-- dump date 20140619_092012 -- class Genbank::misc_feature -- table misc_feature_note -- id note 657317000001 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 657317000002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657317000003 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657317000004 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 657317000005 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657317000006 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 657317000007 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657317000008 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657317000009 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 657317000010 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 657317000011 Isochorismatase family; Region: Isochorismatase; pfam00857 657317000012 catalytic triad [active] 657317000013 conserved cis-peptide bond; other site 657317000014 flavodoxin; Provisional; Region: PRK06242 657317000015 flavodoxin; Provisional; Region: PRK06242 657317000016 Chromate transporter; Region: Chromate_transp; pfam02417 657317000017 Chromate transporter; Region: Chromate_transp; pfam02417 657317000018 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 657317000019 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 657317000020 Response regulator receiver domain; Region: Response_reg; pfam00072 657317000021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317000022 active site 657317000023 phosphorylation site [posttranslational modification] 657317000024 intermolecular recognition site; other site 657317000025 dimerization interface [polypeptide binding]; other site 657317000026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317000027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317000028 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317000029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317000030 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317000031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317000032 dimer interface [polypeptide binding]; other site 657317000033 conserved gate region; other site 657317000034 putative PBP binding loops; other site 657317000035 ABC-ATPase subunit interface; other site 657317000036 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 657317000037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000039 sequence-specific DNA binding site [nucleotide binding]; other site 657317000040 salt bridge; other site 657317000041 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317000042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317000043 DNA binding site [nucleotide binding] 657317000044 Int/Topo IB signature motif; other site 657317000045 active site 657317000046 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657317000047 MarR family; Region: MarR_2; cl17246 657317000048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 657317000049 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 657317000050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317000051 Radical SAM superfamily; Region: Radical_SAM; pfam04055 657317000052 FeS/SAM binding site; other site 657317000053 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 657317000054 dimer interface [polypeptide binding]; other site 657317000055 Citrate synthase; Region: Citrate_synt; pfam00285 657317000056 active site 657317000057 citrylCoA binding site [chemical binding]; other site 657317000058 oxalacetate/citrate binding site [chemical binding]; other site 657317000059 coenzyme A binding site [chemical binding]; other site 657317000060 catalytic triad [active] 657317000061 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 657317000062 MarR family; Region: MarR_2; pfam12802 657317000063 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 657317000064 PLD-like domain; Region: PLDc_2; pfam13091 657317000065 putative active site [active] 657317000066 catalytic site [active] 657317000067 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 657317000068 PLD-like domain; Region: PLDc_2; pfam13091 657317000069 putative active site [active] 657317000070 catalytic site [active] 657317000071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317000072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317000073 dimerization interface [polypeptide binding]; other site 657317000074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317000075 dimer interface [polypeptide binding]; other site 657317000076 phosphorylation site [posttranslational modification] 657317000077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317000078 ATP binding site [chemical binding]; other site 657317000079 Mg2+ binding site [ion binding]; other site 657317000080 G-X-G motif; other site 657317000081 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 657317000082 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 657317000083 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 657317000084 active site 657317000085 FtsH Extracellular; Region: FtsH_ext; pfam06480 657317000086 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 657317000087 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 657317000088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317000089 Walker A motif; other site 657317000090 ATP binding site [chemical binding]; other site 657317000091 Walker B motif; other site 657317000092 arginine finger; other site 657317000093 Peptidase family M41; Region: Peptidase_M41; pfam01434 657317000094 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 657317000095 AAA domain; Region: AAA_14; pfam13173 657317000096 Helix-turn-helix domain; Region: HTH_17; pfam12728 657317000097 Helix-turn-helix domain; Region: HTH_17; pfam12728 657317000098 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657317000099 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657317000100 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657317000101 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657317000102 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 657317000103 SdpI/YhfL protein family; Region: SdpI; pfam13630 657317000104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000106 non-specific DNA binding site [nucleotide binding]; other site 657317000107 salt bridge; other site 657317000108 sequence-specific DNA binding site [nucleotide binding]; other site 657317000109 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 657317000110 MPN+ (JAMM) motif; other site 657317000111 Zinc-binding site [ion binding]; other site 657317000112 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 657317000113 Toprim-like; Region: Toprim_2; pfam13155 657317000114 active site 657317000115 metal binding site [ion binding]; metal-binding site 657317000116 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 657317000117 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 657317000118 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 657317000119 AAA-like domain; Region: AAA_10; pfam12846 657317000120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317000121 Walker A motif; other site 657317000122 ATP binding site [chemical binding]; other site 657317000123 Walker B motif; other site 657317000124 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 657317000125 PrgI family protein; Region: PrgI; pfam12666 657317000126 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 657317000127 AAA-like domain; Region: AAA_10; pfam12846 657317000128 Domain of unknown function DUF87; Region: DUF87; pfam01935 657317000129 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657317000130 NlpC/P60 family; Region: NLPC_P60; cl17555 657317000131 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 657317000132 Methyltransferase domain; Region: Methyltransf_26; pfam13659 657317000133 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 657317000134 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 657317000135 DEAD-like helicases superfamily; Region: DEXDc; smart00487 657317000136 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 657317000137 helicase superfamily c-terminal domain; Region: HELICc; smart00490 657317000138 nucleotide binding region [chemical binding]; other site 657317000139 ATP-binding site [chemical binding]; other site 657317000140 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 657317000141 active site 657317000142 catalytic site [active] 657317000143 SpoVG; Region: SpoVG; cl00915 657317000144 SpoVG; Region: SpoVG; pfam04026 657317000145 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317000146 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 657317000147 putative catalytic residues [active] 657317000148 catalytic nucleophile [active] 657317000149 Recombinase; Region: Recombinase; pfam07508 657317000150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 657317000151 H+ Antiporter protein; Region: 2A0121; TIGR00900 657317000152 putative substrate translocation pore; other site 657317000153 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 657317000154 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 657317000155 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 657317000156 metal binding site [ion binding]; metal-binding site 657317000157 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 657317000158 Methyltransferase domain; Region: Methyltransf_11; pfam08241 657317000159 Methyltransferase domain; Region: Methyltransf_23; pfam13489 657317000160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317000161 S-adenosylmethionine binding site [chemical binding]; other site 657317000162 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 657317000163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317000164 FeS/SAM binding site; other site 657317000165 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 657317000166 peptide maturation system protein, TIGR04066 family; Region: nat_prod_clost 657317000167 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 657317000168 active site 657317000169 catalytic triad [active] 657317000170 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317000171 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317000172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317000173 Walker A/P-loop; other site 657317000174 ATP binding site [chemical binding]; other site 657317000175 Q-loop/lid; other site 657317000176 ABC transporter signature motif; other site 657317000177 Walker B; other site 657317000178 D-loop; other site 657317000179 H-loop/switch region; other site 657317000180 Protein of unknown function (DUF419); Region: DUF419; cl15265 657317000181 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317000182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317000183 active site 657317000184 phosphorylation site [posttranslational modification] 657317000185 intermolecular recognition site; other site 657317000186 dimerization interface [polypeptide binding]; other site 657317000187 LytTr DNA-binding domain; Region: LytTR; pfam04397 657317000188 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 657317000189 Staphylococcal AgrD protein; Region: AgrD; cl05477 657317000190 Accessory gene regulator B; Region: AgrB; pfam04647 657317000191 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 657317000192 Transposase; Region: HTH_Tnp_1; cl17663 657317000193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657317000194 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 657317000195 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 657317000196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657317000197 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 657317000198 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657317000199 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 657317000200 Transposase; Region: DEDD_Tnp_IS110; pfam01548 657317000201 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 657317000202 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 657317000203 Accessory gene regulator B; Region: AgrB; pfam04647 657317000204 Staphylococcal AgrD protein; Region: AgrD; cl05477 657317000205 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 657317000206 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 657317000207 putative active site [active] 657317000208 putative NTP binding site [chemical binding]; other site 657317000209 putative nucleic acid binding site [nucleotide binding]; other site 657317000210 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 657317000211 PemK-like protein; Region: PemK; pfam02452 657317000212 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317000213 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317000214 catalytic residues [active] 657317000215 catalytic nucleophile [active] 657317000216 Recombinase; Region: Recombinase; pfam07508 657317000217 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317000218 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317000219 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317000220 catalytic residues [active] 657317000221 catalytic nucleophile [active] 657317000222 Recombinase; Region: Recombinase; pfam07508 657317000223 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317000224 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317000225 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317000226 catalytic residues [active] 657317000227 catalytic nucleophile [active] 657317000228 Recombinase; Region: Recombinase; pfam07508 657317000229 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317000230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317000231 Walker B; other site 657317000232 D-loop; other site 657317000233 H-loop/switch region; other site 657317000234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317000235 Walker A/P-loop; other site 657317000236 ATP binding site [chemical binding]; other site 657317000237 Q-loop/lid; other site 657317000238 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 657317000239 MobA/MobL family; Region: MobA_MobL; pfam03389 657317000240 Helix-turn-helix domain; Region: HTH_17; cl17695 657317000241 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000243 non-specific DNA binding site [nucleotide binding]; other site 657317000244 salt bridge; other site 657317000245 sequence-specific DNA binding site [nucleotide binding]; other site 657317000246 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317000247 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317000248 Int/Topo IB signature motif; other site 657317000249 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657317000250 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657317000251 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 657317000252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 657317000253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657317000254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 657317000255 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657317000256 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 657317000257 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657317000258 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 657317000259 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 657317000260 putative substrate binding site [chemical binding]; other site 657317000261 putative ATP binding site [chemical binding]; other site 657317000262 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 657317000263 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657317000264 active site 657317000265 phosphorylation site [posttranslational modification] 657317000266 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 657317000267 active site 657317000268 P-loop; other site 657317000269 phosphorylation site [posttranslational modification] 657317000270 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 657317000271 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 657317000272 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 657317000273 nucleotide binding site [chemical binding]; other site 657317000274 NEF interaction site [polypeptide binding]; other site 657317000275 SBD interface [polypeptide binding]; other site 657317000276 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317000277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317000278 active site 657317000279 phosphorylation site [posttranslational modification] 657317000280 intermolecular recognition site; other site 657317000281 dimerization interface [polypeptide binding]; other site 657317000282 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317000283 DNA binding site [nucleotide binding] 657317000284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317000285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317000286 dimer interface [polypeptide binding]; other site 657317000287 phosphorylation site [posttranslational modification] 657317000288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317000289 ATP binding site [chemical binding]; other site 657317000290 Mg2+ binding site [ion binding]; other site 657317000291 G-X-G motif; other site 657317000292 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 657317000293 Domain of unknown function DUF20; Region: UPF0118; pfam01594 657317000294 glycogen branching enzyme; Provisional; Region: PRK12313 657317000295 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 657317000296 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 657317000297 active site 657317000298 catalytic site [active] 657317000299 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 657317000300 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 657317000301 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657317000302 active site 657317000303 metal binding site [ion binding]; metal-binding site 657317000304 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 657317000305 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 657317000306 active site 657317000307 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 657317000308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657317000309 active site 657317000310 ATP binding site [chemical binding]; other site 657317000311 substrate binding site [chemical binding]; other site 657317000312 activation loop (A-loop); other site 657317000313 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 657317000314 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 657317000315 flagellin; Provisional; Region: PRK12806 657317000316 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657317000317 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657317000318 Flagellar protein FliS; Region: FliS; cl00654 657317000319 AAA domain; Region: AAA_31; pfam13614 657317000320 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 657317000321 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 657317000322 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 657317000323 phosphopeptide binding site; other site 657317000324 SCP-2 sterol transfer family; Region: SCP2; pfam02036 657317000325 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 657317000326 HIT family signature motif; other site 657317000327 catalytic residue [active] 657317000328 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 657317000329 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 657317000330 active site 657317000331 homodimer interface [polypeptide binding]; other site 657317000332 Bacterial SH3 domain; Region: SH3_3; pfam08239 657317000333 Bacterial SH3 domain; Region: SH3_3; cl17532 657317000334 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 657317000335 ornithine carbamoyltransferase; Validated; Region: PRK02102 657317000336 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657317000337 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657317000338 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 657317000339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317000340 DNA-binding site [nucleotide binding]; DNA binding site 657317000341 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 657317000342 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 657317000343 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657317000344 nucleotide binding site [chemical binding]; other site 657317000345 Type III pantothenate kinase; Region: Pan_kinase; cl17198 657317000346 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 657317000347 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 657317000348 FMN binding site [chemical binding]; other site 657317000349 active site 657317000350 catalytic residues [active] 657317000351 substrate binding site [chemical binding]; other site 657317000352 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 657317000353 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 657317000354 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 657317000355 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 657317000356 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 657317000357 dimer interface [polypeptide binding]; other site 657317000358 putative anticodon binding site; other site 657317000359 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 657317000360 motif 1; other site 657317000361 active site 657317000362 motif 2; other site 657317000363 motif 3; other site 657317000364 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 657317000365 Cna protein B-type domain; Region: Cna_B; pfam05738 657317000366 Cna protein B-type domain; Region: Cna_B; pfam05738 657317000367 Cna protein B-type domain; Region: Cna_B; pfam05738 657317000368 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 657317000369 DNA polymerase IV; Reviewed; Region: PRK03103 657317000370 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 657317000371 active site 657317000372 DNA binding site [nucleotide binding] 657317000373 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 657317000374 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 657317000375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000377 non-specific DNA binding site [nucleotide binding]; other site 657317000378 salt bridge; other site 657317000379 sequence-specific DNA binding site [nucleotide binding]; other site 657317000380 Resolvase, N terminal domain; Region: Resolvase; smart00857 657317000381 catalytic residues [active] 657317000382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000384 non-specific DNA binding site [nucleotide binding]; other site 657317000385 salt bridge; other site 657317000386 sequence-specific DNA binding site [nucleotide binding]; other site 657317000387 Resolvase, N terminal domain; Region: Resolvase; smart00857 657317000388 PemK-like protein; Region: PemK; pfam02452 657317000389 integron integrase; Region: integrase_gron; TIGR02249 657317000390 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317000391 Int/Topo IB signature motif; other site 657317000392 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 657317000393 dimer interface [polypeptide binding]; other site 657317000394 putative tRNA-binding site [nucleotide binding]; other site 657317000395 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657317000396 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 657317000397 DNA binding residues [nucleotide binding] 657317000398 dimer interface [polypeptide binding]; other site 657317000399 hypothetical protein; Validated; Region: PRK07668 657317000400 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 657317000401 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 657317000402 Walker A/P-loop; other site 657317000403 ATP binding site [chemical binding]; other site 657317000404 Q-loop/lid; other site 657317000405 ABC transporter signature motif; other site 657317000406 Walker B; other site 657317000407 D-loop; other site 657317000408 H-loop/switch region; other site 657317000409 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 657317000410 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657317000411 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 657317000412 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657317000413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317000414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317000415 active site 657317000416 phosphorylation site [posttranslational modification] 657317000417 intermolecular recognition site; other site 657317000418 dimerization interface [polypeptide binding]; other site 657317000419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317000420 DNA binding site [nucleotide binding] 657317000421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317000422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317000423 dimer interface [polypeptide binding]; other site 657317000424 phosphorylation site [posttranslational modification] 657317000425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317000426 ATP binding site [chemical binding]; other site 657317000427 Mg2+ binding site [ion binding]; other site 657317000428 G-X-G motif; other site 657317000429 septum formation inhibitor; Reviewed; Region: minC; PRK00513 657317000430 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 657317000431 septum site-determining protein MinD; Region: minD_bact; TIGR01968 657317000432 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 657317000433 Switch I; other site 657317000434 Switch II; other site 657317000435 Septum formation topological specificity factor MinE; Region: MinE; cl00538 657317000436 hypothetical protein; Provisional; Region: PRK09609 657317000437 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657317000438 acetylornithine aminotransferase; Provisional; Region: PRK02627 657317000439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 657317000440 inhibitor-cofactor binding pocket; inhibition site 657317000441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317000442 catalytic residue [active] 657317000443 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657317000444 ethanolamine permease; Region: 2A0305; TIGR00908 657317000445 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 657317000446 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 657317000447 active site 657317000448 metal binding site [ion binding]; metal-binding site 657317000449 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 657317000450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000451 non-specific DNA binding site [nucleotide binding]; other site 657317000452 salt bridge; other site 657317000453 sequence-specific DNA binding site [nucleotide binding]; other site 657317000454 Cupin domain; Region: Cupin_2; pfam07883 657317000455 Helix-turn-helix domain; Region: HTH_17; cl17695 657317000456 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317000457 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317000458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317000459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317000460 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 657317000461 Walker A/P-loop; other site 657317000462 ATP binding site [chemical binding]; other site 657317000463 Q-loop/lid; other site 657317000464 ABC transporter signature motif; other site 657317000465 Walker B; other site 657317000466 D-loop; other site 657317000467 H-loop/switch region; other site 657317000468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 657317000469 active site 657317000470 motif I; other site 657317000471 motif II; other site 657317000472 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 657317000473 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 657317000474 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657317000475 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 657317000476 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657317000477 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657317000478 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 657317000479 FliW protein; Region: FliW; cl00740 657317000480 Global regulator protein family; Region: CsrA; pfam02599 657317000481 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 657317000482 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 657317000483 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 657317000484 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 657317000485 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 657317000486 Low molecular weight phosphatase family; Region: LMWPc; cl00105 657317000487 active site 657317000488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657317000489 active site 657317000490 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 657317000491 catalytic motif [active] 657317000492 Zn binding site [ion binding]; other site 657317000493 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 657317000494 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 657317000495 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 657317000496 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657317000497 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 657317000498 beta subunit interaction interface [polypeptide binding]; other site 657317000499 Walker A motif; other site 657317000500 ATP binding site [chemical binding]; other site 657317000501 Walker B motif; other site 657317000502 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657317000503 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 657317000504 core domain interface [polypeptide binding]; other site 657317000505 delta subunit interface [polypeptide binding]; other site 657317000506 epsilon subunit interface [polypeptide binding]; other site 657317000507 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 657317000508 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657317000509 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 657317000510 alpha subunit interaction interface [polypeptide binding]; other site 657317000511 Walker A motif; other site 657317000512 ATP binding site [chemical binding]; other site 657317000513 Walker B motif; other site 657317000514 inhibitor binding site; inhibition site 657317000515 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657317000516 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 657317000517 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 657317000518 gamma subunit interface [polypeptide binding]; other site 657317000519 epsilon subunit interface [polypeptide binding]; other site 657317000520 LBP interface [polypeptide binding]; other site 657317000521 Cupin domain; Region: Cupin_2; cl17218 657317000522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317000523 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317000524 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 657317000525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317000526 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 657317000527 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657317000528 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317000529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317000530 dimer interface [polypeptide binding]; other site 657317000531 conserved gate region; other site 657317000532 putative PBP binding loops; other site 657317000533 ABC-ATPase subunit interface; other site 657317000534 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 657317000535 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 657317000536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657317000537 active site 657317000538 Phosphotransferase enzyme family; Region: APH; pfam01636 657317000539 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 657317000540 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 657317000541 putative FMN binding site [chemical binding]; other site 657317000542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317000543 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317000544 Int/Topo IB signature motif; other site 657317000545 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000547 non-specific DNA binding site [nucleotide binding]; other site 657317000548 salt bridge; other site 657317000549 sequence-specific DNA binding site [nucleotide binding]; other site 657317000550 Helix-turn-helix domain; Region: HTH_17; cl17695 657317000551 MobA/MobL family; Region: MobA_MobL; pfam03389 657317000552 Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995 657317000553 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 657317000554 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 657317000555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657317000556 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657317000557 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 657317000558 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657317000559 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657317000560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317000561 Coenzyme A binding pocket [chemical binding]; other site 657317000562 Predicted amidohydrolase [General function prediction only]; Region: COG0388 657317000563 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 657317000564 active site 657317000565 catalytic triad [active] 657317000566 dimer interface [polypeptide binding]; other site 657317000567 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000569 non-specific DNA binding site [nucleotide binding]; other site 657317000570 salt bridge; other site 657317000571 sequence-specific DNA binding site [nucleotide binding]; other site 657317000572 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317000573 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 657317000574 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 657317000575 putative active site [active] 657317000576 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 657317000577 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657317000578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317000579 motif II; other site 657317000580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317000581 DNA-binding site [nucleotide binding]; DNA binding site 657317000582 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657317000583 UTRA domain; Region: UTRA; pfam07702 657317000584 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 657317000585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317000586 DNA-binding site [nucleotide binding]; DNA binding site 657317000587 UTRA domain; Region: UTRA; pfam07702 657317000588 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 657317000589 active pocket/dimerization site; other site 657317000590 active site 657317000591 phosphorylation site [posttranslational modification] 657317000592 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 657317000593 active site 657317000594 phosphorylation site [posttranslational modification] 657317000595 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 657317000596 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 657317000597 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 657317000598 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 657317000599 dimer interface [polypeptide binding]; other site 657317000600 active site 657317000601 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 657317000602 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 657317000603 active site 657317000604 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 657317000605 dimer interface [polypeptide binding]; other site 657317000606 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 657317000607 Ligand Binding Site [chemical binding]; other site 657317000608 Molecular Tunnel; other site 657317000609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317000610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317000611 Walker A/P-loop; other site 657317000612 ATP binding site [chemical binding]; other site 657317000613 Q-loop/lid; other site 657317000614 ABC transporter signature motif; other site 657317000615 Walker B; other site 657317000616 D-loop; other site 657317000617 H-loop/switch region; other site 657317000618 FtsX-like permease family; Region: FtsX; pfam02687 657317000619 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657317000620 FtsX-like permease family; Region: FtsX; pfam02687 657317000621 HAMP domain; Region: HAMP; pfam00672 657317000622 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657317000623 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317000624 dimer interface [polypeptide binding]; other site 657317000625 putative CheW interface [polypeptide binding]; other site 657317000626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317000627 Coenzyme A binding pocket [chemical binding]; other site 657317000628 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 657317000629 PLD-like domain; Region: PLDc_2; pfam13091 657317000630 putative homodimer interface [polypeptide binding]; other site 657317000631 putative active site [active] 657317000632 catalytic site [active] 657317000633 DEAD-like helicases superfamily; Region: DEXDc; smart00487 657317000634 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317000635 ATP binding site [chemical binding]; other site 657317000636 putative Mg++ binding site [ion binding]; other site 657317000637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317000638 nucleotide binding region [chemical binding]; other site 657317000639 ATP-binding site [chemical binding]; other site 657317000640 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 657317000641 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 657317000642 active site 657317000643 8-oxo-dGMP binding site [chemical binding]; other site 657317000644 nudix motif; other site 657317000645 metal binding site [ion binding]; metal-binding site 657317000646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317000647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000648 non-specific DNA binding site [nucleotide binding]; other site 657317000649 salt bridge; other site 657317000650 sequence-specific DNA binding site [nucleotide binding]; other site 657317000651 Domain of unknown function (DUF955); Region: DUF955; pfam06114 657317000652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657317000653 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 657317000654 AAA domain; Region: AAA_12; pfam13087 657317000655 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 657317000656 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 657317000657 TIGR02300 family protein; Region: FYDLN_acid 657317000658 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 657317000659 putative active site [active] 657317000660 nucleotide binding site [chemical binding]; other site 657317000661 nudix motif; other site 657317000662 putative metal binding site [ion binding]; other site 657317000663 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317000664 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317000665 DNA binding site [nucleotide binding] 657317000666 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317000667 ligand binding site [chemical binding]; other site 657317000668 dimerization interface [polypeptide binding]; other site 657317000669 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657317000670 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657317000671 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 657317000672 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657317000673 ligand binding site [chemical binding]; other site 657317000674 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 657317000675 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 657317000676 Walker A/P-loop; other site 657317000677 ATP binding site [chemical binding]; other site 657317000678 Q-loop/lid; other site 657317000679 ABC transporter signature motif; other site 657317000680 Walker B; other site 657317000681 D-loop; other site 657317000682 H-loop/switch region; other site 657317000683 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657317000684 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657317000685 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657317000686 TM-ABC transporter signature motif; other site 657317000687 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 657317000688 active site 657317000689 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 657317000690 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 657317000691 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657317000692 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 657317000693 putative substrate binding site [chemical binding]; other site 657317000694 putative ATP binding site [chemical binding]; other site 657317000695 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 657317000696 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 657317000697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317000698 Walker A/P-loop; other site 657317000699 ATP binding site [chemical binding]; other site 657317000700 Q-loop/lid; other site 657317000701 ABC transporter signature motif; other site 657317000702 Walker B; other site 657317000703 D-loop; other site 657317000704 H-loop/switch region; other site 657317000705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657317000706 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 657317000707 TM-ABC transporter signature motif; other site 657317000708 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 657317000709 zinc binding site [ion binding]; other site 657317000710 putative ligand binding site [chemical binding]; other site 657317000711 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 657317000712 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 657317000713 active site 657317000714 HIGH motif; other site 657317000715 dimer interface [polypeptide binding]; other site 657317000716 KMSKS motif; other site 657317000717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317000718 RNA binding surface [nucleotide binding]; other site 657317000719 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 657317000720 Sodium Bile acid symporter family; Region: SBF; pfam01758 657317000721 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 657317000722 Carbon starvation protein CstA; Region: CstA; pfam02554 657317000723 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 657317000724 EDD domain protein, DegV family; Region: DegV; TIGR00762 657317000725 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657317000726 endonuclease IV; Provisional; Region: PRK01060 657317000727 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 657317000728 AP (apurinic/apyrimidinic) site pocket; other site 657317000729 DNA interaction; other site 657317000730 Metal-binding active site; metal-binding site 657317000731 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 657317000732 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 657317000733 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 657317000734 putative active site [active] 657317000735 catalytic site [active] 657317000736 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 657317000737 putative active site [active] 657317000738 catalytic site [active] 657317000739 Acylphosphatase; Region: Acylphosphatase; pfam00708 657317000740 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 657317000741 PIN domain; Region: PIN_3; pfam13470 657317000742 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 657317000743 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 657317000744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317000745 active site 657317000746 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317000747 phosphorylation site [posttranslational modification] 657317000748 intermolecular recognition site; other site 657317000749 dimerization interface [polypeptide binding]; other site 657317000750 LytTr DNA-binding domain; Region: LytTR; smart00850 657317000751 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 657317000752 Staphylococcal AgrD protein; Region: AgrD; cl05477 657317000753 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 657317000754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317000755 Walker A/P-loop; other site 657317000756 ATP binding site [chemical binding]; other site 657317000757 Q-loop/lid; other site 657317000758 ABC transporter signature motif; other site 657317000759 Walker B; other site 657317000760 D-loop; other site 657317000761 H-loop/switch region; other site 657317000762 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317000763 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 657317000764 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 657317000765 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317000766 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317000767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317000768 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 657317000769 zinc binding site [ion binding]; other site 657317000770 putative ligand binding site [chemical binding]; other site 657317000771 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 657317000772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317000773 Walker A/P-loop; other site 657317000774 ATP binding site [chemical binding]; other site 657317000775 Q-loop/lid; other site 657317000776 ABC transporter signature motif; other site 657317000777 Walker B; other site 657317000778 D-loop; other site 657317000779 H-loop/switch region; other site 657317000780 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 657317000781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317000782 non-specific DNA binding site [nucleotide binding]; other site 657317000783 salt bridge; other site 657317000784 sequence-specific DNA binding site [nucleotide binding]; other site 657317000785 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 657317000786 thiamine phosphate binding site [chemical binding]; other site 657317000787 active site 657317000788 pyrophosphate binding site [ion binding]; other site 657317000789 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 657317000790 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 657317000791 FeS/SAM binding site; other site 657317000792 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 657317000793 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 657317000794 ThiS interaction site; other site 657317000795 putative active site [active] 657317000796 tetramer interface [polypeptide binding]; other site 657317000797 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 657317000798 thiS-thiF/thiG interaction site; other site 657317000799 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 657317000800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 657317000801 active site 657317000802 dimer interface [polypeptide binding]; other site 657317000803 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 657317000804 dimer interface [polypeptide binding]; other site 657317000805 active site 657317000806 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 657317000807 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 657317000808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317000809 FeS/SAM binding site; other site 657317000810 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 657317000811 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 657317000812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317000813 FeS/SAM binding site; other site 657317000814 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 657317000815 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 657317000816 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 657317000817 G1 box; other site 657317000818 GTP/Mg2+ binding site [chemical binding]; other site 657317000819 Switch I region; other site 657317000820 G2 box; other site 657317000821 Switch II region; other site 657317000822 G3 box; other site 657317000823 G4 box; other site 657317000824 G5 box; other site 657317000825 Domain of unknown function, E. rectale Gene description (DUF3877); Region: DUF3877; pfam12993 657317000826 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657317000827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657317000828 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 657317000829 active site 657317000830 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 657317000831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317000832 S-adenosylmethionine binding site [chemical binding]; other site 657317000833 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 657317000834 Peptidase family M23; Region: Peptidase_M23; pfam01551 657317000835 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 657317000836 GIY-YIG motif/motif A; other site 657317000837 putative active site [active] 657317000838 putative metal binding site [ion binding]; other site 657317000839 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 657317000840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317000841 dimer interface [polypeptide binding]; other site 657317000842 conserved gate region; other site 657317000843 putative PBP binding loops; other site 657317000844 ABC-ATPase subunit interface; other site 657317000845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317000846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317000847 dimer interface [polypeptide binding]; other site 657317000848 conserved gate region; other site 657317000849 putative PBP binding loops; other site 657317000850 ABC-ATPase subunit interface; other site 657317000851 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317000852 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317000853 DNA binding site [nucleotide binding] 657317000854 domain linker motif; other site 657317000855 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317000856 ligand binding site [chemical binding]; other site 657317000857 dimerization interface [polypeptide binding]; other site 657317000858 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 657317000859 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317000860 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657317000861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317000862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317000863 DNA binding site [nucleotide binding] 657317000864 domain linker motif; other site 657317000865 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657317000866 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657317000867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317000868 dimer interface [polypeptide binding]; other site 657317000869 conserved gate region; other site 657317000870 putative PBP binding loops; other site 657317000871 ABC-ATPase subunit interface; other site 657317000872 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317000873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317000874 dimer interface [polypeptide binding]; other site 657317000875 conserved gate region; other site 657317000876 putative PBP binding loops; other site 657317000877 ABC-ATPase subunit interface; other site 657317000878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317000879 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 657317000880 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 657317000881 substrate binding [chemical binding]; other site 657317000882 active site 657317000883 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 657317000884 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657317000885 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 657317000886 putative substrate binding site [chemical binding]; other site 657317000887 putative ATP binding site [chemical binding]; other site 657317000888 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317000889 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317000890 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 657317000891 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 657317000892 Sulfate transporter family; Region: Sulfate_transp; pfam00916 657317000893 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 657317000894 DEAD-like helicases superfamily; Region: DEXDc; smart00487 657317000895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317000896 ATP binding site [chemical binding]; other site 657317000897 putative Mg++ binding site [ion binding]; other site 657317000898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317000899 nucleotide binding region [chemical binding]; other site 657317000900 ATP-binding site [chemical binding]; other site 657317000901 HRDC domain; Region: HRDC; pfam00570 657317000902 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 657317000903 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 657317000904 active site 657317000905 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 657317000906 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 657317000907 putative oligomer interface [polypeptide binding]; other site 657317000908 putative active site [active] 657317000909 metal binding site [ion binding]; metal-binding site 657317000910 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 657317000911 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657317000912 putative metal binding site [ion binding]; other site 657317000913 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 657317000914 trimer interface [polypeptide binding]; other site 657317000915 putative Zn binding site [ion binding]; other site 657317000916 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 657317000917 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 657317000918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317000919 active site 657317000920 DNA binding site [nucleotide binding] 657317000921 Int/Topo IB signature motif; other site 657317000922 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 657317000923 Putative transposase; Region: Y2_Tnp; pfam04986 657317000924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317000926 active site 657317000927 phosphorylation site [posttranslational modification] 657317000928 intermolecular recognition site; other site 657317000929 dimerization interface [polypeptide binding]; other site 657317000930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317000931 DNA binding site [nucleotide binding] 657317000932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317000933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317000934 Walker A/P-loop; other site 657317000935 ATP binding site [chemical binding]; other site 657317000936 Q-loop/lid; other site 657317000937 ABC transporter signature motif; other site 657317000938 Walker B; other site 657317000939 D-loop; other site 657317000940 H-loop/switch region; other site 657317000941 FtsX-like permease family; Region: FtsX; pfam02687 657317000942 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657317000943 FtsX-like permease family; Region: FtsX; pfam02687 657317000944 Rubredoxin [Energy production and conversion]; Region: COG1773 657317000945 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 657317000946 iron binding site [ion binding]; other site 657317000947 Rubrerythrin [Energy production and conversion]; Region: COG1592 657317000948 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 657317000949 diiron binding motif [ion binding]; other site 657317000950 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 657317000951 metal binding site 2 [ion binding]; metal-binding site 657317000952 putative DNA binding helix; other site 657317000953 metal binding site 1 [ion binding]; metal-binding site 657317000954 dimer interface [polypeptide binding]; other site 657317000955 structural Zn2+ binding site [ion binding]; other site 657317000956 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 657317000957 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 657317000958 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 657317000959 intersubunit interface [polypeptide binding]; other site 657317000960 active site 657317000961 catalytic residue [active] 657317000962 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 657317000963 active site 657317000964 catalytic motif [active] 657317000965 Zn binding site [ion binding]; other site 657317000966 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 657317000967 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657317000968 active site 657317000969 phosphopentomutase; Provisional; Region: PRK05362 657317000970 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 657317000971 purine nucleoside phosphorylase; Provisional; Region: PRK08202 657317000972 AAA domain; Region: AAA_22; pfam13401 657317000973 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 657317000974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657317000975 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 657317000976 nucleoside/Zn binding site; other site 657317000977 dimer interface [polypeptide binding]; other site 657317000978 catalytic motif [active] 657317000979 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 657317000980 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 657317000981 putative NADH binding site [chemical binding]; other site 657317000982 putative active site [active] 657317000983 nudix motif; other site 657317000984 putative metal binding site [ion binding]; other site 657317000985 Transcriptional regulator; Region: Rrf2; cl17282 657317000986 Rrf2 family protein; Region: rrf2_super; TIGR00738 657317000987 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 657317000988 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 657317000989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317000990 catalytic residue [active] 657317000991 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 657317000992 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 657317000993 trimerization site [polypeptide binding]; other site 657317000994 active site 657317000995 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 657317000996 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 657317000997 Archaeal ATPase; Region: Arch_ATPase; pfam01637 657317000998 AAA ATPase domain; Region: AAA_16; pfam13191 657317000999 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 657317001000 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 657317001001 dimer interface [polypeptide binding]; other site 657317001002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317001003 catalytic residue [active] 657317001004 HipA N-terminal domain; Region: Couple_hipA; pfam13657 657317001005 HipA-like N-terminal domain; Region: HipA_N; pfam07805 657317001006 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 657317001007 HipA-like C-terminal domain; Region: HipA_C; pfam07804 657317001008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317001009 non-specific DNA binding site [nucleotide binding]; other site 657317001010 salt bridge; other site 657317001011 sequence-specific DNA binding site [nucleotide binding]; other site 657317001012 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 657317001013 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317001014 FeS/SAM binding site; other site 657317001015 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 657317001016 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 657317001017 dimer interface [polypeptide binding]; other site 657317001018 pyridoxal binding site [chemical binding]; other site 657317001019 ATP binding site [chemical binding]; other site 657317001020 Protein of unknown function, DUF624; Region: DUF624; pfam04854 657317001021 6-phosphofructokinase; Provisional; Region: PRK03202 657317001022 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657317001023 active site 657317001024 ADP/pyrophosphate binding site [chemical binding]; other site 657317001025 dimerization interface [polypeptide binding]; other site 657317001026 allosteric effector site; other site 657317001027 fructose-1,6-bisphosphate binding site; other site 657317001028 hypothetical protein; Validated; Region: PRK00153 657317001029 recombination protein RecR; Reviewed; Region: recR; PRK00076 657317001030 RecR protein; Region: RecR; pfam02132 657317001031 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 657317001032 putative active site [active] 657317001033 putative metal-binding site [ion binding]; other site 657317001034 tetramer interface [polypeptide binding]; other site 657317001035 transketolase; Reviewed; Region: PRK05899 657317001036 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 657317001037 TPP-binding site [chemical binding]; other site 657317001038 dimer interface [polypeptide binding]; other site 657317001039 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 657317001040 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 657317001041 PYR/PP interface [polypeptide binding]; other site 657317001042 dimer interface [polypeptide binding]; other site 657317001043 TPP binding site [chemical binding]; other site 657317001044 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657317001045 Colicin V production protein; Region: Colicin_V; pfam02674 657317001046 Predicted integral membrane protein [Function unknown]; Region: COG5658 657317001047 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 657317001048 SdpI/YhfL protein family; Region: SdpI; pfam13630 657317001049 Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995 657317001050 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 657317001051 ATP binding site [chemical binding]; other site 657317001052 Mg2+ binding site [ion binding]; other site 657317001053 G-X-G motif; other site 657317001054 Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995 657317001055 uracil-xanthine permease; Region: ncs2; TIGR00801 657317001056 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 657317001057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317001058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317001059 metal binding site [ion binding]; metal-binding site 657317001060 active site 657317001061 I-site; other site 657317001062 Sulfatase; Region: Sulfatase; pfam00884 657317001063 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 657317001064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657317001065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317001066 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 657317001067 ATP binding site [chemical binding]; other site 657317001068 putative Mg++ binding site [ion binding]; other site 657317001069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317001070 nucleotide binding region [chemical binding]; other site 657317001071 ATP-binding site [chemical binding]; other site 657317001072 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 657317001073 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 657317001074 active site 657317001075 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 657317001076 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 657317001077 Poxvirus M2 protein; Region: Pox_M2; pfam04887 657317001078 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 657317001079 active site 657317001080 DNA polymerase I; Provisional; Region: PRK05755 657317001081 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 657317001082 active site 657317001083 metal binding site 1 [ion binding]; metal-binding site 657317001084 putative 5' ssDNA interaction site; other site 657317001085 metal binding site 3; metal-binding site 657317001086 metal binding site 2 [ion binding]; metal-binding site 657317001087 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 657317001088 putative DNA binding site [nucleotide binding]; other site 657317001089 putative metal binding site [ion binding]; other site 657317001090 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 657317001091 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 657317001092 active site 657317001093 DNA binding site [nucleotide binding] 657317001094 catalytic site [active] 657317001095 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 657317001096 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 657317001097 CoA-binding site [chemical binding]; other site 657317001098 ATP-binding [chemical binding]; other site 657317001099 cell division protein FtsA; Region: ftsA; TIGR01174 657317001100 Cell division protein FtsA; Region: FtsA; smart00842 657317001101 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657317001102 nucleotide binding site [chemical binding]; other site 657317001103 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 657317001104 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 657317001105 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 657317001106 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 657317001107 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 657317001108 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 657317001109 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 657317001110 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 657317001111 Part of AAA domain; Region: AAA_19; pfam13245 657317001112 Family description; Region: UvrD_C_2; pfam13538 657317001113 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 657317001114 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 657317001115 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 657317001116 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 657317001117 active site 657317001118 heat shock protein 90; Provisional; Region: PRK05218 657317001119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317001120 ATP binding site [chemical binding]; other site 657317001121 Mg2+ binding site [ion binding]; other site 657317001122 G-X-G motif; other site 657317001123 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 657317001124 active site 1 [active] 657317001125 active site 2 [active] 657317001126 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 657317001127 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 657317001128 serine O-acetyltransferase; Region: cysE; TIGR01172 657317001129 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 657317001130 trimer interface [polypeptide binding]; other site 657317001131 active site 657317001132 substrate binding site [chemical binding]; other site 657317001133 CoA binding site [chemical binding]; other site 657317001134 FeoA domain; Region: FeoA; pfam04023 657317001135 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 657317001136 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 657317001137 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 657317001138 G1 box; other site 657317001139 GTP/Mg2+ binding site [chemical binding]; other site 657317001140 Switch I region; other site 657317001141 G2 box; other site 657317001142 G3 box; other site 657317001143 Switch II region; other site 657317001144 G4 box; other site 657317001145 G5 box; other site 657317001146 Nucleoside recognition; Region: Gate; pfam07670 657317001147 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 657317001148 Nucleoside recognition; Region: Gate; pfam07670 657317001149 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 657317001150 putative DNA binding helix; other site 657317001151 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 657317001152 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 657317001153 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 657317001154 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 657317001155 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317001156 Int/Topo IB signature motif; other site 657317001157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317001158 ATP binding site [chemical binding]; other site 657317001159 putative Mg++ binding site [ion binding]; other site 657317001160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317001161 nucleotide binding region [chemical binding]; other site 657317001162 ATP-binding site [chemical binding]; other site 657317001163 Helicase associated domain; Region: HA; pfam03457 657317001164 Helicase associated domain; Region: HA; pfam03457 657317001165 Helicase associated domain; Region: HA; pfam03457 657317001166 Helicase associated domain; Region: HA; pfam03457 657317001167 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657317001168 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657317001169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 657317001170 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 657317001171 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 657317001172 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657317001173 active site 657317001174 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657317001175 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 657317001176 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657317001177 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 657317001178 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 657317001179 ligand binding site; other site 657317001180 tetramer interface; other site 657317001181 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 657317001182 active site 657317001183 catalytic residues [active] 657317001184 metal binding site [ion binding]; metal-binding site 657317001185 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 657317001186 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 657317001187 PYR/PP interface [polypeptide binding]; other site 657317001188 dimer interface [polypeptide binding]; other site 657317001189 TPP binding site [chemical binding]; other site 657317001190 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 657317001191 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 657317001192 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 657317001193 TPP-binding site [chemical binding]; other site 657317001194 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657317001195 Domain of unknown function (DUF386); Region: DUF386; cl01047 657317001196 DNA repair protein RadA; Provisional; Region: PRK11823 657317001197 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 657317001198 Walker A motif/ATP binding site; other site 657317001199 ATP binding site [chemical binding]; other site 657317001200 Walker B motif; other site 657317001201 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 657317001202 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 657317001203 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 657317001204 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 657317001205 Predicted secreted protein [Function unknown]; Region: COG4086 657317001206 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 657317001207 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 657317001208 putative dimer interface [polypeptide binding]; other site 657317001209 catalytic triad [active] 657317001210 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 657317001211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317001212 FeS/SAM binding site; other site 657317001213 6-phosphofructokinase; Provisional; Region: PRK14072 657317001214 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657317001215 active site 657317001216 ADP/pyrophosphate binding site [chemical binding]; other site 657317001217 dimerization interface [polypeptide binding]; other site 657317001218 allosteric effector site; other site 657317001219 fructose-1,6-bisphosphate binding site; other site 657317001220 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 657317001221 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 657317001222 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317001223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317001224 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657317001225 Walker A/P-loop; other site 657317001226 ATP binding site [chemical binding]; other site 657317001227 Q-loop/lid; other site 657317001228 ABC transporter signature motif; other site 657317001229 Walker B; other site 657317001230 D-loop; other site 657317001231 H-loop/switch region; other site 657317001232 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317001233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317001234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317001235 Walker A/P-loop; other site 657317001236 ATP binding site [chemical binding]; other site 657317001237 Q-loop/lid; other site 657317001238 ABC transporter signature motif; other site 657317001239 Walker B; other site 657317001240 D-loop; other site 657317001241 H-loop/switch region; other site 657317001242 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 657317001243 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 657317001244 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 657317001245 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 657317001246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317001247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317001248 homodimer interface [polypeptide binding]; other site 657317001249 catalytic residue [active] 657317001250 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 657317001251 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 657317001252 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 657317001253 NAD binding site [chemical binding]; other site 657317001254 dimer interface [polypeptide binding]; other site 657317001255 substrate binding site [chemical binding]; other site 657317001256 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657317001257 2-isopropylmalate synthase; Validated; Region: PRK03739 657317001258 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 657317001259 active site 657317001260 catalytic residues [active] 657317001261 metal binding site [ion binding]; metal-binding site 657317001262 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 657317001263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317001264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317001265 EDD domain protein, DegV family; Region: DegV; TIGR00762 657317001266 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657317001267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 657317001268 Sterol carrier protein domain; Region: SCP2_2; pfam13530 657317001269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657317001270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317001271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317001272 metal binding site [ion binding]; metal-binding site 657317001273 active site 657317001274 I-site; other site 657317001275 Thiamine pyrophosphokinase; Region: TPK; cd07995 657317001276 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 657317001277 active site 657317001278 dimerization interface [polypeptide binding]; other site 657317001279 thiamine binding site [chemical binding]; other site 657317001280 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 657317001281 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 657317001282 substrate binding site [chemical binding]; other site 657317001283 hexamer interface [polypeptide binding]; other site 657317001284 metal binding site [ion binding]; metal-binding site 657317001285 GTPase RsgA; Reviewed; Region: PRK00098 657317001286 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 657317001287 RNA binding site [nucleotide binding]; other site 657317001288 homodimer interface [polypeptide binding]; other site 657317001289 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 657317001290 GTPase/Zn-binding domain interface [polypeptide binding]; other site 657317001291 GTP/Mg2+ binding site [chemical binding]; other site 657317001292 G4 box; other site 657317001293 G5 box; other site 657317001294 G1 box; other site 657317001295 Switch I region; other site 657317001296 G2 box; other site 657317001297 G3 box; other site 657317001298 Switch II region; other site 657317001299 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657317001300 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657317001301 active site 657317001302 ATP binding site [chemical binding]; other site 657317001303 substrate binding site [chemical binding]; other site 657317001304 activation loop (A-loop); other site 657317001305 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657317001306 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657317001307 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 657317001308 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 657317001309 Protein phosphatase 2C; Region: PP2C; pfam00481 657317001310 active site 657317001311 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 657317001312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317001313 FeS/SAM binding site; other site 657317001314 16S rRNA methyltransferase B; Provisional; Region: PRK14902 657317001315 NusB family; Region: NusB; pfam01029 657317001316 putative RNA binding site [nucleotide binding]; other site 657317001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317001318 S-adenosylmethionine binding site [chemical binding]; other site 657317001319 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 657317001320 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 657317001321 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 657317001322 putative active site [active] 657317001323 substrate binding site [chemical binding]; other site 657317001324 putative cosubstrate binding site; other site 657317001325 catalytic site [active] 657317001326 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 657317001327 substrate binding site [chemical binding]; other site 657317001328 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 657317001329 active site 657317001330 catalytic residues [active] 657317001331 metal binding site [ion binding]; metal-binding site 657317001332 primosome assembly protein PriA; Validated; Region: PRK05580 657317001333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317001334 ATP binding site [chemical binding]; other site 657317001335 putative Mg++ binding site [ion binding]; other site 657317001336 helicase superfamily c-terminal domain; Region: HELICc; smart00490 657317001337 ATP-binding site [chemical binding]; other site 657317001338 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 657317001339 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 657317001340 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 657317001341 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 657317001342 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 657317001343 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 657317001344 Bacterial PH domain; Region: DUF304; pfam03703 657317001345 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 657317001346 HSP70 interaction site [polypeptide binding]; other site 657317001347 Mitochondria Fission Protein Fis1, cytosolic domain; Region: Fis1; cd12212 657317001348 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 657317001349 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 657317001350 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 657317001351 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 657317001352 active site 657317001353 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 657317001354 Family of unknown function (DUF633); Region: DUF633; pfam04816 657317001355 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 657317001356 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 657317001357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317001358 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657317001359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317001360 DNA binding residues [nucleotide binding] 657317001361 DNA primase; Validated; Region: dnaG; PRK05667 657317001362 CHC2 zinc finger; Region: zf-CHC2; pfam01807 657317001363 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 657317001364 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 657317001365 active site 657317001366 metal binding site [ion binding]; metal-binding site 657317001367 interdomain interaction site; other site 657317001368 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 657317001369 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 657317001370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317001371 Zn2+ binding site [ion binding]; other site 657317001372 Mg2+ binding site [ion binding]; other site 657317001373 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 657317001374 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 657317001375 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657317001376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317001377 catalytic residue [active] 657317001378 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657317001379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317001380 Coenzyme A binding pocket [chemical binding]; other site 657317001381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317001382 non-specific DNA binding site [nucleotide binding]; other site 657317001383 salt bridge; other site 657317001384 sequence-specific DNA binding site [nucleotide binding]; other site 657317001385 Predicted transcriptional regulators [Transcription]; Region: COG1695 657317001386 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 657317001387 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 657317001388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317001389 Walker A/P-loop; other site 657317001390 ATP binding site [chemical binding]; other site 657317001391 Q-loop/lid; other site 657317001392 ABC transporter signature motif; other site 657317001393 Walker B; other site 657317001394 D-loop; other site 657317001395 H-loop/switch region; other site 657317001396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317001397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317001398 metal binding site [ion binding]; metal-binding site 657317001399 active site 657317001400 I-site; other site 657317001401 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317001402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 657317001403 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 657317001404 amidase catalytic site [active] 657317001405 Zn binding residues [ion binding]; other site 657317001406 substrate binding site [chemical binding]; other site 657317001407 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 657317001408 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 657317001409 homodimer interface [polypeptide binding]; other site 657317001410 substrate-cofactor binding pocket; other site 657317001411 catalytic residue [active] 657317001412 Predicted membrane protein [Function unknown]; Region: COG1511 657317001413 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 657317001414 FlxA-like protein; Region: FlxA; pfam14282 657317001415 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 657317001416 Predicted membrane protein [Function unknown]; Region: COG1511 657317001417 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 657317001418 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 657317001419 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 657317001420 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657317001421 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657317001422 EDD domain protein, DegV family; Region: DegV; TIGR00762 657317001423 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657317001424 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 657317001425 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 657317001426 active site 657317001427 metal binding site [ion binding]; metal-binding site 657317001428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657317001429 DNA-binding site [nucleotide binding]; DNA binding site 657317001430 RNA-binding motif; other site 657317001431 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 657317001432 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 657317001433 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 657317001434 NodB motif; other site 657317001435 active site 657317001436 catalytic site [active] 657317001437 Zn binding site [ion binding]; other site 657317001438 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 657317001439 4Fe-4S binding domain; Region: Fer4; pfam00037 657317001440 4Fe-4S binding domain; Region: Fer4; pfam00037 657317001441 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 657317001442 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657317001443 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657317001444 FtsX-like permease family; Region: FtsX; pfam02687 657317001445 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 657317001446 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 657317001447 HlyD family secretion protein; Region: HlyD_3; pfam13437 657317001448 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317001449 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317001450 Walker A/P-loop; other site 657317001451 ATP binding site [chemical binding]; other site 657317001452 Q-loop/lid; other site 657317001453 ABC transporter signature motif; other site 657317001454 Walker B; other site 657317001455 D-loop; other site 657317001456 H-loop/switch region; other site 657317001457 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 657317001458 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 657317001459 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 657317001460 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 657317001461 active site 657317001462 catalytic triad [active] 657317001463 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 657317001464 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 657317001465 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 657317001466 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 657317001467 Na binding site [ion binding]; other site 657317001468 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 657317001469 ATP cone domain; Region: ATP-cone; pfam03477 657317001470 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 657317001471 MarR family; Region: MarR_2; pfam12802 657317001472 MarR family; Region: MarR_2; cl17246 657317001473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317001474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317001475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317001476 Walker A/P-loop; other site 657317001477 ATP binding site [chemical binding]; other site 657317001478 Q-loop/lid; other site 657317001479 ABC transporter signature motif; other site 657317001480 Walker B; other site 657317001481 D-loop; other site 657317001482 H-loop/switch region; other site 657317001483 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317001484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317001485 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657317001486 Walker A/P-loop; other site 657317001487 ATP binding site [chemical binding]; other site 657317001488 Q-loop/lid; other site 657317001489 ABC transporter signature motif; other site 657317001490 Walker B; other site 657317001491 D-loop; other site 657317001492 H-loop/switch region; other site 657317001493 NAD synthetase; Reviewed; Region: nadE; PRK02628 657317001494 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 657317001495 multimer interface [polypeptide binding]; other site 657317001496 active site 657317001497 catalytic triad [active] 657317001498 protein interface 1 [polypeptide binding]; other site 657317001499 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 657317001500 homodimer interface [polypeptide binding]; other site 657317001501 NAD binding pocket [chemical binding]; other site 657317001502 ATP binding pocket [chemical binding]; other site 657317001503 Mg binding site [ion binding]; other site 657317001504 active-site loop [active] 657317001505 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 657317001506 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 657317001507 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 657317001508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317001509 ATP binding site [chemical binding]; other site 657317001510 putative Mg++ binding site [ion binding]; other site 657317001511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 657317001512 nucleotide binding region [chemical binding]; other site 657317001513 ATP-binding site [chemical binding]; other site 657317001514 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317001515 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317001516 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657317001517 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317001518 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317001519 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 657317001520 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317001521 active site 657317001522 DNA binding site [nucleotide binding] 657317001523 Int/Topo IB signature motif; other site 657317001524 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 657317001525 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657317001526 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317001527 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 657317001528 HsdM N-terminal domain; Region: HsdM_N; pfam12161 657317001529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 657317001530 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 657317001531 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 657317001532 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 657317001533 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 657317001534 HflX GTPase family; Region: HflX; cd01878 657317001535 G1 box; other site 657317001536 GTP/Mg2+ binding site [chemical binding]; other site 657317001537 Switch I region; other site 657317001538 G2 box; other site 657317001539 G3 box; other site 657317001540 Switch II region; other site 657317001541 G4 box; other site 657317001542 G5 box; other site 657317001543 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 657317001544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657317001545 binding surface 657317001546 TPR motif; other site 657317001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657317001548 binding surface 657317001549 TPR motif; other site 657317001550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657317001551 binding surface 657317001552 TPR motif; other site 657317001553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657317001554 binding surface 657317001555 TPR motif; other site 657317001556 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657317001557 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 657317001558 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317001559 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657317001560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317001561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317001562 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 657317001563 active site 657317001564 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317001565 SpoVA protein; Region: SpoVA; pfam03862 657317001566 stage V sporulation protein AD; Validated; Region: PRK08304 657317001567 stage V sporulation protein AD; Provisional; Region: PRK12404 657317001568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657317001569 active site 657317001570 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 657317001571 homodimer interaction site [polypeptide binding]; other site 657317001572 cofactor binding site; other site 657317001573 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 657317001574 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 657317001575 active site 657317001576 NAD binding site [chemical binding]; other site 657317001577 metal binding site [ion binding]; metal-binding site 657317001578 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317001579 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317001580 metal binding site [ion binding]; metal-binding site 657317001581 active site 657317001582 I-site; other site 657317001583 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 657317001584 Predicted transcriptional regulators [Transcription]; Region: COG1725 657317001585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317001586 DNA-binding site [nucleotide binding]; DNA binding site 657317001587 Predicted membrane protein [General function prediction only]; Region: COG4194 657317001588 Protein of unknown function (DUF419); Region: DUF419; pfam04237 657317001589 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 657317001590 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 657317001591 active site 657317001592 DNA binding site [nucleotide binding] 657317001593 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 657317001594 active site 657317001595 NTP binding site [chemical binding]; other site 657317001596 metal binding triad [ion binding]; metal-binding site 657317001597 antibiotic binding site [chemical binding]; other site 657317001598 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657317001599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317001600 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 657317001601 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 657317001602 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 657317001603 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 657317001604 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 657317001605 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 657317001606 Predicted transcriptional regulator [Transcription]; Region: COG4189 657317001607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657317001608 dimerization interface [polypeptide binding]; other site 657317001609 putative DNA binding site [nucleotide binding]; other site 657317001610 putative Zn2+ binding site [ion binding]; other site 657317001611 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 657317001612 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 657317001613 PYR/PP interface [polypeptide binding]; other site 657317001614 dimer interface [polypeptide binding]; other site 657317001615 TPP binding site [chemical binding]; other site 657317001616 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657317001617 transketolase; Reviewed; Region: PRK05899 657317001618 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 657317001619 TPP-binding site [chemical binding]; other site 657317001620 dimer interface [polypeptide binding]; other site 657317001621 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 657317001622 active site 657317001623 intersubunit interactions; other site 657317001624 catalytic residue [active] 657317001625 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 657317001626 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 657317001627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 657317001628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657317001629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657317001630 TPR motif; other site 657317001631 binding surface 657317001632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657317001633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317001634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317001635 metal binding site [ion binding]; metal-binding site 657317001636 active site 657317001637 I-site; other site 657317001638 AIR carboxylase; Region: AIRC; cl00310 657317001639 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 657317001640 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657317001641 active site 657317001642 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317001643 Int/Topo IB signature motif; other site 657317001644 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 657317001645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317001646 Walker A motif; other site 657317001647 ATP binding site [chemical binding]; other site 657317001648 Walker B motif; other site 657317001649 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 657317001650 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657317001651 Magnesium ion binding site [ion binding]; other site 657317001652 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 657317001653 ORF6N domain; Region: ORF6N; pfam10543 657317001654 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 657317001655 Mg binding site [ion binding]; other site 657317001656 nucleotide binding site [chemical binding]; other site 657317001657 putative protofilament interface [polypeptide binding]; other site 657317001658 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 657317001659 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 657317001660 CysD dimerization site [polypeptide binding]; other site 657317001661 G1 box; other site 657317001662 putative GEF interaction site [polypeptide binding]; other site 657317001663 GTP/Mg2+ binding site [chemical binding]; other site 657317001664 Switch I region; other site 657317001665 G2 box; other site 657317001666 G3 box; other site 657317001667 Switch II region; other site 657317001668 G4 box; other site 657317001669 G5 box; other site 657317001670 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 657317001671 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 657317001672 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 657317001673 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 657317001674 Active Sites [active] 657317001675 Ferredoxin [Energy production and conversion]; Region: COG1146 657317001676 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 657317001677 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 657317001678 L-aspartate oxidase; Provisional; Region: PRK06175 657317001679 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 657317001680 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 657317001681 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 657317001682 Walker A/P-loop; other site 657317001683 ATP binding site [chemical binding]; other site 657317001684 Q-loop/lid; other site 657317001685 ABC transporter signature motif; other site 657317001686 Walker B; other site 657317001687 D-loop; other site 657317001688 H-loop/switch region; other site 657317001689 TOBE domain; Region: TOBE_2; pfam08402 657317001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317001691 dimer interface [polypeptide binding]; other site 657317001692 conserved gate region; other site 657317001693 ABC-ATPase subunit interface; other site 657317001694 sulfate transport protein; Provisional; Region: cysT; CHL00187 657317001695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317001696 dimer interface [polypeptide binding]; other site 657317001697 conserved gate region; other site 657317001698 putative PBP binding loops; other site 657317001699 ABC-ATPase subunit interface; other site 657317001700 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 657317001701 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657317001702 substrate binding pocket [chemical binding]; other site 657317001703 membrane-bound complex binding site; other site 657317001704 hinge residues; other site 657317001705 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 657317001706 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 657317001707 dimer interface [polypeptide binding]; other site 657317001708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317001709 catalytic residue [active] 657317001710 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 657317001711 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 657317001712 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 657317001713 heterodimer interface [polypeptide binding]; other site 657317001714 active site 657317001715 FMN binding site [chemical binding]; other site 657317001716 homodimer interface [polypeptide binding]; other site 657317001717 substrate binding site [chemical binding]; other site 657317001718 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 657317001719 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 657317001720 FAD binding pocket [chemical binding]; other site 657317001721 FAD binding motif [chemical binding]; other site 657317001722 phosphate binding motif [ion binding]; other site 657317001723 beta-alpha-beta structure motif; other site 657317001724 NAD binding pocket [chemical binding]; other site 657317001725 Iron coordination center [ion binding]; other site 657317001726 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 657317001727 active site 657317001728 dimer interface [polypeptide binding]; other site 657317001729 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 657317001730 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 657317001731 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 657317001732 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 657317001733 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 657317001734 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 657317001735 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 657317001736 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 657317001737 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 657317001738 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 657317001739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 657317001740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657317001741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 657317001742 active site 657317001743 catalytic tetrad [active] 657317001744 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 657317001745 tetramerization interface [polypeptide binding]; other site 657317001746 active site 657317001747 pantoate--beta-alanine ligase; Region: panC; TIGR00018 657317001748 Pantoate-beta-alanine ligase; Region: PanC; cd00560 657317001749 active site 657317001750 ATP-binding site [chemical binding]; other site 657317001751 pantoate-binding site; other site 657317001752 HXXH motif; other site 657317001753 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 657317001754 oligomerization interface [polypeptide binding]; other site 657317001755 active site 657317001756 metal binding site [ion binding]; metal-binding site 657317001757 Uncharacterized conserved protein [Function unknown]; Region: COG5495 657317001758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657317001759 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 657317001760 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317001761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317001762 Zn2+ binding site [ion binding]; other site 657317001763 Mg2+ binding site [ion binding]; other site 657317001764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317001765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317001766 metal binding site [ion binding]; metal-binding site 657317001767 active site 657317001768 I-site; other site 657317001769 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 657317001770 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657317001771 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 657317001772 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 657317001773 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 657317001774 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 657317001775 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657317001776 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 657317001777 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 657317001778 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 657317001779 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 657317001780 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 657317001781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657317001782 active site 657317001783 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 657317001784 Ligand binding site; other site 657317001785 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 657317001786 metal-binding site 657317001787 Bacterial transcriptional activator domain; Region: BTAD; smart01043 657317001788 Response regulator receiver domain; Region: Response_reg; pfam00072 657317001789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317001790 active site 657317001791 phosphorylation site [posttranslational modification] 657317001792 intermolecular recognition site; other site 657317001793 dimerization interface [polypeptide binding]; other site 657317001794 LytTr DNA-binding domain; Region: LytTR; pfam04397 657317001795 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 657317001796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 657317001797 Mg2+ binding site [ion binding]; other site 657317001798 G-X-G motif; other site 657317001799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317001800 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 657317001801 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 657317001802 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 657317001803 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 657317001804 dimer interface [polypeptide binding]; other site 657317001805 substrate binding site [chemical binding]; other site 657317001806 ATP binding site [chemical binding]; other site 657317001807 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 657317001808 thiamine phosphate binding site [chemical binding]; other site 657317001809 active site 657317001810 pyrophosphate binding site [ion binding]; other site 657317001811 dihydrodipicolinate reductase; Provisional; Region: PRK00048 657317001812 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 657317001813 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 657317001814 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 657317001815 dihydrodipicolinate synthase; Region: dapA; TIGR00674 657317001816 dimer interface [polypeptide binding]; other site 657317001817 active site 657317001818 catalytic residue [active] 657317001819 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317001820 Walker A motif; other site 657317001821 ATP binding site [chemical binding]; other site 657317001822 Walker B motif; other site 657317001823 single-stranded DNA-binding protein; Provisional; Region: PRK05813 657317001824 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657317001825 dimer interface [polypeptide binding]; other site 657317001826 ssDNA binding site [nucleotide binding]; other site 657317001827 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657317001828 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 657317001829 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 657317001830 G1 box; other site 657317001831 putative GEF interaction site [polypeptide binding]; other site 657317001832 GTP/Mg2+ binding site [chemical binding]; other site 657317001833 Switch I region; other site 657317001834 G2 box; other site 657317001835 G3 box; other site 657317001836 Switch II region; other site 657317001837 G4 box; other site 657317001838 G5 box; other site 657317001839 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 657317001840 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 657317001841 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 657317001842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317001843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317001844 homodimer interface [polypeptide binding]; other site 657317001845 catalytic residue [active] 657317001846 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 657317001847 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 657317001848 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 657317001849 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 657317001850 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 657317001851 active site 657317001852 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 657317001853 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 657317001854 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 657317001855 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 657317001856 active site 657317001857 Type II/IV secretion system protein; Region: T2SE; pfam00437 657317001858 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317001859 Walker A motif; other site 657317001860 ATP binding site [chemical binding]; other site 657317001861 Walker B motif; other site 657317001862 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 657317001863 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657317001864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317001865 catalytic residue [active] 657317001866 recombination factor protein RarA; Reviewed; Region: PRK13342 657317001867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317001868 Walker A motif; other site 657317001869 ATP binding site [chemical binding]; other site 657317001870 Walker B motif; other site 657317001871 arginine finger; other site 657317001872 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 657317001873 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 657317001874 N- and C-terminal domain interface [polypeptide binding]; other site 657317001875 D-xylulose kinase; Region: XylB; TIGR01312 657317001876 active site 657317001877 MgATP binding site [chemical binding]; other site 657317001878 catalytic site [active] 657317001879 metal binding site [ion binding]; metal-binding site 657317001880 xylulose binding site [chemical binding]; other site 657317001881 homodimer interface [polypeptide binding]; other site 657317001882 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 657317001883 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 657317001884 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657317001885 substrate binding site [chemical binding]; other site 657317001886 trimer interface [polypeptide binding]; other site 657317001887 Mn binding site [ion binding]; other site 657317001888 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317001889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317001890 DNA binding site [nucleotide binding] 657317001891 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317001892 ligand binding site [chemical binding]; other site 657317001893 dimerization interface [polypeptide binding]; other site 657317001894 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 657317001895 Clp amino terminal domain; Region: Clp_N; pfam02861 657317001896 Clp amino terminal domain; Region: Clp_N; pfam02861 657317001897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317001898 Walker A motif; other site 657317001899 ATP binding site [chemical binding]; other site 657317001900 Walker B motif; other site 657317001901 arginine finger; other site 657317001902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317001903 Walker A motif; other site 657317001904 ATP binding site [chemical binding]; other site 657317001905 Walker B motif; other site 657317001906 arginine finger; other site 657317001907 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 657317001908 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 657317001909 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 657317001910 synthetase active site [active] 657317001911 NTP binding site [chemical binding]; other site 657317001912 metal binding site [ion binding]; metal-binding site 657317001913 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 657317001914 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 657317001915 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 657317001916 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 657317001917 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657317001918 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 657317001919 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 657317001920 transmembrane helices; other site 657317001921 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657317001922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317001923 motif II; other site 657317001924 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 657317001925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317001926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317001927 DNA binding residues [nucleotide binding] 657317001928 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 657317001929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317001930 ATP binding site [chemical binding]; other site 657317001931 Mg2+ binding site [ion binding]; other site 657317001932 G-X-G motif; other site 657317001933 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 657317001934 anti sigma factor interaction site; other site 657317001935 regulatory phosphorylation site [posttranslational modification]; other site 657317001936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657317001937 binding surface 657317001938 TPR motif; other site 657317001939 Protein of unknown function (DUF342); Region: DUF342; pfam03961 657317001940 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 657317001941 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 657317001942 active site 657317001943 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 657317001944 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657317001945 active site 657317001946 HIGH motif; other site 657317001947 nucleotide binding site [chemical binding]; other site 657317001948 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657317001949 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 657317001950 active site 657317001951 KMSKS motif; other site 657317001952 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 657317001953 tRNA binding surface [nucleotide binding]; other site 657317001954 anticodon binding site; other site 657317001955 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 657317001956 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 657317001957 RelB antitoxin; Region: RelB; cl01171 657317001958 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 657317001959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 657317001960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657317001961 Predicted dehydrogenase [General function prediction only]; Region: COG0579 657317001962 hydroxyglutarate oxidase; Provisional; Region: PRK11728 657317001963 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 657317001964 glycerol kinase; Provisional; Region: glpK; PRK00047 657317001965 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 657317001966 N- and C-terminal domain interface [polypeptide binding]; other site 657317001967 active site 657317001968 MgATP binding site [chemical binding]; other site 657317001969 catalytic site [active] 657317001970 metal binding site [ion binding]; metal-binding site 657317001971 glycerol binding site [chemical binding]; other site 657317001972 homotetramer interface [polypeptide binding]; other site 657317001973 homodimer interface [polypeptide binding]; other site 657317001974 FBP binding site [chemical binding]; other site 657317001975 protein IIAGlc interface [polypeptide binding]; other site 657317001976 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 657317001977 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 657317001978 Protein export membrane protein; Region: SecD_SecF; cl14618 657317001979 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 657317001980 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 657317001981 NodB motif; other site 657317001982 active site 657317001983 catalytic site [active] 657317001984 metal binding site [ion binding]; metal-binding site 657317001985 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 657317001986 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 657317001987 S-ribosylhomocysteinase; Provisional; Region: PRK02260 657317001988 oligoendopeptidase F; Region: pepF; TIGR00181 657317001989 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 657317001990 active site 657317001991 Zn binding site [ion binding]; other site 657317001992 carbamate kinase; Reviewed; Region: PRK12686 657317001993 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 657317001994 putative substrate binding site [chemical binding]; other site 657317001995 nucleotide binding site [chemical binding]; other site 657317001996 nucleotide binding site [chemical binding]; other site 657317001997 homodimer interface [polypeptide binding]; other site 657317001998 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 657317001999 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 657317002000 protein binding site [polypeptide binding]; other site 657317002001 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 657317002002 substrate binding site; other site 657317002003 dimerization interface; other site 657317002004 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 657317002005 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 657317002006 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 657317002007 active site 657317002008 substrate binding site [chemical binding]; other site 657317002009 metal binding site [ion binding]; metal-binding site 657317002010 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657317002011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657317002012 active site 657317002013 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657317002014 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 657317002015 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 657317002016 inhibitor-cofactor binding pocket; inhibition site 657317002017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317002018 catalytic residue [active] 657317002019 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 657317002020 TRC8 N-terminal domain; Region: TRC8_N; pfam13705 657317002021 CoA binding domain; Region: CoA_binding; cl17356 657317002022 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 657317002023 NAD(P) binding site [chemical binding]; other site 657317002024 homodimer interface [polypeptide binding]; other site 657317002025 substrate binding site [chemical binding]; other site 657317002026 active site 657317002027 Predicted membrane protein [Function unknown]; Region: COG2246 657317002028 GtrA-like protein; Region: GtrA; pfam04138 657317002029 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 657317002030 Acyltransferase family; Region: Acyl_transf_3; pfam01757 657317002031 Predicted membrane protein [Function unknown]; Region: COG2246 657317002032 GtrA-like protein; Region: GtrA; pfam04138 657317002033 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 657317002034 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 657317002035 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002036 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 657317002038 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 657317002039 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 657317002040 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657317002041 active site 657317002042 metal binding site [ion binding]; metal-binding site 657317002043 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 657317002044 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 657317002045 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 657317002046 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002047 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002048 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002049 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 657317002050 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002051 Clostridial hydrophobic W; Region: ChW; pfam07538 657317002052 Sulfatase; Region: Sulfatase; cl17466 657317002053 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657317002054 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 657317002055 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 657317002056 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657317002057 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 657317002058 Probable Catalytic site; other site 657317002059 metal-binding site 657317002060 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 657317002061 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 657317002062 Probable Catalytic site; other site 657317002063 metal-binding site 657317002064 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 657317002065 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 657317002066 Walker A/P-loop; other site 657317002067 ATP binding site [chemical binding]; other site 657317002068 Q-loop/lid; other site 657317002069 ABC transporter signature motif; other site 657317002070 Walker B; other site 657317002071 D-loop; other site 657317002072 H-loop/switch region; other site 657317002073 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 657317002074 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 657317002075 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657317002076 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 657317002077 Probable Catalytic site; other site 657317002078 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657317002079 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657317002080 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657317002081 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657317002082 Transcriptional regulator [Transcription]; Region: LytR; COG1316 657317002083 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 657317002084 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 657317002085 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 657317002086 NADP binding site [chemical binding]; other site 657317002087 active site 657317002088 putative substrate binding site [chemical binding]; other site 657317002089 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 657317002090 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 657317002091 NAD binding site [chemical binding]; other site 657317002092 substrate binding site [chemical binding]; other site 657317002093 homodimer interface [polypeptide binding]; other site 657317002094 active site 657317002095 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 657317002096 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 657317002097 substrate binding site; other site 657317002098 tetramer interface; other site 657317002099 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 657317002100 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 657317002101 DNA binding residues [nucleotide binding] 657317002102 dimer interface [polypeptide binding]; other site 657317002103 Methyltransferase domain; Region: Methyltransf_31; pfam13847 657317002104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317002105 S-adenosylmethionine binding site [chemical binding]; other site 657317002106 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 657317002107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657317002108 UDP-galactopyranose mutase; Region: GLF; pfam03275 657317002109 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 657317002110 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 657317002111 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657317002112 catalytic residue [active] 657317002113 Phosphopantetheine attachment site; Region: PP-binding; cl09936 657317002114 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657317002115 AMP-binding enzyme; Region: AMP-binding; pfam00501 657317002116 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 657317002117 acyl-activating enzyme (AAE) consensus motif; other site 657317002118 AMP binding site [chemical binding]; other site 657317002119 active site 657317002120 CoA binding site [chemical binding]; other site 657317002121 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 657317002122 Ligand binding site; other site 657317002123 Putative Catalytic site; other site 657317002124 DXD motif; other site 657317002125 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 657317002126 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 657317002127 active site 657317002128 substrate binding site [chemical binding]; other site 657317002129 metal binding site [ion binding]; metal-binding site 657317002130 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 657317002131 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657317002132 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 657317002133 Transcriptional regulator [Transcription]; Region: LytR; COG1316 657317002134 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 657317002135 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317002136 ParA/MinD ATPase like; Region: ParA; pfam10609 657317002137 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 657317002138 Chain length determinant protein; Region: Wzz; cl15801 657317002139 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 657317002140 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657317002141 active site 657317002142 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657317002143 active site 657317002144 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657317002145 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657317002146 active site 657317002147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 657317002148 YbbR-like protein; Region: YbbR; pfam07949 657317002149 Uncharacterized conserved protein [Function unknown]; Region: COG1624 657317002150 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 657317002151 flagellar operon protein TIGR03826; Region: YvyF 657317002152 rod shape-determining protein MreB; Provisional; Region: PRK13930 657317002153 MreB and similar proteins; Region: MreB_like; cd10225 657317002154 nucleotide binding site [chemical binding]; other site 657317002155 Mg binding site [ion binding]; other site 657317002156 putative protofilament interaction site [polypeptide binding]; other site 657317002157 RodZ interaction site [polypeptide binding]; other site 657317002158 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 657317002159 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657317002160 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 657317002161 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 657317002162 excinuclease ABC subunit B; Provisional; Region: PRK05298 657317002163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317002164 ATP binding site [chemical binding]; other site 657317002165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317002166 nucleotide binding region [chemical binding]; other site 657317002167 ATP-binding site [chemical binding]; other site 657317002168 Ultra-violet resistance protein B; Region: UvrB; pfam12344 657317002169 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 657317002170 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 657317002171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317002172 nucleotide binding region [chemical binding]; other site 657317002173 ATP-binding site [chemical binding]; other site 657317002174 SEC-C motif; Region: SEC-C; pfam02810 657317002175 TSCPD domain; Region: TSCPD; cl14834 657317002176 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 657317002177 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 657317002178 NAD binding site [chemical binding]; other site 657317002179 aspartate kinase; Reviewed; Region: PRK09034 657317002180 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 657317002181 nucleotide binding site [chemical binding]; other site 657317002182 substrate binding site [chemical binding]; other site 657317002183 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 657317002184 allosteric regulatory residue; other site 657317002185 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 657317002186 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 657317002187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657317002188 active site 657317002189 metal binding site [ion binding]; metal-binding site 657317002190 homotetramer interface [polypeptide binding]; other site 657317002191 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 657317002192 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657317002193 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 657317002194 histidinol-phosphatase; Provisional; Region: PRK07328 657317002195 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 657317002196 active site 657317002197 dimer interface [polypeptide binding]; other site 657317002198 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 657317002199 TrkA-N domain; Region: TrkA_N; pfam02254 657317002200 TrkA-C domain; Region: TrkA_C; pfam02080 657317002201 TrkA-N domain; Region: TrkA_N; pfam02254 657317002202 TrkA-C domain; Region: TrkA_C; pfam02080 657317002203 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 657317002204 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 657317002205 Repair protein; Region: Repair_PSII; pfam04536 657317002206 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317002207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317002208 Zn2+ binding site [ion binding]; other site 657317002209 Mg2+ binding site [ion binding]; other site 657317002210 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 657317002211 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657317002212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002213 Walker A/P-loop; other site 657317002214 ATP binding site [chemical binding]; other site 657317002215 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317002216 ABC transporter; Region: ABC_tran_2; pfam12848 657317002217 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317002218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657317002219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317002220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317002221 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317002222 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 657317002223 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 657317002224 catalytic domain interface [polypeptide binding]; other site 657317002225 putative homodimer interface [polypeptide binding]; other site 657317002226 Protein of unknown function, DUF608; Region: DUF608; pfam04685 657317002227 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 657317002228 Cupin domain; Region: Cupin_2; pfam07883 657317002229 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657317002230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317002231 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 657317002232 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657317002233 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657317002234 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 657317002235 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317002236 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317002237 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 657317002238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317002239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317002240 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 657317002241 putative active site [active] 657317002242 putative metal binding site [ion binding]; other site 657317002243 Domain of unknown function (DUF303); Region: DUF303; pfam03629 657317002244 Right handed beta helix region; Region: Beta_helix; pfam13229 657317002245 Right handed beta helix region; Region: Beta_helix; pfam13229 657317002246 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 657317002247 active site 657317002248 catalytic triad [active] 657317002249 oxyanion hole [active] 657317002250 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 657317002251 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657317002252 substrate binding site [chemical binding]; other site 657317002253 ATP binding site [chemical binding]; other site 657317002254 Glucuronate isomerase; Region: UxaC; pfam02614 657317002255 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 657317002256 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 657317002257 active site 657317002258 intersubunit interface [polypeptide binding]; other site 657317002259 catalytic residue [active] 657317002260 KDPG and KHG aldolase; Region: Aldolase; cl17259 657317002261 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 657317002262 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 657317002263 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 657317002264 mannonate dehydratase; Provisional; Region: PRK03906 657317002265 mannonate dehydratase; Region: uxuA; TIGR00695 657317002266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317002268 dimer interface [polypeptide binding]; other site 657317002269 conserved gate region; other site 657317002270 putative PBP binding loops; other site 657317002271 ABC-ATPase subunit interface; other site 657317002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 657317002273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317002274 dimer interface [polypeptide binding]; other site 657317002275 conserved gate region; other site 657317002276 putative PBP binding loops; other site 657317002277 ABC-ATPase subunit interface; other site 657317002278 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317002279 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317002280 Response regulator receiver domain; Region: Response_reg; pfam00072 657317002281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317002282 active site 657317002283 phosphorylation site [posttranslational modification] 657317002284 intermolecular recognition site; other site 657317002285 dimerization interface [polypeptide binding]; other site 657317002286 Helix-turn-helix domain; Region: HTH_18; pfam12833 657317002287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317002288 Protein of unknown function, DUF624; Region: DUF624; pfam04854 657317002289 enolase; Provisional; Region: eno; PRK00077 657317002290 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 657317002291 dimer interface [polypeptide binding]; other site 657317002292 metal binding site [ion binding]; metal-binding site 657317002293 substrate binding pocket [chemical binding]; other site 657317002294 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 657317002295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317002296 salt bridge; other site 657317002297 non-specific DNA binding site [nucleotide binding]; other site 657317002298 sequence-specific DNA binding site [nucleotide binding]; other site 657317002299 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 657317002300 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 657317002301 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 657317002302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317002303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317002304 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 657317002305 Walker A/P-loop; other site 657317002306 ATP binding site [chemical binding]; other site 657317002307 Q-loop/lid; other site 657317002308 ABC transporter signature motif; other site 657317002309 Walker B; other site 657317002310 D-loop; other site 657317002311 H-loop/switch region; other site 657317002312 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317002313 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317002314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002315 Walker A/P-loop; other site 657317002316 ATP binding site [chemical binding]; other site 657317002317 Q-loop/lid; other site 657317002318 ABC transporter signature motif; other site 657317002319 Walker B; other site 657317002320 D-loop; other site 657317002321 H-loop/switch region; other site 657317002322 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 657317002323 dimer interface [polypeptide binding]; other site 657317002324 ADP-ribose binding site [chemical binding]; other site 657317002325 active site 657317002326 nudix motif; other site 657317002327 metal binding site [ion binding]; metal-binding site 657317002328 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 657317002329 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 657317002330 active site 657317002331 Chorismate mutase type II; Region: CM_2; cl00693 657317002332 shikimate kinase; Reviewed; Region: aroK; PRK00131 657317002333 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 657317002334 ADP binding site [chemical binding]; other site 657317002335 magnesium binding site [ion binding]; other site 657317002336 putative shikimate binding site; other site 657317002337 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 657317002338 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 657317002339 DctM-like transporters; Region: DctM; pfam06808 657317002340 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 657317002341 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 657317002342 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 657317002343 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 657317002344 active site 657317002345 catalytic residue [active] 657317002346 dimer interface [polypeptide binding]; other site 657317002347 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 657317002348 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 657317002349 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 657317002350 shikimate binding site; other site 657317002351 NAD(P) binding site [chemical binding]; other site 657317002352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317002353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317002354 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 657317002355 dimerization interface [polypeptide binding]; other site 657317002356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317002357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317002358 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 657317002359 putative dimerization interface [polypeptide binding]; other site 657317002360 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 657317002361 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 657317002362 active site 657317002363 FMN binding site [chemical binding]; other site 657317002364 substrate binding site [chemical binding]; other site 657317002365 putative catalytic residue [active] 657317002366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 657317002367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657317002368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657317002369 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 657317002370 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 657317002371 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 657317002372 shikimate binding site; other site 657317002373 NAD(P) binding site [chemical binding]; other site 657317002374 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 657317002375 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 657317002376 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 657317002377 nudix motif; other site 657317002378 chaperone protein DnaJ; Provisional; Region: PRK14299 657317002379 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 657317002380 HSP70 interaction site [polypeptide binding]; other site 657317002381 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 657317002382 substrate binding site [polypeptide binding]; other site 657317002383 dimer interface [polypeptide binding]; other site 657317002384 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 657317002385 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 657317002386 putative dimer interface [polypeptide binding]; other site 657317002387 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 657317002388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002389 Walker A/P-loop; other site 657317002390 ATP binding site [chemical binding]; other site 657317002391 Q-loop/lid; other site 657317002392 ABC transporter signature motif; other site 657317002393 Walker B; other site 657317002394 D-loop; other site 657317002395 H-loop/switch region; other site 657317002396 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 657317002397 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317002398 Walker A/P-loop; other site 657317002399 ATP binding site [chemical binding]; other site 657317002400 Q-loop/lid; other site 657317002401 ABC transporter signature motif; other site 657317002402 Walker B; other site 657317002403 D-loop; other site 657317002404 H-loop/switch region; other site 657317002405 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 657317002406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317002407 active site 657317002408 DNA binding site [nucleotide binding] 657317002409 Int/Topo IB signature motif; other site 657317002410 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657317002411 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 657317002412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317002413 catalytic residue [active] 657317002414 Accessory gene regulator B; Region: AgrB; pfam04647 657317002415 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 657317002416 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317002417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317002418 active site 657317002419 phosphorylation site [posttranslational modification] 657317002420 intermolecular recognition site; other site 657317002421 dimerization interface [polypeptide binding]; other site 657317002422 LytTr DNA-binding domain; Region: LytTR; pfam04397 657317002423 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 657317002424 PIN domain; Region: PIN_3; pfam13470 657317002425 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 657317002426 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657317002427 LrgB-like family; Region: LrgB; pfam04172 657317002428 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 657317002429 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 657317002430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317002431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317002432 metal binding site [ion binding]; metal-binding site 657317002433 active site 657317002434 I-site; other site 657317002435 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317002436 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 657317002437 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 657317002438 gamma subunit interface [polypeptide binding]; other site 657317002439 epsilon subunit interface [polypeptide binding]; other site 657317002440 LBP interface [polypeptide binding]; other site 657317002441 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 657317002442 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 657317002443 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 657317002444 alpha subunit interaction interface [polypeptide binding]; other site 657317002445 Walker A motif; other site 657317002446 ATP binding site [chemical binding]; other site 657317002447 Walker B motif; other site 657317002448 inhibitor binding site; inhibition site 657317002449 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 657317002450 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 657317002451 core domain interface [polypeptide binding]; other site 657317002452 delta subunit interface [polypeptide binding]; other site 657317002453 epsilon subunit interface [polypeptide binding]; other site 657317002454 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 657317002455 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 657317002456 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 657317002457 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 657317002458 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 657317002459 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 657317002460 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 657317002461 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 657317002462 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 657317002463 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 657317002464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657317002465 active site 657317002466 metal binding site [ion binding]; metal-binding site 657317002467 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657317002468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002469 Walker A/P-loop; other site 657317002470 ATP binding site [chemical binding]; other site 657317002471 Q-loop/lid; other site 657317002472 ABC transporter signature motif; other site 657317002473 Walker B; other site 657317002474 D-loop; other site 657317002475 H-loop/switch region; other site 657317002476 Predicted transcriptional regulators [Transcription]; Region: COG1725 657317002477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317002478 DNA-binding site [nucleotide binding]; DNA binding site 657317002479 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657317002480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317002481 Walker A/P-loop; other site 657317002482 ATP binding site [chemical binding]; other site 657317002483 Q-loop/lid; other site 657317002484 ABC transporter signature motif; other site 657317002485 Walker B; other site 657317002486 D-loop; other site 657317002487 H-loop/switch region; other site 657317002488 dihydroorotase; Validated; Region: pyrC; PRK09357 657317002489 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 657317002490 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 657317002491 active site 657317002492 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 657317002493 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317002494 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317002495 metal binding site [ion binding]; metal-binding site 657317002496 active site 657317002497 I-site; other site 657317002498 PAS domain; Region: PAS_9; pfam13426 657317002499 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 657317002500 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 657317002501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317002502 S-adenosylmethionine binding site [chemical binding]; other site 657317002503 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 657317002504 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 657317002505 generic binding surface II; other site 657317002506 generic binding surface I; other site 657317002507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317002508 Zn2+ binding site [ion binding]; other site 657317002509 Mg2+ binding site [ion binding]; other site 657317002510 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 657317002511 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 657317002512 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 657317002513 protein binding site [polypeptide binding]; other site 657317002514 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 657317002515 MutS domain III; Region: MutS_III; pfam05192 657317002516 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 657317002517 Walker A/P-loop; other site 657317002518 ATP binding site [chemical binding]; other site 657317002519 Q-loop/lid; other site 657317002520 ABC transporter signature motif; other site 657317002521 Walker B; other site 657317002522 D-loop; other site 657317002523 H-loop/switch region; other site 657317002524 Smr domain; Region: Smr; pfam01713 657317002525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317002526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317002527 active site 657317002528 phosphorylation site [posttranslational modification] 657317002529 intermolecular recognition site; other site 657317002530 dimerization interface [polypeptide binding]; other site 657317002531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317002532 DNA binding site [nucleotide binding] 657317002533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317002534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317002535 dimerization interface [polypeptide binding]; other site 657317002536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317002537 dimer interface [polypeptide binding]; other site 657317002538 phosphorylation site [posttranslational modification] 657317002539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317002540 ATP binding site [chemical binding]; other site 657317002541 Mg2+ binding site [ion binding]; other site 657317002542 G-X-G motif; other site 657317002543 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 657317002544 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 657317002545 dimer interface [polypeptide binding]; other site 657317002546 anticodon binding site; other site 657317002547 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 657317002548 homodimer interface [polypeptide binding]; other site 657317002549 motif 1; other site 657317002550 active site 657317002551 motif 2; other site 657317002552 GAD domain; Region: GAD; pfam02938 657317002553 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657317002554 active site 657317002555 motif 3; other site 657317002556 histidyl-tRNA synthetase; Region: hisS; TIGR00442 657317002557 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 657317002558 dimer interface [polypeptide binding]; other site 657317002559 motif 1; other site 657317002560 active site 657317002561 motif 2; other site 657317002562 motif 3; other site 657317002563 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 657317002564 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 657317002565 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 657317002566 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657317002567 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657317002568 active site turn [active] 657317002569 phosphorylation site [posttranslational modification] 657317002570 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657317002571 HPr interaction site; other site 657317002572 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657317002573 active site 657317002574 phosphorylation site [posttranslational modification] 657317002575 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 657317002576 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 657317002577 active site 657317002578 dimer interface [polypeptide binding]; other site 657317002579 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 657317002580 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 657317002581 active site 657317002582 trimer interface [polypeptide binding]; other site 657317002583 allosteric site; other site 657317002584 active site lid [active] 657317002585 hexamer (dimer of trimers) interface [polypeptide binding]; other site 657317002586 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 657317002587 active site 657317002588 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 657317002589 RelB antitoxin; Region: RelB; cl01171 657317002590 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 657317002591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657317002592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002593 AAA domain; Region: AAA_21; pfam13304 657317002594 Walker A/P-loop; other site 657317002595 ATP binding site [chemical binding]; other site 657317002596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002597 Q-loop/lid; other site 657317002598 ABC transporter signature motif; other site 657317002599 Walker B; other site 657317002600 D-loop; other site 657317002601 H-loop/switch region; other site 657317002602 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 657317002603 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317002604 active site 657317002605 DNA binding site [nucleotide binding] 657317002606 Int/Topo IB signature motif; other site 657317002607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657317002608 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317002609 catalytic residue [active] 657317002610 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 657317002611 putative aminotransferase; Provisional; Region: PRK09105 657317002612 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 657317002613 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 657317002614 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657317002615 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657317002616 Transposase; Region: HTH_Tnp_1; cl17663 657317002617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002619 Walker A/P-loop; other site 657317002620 Walker A/P-loop; other site 657317002621 ATP binding site [chemical binding]; other site 657317002622 ATP binding site [chemical binding]; other site 657317002623 AAA domain; Region: AAA_21; pfam13304 657317002624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657317002625 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657317002626 putative sugar binding sites [chemical binding]; other site 657317002627 Q-X-W motif; other site 657317002628 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657317002629 putative sugar binding sites [chemical binding]; other site 657317002630 Q-X-W motif; other site 657317002631 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 657317002632 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 657317002633 putative sugar binding sites [chemical binding]; other site 657317002634 Q-X-W motif; other site 657317002635 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 657317002636 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 657317002637 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657317002638 4Fe-4S binding domain; Region: Fer4; cl02805 657317002639 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 657317002640 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 657317002641 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657317002642 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 657317002643 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 657317002644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657317002645 active site 657317002646 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 657317002647 putative trimer interface [polypeptide binding]; other site 657317002648 putative CoA binding site [chemical binding]; other site 657317002649 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657317002650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657317002651 active site 657317002652 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 657317002653 active site 657317002654 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 657317002655 Bacterial sugar transferase; Region: Bac_transf; pfam02397 657317002656 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 657317002657 active site 657317002658 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 657317002659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002660 Walker A/P-loop; other site 657317002661 ATP binding site [chemical binding]; other site 657317002662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002663 Walker B; other site 657317002664 D-loop; other site 657317002665 H-loop/switch region; other site 657317002666 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 657317002667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317002668 FeS/SAM binding site; other site 657317002669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657317002670 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 657317002671 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657317002672 nucleotide binding site [chemical binding]; other site 657317002673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657317002674 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657317002675 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 657317002676 active site 657317002677 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 657317002678 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657317002679 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657317002680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657317002681 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 657317002682 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 657317002683 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657317002684 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 657317002685 30S subunit binding site; other site 657317002686 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657317002687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317002688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317002689 ABC transporter; Region: ABC_tran_2; pfam12848 657317002690 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317002691 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 657317002692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317002693 Walker A motif; other site 657317002694 ATP binding site [chemical binding]; other site 657317002695 Walker B motif; other site 657317002696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317002697 dimer interface [polypeptide binding]; other site 657317002698 phosphorylation site [posttranslational modification] 657317002699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317002700 ATP binding site [chemical binding]; other site 657317002701 Mg2+ binding site [ion binding]; other site 657317002702 G-X-G motif; other site 657317002703 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317002704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317002705 active site 657317002706 phosphorylation site [posttranslational modification] 657317002707 intermolecular recognition site; other site 657317002708 dimerization interface [polypeptide binding]; other site 657317002709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317002710 DNA binding site [nucleotide binding] 657317002711 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 657317002712 PhoU domain; Region: PhoU; pfam01895 657317002713 PhoU domain; Region: PhoU; pfam01895 657317002714 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 657317002715 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 657317002716 Walker A/P-loop; other site 657317002717 ATP binding site [chemical binding]; other site 657317002718 Q-loop/lid; other site 657317002719 ABC transporter signature motif; other site 657317002720 Walker B; other site 657317002721 D-loop; other site 657317002722 H-loop/switch region; other site 657317002723 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 657317002724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317002725 DNA-binding site [nucleotide binding]; DNA binding site 657317002726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317002727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317002728 homodimer interface [polypeptide binding]; other site 657317002729 catalytic residue [active] 657317002730 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 657317002731 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 657317002732 active site 657317002733 multimer interface [polypeptide binding]; other site 657317002734 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 657317002735 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 657317002736 predicted active site [active] 657317002737 catalytic triad [active] 657317002738 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 657317002739 active site 657317002740 NTP binding site [chemical binding]; other site 657317002741 metal binding triad [ion binding]; metal-binding site 657317002742 antibiotic binding site [chemical binding]; other site 657317002743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317002744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317002745 dimer interface [polypeptide binding]; other site 657317002746 phosphorylation site [posttranslational modification] 657317002747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317002748 ATP binding site [chemical binding]; other site 657317002749 Mg2+ binding site [ion binding]; other site 657317002750 G-X-G motif; other site 657317002751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317002752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317002753 active site 657317002754 phosphorylation site [posttranslational modification] 657317002755 intermolecular recognition site; other site 657317002756 dimerization interface [polypeptide binding]; other site 657317002757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317002758 DNA binding site [nucleotide binding] 657317002759 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 657317002760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317002761 dimer interface [polypeptide binding]; other site 657317002762 conserved gate region; other site 657317002763 putative PBP binding loops; other site 657317002764 ABC-ATPase subunit interface; other site 657317002765 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 657317002766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317002767 dimer interface [polypeptide binding]; other site 657317002768 conserved gate region; other site 657317002769 putative PBP binding loops; other site 657317002770 ABC-ATPase subunit interface; other site 657317002771 PBP superfamily domain; Region: PBP_like_2; cl17296 657317002772 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 657317002773 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317002774 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 657317002775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657317002776 NAD(P) binding site [chemical binding]; other site 657317002777 active site 657317002778 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 657317002779 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 657317002780 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 657317002781 active site 657317002782 catalytic site [active] 657317002783 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 657317002784 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 657317002785 putative active site [active] 657317002786 putative metal binding site [ion binding]; other site 657317002787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 657317002788 dimerization interface [polypeptide binding]; other site 657317002789 putative DNA binding site [nucleotide binding]; other site 657317002790 putative Zn2+ binding site [ion binding]; other site 657317002791 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 657317002792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657317002793 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657317002794 Heavy-metal-associated domain; Region: HMA; pfam00403 657317002795 metal-binding site [ion binding] 657317002796 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 657317002797 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 657317002798 HD domain; Region: HD_3; pfam13023 657317002799 RloB-like protein; Region: RloB; pfam13707 657317002800 AAA domain; Region: AAA_21; pfam13304 657317002801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317002802 ABC transporter signature motif; other site 657317002803 Walker B; other site 657317002804 D-loop; other site 657317002805 H-loop/switch region; other site 657317002806 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 657317002807 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 657317002808 substrate binding site [chemical binding]; other site 657317002809 active site 657317002810 catalytic residues [active] 657317002811 heterodimer interface [polypeptide binding]; other site 657317002812 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 657317002813 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 657317002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317002815 catalytic residue [active] 657317002816 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 657317002817 active site 657317002818 ribulose/triose binding site [chemical binding]; other site 657317002819 phosphate binding site [ion binding]; other site 657317002820 substrate (anthranilate) binding pocket [chemical binding]; other site 657317002821 product (indole) binding pocket [chemical binding]; other site 657317002822 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 657317002823 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 657317002824 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 657317002825 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 657317002826 Glutamine amidotransferase class-I; Region: GATase; pfam00117 657317002827 glutamine binding [chemical binding]; other site 657317002828 catalytic triad [active] 657317002829 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 657317002830 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 657317002831 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 657317002832 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657317002833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317002834 Coenzyme A binding pocket [chemical binding]; other site 657317002835 AAA ATPase domain; Region: AAA_16; pfam13191 657317002836 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 657317002837 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 657317002838 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657317002839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317002840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657317002841 Coenzyme A binding pocket [chemical binding]; other site 657317002842 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657317002843 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 657317002844 catalytic residues [active] 657317002845 Transposase; Region: DEDD_Tnp_IS110; pfam01548 657317002846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 657317002847 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 657317002848 proline aminopeptidase P II; Provisional; Region: PRK10879 657317002849 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 657317002850 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 657317002851 active site 657317002852 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 657317002853 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317002854 Helix-turn-helix domain; Region: HTH_17; pfam12728 657317002855 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 657317002856 23S rRNA interface [nucleotide binding]; other site 657317002857 L3 interface [polypeptide binding]; other site 657317002858 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 657317002859 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 657317002860 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 657317002861 dimerization interface 3.5A [polypeptide binding]; other site 657317002862 active site 657317002863 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 657317002864 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 657317002865 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657317002866 Walker A/P-loop; other site 657317002867 ATP binding site [chemical binding]; other site 657317002868 Q-loop/lid; other site 657317002869 ABC transporter signature motif; other site 657317002870 Walker B; other site 657317002871 D-loop; other site 657317002872 H-loop/switch region; other site 657317002873 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 657317002874 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657317002875 Walker A/P-loop; other site 657317002876 ATP binding site [chemical binding]; other site 657317002877 Q-loop/lid; other site 657317002878 ABC transporter signature motif; other site 657317002879 Walker B; other site 657317002880 D-loop; other site 657317002881 H-loop/switch region; other site 657317002882 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 657317002883 hypothetical protein; Validated; Region: PRK07682 657317002884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317002885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317002886 homodimer interface [polypeptide binding]; other site 657317002887 catalytic residue [active] 657317002888 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 657317002889 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 657317002890 AsnC family; Region: AsnC_trans_reg; pfam01037 657317002891 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 657317002892 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 657317002893 dimerization interface [polypeptide binding]; other site 657317002894 ATP binding site [chemical binding]; other site 657317002895 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 657317002896 VanW like protein; Region: VanW; pfam04294 657317002897 G5 domain; Region: G5; pfam07501 657317002898 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 657317002899 active site 657317002900 catalytic site [active] 657317002901 substrate binding site [chemical binding]; other site 657317002902 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 657317002903 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 657317002904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317002905 FeS/SAM binding site; other site 657317002906 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 657317002907 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317002908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317002909 salt bridge; other site 657317002910 non-specific DNA binding site [nucleotide binding]; other site 657317002911 sequence-specific DNA binding site [nucleotide binding]; other site 657317002912 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 657317002913 CAAX protease self-immunity; Region: Abi; pfam02517 657317002914 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 657317002915 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 657317002916 putative active site [active] 657317002917 nucleotide binding site [chemical binding]; other site 657317002918 nudix motif; other site 657317002919 putative metal binding site [ion binding]; other site 657317002920 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 657317002921 WYL domain; Region: WYL; pfam13280 657317002922 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 657317002923 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 657317002924 CRISPR-associated protein; Region: TIGR03986 657317002925 CRISPR-associated protein; Region: TIGR03986 657317002926 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 657317002927 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 657317002928 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 657317002929 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 657317002930 putative active site [active] 657317002931 putative NTP binding site [chemical binding]; other site 657317002932 putative nucleic acid binding site [nucleotide binding]; other site 657317002933 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 657317002934 NTP binding site [chemical binding]; other site 657317002935 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657317002936 flagellin; Validated; Region: PRK08026 657317002937 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657317002938 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 657317002939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 657317002940 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 657317002941 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 657317002942 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 657317002943 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657317002944 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 657317002945 nudix motif; other site 657317002946 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 657317002947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317002948 S-adenosylmethionine binding site [chemical binding]; other site 657317002949 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 657317002950 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657317002951 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 657317002952 EamA-like transporter family; Region: EamA; pfam00892 657317002953 EamA-like transporter family; Region: EamA; pfam00892 657317002954 Beta propeller domain; Region: Beta_propel; pfam09826 657317002955 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 657317002956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317002957 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317002958 DNA binding residues [nucleotide binding] 657317002959 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657317002960 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657317002961 active site 657317002962 ATP binding site [chemical binding]; other site 657317002963 substrate binding site [chemical binding]; other site 657317002964 activation loop (A-loop); other site 657317002965 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 657317002966 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 657317002967 dimer interface [polypeptide binding]; other site 657317002968 active site 657317002969 metal binding site [ion binding]; metal-binding site 657317002970 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 657317002971 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317002972 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317002973 Nitroreductase family; Region: Nitroreductase; pfam00881 657317002974 FMN binding site [chemical binding]; other site 657317002975 dimer interface [polypeptide binding]; other site 657317002976 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 657317002977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317002978 active site 657317002979 DNA binding site [nucleotide binding] 657317002980 Int/Topo IB signature motif; other site 657317002981 Recombinase; Region: Recombinase; pfam07508 657317002982 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 657317002983 Cellulose binding domain; Region: CBM_2; pfam00553 657317002984 Cellulose binding domain; Region: CBM_2; pfam00553 657317002985 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 657317002986 metal ion-dependent adhesion site (MIDAS); other site 657317002987 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 657317002988 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 657317002989 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 657317002990 putative RNA binding site [nucleotide binding]; other site 657317002991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317002992 S-adenosylmethionine binding site [chemical binding]; other site 657317002993 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 657317002994 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 657317002995 putative metal binding site; other site 657317002996 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 657317002997 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 657317002998 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 657317002999 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 657317003000 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 657317003001 DHHA1 domain; Region: DHHA1; pfam02272 657317003002 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657317003003 FtsX-like permease family; Region: FtsX; pfam02687 657317003004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317003005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317003006 Walker A/P-loop; other site 657317003007 ATP binding site [chemical binding]; other site 657317003008 Q-loop/lid; other site 657317003009 ABC transporter signature motif; other site 657317003010 Walker B; other site 657317003011 D-loop; other site 657317003012 H-loop/switch region; other site 657317003013 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 657317003014 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 657317003015 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 657317003016 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 657317003017 transmembrane helices; other site 657317003018 Transcriptional regulators [Transcription]; Region: GntR; COG1802 657317003019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317003020 DNA-binding site [nucleotide binding]; DNA binding site 657317003021 FCD domain; Region: FCD; pfam07729 657317003022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317003023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317003024 ATP binding site [chemical binding]; other site 657317003025 Mg2+ binding site [ion binding]; other site 657317003026 G-X-G motif; other site 657317003027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317003028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317003029 active site 657317003030 phosphorylation site [posttranslational modification] 657317003031 intermolecular recognition site; other site 657317003032 dimerization interface [polypeptide binding]; other site 657317003033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317003034 DNA binding site [nucleotide binding] 657317003035 trigger factor; Provisional; Region: tig; PRK01490 657317003036 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657317003037 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 657317003038 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 657317003039 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 657317003040 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657317003041 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317003042 Walker A/P-loop; other site 657317003043 ATP binding site [chemical binding]; other site 657317003044 Q-loop/lid; other site 657317003045 ABC transporter signature motif; other site 657317003046 Walker B; other site 657317003047 D-loop; other site 657317003048 H-loop/switch region; other site 657317003049 Predicted transcriptional regulators [Transcription]; Region: COG1725 657317003050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317003051 DNA-binding site [nucleotide binding]; DNA binding site 657317003052 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657317003053 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317003054 Walker A/P-loop; other site 657317003055 ATP binding site [chemical binding]; other site 657317003056 Q-loop/lid; other site 657317003057 ABC transporter signature motif; other site 657317003058 Walker B; other site 657317003059 D-loop; other site 657317003060 H-loop/switch region; other site 657317003061 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 657317003062 MgtE intracellular N domain; Region: MgtE_N; pfam03448 657317003063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 657317003064 Divalent cation transporter; Region: MgtE; pfam01769 657317003065 Sulfatase; Region: Sulfatase; pfam00884 657317003066 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 657317003067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 657317003068 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 657317003069 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 657317003070 toxin interface [polypeptide binding]; other site 657317003071 Zn binding site [ion binding]; other site 657317003072 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 657317003073 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 657317003074 AAA domain; Region: AAA_14; pfam13173 657317003075 Nuclease-related domain; Region: NERD; pfam08378 657317003076 ATP phosphoribosyltransferase; Region: HisG; cl15266 657317003077 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657317003078 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 657317003079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317003080 ATP binding site [chemical binding]; other site 657317003081 Mg2+ binding site [ion binding]; other site 657317003082 G-X-G motif; other site 657317003083 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317003084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317003085 active site 657317003086 phosphorylation site [posttranslational modification] 657317003087 intermolecular recognition site; other site 657317003088 dimerization interface [polypeptide binding]; other site 657317003089 LytTr DNA-binding domain; Region: LytTR; smart00850 657317003090 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 657317003091 Cation efflux family; Region: Cation_efflux; pfam01545 657317003092 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657317003093 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657317003094 Catalytic site [active] 657317003095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 657317003096 ATP binding site [chemical binding]; other site 657317003097 Mg2+ binding site [ion binding]; other site 657317003098 G-X-G motif; other site 657317003099 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 657317003100 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317003101 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 657317003102 Chain length determinant protein; Region: Wzz; cl15801 657317003103 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 657317003104 homopentamer interface [polypeptide binding]; other site 657317003105 active site 657317003106 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 657317003107 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 657317003108 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 657317003109 dimerization interface [polypeptide binding]; other site 657317003110 active site 657317003111 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 657317003112 Lumazine binding domain; Region: Lum_binding; pfam00677 657317003113 Lumazine binding domain; Region: Lum_binding; pfam00677 657317003114 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 657317003115 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 657317003116 catalytic motif [active] 657317003117 Zn binding site [ion binding]; other site 657317003118 RibD C-terminal domain; Region: RibD_C; cl17279 657317003119 Putative zinc-finger; Region: zf-HC2; pfam13490 657317003120 glutamate dehydrogenase; Provisional; Region: PRK09414 657317003121 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 657317003122 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 657317003123 NAD(P) binding site [chemical binding]; other site 657317003124 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 657317003125 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 657317003126 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 657317003127 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 657317003128 dimer interface [polypeptide binding]; other site 657317003129 active site 657317003130 CoA binding pocket [chemical binding]; other site 657317003131 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 657317003132 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 657317003133 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 657317003134 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 657317003135 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 657317003136 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 657317003137 dimer interface [polypeptide binding]; other site 657317003138 active site 657317003139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 657317003140 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 657317003141 NAD(P) binding site [chemical binding]; other site 657317003142 homotetramer interface [polypeptide binding]; other site 657317003143 homodimer interface [polypeptide binding]; other site 657317003144 active site 657317003145 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 657317003146 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 657317003147 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 657317003148 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 657317003149 FMN binding site [chemical binding]; other site 657317003150 substrate binding site [chemical binding]; other site 657317003151 putative catalytic residue [active] 657317003152 acyl carrier protein; Provisional; Region: acpP; PRK00982 657317003153 AAA domain; Region: AAA_14; pfam13173 657317003154 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 657317003155 Transglycosylase; Region: Transgly; pfam00912 657317003156 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 657317003157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 657317003158 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 657317003159 Ligand binding site; other site 657317003160 metal-binding site 657317003161 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 657317003162 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 657317003163 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 657317003164 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 657317003165 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 657317003166 catalytic loop [active] 657317003167 iron binding site [ion binding]; other site 657317003168 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 657317003169 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 657317003170 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 657317003171 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 657317003172 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 657317003173 CPxP motif; other site 657317003174 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 657317003175 selenophosphate synthetase; Provisional; Region: PRK00943 657317003176 dimerization interface [polypeptide binding]; other site 657317003177 putative ATP binding site [chemical binding]; other site 657317003178 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 657317003179 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 657317003180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317003181 catalytic residue [active] 657317003182 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 657317003183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317003184 Walker A/P-loop; other site 657317003185 ATP binding site [chemical binding]; other site 657317003186 Q-loop/lid; other site 657317003187 ABC transporter signature motif; other site 657317003188 Walker B; other site 657317003189 D-loop; other site 657317003190 H-loop/switch region; other site 657317003191 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 657317003192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317003193 dimer interface [polypeptide binding]; other site 657317003194 conserved gate region; other site 657317003195 putative PBP binding loops; other site 657317003196 ABC-ATPase subunit interface; other site 657317003197 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 657317003198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657317003199 MOSC domain; Region: MOSC; pfam03473 657317003200 XdhC Rossmann domain; Region: XdhC_C; pfam13478 657317003201 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 657317003202 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 657317003203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317003204 FeS/SAM binding site; other site 657317003205 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 657317003206 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 657317003207 putative MPT binding site; other site 657317003208 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 657317003209 MPT binding site; other site 657317003210 trimer interface [polypeptide binding]; other site 657317003211 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 657317003212 trimer interface [polypeptide binding]; other site 657317003213 dimer interface [polypeptide binding]; other site 657317003214 putative active site [active] 657317003215 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 657317003216 HlyD family secretion protein; Region: HlyD_3; pfam13437 657317003217 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 657317003218 xanthine permease; Region: pbuX; TIGR03173 657317003219 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657317003220 catalytic core [active] 657317003221 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 657317003222 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 657317003223 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 657317003224 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 657317003225 domain interfaces; other site 657317003226 active site 657317003227 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 657317003228 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 657317003229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657317003230 Protein of unknown function (DUF464); Region: DUF464; cl01080 657317003231 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657317003232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317003233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317003234 DNA binding residues [nucleotide binding] 657317003235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657317003236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 657317003237 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657317003238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317003239 Zn2+ binding site [ion binding]; other site 657317003240 Mg2+ binding site [ion binding]; other site 657317003241 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 657317003242 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 657317003243 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 657317003244 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 657317003245 nudix motif; other site 657317003246 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 657317003247 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 657317003248 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 657317003249 Predicted membrane protein [Function unknown]; Region: COG1971 657317003250 Domain of unknown function DUF; Region: DUF204; pfam02659 657317003251 Domain of unknown function DUF; Region: DUF204; pfam02659 657317003252 Predicted transcriptional regulators [Transcription]; Region: COG1695 657317003253 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 657317003254 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 657317003255 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 657317003256 Flagellar protein FliS; Region: FliS; cl00654 657317003257 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 657317003258 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 657317003259 FlaG protein; Region: FlaG; pfam03646 657317003260 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 657317003261 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 657317003262 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 657317003263 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 657317003264 DHH family; Region: DHH; pfam01368 657317003265 DHHA1 domain; Region: DHHA1; pfam02272 657317003266 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 657317003267 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 657317003268 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 657317003269 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 657317003270 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 657317003271 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657317003272 dimer interface [polypeptide binding]; other site 657317003273 ssDNA binding site [nucleotide binding]; other site 657317003274 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657317003275 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 657317003276 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 657317003277 NAD-dependent deacetylase; Provisional; Region: PRK00481 657317003278 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 657317003279 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 657317003280 TrkA-N domain; Region: TrkA_N; pfam02254 657317003281 TrkA-C domain; Region: TrkA_C; pfam02080 657317003282 Predicted methyltransferases [General function prediction only]; Region: COG0313 657317003283 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 657317003284 putative SAM binding site [chemical binding]; other site 657317003285 putative homodimer interface [polypeptide binding]; other site 657317003286 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 657317003287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317003288 S-adenosylmethionine binding site [chemical binding]; other site 657317003289 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 657317003290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317003291 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 657317003292 Walker A motif; other site 657317003293 ATP binding site [chemical binding]; other site 657317003294 Walker B motif; other site 657317003295 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 657317003296 Protein of unknown function (DUF327); Region: DUF327; pfam03885 657317003297 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 657317003298 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657317003299 active site 657317003300 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657317003301 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 657317003302 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317003303 catalytic residue [active] 657317003304 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 657317003305 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 657317003306 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 657317003307 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 657317003308 active site 657317003309 nucleophile elbow; other site 657317003310 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 657317003311 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657317003312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317003313 S-adenosylmethionine binding site [chemical binding]; other site 657317003314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657317003315 TPR motif; other site 657317003316 Tetratricopeptide repeat; Region: TPR_12; pfam13424 657317003317 binding surface 657317003318 peptidase T; Region: peptidase-T; TIGR01882 657317003319 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 657317003320 metal binding site [ion binding]; metal-binding site 657317003321 dimer interface [polypeptide binding]; other site 657317003322 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 657317003323 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 657317003324 ATP binding site [chemical binding]; other site 657317003325 Mg++ binding site [ion binding]; other site 657317003326 motif III; other site 657317003327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317003328 nucleotide binding region [chemical binding]; other site 657317003329 ATP-binding site [chemical binding]; other site 657317003330 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 657317003331 RNA binding site [nucleotide binding]; other site 657317003332 BioY family; Region: BioY; pfam02632 657317003333 Maf-like protein; Region: Maf; pfam02545 657317003334 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 657317003335 active site 657317003336 dimer interface [polypeptide binding]; other site 657317003337 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 657317003338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317003339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317003340 dimerization interface [polypeptide binding]; other site 657317003341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317003342 dimer interface [polypeptide binding]; other site 657317003343 phosphorylation site [posttranslational modification] 657317003344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317003345 ATP binding site [chemical binding]; other site 657317003346 Mg2+ binding site [ion binding]; other site 657317003347 G-X-G motif; other site 657317003348 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 657317003349 PLD-like domain; Region: PLDc_2; pfam13091 657317003350 putative active site [active] 657317003351 catalytic site [active] 657317003352 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 657317003353 PLD-like domain; Region: PLDc_2; pfam13091 657317003354 putative active site [active] 657317003355 catalytic site [active] 657317003356 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 657317003357 homodimer interface [polypeptide binding]; other site 657317003358 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 657317003359 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 657317003360 active site 657317003361 homodimer interface [polypeptide binding]; other site 657317003362 catalytic site [active] 657317003363 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 657317003364 Penicillinase repressor; Region: Pencillinase_R; pfam03965 657317003365 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 657317003366 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 657317003367 active site 657317003368 Bacterial SH3 domain homologues; Region: SH3b; smart00287 657317003369 Bacterial SH3 domain; Region: SH3_3; pfam08239 657317003370 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 657317003371 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 657317003372 hybrid cluster protein; Provisional; Region: PRK05290 657317003373 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657317003374 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657317003375 ACS interaction site; other site 657317003376 CODH interaction site; other site 657317003377 metal cluster binding site [ion binding]; other site 657317003378 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 657317003379 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657317003380 flagellin; Validated; Region: PRK06819 657317003381 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657317003382 Global regulator protein family; Region: CsrA; pfam02599 657317003383 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317003384 active site 657317003385 DNA binding site [nucleotide binding] 657317003386 Int/Topo IB signature motif; other site 657317003387 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 657317003388 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 657317003389 putative active site; other site 657317003390 catalytic triad [active] 657317003391 putative dimer interface [polypeptide binding]; other site 657317003392 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 657317003393 agmatine deiminase; Region: agmatine_aguA; TIGR03380 657317003394 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 657317003395 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 657317003396 dimer interface [polypeptide binding]; other site 657317003397 active site 657317003398 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657317003399 catalytic residues [active] 657317003400 substrate binding site [chemical binding]; other site 657317003401 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 657317003402 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 657317003403 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 657317003404 spermidine synthase; Provisional; Region: PRK00811 657317003405 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 657317003406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 657317003407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317003408 catalytic residue [active] 657317003409 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 657317003410 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 657317003411 flagellin; Validated; Region: PRK08026 657317003412 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 657317003413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317003414 active site 657317003415 DNA binding site [nucleotide binding] 657317003416 Int/Topo IB signature motif; other site 657317003417 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317003418 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657317003419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 657317003420 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 657317003421 CAAX protease self-immunity; Region: Abi; pfam02517 657317003422 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 657317003423 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317003424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317003425 non-specific DNA binding site [nucleotide binding]; other site 657317003426 salt bridge; other site 657317003427 sequence-specific DNA binding site [nucleotide binding]; other site 657317003428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317003429 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317003430 Int/Topo IB signature motif; other site 657317003431 Predicted ATPase [General function prediction only]; Region: COG3910 657317003432 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 657317003433 Walker A/P-loop; other site 657317003434 ATP binding site [chemical binding]; other site 657317003435 Q-loop/lid; other site 657317003436 ABC transporter signature motif; other site 657317003437 Walker B; other site 657317003438 D-loop; other site 657317003439 H-loop/switch region; other site 657317003440 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 657317003441 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 657317003442 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 657317003443 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 657317003444 FMN binding site [chemical binding]; other site 657317003445 Sugar fermentation stimulation protein; Region: SfsA; cl00647 657317003446 Sugar fermentation stimulation protein; Region: SfsA; cl00647 657317003447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657317003448 maltose O-acetyltransferase; Provisional; Region: PRK10092 657317003449 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 657317003450 active site 657317003451 substrate binding site [chemical binding]; other site 657317003452 trimer interface [polypeptide binding]; other site 657317003453 CoA binding site [chemical binding]; other site 657317003454 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 657317003455 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 657317003456 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657317003457 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317003458 dimer interface [polypeptide binding]; other site 657317003459 putative CheW interface [polypeptide binding]; other site 657317003460 AAA domain; Region: AAA_14; pfam13173 657317003461 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 657317003462 flavodoxin; Provisional; Region: PRK06242 657317003463 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657317003464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317003465 motif II; other site 657317003466 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 657317003467 active site 657317003468 metal binding site [ion binding]; metal-binding site 657317003469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657317003470 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 657317003471 active site 657317003472 catalytic residues [active] 657317003473 metal binding site [ion binding]; metal-binding site 657317003474 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 657317003475 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 657317003476 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 657317003477 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 657317003478 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 657317003479 active site 657317003480 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 657317003481 DDE superfamily endonuclease; Region: DDE_5; cl17874 657317003482 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 657317003483 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657317003484 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317003485 dimerization interface [polypeptide binding]; other site 657317003486 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317003487 dimer interface [polypeptide binding]; other site 657317003488 putative CheW interface [polypeptide binding]; other site 657317003489 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 657317003490 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 657317003491 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 657317003492 putative ADP-ribose binding site [chemical binding]; other site 657317003493 putative active site [active] 657317003494 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 657317003495 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657317003496 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 657317003497 PLD-like domain; Region: PLDc_2; pfam13091 657317003498 putative homodimer interface [polypeptide binding]; other site 657317003499 putative active site [active] 657317003500 catalytic site [active] 657317003501 DEAD-like helicases superfamily; Region: DEXDc; smart00487 657317003502 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317003503 ATP binding site [chemical binding]; other site 657317003504 putative Mg++ binding site [ion binding]; other site 657317003505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317003506 nucleotide binding region [chemical binding]; other site 657317003507 ATP-binding site [chemical binding]; other site 657317003508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 657317003509 Methyltransferase domain; Region: Methyltransf_23; pfam13489 657317003510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317003511 S-adenosylmethionine binding site [chemical binding]; other site 657317003512 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 657317003513 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 657317003514 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 657317003515 ADP-ribose binding site [chemical binding]; other site 657317003516 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 657317003517 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 657317003518 SmpB-tmRNA interface; other site 657317003519 ribonuclease R; Region: RNase_R; TIGR02063 657317003520 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 657317003521 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 657317003522 RNB domain; Region: RNB; pfam00773 657317003523 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 657317003524 RNA binding site [nucleotide binding]; other site 657317003525 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 657317003526 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 657317003527 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657317003528 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 657317003529 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 657317003530 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 657317003531 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 657317003532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317003533 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317003534 Walker A motif; other site 657317003535 Walker A/P-loop; other site 657317003536 ATP binding site [chemical binding]; other site 657317003537 ATP binding site [chemical binding]; other site 657317003538 Walker B motif; other site 657317003539 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 657317003540 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 657317003541 tetramer interface [polypeptide binding]; other site 657317003542 active site 657317003543 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 657317003544 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 657317003545 ATP binding site [chemical binding]; other site 657317003546 active site 657317003547 substrate binding site [chemical binding]; other site 657317003548 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 657317003549 phosphoglyceromutase; Provisional; Region: PRK05434 657317003550 triosephosphate isomerase; Provisional; Region: PRK14567 657317003551 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 657317003552 substrate binding site [chemical binding]; other site 657317003553 dimer interface [polypeptide binding]; other site 657317003554 catalytic triad [active] 657317003555 Phosphoglycerate kinase; Region: PGK; pfam00162 657317003556 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 657317003557 substrate binding site [chemical binding]; other site 657317003558 hinge regions; other site 657317003559 ADP binding site [chemical binding]; other site 657317003560 catalytic site [active] 657317003561 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 657317003562 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 657317003563 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 657317003564 histidinol-phosphatase; Provisional; Region: PRK05588 657317003565 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657317003566 active site 657317003567 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 657317003568 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 657317003569 active site 657317003570 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 657317003571 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 657317003572 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 657317003573 dimerization interface [polypeptide binding]; other site 657317003574 ATP binding site [chemical binding]; other site 657317003575 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 657317003576 dimerization interface [polypeptide binding]; other site 657317003577 ATP binding site [chemical binding]; other site 657317003578 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 657317003579 putative active site [active] 657317003580 catalytic triad [active] 657317003581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317003582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317003583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657317003584 dimerization interface [polypeptide binding]; other site 657317003585 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 657317003586 DEAD_2; Region: DEAD_2; pfam06733 657317003587 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 657317003588 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 657317003589 regulatory protein interface [polypeptide binding]; other site 657317003590 regulatory phosphorylation site [posttranslational modification]; other site 657317003591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317003592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317003593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657317003594 dimerization interface [polypeptide binding]; other site 657317003595 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 657317003596 RNA/DNA hybrid binding site [nucleotide binding]; other site 657317003597 active site 657317003598 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 657317003599 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 657317003600 GTP/Mg2+ binding site [chemical binding]; other site 657317003601 G4 box; other site 657317003602 G5 box; other site 657317003603 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 657317003604 G1 box; other site 657317003605 G1 box; other site 657317003606 GTP/Mg2+ binding site [chemical binding]; other site 657317003607 Switch I region; other site 657317003608 G2 box; other site 657317003609 G2 box; other site 657317003610 G3 box; other site 657317003611 G3 box; other site 657317003612 Switch II region; other site 657317003613 Switch II region; other site 657317003614 G4 box; other site 657317003615 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657317003616 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657317003617 Catalytic site [active] 657317003618 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 657317003619 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 657317003620 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 657317003621 RimM N-terminal domain; Region: RimM; pfam01782 657317003622 PRC-barrel domain; Region: PRC; pfam05239 657317003623 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 657317003624 hypothetical protein; Provisional; Region: PRK00468 657317003625 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 657317003626 signal recognition particle protein; Provisional; Region: PRK10867 657317003627 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 657317003628 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 657317003629 P loop; other site 657317003630 GTP binding site [chemical binding]; other site 657317003631 Signal peptide binding domain; Region: SRP_SPB; pfam02978 657317003632 putative DNA-binding protein; Validated; Region: PRK00118 657317003633 threonine dehydratase; Provisional; Region: PRK08198 657317003634 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 657317003635 tetramer interface [polypeptide binding]; other site 657317003636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317003637 catalytic residue [active] 657317003638 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 657317003639 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 657317003640 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 657317003641 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317003642 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 657317003643 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 657317003644 Walker A/P-loop; other site 657317003645 ATP binding site [chemical binding]; other site 657317003646 Q-loop/lid; other site 657317003647 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 657317003648 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 657317003649 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 657317003650 ABC transporter signature motif; other site 657317003651 Walker B; other site 657317003652 D-loop; other site 657317003653 H-loop/switch region; other site 657317003654 ribonuclease III; Reviewed; Region: rnc; PRK00102 657317003655 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 657317003656 dimerization interface [polypeptide binding]; other site 657317003657 active site 657317003658 metal binding site [ion binding]; metal-binding site 657317003659 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 657317003660 dsRNA binding site [nucleotide binding]; other site 657317003661 acyl carrier protein; Provisional; Region: acpP; PRK00982 657317003662 putative phosphate acyltransferase; Provisional; Region: PRK05331 657317003663 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 657317003664 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 657317003665 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 657317003666 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 657317003667 propionate/acetate kinase; Provisional; Region: PRK12379 657317003668 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 657317003669 hypothetical protein; Provisional; Region: PRK13670 657317003670 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 657317003671 active site 657317003672 dimer interface [polypeptide binding]; other site 657317003673 metal binding site [ion binding]; metal-binding site 657317003674 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 657317003675 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 657317003676 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 657317003677 RNA/DNA hybrid binding site [nucleotide binding]; other site 657317003678 active site 657317003679 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657317003680 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657317003681 Walker A/P-loop; other site 657317003682 ATP binding site [chemical binding]; other site 657317003683 Q-loop/lid; other site 657317003684 ABC transporter signature motif; other site 657317003685 Walker B; other site 657317003686 D-loop; other site 657317003687 H-loop/switch region; other site 657317003688 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657317003689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657317003690 membrane-bound complex binding site; other site 657317003691 hinge residues; other site 657317003692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657317003693 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657317003694 substrate binding pocket [chemical binding]; other site 657317003695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657317003696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317003697 dimer interface [polypeptide binding]; other site 657317003698 conserved gate region; other site 657317003699 putative PBP binding loops; other site 657317003700 ABC-ATPase subunit interface; other site 657317003701 peptide chain release factor 1; Validated; Region: prfA; PRK00591 657317003702 This domain is found in peptide chain release factors; Region: PCRF; smart00937 657317003703 RF-1 domain; Region: RF-1; pfam00472 657317003704 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 657317003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317003706 S-adenosylmethionine binding site [chemical binding]; other site 657317003707 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 657317003708 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 657317003709 transcription termination factor Rho; Provisional; Region: rho; PRK09376 657317003710 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 657317003711 RNA binding site [nucleotide binding]; other site 657317003712 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317003713 Walker A motif; other site 657317003714 ATP binding site [chemical binding]; other site 657317003715 Walker B motif; other site 657317003716 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 657317003717 Malic enzyme, N-terminal domain; Region: malic; pfam00390 657317003718 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 657317003719 putative NAD(P) binding site [chemical binding]; other site 657317003720 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 657317003721 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317003722 FeS/SAM binding site; other site 657317003723 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 657317003724 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 657317003725 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 657317003726 dihydrodipicolinate synthase; Region: dapA; TIGR00674 657317003727 dimer interface [polypeptide binding]; other site 657317003728 active site 657317003729 catalytic residue [active] 657317003730 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 657317003731 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657317003732 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657317003733 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657317003734 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 657317003735 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 657317003736 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 657317003737 Cupin domain; Region: Cupin_2; cl17218 657317003738 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 657317003739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317003740 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317003741 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 657317003742 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 657317003743 DRTGG domain; Region: DRTGG; pfam07085 657317003744 DHHA2 domain; Region: DHHA2; pfam02833 657317003745 phosphodiesterase; Provisional; Region: PRK12704 657317003746 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 657317003747 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 657317003748 dimer interface [polypeptide binding]; other site 657317003749 PYR/PP interface [polypeptide binding]; other site 657317003750 TPP binding site [chemical binding]; other site 657317003751 substrate binding site [chemical binding]; other site 657317003752 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657317003753 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 657317003754 Domain of unknown function; Region: EKR; pfam10371 657317003755 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657317003756 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 657317003757 TPP-binding site [chemical binding]; other site 657317003758 dimer interface [polypeptide binding]; other site 657317003759 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 657317003760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317003761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317003762 ABC transporter; Region: ABC_tran_2; pfam12848 657317003763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317003764 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 657317003765 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 657317003766 ligand binding site [chemical binding]; other site 657317003767 active site 657317003768 UGI interface [polypeptide binding]; other site 657317003769 catalytic site [active] 657317003770 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 657317003771 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 657317003772 substrate binding site [chemical binding]; other site 657317003773 glutamase interaction surface [polypeptide binding]; other site 657317003774 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 657317003775 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 657317003776 putative active site [active] 657317003777 oxyanion strand; other site 657317003778 catalytic triad [active] 657317003779 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 657317003780 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 657317003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317003782 active site 657317003783 phosphorylation site [posttranslational modification] 657317003784 intermolecular recognition site; other site 657317003785 dimerization interface [polypeptide binding]; other site 657317003786 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 657317003787 HAMP domain; Region: HAMP; pfam00672 657317003788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317003789 dimer interface [polypeptide binding]; other site 657317003790 phosphorylation site [posttranslational modification] 657317003791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317003792 ATP binding site [chemical binding]; other site 657317003793 Mg2+ binding site [ion binding]; other site 657317003794 G-X-G motif; other site 657317003795 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 657317003796 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657317003797 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317003798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317003799 non-specific DNA binding site [nucleotide binding]; other site 657317003800 salt bridge; other site 657317003801 sequence-specific DNA binding site [nucleotide binding]; other site 657317003802 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 657317003803 Catalytic site [active] 657317003804 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 657317003805 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 657317003806 active site 657317003807 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657317003808 substrate binding site [chemical binding]; other site 657317003809 catalytic residues [active] 657317003810 dimer interface [polypeptide binding]; other site 657317003811 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 657317003812 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 657317003813 N-acetyl-D-glucosamine binding site [chemical binding]; other site 657317003814 catalytic residue [active] 657317003815 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 657317003816 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657317003817 active site 657317003818 metal binding site [ion binding]; metal-binding site 657317003819 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 657317003820 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 657317003821 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657317003822 CheC-like family; Region: CheC; pfam04509 657317003823 Chemotaxis phosphatase CheX; Region: CheX; cl15816 657317003824 Response regulator receiver domain; Region: Response_reg; pfam00072 657317003825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317003826 active site 657317003827 phosphorylation site [posttranslational modification] 657317003828 intermolecular recognition site; other site 657317003829 dimerization interface [polypeptide binding]; other site 657317003830 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 657317003831 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 657317003832 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 657317003833 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657317003834 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 657317003835 active site 657317003836 metal binding site [ion binding]; metal-binding site 657317003837 dimerization interface [polypeptide binding]; other site 657317003838 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 657317003839 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657317003840 active site 657317003841 HIGH motif; other site 657317003842 nucleotide binding site [chemical binding]; other site 657317003843 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 657317003844 KMSKS motif; other site 657317003845 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 657317003846 tRNA binding surface [nucleotide binding]; other site 657317003847 anticodon binding site; other site 657317003848 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 657317003849 homotrimer interaction site [polypeptide binding]; other site 657317003850 zinc binding site [ion binding]; other site 657317003851 CDP-binding sites; other site 657317003852 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 657317003853 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657317003854 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657317003855 homodimer interface [polypeptide binding]; other site 657317003856 substrate-cofactor binding pocket; other site 657317003857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317003858 catalytic residue [active] 657317003859 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 657317003860 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 657317003861 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657317003862 active site 657317003863 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 657317003864 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 657317003865 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 657317003866 substrate binding pocket [chemical binding]; other site 657317003867 dimer interface [polypeptide binding]; other site 657317003868 inhibitor binding site; inhibition site 657317003869 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 657317003870 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 657317003871 B12 binding site [chemical binding]; other site 657317003872 cobalt ligand [ion binding]; other site 657317003873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317003874 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657317003875 active site 657317003876 motif I; other site 657317003877 motif II; other site 657317003878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317003879 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317003880 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657317003881 elongation factor P; Validated; Region: PRK00529 657317003882 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 657317003883 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 657317003884 RNA binding site [nucleotide binding]; other site 657317003885 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 657317003886 RNA binding site [nucleotide binding]; other site 657317003887 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 657317003888 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 657317003889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317003890 active site 657317003891 motif I; other site 657317003892 motif II; other site 657317003893 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 657317003894 ATP cone domain; Region: ATP-cone; pfam03477 657317003895 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 657317003896 GTP-binding protein YchF; Reviewed; Region: PRK09601 657317003897 YchF GTPase; Region: YchF; cd01900 657317003898 G1 box; other site 657317003899 GTP/Mg2+ binding site [chemical binding]; other site 657317003900 Switch I region; other site 657317003901 G2 box; other site 657317003902 Switch II region; other site 657317003903 G3 box; other site 657317003904 G4 box; other site 657317003905 G5 box; other site 657317003906 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 657317003907 transcriptional antiterminator BglG; Provisional; Region: PRK09772 657317003908 PRD domain; Region: PRD; pfam00874 657317003909 PRD domain; Region: PRD; pfam00874 657317003910 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 657317003911 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 657317003912 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 657317003913 active site turn [active] 657317003914 phosphorylation site [posttranslational modification] 657317003915 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 657317003916 HPr interaction site; other site 657317003917 glycerol kinase (GK) interaction site [polypeptide binding]; other site 657317003918 active site 657317003919 phosphorylation site [posttranslational modification] 657317003920 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 657317003921 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 657317003922 MoxR-like ATPases [General function prediction only]; Region: COG0714 657317003923 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317003924 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317003925 catalytic residues [active] 657317003926 catalytic nucleophile [active] 657317003927 Recombinase; Region: Recombinase; pfam07508 657317003928 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317003929 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317003930 catalytic residues [active] 657317003931 catalytic nucleophile [active] 657317003932 Recombinase; Region: Recombinase; pfam07508 657317003933 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317003934 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317003935 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317003936 catalytic residues [active] 657317003937 catalytic nucleophile [active] 657317003938 Recombinase; Region: Recombinase; pfam07508 657317003939 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317003940 PemK-like protein; Region: PemK; pfam02452 657317003941 TFIIF-interacting CTD phosphatases, including NLI-interacting factor [Transcription]; Region: FCP1; COG5190 657317003942 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 657317003943 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 657317003944 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657317003945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317003946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317003947 DNA binding residues [nucleotide binding] 657317003948 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 657317003949 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 657317003950 Transposase; Region: DEDD_Tnp_IS110; pfam01548 657317003951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 657317003952 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 657317003953 SpoVG; Region: SpoVG; cl00915 657317003954 SpoVG; Region: SpoVG; pfam04026 657317003955 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 657317003956 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 657317003957 AAA-like domain; Region: AAA_10; pfam12846 657317003958 Domain of unknown function DUF87; Region: DUF87; pfam01935 657317003959 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 657317003960 AAA-like domain; Region: AAA_10; pfam12846 657317003961 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317003962 Walker A motif; other site 657317003963 ATP binding site [chemical binding]; other site 657317003964 Walker B motif; other site 657317003965 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 657317003966 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 657317003967 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 657317003968 Toprim-like; Region: Toprim_2; pfam13155 657317003969 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 657317003970 Mg binding site [ion binding]; other site 657317003971 nucleotide binding site [chemical binding]; other site 657317003972 putative protofilament interface [polypeptide binding]; other site 657317003973 MoxR-like ATPases [General function prediction only]; Region: COG0714 657317003974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317003975 Walker A motif; other site 657317003976 ATP binding site [chemical binding]; other site 657317003977 Walker B motif; other site 657317003978 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 657317003979 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 657317003980 Na2 binding site [ion binding]; other site 657317003981 putative substrate binding site 1 [chemical binding]; other site 657317003982 Na binding site 1 [ion binding]; other site 657317003983 putative substrate binding site 2 [chemical binding]; other site 657317003984 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 657317003985 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 657317003986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317003987 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657317003988 active site 657317003989 motif I; other site 657317003990 motif II; other site 657317003991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317003992 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 657317003993 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 657317003994 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 657317003995 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657317003996 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657317003997 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657317003998 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657317003999 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 657317004000 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 657317004001 putative substrate binding site [chemical binding]; other site 657317004002 putative ATP binding site [chemical binding]; other site 657317004003 MFS/sugar transport protein; Region: MFS_2; pfam13347 657317004004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657317004005 putative substrate translocation pore; other site 657317004006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 657317004007 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 657317004008 active site 657317004009 metal binding site [ion binding]; metal-binding site 657317004010 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 657317004011 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 657317004012 putative NAD(P) binding site [chemical binding]; other site 657317004013 catalytic Zn binding site [ion binding]; other site 657317004014 structural Zn binding site [ion binding]; other site 657317004015 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 657317004016 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657317004017 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 657317004018 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 657317004019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 657317004020 nucleotide binding site [chemical binding]; other site 657317004021 Mrr N-terminal domain; Region: Mrr_N; pfam14338 657317004022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317004023 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 657317004024 Walker A motif; other site 657317004025 ATP binding site [chemical binding]; other site 657317004026 Walker B motif; other site 657317004027 arginine finger; other site 657317004028 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 657317004029 KilA-N domain; Region: KilA-N; pfam04383 657317004030 Recombinase; Region: Recombinase; pfam07508 657317004031 ORF6N domain; Region: ORF6N; pfam10543 657317004032 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 657317004033 DNA-binding interface [nucleotide binding]; DNA binding site 657317004034 Maff2 family; Region: Maff2; pfam12750 657317004035 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 657317004036 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 657317004037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317004038 motif II; other site 657317004039 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657317004040 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 657317004041 putative active site [active] 657317004042 putative metal binding site [ion binding]; other site 657317004043 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657317004044 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317004045 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 657317004046 catalytic residues [active] 657317004047 catalytic nucleophile [active] 657317004048 Recombinase; Region: Recombinase; pfam07508 657317004049 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317004050 AAA domain; Region: AAA_22; pfam13401 657317004051 Abi-like protein; Region: Abi_2; pfam07751 657317004052 Mrr N-terminal domain; Region: Mrr_N; pfam14338 657317004053 Restriction endonuclease; Region: Mrr_cat; pfam04471 657317004054 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317004055 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 657317004056 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317004057 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 657317004058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317004059 active site 657317004060 DNA binding site [nucleotide binding] 657317004061 Int/Topo IB signature motif; other site 657317004062 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 657317004063 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 657317004064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317004065 S-adenosylmethionine binding site [chemical binding]; other site 657317004066 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 657317004067 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 657317004068 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 657317004069 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317004070 ATP binding site [chemical binding]; other site 657317004071 putative Mg++ binding site [ion binding]; other site 657317004072 Helix-turn-helix domain; Region: HTH_17; cl17695 657317004073 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 657317004074 ParB-like nuclease domain; Region: ParB; smart00470 657317004075 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 657317004076 TRAM domain; Region: TRAM; cl01282 657317004077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317004078 S-adenosylmethionine binding site [chemical binding]; other site 657317004079 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 657317004080 Part of AAA domain; Region: AAA_19; pfam13245 657317004081 Family description; Region: UvrD_C_2; pfam13538 657317004082 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 657317004083 Trp repressor protein; Region: Trp_repressor; cl17266 657317004084 CAAX protease self-immunity; Region: Abi; pfam02517 657317004085 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 657317004086 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 657317004087 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317004089 homodimer interface [polypeptide binding]; other site 657317004090 catalytic residue [active] 657317004091 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317004092 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657317004093 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 657317004094 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 657317004095 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 657317004096 galactokinase; Provisional; Region: PRK05322 657317004097 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 657317004098 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657317004099 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 657317004100 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 657317004101 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 657317004102 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657317004103 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657317004104 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657317004105 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 657317004106 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317004107 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317004108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317004109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317004110 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 657317004111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317004112 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657317004113 active site 657317004114 motif I; other site 657317004115 motif II; other site 657317004116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317004117 motif II; other site 657317004118 DNA helicase II; Region: uvrD; TIGR01075 657317004119 Predicted transcriptional regulators [Transcription]; Region: COG1695 657317004120 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 657317004121 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 657317004122 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 657317004123 active site 657317004124 catalytic residues [active] 657317004125 FeoA domain; Region: FeoA; pfam04023 657317004126 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 657317004127 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 657317004128 G1 box; other site 657317004129 GTP/Mg2+ binding site [chemical binding]; other site 657317004130 Switch I region; other site 657317004131 G2 box; other site 657317004132 G3 box; other site 657317004133 Switch II region; other site 657317004134 G4 box; other site 657317004135 G5 box; other site 657317004136 Nucleoside recognition; Region: Gate; pfam07670 657317004137 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 657317004138 Nucleoside recognition; Region: Gate; pfam07670 657317004139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317004140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317004141 dimer interface [polypeptide binding]; other site 657317004142 phosphorylation site [posttranslational modification] 657317004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317004144 ATP binding site [chemical binding]; other site 657317004145 Mg2+ binding site [ion binding]; other site 657317004146 G-X-G motif; other site 657317004147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317004148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317004149 active site 657317004150 phosphorylation site [posttranslational modification] 657317004151 intermolecular recognition site; other site 657317004152 dimerization interface [polypeptide binding]; other site 657317004153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317004154 DNA binding site [nucleotide binding] 657317004155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657317004156 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657317004157 FtsX-like permease family; Region: FtsX; pfam02687 657317004158 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 657317004159 FtsX-like permease family; Region: FtsX; pfam02687 657317004160 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317004161 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317004162 Walker A/P-loop; other site 657317004163 ATP binding site [chemical binding]; other site 657317004164 Q-loop/lid; other site 657317004165 ABC transporter signature motif; other site 657317004166 Walker B; other site 657317004167 D-loop; other site 657317004168 H-loop/switch region; other site 657317004169 aminotransferase AlaT; Validated; Region: PRK09265 657317004170 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317004171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317004172 homodimer interface [polypeptide binding]; other site 657317004173 catalytic residue [active] 657317004174 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 657317004175 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 657317004176 putative ATP binding site [chemical binding]; other site 657317004177 putative substrate interface [chemical binding]; other site 657317004178 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 657317004179 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 657317004180 active site residue [active] 657317004181 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 657317004182 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 657317004183 Ligand Binding Site [chemical binding]; other site 657317004184 asparagine synthetase AsnA; Provisional; Region: PRK05425 657317004185 motif 1; other site 657317004186 dimer interface [polypeptide binding]; other site 657317004187 active site 657317004188 motif 2; other site 657317004189 motif 3; other site 657317004190 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 657317004191 putative active site [active] 657317004192 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 657317004193 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 657317004194 dimerization interface [polypeptide binding]; other site 657317004195 domain crossover interface; other site 657317004196 redox-dependent activation switch; other site 657317004197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317004198 Accessory gene regulator B; Region: AgrB; pfam04647 657317004199 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 657317004200 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317004201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317004202 active site 657317004203 phosphorylation site [posttranslational modification] 657317004204 intermolecular recognition site; other site 657317004205 dimerization interface [polypeptide binding]; other site 657317004206 LytTr DNA-binding domain; Region: LytTR; pfam04397 657317004207 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 657317004208 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 657317004209 active site 657317004210 active site 657317004211 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 657317004212 Domain of unknown function, E. rectale Gene description (DUF3879); Region: DUF3879; pfam12995 657317004213 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 657317004214 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 657317004215 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 657317004216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317004217 Walker A/P-loop; other site 657317004218 ATP binding site [chemical binding]; other site 657317004219 Q-loop/lid; other site 657317004220 ABC transporter signature motif; other site 657317004221 Walker B; other site 657317004222 D-loop; other site 657317004223 H-loop/switch region; other site 657317004224 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 657317004225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317004226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317004227 active site 657317004228 phosphorylation site [posttranslational modification] 657317004229 intermolecular recognition site; other site 657317004230 dimerization interface [polypeptide binding]; other site 657317004231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317004232 DNA binding site [nucleotide binding] 657317004233 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 657317004234 active site 657317004235 catalytic residues [active] 657317004236 metal binding site [ion binding]; metal-binding site 657317004237 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK14654 657317004238 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 657317004239 Mg++ binding site [ion binding]; other site 657317004240 putative catalytic motif [active] 657317004241 putative substrate binding site [chemical binding]; other site 657317004242 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317004243 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317004244 DNA binding site [nucleotide binding] 657317004245 domain linker motif; other site 657317004246 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317004247 ligand binding site [chemical binding]; other site 657317004248 dimerization interface [polypeptide binding]; other site 657317004249 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 657317004250 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 657317004251 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 657317004252 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 657317004253 active site 657317004254 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 657317004255 DHH family; Region: DHH; pfam01368 657317004256 DHHA1 domain; Region: DHHA1; pfam02272 657317004257 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 657317004258 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 657317004259 dimerization interface 3.5A [polypeptide binding]; other site 657317004260 active site 657317004261 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 657317004262 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 657317004263 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 657317004264 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 657317004265 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 657317004266 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 657317004267 putative valine binding site [chemical binding]; other site 657317004268 dimer interface [polypeptide binding]; other site 657317004269 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 657317004270 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 657317004271 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 657317004272 PYR/PP interface [polypeptide binding]; other site 657317004273 dimer interface [polypeptide binding]; other site 657317004274 TPP binding site [chemical binding]; other site 657317004275 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 657317004276 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 657317004277 TPP-binding site [chemical binding]; other site 657317004278 dimer interface [polypeptide binding]; other site 657317004279 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 657317004280 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 657317004281 folate binding site [chemical binding]; other site 657317004282 NADP+ binding site [chemical binding]; other site 657317004283 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 657317004284 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 657317004285 dimerization interface [polypeptide binding]; other site 657317004286 active site 657317004287 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 657317004288 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 657317004289 FMN binding site [chemical binding]; other site 657317004290 active site 657317004291 catalytic residues [active] 657317004292 substrate binding site [chemical binding]; other site 657317004293 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 657317004294 classical (c) SDRs; Region: SDR_c; cd05233 657317004295 NAD(P) binding site [chemical binding]; other site 657317004296 active site 657317004297 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 657317004298 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 657317004299 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 657317004300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317004301 AAA domain; Region: AAA_22; pfam13401 657317004302 Walker A motif; other site 657317004303 ATP binding site [chemical binding]; other site 657317004304 Walker B motif; other site 657317004305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 657317004306 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 657317004307 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 657317004308 metal ion-dependent adhesion site (MIDAS); other site 657317004309 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317004310 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 657317004311 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 657317004312 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657317004313 Soluble P-type ATPase [General function prediction only]; Region: COG4087 657317004314 Hemerythrin; Region: Hemerythrin; cd12107 657317004315 Fe binding site [ion binding]; other site 657317004316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317004317 Zn2+ binding site [ion binding]; other site 657317004318 Mg2+ binding site [ion binding]; other site 657317004319 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317004320 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317004321 Zn2+ binding site [ion binding]; other site 657317004322 Mg2+ binding site [ion binding]; other site 657317004323 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 657317004324 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 657317004325 4Fe-4S binding domain; Region: Fer4; pfam00037 657317004326 4Fe-4S binding domain; Region: Fer4_6; pfam12837 657317004327 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 657317004328 Protein of unknown function (DUF328); Region: DUF328; pfam03883 657317004329 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 657317004330 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 657317004331 catalytic triad [active] 657317004332 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 657317004333 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 657317004334 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 657317004335 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 657317004336 ligand binding site [chemical binding]; other site 657317004337 flexible hinge region; other site 657317004338 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 657317004339 putative switch regulator; other site 657317004340 non-specific DNA interactions [nucleotide binding]; other site 657317004341 DNA binding site [nucleotide binding] 657317004342 sequence specific DNA binding site [nucleotide binding]; other site 657317004343 putative cAMP binding site [chemical binding]; other site 657317004344 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 657317004345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657317004346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 657317004347 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 657317004348 active site residue [active] 657317004349 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 657317004350 active site residue [active] 657317004351 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657317004352 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 657317004353 catalytic residues [active] 657317004354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 657317004355 Hemerythrin; Region: Hemerythrin; cd12107 657317004356 Fe binding site [ion binding]; other site 657317004357 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 657317004358 substrate binding site [chemical binding]; other site 657317004359 THF binding site; other site 657317004360 zinc-binding site [ion binding]; other site 657317004361 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 657317004362 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 657317004363 transmembrane helices; other site 657317004364 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 657317004365 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 657317004366 ligand binding site [chemical binding]; other site 657317004367 NAD binding site [chemical binding]; other site 657317004368 dimerization interface [polypeptide binding]; other site 657317004369 catalytic site [active] 657317004370 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 657317004371 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 657317004372 inhibitor site; inhibition site 657317004373 active site 657317004374 dimer interface [polypeptide binding]; other site 657317004375 catalytic residue [active] 657317004376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 657317004377 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 657317004378 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 657317004379 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 657317004380 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 657317004381 putative active site [active] 657317004382 metal binding site [ion binding]; metal-binding site 657317004383 Propionate catabolism activator; Region: PrpR_N; pfam06506 657317004384 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657317004385 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 657317004386 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 657317004387 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 657317004388 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 657317004389 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 657317004390 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 657317004391 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 657317004392 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 657317004393 heterotetramer interface [polypeptide binding]; other site 657317004394 active site pocket [active] 657317004395 cleavage site 657317004396 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 657317004397 dimer interface [polypeptide binding]; other site 657317004398 Citrate synthase; Region: Citrate_synt; pfam00285 657317004399 active site 657317004400 citrylCoA binding site [chemical binding]; other site 657317004401 oxalacetate/citrate binding site [chemical binding]; other site 657317004402 coenzyme A binding site [chemical binding]; other site 657317004403 catalytic triad [active] 657317004404 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 657317004405 active site 657317004406 catalytic triad [active] 657317004407 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 657317004408 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657317004409 active site 657317004410 metal binding site [ion binding]; metal-binding site 657317004411 DNA binding site [nucleotide binding] 657317004412 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 657317004413 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 657317004414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317004415 Walker A motif; other site 657317004416 ATP binding site [chemical binding]; other site 657317004417 Walker B motif; other site 657317004418 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657317004419 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 657317004420 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 657317004421 GatB domain; Region: GatB_Yqey; smart00845 657317004422 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 657317004423 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 657317004424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 657317004425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 657317004426 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 657317004427 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 657317004428 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 657317004429 Dimer interface [polypeptide binding]; other site 657317004430 anticodon binding site; other site 657317004431 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 657317004432 homodimer interface [polypeptide binding]; other site 657317004433 motif 1; other site 657317004434 motif 2; other site 657317004435 active site 657317004436 motif 3; other site 657317004437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317004438 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 657317004439 active site 657317004440 motif I; other site 657317004441 motif II; other site 657317004442 Part of AAA domain; Region: AAA_19; pfam13245 657317004443 Family description; Region: UvrD_C_2; pfam13538 657317004444 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 657317004445 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 657317004446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317004447 motif II; other site 657317004448 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 657317004449 putative deacylase active site [active] 657317004450 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 657317004451 Low molecular weight phosphatase family; Region: LMWPc; cd00115 657317004452 active site 657317004453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317004454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004455 non-specific DNA binding site [nucleotide binding]; other site 657317004456 salt bridge; other site 657317004457 sequence-specific DNA binding site [nucleotide binding]; other site 657317004458 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 657317004459 nucleotide binding site [chemical binding]; other site 657317004460 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 657317004461 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 657317004462 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317004463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004464 non-specific DNA binding site [nucleotide binding]; other site 657317004465 salt bridge; other site 657317004466 sequence-specific DNA binding site [nucleotide binding]; other site 657317004467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004468 non-specific DNA binding site [nucleotide binding]; other site 657317004469 salt bridge; other site 657317004470 sequence-specific DNA binding site [nucleotide binding]; other site 657317004471 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317004472 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317004473 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657317004474 Beta-lactamase; Region: Beta-lactamase; pfam00144 657317004475 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 657317004476 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 657317004477 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 657317004478 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317004479 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317004480 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317004481 catalytic residues [active] 657317004482 catalytic nucleophile [active] 657317004483 Recombinase; Region: Recombinase; pfam07508 657317004484 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317004485 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317004486 catalytic residues [active] 657317004487 catalytic nucleophile [active] 657317004488 Recombinase; Region: Recombinase; pfam07508 657317004489 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317004490 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 657317004491 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 657317004492 catalytic residues [active] 657317004493 catalytic nucleophile [active] 657317004494 Recombinase; Region: Recombinase; pfam07508 657317004495 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 657317004496 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 657317004497 PemK-like protein; Region: PemK; pfam02452 657317004498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317004499 DNA binding residues [nucleotide binding] 657317004500 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 657317004501 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317004502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004503 non-specific DNA binding site [nucleotide binding]; other site 657317004504 salt bridge; other site 657317004505 sequence-specific DNA binding site [nucleotide binding]; other site 657317004506 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 657317004507 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 657317004508 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317004509 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 657317004510 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 657317004511 Int/Topo IB signature motif; other site 657317004512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317004513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004514 non-specific DNA binding site [nucleotide binding]; other site 657317004515 salt bridge; other site 657317004516 sequence-specific DNA binding site [nucleotide binding]; other site 657317004517 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 657317004518 Accessory gene regulator B; Region: AgrB; pfam04647 657317004519 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317004521 active site 657317004522 phosphorylation site [posttranslational modification] 657317004523 intermolecular recognition site; other site 657317004524 dimerization interface [polypeptide binding]; other site 657317004525 LytTr DNA-binding domain; Region: LytTR; pfam04397 657317004526 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 657317004527 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 657317004528 active site 657317004529 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 657317004530 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317004531 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317004532 Walker A/P-loop; other site 657317004533 ATP binding site [chemical binding]; other site 657317004534 Q-loop/lid; other site 657317004535 ABC transporter signature motif; other site 657317004536 Walker B; other site 657317004537 D-loop; other site 657317004538 H-loop/switch region; other site 657317004539 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317004540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004541 non-specific DNA binding site [nucleotide binding]; other site 657317004542 salt bridge; other site 657317004543 sequence-specific DNA binding site [nucleotide binding]; other site 657317004544 Predicted transcriptional regulator [Transcription]; Region: COG2932 657317004545 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 657317004546 Catalytic site [active] 657317004547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317004548 non-specific DNA binding site [nucleotide binding]; other site 657317004549 salt bridge; other site 657317004550 sequence-specific DNA binding site [nucleotide binding]; other site 657317004551 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 657317004552 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 657317004553 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 657317004554 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 657317004555 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 657317004556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317004557 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 657317004558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317004559 Walker A/P-loop; other site 657317004560 ATP binding site [chemical binding]; other site 657317004561 Q-loop/lid; other site 657317004562 ABC transporter signature motif; other site 657317004563 Walker B; other site 657317004564 D-loop; other site 657317004565 H-loop/switch region; other site 657317004566 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317004567 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317004568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317004569 Walker A/P-loop; other site 657317004570 ATP binding site [chemical binding]; other site 657317004571 Q-loop/lid; other site 657317004572 ABC transporter signature motif; other site 657317004573 Walker B; other site 657317004574 D-loop; other site 657317004575 H-loop/switch region; other site 657317004576 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657317004577 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 657317004578 Walker A/P-loop; other site 657317004579 ATP binding site [chemical binding]; other site 657317004580 Q-loop/lid; other site 657317004581 ABC transporter signature motif; other site 657317004582 Walker B; other site 657317004583 D-loop; other site 657317004584 H-loop/switch region; other site 657317004585 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657317004586 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 657317004587 Walker A/P-loop; other site 657317004588 ATP binding site [chemical binding]; other site 657317004589 Q-loop/lid; other site 657317004590 ABC transporter signature motif; other site 657317004591 Walker B; other site 657317004592 D-loop; other site 657317004593 H-loop/switch region; other site 657317004594 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 657317004595 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 657317004596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317004597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317004598 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 657317004599 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 657317004600 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 657317004601 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 657317004602 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 657317004603 cofactor binding site; other site 657317004604 DNA binding site [nucleotide binding] 657317004605 substrate interaction site [chemical binding]; other site 657317004606 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 657317004607 non-specific DNA binding site [nucleotide binding]; other site 657317004608 salt bridge; other site 657317004609 sequence-specific DNA binding site [nucleotide binding]; other site 657317004610 Cupin domain; Region: Cupin_2; cl17218 657317004611 Ferredoxin [Energy production and conversion]; Region: COG1146 657317004612 4Fe-4S binding domain; Region: Fer4_6; pfam12837 657317004613 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657317004614 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657317004615 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 657317004616 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 657317004617 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 657317004618 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 657317004619 active site 657317004620 SAM binding site [chemical binding]; other site 657317004621 homodimer interface [polypeptide binding]; other site 657317004622 Y-family of DNA polymerases; Region: PolY; cl12025 657317004623 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 657317004624 active site 657317004625 Y-family of DNA polymerases; Region: PolY; cl12025 657317004626 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 657317004627 DNA binding site [nucleotide binding] 657317004628 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 657317004629 PAS domain; Region: PAS_9; pfam13426 657317004630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317004631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317004632 metal binding site [ion binding]; metal-binding site 657317004633 active site 657317004634 I-site; other site 657317004635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317004636 metal binding site [ion binding]; metal-binding site 657317004637 active site 657317004638 I-site; other site 657317004639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317004640 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657317004641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 657317004642 motif II; other site 657317004643 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 657317004644 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 657317004645 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 657317004646 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 657317004647 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 657317004648 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 657317004649 active site 657317004650 substrate binding site [chemical binding]; other site 657317004651 cosubstrate binding site; other site 657317004652 catalytic site [active] 657317004653 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 657317004654 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 657317004655 dimerization interface [polypeptide binding]; other site 657317004656 putative ATP binding site [chemical binding]; other site 657317004657 Uncharacterized conserved protein [Function unknown]; Region: COG1284 657317004658 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 657317004659 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 657317004660 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 657317004661 HicB family; Region: HicB; pfam05534 657317004662 YcfA-like protein; Region: YcfA; cl00752 657317004663 seryl-tRNA synthetase; Provisional; Region: PRK05431 657317004664 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 657317004665 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657317004666 motif 1; other site 657317004667 dimer interface [polypeptide binding]; other site 657317004668 active site 657317004669 motif 2; other site 657317004670 motif 3; other site 657317004671 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 657317004672 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 657317004673 dimer interface [polypeptide binding]; other site 657317004674 active site 657317004675 glycine-pyridoxal phosphate binding site [chemical binding]; other site 657317004676 folate binding site [chemical binding]; other site 657317004677 SpoVA protein; Region: SpoVA; pfam03862 657317004678 Cupin domain; Region: Cupin_2; pfam07883 657317004679 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317004680 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657317004681 YcfA-like protein; Region: YcfA; pfam07927 657317004682 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 657317004683 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657317004684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657317004685 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 657317004686 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 657317004687 dimer interface [polypeptide binding]; other site 657317004688 active site 657317004689 metal binding site [ion binding]; metal-binding site 657317004690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317004691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317004692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657317004693 dimerization interface [polypeptide binding]; other site 657317004694 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 657317004695 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 657317004696 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 657317004697 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 657317004698 GDP-binding site [chemical binding]; other site 657317004699 ACT binding site; other site 657317004700 IMP binding site; other site 657317004701 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 657317004702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657317004703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317004704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317004705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657317004706 dimerization interface [polypeptide binding]; other site 657317004707 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 657317004708 Sel1-like repeats; Region: SEL1; smart00671 657317004709 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 657317004710 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 657317004711 active site 657317004712 catalytic site [active] 657317004713 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 657317004714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317004715 FeS/SAM binding site; other site 657317004716 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 657317004717 EamA-like transporter family; Region: EamA; pfam00892 657317004718 EamA-like transporter family; Region: EamA; pfam00892 657317004719 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317004720 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317004721 DNA binding site [nucleotide binding] 657317004722 domain linker motif; other site 657317004723 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317004724 dimerization interface [polypeptide binding]; other site 657317004725 ligand binding site [chemical binding]; other site 657317004726 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 657317004727 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 657317004728 catalytic domain interface [polypeptide binding]; other site 657317004729 homodimer interface [polypeptide binding]; other site 657317004730 putative active site [active] 657317004731 Domain of unknown function (DUF3837); Region: DUF3837; pfam12939 657317004732 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 657317004733 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 657317004734 Uncharacterized conserved protein [Function unknown]; Region: COG2966 657317004735 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 657317004736 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 657317004737 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657317004738 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317004739 ABC transporter; Region: ABC_tran_2; pfam12848 657317004740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317004741 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 657317004742 synthetase active site [active] 657317004743 NTP binding site [chemical binding]; other site 657317004744 metal binding site [ion binding]; metal-binding site 657317004745 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 657317004746 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 657317004747 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657317004748 6-phosphofructokinase; Provisional; Region: PRK03202 657317004749 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 657317004750 active site 657317004751 ADP/pyrophosphate binding site [chemical binding]; other site 657317004752 dimerization interface [polypeptide binding]; other site 657317004753 allosteric effector site; other site 657317004754 fructose-1,6-bisphosphate binding site; other site 657317004755 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 657317004756 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 657317004757 active site 657317004758 PHP Thumb interface [polypeptide binding]; other site 657317004759 metal binding site [ion binding]; metal-binding site 657317004760 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 657317004761 generic binding surface II; other site 657317004762 generic binding surface I; other site 657317004763 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 657317004764 homodimer interface [polypeptide binding]; other site 657317004765 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 657317004766 active site pocket [active] 657317004767 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 657317004768 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 657317004769 HIGH motif; other site 657317004770 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 657317004771 active site 657317004772 KMSKS motif; other site 657317004773 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 657317004774 tRNA binding surface [nucleotide binding]; other site 657317004775 anticodon binding site; other site 657317004776 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657317004777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317004778 dimer interface [polypeptide binding]; other site 657317004779 putative CheW interface [polypeptide binding]; other site 657317004780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317004781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317004782 dimer interface [polypeptide binding]; other site 657317004783 conserved gate region; other site 657317004784 ABC-ATPase subunit interface; other site 657317004785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317004786 Response regulator receiver domain; Region: Response_reg; pfam00072 657317004787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317004788 active site 657317004789 phosphorylation site [posttranslational modification] 657317004790 intermolecular recognition site; other site 657317004791 dimerization interface [polypeptide binding]; other site 657317004792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317004793 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317004794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317004795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317004796 HAMP domain; Region: HAMP; pfam00672 657317004797 Histidine kinase; Region: His_kinase; pfam06580 657317004798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317004799 ATP binding site [chemical binding]; other site 657317004800 Mg2+ binding site [ion binding]; other site 657317004801 G-X-G motif; other site 657317004802 Probable beta-xylosidase; Provisional; Region: PLN03080 657317004803 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 657317004804 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 657317004805 Cupin domain; Region: Cupin_2; pfam07883 657317004806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317004807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317004808 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 657317004809 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 657317004810 inhibitor binding site; inhibition site 657317004811 active site 657317004812 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 657317004813 active site 657317004814 catalytic triad [active] 657317004815 oxyanion hole [active] 657317004816 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 657317004817 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 657317004818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317004819 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 657317004820 HTH domain; Region: HTH_11; pfam08279 657317004821 3H domain; Region: 3H; pfam02829 657317004822 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 657317004823 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 657317004824 dimerization interface [polypeptide binding]; other site 657317004825 active site 657317004826 L-aspartate oxidase; Provisional; Region: PRK06175 657317004827 FAD binding domain; Region: FAD_binding_2; pfam00890 657317004828 Quinolinate synthetase A protein; Region: NadA; pfam02445 657317004829 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 657317004830 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 657317004831 active site 657317004832 NTP binding site [chemical binding]; other site 657317004833 metal binding triad [ion binding]; metal-binding site 657317004834 antibiotic binding site [chemical binding]; other site 657317004835 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 657317004836 active site 657317004837 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 657317004838 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 657317004839 acyl-activating enzyme (AAE) consensus motif; other site 657317004840 putative AMP binding site [chemical binding]; other site 657317004841 putative active site [active] 657317004842 putative CoA binding site [chemical binding]; other site 657317004843 acyl carrier protein; Provisional; Region: acpP; PRK00982 657317004844 Condensation domain; Region: Condensation; pfam00668 657317004845 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 657317004846 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 657317004847 SCP-2 sterol transfer family; Region: SCP2; pfam02036 657317004848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 657317004849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 657317004850 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 657317004851 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 657317004852 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657317004853 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317004854 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 657317004855 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 657317004856 substrate binding site [chemical binding]; other site 657317004857 oxyanion hole (OAH) forming residues; other site 657317004858 trimer interface [polypeptide binding]; other site 657317004859 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 657317004860 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 657317004861 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 657317004862 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 657317004863 active site 657317004864 catalytic site [active] 657317004865 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 657317004866 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 657317004867 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 657317004868 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 657317004869 Protein export membrane protein; Region: SecD_SecF; pfam02355 657317004870 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 657317004871 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 657317004872 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 657317004873 putative dimer interface [polypeptide binding]; other site 657317004874 putative anticodon binding site; other site 657317004875 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 657317004876 homodimer interface [polypeptide binding]; other site 657317004877 motif 1; other site 657317004878 motif 2; other site 657317004879 active site 657317004880 motif 3; other site 657317004881 trigger factor; Region: tig; TIGR00115 657317004882 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657317004883 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 657317004884 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657317004885 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317004886 dimerization interface [polypeptide binding]; other site 657317004887 ligand binding site [chemical binding]; other site 657317004888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317004889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317004890 metal binding site [ion binding]; metal-binding site 657317004891 active site 657317004892 I-site; other site 657317004893 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 657317004894 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 657317004895 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 657317004896 Spore germination protein; Region: Spore_permease; cl17796 657317004897 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 657317004898 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 657317004899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317004900 DNA-binding site [nucleotide binding]; DNA binding site 657317004901 Transcriptional regulators [Transcription]; Region: FadR; COG2186 657317004902 FCD domain; Region: FCD; pfam07729 657317004903 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 657317004904 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 657317004905 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 657317004906 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 657317004907 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 657317004908 dimerization interface [polypeptide binding]; other site 657317004909 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317004910 dimer interface [polypeptide binding]; other site 657317004911 putative CheW interface [polypeptide binding]; other site 657317004912 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 657317004913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657317004914 ABC-ATPase subunit interface; other site 657317004915 dimer interface [polypeptide binding]; other site 657317004916 putative PBP binding regions; other site 657317004917 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 657317004918 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 657317004919 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 657317004920 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 657317004921 intersubunit interface [polypeptide binding]; other site 657317004922 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 657317004923 G1 box; other site 657317004924 GTP/Mg2+ binding site [chemical binding]; other site 657317004925 Switch I region; other site 657317004926 G2 box; other site 657317004927 G3 box; other site 657317004928 Switch II region; other site 657317004929 G4 box; other site 657317004930 G5 box; other site 657317004931 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 657317004932 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 657317004933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317004934 Walker A motif; other site 657317004935 ATP binding site [chemical binding]; other site 657317004936 Walker B motif; other site 657317004937 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 657317004938 Clp protease; Region: CLP_protease; pfam00574 657317004939 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 657317004940 oligomer interface [polypeptide binding]; other site 657317004941 active site residues [active] 657317004942 trigger factor; Provisional; Region: tig; PRK01490 657317004943 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 657317004944 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 657317004945 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 657317004946 DJ-1 family protein; Region: not_thiJ; TIGR01383 657317004947 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 657317004948 conserved cys residue [active] 657317004949 Clostridium thermocellum (Cth)TTM and similar proteins, a subgroup of the CYTH-like superfamily; Region: CYTH-like_CthTTM-like; cd07761 657317004950 putative active site [active] 657317004951 putative metal binding residues [ion binding]; other site 657317004952 signature motif; other site 657317004953 putative dimer interface [polypeptide binding]; other site 657317004954 putative phosphate binding site [ion binding]; other site 657317004955 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 657317004956 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 657317004957 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 657317004958 peptide binding site [polypeptide binding]; other site 657317004959 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 657317004960 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 657317004961 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657317004962 Walker A/P-loop; other site 657317004963 ATP binding site [chemical binding]; other site 657317004964 Q-loop/lid; other site 657317004965 ABC transporter signature motif; other site 657317004966 Walker B; other site 657317004967 D-loop; other site 657317004968 H-loop/switch region; other site 657317004969 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 657317004970 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 657317004971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 657317004972 Walker A/P-loop; other site 657317004973 ATP binding site [chemical binding]; other site 657317004974 Q-loop/lid; other site 657317004975 ABC transporter signature motif; other site 657317004976 Walker B; other site 657317004977 D-loop; other site 657317004978 H-loop/switch region; other site 657317004979 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 657317004980 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 657317004981 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 657317004982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317004983 dimer interface [polypeptide binding]; other site 657317004984 conserved gate region; other site 657317004985 putative PBP binding loops; other site 657317004986 ABC-ATPase subunit interface; other site 657317004987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 657317004988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317004989 dimer interface [polypeptide binding]; other site 657317004990 conserved gate region; other site 657317004991 putative PBP binding loops; other site 657317004992 ABC-ATPase subunit interface; other site 657317004993 Domain of unknown function, E. rectale Gene description (DUF3878); Region: DUF3878; pfam12994 657317004994 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317004995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317004996 dimer interface [polypeptide binding]; other site 657317004997 phosphorylation site [posttranslational modification] 657317004998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317004999 ATP binding site [chemical binding]; other site 657317005000 Mg2+ binding site [ion binding]; other site 657317005001 G-X-G motif; other site 657317005002 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657317005003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317005004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317005005 active site 657317005006 phosphorylation site [posttranslational modification] 657317005007 intermolecular recognition site; other site 657317005008 dimerization interface [polypeptide binding]; other site 657317005009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317005010 DNA binding site [nucleotide binding] 657317005011 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 657317005012 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657317005013 active site 657317005014 metal binding site [ion binding]; metal-binding site 657317005015 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317005016 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317005017 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 657317005018 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 657317005019 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 657317005020 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 657317005021 HlyD family secretion protein; Region: HlyD_3; pfam13437 657317005022 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 657317005023 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317005024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317005025 active site 657317005026 phosphorylation site [posttranslational modification] 657317005027 intermolecular recognition site; other site 657317005028 dimerization interface [polypeptide binding]; other site 657317005029 LytTr DNA-binding domain; Region: LytTR; smart00850 657317005030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317005031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317005032 Walker A/P-loop; other site 657317005033 ATP binding site [chemical binding]; other site 657317005034 Q-loop/lid; other site 657317005035 ABC transporter signature motif; other site 657317005036 Walker B; other site 657317005037 D-loop; other site 657317005038 H-loop/switch region; other site 657317005039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317005040 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 657317005041 Walker A/P-loop; other site 657317005042 ATP binding site [chemical binding]; other site 657317005043 Q-loop/lid; other site 657317005044 ABC transporter signature motif; other site 657317005045 Walker B; other site 657317005046 D-loop; other site 657317005047 H-loop/switch region; other site 657317005048 FtsX-like permease family; Region: FtsX; pfam02687 657317005049 FtsX-like permease family; Region: FtsX; pfam02687 657317005050 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 657317005051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 657317005052 Virulence protein [General function prediction only]; Region: COG3943 657317005053 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 657317005054 SnoaL-like domain; Region: SnoaL_2; pfam12680 657317005055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317005056 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317005057 dimerization interface [polypeptide binding]; other site 657317005058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317005059 dimer interface [polypeptide binding]; other site 657317005060 phosphorylation site [posttranslational modification] 657317005061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317005062 ATP binding site [chemical binding]; other site 657317005063 Mg2+ binding site [ion binding]; other site 657317005064 G-X-G motif; other site 657317005065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317005066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317005067 active site 657317005068 phosphorylation site [posttranslational modification] 657317005069 intermolecular recognition site; other site 657317005070 dimerization interface [polypeptide binding]; other site 657317005071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317005072 DNA binding site [nucleotide binding] 657317005073 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 657317005074 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 657317005075 biotin synthase; Region: bioB; TIGR00433 657317005076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317005077 FeS/SAM binding site; other site 657317005078 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 657317005079 Predicted membrane protein [Function unknown]; Region: COG2510 657317005080 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 657317005081 Predicted membrane protein [Function unknown]; Region: COG2510 657317005082 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 657317005083 active site 657317005084 dimerization interface [polypeptide binding]; other site 657317005085 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 657317005086 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 657317005087 active site 657317005088 metal binding site [ion binding]; metal-binding site 657317005089 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 657317005090 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 657317005091 active site 657317005092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 657317005093 active site residue [active] 657317005094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317005095 metal binding site [ion binding]; metal-binding site 657317005096 active site 657317005097 I-site; other site 657317005098 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317005099 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657317005100 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657317005101 homodimer interface [polypeptide binding]; other site 657317005102 substrate-cofactor binding pocket; other site 657317005103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317005104 catalytic residue [active] 657317005105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657317005106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 657317005107 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 657317005108 active site 657317005109 SAM binding site [chemical binding]; other site 657317005110 homodimer interface [polypeptide binding]; other site 657317005111 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 657317005112 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 657317005113 active site 657317005114 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 657317005115 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 657317005116 domain interfaces; other site 657317005117 active site 657317005118 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 657317005119 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 657317005120 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 657317005121 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 657317005122 MPN+ (JAMM) motif; other site 657317005123 Zinc-binding site [ion binding]; other site 657317005124 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 657317005125 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 657317005126 ATP binding site [chemical binding]; other site 657317005127 substrate interface [chemical binding]; other site 657317005128 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 657317005129 thiS-thiF/thiG interaction site; other site 657317005130 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 657317005131 catalytic residues [active] 657317005132 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 657317005133 CPxP motif; other site 657317005134 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 657317005135 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 657317005136 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 657317005137 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 657317005138 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 657317005139 homodimer interface [polypeptide binding]; other site 657317005140 substrate-cofactor binding pocket; other site 657317005141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317005142 catalytic residue [active] 657317005143 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 657317005144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 657317005145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 657317005146 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 657317005147 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 657317005148 Ca binding site [ion binding]; other site 657317005149 active site 657317005150 catalytic site [active] 657317005151 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 657317005152 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 657317005153 Ca binding site [ion binding]; other site 657317005154 active site 657317005155 catalytic site [active] 657317005156 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 657317005157 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317005158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317005159 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317005160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317005161 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 657317005162 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 657317005163 metal binding site [ion binding]; metal-binding site 657317005164 dimer interface [polypeptide binding]; other site 657317005165 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 657317005166 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 657317005167 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 657317005168 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 657317005169 active site 657317005170 metal binding site [ion binding]; metal-binding site 657317005171 SseB protein; Region: SseB; cl06279 657317005172 Transposase; Region: DEDD_Tnp_IS110; pfam01548 657317005173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 657317005174 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 657317005175 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 657317005176 TIR domain; Region: TIR_2; pfam13676 657317005177 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 657317005178 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 657317005179 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 657317005180 substrate binding site; other site 657317005181 dimer interface; other site 657317005182 UGMP family protein; Validated; Region: PRK09604 657317005183 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 657317005184 ribonuclease Z; Reviewed; Region: PRK00055 657317005185 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 657317005186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317005187 Coenzyme A binding pocket [chemical binding]; other site 657317005188 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 657317005189 Glycoprotease family; Region: Peptidase_M22; pfam00814 657317005190 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 657317005191 YcxB-like protein; Region: YcxB; pfam14317 657317005192 Predicted membrane protein [Function unknown]; Region: COG3601 657317005193 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657317005194 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 657317005195 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 657317005196 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 657317005197 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 657317005198 RNA binding site [nucleotide binding]; other site 657317005199 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 657317005200 Protein of unknown function (DUF975); Region: DUF975; cl10504 657317005201 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 657317005202 Flavoprotein; Region: Flavoprotein; pfam02441 657317005203 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 657317005204 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 657317005205 putative active site pocket [active] 657317005206 cleavage site 657317005207 Predicted membrane protein [Function unknown]; Region: COG4684 657317005208 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 657317005209 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 657317005210 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 657317005211 glutaminase active site [active] 657317005212 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 657317005213 dimer interface [polypeptide binding]; other site 657317005214 active site 657317005215 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 657317005216 dimer interface [polypeptide binding]; other site 657317005217 active site 657317005218 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 657317005219 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 657317005220 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 657317005221 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 657317005222 Ligand binding site [chemical binding]; other site 657317005223 Electron transfer flavoprotein domain; Region: ETF; pfam01012 657317005224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 657317005225 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 657317005226 FAD binding site [chemical binding]; other site 657317005227 homotetramer interface [polypeptide binding]; other site 657317005228 substrate binding pocket [chemical binding]; other site 657317005229 catalytic base [active] 657317005230 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 657317005231 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 657317005232 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 657317005233 putative acyltransferase; Provisional; Region: PRK05790 657317005234 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 657317005235 dimer interface [polypeptide binding]; other site 657317005236 active site 657317005237 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 657317005238 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657317005239 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 657317005240 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 657317005241 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 657317005242 ATP-grasp domain; Region: ATP-grasp_4; cl17255 657317005243 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 657317005244 IMP binding site; other site 657317005245 dimer interface [polypeptide binding]; other site 657317005246 interdomain contacts; other site 657317005247 partial ornithine binding site; other site 657317005248 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 657317005249 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 657317005250 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 657317005251 catalytic site [active] 657317005252 subunit interface [polypeptide binding]; other site 657317005253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657317005254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317005255 Coenzyme A binding pocket [chemical binding]; other site 657317005256 Rod binding protein; Region: Rod-binding; cl01626 657317005257 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 657317005258 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657317005259 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657317005260 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 657317005261 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 657317005262 homoserine dehydrogenase; Provisional; Region: PRK06349 657317005263 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 657317005264 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 657317005265 hypothetical protein; Provisional; Region: PRK04435 657317005266 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 657317005267 DNA-binding interface [nucleotide binding]; DNA binding site 657317005268 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 657317005269 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 657317005270 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 657317005271 peptide chain release factor 2; Provisional; Region: PRK05589 657317005272 PCRF domain; Region: PCRF; pfam03462 657317005273 RF-1 domain; Region: RF-1; pfam00472 657317005274 Predicted integral membrane protein [Function unknown]; Region: COG5652 657317005275 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 657317005276 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 657317005277 protein binding site [polypeptide binding]; other site 657317005278 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 657317005279 Catalytic dyad [active] 657317005280 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 657317005281 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 657317005282 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 657317005283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317005284 Walker A/P-loop; other site 657317005285 ATP binding site [chemical binding]; other site 657317005286 Q-loop/lid; other site 657317005287 ABC transporter signature motif; other site 657317005288 Walker B; other site 657317005289 D-loop; other site 657317005290 H-loop/switch region; other site 657317005291 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 657317005292 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657317005293 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 657317005294 Bacterial SH3 domain; Region: SH3_3; pfam08239 657317005295 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657317005296 NlpC/P60 family; Region: NLPC_P60; pfam00877 657317005297 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 657317005298 homotrimer interaction site [polypeptide binding]; other site 657317005299 putative active site [active] 657317005300 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 657317005301 S1 domain; Region: S1_2; pfam13509 657317005302 S1 domain; Region: S1_2; pfam13509 657317005303 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 657317005304 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 657317005305 active site 657317005306 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 657317005307 Uncharacterized conserved protein [Function unknown]; Region: COG1739 657317005308 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 657317005309 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 657317005310 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 657317005311 Transglycosylase; Region: Transgly; pfam00912 657317005312 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 657317005313 ammonium transporter; Region: amt; TIGR00836 657317005314 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 657317005315 Nitrogen regulatory protein P-II; Region: P-II; smart00938 657317005316 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 657317005317 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 657317005318 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 657317005319 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 657317005320 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 657317005321 intersubunit interface [polypeptide binding]; other site 657317005322 active site 657317005323 zinc binding site [ion binding]; other site 657317005324 Na+ binding site [ion binding]; other site 657317005325 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 657317005326 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 657317005327 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 657317005328 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 657317005329 FAD binding domain; Region: FAD_binding_4; pfam01565 657317005330 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 657317005331 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 657317005332 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 657317005333 oligomer interface [polypeptide binding]; other site 657317005334 putative active site [active] 657317005335 metal binding site [ion binding]; metal-binding site 657317005336 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 657317005337 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 657317005338 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 657317005339 Hpr binding site; other site 657317005340 active site 657317005341 homohexamer subunit interaction site [polypeptide binding]; other site 657317005342 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 657317005343 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 657317005344 GIY-YIG motif/motif A; other site 657317005345 active site 657317005346 catalytic site [active] 657317005347 putative DNA binding site [nucleotide binding]; other site 657317005348 metal binding site [ion binding]; metal-binding site 657317005349 UvrB/uvrC motif; Region: UVR; pfam02151 657317005350 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 657317005351 FtsH Extracellular; Region: FtsH_ext; pfam06480 657317005352 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 657317005353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317005354 Walker A motif; other site 657317005355 ATP binding site [chemical binding]; other site 657317005356 Walker B motif; other site 657317005357 arginine finger; other site 657317005358 Peptidase family M41; Region: Peptidase_M41; pfam01434 657317005359 CTP synthetase; Validated; Region: pyrG; PRK05380 657317005360 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 657317005361 Catalytic site [active] 657317005362 active site 657317005363 UTP binding site [chemical binding]; other site 657317005364 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 657317005365 active site 657317005366 putative oxyanion hole; other site 657317005367 catalytic triad [active] 657317005368 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 657317005369 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 657317005370 nudix motif; other site 657317005371 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 657317005372 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 657317005373 minor groove reading motif; other site 657317005374 helix-hairpin-helix signature motif; other site 657317005375 substrate binding pocket [chemical binding]; other site 657317005376 active site 657317005377 glutamate racemase; Provisional; Region: PRK00865 657317005378 flagellar operon protein TIGR03826; Region: YvyF 657317005379 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 657317005380 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 657317005381 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 657317005382 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 657317005383 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 657317005384 FMN binding site [chemical binding]; other site 657317005385 substrate binding site [chemical binding]; other site 657317005386 putative catalytic residue [active] 657317005387 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657317005388 active site 657317005389 regulatory protein interface [polypeptide binding]; other site 657317005390 regulatory phosphorylation site [posttranslational modification]; other site 657317005391 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 657317005392 EamA-like transporter family; Region: EamA; cl17759 657317005393 Bacterial SH3 domain; Region: SH3_3; pfam08239 657317005394 Beta-lactamase; Region: Beta-lactamase; pfam00144 657317005395 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 657317005396 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 657317005397 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 657317005398 intersubunit interface [polypeptide binding]; other site 657317005399 active site 657317005400 Zn2+ binding site [ion binding]; other site 657317005401 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 657317005402 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 657317005403 putative N- and C-terminal domain interface [polypeptide binding]; other site 657317005404 putative active site [active] 657317005405 MgATP binding site [chemical binding]; other site 657317005406 catalytic site [active] 657317005407 metal binding site [ion binding]; metal-binding site 657317005408 putative carbohydrate binding site [chemical binding]; other site 657317005409 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 657317005410 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 657317005411 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 657317005412 PhoU domain; Region: PhoU; pfam01895 657317005413 PhoU domain; Region: PhoU; pfam01895 657317005414 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 657317005415 ABC1 family; Region: ABC1; cl17513 657317005416 Uncharacterized conserved protein [Function unknown]; Region: COG3937 657317005417 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 657317005418 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317005419 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 657317005420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 657317005421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 657317005422 active site 657317005423 catalytic tetrad [active] 657317005424 Domain of unknown function DUF128; Region: DUF128; pfam01995 657317005425 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 657317005426 RNA ligase; Region: RNA_ligase; pfam09414 657317005427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317005428 non-specific DNA binding site [nucleotide binding]; other site 657317005429 salt bridge; other site 657317005430 sequence-specific DNA binding site [nucleotide binding]; other site 657317005431 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317005432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317005433 non-specific DNA binding site [nucleotide binding]; other site 657317005434 salt bridge; other site 657317005435 sequence-specific DNA binding site [nucleotide binding]; other site 657317005436 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 657317005437 putative ADP-ribose binding site [chemical binding]; other site 657317005438 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 657317005439 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 657317005440 Putative transposase; Region: Y2_Tnp; pfam04986 657317005441 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 657317005442 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317005443 active site 657317005444 DNA binding site [nucleotide binding] 657317005445 Int/Topo IB signature motif; other site 657317005446 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 657317005447 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 657317005448 4Fe-4S binding domain; Region: Fer4; cl02805 657317005449 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 657317005450 Predicted transcriptional regulator [Transcription]; Region: COG1959 657317005451 Transcriptional regulator; Region: Rrf2; pfam02082 657317005452 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657317005453 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 657317005454 Walker A/P-loop; other site 657317005455 ATP binding site [chemical binding]; other site 657317005456 Q-loop/lid; other site 657317005457 ABC transporter signature motif; other site 657317005458 Walker B; other site 657317005459 D-loop; other site 657317005460 H-loop/switch region; other site 657317005461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317005462 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 657317005463 Walker A/P-loop; other site 657317005464 ATP binding site [chemical binding]; other site 657317005465 Q-loop/lid; other site 657317005466 ABC transporter signature motif; other site 657317005467 Walker B; other site 657317005468 D-loop; other site 657317005469 H-loop/switch region; other site 657317005470 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 657317005471 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 657317005472 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317005473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317005474 Virulence protein [General function prediction only]; Region: COG3943 657317005475 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 657317005476 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 657317005477 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 657317005478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317005479 ATP binding site [chemical binding]; other site 657317005480 putative Mg++ binding site [ion binding]; other site 657317005481 helicase superfamily c-terminal domain; Region: HELICc; smart00490 657317005482 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 657317005483 PLD-like domain; Region: PLDc_2; pfam13091 657317005484 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 657317005485 Divergent AAA domain; Region: AAA_4; pfam04326 657317005486 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 657317005487 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 657317005488 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 657317005489 nudix motif; other site 657317005490 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 657317005491 Part of AAA domain; Region: AAA_19; pfam13245 657317005492 AAA domain; Region: AAA_12; pfam13087 657317005493 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 657317005494 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657317005495 catalytic core [active] 657317005496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317005497 Coenzyme A binding pocket [chemical binding]; other site 657317005498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317005499 non-specific DNA binding site [nucleotide binding]; other site 657317005500 salt bridge; other site 657317005501 sequence-specific DNA binding site [nucleotide binding]; other site 657317005502 Dam-replacing family; Region: DRP; pfam06044 657317005503 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 657317005504 DNA methylase; Region: N6_N4_Mtase; pfam01555 657317005505 integrase; Provisional; Region: int; PHA02601 657317005506 Helix-turn-helix domain; Region: HTH_17; cl17695 657317005507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317005508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317005509 non-specific DNA binding site [nucleotide binding]; other site 657317005510 salt bridge; other site 657317005511 sequence-specific DNA binding site [nucleotide binding]; other site 657317005512 GMP synthase; Reviewed; Region: guaA; PRK00074 657317005513 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 657317005514 AMP/PPi binding site [chemical binding]; other site 657317005515 candidate oxyanion hole; other site 657317005516 catalytic triad [active] 657317005517 potential glutamine specificity residues [chemical binding]; other site 657317005518 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 657317005519 ATP Binding subdomain [chemical binding]; other site 657317005520 Ligand Binding sites [chemical binding]; other site 657317005521 Dimerization subdomain; other site 657317005522 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657317005523 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 657317005524 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 657317005525 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657317005526 metal-binding site [ion binding] 657317005527 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657317005528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317005529 motif II; other site 657317005530 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657317005531 metal-binding site [ion binding] 657317005532 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 657317005533 metal-binding site [ion binding] 657317005534 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 657317005535 putative homodimer interface [polypeptide binding]; other site 657317005536 putative homotetramer interface [polypeptide binding]; other site 657317005537 putative allosteric switch controlling residues; other site 657317005538 putative metal binding site [ion binding]; other site 657317005539 putative homodimer-homodimer interface [polypeptide binding]; other site 657317005540 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 657317005541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317005542 active site 657317005543 phosphorylation site [posttranslational modification] 657317005544 intermolecular recognition site; other site 657317005545 dimerization interface [polypeptide binding]; other site 657317005546 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 657317005547 DNA binding residues [nucleotide binding] 657317005548 dimerization interface [polypeptide binding]; other site 657317005549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317005550 Histidine kinase; Region: HisKA_3; pfam07730 657317005551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317005552 ATP binding site [chemical binding]; other site 657317005553 Mg2+ binding site [ion binding]; other site 657317005554 G-X-G motif; other site 657317005555 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657317005556 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317005557 Walker A/P-loop; other site 657317005558 ATP binding site [chemical binding]; other site 657317005559 Q-loop/lid; other site 657317005560 ABC transporter signature motif; other site 657317005561 Walker B; other site 657317005562 D-loop; other site 657317005563 H-loop/switch region; other site 657317005564 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 657317005565 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 657317005566 ABC-2 type transporter; Region: ABC2_membrane; cl17235 657317005567 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 657317005568 RHS Repeat; Region: RHS_repeat; pfam05593 657317005569 RHS Repeat; Region: RHS_repeat; pfam05593 657317005570 RHS Repeat; Region: RHS_repeat; pfam05593 657317005571 RHS Repeat; Region: RHS_repeat; pfam05593 657317005572 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 657317005573 RHS Repeat; Region: RHS_repeat; pfam05593 657317005574 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 657317005575 RHS Repeat; Region: RHS_repeat; pfam05593 657317005576 RHS Repeat; Region: RHS_repeat; pfam05593 657317005577 RHS Repeat; Region: RHS_repeat; pfam05593 657317005578 RHS Repeat; Region: RHS_repeat; pfam05593 657317005579 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 657317005580 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 657317005581 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 657317005582 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657317005583 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657317005584 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 657317005585 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 657317005586 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 657317005587 phosphopeptide binding site; other site 657317005588 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 657317005589 Catalytic domain of Protein Kinases; Region: PKc; cd00180 657317005590 active site 657317005591 ATP binding site [chemical binding]; other site 657317005592 substrate binding site [chemical binding]; other site 657317005593 activation loop (A-loop); other site 657317005594 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 657317005595 active site 657317005596 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317005597 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 657317005598 aspartate aminotransferase; Provisional; Region: PRK06836 657317005599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317005600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317005601 homodimer interface [polypeptide binding]; other site 657317005602 catalytic residue [active] 657317005603 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 657317005604 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 657317005605 G1 box; other site 657317005606 putative GEF interaction site [polypeptide binding]; other site 657317005607 GTP/Mg2+ binding site [chemical binding]; other site 657317005608 Switch I region; other site 657317005609 G2 box; other site 657317005610 G3 box; other site 657317005611 Switch II region; other site 657317005612 G4 box; other site 657317005613 G5 box; other site 657317005614 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 657317005615 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 657317005616 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 657317005617 YacP-like NYN domain; Region: NYN_YacP; pfam05991 657317005618 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 657317005619 methionine aminopeptidase; Provisional; Region: PRK12318 657317005620 SEC-C motif; Region: SEC-C; pfam02810 657317005621 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 657317005622 active site 657317005623 Yqey-like protein; Region: YqeY; cl17540 657317005624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 657317005625 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657317005626 NlpC/P60 family; Region: NLPC_P60; pfam00877 657317005627 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 657317005628 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 657317005629 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657317005630 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 657317005631 PrcB C-terminal; Region: PrcB_C; pfam14343 657317005632 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 657317005633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 657317005634 putative acyl-acceptor binding pocket; other site 657317005635 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 657317005636 Ca binding site [ion binding]; other site 657317005637 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 657317005638 active site 657317005639 catalytic site [active] 657317005640 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317005641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317005642 dimer interface [polypeptide binding]; other site 657317005643 conserved gate region; other site 657317005644 putative PBP binding loops; other site 657317005645 ABC-ATPase subunit interface; other site 657317005646 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 657317005647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317005648 dimer interface [polypeptide binding]; other site 657317005649 conserved gate region; other site 657317005650 putative PBP binding loops; other site 657317005651 ABC-ATPase subunit interface; other site 657317005652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317005653 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 657317005654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317005655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317005656 DNA binding site [nucleotide binding] 657317005657 domain linker motif; other site 657317005658 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317005659 dimerization interface [polypeptide binding]; other site 657317005660 ligand binding site [chemical binding]; other site 657317005661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657317005662 active site 657317005663 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 657317005664 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 657317005665 Ligand Binding Site [chemical binding]; other site 657317005666 TilS substrate C-terminal domain; Region: TilS_C; smart00977 657317005667 stage II sporulation protein E; Region: spore_II_E; TIGR02865 657317005668 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 657317005669 Septum formation initiator; Region: DivIC; cl17659 657317005670 YabP family; Region: YabP; cl06766 657317005671 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317005672 RNA binding surface [nucleotide binding]; other site 657317005673 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 657317005674 IHF dimer interface [polypeptide binding]; other site 657317005675 IHF - DNA interface [nucleotide binding]; other site 657317005676 PEGA domain; Region: PEGA; pfam08308 657317005677 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 657317005678 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 657317005679 active site 657317005680 NTP binding site [chemical binding]; other site 657317005681 metal binding triad [ion binding]; metal-binding site 657317005682 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 657317005683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317005684 Zn2+ binding site [ion binding]; other site 657317005685 Mg2+ binding site [ion binding]; other site 657317005686 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 657317005687 prolyl-tRNA synthetase; Provisional; Region: PRK08661 657317005688 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 657317005689 dimer interface [polypeptide binding]; other site 657317005690 motif 1; other site 657317005691 active site 657317005692 motif 2; other site 657317005693 motif 3; other site 657317005694 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 657317005695 anticodon binding site; other site 657317005696 zinc-binding site [ion binding]; other site 657317005697 glycerate kinase; Region: TIGR00045 657317005698 AzlC protein; Region: AzlC; cl00570 657317005699 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 657317005700 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317005701 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317005702 metal binding site [ion binding]; metal-binding site 657317005703 active site 657317005704 I-site; other site 657317005705 Hemerythrin; Region: Hemerythrin; cd12107 657317005706 Fe binding site [ion binding]; other site 657317005707 Predicted transcriptional regulators [Transcription]; Region: COG1725 657317005708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317005709 DNA-binding site [nucleotide binding]; DNA binding site 657317005710 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 657317005711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317005712 active site 657317005713 I-site; other site 657317005714 metal binding site [ion binding]; metal-binding site 657317005715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 657317005716 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 657317005717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317005718 dimerization interface [polypeptide binding]; other site 657317005719 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657317005720 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317005721 dimer interface [polypeptide binding]; other site 657317005722 putative CheW interface [polypeptide binding]; other site 657317005723 Predicted permeases [General function prediction only]; Region: COG0730 657317005724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 657317005725 MarR family; Region: MarR_2; pfam12802 657317005726 MarR family; Region: MarR_2; cl17246 657317005727 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 657317005728 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317005729 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 657317005730 AAA domain; Region: AAA_14; pfam13173 657317005731 Nuclease-related domain; Region: NERD; pfam08378 657317005732 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 657317005733 active site 657317005734 putative catalytic site [active] 657317005735 DNA binding site [nucleotide binding] 657317005736 putative phosphate binding site [ion binding]; other site 657317005737 metal binding site A [ion binding]; metal-binding site 657317005738 AP binding site [nucleotide binding]; other site 657317005739 metal binding site B [ion binding]; metal-binding site 657317005740 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 657317005741 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 657317005742 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 657317005743 trimer interface [polypeptide binding]; other site 657317005744 active site 657317005745 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 657317005746 catalytic site [active] 657317005747 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 657317005748 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 657317005749 putative active site [active] 657317005750 putative catalytic site [active] 657317005751 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317005752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317005753 dimer interface [polypeptide binding]; other site 657317005754 conserved gate region; other site 657317005755 putative PBP binding loops; other site 657317005756 ABC-ATPase subunit interface; other site 657317005757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317005758 dimer interface [polypeptide binding]; other site 657317005759 conserved gate region; other site 657317005760 putative PBP binding loops; other site 657317005761 ABC-ATPase subunit interface; other site 657317005762 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317005763 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317005764 DNA binding site [nucleotide binding] 657317005765 domain linker motif; other site 657317005766 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 657317005767 dimerization interface [polypeptide binding]; other site 657317005768 ligand binding site [chemical binding]; other site 657317005769 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317005770 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 657317005771 Vacuolar ATP synthase subunit S1 (ATP6S1); Region: ATP-synt_S1; pfam05827 657317005772 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 657317005773 metal ion-dependent adhesion site (MIDAS); other site 657317005774 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 657317005775 putative active site [active] 657317005776 AAA domain; Region: AAA_22; pfam13401 657317005777 AAA domain; Region: AAA_14; pfam13173 657317005778 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 657317005779 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657317005780 active site 657317005781 catalytic site [active] 657317005782 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 657317005783 Melibiase; Region: Melibiase; pfam02065 657317005784 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657317005785 active site 657317005786 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317005787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317005788 dimer interface [polypeptide binding]; other site 657317005789 conserved gate region; other site 657317005790 putative PBP binding loops; other site 657317005791 ABC-ATPase subunit interface; other site 657317005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317005793 dimer interface [polypeptide binding]; other site 657317005794 conserved gate region; other site 657317005795 putative PBP binding loops; other site 657317005796 ABC-ATPase subunit interface; other site 657317005797 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317005798 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 657317005799 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317005800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317005801 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317005802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317005803 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 657317005804 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 657317005805 ligand binding site [chemical binding]; other site 657317005806 calcium binding site [ion binding]; other site 657317005807 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 657317005808 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 657317005809 ligand binding site [chemical binding]; other site 657317005810 Cache domain; Region: Cache_1; pfam02743 657317005811 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 657317005812 Histidine kinase; Region: His_kinase; pfam06580 657317005813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317005814 ATP binding site [chemical binding]; other site 657317005815 Mg2+ binding site [ion binding]; other site 657317005816 G-X-G motif; other site 657317005817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317005818 active site 657317005819 phosphorylation site [posttranslational modification] 657317005820 intermolecular recognition site; other site 657317005821 dimerization interface [polypeptide binding]; other site 657317005822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 657317005823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317005824 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 657317005825 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 657317005826 TM-ABC transporter signature motif; other site 657317005827 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 657317005828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317005829 Walker A/P-loop; other site 657317005830 ATP binding site [chemical binding]; other site 657317005831 Q-loop/lid; other site 657317005832 ABC transporter signature motif; other site 657317005833 Walker B; other site 657317005834 D-loop; other site 657317005835 H-loop/switch region; other site 657317005836 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 657317005837 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657317005838 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657317005839 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657317005840 active site 657317005841 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 657317005842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317005843 FeS/SAM binding site; other site 657317005844 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 657317005845 Pyruvate formate lyase 1; Region: PFL1; cd01678 657317005846 coenzyme A binding site [chemical binding]; other site 657317005847 active site 657317005848 catalytic residues [active] 657317005849 glycine loop; other site 657317005850 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 657317005851 MraW methylase family; Region: Methyltransf_5; cl17771 657317005852 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317005853 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 657317005854 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317005855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317005856 dimerization interface [polypeptide binding]; other site 657317005857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317005858 dimer interface [polypeptide binding]; other site 657317005859 phosphorylation site [posttranslational modification] 657317005860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317005861 ATP binding site [chemical binding]; other site 657317005862 Mg2+ binding site [ion binding]; other site 657317005863 G-X-G motif; other site 657317005864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317005865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317005866 active site 657317005867 phosphorylation site [posttranslational modification] 657317005868 intermolecular recognition site; other site 657317005869 dimerization interface [polypeptide binding]; other site 657317005870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317005871 DNA binding site [nucleotide binding] 657317005872 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 657317005873 S-adenosylmethionine synthetase; Validated; Region: PRK05250 657317005874 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 657317005875 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 657317005876 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317005877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317005878 Zn2+ binding site [ion binding]; other site 657317005879 Mg2+ binding site [ion binding]; other site 657317005880 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 657317005881 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 657317005882 hinge; other site 657317005883 active site 657317005884 shikimate kinase; Reviewed; Region: aroK; PRK00131 657317005885 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 657317005886 ADP binding site [chemical binding]; other site 657317005887 magnesium binding site [ion binding]; other site 657317005888 putative shikimate binding site; other site 657317005889 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 657317005890 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 657317005891 putative active site [active] 657317005892 catalytic residue [active] 657317005893 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 657317005894 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 657317005895 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 657317005896 minor groove reading motif; other site 657317005897 helix-hairpin-helix signature motif; other site 657317005898 active site 657317005899 regulatory protein SpoVG; Reviewed; Region: PRK13259 657317005900 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 657317005901 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657317005902 ligand binding site; other site 657317005903 oligomer interface; other site 657317005904 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657317005905 dimer interface [polypeptide binding]; other site 657317005906 N-terminal domain interface [polypeptide binding]; other site 657317005907 sulfate 1 binding site; other site 657317005908 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 657317005909 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657317005910 ligand binding site; other site 657317005911 oligomer interface; other site 657317005912 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657317005913 dimer interface [polypeptide binding]; other site 657317005914 N-terminal domain interface [polypeptide binding]; other site 657317005915 sulfate 1 binding site; other site 657317005916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 657317005917 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 657317005918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657317005919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657317005920 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 657317005921 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 657317005922 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 657317005923 DNA replication protein DnaC; Validated; Region: PRK06835 657317005924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317005925 Walker A motif; other site 657317005926 ATP binding site [chemical binding]; other site 657317005927 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 657317005928 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 657317005929 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657317005930 active site 657317005931 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 657317005932 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 657317005933 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 657317005934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317005935 RNA binding surface [nucleotide binding]; other site 657317005936 30S ribosomal protein S11; Validated; Region: PRK05309 657317005937 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 657317005938 30S ribosomal protein S13; Region: bact_S13; TIGR03631 657317005939 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 657317005940 rRNA binding site [nucleotide binding]; other site 657317005941 predicted 30S ribosome binding site; other site 657317005942 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 657317005943 active site 657317005944 adenylate kinase; Reviewed; Region: adk; PRK00279 657317005945 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 657317005946 AMP-binding site [chemical binding]; other site 657317005947 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 657317005948 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 657317005949 SecY translocase; Region: SecY; pfam00344 657317005950 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 657317005951 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 657317005952 23S rRNA binding site [nucleotide binding]; other site 657317005953 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 657317005954 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 657317005955 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 657317005956 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 657317005957 5S rRNA interface [nucleotide binding]; other site 657317005958 L27 interface [polypeptide binding]; other site 657317005959 23S rRNA interface [nucleotide binding]; other site 657317005960 L5 interface [polypeptide binding]; other site 657317005961 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 657317005962 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 657317005963 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 657317005964 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 657317005965 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 657317005966 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 657317005967 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 657317005968 RNA binding site [nucleotide binding]; other site 657317005969 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 657317005970 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 657317005971 23S rRNA interface [nucleotide binding]; other site 657317005972 putative translocon interaction site; other site 657317005973 signal recognition particle (SRP54) interaction site; other site 657317005974 L23 interface [polypeptide binding]; other site 657317005975 trigger factor interaction site; other site 657317005976 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 657317005977 23S rRNA interface [nucleotide binding]; other site 657317005978 5S rRNA interface [nucleotide binding]; other site 657317005979 putative antibiotic binding site [chemical binding]; other site 657317005980 L25 interface [polypeptide binding]; other site 657317005981 L27 interface [polypeptide binding]; other site 657317005982 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 657317005983 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 657317005984 G-X-X-G motif; other site 657317005985 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 657317005986 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 657317005987 protein-rRNA interface [nucleotide binding]; other site 657317005988 putative translocon binding site; other site 657317005989 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 657317005990 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 657317005991 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 657317005992 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 657317005993 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 657317005994 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 657317005995 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 657317005996 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 657317005997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 657317005998 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 657317005999 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 657317006000 Cl binding site [ion binding]; other site 657317006001 oligomer interface [polypeptide binding]; other site 657317006002 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 657317006003 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 657317006004 active site 657317006005 HIGH motif; other site 657317006006 dimer interface [polypeptide binding]; other site 657317006007 KMSKS motif; other site 657317006008 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 657317006009 putative deacylase active site [active] 657317006010 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 657317006011 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 657317006012 active site 657317006013 catalytic site [active] 657317006014 metal binding site [ion binding]; metal-binding site 657317006015 dimer interface [polypeptide binding]; other site 657317006016 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 657317006017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657317006018 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 657317006019 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 657317006020 trimer interface [polypeptide binding]; other site 657317006021 putative metal binding site [ion binding]; other site 657317006022 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 657317006023 two-component sensor protein; Provisional; Region: cpxA; PRK09470 657317006024 HAMP domain; Region: HAMP; pfam00672 657317006025 dimerization interface [polypeptide binding]; other site 657317006026 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 657317006027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317006028 dimer interface [polypeptide binding]; other site 657317006029 putative CheW interface [polypeptide binding]; other site 657317006030 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 657317006031 SnoaL-like domain; Region: SnoaL_2; pfam12680 657317006032 H+ Antiporter protein; Region: 2A0121; TIGR00900 657317006033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 657317006034 putative substrate translocation pore; other site 657317006035 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 657317006036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317006037 FeS/SAM binding site; other site 657317006038 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 657317006039 elongation factor Tu; Reviewed; Region: PRK00049 657317006040 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 657317006041 G1 box; other site 657317006042 GEF interaction site [polypeptide binding]; other site 657317006043 GTP/Mg2+ binding site [chemical binding]; other site 657317006044 Switch I region; other site 657317006045 G2 box; other site 657317006046 G3 box; other site 657317006047 Switch II region; other site 657317006048 G4 box; other site 657317006049 G5 box; other site 657317006050 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 657317006051 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 657317006052 Antibiotic Binding Site [chemical binding]; other site 657317006053 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 657317006054 S17 interaction site [polypeptide binding]; other site 657317006055 S8 interaction site; other site 657317006056 16S rRNA interaction site [nucleotide binding]; other site 657317006057 streptomycin interaction site [chemical binding]; other site 657317006058 23S rRNA interaction site [nucleotide binding]; other site 657317006059 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 657317006060 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 657317006061 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 657317006062 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 657317006063 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 657317006064 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 657317006065 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 657317006066 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 657317006067 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 657317006068 G-loop; other site 657317006069 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 657317006070 DNA binding site [nucleotide binding] 657317006071 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 657317006072 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 657317006073 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 657317006074 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 657317006075 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 657317006076 RPB1 interaction site [polypeptide binding]; other site 657317006077 RPB10 interaction site [polypeptide binding]; other site 657317006078 RPB11 interaction site [polypeptide binding]; other site 657317006079 RPB3 interaction site [polypeptide binding]; other site 657317006080 RPB12 interaction site [polypeptide binding]; other site 657317006081 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 657317006082 core dimer interface [polypeptide binding]; other site 657317006083 peripheral dimer interface [polypeptide binding]; other site 657317006084 L10 interface [polypeptide binding]; other site 657317006085 L11 interface [polypeptide binding]; other site 657317006086 putative EF-Tu interaction site [polypeptide binding]; other site 657317006087 putative EF-G interaction site [polypeptide binding]; other site 657317006088 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 657317006089 mRNA/rRNA interface [nucleotide binding]; other site 657317006090 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 657317006091 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 657317006092 23S rRNA interface [nucleotide binding]; other site 657317006093 L7/L12 interface [polypeptide binding]; other site 657317006094 putative thiostrepton binding site; other site 657317006095 L25 interface [polypeptide binding]; other site 657317006096 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 657317006097 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 657317006098 putative homodimer interface [polypeptide binding]; other site 657317006099 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 657317006100 heterodimer interface [polypeptide binding]; other site 657317006101 homodimer interface [polypeptide binding]; other site 657317006102 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 657317006103 flagellar capping protein; Validated; Region: fliD; PRK07737 657317006104 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 657317006105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317006106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317006107 active site 657317006108 phosphorylation site [posttranslational modification] 657317006109 intermolecular recognition site; other site 657317006110 dimerization interface [polypeptide binding]; other site 657317006111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317006112 DNA binding site [nucleotide binding] 657317006113 FtsX-like permease family; Region: FtsX; pfam02687 657317006114 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 657317006115 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317006116 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 657317006117 Walker A/P-loop; other site 657317006118 ATP binding site [chemical binding]; other site 657317006119 Q-loop/lid; other site 657317006120 ABC transporter signature motif; other site 657317006121 Walker B; other site 657317006122 D-loop; other site 657317006123 H-loop/switch region; other site 657317006124 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317006125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 657317006126 dimerization interface [polypeptide binding]; other site 657317006127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317006128 DNA binding site [nucleotide binding] 657317006129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317006130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317006131 active site 657317006132 phosphorylation site [posttranslational modification] 657317006133 intermolecular recognition site; other site 657317006134 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 657317006135 AAA domain; Region: AAA_14; pfam13173 657317006136 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657317006137 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 657317006138 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 657317006139 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 657317006140 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 657317006141 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 657317006142 dimerization domain swap beta strand [polypeptide binding]; other site 657317006143 regulatory protein interface [polypeptide binding]; other site 657317006144 active site 657317006145 regulatory phosphorylation site [posttranslational modification]; other site 657317006146 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 657317006147 PRD domain; Region: PRD; pfam00874 657317006148 PRD domain; Region: PRD; pfam00874 657317006149 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 657317006150 active site 657317006151 P-loop; other site 657317006152 phosphorylation site [posttranslational modification] 657317006153 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 657317006154 active site 657317006155 phosphorylation site [posttranslational modification] 657317006156 DHH family; Region: DHH; pfam01368 657317006157 phosphoglycolate phosphatase; Provisional; Region: PRK13222 657317006158 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317006159 motif II; other site 657317006160 Sulfatase; Region: Sulfatase; cl17466 657317006161 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 657317006162 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 657317006163 putative ligand binding site [chemical binding]; other site 657317006164 putative NAD binding site [chemical binding]; other site 657317006165 catalytic site [active] 657317006166 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 657317006167 active site 657317006168 catalytic residues [active] 657317006169 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 657317006170 active site 657317006171 substrate binding site [chemical binding]; other site 657317006172 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 657317006173 FMN binding site [chemical binding]; other site 657317006174 putative catalytic residues [active] 657317006175 Predicted permeases [General function prediction only]; Region: COG0679 657317006176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 657317006177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317006178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317006179 ABC transporter; Region: ABC_tran_2; pfam12848 657317006180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 657317006181 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 657317006182 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 657317006183 dimer interface [polypeptide binding]; other site 657317006184 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 657317006185 FMN binding site [chemical binding]; other site 657317006186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317006187 non-specific DNA binding site [nucleotide binding]; other site 657317006188 salt bridge; other site 657317006189 sequence-specific DNA binding site [nucleotide binding]; other site 657317006190 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 657317006191 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 657317006192 MFS/sugar transport protein; Region: MFS_2; pfam13347 657317006193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657317006194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 657317006195 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 657317006196 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 657317006197 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 657317006198 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317006199 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657317006200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317006201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317006202 DNA binding site [nucleotide binding] 657317006203 domain linker motif; other site 657317006204 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 657317006205 Ligand Binding Site [chemical binding]; other site 657317006206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317006207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317006208 metal binding site [ion binding]; metal-binding site 657317006209 active site 657317006210 I-site; other site 657317006211 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 657317006212 putative active site [active] 657317006213 dimerization interface [polypeptide binding]; other site 657317006214 putative tRNAtyr binding site [nucleotide binding]; other site 657317006215 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 657317006216 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 657317006217 dinuclear metal binding motif [ion binding]; other site 657317006218 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 657317006219 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 657317006220 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 657317006221 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317006222 active site 657317006223 Int/Topo IB signature motif; other site 657317006224 DNA binding site [nucleotide binding] 657317006225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 657317006226 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 657317006227 putative acyl-acceptor binding pocket; other site 657317006228 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 657317006229 LexA repressor; Validated; Region: PRK00215 657317006230 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 657317006231 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 657317006232 Catalytic site [active] 657317006233 Oligomerisation domain; Region: Oligomerisation; pfam02410 657317006234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317006235 Zn2+ binding site [ion binding]; other site 657317006236 Mg2+ binding site [ion binding]; other site 657317006237 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 657317006238 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 657317006239 active site 657317006240 (T/H)XGH motif; other site 657317006241 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 657317006242 GTPase CgtA; Reviewed; Region: obgE; PRK12297 657317006243 GTP1/OBG; Region: GTP1_OBG; pfam01018 657317006244 Obg GTPase; Region: Obg; cd01898 657317006245 G1 box; other site 657317006246 GTP/Mg2+ binding site [chemical binding]; other site 657317006247 Switch I region; other site 657317006248 G2 box; other site 657317006249 G3 box; other site 657317006250 Switch II region; other site 657317006251 G4 box; other site 657317006252 G5 box; other site 657317006253 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 657317006254 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 657317006255 Protein of unknown function (DUF464); Region: DUF464; pfam04327 657317006256 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 657317006257 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 657317006258 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 657317006259 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 657317006260 homodimer interface [polypeptide binding]; other site 657317006261 oligonucleotide binding site [chemical binding]; other site 657317006262 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 657317006263 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 657317006264 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 657317006265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317006266 FeS/SAM binding site; other site 657317006267 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 657317006268 putative active site pocket [active] 657317006269 4-fold oligomerization interface [polypeptide binding]; other site 657317006270 metal binding residues [ion binding]; metal-binding site 657317006271 3-fold/trimer interface [polypeptide binding]; other site 657317006272 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 657317006273 histidinol dehydrogenase; Region: hisD; TIGR00069 657317006274 NAD binding site [chemical binding]; other site 657317006275 dimerization interface [polypeptide binding]; other site 657317006276 product binding site; other site 657317006277 substrate binding site [chemical binding]; other site 657317006278 zinc binding site [ion binding]; other site 657317006279 catalytic residues [active] 657317006280 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 657317006281 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 657317006282 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 657317006283 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 657317006284 dimer interface [polypeptide binding]; other site 657317006285 motif 1; other site 657317006286 active site 657317006287 motif 2; other site 657317006288 motif 3; other site 657317006289 Recombination protein U; Region: RecU; cl01314 657317006290 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657317006291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317006292 RNA binding surface [nucleotide binding]; other site 657317006293 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657317006294 active site 657317006295 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 657317006296 hypothetical protein; Provisional; Region: PRK00955 657317006297 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 657317006298 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 657317006299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317006300 RNA binding surface [nucleotide binding]; other site 657317006301 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 657317006302 active site 657317006303 uracil binding [chemical binding]; other site 657317006304 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 657317006305 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 657317006306 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 657317006307 active site 657317006308 (T/H)XGH motif; other site 657317006309 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 657317006310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317006311 S-adenosylmethionine binding site [chemical binding]; other site 657317006312 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 657317006313 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 657317006314 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657317006315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317006316 FeS/SAM binding site; other site 657317006317 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 657317006318 Guanylate kinase; Region: Guanylate_kin; pfam00625 657317006319 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 657317006320 catalytic site [active] 657317006321 hypothetical protein; Provisional; Region: PRK11820 657317006322 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 657317006323 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 657317006324 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 657317006325 Domain of unknown function (DUF814); Region: DUF814; pfam05670 657317006326 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 657317006327 Y-family of DNA polymerases; Region: PolY; cl12025 657317006328 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 657317006329 ssDNA binding site; other site 657317006330 generic binding surface II; other site 657317006331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317006332 ATP binding site [chemical binding]; other site 657317006333 putative Mg++ binding site [ion binding]; other site 657317006334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 657317006335 nucleotide binding region [chemical binding]; other site 657317006336 ATP-binding site [chemical binding]; other site 657317006337 Asp23 family; Region: Asp23; pfam03780 657317006338 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 657317006339 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; pfam09579 657317006340 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 657317006341 active site 657317006342 Ap6A binding site [chemical binding]; other site 657317006343 nudix motif; other site 657317006344 metal binding site [ion binding]; metal-binding site 657317006345 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 657317006346 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657317006347 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 657317006348 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 657317006349 Peptidase family U32; Region: Peptidase_U32; pfam01136 657317006350 Collagenase; Region: DUF3656; pfam12392 657317006351 Cell division protein ZapA; Region: ZapA; pfam05164 657317006352 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 657317006353 RuvA N terminal domain; Region: RuvA_N; pfam01330 657317006354 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 657317006355 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 657317006356 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 657317006357 trimer interface [polypeptide binding]; other site 657317006358 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 657317006359 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657317006360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317006361 FeS/SAM binding site; other site 657317006362 TRAM domain; Region: TRAM; cl01282 657317006363 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 657317006364 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 657317006365 putative catalytic cysteine [active] 657317006366 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 657317006367 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 657317006368 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 657317006369 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 657317006370 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 657317006371 nucleotide binding site [chemical binding]; other site 657317006372 homotetrameric interface [polypeptide binding]; other site 657317006373 putative phosphate binding site [ion binding]; other site 657317006374 putative allosteric binding site; other site 657317006375 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 657317006376 ApbE family; Region: ApbE; pfam02424 657317006377 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 657317006378 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 657317006379 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 657317006380 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 657317006381 electron transport complex RsxE subunit; Provisional; Region: PRK12405 657317006382 FMN-binding domain; Region: FMN_bind; cl01081 657317006383 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 657317006384 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 657317006385 SLBB domain; Region: SLBB; pfam10531 657317006386 4Fe-4S binding domain; Region: Fer4_6; pfam12837 657317006387 RNase_H superfamily; Region: RNase_H_2; pfam13482 657317006388 active site 657317006389 catalytic site [active] 657317006390 substrate binding site [chemical binding]; other site 657317006391 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 657317006392 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 657317006393 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 657317006394 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 657317006395 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 657317006396 RNA binding site [nucleotide binding]; other site 657317006397 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 657317006398 RNA binding site [nucleotide binding]; other site 657317006399 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 657317006400 RNA binding site [nucleotide binding]; other site 657317006401 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 657317006402 RNA binding site [nucleotide binding]; other site 657317006403 LytB protein; Region: LYTB; cl00507 657317006404 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 657317006405 cytidylate kinase; Provisional; Region: cmk; PRK00023 657317006406 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 657317006407 CMP-binding site; other site 657317006408 The sites determining sugar specificity; other site 657317006409 flavoprotein, HI0933 family; Region: TIGR00275 657317006410 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657317006411 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657317006412 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657317006413 putative active site [active] 657317006414 oxaloacetate decarboxylase; Provisional; Region: PRK12331 657317006415 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 657317006416 active site 657317006417 catalytic residues [active] 657317006418 metal binding site [ion binding]; metal-binding site 657317006419 homodimer binding site [polypeptide binding]; other site 657317006420 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 657317006421 carboxyltransferase (CT) interaction site; other site 657317006422 biotinylation site [posttranslational modification]; other site 657317006423 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 657317006424 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 657317006425 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 657317006426 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657317006427 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 657317006428 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 657317006429 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 657317006430 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 657317006431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317006432 FeS/SAM binding site; other site 657317006433 HemN C-terminal domain; Region: HemN_C; pfam06969 657317006434 GTP-binding protein LepA; Provisional; Region: PRK05433 657317006435 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 657317006436 G1 box; other site 657317006437 putative GEF interaction site [polypeptide binding]; other site 657317006438 GTP/Mg2+ binding site [chemical binding]; other site 657317006439 Switch I region; other site 657317006440 G2 box; other site 657317006441 G3 box; other site 657317006442 Switch II region; other site 657317006443 G4 box; other site 657317006444 G5 box; other site 657317006445 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 657317006446 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 657317006447 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 657317006448 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 657317006449 stage II sporulation protein P; Region: spore_II_P; TIGR02867 657317006450 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 657317006451 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 657317006452 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 657317006453 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 657317006454 Competence protein; Region: Competence; pfam03772 657317006455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317006456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317006457 dimer interface [polypeptide binding]; other site 657317006458 phosphorylation site [posttranslational modification] 657317006459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317006460 ATP binding site [chemical binding]; other site 657317006461 Mg2+ binding site [ion binding]; other site 657317006462 G-X-G motif; other site 657317006463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317006464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317006465 active site 657317006466 phosphorylation site [posttranslational modification] 657317006467 intermolecular recognition site; other site 657317006468 dimerization interface [polypeptide binding]; other site 657317006469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317006470 DNA binding site [nucleotide binding] 657317006471 SLBB domain; Region: SLBB; pfam10531 657317006472 comEA protein; Region: comE; TIGR01259 657317006473 Helix-hairpin-helix motif; Region: HHH; pfam00633 657317006474 acetylornithine aminotransferase; Provisional; Region: PRK02627 657317006475 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 657317006476 inhibitor-cofactor binding pocket; inhibition site 657317006477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317006478 catalytic residue [active] 657317006479 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 657317006480 feedback inhibition sensing region; other site 657317006481 homohexameric interface [polypeptide binding]; other site 657317006482 nucleotide binding site [chemical binding]; other site 657317006483 N-acetyl-L-glutamate binding site [chemical binding]; other site 657317006484 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 657317006485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 657317006486 Coenzyme A binding pocket [chemical binding]; other site 657317006487 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 657317006488 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 657317006489 argininosuccinate synthase; Provisional; Region: PRK13820 657317006490 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 657317006491 ANP binding site [chemical binding]; other site 657317006492 Substrate Binding Site II [chemical binding]; other site 657317006493 Substrate Binding Site I [chemical binding]; other site 657317006494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 657317006495 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 657317006496 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 657317006497 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657317006498 active site 657317006499 HIGH motif; other site 657317006500 nucleotide binding site [chemical binding]; other site 657317006501 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657317006502 active site 657317006503 KMSKS motif; other site 657317006504 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 657317006505 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 657317006506 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 657317006507 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317006508 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317006509 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 657317006510 MFS/sugar transport protein; Region: MFS_2; pfam13347 657317006511 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 657317006512 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 657317006513 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 657317006514 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 657317006515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 657317006516 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 657317006517 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657317006518 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657317006519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317006520 RNA binding surface [nucleotide binding]; other site 657317006521 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657317006522 active site 657317006523 lipoprotein signal peptidase; Provisional; Region: PRK14767 657317006524 lipoprotein signal peptidase; Provisional; Region: PRK14787 657317006525 Protein of unknown function (DUF552); Region: DUF552; pfam04472 657317006526 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 657317006527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657317006528 catalytic residue [active] 657317006529 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 657317006530 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 657317006531 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 657317006532 active site 657317006533 dimer interfaces [polypeptide binding]; other site 657317006534 catalytic residues [active] 657317006535 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 657317006536 Septum formation topological specificity factor MinE; Region: MinE; cl00538 657317006537 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 657317006538 rod shape-determining protein MreC; Provisional; Region: PRK13922 657317006539 rod shape-determining protein MreC; Region: MreC; pfam04085 657317006540 rod shape-determining protein MreB; Provisional; Region: PRK13927 657317006541 MreB and similar proteins; Region: MreB_like; cd10225 657317006542 nucleotide binding site [chemical binding]; other site 657317006543 Mg binding site [ion binding]; other site 657317006544 putative protofilament interaction site [polypeptide binding]; other site 657317006545 RodZ interaction site [polypeptide binding]; other site 657317006546 hypothetical protein; Reviewed; Region: PRK00024 657317006547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 657317006548 helix-hairpin-helix signature motif; other site 657317006549 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 657317006550 MPN+ (JAMM) motif; other site 657317006551 Zinc-binding site [ion binding]; other site 657317006552 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 657317006553 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 657317006554 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 657317006555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317006556 ATP binding site [chemical binding]; other site 657317006557 Mg2+ binding site [ion binding]; other site 657317006558 G-X-G motif; other site 657317006559 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 657317006560 ATP binding site [chemical binding]; other site 657317006561 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 657317006562 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 657317006563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657317006564 flavoprotein, HI0933 family; Region: TIGR00275 657317006565 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 657317006566 stage V sporulation protein B; Region: spore_V_B; TIGR02900 657317006567 metal-binding heat shock protein; Provisional; Region: PRK00016 657317006568 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 657317006569 PhoH-like protein; Region: PhoH; pfam02562 657317006570 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 657317006571 YabP family; Region: YabP; cl06766 657317006572 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 657317006573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 657317006574 active site 657317006575 GcpE protein; Region: GcpE; pfam04551 657317006576 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 657317006577 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 657317006578 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 657317006579 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 657317006580 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 657317006581 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 657317006582 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 657317006583 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 657317006584 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 657317006585 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 657317006586 catalytic residue [active] 657317006587 putative FPP diphosphate binding site; other site 657317006588 putative FPP binding hydrophobic cleft; other site 657317006589 dimer interface [polypeptide binding]; other site 657317006590 putative IPP diphosphate binding site; other site 657317006591 ribosome recycling factor; Reviewed; Region: frr; PRK00083 657317006592 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 657317006593 hinge region; other site 657317006594 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 657317006595 putative nucleotide binding site [chemical binding]; other site 657317006596 uridine monophosphate binding site [chemical binding]; other site 657317006597 homohexameric interface [polypeptide binding]; other site 657317006598 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 657317006599 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 657317006600 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 657317006601 NodB motif; other site 657317006602 active site 657317006603 catalytic site [active] 657317006604 Zn binding site [ion binding]; other site 657317006605 translation elongation factor Ts; Region: tsf; TIGR00116 657317006606 UBA/TS-N domain; Region: UBA; pfam00627 657317006607 Elongation factor TS; Region: EF_TS; pfam00889 657317006608 Elongation factor TS; Region: EF_TS; pfam00889 657317006609 Elongation factor TS; Region: EF_TS; pfam00889 657317006610 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 657317006611 rRNA interaction site [nucleotide binding]; other site 657317006612 S8 interaction site; other site 657317006613 putative laminin-1 binding site; other site 657317006614 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 657317006615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317006616 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657317006617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317006618 DNA binding residues [nucleotide binding] 657317006619 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 657317006620 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 657317006621 CheC-like family; Region: CheC; pfam04509 657317006622 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 657317006623 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 657317006624 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 657317006625 putative binding surface; other site 657317006626 active site 657317006627 P2 response regulator binding domain; Region: P2; pfam07194 657317006628 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 657317006629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317006630 ATP binding site [chemical binding]; other site 657317006631 Mg2+ binding site [ion binding]; other site 657317006632 G-X-G motif; other site 657317006633 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 657317006634 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 657317006635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317006636 active site 657317006637 phosphorylation site [posttranslational modification] 657317006638 intermolecular recognition site; other site 657317006639 dimerization interface [polypeptide binding]; other site 657317006640 CheB methylesterase; Region: CheB_methylest; pfam01339 657317006641 Flagellar protein YcgR; Region: YcgR_2; pfam12945 657317006642 PilZ domain; Region: PilZ; pfam07238 657317006643 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 657317006644 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 657317006645 P-loop; other site 657317006646 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 657317006647 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317006648 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 657317006649 FHIPEP family; Region: FHIPEP; pfam00771 657317006650 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 657317006651 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 657317006652 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 657317006653 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 657317006654 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 657317006655 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 657317006656 CheC-like family; Region: CheC; pfam04509 657317006657 CheC-like family; Region: CheC; pfam04509 657317006658 flagellar motor switch protein FliN; Region: fliN; TIGR02480 657317006659 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 657317006660 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 657317006661 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 657317006662 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657317006663 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657317006664 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 657317006665 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 657317006666 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 657317006667 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 657317006668 Uncharacterized conserved protein [Function unknown]; Region: COG3334 657317006669 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 657317006670 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 657317006671 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 657317006672 MgtE intracellular N domain; Region: MgtE_N; cl15244 657317006673 FliG C-terminal domain; Region: FliG_C; pfam01706 657317006674 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 657317006675 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 657317006676 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 657317006677 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 657317006678 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 657317006679 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657317006680 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 657317006681 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 657317006682 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 657317006683 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 657317006684 transcriptional repressor CodY; Validated; Region: PRK04158 657317006685 CodY GAF-like domain; Region: CodY; pfam06018 657317006686 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 657317006687 DNA topoisomerase I; Validated; Region: PRK05582 657317006688 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 657317006689 active site 657317006690 interdomain interaction site; other site 657317006691 putative metal-binding site [ion binding]; other site 657317006692 nucleotide binding site [chemical binding]; other site 657317006693 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 657317006694 domain I; other site 657317006695 DNA binding groove [nucleotide binding] 657317006696 phosphate binding site [ion binding]; other site 657317006697 domain II; other site 657317006698 domain III; other site 657317006699 nucleotide binding site [chemical binding]; other site 657317006700 catalytic site [active] 657317006701 domain IV; other site 657317006702 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657317006703 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 657317006704 DNA protecting protein DprA; Region: dprA; TIGR00732 657317006705 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 657317006706 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 657317006707 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 657317006708 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 657317006709 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 657317006710 sporulation sigma factor SigG; Reviewed; Region: PRK08215 657317006711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317006712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317006713 DNA binding residues [nucleotide binding] 657317006714 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 657317006715 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 657317006716 active site 657317006717 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 657317006718 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 657317006719 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 657317006720 active site 657317006721 catalytic site [active] 657317006722 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 657317006723 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 657317006724 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 657317006725 Part of AAA domain; Region: AAA_19; pfam13245 657317006726 Family description; Region: UvrD_C_2; pfam13538 657317006727 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 657317006728 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 657317006729 active site 657317006730 HIGH motif; other site 657317006731 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 657317006732 active site 657317006733 KMSKS motif; other site 657317006734 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 657317006735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317006736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317006737 homodimer interface [polypeptide binding]; other site 657317006738 catalytic residue [active] 657317006739 putative oxidoreductase; Provisional; Region: PRK12831 657317006740 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 657317006741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657317006742 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 657317006743 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 657317006744 FAD binding pocket [chemical binding]; other site 657317006745 FAD binding motif [chemical binding]; other site 657317006746 phosphate binding motif [ion binding]; other site 657317006747 beta-alpha-beta structure motif; other site 657317006748 NAD binding pocket [chemical binding]; other site 657317006749 Iron coordination center [ion binding]; other site 657317006750 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317006751 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 657317006752 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 657317006753 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 657317006754 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 657317006755 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 657317006756 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 657317006757 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657317006758 HAMP domain; Region: HAMP; pfam00672 657317006759 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317006760 dimer interface [polypeptide binding]; other site 657317006761 putative CheW interface [polypeptide binding]; other site 657317006762 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 657317006763 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 657317006764 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 657317006765 motif 1; other site 657317006766 active site 657317006767 motif 2; other site 657317006768 motif 3; other site 657317006769 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 657317006770 DHHA1 domain; Region: DHHA1; pfam02272 657317006771 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 657317006772 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 657317006773 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 657317006774 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 657317006775 4-alpha-glucanotransferase; Provisional; Region: PRK14508 657317006776 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 657317006777 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 657317006778 Cl- selectivity filter; other site 657317006779 Cl- binding residues [ion binding]; other site 657317006780 pore gating glutamate residue; other site 657317006781 dimer interface [polypeptide binding]; other site 657317006782 pullulanase, type I; Region: pulA_typeI; TIGR02104 657317006783 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 657317006784 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 657317006785 Ca binding site [ion binding]; other site 657317006786 active site 657317006787 catalytic site [active] 657317006788 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 657317006789 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 657317006790 classical (c) SDRs; Region: SDR_c; cd05233 657317006791 NAD(P) binding site [chemical binding]; other site 657317006792 active site 657317006793 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 657317006794 active site 657317006795 catalytic site [active] 657317006796 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657317006797 Catalytic site [active] 657317006798 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 657317006799 DNA binding site [nucleotide binding] 657317006800 Bacterial transcriptional activator domain; Region: BTAD; smart01043 657317006801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657317006802 binding surface 657317006803 TPR motif; other site 657317006804 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317006805 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 657317006806 metal binding site [ion binding]; metal-binding site 657317006807 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 657317006808 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 657317006809 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 657317006810 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 657317006811 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 657317006812 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 657317006813 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 657317006814 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 657317006815 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 657317006816 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 657317006817 ribonuclease R; Region: RNase_R; TIGR02063 657317006818 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 657317006819 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657317006820 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 657317006821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 657317006822 dimer interface [polypeptide binding]; other site 657317006823 putative CheW interface [polypeptide binding]; other site 657317006824 PilZ domain; Region: PilZ; pfam07238 657317006825 pyruvate phosphate dikinase; Provisional; Region: PRK09279 657317006826 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 657317006827 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 657317006828 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 657317006829 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 657317006830 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 657317006831 active site 657317006832 catalytic site [active] 657317006833 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 657317006834 Cna protein B-type domain; Region: Cna_B; pfam05738 657317006835 Collagen binding domain; Region: Collagen_bind; pfam05737 657317006836 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 657317006837 domain interaction interfaces [polypeptide binding]; other site 657317006838 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 657317006839 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657317006840 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657317006841 Catalytic site [active] 657317006842 glycyl-tRNA synthetase; Provisional; Region: PRK04173 657317006843 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 657317006844 motif 1; other site 657317006845 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 657317006846 active site 657317006847 motif 2; other site 657317006848 motif 3; other site 657317006849 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 657317006850 anticodon binding site; other site 657317006851 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 657317006852 Recombination protein O N terminal; Region: RecO_N; pfam11967 657317006853 Recombination protein O C terminal; Region: RecO_C; pfam02565 657317006854 GTPase Era; Reviewed; Region: era; PRK00089 657317006855 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 657317006856 G1 box; other site 657317006857 GTP/Mg2+ binding site [chemical binding]; other site 657317006858 Switch I region; other site 657317006859 G2 box; other site 657317006860 Switch II region; other site 657317006861 G3 box; other site 657317006862 G4 box; other site 657317006863 G5 box; other site 657317006864 KH domain; Region: KH_2; pfam07650 657317006865 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 657317006866 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 657317006867 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 657317006868 Peptidase M16C associated; Region: M16C_assoc; pfam08367 657317006869 Mechanosensitive ion channel; Region: MS_channel; pfam00924 657317006870 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 657317006871 putative ligand binding site [chemical binding]; other site 657317006872 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 657317006873 putative NAD binding site [chemical binding]; other site 657317006874 putative catalytic site [active] 657317006875 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 657317006876 L-serine binding site [chemical binding]; other site 657317006877 ACT domain interface; other site 657317006878 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 657317006879 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 657317006880 PYR/PP interface [polypeptide binding]; other site 657317006881 dimer interface [polypeptide binding]; other site 657317006882 TPP binding site [chemical binding]; other site 657317006883 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 657317006884 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 657317006885 TPP-binding site [chemical binding]; other site 657317006886 dimer interface [polypeptide binding]; other site 657317006887 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 657317006888 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 657317006889 tartrate dehydrogenase; Region: TTC; TIGR02089 657317006890 Preprotein translocase subunit; Region: YajC; pfam02699 657317006891 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 657317006892 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 657317006893 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 657317006894 homodimer interface [polypeptide binding]; other site 657317006895 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 657317006896 active site 657317006897 homodimer interface [polypeptide binding]; other site 657317006898 catalytic site [active] 657317006899 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 657317006900 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 657317006901 Tetramer interface [polypeptide binding]; other site 657317006902 active site 657317006903 FMN-binding site [chemical binding]; other site 657317006904 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657317006905 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 657317006906 Walker A/P-loop; other site 657317006907 ATP binding site [chemical binding]; other site 657317006908 Q-loop/lid; other site 657317006909 ABC transporter signature motif; other site 657317006910 Walker B; other site 657317006911 D-loop; other site 657317006912 H-loop/switch region; other site 657317006913 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317006914 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 657317006915 Accessory gene regulator B; Region: AgrB; cl01873 657317006916 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317006917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317006918 active site 657317006919 phosphorylation site [posttranslational modification] 657317006920 intermolecular recognition site; other site 657317006921 LytTr DNA-binding domain; Region: LytTR; pfam04397 657317006922 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 657317006923 Peptidase family U32; Region: Peptidase_U32; pfam01136 657317006924 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 657317006925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317006926 S-adenosylmethionine binding site [chemical binding]; other site 657317006927 YceG-like family; Region: YceG; pfam02618 657317006928 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 657317006929 hypothetical protein; Provisional; Region: PRK05473 657317006930 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 657317006931 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 657317006932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317006933 FeS/SAM binding site; other site 657317006934 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 657317006935 regulatory protein interface [polypeptide binding]; other site 657317006936 regulatory phosphorylation site [posttranslational modification]; other site 657317006937 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 657317006938 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 657317006939 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 657317006940 Ligand Binding Site [chemical binding]; other site 657317006941 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 657317006942 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 657317006943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 657317006944 catalytic residue [active] 657317006945 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 657317006946 RNA methyltransferase, RsmE family; Region: TIGR00046 657317006947 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 657317006948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317006949 S-adenosylmethionine binding site [chemical binding]; other site 657317006950 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 657317006951 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 657317006952 HSP70 interaction site [polypeptide binding]; other site 657317006953 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 657317006954 substrate binding site [polypeptide binding]; other site 657317006955 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 657317006956 Zn binding sites [ion binding]; other site 657317006957 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 657317006958 dimer interface [polypeptide binding]; other site 657317006959 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 657317006960 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 657317006961 nucleotide binding site [chemical binding]; other site 657317006962 NEF interaction site [polypeptide binding]; other site 657317006963 SBD interface [polypeptide binding]; other site 657317006964 GrpE; Region: GrpE; pfam01025 657317006965 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 657317006966 dimer interface [polypeptide binding]; other site 657317006967 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 657317006968 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 657317006969 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 657317006970 RelB antitoxin; Region: RelB; cl01171 657317006971 Cysteine-rich small domain; Region: zf-like; cl00946 657317006972 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 657317006973 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317006974 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 657317006975 catalytic triad [active] 657317006976 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 657317006977 active site 657317006978 SAM binding site [chemical binding]; other site 657317006979 homodimer interface [polypeptide binding]; other site 657317006980 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 657317006981 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 657317006982 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 657317006983 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 657317006984 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 657317006985 active site 657317006986 SAM binding site [chemical binding]; other site 657317006987 homodimer interface [polypeptide binding]; other site 657317006988 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 657317006989 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 657317006990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 657317006991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317006992 homodimer interface [polypeptide binding]; other site 657317006993 catalytic residue [active] 657317006994 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 657317006995 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 657317006996 catalytic core [active] 657317006997 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 657317006998 cobalamin synthase; Reviewed; Region: cobS; PRK00235 657317006999 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 657317007000 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 657317007001 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 657317007002 putative dimer interface [polypeptide binding]; other site 657317007003 active site pocket [active] 657317007004 putative cataytic base [active] 657317007005 cobyric acid synthase; Provisional; Region: PRK00784 657317007006 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 657317007007 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 657317007008 catalytic triad [active] 657317007009 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 657317007010 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 657317007011 Walker A/P-loop; other site 657317007012 ATP binding site [chemical binding]; other site 657317007013 Q-loop/lid; other site 657317007014 ABC transporter signature motif; other site 657317007015 Walker B; other site 657317007016 D-loop; other site 657317007017 H-loop/switch region; other site 657317007018 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 657317007019 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 657317007020 ABC-ATPase subunit interface; other site 657317007021 dimer interface [polypeptide binding]; other site 657317007022 putative PBP binding regions; other site 657317007023 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 657317007024 intersubunit interface [polypeptide binding]; other site 657317007025 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 657317007026 heme-binding site [chemical binding]; other site 657317007027 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 657317007028 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 657317007029 active site 657317007030 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 657317007031 active site 657317007032 N-terminal domain interface [polypeptide binding]; other site 657317007033 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 657317007034 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 657317007035 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 657317007036 putative active site [active] 657317007037 catalytic site [active] 657317007038 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 657317007039 putative active site [active] 657317007040 catalytic site [active] 657317007041 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 657317007042 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 657317007043 RNase E interface [polypeptide binding]; other site 657317007044 trimer interface [polypeptide binding]; other site 657317007045 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 657317007046 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 657317007047 RNase E interface [polypeptide binding]; other site 657317007048 trimer interface [polypeptide binding]; other site 657317007049 active site 657317007050 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 657317007051 putative nucleic acid binding region [nucleotide binding]; other site 657317007052 G-X-X-G motif; other site 657317007053 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 657317007054 RNA binding site [nucleotide binding]; other site 657317007055 domain interface; other site 657317007056 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 657317007057 16S/18S rRNA binding site [nucleotide binding]; other site 657317007058 S13e-L30e interaction site [polypeptide binding]; other site 657317007059 25S rRNA binding site [nucleotide binding]; other site 657317007060 Bacterial SH3 domain; Region: SH3_3; pfam08239 657317007061 Bacterial SH3 domain; Region: SH3_3; pfam08239 657317007062 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657317007063 NlpC/P60 family; Region: NLPC_P60; pfam00877 657317007064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 657317007065 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 657317007066 active site 657317007067 Riboflavin kinase; Region: Flavokinase; pfam01687 657317007068 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 657317007069 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 657317007070 RNA binding site [nucleotide binding]; other site 657317007071 active site 657317007072 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 657317007073 DHH family; Region: DHH; pfam01368 657317007074 DHHA1 domain; Region: DHHA1; pfam02272 657317007075 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 657317007076 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 657317007077 translation initiation factor IF-2; Region: IF-2; TIGR00487 657317007078 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 657317007079 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 657317007080 G1 box; other site 657317007081 putative GEF interaction site [polypeptide binding]; other site 657317007082 GTP/Mg2+ binding site [chemical binding]; other site 657317007083 Switch I region; other site 657317007084 G2 box; other site 657317007085 G3 box; other site 657317007086 Switch II region; other site 657317007087 G4 box; other site 657317007088 G5 box; other site 657317007089 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 657317007090 Translation-initiation factor 2; Region: IF-2; pfam11987 657317007091 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 657317007092 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 657317007093 putative RNA binding cleft [nucleotide binding]; other site 657317007094 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 657317007095 NusA N-terminal domain; Region: NusA_N; pfam08529 657317007096 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 657317007097 RNA binding site [nucleotide binding]; other site 657317007098 homodimer interface [polypeptide binding]; other site 657317007099 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 657317007100 G-X-X-G motif; other site 657317007101 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 657317007102 G-X-X-G motif; other site 657317007103 ribosome maturation protein RimP; Reviewed; Region: PRK00092 657317007104 Sm and related proteins; Region: Sm_like; cl00259 657317007105 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 657317007106 putative oligomer interface [polypeptide binding]; other site 657317007107 putative RNA binding site [nucleotide binding]; other site 657317007108 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 657317007109 UDP-glucose 4-epimerase; Region: PLN02240 657317007110 NAD binding site [chemical binding]; other site 657317007111 homodimer interface [polypeptide binding]; other site 657317007112 active site 657317007113 substrate binding site [chemical binding]; other site 657317007114 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317007115 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657317007116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317007117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317007118 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 657317007119 23S rRNA binding site [nucleotide binding]; other site 657317007120 L21 binding site [polypeptide binding]; other site 657317007121 L13 binding site [polypeptide binding]; other site 657317007122 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 657317007123 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 657317007124 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 657317007125 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 657317007126 Cna protein B-type domain; Region: Cna_B; pfam05738 657317007127 Fic/DOC family; Region: Fic; pfam02661 657317007128 Fumarase C-terminus; Region: Fumerase_C; cl00795 657317007129 fumarate hydratase; Provisional; Region: PRK06246 657317007130 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 657317007131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317007132 Mg2+ binding site [ion binding]; other site 657317007133 G-X-G motif; other site 657317007134 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 657317007135 anchoring element; other site 657317007136 dimer interface [polypeptide binding]; other site 657317007137 ATP binding site [chemical binding]; other site 657317007138 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 657317007139 active site 657317007140 putative metal-binding site [ion binding]; other site 657317007141 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 657317007142 recombination protein F; Reviewed; Region: recF; PRK00064 657317007143 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 657317007144 Walker A/P-loop; other site 657317007145 ATP binding site [chemical binding]; other site 657317007146 Q-loop/lid; other site 657317007147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317007148 ABC transporter signature motif; other site 657317007149 Walker B; other site 657317007150 D-loop; other site 657317007151 H-loop/switch region; other site 657317007152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317007153 RNA binding surface [nucleotide binding]; other site 657317007154 DNA polymerase III subunit beta; Validated; Region: PRK05643 657317007155 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 657317007156 putative DNA binding surface [nucleotide binding]; other site 657317007157 dimer interface [polypeptide binding]; other site 657317007158 beta-clamp/clamp loader binding surface; other site 657317007159 beta-clamp/translesion DNA polymerase binding surface; other site 657317007160 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 657317007161 DnaA N-terminal domain; Region: DnaA_N; pfam11638 657317007162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317007163 Walker A motif; other site 657317007164 ATP binding site [chemical binding]; other site 657317007165 Walker B motif; other site 657317007166 arginine finger; other site 657317007167 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 657317007168 DnaA box-binding interface [nucleotide binding]; other site 657317007169 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 657317007170 ribonuclease P; Reviewed; Region: rnpA; PRK00499 657317007171 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 657317007172 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 657317007173 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 657317007174 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 657317007175 trmE is a tRNA modification GTPase; Region: trmE; cd04164 657317007176 G1 box; other site 657317007177 GTP/Mg2+ binding site [chemical binding]; other site 657317007178 Switch I region; other site 657317007179 G2 box; other site 657317007180 Switch II region; other site 657317007181 G3 box; other site 657317007182 G4 box; other site 657317007183 G5 box; other site 657317007184 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 657317007185 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 657317007186 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 657317007187 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 657317007188 YolD-like protein; Region: YolD; pfam08863 657317007189 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 657317007190 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 657317007191 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 657317007192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 657317007193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 657317007194 Histidine kinase; Region: HisKA_3; pfam07730 657317007195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317007196 ATP binding site [chemical binding]; other site 657317007197 Mg2+ binding site [ion binding]; other site 657317007198 G-X-G motif; other site 657317007199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 657317007200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317007201 active site 657317007202 phosphorylation site [posttranslational modification] 657317007203 intermolecular recognition site; other site 657317007204 dimerization interface [polypeptide binding]; other site 657317007205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 657317007206 DNA binding residues [nucleotide binding] 657317007207 dimerization interface [polypeptide binding]; other site 657317007208 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 657317007209 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 657317007210 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 657317007211 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657317007212 P-loop; other site 657317007213 Magnesium ion binding site [ion binding]; other site 657317007214 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657317007215 Magnesium ion binding site [ion binding]; other site 657317007216 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 657317007217 ParB-like nuclease domain; Region: ParB; smart00470 657317007218 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317007219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317007220 Zn2+ binding site [ion binding]; other site 657317007221 Mg2+ binding site [ion binding]; other site 657317007222 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 657317007223 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 657317007224 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 657317007225 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 657317007226 putative active site [active] 657317007227 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 657317007228 active site 657317007229 P-loop; other site 657317007230 phosphorylation site [posttranslational modification] 657317007231 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 657317007232 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 657317007233 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 657317007234 active site 657317007235 methionine cluster; other site 657317007236 phosphorylation site [posttranslational modification] 657317007237 metal binding site [ion binding]; metal-binding site 657317007238 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 657317007239 beta-galactosidase; Region: BGL; TIGR03356 657317007240 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317007241 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 657317007242 Transcriptional regulators [Transcription]; Region: PurR; COG1609 657317007243 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 657317007244 DNA binding site [nucleotide binding] 657317007245 domain linker motif; other site 657317007246 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 657317007247 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 657317007248 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 657317007249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317007250 dimer interface [polypeptide binding]; other site 657317007251 conserved gate region; other site 657317007252 putative PBP binding loops; other site 657317007253 ABC-ATPase subunit interface; other site 657317007254 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 657317007255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317007256 dimer interface [polypeptide binding]; other site 657317007257 conserved gate region; other site 657317007258 putative PBP binding loops; other site 657317007259 ABC-ATPase subunit interface; other site 657317007260 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 657317007261 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 657317007262 Ca binding site [ion binding]; other site 657317007263 active site 657317007264 catalytic site [active] 657317007265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317007266 salt bridge; other site 657317007267 non-specific DNA binding site [nucleotide binding]; other site 657317007268 sequence-specific DNA binding site [nucleotide binding]; other site 657317007269 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 657317007270 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 657317007271 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 657317007272 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 657317007273 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 657317007274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 657317007275 FeS/SAM binding site; other site 657317007276 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 657317007277 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 657317007278 hypothetical protein; Reviewed; Region: PRK12497 657317007279 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 657317007280 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 657317007281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317007282 DNA-binding site [nucleotide binding]; DNA binding site 657317007283 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 657317007284 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317007285 Walker A/P-loop; other site 657317007286 ATP binding site [chemical binding]; other site 657317007287 Q-loop/lid; other site 657317007288 ABC transporter signature motif; other site 657317007289 Walker B; other site 657317007290 D-loop; other site 657317007291 H-loop/switch region; other site 657317007292 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657317007293 GTP-binding protein Der; Reviewed; Region: PRK00093 657317007294 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 657317007295 G1 box; other site 657317007296 GTP/Mg2+ binding site [chemical binding]; other site 657317007297 Switch I region; other site 657317007298 G2 box; other site 657317007299 Switch II region; other site 657317007300 G3 box; other site 657317007301 G4 box; other site 657317007302 G5 box; other site 657317007303 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 657317007304 G1 box; other site 657317007305 GTP/Mg2+ binding site [chemical binding]; other site 657317007306 Switch I region; other site 657317007307 G2 box; other site 657317007308 G3 box; other site 657317007309 Switch II region; other site 657317007310 G4 box; other site 657317007311 G5 box; other site 657317007312 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 657317007313 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 657317007314 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 657317007315 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 657317007316 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 657317007317 trimer interface [polypeptide binding]; other site 657317007318 active site 657317007319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 657317007320 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 657317007321 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 657317007322 Walker A/P-loop; other site 657317007323 ATP binding site [chemical binding]; other site 657317007324 Q-loop/lid; other site 657317007325 ABC transporter signature motif; other site 657317007326 Walker B; other site 657317007327 D-loop; other site 657317007328 H-loop/switch region; other site 657317007329 TOBE domain; Region: TOBE_2; pfam08402 657317007330 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 657317007331 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 657317007332 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 657317007333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317007334 Mg2+ binding site [ion binding]; other site 657317007335 G-X-G motif; other site 657317007336 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 657317007337 anchoring element; other site 657317007338 dimer interface [polypeptide binding]; other site 657317007339 ATP binding site [chemical binding]; other site 657317007340 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 657317007341 active site 657317007342 putative metal-binding site [ion binding]; other site 657317007343 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 657317007344 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 657317007345 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 657317007346 CAP-like domain; other site 657317007347 active site 657317007348 primary dimer interface [polypeptide binding]; other site 657317007349 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 657317007350 metal ion-dependent adhesion site (MIDAS); other site 657317007351 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 657317007352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317007353 motif II; other site 657317007354 CAAX protease self-immunity; Region: Abi; pfam02517 657317007355 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 657317007356 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 657317007357 active site 657317007358 dimer interface [polypeptide binding]; other site 657317007359 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 657317007360 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 657317007361 active site 657317007362 FMN binding site [chemical binding]; other site 657317007363 substrate binding site [chemical binding]; other site 657317007364 3Fe-4S cluster binding site [ion binding]; other site 657317007365 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 657317007366 domain interface; other site 657317007367 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 657317007368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 657317007369 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 657317007370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317007371 active site 657317007372 motif I; other site 657317007373 motif II; other site 657317007374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 657317007375 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 657317007376 oligomerisation interface [polypeptide binding]; other site 657317007377 mobile loop; other site 657317007378 roof hairpin; other site 657317007379 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 657317007380 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 657317007381 ring oligomerisation interface [polypeptide binding]; other site 657317007382 ATP/Mg binding site [chemical binding]; other site 657317007383 stacking interactions; other site 657317007384 hinge regions; other site 657317007385 EDD domain protein, DegV family; Region: DegV; TIGR00762 657317007386 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 657317007387 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 657317007388 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317007389 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 657317007390 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 657317007391 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 657317007392 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 657317007393 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 657317007394 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 657317007395 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 657317007396 hypothetical protein; Provisional; Region: PRK05590 657317007397 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 657317007398 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 657317007399 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 657317007400 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 657317007401 active site 657317007402 dimer interface [polypeptide binding]; other site 657317007403 motif 1; other site 657317007404 motif 2; other site 657317007405 motif 3; other site 657317007406 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 657317007407 anticodon binding site; other site 657317007408 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 657317007409 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 657317007410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 657317007411 MraZ protein; Region: MraZ; pfam02381 657317007412 MraZ protein; Region: MraZ; pfam02381 657317007413 MraW methylase family; Region: Methyltransf_5; pfam01795 657317007414 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 657317007415 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 657317007416 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 657317007417 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 657317007418 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 657317007419 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 657317007420 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 657317007421 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 657317007422 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 657317007423 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 657317007424 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 657317007425 Beta-Casp domain; Region: Beta-Casp; smart01027 657317007426 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 657317007427 VanZ like family; Region: VanZ; pfam04892 657317007428 QueT transporter; Region: QueT; pfam06177 657317007429 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317007430 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317007431 Zn2+ binding site [ion binding]; other site 657317007432 Mg2+ binding site [ion binding]; other site 657317007433 sporulation sigma factor SigG; Reviewed; Region: PRK08215 657317007434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317007435 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657317007436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317007437 DNA binding residues [nucleotide binding] 657317007438 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 657317007439 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 657317007440 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657317007441 active site 657317007442 HIGH motif; other site 657317007443 nucleotide binding site [chemical binding]; other site 657317007444 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 657317007445 KMSK motif region; other site 657317007446 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 657317007447 tRNA binding surface [nucleotide binding]; other site 657317007448 anticodon binding site; other site 657317007449 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 657317007450 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 657317007451 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 657317007452 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562 657317007453 recombinase A; Provisional; Region: recA; PRK09354 657317007454 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 657317007455 hexamer interface [polypeptide binding]; other site 657317007456 Walker A motif; other site 657317007457 ATP binding site [chemical binding]; other site 657317007458 Walker B motif; other site 657317007459 recombination regulator RecX; Reviewed; Region: recX; PRK00117 657317007460 phosphodiesterase; Provisional; Region: PRK12704 657317007461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317007462 Zn2+ binding site [ion binding]; other site 657317007463 Mg2+ binding site [ion binding]; other site 657317007464 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 657317007465 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 657317007466 putative active site [active] 657317007467 metal binding site [ion binding]; metal-binding site 657317007468 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 657317007469 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 657317007470 dimer interface [polypeptide binding]; other site 657317007471 ADP-ribose binding site [chemical binding]; other site 657317007472 active site 657317007473 nudix motif; other site 657317007474 metal binding site [ion binding]; metal-binding site 657317007475 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 657317007476 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 657317007477 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 657317007478 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317007479 RNA binding surface [nucleotide binding]; other site 657317007480 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 657317007481 probable active site [active] 657317007482 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 657317007483 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 657317007484 nucleotide binding pocket [chemical binding]; other site 657317007485 K-X-D-G motif; other site 657317007486 catalytic site [active] 657317007487 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 657317007488 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 657317007489 Dimer interface [polypeptide binding]; other site 657317007490 Homoserine O-succinyltransferase; Region: HTS; pfam04204 657317007491 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 657317007492 proposed active site lysine [active] 657317007493 conserved cys residue [active] 657317007494 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 657317007495 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657317007496 ligand binding site; other site 657317007497 oligomer interface; other site 657317007498 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657317007499 dimer interface [polypeptide binding]; other site 657317007500 N-terminal domain interface [polypeptide binding]; other site 657317007501 sulfate 1 binding site; other site 657317007502 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 657317007503 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 657317007504 ligand binding site; other site 657317007505 oligomer interface; other site 657317007506 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 657317007507 dimer interface [polypeptide binding]; other site 657317007508 N-terminal domain interface [polypeptide binding]; other site 657317007509 sulfate 1 binding site; other site 657317007510 Asp23 family; Region: Asp23; pfam03780 657317007511 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 657317007512 putative RNA binding site [nucleotide binding]; other site 657317007513 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 657317007514 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 657317007515 generic binding surface II; other site 657317007516 generic binding surface I; other site 657317007517 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 657317007518 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 657317007519 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 657317007520 substrate binding pocket [chemical binding]; other site 657317007521 chain length determination region; other site 657317007522 substrate-Mg2+ binding site; other site 657317007523 catalytic residues [active] 657317007524 aspartate-rich region 1; other site 657317007525 active site lid residues [active] 657317007526 aspartate-rich region 2; other site 657317007527 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 657317007528 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 657317007529 TPP-binding site; other site 657317007530 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 657317007531 PYR/PP interface [polypeptide binding]; other site 657317007532 dimer interface [polypeptide binding]; other site 657317007533 TPP binding site [chemical binding]; other site 657317007534 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 657317007535 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 657317007536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 657317007537 RNA binding surface [nucleotide binding]; other site 657317007538 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 657317007539 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 657317007540 ATP-NAD kinase; Region: NAD_kinase; pfam01513 657317007541 arginine repressor; Provisional; Region: argR; PRK00441 657317007542 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 657317007543 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 657317007544 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 657317007545 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 657317007546 Walker A/P-loop; other site 657317007547 ATP binding site [chemical binding]; other site 657317007548 Q-loop/lid; other site 657317007549 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 657317007550 ABC transporter signature motif; other site 657317007551 Walker B; other site 657317007552 D-loop; other site 657317007553 H-loop/switch region; other site 657317007554 potassium/proton antiporter; Reviewed; Region: PRK05326 657317007555 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 657317007556 TrkA-C domain; Region: TrkA_C; pfam02080 657317007557 TrkA-C domain; Region: TrkA_C; pfam02080 657317007558 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 657317007559 protein binding site [polypeptide binding]; other site 657317007560 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 657317007561 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 657317007562 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 657317007563 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 657317007564 FAD binding site [chemical binding]; other site 657317007565 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 657317007566 Na2 binding site [ion binding]; other site 657317007567 putative substrate binding site 1 [chemical binding]; other site 657317007568 Na binding site 1 [ion binding]; other site 657317007569 putative substrate binding site 2 [chemical binding]; other site 657317007570 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 657317007571 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 657317007572 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 657317007573 Walker A motif; other site 657317007574 ATP binding site [chemical binding]; other site 657317007575 Walker B motif; other site 657317007576 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 657317007577 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317007578 Walker A motif; other site 657317007579 ATP binding site [chemical binding]; other site 657317007580 Walker B motif; other site 657317007581 Homeodomain-like domain; Region: HTH_23; cl17451 657317007582 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 657317007583 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 657317007584 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 657317007585 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 657317007586 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 657317007587 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 657317007588 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 657317007589 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317007590 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 657317007591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317007592 Walker A/P-loop; other site 657317007593 ATP binding site [chemical binding]; other site 657317007594 Q-loop/lid; other site 657317007595 ABC transporter signature motif; other site 657317007596 Walker B; other site 657317007597 D-loop; other site 657317007598 H-loop/switch region; other site 657317007599 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 657317007600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 657317007601 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 657317007602 Walker A/P-loop; other site 657317007603 ATP binding site [chemical binding]; other site 657317007604 Q-loop/lid; other site 657317007605 ABC transporter signature motif; other site 657317007606 Walker B; other site 657317007607 D-loop; other site 657317007608 H-loop/switch region; other site 657317007609 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 657317007610 glycogen synthase; Provisional; Region: glgA; PRK00654 657317007611 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 657317007612 ADP-binding pocket [chemical binding]; other site 657317007613 homodimer interface [polypeptide binding]; other site 657317007614 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 657317007615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317007616 dimer interface [polypeptide binding]; other site 657317007617 conserved gate region; other site 657317007618 putative PBP binding loops; other site 657317007619 ABC-ATPase subunit interface; other site 657317007620 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 657317007621 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 657317007622 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 657317007623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317007624 dimer interface [polypeptide binding]; other site 657317007625 conserved gate region; other site 657317007626 putative PBP binding loops; other site 657317007627 ABC-ATPase subunit interface; other site 657317007628 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 657317007629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317007630 Walker A/P-loop; other site 657317007631 ATP binding site [chemical binding]; other site 657317007632 Q-loop/lid; other site 657317007633 ABC transporter signature motif; other site 657317007634 Walker B; other site 657317007635 D-loop; other site 657317007636 H-loop/switch region; other site 657317007637 TOBE domain; Region: TOBE_2; pfam08402 657317007638 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 657317007639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317007640 non-specific DNA binding site [nucleotide binding]; other site 657317007641 salt bridge; other site 657317007642 sequence-specific DNA binding site [nucleotide binding]; other site 657317007643 Cupin domain; Region: Cupin_2; pfam07883 657317007644 Predicted transcriptional regulators [Transcription]; Region: COG1725 657317007645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317007646 DNA-binding site [nucleotide binding]; DNA binding site 657317007647 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 657317007648 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 657317007649 Walker A/P-loop; other site 657317007650 ATP binding site [chemical binding]; other site 657317007651 Q-loop/lid; other site 657317007652 ABC transporter signature motif; other site 657317007653 Walker B; other site 657317007654 D-loop; other site 657317007655 H-loop/switch region; other site 657317007656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317007657 Zn2+ binding site [ion binding]; other site 657317007658 Mg2+ binding site [ion binding]; other site 657317007659 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 657317007660 argininosuccinate lyase; Provisional; Region: PRK00855 657317007661 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 657317007662 active sites [active] 657317007663 tetramer interface [polypeptide binding]; other site 657317007664 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 657317007665 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 657317007666 Archaeal ATPase; Region: Arch_ATPase; pfam01637 657317007667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 657317007668 Walker A motif; other site 657317007669 ATP binding site [chemical binding]; other site 657317007670 Walker B motif; other site 657317007671 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 657317007672 DNA topoisomerase III; Provisional; Region: PRK07726 657317007673 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 657317007674 active site 657317007675 putative interdomain interaction site [polypeptide binding]; other site 657317007676 putative metal-binding site [ion binding]; other site 657317007677 putative nucleotide binding site [chemical binding]; other site 657317007678 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 657317007679 domain I; other site 657317007680 DNA binding groove [nucleotide binding] 657317007681 phosphate binding site [ion binding]; other site 657317007682 domain II; other site 657317007683 domain III; other site 657317007684 nucleotide binding site [chemical binding]; other site 657317007685 catalytic site [active] 657317007686 domain IV; other site 657317007687 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657317007688 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657317007689 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657317007690 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657317007691 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 657317007692 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 657317007693 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 657317007694 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 657317007695 GGGtGRT protein; Region: GGGtGRT; pfam14057 657317007696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 657317007697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317007698 active site 657317007699 phosphorylation site [posttranslational modification] 657317007700 intermolecular recognition site; other site 657317007701 dimerization interface [polypeptide binding]; other site 657317007702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 657317007703 DNA binding site [nucleotide binding] 657317007704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317007705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317007706 dimerization interface [polypeptide binding]; other site 657317007707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317007708 dimer interface [polypeptide binding]; other site 657317007709 phosphorylation site [posttranslational modification] 657317007710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317007711 ATP binding site [chemical binding]; other site 657317007712 Mg2+ binding site [ion binding]; other site 657317007713 G-X-G motif; other site 657317007714 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657317007715 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657317007716 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657317007717 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 657317007718 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317007719 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 657317007720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317007721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317007722 MFS/sugar transport protein; Region: MFS_2; pfam13347 657317007723 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 657317007724 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 657317007725 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 657317007726 catalytic residues [active] 657317007727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 657317007728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 657317007729 dimerization interface [polypeptide binding]; other site 657317007730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 657317007731 dimer interface [polypeptide binding]; other site 657317007732 phosphorylation site [posttranslational modification] 657317007733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 657317007734 ATP binding site [chemical binding]; other site 657317007735 Mg2+ binding site [ion binding]; other site 657317007736 G-X-G motif; other site 657317007737 Helix-turn-helix domain; Region: HTH_17; pfam12728 657317007738 Fic family protein [Function unknown]; Region: COG3177 657317007739 Fic/DOC family; Region: Fic; pfam02661 657317007740 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 657317007741 Helix-turn-helix domain; Region: HTH_18; pfam12833 657317007742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 657317007743 MFS/sugar transport protein; Region: MFS_2; pfam13347 657317007744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657317007745 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 657317007746 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 657317007747 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 657317007748 Abi-like protein; Region: Abi_2; pfam07751 657317007749 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 657317007750 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 657317007751 LytTr DNA-binding domain; Region: LytTR; smart00850 657317007752 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 657317007753 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 657317007754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 657317007755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 657317007756 metal binding site [ion binding]; metal-binding site 657317007757 active site 657317007758 I-site; other site 657317007759 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 657317007760 Predicted permeases [General function prediction only]; Region: COG0679 657317007761 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657317007762 membrane-bound complex binding site; other site 657317007763 hinge residues; other site 657317007764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 657317007765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 657317007766 substrate binding pocket [chemical binding]; other site 657317007767 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 657317007768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 657317007769 dimer interface [polypeptide binding]; other site 657317007770 conserved gate region; other site 657317007771 putative PBP binding loops; other site 657317007772 ABC-ATPase subunit interface; other site 657317007773 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 657317007774 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 657317007775 Walker A/P-loop; other site 657317007776 ATP binding site [chemical binding]; other site 657317007777 Q-loop/lid; other site 657317007778 ABC transporter signature motif; other site 657317007779 Walker B; other site 657317007780 D-loop; other site 657317007781 H-loop/switch region; other site 657317007782 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 657317007783 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 657317007784 active site 657317007785 substrate-binding site [chemical binding]; other site 657317007786 metal-binding site [ion binding] 657317007787 ATP binding site [chemical binding]; other site 657317007788 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 657317007789 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 657317007790 putative valine binding site [chemical binding]; other site 657317007791 dimer interface [polypeptide binding]; other site 657317007792 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 657317007793 ketol-acid reductoisomerase; Provisional; Region: PRK05479 657317007794 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 657317007795 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 657317007796 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 657317007797 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 657317007798 HIGH motif; other site 657317007799 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 657317007800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 657317007801 KMSKS motif; other site 657317007802 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 657317007803 tRNA binding surface [nucleotide binding]; other site 657317007804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 657317007805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 657317007806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 657317007807 dimerization interface [polypeptide binding]; other site 657317007808 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 657317007809 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 657317007810 substrate binding site [chemical binding]; other site 657317007811 ligand binding site [chemical binding]; other site 657317007812 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 657317007813 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 657317007814 substrate binding site [chemical binding]; other site 657317007815 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 657317007816 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 657317007817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 657317007818 catalytic residue [active] 657317007819 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 657317007820 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 657317007821 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 657317007822 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 657317007823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317007824 active site 657317007825 phosphorylation site [posttranslational modification] 657317007826 intermolecular recognition site; other site 657317007827 dimerization interface [polypeptide binding]; other site 657317007828 Stage II sporulation protein; Region: SpoIID; pfam08486 657317007829 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 657317007830 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 657317007831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 657317007832 S-adenosylmethionine binding site [chemical binding]; other site 657317007833 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 657317007834 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 657317007835 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 657317007836 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 657317007837 dimer interface [polypeptide binding]; other site 657317007838 motif 1; other site 657317007839 active site 657317007840 motif 2; other site 657317007841 motif 3; other site 657317007842 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 657317007843 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 657317007844 putative tRNA-binding site [nucleotide binding]; other site 657317007845 B3/4 domain; Region: B3_4; pfam03483 657317007846 tRNA synthetase B5 domain; Region: B5; smart00874 657317007847 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 657317007848 dimer interface [polypeptide binding]; other site 657317007849 motif 1; other site 657317007850 motif 3; other site 657317007851 motif 2; other site 657317007852 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 657317007853 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 657317007854 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 657317007855 PilZ domain; Region: PilZ; pfam07238 657317007856 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 657317007857 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 657317007858 hinge; other site 657317007859 active site 657317007860 prephenate dehydrogenase; Validated; Region: PRK06545 657317007861 prephenate dehydrogenase; Validated; Region: PRK08507 657317007862 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 657317007863 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 657317007864 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 657317007865 active site 657317007866 catalytic residues [active] 657317007867 metal binding site [ion binding]; metal-binding site 657317007868 Transcriptional regulators [Transcription]; Region: FadR; COG2186 657317007869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 657317007870 DNA-binding site [nucleotide binding]; DNA binding site 657317007871 FCD domain; Region: FCD; pfam07729 657317007872 isocitrate dehydrogenase; Validated; Region: PRK08299 657317007873 alanine racemase; Reviewed; Region: alr; PRK00053 657317007874 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 657317007875 active site 657317007876 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 657317007877 dimer interface [polypeptide binding]; other site 657317007878 substrate binding site [chemical binding]; other site 657317007879 catalytic residues [active] 657317007880 PemK-like protein; Region: PemK; pfam02452 657317007881 FOG: CBS domain [General function prediction only]; Region: COG0517 657317007882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 657317007883 Transporter associated domain; Region: CorC_HlyC; pfam03471 657317007884 hypothetical protein; Validated; Region: PRK00110 657317007885 glycogen synthase; Provisional; Region: glgA; PRK00654 657317007886 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 657317007887 ADP-binding pocket [chemical binding]; other site 657317007888 homodimer interface [polypeptide binding]; other site 657317007889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 657317007890 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 657317007891 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 657317007892 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 657317007893 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 657317007894 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 657317007895 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 657317007896 Potassium binding sites [ion binding]; other site 657317007897 Cesium cation binding sites [ion binding]; other site 657317007898 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 657317007899 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 657317007900 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 657317007901 homodimer interface [polypeptide binding]; other site 657317007902 NADP binding site [chemical binding]; other site 657317007903 substrate binding site [chemical binding]; other site 657317007904 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 657317007905 TPR repeat; Region: TPR_11; pfam13414 657317007906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 657317007907 binding surface 657317007908 TPR motif; other site 657317007909 Tetratricopeptide repeat; Region: TPR_16; pfam13432 657317007910 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 657317007911 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 657317007912 Chorismate mutase type II; Region: CM_2; pfam01817 657317007913 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 657317007914 Prephenate dehydratase; Region: PDT; pfam00800 657317007915 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 657317007916 putative L-Phe binding site [chemical binding]; other site 657317007917 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 657317007918 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317007919 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 657317007920 ParB-like nuclease domain; Region: ParBc; pfam02195 657317007921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 657317007922 non-specific DNA binding site [nucleotide binding]; other site 657317007923 salt bridge; other site 657317007924 sequence-specific DNA binding site [nucleotide binding]; other site 657317007925 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 657317007926 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 657317007927 Ligand Binding Site [chemical binding]; other site 657317007928 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 657317007929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 657317007930 Walker A/P-loop; other site 657317007931 Q-loop/lid; other site 657317007932 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007933 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007934 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007935 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007936 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007937 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007938 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007939 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 657317007940 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 657317007941 active site 657317007942 NTP binding site [chemical binding]; other site 657317007943 metal binding triad [ion binding]; metal-binding site 657317007944 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 657317007945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317007946 Zn2+ binding site [ion binding]; other site 657317007947 Mg2+ binding site [ion binding]; other site 657317007948 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 657317007949 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 657317007950 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 657317007951 Catalytic site [active] 657317007952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 657317007953 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 657317007954 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 657317007955 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317007956 Walker A motif; other site 657317007957 ATP binding site [chemical binding]; other site 657317007958 Walker B motif; other site 657317007959 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 657317007960 active site 657317007961 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 657317007962 metal binding site [ion binding]; metal-binding site 657317007963 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 657317007964 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 657317007965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317007966 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 657317007967 Walker A motif; other site 657317007968 ATP binding site [chemical binding]; other site 657317007969 Walker B motif; other site 657317007970 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 657317007971 active site 657317007972 Fe-S cluster binding site [ion binding]; other site 657317007973 Plant organelle RNA recognition domain; Region: PORR; pfam11955 657317007974 RRXRR protein; Region: RRXRR; pfam14239 657317007975 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 657317007976 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 657317007977 active site 657317007978 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 657317007979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 657317007980 binding surface 657317007981 TPR motif; other site 657317007982 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 657317007983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 657317007984 Zn2+ binding site [ion binding]; other site 657317007985 Mg2+ binding site [ion binding]; other site 657317007986 Probable transposase; Region: OrfB_IS605; pfam01385 657317007987 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 657317007988 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 657317007989 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 657317007990 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 657317007991 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 657317007992 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 657317007993 NAD-dependent deacetylase; Provisional; Region: PRK00481 657317007994 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 657317007995 NAD+ binding site [chemical binding]; other site 657317007996 substrate binding site [chemical binding]; other site 657317007997 Zn binding site [ion binding]; other site 657317007998 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317007999 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008000 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008001 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 657317008002 TIGR02452 family protein; Region: TIGR02452 657317008003 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 657317008004 Thg1 C terminal domain; Region: Thg1C; pfam14413 657317008005 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 657317008006 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 657317008007 active site 657317008008 catalytic site [active] 657317008009 substrate binding site [chemical binding]; other site 657317008010 Domain of unknown function (DUF222); Region: DUF222; pfam02720 657317008011 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 657317008012 putative metal binding site [ion binding]; other site 657317008013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317008014 non-specific DNA binding site [nucleotide binding]; other site 657317008015 salt bridge; other site 657317008016 sequence-specific DNA binding site [nucleotide binding]; other site 657317008017 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 657317008018 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 657317008019 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 657317008020 CAAX protease self-immunity; Region: Abi; pfam02517 657317008021 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 657317008022 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657317008023 P-loop; other site 657317008024 Magnesium ion binding site [ion binding]; other site 657317008025 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 657317008026 Magnesium ion binding site [ion binding]; other site 657317008027 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 657317008028 Probable transposase; Region: OrfB_IS605; pfam01385 657317008029 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 657317008030 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 657317008031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 657317008032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317008033 non-specific DNA binding site [nucleotide binding]; other site 657317008034 salt bridge; other site 657317008035 sequence-specific DNA binding site [nucleotide binding]; other site 657317008036 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 657317008037 RRXRR protein; Region: RRXRR; pfam14239 657317008038 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 657317008039 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 657317008040 active site 657317008041 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 657317008042 Glycine rich protein; Region: Gly_rich; pfam12810 657317008043 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 657317008044 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 657317008045 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 657317008046 active site 657317008047 catalytic residues [active] 657317008048 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 657317008049 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008050 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 657317008051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 657317008052 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 657317008053 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317008054 DNA binding residues [nucleotide binding] 657317008055 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 657317008056 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317008057 Walker A motif; other site 657317008058 ATP binding site [chemical binding]; other site 657317008059 Walker B motif; other site 657317008060 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 657317008061 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 657317008062 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 657317008063 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 657317008064 DNA-binding site [nucleotide binding]; DNA binding site 657317008065 RNA-binding motif; other site 657317008066 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 657317008067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 657317008068 DNA binding residues [nucleotide binding] 657317008069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 657317008070 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 657317008071 Probable transposase; Region: OrfB_IS605; pfam01385 657317008072 Transposase IS200 like; Region: Y1_Tnp; pfam01797 657317008073 DNA topoisomerase III; Provisional; Region: PRK07726 657317008074 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 657317008075 active site 657317008076 putative interdomain interaction site [polypeptide binding]; other site 657317008077 putative metal-binding site [ion binding]; other site 657317008078 putative nucleotide binding site [chemical binding]; other site 657317008079 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 657317008080 domain I; other site 657317008081 DNA binding groove [nucleotide binding] 657317008082 phosphate binding site [ion binding]; other site 657317008083 domain II; other site 657317008084 domain III; other site 657317008085 nucleotide binding site [chemical binding]; other site 657317008086 catalytic site [active] 657317008087 domain IV; other site 657317008088 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 657317008089 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 657317008090 active site 657317008091 Part of AAA domain; Region: AAA_19; pfam13245 657317008092 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 657317008093 Family description; Region: UvrD_C_2; pfam13538 657317008094 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 657317008095 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 657317008096 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657317008097 active site 657317008098 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 657317008100 non-specific DNA binding site [nucleotide binding]; other site 657317008101 salt bridge; other site 657317008102 sequence-specific DNA binding site [nucleotide binding]; other site 657317008103 Fic family protein [Function unknown]; Region: COG3177 657317008104 Fic/DOC family; Region: Fic; pfam02661 657317008105 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 657317008106 nad+ binding pocket [chemical binding]; other site 657317008107 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 657317008108 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 657317008109 active site 657317008110 catalytic site [active] 657317008111 substrate binding site [chemical binding]; other site 657317008112 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 657317008113 Mg binding site [ion binding]; other site 657317008114 nucleotide binding site [chemical binding]; other site 657317008115 putative protofilament interface [polypeptide binding]; other site 657317008116 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 657317008117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317008118 ATP binding site [chemical binding]; other site 657317008119 putative Mg++ binding site [ion binding]; other site 657317008120 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 657317008121 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 657317008122 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 657317008123 AAA domain; Region: AAA_30; pfam13604 657317008124 Family description; Region: UvrD_C_2; pfam13538 657317008125 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 657317008126 CHC2 zinc finger; Region: zf-CHC2; cl17510 657317008127 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 657317008128 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657317008129 active site 657317008130 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 657317008131 chaperone protein DnaJ; Provisional; Region: PRK14295 657317008132 stage V sporulation protein K; Region: spore_V_K; TIGR02881 657317008133 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 657317008134 Walker A motif; other site 657317008135 ATP binding site [chemical binding]; other site 657317008136 Walker B motif; other site 657317008137 arginine finger; other site 657317008138 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 657317008139 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 657317008140 putative active site [active] 657317008141 PhoH-like protein; Region: PhoH; pfam02562 657317008142 plasmid segregation protein ParM; Provisional; Region: PRK13917 657317008143 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 657317008144 Mg binding site [ion binding]; other site 657317008145 nucleotide binding site [chemical binding]; other site 657317008146 putative protofilament interface [polypeptide binding]; other site 657317008147 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 657317008148 IHF - DNA interface [nucleotide binding]; other site 657317008149 IHF dimer interface [polypeptide binding]; other site 657317008150 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317008151 Walker A motif; other site 657317008152 ATP binding site [chemical binding]; other site 657317008153 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 657317008154 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 657317008155 chloroplast Hsp70; Provisional; Region: PLN03184 657317008156 PrgI family protein; Region: PrgI; pfam12666 657317008157 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 657317008158 ATP cone domain; Region: ATP-cone; pfam03477 657317008159 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 657317008160 Response regulator receiver domain; Region: Response_reg; pfam00072 657317008161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 657317008162 active site 657317008163 phosphorylation site [posttranslational modification] 657317008164 intermolecular recognition site; other site 657317008165 dimerization interface [polypeptide binding]; other site 657317008166 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 657317008167 AAA-like domain; Region: AAA_10; pfam12846 657317008168 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 657317008169 thymidylate synthase; Reviewed; Region: thyA; PRK01827 657317008170 dimerization interface [polypeptide binding]; other site 657317008171 active site 657317008172 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 657317008173 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 657317008174 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 657317008175 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 657317008176 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 657317008177 putative active site [active] 657317008178 putative NTP binding site [chemical binding]; other site 657317008179 putative nucleic acid binding site [nucleotide binding]; other site 657317008180 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 657317008181 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 657317008182 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 657317008183 cofactor binding site; other site 657317008184 DNA binding site [nucleotide binding] 657317008185 substrate interaction site [chemical binding]; other site 657317008186 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 657317008187 DNA methylase; Region: N6_N4_Mtase; pfam01555 657317008188 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 657317008189 MPN+ (JAMM) motif; other site 657317008190 Zinc-binding site [ion binding]; other site 657317008191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 657317008192 Probable transposase; Region: OrfB_IS605; pfam01385 657317008193 NlpC/P60 family; Region: NLPC_P60; cl17555 657317008194 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 657317008195 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 657317008196 active site 657317008197 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 657317008198 putative ADP-ribose binding site [chemical binding]; other site 657317008199 putative active site [active] 657317008200 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 657317008201 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 657317008202 nucleotide binding pocket [chemical binding]; other site 657317008203 K-X-D-G motif; other site 657317008204 catalytic site [active] 657317008205 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 657317008206 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 657317008207 Dimer interface [polypeptide binding]; other site 657317008208 BRCT sequence motif; other site 657317008209 Bacterial PH domain; Region: DUF304; cl01348 657317008210 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 657317008211 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 657317008212 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 657317008213 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 657317008214 active site 657317008215 DNA binding site [nucleotide binding] 657317008216 Int/Topo IB signature motif; other site 657317008217 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 657317008218 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 657317008219 5'-3' exonuclease; Region: 53EXOc; smart00475 657317008220 active site 657317008221 metal binding site 1 [ion binding]; metal-binding site 657317008222 putative 5' ssDNA interaction site; other site 657317008223 metal binding site 3; metal-binding site 657317008224 metal binding site 2 [ion binding]; metal-binding site 657317008225 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 657317008226 putative DNA binding site [nucleotide binding]; other site 657317008227 putative metal binding site [ion binding]; other site 657317008228 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 657317008229 dimer interface [polypeptide binding]; other site 657317008230 ssDNA binding site [nucleotide binding]; other site 657317008231 tetramer (dimer of dimers) interface [polypeptide binding]; other site 657317008232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 657317008233 Transposase; Region: DDE_Tnp_ISL3; pfam01610 657317008234 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 657317008235 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 657317008236 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 657317008237 DHH family; Region: DHH; pfam01368 657317008238 DHHA1 domain; Region: DHHA1; pfam02272 657317008239 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 657317008240 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008241 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008242 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008243 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008244 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008245 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008246 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008247 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 657317008248 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008249 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008250 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 657317008251 AAA domain; Region: AAA_22; pfam13401 657317008252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 657317008253 ATP binding site [chemical binding]; other site 657317008254 putative Mg++ binding site [ion binding]; other site 657317008255 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 657317008256 SPFH domain / Band 7 family; Region: Band_7; pfam01145 657317008257 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 657317008258 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 657317008259 Walker B motif; other site