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826005496 catalytic residue [active] 1041826005497 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1041826005498 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1041826005499 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1041826005500 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1041826005501 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1041826005502 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826005503 catalytic residue [active] 1041826005504 potential frameshift: common BLAST hit: gi|255535561|ref|YP_003095932.1| urocanate hydratase 1041826005505 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1041826005506 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1041826005507 heme-binding site [chemical binding]; other site 1041826005508 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1041826005509 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1041826005510 cofactor binding site; other site 1041826005511 metal binding site [ion binding]; metal-binding site 1041826005512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826005513 active site residue [active] 1041826005514 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 1041826005515 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1041826005516 transcription termination factor Rho; Provisional; Region: PRK12608 1041826005517 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1041826005518 RNA binding site [nucleotide binding]; other site 1041826005519 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1041826005520 multimer interface [polypeptide binding]; other site 1041826005521 Walker A motif; other site 1041826005522 ATP binding site [chemical binding]; other site 1041826005523 Walker B motif; other site 1041826005524 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1041826005525 GSCFA family; Region: GSCFA; pfam08885 1041826005526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1041826005527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1041826005528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826005529 Walker A/P-loop; other site 1041826005530 ATP binding site [chemical binding]; other site 1041826005531 Q-loop/lid; other site 1041826005532 ABC transporter signature motif; other site 1041826005533 Walker B; other site 1041826005534 D-loop; other site 1041826005535 H-loop/switch region; other site 1041826005536 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1041826005537 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1041826005538 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1041826005539 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 1041826005540 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1041826005541 heme-binding site [chemical binding]; other site 1041826005542 GTPase Era; Reviewed; Region: era; PRK00089 1041826005543 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1041826005544 G1 box; other site 1041826005545 GTP/Mg2+ binding site [chemical binding]; other site 1041826005546 Switch I region; other site 1041826005547 G2 box; other site 1041826005548 Switch II region; other site 1041826005549 G3 box; other site 1041826005550 G4 box; other site 1041826005551 G5 box; other site 1041826005552 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826005553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826005554 GTP-binding protein Der; Reviewed; Region: PRK00093 1041826005555 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1041826005556 G1 box; other site 1041826005557 GTP/Mg2+ binding site [chemical binding]; other site 1041826005558 Switch I region; other site 1041826005559 G2 box; other site 1041826005560 Switch II region; other site 1041826005561 G3 box; other site 1041826005562 G4 box; other site 1041826005563 G5 box; other site 1041826005564 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1041826005565 G1 box; other site 1041826005566 GTP/Mg2+ binding site [chemical binding]; other site 1041826005567 Switch I region; other site 1041826005568 G2 box; other site 1041826005569 G3 box; other site 1041826005570 Switch II region; other site 1041826005571 G4 box; other site 1041826005572 G5 box; other site 1041826005573 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 1041826005574 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1041826005575 Interdomain contacts; other site 1041826005576 Cytokine receptor motif; other site 1041826005577 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1041826005578 Interdomain contacts; other site 1041826005579 Cytokine receptor motif; other site 1041826005580 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826005581 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1041826005582 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1041826005583 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 1041826005584 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1041826005585 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1041826005586 dimer interface [polypeptide binding]; other site 1041826005587 NADP binding site [chemical binding]; other site 1041826005588 catalytic residues [active] 1041826005589 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1041826005590 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1041826005591 inhibitor site; inhibition site 1041826005592 active site 1041826005593 dimer interface [polypeptide binding]; other site 1041826005594 catalytic residue [active] 1041826005595 Cupin domain; Region: Cupin_2; pfam07883 1041826005596 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1041826005597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1041826005598 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1041826005599 Repair protein; Region: Repair_PSII; pfam04536 1041826005600 Repair protein; Region: Repair_PSII; pfam04536 1041826005601 LemA family; Region: LemA; pfam04011 1041826005602 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1041826005603 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1041826005604 DNA binding residues [nucleotide binding] 1041826005605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826005606 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826005607 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1041826005608 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1041826005609 Peptidase family M23; Region: Peptidase_M23; pfam01551 1041826005610 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1041826005611 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1041826005612 motif 1; other site 1041826005613 active site 1041826005614 motif 2; other site 1041826005615 motif 3; other site 1041826005616 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1041826005617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041826005618 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826005619 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1041826005620 DXD motif; other site 1041826005621 Permease; Region: Permease; pfam02405 1041826005622 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1041826005623 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1041826005624 Walker A/P-loop; other site 1041826005625 ATP binding site [chemical binding]; other site 1041826005626 Q-loop/lid; other site 1041826005627 ABC transporter signature motif; other site 1041826005628 Walker B; other site 1041826005629 D-loop; other site 1041826005630 H-loop/switch region; other site 1041826005631 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1041826005632 putative catalytic site [active] 1041826005633 metal binding site A [ion binding]; metal-binding site 1041826005634 phosphate binding site [ion binding]; other site 1041826005635 metal binding site C [ion binding]; metal-binding site 1041826005636 metal binding site B [ion binding]; metal-binding site 1041826005637 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1041826005638 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1041826005639 Substrate binding site; other site 1041826005640 SprT homologues; Region: SprT; cl01182 1041826005641 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1041826005642 classical (c) SDRs; Region: SDR_c; cd05233 1041826005643 NAD(P) binding site [chemical binding]; other site 1041826005644 active site 1041826005645 M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021 1041826005646 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041826005647 metal binding site [ion binding]; metal-binding site 1041826005648 Peptidase family S41; Region: Peptidase_S41; pfam03572 1041826005649 Active site serine [active] 1041826005650 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1041826005651 E3 interaction surface; other site 1041826005652 lipoyl attachment site [posttranslational modification]; other site 1041826005653 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1041826005654 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1041826005655 E3 interaction surface; other site 1041826005656 lipoyl attachment site [posttranslational modification]; other site 1041826005657 e3 binding domain; Region: E3_binding; pfam02817 1041826005658 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1041826005659 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1041826005660 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1041826005661 tetramer interface [polypeptide binding]; other site 1041826005662 TPP-binding site [chemical binding]; other site 1041826005663 heterodimer interface [polypeptide binding]; other site 1041826005664 phosphorylation loop region [posttranslational modification] 1041826005665 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1041826005666 active site 1041826005667 catalytic motif [active] 1041826005668 Zn binding site [ion binding]; other site 1041826005669 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 1041826005670 active site 1041826005671 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 1041826005672 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041826005673 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1041826005674 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826005675 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041826005676 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826005677 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826005678 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1041826005679 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1041826005680 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1041826005681 Winged helix-turn helix; Region: HTH_29; pfam13551 1041826005682 Helix-turn-helix domain; Region: HTH_28; pfam13518 1041826005683 Integrase core domain; Region: rve; pfam00665 1041826005684 Integrase core domain; Region: rve_3; pfam13683 1041826005685 enolase; Provisional; Region: eno; PRK00077 1041826005686 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1041826005687 dimer interface [polypeptide binding]; other site 1041826005688 metal binding site [ion binding]; metal-binding site 1041826005689 substrate binding pocket [chemical binding]; other site 1041826005690 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1041826005691 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1041826005692 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1041826005693 catalytic site [active] 1041826005694 subunit interface [polypeptide binding]; other site 1041826005695 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1041826005696 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1041826005697 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1041826005698 alphaNTD homodimer interface [polypeptide binding]; other site 1041826005699 alphaNTD - beta interaction site [polypeptide binding]; other site 1041826005700 alphaNTD - beta' interaction site [polypeptide binding]; other site 1041826005701 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1041826005702 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1041826005703 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1041826005704 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1041826005705 RNA binding surface [nucleotide binding]; other site 1041826005706 30S ribosomal protein S11; Validated; Region: PRK05309 1041826005707 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1041826005708 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1041826005709 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1041826005710 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1041826005711 rRNA binding site [nucleotide binding]; other site 1041826005712 predicted 30S ribosome binding site; other site 1041826005713 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1041826005714 SecY translocase; Region: SecY; pfam00344 1041826005715 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1041826005716 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1041826005717 23S rRNA binding site [nucleotide binding]; other site 1041826005718 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1041826005719 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1041826005720 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1041826005721 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1041826005722 5S rRNA interface [nucleotide binding]; other site 1041826005723 L27 interface [polypeptide binding]; other site 1041826005724 23S rRNA interface [nucleotide binding]; other site 1041826005725 L5 interface [polypeptide binding]; other site 1041826005726 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1041826005727 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1041826005728 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1041826005729 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1041826005730 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1041826005731 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1041826005732 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1041826005733 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1041826005734 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1041826005735 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1041826005736 RNA binding site [nucleotide binding]; other site 1041826005737 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1041826005738 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1041826005739 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1041826005740 23S rRNA interface [nucleotide binding]; other site 1041826005741 putative translocon interaction site; other site 1041826005742 signal recognition particle (SRP54) interaction site; other site 1041826005743 L23 interface [polypeptide binding]; other site 1041826005744 trigger factor interaction site; other site 1041826005745 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1041826005746 23S rRNA interface [nucleotide binding]; other site 1041826005747 5S rRNA interface [nucleotide binding]; other site 1041826005748 putative antibiotic binding site [chemical binding]; other site 1041826005749 L25 interface [polypeptide binding]; other site 1041826005750 L27 interface [polypeptide binding]; other site 1041826005751 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1041826005752 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1041826005753 G-X-X-G motif; other site 1041826005754 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1041826005755 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1041826005756 putative translocon binding site; other site 1041826005757 protein-rRNA interface [nucleotide binding]; other site 1041826005758 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1041826005759 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1041826005760 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1041826005761 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1041826005762 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1041826005763 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1041826005764 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1041826005765 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1041826005766 elongation factor G; Reviewed; Region: PRK12739 1041826005767 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1041826005768 G1 box; other site 1041826005769 putative GEF interaction site [polypeptide binding]; other site 1041826005770 GTP/Mg2+ binding site [chemical binding]; other site 1041826005771 Switch I region; other site 1041826005772 G2 box; other site 1041826005773 G3 box; other site 1041826005774 Switch II region; other site 1041826005775 G4 box; other site 1041826005776 G5 box; other site 1041826005777 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1041826005778 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1041826005779 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1041826005780 30S ribosomal protein S7; Validated; Region: PRK05302 1041826005781 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1041826005782 S17 interaction site [polypeptide binding]; other site 1041826005783 S8 interaction site; other site 1041826005784 16S rRNA interaction site [nucleotide binding]; other site 1041826005785 streptomycin interaction site [chemical binding]; other site 1041826005786 23S rRNA interaction site [nucleotide binding]; other site 1041826005787 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1041826005788 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 1041826005789 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 1041826005790 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826005791 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1041826005792 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826005793 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 1041826005794 starch binding outer membrane protein SusD; Region: SusD; cl17845 1041826005795 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1041826005796 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1041826005797 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1041826005798 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1041826005799 recombination factor protein RarA; Reviewed; Region: PRK13342 1041826005800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826005801 Walker A motif; other site 1041826005802 ATP binding site [chemical binding]; other site 1041826005803 Walker B motif; other site 1041826005804 arginine finger; other site 1041826005805 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1041826005806 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1041826005807 active site 1041826005808 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1041826005809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041826005810 motif II; other site 1041826005811 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1041826005812 FtsX-like permease family; Region: FtsX; pfam02687 1041826005813 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1041826005814 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041826005815 Walker A/P-loop; other site 1041826005816 ATP binding site [chemical binding]; other site 1041826005817 Q-loop/lid; other site 1041826005818 ABC transporter signature motif; other site 1041826005819 Walker B; other site 1041826005820 D-loop; other site 1041826005821 H-loop/switch region; other site 1041826005822 hypothetical protein; Reviewed; Region: PRK00024 1041826005823 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1041826005824 MPN+ (JAMM) motif; other site 1041826005825 Zinc-binding site [ion binding]; other site 1041826005826 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1041826005827 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1041826005828 N-terminal plug; other site 1041826005829 ligand-binding site [chemical binding]; other site 1041826005830 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1041826005831 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1041826005832 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1041826005833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1041826005834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1041826005835 DNA binding residues [nucleotide binding] 1041826005836 dimerization interface [polypeptide binding]; other site 1041826005837 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1041826005838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826005839 catalytic residue [active] 1041826005840 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1041826005841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041826005842 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1041826005843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1041826005844 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1041826005845 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1041826005846 IucA / IucC family; Region: IucA_IucC; pfam04183 1041826005847 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1041826005848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1041826005849 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1041826005850 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1041826005851 IucA / IucC family; Region: IucA_IucC; pfam04183 1041826005852 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1041826005853 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 1041826005854 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1041826005855 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 1041826005856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1041826005857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1041826005858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1041826005859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1041826005860 binding surface 1041826005861 TPR motif; other site 1041826005862 Peptidase S46; Region: Peptidase_S46; pfam10459 1041826005863 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041826005864 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1041826005865 catalytic residues [active] 1041826005866 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1041826005867 Ribosome inactivating protein; Region: RIP; pfam00161 1041826005868 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1041826005869 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 1041826005870 Peptidase family M28; Region: Peptidase_M28; pfam04389 1041826005871 metal binding site [ion binding]; metal-binding site 1041826005872 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1041826005873 active site 1041826005874 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826005875 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1041826005876 GTP1/OBG; Region: GTP1_OBG; pfam01018 1041826005877 Obg GTPase; Region: Obg; cd01898 1041826005878 G1 box; other site 1041826005879 GTP/Mg2+ binding site [chemical binding]; other site 1041826005880 Switch I region; other site 1041826005881 G2 box; other site 1041826005882 G3 box; other site 1041826005883 Switch II region; other site 1041826005884 G4 box; other site 1041826005885 G5 box; other site 1041826005886 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1041826005887 Domain of unknown function DUF21; Region: DUF21; pfam01595 1041826005888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1041826005889 Transporter associated domain; Region: CorC_HlyC; smart01091 1041826005890 adenylate kinase; Reviewed; Region: adk; PRK00279 1041826005891 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1041826005892 AMP-binding site [chemical binding]; other site 1041826005893 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1041826005894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826005895 active site 1041826005896 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1041826005897 ATP-grasp domain; Region: ATP-grasp; pfam02222 1041826005898 AAA domain; Region: AAA_21; pfam13304 1041826005899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826005900 Walker B; other site 1041826005901 D-loop; other site 1041826005902 H-loop/switch region; other site 1041826005903 TIGR02646 family protein; Region: TIGR02646 1041826005904 AIR carboxylase; Region: AIRC; pfam00731 1041826005905 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1041826005906 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1041826005907 active site 1041826005908 Zn binding site [ion binding]; other site 1041826005909 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1041826005910 putative active site [active] 1041826005911 Predicted transcriptional regulators [Transcription]; Region: COG1510 1041826005912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041826005913 dimerization interface [polypeptide binding]; other site 1041826005914 putative DNA binding site [nucleotide binding]; other site 1041826005915 putative Zn2+ binding site [ion binding]; other site 1041826005916 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1041826005917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826005918 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1041826005919 NAD(P) binding site [chemical binding]; other site 1041826005920 active site 1041826005921 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1041826005922 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1041826005923 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1041826005924 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1041826005925 Transglycosylase; Region: Transgly; pfam00912 1041826005926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1041826005927 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1041826005928 MG2 domain; Region: A2M_N; pfam01835 1041826005929 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1041826005930 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1041826005931 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1041826005932 surface patch; other site 1041826005933 thioester region; other site 1041826005934 specificity defining residues; other site 1041826005935 glycine dehydrogenase; Provisional; Region: PRK05367 1041826005936 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1041826005937 tetramer interface [polypeptide binding]; other site 1041826005938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826005939 catalytic residue [active] 1041826005940 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1041826005941 tetramer interface [polypeptide binding]; other site 1041826005942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826005943 catalytic residue [active] 1041826005944 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1041826005945 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1041826005946 dimer interface [polypeptide binding]; other site 1041826005947 active site 1041826005948 CoA binding pocket [chemical binding]; other site 1041826005949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826005950 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1041826005951 substrate binding site [chemical binding]; other site 1041826005952 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1041826005953 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1041826005954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1041826005955 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1041826005956 Beta-lactamase; Region: Beta-lactamase; pfam00144 1041826005957 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 1041826005958 active site 1041826005959 ligand binding site [chemical binding]; other site 1041826005960 NAD(P) binding site [chemical binding]; other site 1041826005961 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1041826005962 HSP70 interaction site [polypeptide binding]; other site 1041826005963 KTSC domain; Region: KTSC; pfam13619 1041826005964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1041826005965 sequence-specific DNA binding site [nucleotide binding]; other site 1041826005966 salt bridge; other site 1041826005967 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1041826005968 MPN+ (JAMM) motif; other site 1041826005969 Zinc-binding site [ion binding]; other site 1041826005970 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 1041826005971 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1041826005972 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826005973 ATP binding site [chemical binding]; other site 1041826005974 putative Mg++ binding site [ion binding]; other site 1041826005975 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1041826005976 Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987 1041826005977 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1041826005978 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1041826005979 Walker A motif; other site 1041826005980 ATP binding site [chemical binding]; other site 1041826005981 Walker B motif; other site 1041826005982 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826005983 active site 1041826005984 Int/Topo IB signature motif; other site 1041826005985 DNA binding site [nucleotide binding] 1041826005986 potential frameshift: common BLAST hit: gi|325286666|ref|YP_004262456.1| Histidine decarboxylase 1041826005987 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1041826005988 FAD binding domain; Region: FAD_binding_4; pfam01565 1041826005989 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1041826005990 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1041826005991 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1041826005992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1041826005993 motif II; other site 1041826005994 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1041826005995 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1041826005996 ligand binding site [chemical binding]; other site 1041826005997 NAD binding site [chemical binding]; other site 1041826005998 tetramer interface [polypeptide binding]; other site 1041826005999 catalytic site [active] 1041826006000 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1041826006001 L-serine binding site [chemical binding]; other site 1041826006002 ACT domain interface; other site 1041826006003 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1041826006004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1041826006005 putative DNA binding site [nucleotide binding]; other site 1041826006006 putative Zn2+ binding site [ion binding]; other site 1041826006007 AsnC family; Region: AsnC_trans_reg; pfam01037 1041826006008 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826006009 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826006010 Right handed beta helix region; Region: Beta_helix; pfam13229 1041826006011 Disaggregatase related; Region: Disaggr_assoc; pfam08480 1041826006012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1041826006013 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1041826006014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826006015 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826006016 ABC transporter; Region: ABC_tran_2; pfam12848 1041826006017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826006018 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 1041826006019 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1041826006020 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1041826006021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041826006022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006023 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1041826006024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1041826006025 gliding motility associated protien GldN; Region: GldN; TIGR03523 1041826006026 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 1041826006027 GldM N-terminal domain; Region: GldM_N; pfam12081 1041826006028 GldM C-terminal domain; Region: GldM_C; pfam12080 1041826006029 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 1041826006030 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 1041826006031 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 1041826006032 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1041826006033 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1041826006034 putative active site [active] 1041826006035 putative metal binding site [ion binding]; other site 1041826006036 DNA topoisomerase I; Validated; Region: PRK05582 1041826006037 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1041826006038 active site 1041826006039 interdomain interaction site; other site 1041826006040 putative metal-binding site [ion binding]; other site 1041826006041 nucleotide binding site [chemical binding]; other site 1041826006042 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1041826006043 domain I; other site 1041826006044 DNA binding groove [nucleotide binding] 1041826006045 phosphate binding site [ion binding]; other site 1041826006046 domain II; other site 1041826006047 domain III; other site 1041826006048 nucleotide binding site [chemical binding]; other site 1041826006049 catalytic site [active] 1041826006050 domain IV; other site 1041826006051 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 1041826006052 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1041826006053 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1041826006054 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 1041826006055 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1041826006056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1041826006057 FeS/SAM binding site; other site 1041826006058 TRAM domain; Region: TRAM; pfam01938 1041826006059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826006060 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1041826006061 Walker A motif; other site 1041826006062 ATP binding site [chemical binding]; other site 1041826006063 Walker B motif; other site 1041826006064 arginine finger; other site 1041826006065 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1041826006066 Lipopolysaccharide-assembly; Region: LptE; cl01125 1041826006067 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1041826006068 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1041826006069 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1041826006070 oligomerisation interface [polypeptide binding]; other site 1041826006071 mobile loop; other site 1041826006072 roof hairpin; other site 1041826006073 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1041826006074 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1041826006075 ring oligomerisation interface [polypeptide binding]; other site 1041826006076 ATP/Mg binding site [chemical binding]; other site 1041826006077 stacking interactions; other site 1041826006078 hinge regions; other site 1041826006079 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1041826006080 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1041826006081 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1041826006082 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1041826006083 putative active site pocket [active] 1041826006084 dimerization interface [polypeptide binding]; other site 1041826006085 putative catalytic residue [active] 1041826006086 Domain of unknown function (DUF2024); Region: DUF2024; pfam09630 1041826006087 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 1041826006088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826006089 short chain dehydrogenase; Provisional; Region: PRK05993 1041826006090 NAD(P) binding site [chemical binding]; other site 1041826006091 active site 1041826006092 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1041826006093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1041826006094 acyl-activating enzyme (AAE) consensus motif; other site 1041826006095 AMP binding site [chemical binding]; other site 1041826006096 active site 1041826006097 CoA binding site [chemical binding]; other site 1041826006098 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1041826006099 active site 1041826006100 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1041826006101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1041826006102 TPR motif; other site 1041826006103 binding surface 1041826006104 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1041826006105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1041826006106 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826006107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1041826006108 putative acyl-acceptor binding pocket; other site 1041826006109 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1041826006110 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1041826006111 Ligand binding site; other site 1041826006112 Putative Catalytic site; other site 1041826006113 DXD motif; other site 1041826006114 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1041826006115 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1041826006116 active site 2 [active] 1041826006117 dimer interface [polypeptide binding]; other site 1041826006118 active site 1 [active] 1041826006119 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 1041826006120 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1041826006121 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1041826006122 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1041826006123 NodB motif; other site 1041826006124 active site 1041826006125 catalytic site [active] 1041826006126 metal binding site [ion binding]; metal-binding site 1041826006127 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1041826006128 active site 1041826006129 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1041826006130 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1041826006131 dimer interface [polypeptide binding]; other site 1041826006132 active site 1041826006133 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1041826006134 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1041826006135 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1041826006136 dimer interface [polypeptide binding]; other site 1041826006137 active site 1041826006138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1041826006139 active site 1041826006140 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1041826006141 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1041826006142 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1041826006143 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1041826006144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826006145 Walker A/P-loop; other site 1041826006146 ATP binding site [chemical binding]; other site 1041826006147 Q-loop/lid; other site 1041826006148 ABC transporter signature motif; other site 1041826006149 Walker B; other site 1041826006150 D-loop; other site 1041826006151 H-loop/switch region; other site 1041826006152 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1041826006153 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1041826006154 active site 1 [active] 1041826006155 active site 2 [active] 1041826006156 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1041826006157 active site 1 [active] 1041826006158 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 1041826006159 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1041826006160 dimer interface [polypeptide binding]; other site 1041826006161 active site 1041826006162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1041826006163 putative acyl-acceptor binding pocket; other site 1041826006164 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1041826006165 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1041826006166 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1041826006167 dimer interface [polypeptide binding]; other site 1041826006168 active site 1041826006169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826006170 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1041826006171 NAD(P) binding site [chemical binding]; other site 1041826006172 active site 1041826006173 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1041826006174 active sites [active] 1041826006175 tetramer interface [polypeptide binding]; other site 1041826006176 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1041826006177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1041826006178 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1041826006179 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1041826006180 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1041826006181 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1041826006182 HlyD family secretion protein; Region: HlyD_3; pfam13437 1041826006183 Outer membrane efflux protein; Region: OEP; pfam02321 1041826006184 Outer membrane efflux protein; Region: OEP; pfam02321 1041826006185 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1041826006186 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1041826006187 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1041826006188 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1041826006189 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1041826006190 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1041826006191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1041826006192 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1041826006193 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1041826006194 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1041826006195 active site clefts [active] 1041826006196 zinc binding site [ion binding]; other site 1041826006197 dimer interface [polypeptide binding]; other site 1041826006198 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826006199 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826006200 Fic family protein [Function unknown]; Region: COG3177 1041826006201 Fic/DOC family; Region: Fic; pfam02661 1041826006202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1041826006203 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1041826006204 ATP binding site [chemical binding]; other site 1041826006205 putative Mg++ binding site [ion binding]; other site 1041826006206 Response regulator receiver domain; Region: Response_reg; pfam00072 1041826006207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1041826006208 active site 1041826006209 phosphorylation site [posttranslational modification] 1041826006210 intermolecular recognition site; other site 1041826006211 dimerization interface [polypeptide binding]; other site 1041826006212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1041826006213 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1041826006214 Walker A motif; other site 1041826006215 ATP binding site [chemical binding]; other site 1041826006216 Walker B motif; other site 1041826006217 arginine finger; other site 1041826006218 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1041826006219 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1041826006220 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1041826006221 Walker A/P-loop; other site 1041826006222 ATP binding site [chemical binding]; other site 1041826006223 Q-loop/lid; other site 1041826006224 ABC transporter signature motif; other site 1041826006225 Walker B; other site 1041826006226 D-loop; other site 1041826006227 H-loop/switch region; other site 1041826006228 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1041826006229 chaperone protein DnaJ; Provisional; Region: PRK14289 1041826006230 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1041826006231 HSP70 interaction site [polypeptide binding]; other site 1041826006232 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1041826006233 substrate binding site [polypeptide binding]; other site 1041826006234 dimer interface [polypeptide binding]; other site 1041826006235 GrpE; Region: GrpE; pfam01025 1041826006236 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1041826006237 dimer interface [polypeptide binding]; other site 1041826006238 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1041826006239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826006240 TIGR01777 family protein; Region: yfcH 1041826006241 NAD(P) binding site [chemical binding]; other site 1041826006242 active site 1041826006243 Tic20-like protein; Region: Tic20; pfam09685 1041826006244 Predicted transcriptional regulators [Transcription]; Region: COG1695 1041826006245 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1041826006246 PspC domain; Region: PspC; pfam04024 1041826006247 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1041826006248 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1041826006249 Bacterial proteins similar to Porphyromonas gingivalis HmuY and the C-terminal domain of PARMER_03218; Region: HmuY_like; cl12009 1041826006250 Bacterial proteins similar to Porphyromonas gingivalis HmuY and the C-terminal domain of PARMER_03218; Region: HmuY_like; cl12009 1041826006251 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826006252 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 1041826006253 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826006254 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826006255 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1041826006256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1041826006257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1041826006258 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1041826006259 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1041826006260 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041826006261 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 1041826006262 ribosomal protein L33; Region: rpl33; CHL00104 1041826006263 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1041826006264 competence damage-inducible protein A; Provisional; Region: PRK00549 1041826006265 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1041826006266 putative MPT binding site; other site 1041826006267 Competence-damaged protein; Region: CinA; pfam02464 1041826006268 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1041826006269 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1041826006270 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1041826006271 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1041826006272 active site 1041826006273 catalytic site [active] 1041826006274 substrate binding site [chemical binding]; other site 1041826006275 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1041826006276 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1041826006277 E3 interaction surface; other site 1041826006278 lipoyl attachment site [posttranslational modification]; other site 1041826006279 e3 binding domain; Region: E3_binding; pfam02817 1041826006280 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1041826006281 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1041826006282 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1041826006283 Probable Catalytic site; other site 1041826006284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826006285 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1041826006286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826006287 Walker A/P-loop; other site 1041826006288 ATP binding site [chemical binding]; other site 1041826006289 Q-loop/lid; other site 1041826006290 ABC transporter signature motif; other site 1041826006291 Walker B; other site 1041826006292 D-loop; other site 1041826006293 H-loop/switch region; other site 1041826006294 ABC transporter; Region: ABC_tran_2; pfam12848 1041826006295 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1041826006296 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1041826006297 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1041826006298 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826006299 catalytic residues [active] 1041826006300 Outer membrane protein Omp28; Region: Omp28; pfam11551 1041826006301 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1041826006302 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1041826006303 Walker A/P-loop; other site 1041826006304 ATP binding site [chemical binding]; other site 1041826006305 Q-loop/lid; other site 1041826006306 ABC transporter signature motif; other site 1041826006307 Walker B; other site 1041826006308 D-loop; other site 1041826006309 H-loop/switch region; other site 1041826006310 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041826006311 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1041826006312 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041826006313 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1041826006314 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1041826006315 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1041826006316 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1041826006317 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 1041826006318 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1041826006319 nucleotide binding region [chemical binding]; other site 1041826006320 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1041826006321 ATP-binding site [chemical binding]; other site 1041826006322 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1041826006323 DinB superfamily; Region: DinB_2; pfam12867 1041826006324 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1041826006325 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1041826006326 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1041826006327 methionine aminotransferase; Validated; Region: PRK09082 1041826006328 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1041826006329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826006330 homodimer interface [polypeptide binding]; other site 1041826006331 catalytic residue [active] 1041826006332 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1041826006333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1041826006334 P-loop; other site 1041826006335 Magnesium ion binding site [ion binding]; other site 1041826006336 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1041826006337 Magnesium ion binding site [ion binding]; other site 1041826006338 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1041826006339 ParB-like nuclease domain; Region: ParBc; pfam02195 1041826006340 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1041826006341 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1041826006342 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1041826006343 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1041826006344 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1041826006345 Catalytic site [active] 1041826006346 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1041826006347 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1041826006348 WbqC-like protein family; Region: WbqC; pfam08889 1041826006349 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 1041826006350 putative catalytic site [active] 1041826006351 putative metal binding site [ion binding]; other site 1041826006352 putative phosphate binding site [ion binding]; other site 1041826006353 Rhomboid family; Region: Rhomboid; pfam01694 1041826006354 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1041826006355 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1041826006356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1041826006357 ATP binding site [chemical binding]; other site 1041826006358 Mg2+ binding site [ion binding]; other site 1041826006359 G-X-G motif; other site 1041826006360 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1041826006361 ATP binding site [chemical binding]; other site 1041826006362 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 1041826006363 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1041826006364 homopentamer interface [polypeptide binding]; other site 1041826006365 active site 1041826006366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826006367 binding surface 1041826006368 TPR motif; other site 1041826006369 recombination protein F; Reviewed; Region: recF; PRK00064 1041826006370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826006371 Walker A/P-loop; other site 1041826006372 ATP binding site [chemical binding]; other site 1041826006373 Q-loop/lid; other site 1041826006374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1041826006375 ABC transporter signature motif; other site 1041826006376 Walker B; other site 1041826006377 D-loop; other site 1041826006378 H-loop/switch region; other site 1041826006379 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1041826006380 active site residue [active] 1041826006381 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1041826006382 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1041826006383 catalytic residues [active] 1041826006384 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1041826006385 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1041826006386 FAD binding domain; Region: FAD_binding_4; pfam01565 1041826006387 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1041826006388 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1041826006389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826006390 active site 1041826006391 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1041826006392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1041826006393 DNA binding residues [nucleotide binding] 1041826006394 potential frameshift: common BLAST hit: gi|347537248|ref|YP_004844673.1| transposase IS1182 family 1041826006395 Transposase domain (DUF772); Region: DUF772; pfam05598 1041826006396 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1041826006397 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 1041826006398 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 1041826006399 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1041826006400 Predicted transporter component [General function prediction only]; Region: COG2391 1041826006401 Sulphur transport; Region: Sulf_transp; pfam04143 1041826006402 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1041826006403 Cytochrome c; Region: Cytochrom_C; cl11414 1041826006404 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1041826006405 active site 1041826006406 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1041826006407 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1041826006408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1041826006409 Coenzyme A binding pocket [chemical binding]; other site 1041826006410 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1041826006411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1041826006412 S-adenosylmethionine binding site [chemical binding]; other site 1041826006413 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 1041826006414 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1041826006415 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1041826006416 human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; Region: 17beta-HSDXI-like_SDR_c; cd05339 1041826006417 putative NAD(P) binding site [chemical binding]; other site 1041826006418 homodimer interface [polypeptide binding]; other site 1041826006419 active site 1041826006420 substrate binding site [chemical binding]; other site 1041826006421 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1041826006422 Superinfection exclusion protein B; Region: SieB; pfam14163 1041826006423 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1041826006424 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1041826006425 integron integrase; Region: integrase_gron; TIGR02249 1041826006426 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1041826006427 active site 1041826006428 Int/Topo IB signature motif; other site 1041826006429 DNA binding site [nucleotide binding] 1041826006430 putative methyltransferase; Provisional; Region: PRK11524 1041826006431 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1041826006432 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1041826006433 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1041826006434 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1041826006435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006436 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1041826006437 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1041826006438 homodimer interface [polypeptide binding]; other site 1041826006439 substrate-cofactor binding pocket; other site 1041826006440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826006441 catalytic residue [active] 1041826006442 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1041826006443 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1041826006444 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1041826006445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1041826006446 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1041826006447 catalytic residue [active] 1041826006448 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1041826006449 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1041826006450 inhibitor-cofactor binding pocket; inhibition site 1041826006451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826006452 catalytic residue [active] 1041826006453 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1041826006454 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1041826006455 NAD(P) binding site [chemical binding]; other site 1041826006456 homodimer interface [polypeptide binding]; other site 1041826006457 substrate binding site [chemical binding]; other site 1041826006458 active site 1041826006459 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1041826006460 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1041826006461 tyrosine kinase; Provisional; Region: PRK11519 1041826006462 Chain length determinant protein; Region: Wzz; pfam02706 1041826006463 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1041826006464 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1041826006465 potential frameshift: common BLAST hit: gi|326796984|ref|YP_004314804.1| transposase mutator type 1041826006466 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1041826006467 DNA-binding interface [nucleotide binding]; DNA binding site 1041826006468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1041826006469 HTH-like domain; Region: HTH_21; pfam13276 1041826006470 Integrase core domain; Region: rve; pfam00665 1041826006471 Integrase core domain; Region: rve_3; pfam13683 1041826006472 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1041826006473 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1041826006474 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1041826006475 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1041826006476 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1041826006477 Walker A/P-loop; other site 1041826006478 ATP binding site [chemical binding]; other site 1041826006479 Q-loop/lid; other site 1041826006480 ABC transporter signature motif; other site 1041826006481 Walker B; other site 1041826006482 D-loop; other site 1041826006483 H-loop/switch region; other site 1041826006484 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1041826006485 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1041826006486 active site 1041826006487 homodimer interface [polypeptide binding]; other site 1041826006488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1041826006489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826006490 NAD(P) binding site [chemical binding]; other site 1041826006491 active site 1041826006492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041826006493 active site 1041826006494 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1041826006495 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1041826006496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006497 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1041826006498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006499 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1041826006500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1041826006501 active site 1041826006502 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1041826006503 potential frameshift: common BLAST hit: gi|332292705|ref|YP_004431314.1| 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 1041826006504 NeuB family; Region: NeuB; pfam03102 1041826006505 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1041826006506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006507 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1041826006508 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1041826006509 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041826006510 active site 1041826006511 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1041826006512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1041826006513 active site 1041826006514 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1041826006515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006516 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1041826006517 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1041826006518 putative ADP-binding pocket [chemical binding]; other site 1041826006519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006520 O-Antigen ligase; Region: Wzy_C; pfam04932 1041826006521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1041826006522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1041826006523 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1041826006524 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1041826006525 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1041826006526 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1041826006527 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1041826006528 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1041826006529 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 1041826006530 active site 1041826006531 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1041826006532 active site 1041826006533 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1041826006534 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1041826006535 N-terminal plug; other site 1041826006536 ligand-binding site [chemical binding]; other site 1041826006537 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1041826006538 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1041826006539 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1041826006540 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1041826006541 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1041826006542 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1041826006543 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1041826006544 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1041826006545 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1041826006546 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1041826006547 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1041826006548 Flavodoxin; Region: Flavodoxin_1; pfam00258 1041826006549 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1041826006550 FAD binding pocket [chemical binding]; other site 1041826006551 conserved FAD binding motif [chemical binding]; other site 1041826006552 phosphate binding motif [ion binding]; other site 1041826006553 beta-alpha-beta structure motif; other site 1041826006554 NAD binding pocket [chemical binding]; other site 1041826006555 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1041826006556 ApbE family; Region: ApbE; pfam02424 1041826006557 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1041826006558 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1041826006559 Walker A/P-loop; other site 1041826006560 ATP binding site [chemical binding]; other site 1041826006561 Q-loop/lid; other site 1041826006562 ABC transporter signature motif; other site 1041826006563 Walker B; other site 1041826006564 D-loop; other site 1041826006565 H-loop/switch region; other site 1041826006566 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1041826006567 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1041826006568 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1041826006569 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1041826006570 putative active site [active] 1041826006571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1041826006572 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1041826006573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826006574 ATP binding site [chemical binding]; other site 1041826006575 putative Mg++ binding site [ion binding]; other site 1041826006576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1041826006577 nucleotide binding region [chemical binding]; other site 1041826006578 ATP-binding site [chemical binding]; other site 1041826006579 RQC domain; Region: RQC; pfam09382 1041826006580 HRDC domain; Region: HRDC; pfam00570 1041826006581 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1041826006582 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1041826006583 DNA-binding interface [nucleotide binding]; DNA binding site 1041826006584 putative transposase OrfB; Reviewed; Region: PHA02517 1041826006585 HTH-like domain; Region: HTH_21; pfam13276 1041826006586 Integrase core domain; Region: rve; pfam00665 1041826006587 Integrase core domain; Region: rve_3; pfam13683 1041826006588 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826006589 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 1041826006590 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1041826006591 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1041826006592 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1041826006593 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1041826006594 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1041826006595 active site 1041826006596 RecX family; Region: RecX; pfam02631 1041826006597 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826006598 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1041826006599 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1041826006600 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826006601 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1041826006602 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1041826006603 catalytic triad [active] 1041826006604 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1041826006605 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1041826006606 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1041826006607 alpha subunit interaction interface [polypeptide binding]; other site 1041826006608 Walker A motif; other site 1041826006609 ATP binding site [chemical binding]; other site 1041826006610 Walker B motif; other site 1041826006611 inhibitor binding site; inhibition site 1041826006612 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1041826006613 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1041826006614 gamma subunit interface [polypeptide binding]; other site 1041826006615 LBP interface [polypeptide binding]; other site 1041826006616 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1041826006617 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1041826006618 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826006619 catalytic residue [active] 1041826006620 PIF1-like helicase; Region: PIF1; pfam05970 1041826006621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1041826006622 ATP binding site [chemical binding]; other site 1041826006623 putative Mg++ binding site [ion binding]; other site 1041826006624 Family description; Region: UvrD_C_2; pfam13538 1041826006625 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1041826006626 ArsC family; Region: ArsC; pfam03960 1041826006627 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1041826006628 EamA-like transporter family; Region: EamA; pfam00892 1041826006629 EamA-like transporter family; Region: EamA; pfam00892 1041826006630 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1041826006631 hypothetical protein; Provisional; Region: PRK11820 1041826006632 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1041826006633 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1041826006634 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1041826006635 four helix bundle protein; Region: TIGR02436 1041826006636 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1041826006637 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1041826006638 catalytic site [active] 1041826006639 G-X2-G-X-G-K; other site 1041826006640 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1041826006641 four helix bundle protein; Region: TIGR02436 1041826006642 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1041826006643 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1041826006644 active site 1041826006645 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1041826006646 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1041826006647 amidase catalytic site [active] 1041826006648 Zn binding residues [ion binding]; other site 1041826006649 substrate binding site [chemical binding]; other site 1041826006650 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1041826006651 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1041826006652 active site 1041826006653 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1041826006654 active site 1041826006655 metal binding site [ion binding]; metal-binding site 1041826006656 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1041826006657 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 1041826006658 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1041826006659 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1041826006660 putative ADP-ribose binding site [chemical binding]; other site 1041826006661 putative active site [active] 1041826006662 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1041826006663 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1041826006664 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1041826006665 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1041826006666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826006667 active site 1041826006668 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1041826006669 nudix motif; other site 1041826006670 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1041826006671 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1041826006672 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1041826006673 dimer interface [polypeptide binding]; other site 1041826006674 active site 1041826006675 metal binding site [ion binding]; metal-binding site 1041826006676 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 1041826006677 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1041826006678 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1041826006679 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1041826006680 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1041826006681 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1041826006682 dimer interface [polypeptide binding]; other site 1041826006683 motif 1; other site 1041826006684 active site 1041826006685 motif 2; other site 1041826006686 motif 3; other site 1041826006687 Colicin V production protein; Region: Colicin_V; pfam02674 1041826006688 FeS assembly protein SufD; Region: sufD; TIGR01981 1041826006689 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1041826006690 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 1041826006691 four helix bundle protein; Region: TIGR02436 1041826006692 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1041826006693 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1041826006694 Walker A/P-loop; other site 1041826006695 ATP binding site [chemical binding]; other site 1041826006696 Q-loop/lid; other site 1041826006697 ABC transporter signature motif; other site 1041826006698 Walker B; other site 1041826006699 D-loop; other site 1041826006700 H-loop/switch region; other site 1041826006701 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1041826006702 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1041826006703 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1041826006704 putative ABC transporter; Region: ycf24; CHL00085 1041826006705 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1041826006706 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1041826006707 Peptidase family M48; Region: Peptidase_M48; pfam01435 1041826006708 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1041826006709 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1041826006710 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 1041826006711 active site 1041826006712 catalytic triad [active] 1041826006713 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1041826006714 Zn binding site [ion binding]; other site 1041826006715 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1041826006716 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1041826006717 active site 1041826006718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1041826006719 active site 1041826006720 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1041826006721 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1041826006722 substrate binding site [chemical binding]; other site 1041826006723 ATP binding site [chemical binding]; other site 1041826006724 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1041826006725 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1041826006726 HflX GTPase family; Region: HflX; cd01878 1041826006727 G1 box; other site 1041826006728 GTP/Mg2+ binding site [chemical binding]; other site 1041826006729 Switch I region; other site 1041826006730 G2 box; other site 1041826006731 G3 box; other site 1041826006732 Switch II region; other site 1041826006733 G4 box; other site 1041826006734 G5 box; other site 1041826006735 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1041826006736 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1041826006737 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1041826006738 putative catalytic site [active] 1041826006739 putative metal binding site [ion binding]; other site 1041826006740 putative phosphate binding site [ion binding]; other site 1041826006741 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 1041826006742 aldehyde dehydrogenase family 7 member; Region: PLN02315 1041826006743 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1041826006744 tetrameric interface [polypeptide binding]; other site 1041826006745 NAD binding site [chemical binding]; other site 1041826006746 catalytic residues [active] 1041826006747 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1041826006748 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1041826006749 homodimer interface [polypeptide binding]; other site 1041826006750 substrate-cofactor binding pocket; other site 1041826006751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826006752 catalytic residue [active] 1041826006753 glutamate dehydrogenase; Provisional; Region: PRK09414 1041826006754 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1041826006755 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1041826006756 NAD(P) binding site [chemical binding]; other site 1041826006757 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1041826006758 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1041826006759 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1041826006760 Recombination protein O N terminal; Region: RecO_N; pfam11967 1041826006761 Recombination protein O C terminal; Region: RecO_C; pfam02565 1041826006762 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1041826006763 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826006764 active site 1041826006765 HIGH motif; other site 1041826006766 nucleotide binding site [chemical binding]; other site 1041826006767 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826006768 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1041826006769 active site 1041826006770 KMSKS motif; other site 1041826006771 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1041826006772 tRNA binding surface [nucleotide binding]; other site 1041826006773 anticodon binding site; other site 1041826006774 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1041826006775 lipoprotein signal peptidase; Provisional; Region: PRK14788 1041826006776 lipoprotein signal peptidase; Provisional; Region: PRK14787 1041826006777 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1041826006778 RNA/DNA hybrid binding site [nucleotide binding]; other site 1041826006779 active site 1041826006780 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1041826006781 active site 1041826006782 substrate binding site [chemical binding]; other site 1041826006783 cosubstrate binding site; other site 1041826006784 catalytic site [active] 1041826006785 acyl carrier protein; Provisional; Region: acpP; PRK00982 1041826006786 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1041826006787 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1041826006788 dimer interface [polypeptide binding]; other site 1041826006789 active site 1041826006790 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1041826006791 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1041826006792 dimerization interface [polypeptide binding]; other site 1041826006793 active site 1041826006794 metal binding site [ion binding]; metal-binding site 1041826006795 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1041826006796 dsRNA binding site [nucleotide binding]; other site 1041826006797 Divergent AAA domain; Region: AAA_4; pfam04326 1041826006798 MoxR-like ATPases [General function prediction only]; Region: COG0714 1041826006799 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1041826006800 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1041826006801 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1041826006802 metal ion-dependent adhesion site (MIDAS); other site 1041826006803 four helix bundle protein; Region: TIGR02436 1041826006804 Oxygen tolerance; Region: BatD; pfam13584 1041826006805 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1041826006806 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1041826006807 metal ion-dependent adhesion site (MIDAS); other site 1041826006808 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1041826006809 metal ion-dependent adhesion site (MIDAS); other site 1041826006810 TPR repeat; Region: TPR_11; pfam13414 1041826006811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826006812 binding surface 1041826006813 Oxygen tolerance; Region: BatD; pfam13584 1041826006814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1041826006815 binding surface 1041826006816 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1041826006817 TPR motif; other site 1041826006818 Bacterial SH3 domain; Region: SH3_3; cl17532 1041826006819 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1041826006820 Beta-lactamase; Region: Beta-lactamase; pfam00144 1041826006821 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1041826006822 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1041826006823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1041826006824 catalytic residue [active] 1041826006825 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1041826006826 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1041826006827 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1041826006828 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 1041826006829 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 1041826006830 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1041826006831 AAA domain; Region: AAA_26; pfam13500 1041826006832 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1041826006833 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1041826006834 inhibitor-cofactor binding pocket; inhibition site 1041826006835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1041826006836 catalytic residue [active] 1041826006837 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1041826006838 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1041826006839 domain interfaces; other site 1041826006840 active site 1041826006841 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1041826006842 active site 1041826006843 DNA polymerase IV; Validated; Region: PRK02406 1041826006844 DNA binding site [nucleotide binding] 1041826006845 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1041826006846 putative active site [active] 1041826006847 putative metal binding residues [ion binding]; other site 1041826006848 signature motif; other site 1041826006849 putative dimer interface [polypeptide binding]; other site 1041826006850 putative phosphate binding site [ion binding]; other site 1041826006851 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1041826006852 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1041826006853 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1041826006854 putative acyl-acceptor binding pocket; other site 1041826006855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1041826006856 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1041826006857 putative active site [active] 1041826006858 putative catalytic site [active] 1041826006859 putative DNA binding site [nucleotide binding]; other site 1041826006860 putative phosphate binding site [ion binding]; other site 1041826006861 metal binding site A [ion binding]; metal-binding site 1041826006862 putative AP binding site [nucleotide binding]; other site 1041826006863 putative metal binding site B [ion binding]; other site 1041826006864 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1041826006865 ligand binding site [chemical binding]; other site 1041826006866 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1041826006867 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1041826006868 active site 1041826006869 catalytic tetrad [active] 1041826006870 conserved hypothetical protein; Region: TIGR02231 1041826006871 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1041826006872 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1041826006873 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1041826006874 Transglycosylase; Region: Transgly; pfam00912 1041826006875 DNA repair protein RadA; Provisional; Region: PRK11823 1041826006876 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1041826006877 Walker A motif/ATP binding site; other site 1041826006878 ATP binding site [chemical binding]; other site 1041826006879 Walker B motif; other site 1041826006880 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1041826006881 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1041826006882 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1041826006883 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1041826006884 tetramerization interface [polypeptide binding]; other site 1041826006885 active site 1041826006886 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1041826006887 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1041826006888 active site 1041826006889 ATP-binding site [chemical binding]; other site 1041826006890 pantoate-binding site; other site 1041826006891 HXXH motif; other site 1041826006892 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 1041826006893 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 1041826006894 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1041826006895 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1041826006896 glutaminase active site [active] 1041826006897 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1041826006898 dimer interface [polypeptide binding]; other site 1041826006899 active site 1041826006900 14-3-3 domain; Region: 14-3-3; cl02098 1041826006901 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1041826006902 dimer interface [polypeptide binding]; other site 1041826006903 active site 1041826006904 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1041826006905 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1041826006906 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 1041826006907 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1041826006908 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1041826006909 Interdomain contacts; other site 1041826006910 Cytokine receptor motif; other site 1041826006911 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 1041826006912 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1041826006913 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1041826006914 active site 1041826006915 HIGH motif; other site 1041826006916 dimer interface [polypeptide binding]; other site 1041826006917 KMSKS motif; other site 1041826006918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1041826006919 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1041826006920 NAD(P) binding site [chemical binding]; other site 1041826006921 active site 1041826006922 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 1041826006923 dihydroorotase; Reviewed; Region: PRK09236 1041826006924 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1041826006925 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1041826006926 active site 1041826006927 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1041826006928 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1041826006929 Ligand binding site; other site 1041826006930 Putative Catalytic site; other site 1041826006931 DXD motif; other site 1041826006932 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 1041826006933 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1041826006934 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1041826006935 active site 1041826006936 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1041826006937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1041826006938 substrate binding site [chemical binding]; other site 1041826006939 oxyanion hole (OAH) forming residues; other site 1041826006940 trimer interface [polypeptide binding]; other site 1041826006941 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1041826006942 AAA domain; Region: AAA_28; pfam13521 1041826006943 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 1041826006944 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1041826006945 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1041826006946 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1041826006947 homotetramer interface [polypeptide binding]; other site 1041826006948 ligand binding site [chemical binding]; other site 1041826006949 catalytic site [active] 1041826006950 NAD binding site [chemical binding]; other site 1041826006951 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1041826006952 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1041826006953 PcrB family; Region: PcrB; pfam01884 1041826006954 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 1041826006955 phosphate binding site [ion binding]; other site 1041826006956 Homeodomain-like domain; Region: HTH_23; pfam13384 1041826006957 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1041826006958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1041826006959 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1041826006960 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1041826006961 active site 1041826006962 homodimer interface [polypeptide binding]; other site 1041826006963 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1041826006964 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1041826006965 putative acyl-acceptor binding pocket; other site 1041826006966 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1041826006967 active site 1041826006968 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1041826006969 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193