-- dump date 20140619_081022 -- class Genbank::misc_feature -- table misc_feature_note -- id note 885276000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 885276000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 885276000003 putative catalytic residues [active] 885276000004 putative nucleotide binding site [chemical binding]; other site 885276000005 putative aspartate binding site [chemical binding]; other site 885276000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 885276000007 dimer interface [polypeptide binding]; other site 885276000008 putative threonine allosteric regulatory site; other site 885276000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 885276000010 putative threonine allosteric regulatory site; other site 885276000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 885276000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 885276000013 homoserine kinase; Region: thrB; TIGR00191 885276000014 Protein of unknown function; Region: YhfT; pfam10797 885276000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 885276000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 885276000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 885276000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276000019 catalytic residue [active] 885276000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 885276000021 hypothetical protein; Validated; Region: PRK02101 885276000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 885276000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 885276000024 transaldolase-like protein; Provisional; Region: PTZ00411 885276000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 885276000026 active site 885276000027 dimer interface [polypeptide binding]; other site 885276000028 catalytic residue [active] 885276000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 885276000030 MPT binding site; other site 885276000031 trimer interface [polypeptide binding]; other site 885276000032 hypothetical protein; Provisional; Region: PRK10659 885276000033 hypothetical protein; Provisional; Region: PRK10236 885276000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 885276000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 885276000036 hypothetical protein; Provisional; Region: PRK10154 885276000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 885276000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 885276000039 nucleotide binding site [chemical binding]; other site 885276000040 NEF interaction site [polypeptide binding]; other site 885276000041 SBD interface [polypeptide binding]; other site 885276000042 chaperone protein DnaJ; Provisional; Region: PRK10767 885276000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885276000044 HSP70 interaction site [polypeptide binding]; other site 885276000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 885276000046 substrate binding site [polypeptide binding]; other site 885276000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 885276000048 Zn binding sites [ion binding]; other site 885276000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 885276000050 dimer interface [polypeptide binding]; other site 885276000051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 885276000052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885276000053 Sulfatase; Region: Sulfatase; pfam00884 885276000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 885276000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 885276000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 885276000058 putative dimerization interface [polypeptide binding]; other site 885276000059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 885276000060 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 885276000061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 885276000062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 885276000063 active site 885276000064 Riboflavin kinase; Region: Flavokinase; smart00904 885276000065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 885276000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 885276000067 HIGH motif; other site 885276000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 885276000069 active site 885276000070 KMSKS motif; other site 885276000071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 885276000072 tRNA binding surface [nucleotide binding]; other site 885276000073 anticodon binding site; other site 885276000074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 885276000075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 885276000076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 885276000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885276000078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 885276000079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 885276000080 Protein of unknown function (DUF805); Region: DUF805; pfam05656 885276000081 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 885276000082 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 885276000083 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 885276000084 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 885276000085 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 885276000086 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 885276000087 catalytic site [active] 885276000088 subunit interface [polypeptide binding]; other site 885276000089 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 885276000090 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 885276000091 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 885276000092 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 885276000093 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 885276000094 ATP-grasp domain; Region: ATP-grasp_4; cl17255 885276000095 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 885276000096 IMP binding site; other site 885276000097 dimer interface [polypeptide binding]; other site 885276000098 interdomain contacts; other site 885276000099 partial ornithine binding site; other site 885276000100 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 885276000101 carnitine operon protein CaiE; Provisional; Region: PRK13627 885276000102 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 885276000103 putative trimer interface [polypeptide binding]; other site 885276000104 putative metal binding site [ion binding]; other site 885276000105 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 885276000106 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885276000107 substrate binding site [chemical binding]; other site 885276000108 oxyanion hole (OAH) forming residues; other site 885276000109 trimer interface [polypeptide binding]; other site 885276000110 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 885276000111 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 885276000112 acyl-activating enzyme (AAE) consensus motif; other site 885276000113 putative AMP binding site [chemical binding]; other site 885276000114 putative active site [active] 885276000115 putative CoA binding site [chemical binding]; other site 885276000116 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 885276000117 CoA-transferase family III; Region: CoA_transf_3; pfam02515 885276000118 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 885276000119 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 885276000120 active site 885276000121 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 885276000122 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 885276000123 Ligand binding site [chemical binding]; other site 885276000124 Electron transfer flavoprotein domain; Region: ETF; pfam01012 885276000125 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 885276000126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 885276000127 Ligand binding site [chemical binding]; other site 885276000128 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 885276000129 putative oxidoreductase FixC; Provisional; Region: PRK10157 885276000130 ferredoxin-like protein FixX; Provisional; Region: PRK15449 885276000131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276000132 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 885276000133 putative substrate translocation pore; other site 885276000134 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 885276000135 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 885276000136 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 885276000137 TrkA-N domain; Region: TrkA_N; pfam02254 885276000138 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 885276000139 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 885276000140 folate binding site [chemical binding]; other site 885276000141 NADP+ binding site [chemical binding]; other site 885276000142 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 885276000143 CcdB protein; Region: CcdB; pfam01845 885276000144 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 885276000145 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 885276000146 active site 885276000147 metal binding site [ion binding]; metal-binding site 885276000148 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 885276000149 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 885276000150 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 885276000151 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 885276000152 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 885276000153 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 885276000154 SurA N-terminal domain; Region: SurA_N; pfam09312 885276000155 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 885276000156 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 885276000157 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 885276000158 OstA-like protein; Region: OstA; pfam03968 885276000159 Organic solvent tolerance protein; Region: OstA_C; pfam04453 885276000160 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 885276000161 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 885276000162 putative metal binding site [ion binding]; other site 885276000163 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885276000164 HSP70 interaction site [polypeptide binding]; other site 885276000165 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 885276000166 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 885276000167 active site 885276000168 ATP-dependent helicase HepA; Validated; Region: PRK04914 885276000169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276000170 ATP binding site [chemical binding]; other site 885276000171 putative Mg++ binding site [ion binding]; other site 885276000172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276000173 nucleotide binding region [chemical binding]; other site 885276000174 ATP-binding site [chemical binding]; other site 885276000175 DNA polymerase II; Reviewed; Region: PRK05762 885276000176 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 885276000177 active site 885276000178 catalytic site [active] 885276000179 substrate binding site [chemical binding]; other site 885276000180 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 885276000181 active site 885276000182 metal-binding site 885276000183 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885276000184 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885276000185 intersubunit interface [polypeptide binding]; other site 885276000186 active site 885276000187 Zn2+ binding site [ion binding]; other site 885276000188 L-arabinose isomerase; Provisional; Region: PRK02929 885276000189 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 885276000190 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 885276000191 trimer interface [polypeptide binding]; other site 885276000192 putative substrate binding site [chemical binding]; other site 885276000193 putative metal binding site [ion binding]; other site 885276000194 ribulokinase; Provisional; Region: PRK04123 885276000195 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 885276000196 N- and C-terminal domain interface [polypeptide binding]; other site 885276000197 active site 885276000198 MgATP binding site [chemical binding]; other site 885276000199 catalytic site [active] 885276000200 metal binding site [ion binding]; metal-binding site 885276000201 carbohydrate binding site [chemical binding]; other site 885276000202 homodimer interface [polypeptide binding]; other site 885276000203 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 885276000204 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885276000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276000206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276000207 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885276000208 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885276000209 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 885276000210 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 885276000211 Walker A/P-loop; other site 885276000212 ATP binding site [chemical binding]; other site 885276000213 Q-loop/lid; other site 885276000214 ABC transporter signature motif; other site 885276000215 Walker B; other site 885276000216 D-loop; other site 885276000217 H-loop/switch region; other site 885276000218 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 885276000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276000220 dimer interface [polypeptide binding]; other site 885276000221 conserved gate region; other site 885276000222 putative PBP binding loops; other site 885276000223 ABC-ATPase subunit interface; other site 885276000224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276000225 dimer interface [polypeptide binding]; other site 885276000226 conserved gate region; other site 885276000227 putative PBP binding loops; other site 885276000228 ABC-ATPase subunit interface; other site 885276000229 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 885276000230 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 885276000231 transcriptional regulator SgrR; Provisional; Region: PRK13626 885276000232 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 885276000233 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 885276000234 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 885276000235 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 885276000236 substrate binding site [chemical binding]; other site 885276000237 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 885276000238 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 885276000239 substrate binding site [chemical binding]; other site 885276000240 ligand binding site [chemical binding]; other site 885276000241 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 885276000242 tartrate dehydrogenase; Region: TTC; TIGR02089 885276000243 2-isopropylmalate synthase; Validated; Region: PRK00915 885276000244 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 885276000245 active site 885276000246 catalytic residues [active] 885276000247 metal binding site [ion binding]; metal-binding site 885276000248 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 885276000249 leu operon leader peptide; Provisional; Region: PRK09925 885276000250 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 885276000251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276000252 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 885276000253 putative substrate binding pocket [chemical binding]; other site 885276000254 putative dimerization interface [polypeptide binding]; other site 885276000255 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 885276000256 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 885276000257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885276000258 PYR/PP interface [polypeptide binding]; other site 885276000259 dimer interface [polypeptide binding]; other site 885276000260 TPP binding site [chemical binding]; other site 885276000261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885276000262 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 885276000263 TPP-binding site [chemical binding]; other site 885276000264 dimer interface [polypeptide binding]; other site 885276000265 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 885276000266 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 885276000267 putative valine binding site [chemical binding]; other site 885276000268 dimer interface [polypeptide binding]; other site 885276000269 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 885276000270 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 885276000271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276000272 DNA binding site [nucleotide binding] 885276000273 domain linker motif; other site 885276000274 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 885276000275 dimerization interface [polypeptide binding]; other site 885276000276 ligand binding site [chemical binding]; other site 885276000277 mraZ protein; Region: TIGR00242 885276000278 MraZ protein; Region: MraZ; pfam02381 885276000279 MraZ protein; Region: MraZ; pfam02381 885276000280 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 885276000281 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 885276000282 cell division protein FtsL; Provisional; Region: PRK10772 885276000283 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 885276000284 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 885276000285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 885276000286 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 885276000287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885276000288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885276000289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885276000290 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 885276000291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885276000292 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885276000293 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885276000294 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 885276000295 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 885276000296 Mg++ binding site [ion binding]; other site 885276000297 putative catalytic motif [active] 885276000298 putative substrate binding site [chemical binding]; other site 885276000299 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 885276000300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885276000301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885276000302 cell division protein FtsW; Provisional; Region: PRK10774 885276000303 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 885276000304 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 885276000305 active site 885276000306 homodimer interface [polypeptide binding]; other site 885276000307 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 885276000308 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885276000309 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885276000310 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885276000311 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 885276000312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 885276000313 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 885276000314 cell division protein FtsQ; Provisional; Region: PRK10775 885276000315 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 885276000316 Cell division protein FtsQ; Region: FtsQ; pfam03799 885276000317 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 885276000318 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276000319 Cell division protein FtsA; Region: FtsA; pfam14450 885276000320 cell division protein FtsZ; Validated; Region: PRK09330 885276000321 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 885276000322 nucleotide binding site [chemical binding]; other site 885276000323 SulA interaction site; other site 885276000324 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 885276000325 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 885276000326 SecA regulator SecM; Provisional; Region: PRK02943 885276000327 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 885276000328 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 885276000329 SEC-C motif; Region: SEC-C; pfam02810 885276000330 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 885276000331 active site 885276000332 8-oxo-dGMP binding site [chemical binding]; other site 885276000333 nudix motif; other site 885276000334 metal binding site [ion binding]; metal-binding site 885276000335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276000336 Helix-turn-helix domain; Region: HTH_28; pfam13518 885276000337 Helix-turn-helix domain; Region: HTH_28; pfam13518 885276000338 HTH-like domain; Region: HTH_21; pfam13276 885276000339 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 885276000340 Integrase core domain; Region: rve; pfam00665 885276000341 Integrase core domain; Region: rve_2; pfam13333 885276000342 DNA gyrase inhibitor; Reviewed; Region: PRK00418 885276000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 885276000344 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 885276000345 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 885276000346 CoA-binding site [chemical binding]; other site 885276000347 ATP-binding [chemical binding]; other site 885276000348 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 885276000349 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 885276000350 active site 885276000351 type IV pilin biogenesis protein; Provisional; Region: PRK10573 885276000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885276000353 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885276000354 hypothetical protein; Provisional; Region: PRK10436 885276000355 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 885276000356 Walker A motif; other site 885276000357 ATP binding site [chemical binding]; other site 885276000358 Walker B motif; other site 885276000359 putative major pilin subunit; Provisional; Region: PRK10574 885276000360 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885276000361 Pilin (bacterial filament); Region: Pilin; pfam00114 885276000362 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 885276000363 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 885276000364 dimerization interface [polypeptide binding]; other site 885276000365 active site 885276000366 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 885276000367 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 885276000368 amidase catalytic site [active] 885276000369 Zn binding residues [ion binding]; other site 885276000370 substrate binding site [chemical binding]; other site 885276000371 regulatory protein AmpE; Provisional; Region: PRK10987 885276000372 aromatic amino acid transporter; Provisional; Region: PRK10238 885276000373 Protein of unknown function (DUF796); Region: DUF796; cl01226 885276000374 S-type Pyocin; Region: Pyocin_S; pfam06958 885276000375 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 885276000376 active site 885276000377 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 885276000378 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 885276000379 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 885276000380 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885276000381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276000382 DNA-binding site [nucleotide binding]; DNA binding site 885276000383 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276000384 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 885276000385 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 885276000386 dimer interface [polypeptide binding]; other site 885276000387 TPP-binding site [chemical binding]; other site 885276000388 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 885276000389 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885276000390 E3 interaction surface; other site 885276000391 lipoyl attachment site [posttranslational modification]; other site 885276000392 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885276000393 E3 interaction surface; other site 885276000394 lipoyl attachment site [posttranslational modification]; other site 885276000395 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885276000396 E3 interaction surface; other site 885276000397 lipoyl attachment site [posttranslational modification]; other site 885276000398 e3 binding domain; Region: E3_binding; pfam02817 885276000399 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 885276000400 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 885276000401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885276000402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276000403 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885276000404 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 885276000405 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 885276000406 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 885276000407 substrate binding site [chemical binding]; other site 885276000408 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 885276000409 substrate binding site [chemical binding]; other site 885276000410 ligand binding site [chemical binding]; other site 885276000411 hypothetical protein; Provisional; Region: PRK05248 885276000412 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 885276000413 spermidine synthase; Provisional; Region: PRK00811 885276000414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276000415 S-adenosylmethionine binding site [chemical binding]; other site 885276000416 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 885276000417 multicopper oxidase; Provisional; Region: PRK10965 885276000418 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 885276000419 Multicopper oxidase; Region: Cu-oxidase; pfam00394 885276000420 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 885276000421 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 885276000422 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 885276000423 Trp docking motif [polypeptide binding]; other site 885276000424 putative active site [active] 885276000425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276000426 active site 885276000427 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 885276000428 active site clefts [active] 885276000429 zinc binding site [ion binding]; other site 885276000430 dimer interface [polypeptide binding]; other site 885276000431 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 885276000432 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885276000433 Walker A/P-loop; other site 885276000434 ATP binding site [chemical binding]; other site 885276000435 Q-loop/lid; other site 885276000436 ABC transporter signature motif; other site 885276000437 Walker B; other site 885276000438 D-loop; other site 885276000439 H-loop/switch region; other site 885276000440 inner membrane transport permease; Provisional; Region: PRK15066 885276000441 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885276000442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885276000443 active pocket/dimerization site; other site 885276000444 active site 885276000445 phosphorylation site [posttranslational modification] 885276000446 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 885276000447 putative active site [active] 885276000448 putative metal binding site [ion binding]; other site 885276000449 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 885276000450 tetramerization interface [polypeptide binding]; other site 885276000451 active site 885276000452 Uncharacterized conserved protein [Function unknown]; Region: COG5464 885276000453 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885276000454 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 885276000455 pantoate--beta-alanine ligase; Region: panC; TIGR00018 885276000456 Pantoate-beta-alanine ligase; Region: PanC; cd00560 885276000457 active site 885276000458 ATP-binding site [chemical binding]; other site 885276000459 pantoate-binding site; other site 885276000460 HXXH motif; other site 885276000461 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 885276000462 oligomerization interface [polypeptide binding]; other site 885276000463 active site 885276000464 metal binding site [ion binding]; metal-binding site 885276000465 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 885276000466 putative fimbrial protein StaF; Provisional; Region: PRK15262 885276000467 putative fimbrial protein StaE; Provisional; Region: PRK15263 885276000468 Fimbrial protein; Region: Fimbrial; cl01416 885276000469 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 885276000470 PapC N-terminal domain; Region: PapC_N; pfam13954 885276000471 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276000472 PapC C-terminal domain; Region: PapC_C; pfam13953 885276000473 putative chaperone protein EcpD; Provisional; Region: PRK09926 885276000474 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276000475 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276000476 Fimbrial protein; Region: Fimbrial; cl01416 885276000477 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 885276000478 catalytic center binding site [active] 885276000479 ATP binding site [chemical binding]; other site 885276000480 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 885276000481 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 885276000482 active site 885276000483 NTP binding site [chemical binding]; other site 885276000484 metal binding triad [ion binding]; metal-binding site 885276000485 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 885276000486 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 885276000487 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 885276000488 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 885276000489 active site 885276000490 nucleotide binding site [chemical binding]; other site 885276000491 HIGH motif; other site 885276000492 KMSKS motif; other site 885276000493 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 885276000494 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 885276000495 2'-5' RNA ligase; Provisional; Region: PRK15124 885276000496 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 885276000497 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 885276000498 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 885276000499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276000500 ATP binding site [chemical binding]; other site 885276000501 putative Mg++ binding site [ion binding]; other site 885276000502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276000503 nucleotide binding region [chemical binding]; other site 885276000504 ATP-binding site [chemical binding]; other site 885276000505 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 885276000506 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 885276000507 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 885276000508 Transglycosylase; Region: Transgly; pfam00912 885276000509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 885276000510 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 885276000511 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276000512 N-terminal plug; other site 885276000513 ligand-binding site [chemical binding]; other site 885276000514 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 885276000515 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276000516 Walker A/P-loop; other site 885276000517 ATP binding site [chemical binding]; other site 885276000518 Q-loop/lid; other site 885276000519 ABC transporter signature motif; other site 885276000520 Walker B; other site 885276000521 D-loop; other site 885276000522 H-loop/switch region; other site 885276000523 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 885276000524 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885276000525 siderophore binding site; other site 885276000526 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885276000527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276000528 ABC-ATPase subunit interface; other site 885276000529 dimer interface [polypeptide binding]; other site 885276000530 putative PBP binding regions; other site 885276000531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276000532 ABC-ATPase subunit interface; other site 885276000533 dimer interface [polypeptide binding]; other site 885276000534 putative PBP binding regions; other site 885276000535 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 885276000536 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885276000537 inhibitor-cofactor binding pocket; inhibition site 885276000538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276000539 catalytic residue [active] 885276000540 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 885276000541 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 885276000542 Cl- selectivity filter; other site 885276000543 Cl- binding residues [ion binding]; other site 885276000544 pore gating glutamate residue; other site 885276000545 dimer interface [polypeptide binding]; other site 885276000546 H+/Cl- coupling transport residue; other site 885276000547 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 885276000548 hypothetical protein; Provisional; Region: PRK10578 885276000549 UPF0126 domain; Region: UPF0126; pfam03458 885276000550 UPF0126 domain; Region: UPF0126; pfam03458 885276000551 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 885276000552 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 885276000553 cobalamin binding residues [chemical binding]; other site 885276000554 putative BtuC binding residues; other site 885276000555 dimer interface [polypeptide binding]; other site 885276000556 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 885276000557 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 885276000558 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 885276000559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885276000560 Zn2+ binding site [ion binding]; other site 885276000561 Mg2+ binding site [ion binding]; other site 885276000562 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 885276000563 serine endoprotease; Provisional; Region: PRK10942 885276000564 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 885276000565 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885276000566 protein binding site [polypeptide binding]; other site 885276000567 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885276000568 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 885276000569 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 885276000570 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 885276000571 hypothetical protein; Provisional; Region: PRK13677 885276000572 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 885276000573 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 885276000574 trimer interface [polypeptide binding]; other site 885276000575 active site 885276000576 substrate binding site [chemical binding]; other site 885276000577 CoA binding site [chemical binding]; other site 885276000578 PII uridylyl-transferase; Provisional; Region: PRK05007 885276000579 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 885276000580 metal binding triad; other site 885276000581 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 885276000582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885276000583 Zn2+ binding site [ion binding]; other site 885276000584 Mg2+ binding site [ion binding]; other site 885276000585 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 885276000586 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 885276000587 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 885276000588 active site 885276000589 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 885276000590 rRNA interaction site [nucleotide binding]; other site 885276000591 S8 interaction site; other site 885276000592 putative laminin-1 binding site; other site 885276000593 elongation factor Ts; Provisional; Region: tsf; PRK09377 885276000594 UBA/TS-N domain; Region: UBA; pfam00627 885276000595 Elongation factor TS; Region: EF_TS; pfam00889 885276000596 Elongation factor TS; Region: EF_TS; pfam00889 885276000597 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 885276000598 putative nucleotide binding site [chemical binding]; other site 885276000599 uridine monophosphate binding site [chemical binding]; other site 885276000600 homohexameric interface [polypeptide binding]; other site 885276000601 ribosome recycling factor; Reviewed; Region: frr; PRK00083 885276000602 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 885276000603 hinge region; other site 885276000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 885276000605 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 885276000606 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 885276000607 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 885276000608 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 885276000609 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 885276000610 catalytic residue [active] 885276000611 putative FPP diphosphate binding site; other site 885276000612 putative FPP binding hydrophobic cleft; other site 885276000613 dimer interface [polypeptide binding]; other site 885276000614 putative IPP diphosphate binding site; other site 885276000615 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 885276000616 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 885276000617 zinc metallopeptidase RseP; Provisional; Region: PRK10779 885276000618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 885276000619 active site 885276000620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 885276000621 protein binding site [polypeptide binding]; other site 885276000622 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 885276000623 putative substrate binding region [chemical binding]; other site 885276000624 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 885276000625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885276000626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885276000627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885276000628 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885276000629 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885276000630 Surface antigen; Region: Bac_surface_Ag; pfam01103 885276000631 periplasmic chaperone; Provisional; Region: PRK10780 885276000632 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 885276000633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 885276000634 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 885276000635 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 885276000636 trimer interface [polypeptide binding]; other site 885276000637 active site 885276000638 UDP-GlcNAc binding site [chemical binding]; other site 885276000639 lipid binding site [chemical binding]; lipid-binding site 885276000640 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 885276000641 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 885276000642 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 885276000643 active site 885276000644 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 885276000645 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 885276000646 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 885276000647 RNA/DNA hybrid binding site [nucleotide binding]; other site 885276000648 active site 885276000649 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 885276000650 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 885276000651 putative active site [active] 885276000652 putative PHP Thumb interface [polypeptide binding]; other site 885276000653 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 885276000654 generic binding surface II; other site 885276000655 generic binding surface I; other site 885276000656 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 885276000657 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 885276000658 lysine decarboxylase LdcC; Provisional; Region: PRK15399 885276000659 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885276000660 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885276000661 homodimer interface [polypeptide binding]; other site 885276000662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276000663 catalytic residue [active] 885276000664 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885276000665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 885276000666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 885276000667 putative metal binding site [ion binding]; other site 885276000668 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 885276000669 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 885276000670 Ligand Binding Site [chemical binding]; other site 885276000671 TilS substrate binding domain; Region: TilS; pfam09179 885276000672 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 885276000673 Rho-binding antiterminator; Provisional; Region: PRK11625 885276000674 hypothetical protein; Provisional; Region: PRK04964 885276000675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 885276000676 hypothetical protein; Provisional; Region: PRK09256 885276000677 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 885276000678 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 885276000679 NlpE N-terminal domain; Region: NlpE; pfam04170 885276000680 HTH-like domain; Region: HTH_21; pfam13276 885276000681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 885276000682 Integrase core domain; Region: rve; pfam00665 885276000683 Integrase core domain; Region: rve_2; pfam13333 885276000684 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276000685 Helix-turn-helix domain; Region: HTH_28; pfam13518 885276000686 Helix-turn-helix domain; Region: HTH_28; pfam13518 885276000687 hypothetical protein; Provisional; Region: PRK11479 885276000688 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 885276000689 prolyl-tRNA synthetase; Provisional; Region: PRK09194 885276000690 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 885276000691 dimer interface [polypeptide binding]; other site 885276000692 motif 1; other site 885276000693 active site 885276000694 motif 2; other site 885276000695 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 885276000696 putative deacylase active site [active] 885276000697 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 885276000698 active site 885276000699 motif 3; other site 885276000700 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 885276000701 anticodon binding site; other site 885276000702 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 885276000703 homodimer interaction site [polypeptide binding]; other site 885276000704 cofactor binding site; other site 885276000705 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 885276000706 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 885276000707 lipoprotein, YaeC family; Region: TIGR00363 885276000708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276000709 dimer interface [polypeptide binding]; other site 885276000710 conserved gate region; other site 885276000711 ABC-ATPase subunit interface; other site 885276000712 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 885276000713 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 885276000714 Walker A/P-loop; other site 885276000715 ATP binding site [chemical binding]; other site 885276000716 Q-loop/lid; other site 885276000717 ABC transporter signature motif; other site 885276000718 Walker B; other site 885276000719 D-loop; other site 885276000720 H-loop/switch region; other site 885276000721 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 885276000722 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 885276000723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276000724 active site 885276000725 motif I; other site 885276000726 motif II; other site 885276000727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276000728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276000729 active site 885276000730 catalytic tetrad [active] 885276000731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276000732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276000733 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 885276000734 putative effector binding pocket; other site 885276000735 dimerization interface [polypeptide binding]; other site 885276000736 hypothetical protein; Provisional; Region: PRK05421 885276000737 putative catalytic site [active] 885276000738 putative metal binding site [ion binding]; other site 885276000739 putative phosphate binding site [ion binding]; other site 885276000740 putative catalytic site [active] 885276000741 putative phosphate binding site [ion binding]; other site 885276000742 putative metal binding site [ion binding]; other site 885276000743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276000744 S-adenosylmethionine binding site [chemical binding]; other site 885276000745 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 885276000746 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885276000747 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885276000748 catalytic residue [active] 885276000749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276000750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276000751 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 885276000752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276000753 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 885276000754 RNA/DNA hybrid binding site [nucleotide binding]; other site 885276000755 active site 885276000756 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 885276000757 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 885276000758 active site 885276000759 catalytic site [active] 885276000760 substrate binding site [chemical binding]; other site 885276000761 Methyltransferase domain; Region: Methyltransf_27; pfam13708 885276000762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276000763 Transposase; Region: HTH_Tnp_1; pfam01527 885276000764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885276000765 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 885276000766 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 885276000767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885276000768 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 885276000769 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 885276000770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885276000771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 885276000772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 885276000773 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 885276000774 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276000775 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885276000776 active site 885276000777 Int/Topo IB signature motif; other site 885276000778 BRO family, N-terminal domain; Region: Bro-N; cl10591 885276000779 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 885276000780 AAA domain; Region: AAA_25; pfam13481 885276000781 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 885276000782 Walker A motif; other site 885276000783 ATP binding site [chemical binding]; other site 885276000784 Walker B motif; other site 885276000785 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 885276000786 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 885276000787 ssDNA binding site [nucleotide binding]; other site 885276000788 dimer interface [polypeptide binding]; other site 885276000789 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885276000790 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 885276000791 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 885276000792 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 885276000793 Transposase; Region: DEDD_Tnp_IS110; pfam01548 885276000794 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 885276000795 Homeodomain-like domain; Region: HTH_23; pfam13384 885276000796 Winged helix-turn helix; Region: HTH_29; pfam13551 885276000797 Homeodomain-like domain; Region: HTH_32; pfam13565 885276000798 DDE superfamily endonuclease; Region: DDE_3; pfam13358 885276000799 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885276000800 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 885276000801 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885276000802 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885276000803 MPN+ (JAMM) motif; other site 885276000804 Zinc-binding site [ion binding]; other site 885276000805 potential frameshift: common BLAST hit: gi|218697845|ref|YP_002405512.1| antirestriction protein 885276000806 Antirestriction protein; Region: Antirestrict; pfam03230 885276000807 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885276000808 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 885276000809 Photosystem II protein; Region: PSII; cl08223 885276000810 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 885276000811 nucleophile elbow; other site 885276000812 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 885276000813 YjcZ-like protein; Region: YjcZ; pfam13990 885276000814 hypothetical protein; Provisional; Region: PRK09866 885276000815 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276000816 G1 box; other site 885276000817 GTP/Mg2+ binding site [chemical binding]; other site 885276000818 G2 box; other site 885276000819 Switch I region; other site 885276000820 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276000821 G3 box; other site 885276000822 Switch II region; other site 885276000823 GTP/Mg2+ binding site [chemical binding]; other site 885276000824 G4 box; other site 885276000825 G5 box; other site 885276000826 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276000827 G1 box; other site 885276000828 GTP/Mg2+ binding site [chemical binding]; other site 885276000829 G2 box; other site 885276000830 Switch I region; other site 885276000831 Switch II region; other site 885276000832 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 885276000833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276000834 active site 885276000835 DNA binding site [nucleotide binding] 885276000836 Int/Topo IB signature motif; other site 885276000837 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885276000838 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276000839 N-terminal plug; other site 885276000840 ligand-binding site [chemical binding]; other site 885276000841 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 885276000842 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885276000843 putative ligand binding residues [chemical binding]; other site 885276000844 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276000845 dimer interface [polypeptide binding]; other site 885276000846 putative PBP binding regions; other site 885276000847 ABC-ATPase subunit interface; other site 885276000848 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885276000849 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276000850 Walker A/P-loop; other site 885276000851 ATP binding site [chemical binding]; other site 885276000852 Q-loop/lid; other site 885276000853 ABC transporter signature motif; other site 885276000854 Walker B; other site 885276000855 D-loop; other site 885276000856 H-loop/switch region; other site 885276000857 Haemolysin expression modulating protein; Region: HHA; pfam05321 885276000858 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276000859 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885276000860 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885276000861 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276000862 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276000863 hypothetical protein; Provisional; Region: PRK09273 885276000864 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 885276000865 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 885276000866 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 885276000867 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 885276000868 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885276000869 NADP binding site [chemical binding]; other site 885276000870 homodimer interface [polypeptide binding]; other site 885276000871 active site 885276000872 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 885276000873 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 885276000874 Right handed beta helix region; Region: Beta_helix; pfam13229 885276000875 CAAX protease self-immunity; Region: Abi; pfam02517 885276000876 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 885276000877 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 885276000878 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276000879 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276000880 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 885276000881 substrate binding site [chemical binding]; other site 885276000882 dimer interface [polypeptide binding]; other site 885276000883 ATP binding site [chemical binding]; other site 885276000884 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 885276000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276000886 putative substrate translocation pore; other site 885276000887 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 885276000888 active site 885276000889 catalytic residues [active] 885276000890 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 885276000891 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 885276000892 active site 885276000893 P-loop; other site 885276000894 phosphorylation site [posttranslational modification] 885276000895 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276000896 active site 885276000897 phosphorylation site [posttranslational modification] 885276000898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885276000899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276000900 DNA binding site [nucleotide binding] 885276000901 domain linker motif; other site 885276000902 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 885276000903 putative dimerization interface [polypeptide binding]; other site 885276000904 putative ligand binding site [chemical binding]; other site 885276000905 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 885276000906 haemagglutination activity domain; Region: Haemagg_act; pfam05860 885276000907 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885276000908 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885276000909 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885276000910 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 885276000911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 885276000912 MULE transposase domain; Region: MULE; pfam10551 885276000913 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 885276000914 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 885276000915 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 885276000916 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276000917 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276000918 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885276000919 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885276000920 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 885276000921 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 885276000922 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 885276000923 putative active site [active] 885276000924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276000925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276000926 Walker A/P-loop; other site 885276000927 ATP binding site [chemical binding]; other site 885276000928 Q-loop/lid; other site 885276000929 ABC transporter signature motif; other site 885276000930 Walker B; other site 885276000931 D-loop; other site 885276000932 H-loop/switch region; other site 885276000933 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 885276000934 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276000935 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276000936 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 885276000937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276000938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276000939 DNA binding residues [nucleotide binding] 885276000940 dimerization interface [polypeptide binding]; other site 885276000941 potential frameshift: common BLAST hit: gi|110642861|ref|YP_670591.1| transposase 885276000942 DDE superfamily endonuclease; Region: DDE_3; pfam13358 885276000943 Homeodomain-like domain; Region: HTH_23; pfam13384 885276000944 Winged helix-turn helix; Region: HTH_29; pfam13551 885276000945 Winged helix-turn helix; Region: HTH_33; pfam13592 885276000946 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 885276000947 C-N hydrolase family amidase; Provisional; Region: PRK10438 885276000948 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 885276000949 putative active site [active] 885276000950 catalytic triad [active] 885276000951 dimer interface [polypeptide binding]; other site 885276000952 multimer interface [polypeptide binding]; other site 885276000953 C-lysozyme inhibitor; Provisional; Region: PRK09993 885276000954 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 885276000955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 885276000956 active site 885276000957 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 885276000958 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 885276000959 dimer interface [polypeptide binding]; other site 885276000960 active site 885276000961 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 885276000962 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 885276000963 putative active site [active] 885276000964 putative dimer interface [polypeptide binding]; other site 885276000965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 885276000966 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276000967 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885276000968 NlpC/P60 family; Region: NLPC_P60; pfam00877 885276000969 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 885276000970 FHIPEP family; Region: FHIPEP; pfam00771 885276000971 hypothetical protein; Validated; Region: PRK06778 885276000972 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276000973 ligand binding site [chemical binding]; other site 885276000974 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 885276000975 active site 885276000976 DNA polymerase IV; Validated; Region: PRK02406 885276000977 DNA binding site [nucleotide binding] 885276000978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 885276000979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276000980 Coenzyme A binding pocket [chemical binding]; other site 885276000981 hypothetical protein; Reviewed; Region: PRK09588 885276000982 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 885276000983 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 885276000984 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 885276000985 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 885276000986 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 885276000987 metal binding site [ion binding]; metal-binding site 885276000988 dimer interface [polypeptide binding]; other site 885276000989 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276000990 active site 885276000991 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 885276000992 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 885276000993 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276000994 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276000995 trimer interface [polypeptide binding]; other site 885276000996 eyelet of channel; other site 885276000997 gamma-glutamyl kinase; Provisional; Region: PRK05429 885276000998 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 885276000999 nucleotide binding site [chemical binding]; other site 885276001000 homotetrameric interface [polypeptide binding]; other site 885276001001 putative phosphate binding site [ion binding]; other site 885276001002 putative allosteric binding site; other site 885276001003 PUA domain; Region: PUA; pfam01472 885276001004 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 885276001005 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 885276001006 putative catalytic cysteine [active] 885276001007 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 885276001008 MarR family; Region: MarR_2; cl17246 885276001009 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885276001010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885276001011 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 885276001012 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885276001013 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885276001014 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 885276001015 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 885276001016 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 885276001017 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276001018 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 885276001019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276001020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276001021 DNA binding residues [nucleotide binding] 885276001022 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 885276001023 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 885276001024 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 885276001025 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 885276001026 putative active site [active] 885276001027 putative FMN binding site [chemical binding]; other site 885276001028 putative substrate binding site [chemical binding]; other site 885276001029 putative catalytic residue [active] 885276001030 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 885276001031 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276001032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276001033 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 885276001034 putative effector binding pocket; other site 885276001035 putative dimerization interface [polypeptide binding]; other site 885276001036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276001037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276001038 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 885276001039 putative effector binding pocket; other site 885276001040 putative dimerization interface [polypeptide binding]; other site 885276001041 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276001042 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276001043 active site 885276001044 catalytic tetrad [active] 885276001045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276001046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276001047 active site 885276001048 catalytic tetrad [active] 885276001049 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885276001050 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885276001051 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885276001052 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885276001053 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885276001054 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 885276001055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276001056 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 885276001057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276001058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276001059 active site 885276001060 catalytic tetrad [active] 885276001061 Predicted membrane protein [Function unknown]; Region: COG3059 885276001062 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276001063 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 885276001064 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 885276001065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276001066 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885276001067 Cupin; Region: Cupin_6; pfam12852 885276001068 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 885276001069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276001070 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 885276001071 Cysteine-rich domain; Region: CCG; pfam02754 885276001072 Cysteine-rich domain; Region: CCG; pfam02754 885276001073 iron-sulfur cluster-binding protein; Region: TIGR00273 885276001074 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 885276001075 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276001076 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 885276001077 Uncharacterized conserved protein [Function unknown]; Region: COG1556 885276001078 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 885276001079 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 885276001080 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276001081 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276001082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276001083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276001084 DNA binding residues [nucleotide binding] 885276001085 dimerization interface [polypeptide binding]; other site 885276001086 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276001087 active site 885276001088 DNA binding site [nucleotide binding] 885276001089 Int/Topo IB signature motif; other site 885276001090 choline dehydrogenase; Validated; Region: PRK02106 885276001091 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 885276001092 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 885276001093 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 885276001094 tetrameric interface [polypeptide binding]; other site 885276001095 NAD binding site [chemical binding]; other site 885276001096 catalytic residues [active] 885276001097 transcriptional regulator BetI; Validated; Region: PRK00767 885276001098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276001099 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 885276001100 choline transport protein BetT; Provisional; Region: PRK09928 885276001101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276001102 DNA binding residues [nucleotide binding] 885276001103 dimerization interface [polypeptide binding]; other site 885276001104 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276001105 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 885276001106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276001107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276001108 dimerization interface [polypeptide binding]; other site 885276001109 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 885276001110 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 885276001111 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 885276001112 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 885276001113 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 885276001114 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 885276001115 CoA binding domain; Region: CoA_binding; pfam02629 885276001116 CoA-ligase; Region: Ligase_CoA; pfam00549 885276001117 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 885276001118 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 885276001119 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885276001120 putative substrate binding site [chemical binding]; other site 885276001121 nucleotide binding site [chemical binding]; other site 885276001122 nucleotide binding site [chemical binding]; other site 885276001123 homodimer interface [polypeptide binding]; other site 885276001124 putative deaminase; Validated; Region: PRK06846 885276001125 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 885276001126 active site 885276001127 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 885276001128 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 885276001129 putative NAD(P) binding site [chemical binding]; other site 885276001130 putative substrate binding site [chemical binding]; other site 885276001131 catalytic Zn binding site [ion binding]; other site 885276001132 structural Zn binding site [ion binding]; other site 885276001133 dimer interface [polypeptide binding]; other site 885276001134 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 885276001135 hypothetical protein; Provisional; Region: PRK09929 885276001136 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 885276001137 Propionate catabolism activator; Region: PrpR_N; pfam06506 885276001138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276001139 Walker A motif; other site 885276001140 ATP binding site [chemical binding]; other site 885276001141 Walker B motif; other site 885276001142 arginine finger; other site 885276001143 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276001144 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 885276001145 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 885276001146 tetramer interface [polypeptide binding]; other site 885276001147 active site 885276001148 Mg2+/Mn2+ binding site [ion binding]; other site 885276001149 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 885276001150 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 885276001151 dimer interface [polypeptide binding]; other site 885276001152 active site 885276001153 citrylCoA binding site [chemical binding]; other site 885276001154 oxalacetate/citrate binding site [chemical binding]; other site 885276001155 coenzyme A binding site [chemical binding]; other site 885276001156 catalytic triad [active] 885276001157 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 885276001158 2-methylcitrate dehydratase; Region: prpD; TIGR02330 885276001159 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 885276001160 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 885276001161 acyl-activating enzyme (AAE) consensus motif; other site 885276001162 putative AMP binding site [chemical binding]; other site 885276001163 putative active site [active] 885276001164 putative CoA binding site [chemical binding]; other site 885276001165 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 885276001166 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 885276001167 Na binding site [ion binding]; other site 885276001168 putative substrate binding site [chemical binding]; other site 885276001169 cytosine deaminase; Provisional; Region: PRK09230 885276001170 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 885276001171 active site 885276001172 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 885276001173 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 885276001174 active site 885276001175 substrate binding site [chemical binding]; other site 885276001176 trimer interface [polypeptide binding]; other site 885276001177 CoA binding site [chemical binding]; other site 885276001178 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 885276001179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276001180 putative substrate translocation pore; other site 885276001181 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 885276001182 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 885276001183 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 885276001184 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 885276001185 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 885276001186 lac repressor; Reviewed; Region: lacI; PRK09526 885276001187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276001188 DNA binding site [nucleotide binding] 885276001189 domain linker motif; other site 885276001190 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 885276001191 ligand binding site [chemical binding]; other site 885276001192 dimerization interface (open form) [polypeptide binding]; other site 885276001193 dimerization interface (closed form) [polypeptide binding]; other site 885276001194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 885276001195 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 885276001196 S-formylglutathione hydrolase; Region: PLN02442 885276001197 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 885276001198 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 885276001199 substrate binding site [chemical binding]; other site 885276001200 catalytic Zn binding site [ion binding]; other site 885276001201 NAD binding site [chemical binding]; other site 885276001202 structural Zn binding site [ion binding]; other site 885276001203 dimer interface [polypeptide binding]; other site 885276001204 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 885276001205 putative metal binding site [ion binding]; other site 885276001206 putative homodimer interface [polypeptide binding]; other site 885276001207 putative homotetramer interface [polypeptide binding]; other site 885276001208 putative homodimer-homodimer interface [polypeptide binding]; other site 885276001209 putative allosteric switch controlling residues; other site 885276001210 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 885276001211 putative trimer interface [polypeptide binding]; other site 885276001212 putative CoA binding site [chemical binding]; other site 885276001213 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 885276001214 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 885276001215 DXD motif; other site 885276001216 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 885276001217 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 885276001218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276001219 substrate binding pocket [chemical binding]; other site 885276001220 membrane-bound complex binding site; other site 885276001221 hinge residues; other site 885276001222 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 885276001223 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 885276001224 Walker A/P-loop; other site 885276001225 ATP binding site [chemical binding]; other site 885276001226 Q-loop/lid; other site 885276001227 ABC transporter signature motif; other site 885276001228 Walker B; other site 885276001229 D-loop; other site 885276001230 H-loop/switch region; other site 885276001231 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 885276001232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276001233 dimer interface [polypeptide binding]; other site 885276001234 conserved gate region; other site 885276001235 putative PBP binding loops; other site 885276001236 ABC-ATPase subunit interface; other site 885276001237 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 885276001238 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 885276001239 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 885276001240 dimer interface [polypeptide binding]; other site 885276001241 active site 885276001242 Schiff base residues; other site 885276001243 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 885276001244 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276001245 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276001246 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 885276001247 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 885276001248 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 885276001249 microcin B17 transporter; Reviewed; Region: PRK11098 885276001250 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 885276001251 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 885276001252 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 885276001253 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 885276001254 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 885276001255 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 885276001256 anti-RssB factor; Provisional; Region: PRK10244 885276001257 alkaline phosphatase; Provisional; Region: PRK10518 885276001258 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 885276001259 dimer interface [polypeptide binding]; other site 885276001260 active site 885276001261 hypothetical protein; Provisional; Region: PRK11505 885276001262 psiF repeat; Region: PsiF_repeat; pfam07769 885276001263 psiF repeat; Region: PsiF_repeat; pfam07769 885276001264 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 885276001265 MASE2 domain; Region: MASE2; pfam05230 885276001266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276001267 metal binding site [ion binding]; metal-binding site 885276001268 active site 885276001269 I-site; other site 885276001270 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 885276001271 pyrroline-5-carboxylate reductase; Region: PLN02688 885276001272 hypothetical protein; Validated; Region: PRK00124 885276001273 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 885276001274 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 885276001275 ADP binding site [chemical binding]; other site 885276001276 magnesium binding site [ion binding]; other site 885276001277 putative shikimate binding site; other site 885276001278 hypothetical protein; Provisional; Region: PRK10380 885276001279 hypothetical protein; Provisional; Region: PRK10481 885276001280 hypothetical protein; Provisional; Region: PRK10579 885276001281 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 885276001282 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 885276001283 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 885276001284 fructokinase; Reviewed; Region: PRK09557 885276001285 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276001286 nucleotide binding site [chemical binding]; other site 885276001287 MFS transport protein AraJ; Provisional; Region: PRK10091 885276001288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276001289 putative substrate translocation pore; other site 885276001290 exonuclease subunit SbcC; Provisional; Region: PRK10246 885276001291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276001292 Walker A/P-loop; other site 885276001293 ATP binding site [chemical binding]; other site 885276001294 Q-loop/lid; other site 885276001295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276001296 ABC transporter signature motif; other site 885276001297 Walker B; other site 885276001298 D-loop; other site 885276001299 H-loop/switch region; other site 885276001300 exonuclease subunit SbcD; Provisional; Region: PRK10966 885276001301 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 885276001302 active site 885276001303 metal binding site [ion binding]; metal-binding site 885276001304 DNA binding site [nucleotide binding] 885276001305 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 885276001306 transcriptional regulator PhoB; Provisional; Region: PRK10161 885276001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276001308 active site 885276001309 phosphorylation site [posttranslational modification] 885276001310 intermolecular recognition site; other site 885276001311 dimerization interface [polypeptide binding]; other site 885276001312 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276001313 DNA binding site [nucleotide binding] 885276001314 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 885276001315 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 885276001316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276001317 putative active site [active] 885276001318 heme pocket [chemical binding]; other site 885276001319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276001320 dimer interface [polypeptide binding]; other site 885276001321 phosphorylation site [posttranslational modification] 885276001322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276001323 ATP binding site [chemical binding]; other site 885276001324 Mg2+ binding site [ion binding]; other site 885276001325 G-X-G motif; other site 885276001326 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 885276001327 putative proline-specific permease; Provisional; Region: proY; PRK10580 885276001328 Spore germination protein; Region: Spore_permease; cl17796 885276001329 maltodextrin glucosidase; Provisional; Region: PRK10785 885276001330 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 885276001331 homodimer interface [polypeptide binding]; other site 885276001332 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 885276001333 active site 885276001334 homodimer interface [polypeptide binding]; other site 885276001335 catalytic site [active] 885276001336 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 885276001337 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 885276001338 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 885276001339 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 885276001340 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 885276001341 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 885276001342 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 885276001343 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 885276001344 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 885276001345 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 885276001346 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 885276001347 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 885276001348 Protein export membrane protein; Region: SecD_SecF; pfam02355 885276001349 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 885276001350 active site 885276001351 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 885276001352 hypothetical protein; Provisional; Region: PRK11530 885276001353 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 885276001354 ATP cone domain; Region: ATP-cone; pfam03477 885276001355 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 885276001356 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 885276001357 catalytic motif [active] 885276001358 Zn binding site [ion binding]; other site 885276001359 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 885276001360 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 885276001361 homopentamer interface [polypeptide binding]; other site 885276001362 active site 885276001363 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 885276001364 putative RNA binding site [nucleotide binding]; other site 885276001365 thiamine monophosphate kinase; Provisional; Region: PRK05731 885276001366 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 885276001367 ATP binding site [chemical binding]; other site 885276001368 dimerization interface [polypeptide binding]; other site 885276001369 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 885276001370 tetramer interfaces [polypeptide binding]; other site 885276001371 binuclear metal-binding site [ion binding]; other site 885276001372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276001373 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276001374 active site 885276001375 catalytic tetrad [active] 885276001376 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 885276001377 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 885276001378 TPP-binding site; other site 885276001379 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885276001380 PYR/PP interface [polypeptide binding]; other site 885276001381 dimer interface [polypeptide binding]; other site 885276001382 TPP binding site [chemical binding]; other site 885276001383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885276001384 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 885276001385 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 885276001386 substrate binding pocket [chemical binding]; other site 885276001387 chain length determination region; other site 885276001388 substrate-Mg2+ binding site; other site 885276001389 catalytic residues [active] 885276001390 aspartate-rich region 1; other site 885276001391 active site lid residues [active] 885276001392 aspartate-rich region 2; other site 885276001393 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 885276001394 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 885276001395 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 885276001396 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 885276001397 Ligand Binding Site [chemical binding]; other site 885276001398 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 885276001399 active site residue [active] 885276001400 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 885276001401 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 885276001402 conserved cys residue [active] 885276001403 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 885276001404 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 885276001405 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 885276001406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 885276001407 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 885276001408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276001409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276001410 putative substrate translocation pore; other site 885276001411 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 885276001412 UbiA prenyltransferase family; Region: UbiA; pfam01040 885276001413 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 885276001414 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 885276001415 Subunit I/III interface [polypeptide binding]; other site 885276001416 Subunit III/IV interface [polypeptide binding]; other site 885276001417 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 885276001418 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 885276001419 D-pathway; other site 885276001420 Putative ubiquinol binding site [chemical binding]; other site 885276001421 Low-spin heme (heme b) binding site [chemical binding]; other site 885276001422 Putative water exit pathway; other site 885276001423 Binuclear center (heme o3/CuB) [ion binding]; other site 885276001424 K-pathway; other site 885276001425 Putative proton exit pathway; other site 885276001426 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 885276001427 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 885276001428 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 885276001429 muropeptide transporter; Reviewed; Region: ampG; PRK11902 885276001430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276001431 putative substrate translocation pore; other site 885276001432 hypothetical protein; Provisional; Region: PRK11627 885276001433 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 885276001434 transcriptional regulator BolA; Provisional; Region: PRK11628 885276001435 trigger factor; Provisional; Region: tig; PRK01490 885276001436 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885276001437 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 885276001438 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 885276001439 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 885276001440 oligomer interface [polypeptide binding]; other site 885276001441 active site residues [active] 885276001442 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 885276001443 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 885276001444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276001445 Walker A motif; other site 885276001446 ATP binding site [chemical binding]; other site 885276001447 Walker B motif; other site 885276001448 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 885276001449 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 885276001450 Found in ATP-dependent protease La (LON); Region: LON; smart00464 885276001451 Found in ATP-dependent protease La (LON); Region: LON; smart00464 885276001452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276001453 Walker A motif; other site 885276001454 ATP binding site [chemical binding]; other site 885276001455 Walker B motif; other site 885276001456 arginine finger; other site 885276001457 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 885276001458 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885276001459 IHF dimer interface [polypeptide binding]; other site 885276001460 IHF - DNA interface [nucleotide binding]; other site 885276001461 periplasmic folding chaperone; Provisional; Region: PRK10788 885276001462 SurA N-terminal domain; Region: SurA_N_3; cl07813 885276001463 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 885276001464 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 885276001465 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 885276001466 active site 885276001467 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 885276001468 Ligand Binding Site [chemical binding]; other site 885276001469 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 885276001470 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 885276001471 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 885276001472 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 885276001473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276001474 active site 885276001475 motif I; other site 885276001476 motif II; other site 885276001477 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276001478 dimerization interface [polypeptide binding]; other site 885276001479 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 885276001480 putative DNA binding site [nucleotide binding]; other site 885276001481 putative Zn2+ binding site [ion binding]; other site 885276001482 AsnC family; Region: AsnC_trans_reg; pfam01037 885276001483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276001484 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 885276001485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276001486 Walker A/P-loop; other site 885276001487 ATP binding site [chemical binding]; other site 885276001488 Q-loop/lid; other site 885276001489 ABC transporter signature motif; other site 885276001490 Walker B; other site 885276001491 D-loop; other site 885276001492 H-loop/switch region; other site 885276001493 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 885276001494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276001495 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 885276001496 Walker A/P-loop; other site 885276001497 ATP binding site [chemical binding]; other site 885276001498 Q-loop/lid; other site 885276001499 ABC transporter signature motif; other site 885276001500 Walker B; other site 885276001501 D-loop; other site 885276001502 H-loop/switch region; other site 885276001503 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 885276001504 Nitrogen regulatory protein P-II; Region: P-II; smart00938 885276001505 ammonium transporter; Provisional; Region: PRK10666 885276001506 acyl-CoA thioesterase II; Provisional; Region: PRK10526 885276001507 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 885276001508 active site 885276001509 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 885276001510 catalytic triad [active] 885276001511 dimer interface [polypeptide binding]; other site 885276001512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 885276001513 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 885276001514 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 885276001515 DNA binding site [nucleotide binding] 885276001516 active site 885276001517 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 885276001518 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 885276001519 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885276001520 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276001521 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 885276001522 maltose O-acetyltransferase; Provisional; Region: PRK10092 885276001523 Maltose acetyltransferase; Region: Mac; pfam12464 885276001524 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 885276001525 trimer interface [polypeptide binding]; other site 885276001526 active site 885276001527 substrate binding site [chemical binding]; other site 885276001528 CoA binding site [chemical binding]; other site 885276001529 gene expression modulator; Provisional; Region: PRK10945 885276001530 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 885276001531 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 885276001532 Protein export membrane protein; Region: SecD_SecF; cl14618 885276001533 Protein export membrane protein; Region: SecD_SecF; cl14618 885276001534 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 885276001535 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276001536 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276001537 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 885276001538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276001539 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 885276001540 hypothetical protein; Provisional; Region: PRK11281 885276001541 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 885276001542 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 885276001543 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885276001544 hypothetical protein; Provisional; Region: PRK11038 885276001545 primosomal replication protein N''; Provisional; Region: PRK10093 885276001546 hypothetical protein; Provisional; Region: PRK10527 885276001547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276001548 active site 885276001549 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 885276001550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276001551 Walker A motif; other site 885276001552 ATP binding site [chemical binding]; other site 885276001553 Walker B motif; other site 885276001554 DNA polymerase III subunit delta'; Validated; Region: PRK08485 885276001555 arginine finger; other site 885276001556 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 885276001557 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 885276001558 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 885276001559 hypothetical protein; Validated; Region: PRK00153 885276001560 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 885276001561 RecR protein; Region: RecR; pfam02132 885276001562 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 885276001563 putative active site [active] 885276001564 putative metal-binding site [ion binding]; other site 885276001565 tetramer interface [polypeptide binding]; other site 885276001566 heat shock protein 90; Provisional; Region: PRK05218 885276001567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276001568 ATP binding site [chemical binding]; other site 885276001569 Mg2+ binding site [ion binding]; other site 885276001570 G-X-G motif; other site 885276001571 adenylate kinase; Reviewed; Region: adk; PRK00279 885276001572 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 885276001573 AMP-binding site [chemical binding]; other site 885276001574 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 885276001575 ferrochelatase; Region: hemH; TIGR00109 885276001576 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 885276001577 C-terminal domain interface [polypeptide binding]; other site 885276001578 active site 885276001579 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 885276001580 active site 885276001581 N-terminal domain interface [polypeptide binding]; other site 885276001582 acetyl esterase; Provisional; Region: PRK10162 885276001583 inosine/guanosine kinase; Provisional; Region: PRK15074 885276001584 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276001585 putative cation:proton antiport protein; Provisional; Region: PRK10669 885276001586 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 885276001587 TrkA-N domain; Region: TrkA_N; pfam02254 885276001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276001589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276001590 putative substrate translocation pore; other site 885276001591 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 885276001592 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 885276001593 active site 885276001594 metal binding site [ion binding]; metal-binding site 885276001595 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885276001596 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 885276001597 putative deacylase active site [active] 885276001598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 885276001599 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 885276001600 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 885276001601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276001602 non-specific DNA binding site [nucleotide binding]; other site 885276001603 salt bridge; other site 885276001604 sequence-specific DNA binding site [nucleotide binding]; other site 885276001605 copper exporting ATPase; Provisional; Region: copA; PRK10671 885276001606 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 885276001607 metal-binding site [ion binding] 885276001608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 885276001609 metal-binding site [ion binding] 885276001610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885276001611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276001612 motif II; other site 885276001613 glutaminase; Reviewed; Region: PRK12356 885276001614 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 885276001615 amino acid transporter; Region: 2A0306; TIGR00909 885276001616 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 885276001617 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 885276001618 DNA binding residues [nucleotide binding] 885276001619 dimer interface [polypeptide binding]; other site 885276001620 copper binding site [ion binding]; other site 885276001621 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 885276001622 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 885276001623 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 885276001624 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 885276001625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276001626 Walker A/P-loop; other site 885276001627 ATP binding site [chemical binding]; other site 885276001628 Q-loop/lid; other site 885276001629 ABC transporter signature motif; other site 885276001630 Walker B; other site 885276001631 D-loop; other site 885276001632 H-loop/switch region; other site 885276001633 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 885276001634 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 885276001635 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 885276001636 oxidoreductase; Provisional; Region: PRK08017 885276001637 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 885276001638 NADP binding site [chemical binding]; other site 885276001639 active site 885276001640 steroid binding site; other site 885276001641 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 885276001642 active site 885276001643 catalytic triad [active] 885276001644 oxyanion hole [active] 885276001645 switch loop; other site 885276001646 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 885276001647 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885276001648 Walker A/P-loop; other site 885276001649 ATP binding site [chemical binding]; other site 885276001650 Q-loop/lid; other site 885276001651 ABC transporter signature motif; other site 885276001652 Walker B; other site 885276001653 D-loop; other site 885276001654 H-loop/switch region; other site 885276001655 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 885276001656 FtsX-like permease family; Region: FtsX; pfam02687 885276001657 FtsX-like permease family; Region: FtsX; pfam02687 885276001658 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 885276001659 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 885276001660 active site residue [active] 885276001661 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 885276001662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276001663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276001664 dimerization interface [polypeptide binding]; other site 885276001665 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 885276001666 ureidoglycolate hydrolase; Provisional; Region: PRK03606 885276001667 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 885276001668 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885276001669 Bacterial transcriptional regulator; Region: IclR; pfam01614 885276001670 glyoxylate carboligase; Provisional; Region: PRK11269 885276001671 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885276001672 PYR/PP interface [polypeptide binding]; other site 885276001673 dimer interface [polypeptide binding]; other site 885276001674 TPP binding site [chemical binding]; other site 885276001675 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885276001676 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 885276001677 TPP-binding site [chemical binding]; other site 885276001678 hydroxypyruvate isomerase; Provisional; Region: PRK09997 885276001679 tartronate semialdehyde reductase; Provisional; Region: PRK15059 885276001680 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885276001681 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 885276001682 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 885276001683 Na binding site [ion binding]; other site 885276001684 substrate binding site [chemical binding]; other site 885276001685 allantoinase; Provisional; Region: PRK08044 885276001686 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 885276001687 active site 885276001688 putative uracil/xanthine transporter; Provisional; Region: PRK11412 885276001689 glycerate kinase II; Provisional; Region: PRK09932 885276001690 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 885276001691 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 885276001692 Cupin domain; Region: Cupin_2; cl17218 885276001693 allantoate amidohydrolase; Region: AllC; TIGR03176 885276001694 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 885276001695 active site 885276001696 metal binding site [ion binding]; metal-binding site 885276001697 dimer interface [polypeptide binding]; other site 885276001698 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 885276001699 membrane protein FdrA; Validated; Region: PRK06091 885276001700 CoA binding domain; Region: CoA_binding; pfam02629 885276001701 CoA-ligase; Region: Ligase_CoA; pfam00549 885276001702 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 885276001703 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 885276001704 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 885276001705 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885276001706 putative substrate binding site [chemical binding]; other site 885276001707 nucleotide binding site [chemical binding]; other site 885276001708 nucleotide binding site [chemical binding]; other site 885276001709 homodimer interface [polypeptide binding]; other site 885276001710 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 885276001711 ATP-grasp domain; Region: ATP-grasp; pfam02222 885276001712 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 885276001713 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 885276001714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885276001715 putative active site [active] 885276001716 putative metal binding site [ion binding]; other site 885276001717 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 885276001718 substrate binding site [chemical binding]; other site 885276001719 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 885276001720 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 885276001721 active site 885276001722 HIGH motif; other site 885276001723 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 885276001724 KMSKS motif; other site 885276001725 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 885276001726 tRNA binding surface [nucleotide binding]; other site 885276001727 anticodon binding site; other site 885276001728 ribosome-associated protein; Provisional; Region: PRK11507 885276001729 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 885276001730 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 885276001731 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 885276001732 homodimer interface [polypeptide binding]; other site 885276001733 NADP binding site [chemical binding]; other site 885276001734 substrate binding site [chemical binding]; other site 885276001735 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276001736 DNA binding site [nucleotide binding] 885276001737 active site 885276001738 Int/Topo IB signature motif; other site 885276001739 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276001740 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 885276001741 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885276001742 S-adenosylmethionine binding site [chemical binding]; other site 885276001743 outer membrane protease; Reviewed; Region: PRK10993 885276001744 hypothetical protein; Provisional; Region: PRK09936 885276001745 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 885276001746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276001747 TPR motif; other site 885276001748 binding surface 885276001749 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 885276001750 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 885276001751 active site 885276001752 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 885276001753 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 885276001754 sensor kinase CusS; Provisional; Region: PRK09835 885276001755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276001756 dimerization interface [polypeptide binding]; other site 885276001757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276001758 dimer interface [polypeptide binding]; other site 885276001759 phosphorylation site [posttranslational modification] 885276001760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276001761 ATP binding site [chemical binding]; other site 885276001762 Mg2+ binding site [ion binding]; other site 885276001763 G-X-G motif; other site 885276001764 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 885276001765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276001766 active site 885276001767 phosphorylation site [posttranslational modification] 885276001768 intermolecular recognition site; other site 885276001769 dimerization interface [polypeptide binding]; other site 885276001770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276001771 DNA binding site [nucleotide binding] 885276001772 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 885276001773 periplasmic copper-binding protein; Provisional; Region: PRK09838 885276001774 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 885276001775 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276001776 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 885276001777 phenylalanine transporter; Provisional; Region: PRK10249 885276001778 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 885276001779 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885276001780 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 885276001781 dimer interface [polypeptide binding]; other site 885276001782 FMN binding site [chemical binding]; other site 885276001783 hypothetical protein; Provisional; Region: PRK10250 885276001784 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 885276001785 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 885276001786 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 885276001787 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 885276001788 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 885276001789 outer membrane receptor FepA; Provisional; Region: PRK13524 885276001790 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276001791 N-terminal plug; other site 885276001792 ligand-binding site [chemical binding]; other site 885276001793 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 885276001794 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 885276001795 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885276001796 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 885276001797 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885276001798 acyl-activating enzyme (AAE) consensus motif; other site 885276001799 AMP binding site [chemical binding]; other site 885276001800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276001801 LPS O-antigen length regulator; Provisional; Region: PRK10381 885276001802 Chain length determinant protein; Region: Wzz; pfam02706 885276001803 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 885276001804 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276001805 Walker A/P-loop; other site 885276001806 ATP binding site [chemical binding]; other site 885276001807 Q-loop/lid; other site 885276001808 ABC transporter signature motif; other site 885276001809 Walker B; other site 885276001810 D-loop; other site 885276001811 H-loop/switch region; other site 885276001812 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 885276001813 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276001814 ABC-ATPase subunit interface; other site 885276001815 dimer interface [polypeptide binding]; other site 885276001816 putative PBP binding regions; other site 885276001817 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885276001818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276001819 ABC-ATPase subunit interface; other site 885276001820 dimer interface [polypeptide binding]; other site 885276001821 putative PBP binding regions; other site 885276001822 enterobactin exporter EntS; Provisional; Region: PRK10489 885276001823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276001824 putative substrate translocation pore; other site 885276001825 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 885276001826 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 885276001827 siderophore binding site; other site 885276001828 isochorismate synthase EntC; Provisional; Region: PRK15016 885276001829 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 885276001830 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 885276001831 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 885276001832 acyl-activating enzyme (AAE) consensus motif; other site 885276001833 active site 885276001834 AMP binding site [chemical binding]; other site 885276001835 substrate binding site [chemical binding]; other site 885276001836 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 885276001837 hydrophobic substrate binding pocket; other site 885276001838 Isochorismatase family; Region: Isochorismatase; pfam00857 885276001839 active site 885276001840 conserved cis-peptide bond; other site 885276001841 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 885276001842 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 885276001843 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 885276001844 putative NAD(P) binding site [chemical binding]; other site 885276001845 active site 885276001846 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 885276001847 CoenzymeA binding site [chemical binding]; other site 885276001848 subunit interaction site [polypeptide binding]; other site 885276001849 PHB binding site; other site 885276001850 carbon starvation protein A; Provisional; Region: PRK15015 885276001851 Carbon starvation protein CstA; Region: CstA; pfam02554 885276001852 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 885276001853 Uncharacterized small protein [Function unknown]; Region: COG2879 885276001854 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 885276001855 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 885276001856 putative active site [active] 885276001857 metal binding site [ion binding]; metal-binding site 885276001858 methionine aminotransferase; Validated; Region: PRK09082 885276001859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276001860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276001861 homodimer interface [polypeptide binding]; other site 885276001862 catalytic residue [active] 885276001863 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 885276001864 ParB-like nuclease domain; Region: ParBc; pfam02195 885276001865 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 885276001866 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885276001867 Active Sites [active] 885276001868 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 885276001869 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 885276001870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276001871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276001872 dimerization interface [polypeptide binding]; other site 885276001873 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 885276001874 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 885276001875 dimerization domain [polypeptide binding]; other site 885276001876 dimer interface [polypeptide binding]; other site 885276001877 catalytic residues [active] 885276001878 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 885276001879 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 885276001880 dimer interface [polypeptide binding]; other site 885276001881 decamer (pentamer of dimers) interface [polypeptide binding]; other site 885276001882 catalytic triad [active] 885276001883 peroxidatic and resolving cysteines [active] 885276001884 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 885276001885 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 885276001886 catalytic residue [active] 885276001887 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 885276001888 catalytic residues [active] 885276001889 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276001890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276001891 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276001892 Ligand Binding Site [chemical binding]; other site 885276001893 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 885276001894 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 885276001895 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 885276001896 B1 nucleotide binding pocket [chemical binding]; other site 885276001897 B2 nucleotide binding pocket [chemical binding]; other site 885276001898 CAS motifs; other site 885276001899 active site 885276001900 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276001901 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885276001902 transmembrane helices; other site 885276001903 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 885276001904 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 885276001905 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 885276001906 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 885276001907 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 885276001908 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 885276001909 putative active site [active] 885276001910 (T/H)XGH motif; other site 885276001911 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 885276001912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276001913 putative active site [active] 885276001914 heme pocket [chemical binding]; other site 885276001915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276001916 ATP binding site [chemical binding]; other site 885276001917 Mg2+ binding site [ion binding]; other site 885276001918 G-X-G motif; other site 885276001919 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 885276001920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276001921 active site 885276001922 phosphorylation site [posttranslational modification] 885276001923 intermolecular recognition site; other site 885276001924 dimerization interface [polypeptide binding]; other site 885276001925 Transcriptional regulator; Region: CitT; pfam12431 885276001926 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 885276001927 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 885276001928 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 885276001929 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885276001930 DNA-binding site [nucleotide binding]; DNA binding site 885276001931 RNA-binding motif; other site 885276001932 chromosome condensation membrane protein; Provisional; Region: PRK14196 885276001933 Predicted amidohydrolase [General function prediction only]; Region: COG0388 885276001934 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 885276001935 putative active site [active] 885276001936 catalytic triad [active] 885276001937 putative dimer interface [polypeptide binding]; other site 885276001938 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 885276001939 lipoyl synthase; Provisional; Region: PRK05481 885276001940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276001941 FeS/SAM binding site; other site 885276001942 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 885276001943 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 885276001944 lipoate-protein ligase B; Provisional; Region: PRK14342 885276001945 hypothetical protein; Provisional; Region: PRK04998 885276001946 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 885276001947 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 885276001948 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 885276001949 rare lipoprotein A; Provisional; Region: PRK10672 885276001950 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 885276001951 Sporulation related domain; Region: SPOR; pfam05036 885276001952 cell wall shape-determining protein; Provisional; Region: PRK10794 885276001953 penicillin-binding protein 2; Provisional; Region: PRK10795 885276001954 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 885276001955 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 885276001956 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 885276001957 ribosome-associated protein; Provisional; Region: PRK11538 885276001958 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885276001959 catalytic core [active] 885276001960 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 885276001961 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 885276001962 active site 885276001963 (T/H)XGH motif; other site 885276001964 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 885276001965 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 885276001966 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 885276001967 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 885276001968 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 885276001969 HIGH motif; other site 885276001970 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 885276001971 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 885276001972 active site 885276001973 KMSKS motif; other site 885276001974 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 885276001975 tRNA binding surface [nucleotide binding]; other site 885276001976 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 885276001977 hypothetical protein; Provisional; Region: PRK11032 885276001978 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 885276001979 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 885276001980 active site 885276001981 tetramer interface [polypeptide binding]; other site 885276001982 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 885276001983 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885276001984 Walker A/P-loop; other site 885276001985 ATP binding site [chemical binding]; other site 885276001986 Q-loop/lid; other site 885276001987 ABC transporter signature motif; other site 885276001988 Walker B; other site 885276001989 D-loop; other site 885276001990 H-loop/switch region; other site 885276001991 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276001992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276001993 dimer interface [polypeptide binding]; other site 885276001994 conserved gate region; other site 885276001995 putative PBP binding loops; other site 885276001996 ABC-ATPase subunit interface; other site 885276001997 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276001998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276001999 dimer interface [polypeptide binding]; other site 885276002000 conserved gate region; other site 885276002001 putative PBP binding loops; other site 885276002002 ABC-ATPase subunit interface; other site 885276002003 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 885276002004 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276002005 substrate binding pocket [chemical binding]; other site 885276002006 membrane-bound complex binding site; other site 885276002007 hinge residues; other site 885276002008 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 885276002009 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 885276002010 Uncharacterized conserved protein [Function unknown]; Region: COG3391 885276002011 structural tetrad; other site 885276002012 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 885276002013 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 885276002014 putative active site [active] 885276002015 catalytic triad [active] 885276002016 putative dimer interface [polypeptide binding]; other site 885276002017 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 885276002018 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885276002019 Transporter associated domain; Region: CorC_HlyC; smart01091 885276002020 metal-binding heat shock protein; Provisional; Region: PRK00016 885276002021 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 885276002022 PhoH-like protein; Region: PhoH; pfam02562 885276002023 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 885276002024 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 885276002025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276002026 FeS/SAM binding site; other site 885276002027 TRAM domain; Region: TRAM; pfam01938 885276002028 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 885276002029 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 885276002030 asparagine synthetase B; Provisional; Region: asnB; PRK09431 885276002031 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 885276002032 active site 885276002033 dimer interface [polypeptide binding]; other site 885276002034 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 885276002035 Ligand Binding Site [chemical binding]; other site 885276002036 Molecular Tunnel; other site 885276002037 UMP phosphatase; Provisional; Region: PRK10444 885276002038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002039 active site 885276002040 motif I; other site 885276002041 motif II; other site 885276002042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002043 MarR family; Region: MarR; pfam01047 885276002044 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 885276002045 ROK family; Region: ROK; pfam00480 885276002046 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 885276002047 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 885276002048 active site 885276002049 dimer interface [polypeptide binding]; other site 885276002050 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 885276002051 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 885276002052 active site 885276002053 trimer interface [polypeptide binding]; other site 885276002054 allosteric site; other site 885276002055 active site lid [active] 885276002056 hexamer (dimer of trimers) interface [polypeptide binding]; other site 885276002057 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 885276002058 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276002059 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276002060 active site turn [active] 885276002061 phosphorylation site [posttranslational modification] 885276002062 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 885276002063 HPr interaction site; other site 885276002064 glycerol kinase (GK) interaction site [polypeptide binding]; other site 885276002065 active site 885276002066 phosphorylation site [posttranslational modification] 885276002067 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 885276002068 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 885276002069 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276002070 transmembrane helices; other site 885276002071 Domain of unknown function (DUF386); Region: DUF386; cl01047 885276002072 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 885276002073 BNR repeat-like domain; Region: BNR_2; pfam13088 885276002074 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885276002075 dihydrodipicolinate synthase; Region: dapA; TIGR00674 885276002076 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 885276002077 inhibitor site; inhibition site 885276002078 active site 885276002079 dimer interface [polypeptide binding]; other site 885276002080 catalytic residue [active] 885276002081 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 885276002082 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 885276002083 putative active site [active] 885276002084 metal binding site [ion binding]; metal-binding site 885276002085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 885276002086 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 885276002087 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 885276002088 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276002089 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276002090 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276002091 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 885276002092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 885276002093 active site 885276002094 HIGH motif; other site 885276002095 nucleotide binding site [chemical binding]; other site 885276002096 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 885276002097 KMSKS motif; other site 885276002098 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 885276002099 outer membrane porin, OprD family; Region: OprD; pfam03573 885276002100 YbfN-like lipoprotein; Region: YbfN; pfam13982 885276002101 ferric uptake regulator; Provisional; Region: fur; PRK09462 885276002102 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 885276002103 metal binding site 2 [ion binding]; metal-binding site 885276002104 putative DNA binding helix; other site 885276002105 metal binding site 1 [ion binding]; metal-binding site 885276002106 dimer interface [polypeptide binding]; other site 885276002107 structural Zn2+ binding site [ion binding]; other site 885276002108 flavodoxin FldA; Validated; Region: PRK09267 885276002109 LexA regulated protein; Provisional; Region: PRK11675 885276002110 acyl-CoA esterase; Provisional; Region: PRK10673 885276002111 PGAP1-like protein; Region: PGAP1; pfam07819 885276002112 replication initiation regulator SeqA; Provisional; Region: PRK11187 885276002113 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 885276002114 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 885276002115 active site 885276002116 substrate binding site [chemical binding]; other site 885276002117 metal binding site [ion binding]; metal-binding site 885276002118 putrescine transporter; Provisional; Region: potE; PRK10655 885276002119 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 885276002120 ornithine decarboxylase; Provisional; Region: PRK13578 885276002121 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885276002122 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885276002123 homodimer interface [polypeptide binding]; other site 885276002124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276002125 catalytic residue [active] 885276002126 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885276002127 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 885276002128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276002129 active site 885276002130 phosphorylation site [posttranslational modification] 885276002131 intermolecular recognition site; other site 885276002132 dimerization interface [polypeptide binding]; other site 885276002133 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276002134 DNA binding site [nucleotide binding] 885276002135 sensor protein KdpD; Provisional; Region: PRK10490 885276002136 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 885276002137 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 885276002138 Ligand Binding Site [chemical binding]; other site 885276002139 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 885276002140 GAF domain; Region: GAF_3; pfam13492 885276002141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276002142 dimer interface [polypeptide binding]; other site 885276002143 phosphorylation site [posttranslational modification] 885276002144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276002145 ATP binding site [chemical binding]; other site 885276002146 Mg2+ binding site [ion binding]; other site 885276002147 G-X-G motif; other site 885276002148 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 885276002149 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 885276002150 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885276002151 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 885276002152 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 885276002153 hypothetical protein; Provisional; Region: PRK10167 885276002154 Uncharacterized conserved protein [Function unknown]; Region: COG3272 885276002155 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 885276002156 DNA photolyase; Region: DNA_photolyase; pfam00875 885276002157 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 885276002158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276002159 putative substrate translocation pore; other site 885276002160 POT family; Region: PTR2; pfam00854 885276002161 Uncharacterized conserved protein [Function unknown]; Region: COG0327 885276002162 metal-binding protein; Provisional; Region: PRK10799 885276002163 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 885276002164 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 885276002165 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 885276002166 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 885276002167 putative active site [active] 885276002168 endonuclease VIII; Provisional; Region: PRK10445 885276002169 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 885276002170 DNA binding site [nucleotide binding] 885276002171 catalytic residue [active] 885276002172 putative catalytic residues [active] 885276002173 H2TH interface [polypeptide binding]; other site 885276002174 intercalation triad [nucleotide binding]; other site 885276002175 substrate specificity determining residue; other site 885276002176 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 885276002177 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 885276002178 Putative ammonia monooxygenase; Region: AmoA; pfam05145 885276002179 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 885276002180 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 885276002181 Fimbrial protein; Region: Fimbrial; cl01416 885276002182 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 885276002183 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 885276002184 dimer interface [polypeptide binding]; other site 885276002185 active site 885276002186 citrylCoA binding site [chemical binding]; other site 885276002187 NADH binding [chemical binding]; other site 885276002188 cationic pore residues; other site 885276002189 oxalacetate/citrate binding site [chemical binding]; other site 885276002190 coenzyme A binding site [chemical binding]; other site 885276002191 catalytic triad [active] 885276002192 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 885276002193 Iron-sulfur protein interface; other site 885276002194 proximal quinone binding site [chemical binding]; other site 885276002195 SdhD (CybS) interface [polypeptide binding]; other site 885276002196 proximal heme binding site [chemical binding]; other site 885276002197 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 885276002198 SdhC subunit interface [polypeptide binding]; other site 885276002199 proximal heme binding site [chemical binding]; other site 885276002200 cardiolipin binding site; other site 885276002201 Iron-sulfur protein interface; other site 885276002202 proximal quinone binding site [chemical binding]; other site 885276002203 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 885276002204 L-aspartate oxidase; Provisional; Region: PRK06175 885276002205 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 885276002206 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 885276002207 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 885276002208 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 885276002209 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 885276002210 TPP-binding site [chemical binding]; other site 885276002211 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 885276002212 dimer interface [polypeptide binding]; other site 885276002213 PYR/PP interface [polypeptide binding]; other site 885276002214 TPP binding site [chemical binding]; other site 885276002215 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 885276002216 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885276002217 E3 interaction surface; other site 885276002218 lipoyl attachment site [posttranslational modification]; other site 885276002219 e3 binding domain; Region: E3_binding; pfam02817 885276002220 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 885276002221 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 885276002222 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 885276002223 CoA-ligase; Region: Ligase_CoA; pfam00549 885276002224 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 885276002225 CoA binding domain; Region: CoA_binding; smart00881 885276002226 CoA-ligase; Region: Ligase_CoA; pfam00549 885276002227 TPR repeat; Region: TPR_11; pfam13414 885276002228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276002229 binding surface 885276002230 TPR motif; other site 885276002231 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 885276002232 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 885276002233 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 885276002234 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 885276002235 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 885276002236 hypothetical protein; Provisional; Region: PRK10588 885276002237 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 885276002238 active site 885276002239 colicin uptake protein TolQ; Provisional; Region: PRK10801 885276002240 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 885276002241 colicin uptake protein TolR; Provisional; Region: PRK11024 885276002242 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 885276002243 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 885276002244 TolA C-terminal; Region: TolA; pfam06519 885276002245 translocation protein TolB; Provisional; Region: tolB; PRK03629 885276002246 TolB amino-terminal domain; Region: TolB_N; pfam04052 885276002247 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 885276002248 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 885276002249 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 885276002250 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 885276002251 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276002252 ligand binding site [chemical binding]; other site 885276002253 tol-pal system protein YbgF; Provisional; Region: PRK10803 885276002254 Tetratricopeptide repeat; Region: TPR_6; pfam13174 885276002255 Tetratricopeptide repeat; Region: TPR_6; pfam13174 885276002256 quinolinate synthetase; Provisional; Region: PRK09375 885276002257 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 885276002258 Cation efflux family; Region: Cation_efflux; cl00316 885276002259 YbgS-like protein; Region: YbgS; pfam13985 885276002260 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 885276002261 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885276002262 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885276002263 catalytic core [active] 885276002264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885276002265 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 885276002266 active site 885276002267 catalytic residues [active] 885276002268 galactokinase; Provisional; Region: PRK05101 885276002269 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 885276002270 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 885276002271 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 885276002272 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 885276002273 dimer interface [polypeptide binding]; other site 885276002274 active site 885276002275 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 885276002276 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 885276002277 NAD binding site [chemical binding]; other site 885276002278 homodimer interface [polypeptide binding]; other site 885276002279 active site 885276002280 substrate binding site [chemical binding]; other site 885276002281 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 885276002282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 885276002283 Walker A/P-loop; other site 885276002284 ATP binding site [chemical binding]; other site 885276002285 Q-loop/lid; other site 885276002286 ABC transporter signature motif; other site 885276002287 Walker B; other site 885276002288 D-loop; other site 885276002289 H-loop/switch region; other site 885276002290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276002291 Walker A/P-loop; other site 885276002292 ATP binding site [chemical binding]; other site 885276002293 Q-loop/lid; other site 885276002294 ABC transporter signature motif; other site 885276002295 Walker B; other site 885276002296 D-loop; other site 885276002297 H-loop/switch region; other site 885276002298 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 885276002299 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 885276002300 molybdenum-pterin binding domain; Region: Mop; TIGR00638 885276002301 TOBE domain; Region: TOBE; pfam03459 885276002302 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 885276002303 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 885276002304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276002305 substrate binding pocket [chemical binding]; other site 885276002306 membrane-bound complex binding site; other site 885276002307 hinge residues; other site 885276002308 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 885276002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002310 dimer interface [polypeptide binding]; other site 885276002311 conserved gate region; other site 885276002312 putative PBP binding loops; other site 885276002313 ABC-ATPase subunit interface; other site 885276002314 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 885276002315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276002316 Walker A/P-loop; other site 885276002317 ATP binding site [chemical binding]; other site 885276002318 Q-loop/lid; other site 885276002319 ABC transporter signature motif; other site 885276002320 Walker B; other site 885276002321 D-loop; other site 885276002322 H-loop/switch region; other site 885276002323 molybdenum-pterin binding domain; Region: Mop; TIGR00638 885276002324 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 885276002325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002326 motif II; other site 885276002327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002328 6-phosphogluconolactonase; Provisional; Region: PRK11028 885276002329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276002330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276002331 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 885276002332 putative dimerization interface [polypeptide binding]; other site 885276002333 PrpF protein; Region: PrpF; pfam04303 885276002334 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276002335 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885276002336 transmembrane helices; other site 885276002337 putative hydratase; Provisional; Region: PRK11413 885276002338 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 885276002339 substrate binding site [chemical binding]; other site 885276002340 ligand binding site [chemical binding]; other site 885276002341 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 885276002342 substrate binding site [chemical binding]; other site 885276002343 acyl-CoA thioesterase; Provisional; Region: PRK10531 885276002344 putative pectinesterase; Region: PLN02432; cl01911 885276002345 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 885276002346 substrate binding site [chemical binding]; other site 885276002347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 885276002348 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 885276002349 Probable transposase; Region: OrfB_IS605; pfam01385 885276002350 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 885276002351 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 885276002352 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885276002353 inhibitor-cofactor binding pocket; inhibition site 885276002354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276002355 catalytic residue [active] 885276002356 biotin synthase; Provisional; Region: PRK15108 885276002357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276002358 FeS/SAM binding site; other site 885276002359 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 885276002360 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 885276002361 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 885276002362 substrate-cofactor binding pocket; other site 885276002363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276002364 catalytic residue [active] 885276002365 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 885276002366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276002367 S-adenosylmethionine binding site [chemical binding]; other site 885276002368 AAA domain; Region: AAA_26; pfam13500 885276002369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885276002370 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 885276002371 ADP binding site [chemical binding]; other site 885276002372 excinuclease ABC subunit B; Provisional; Region: PRK05298 885276002373 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276002374 ATP binding site [chemical binding]; other site 885276002375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276002376 nucleotide binding region [chemical binding]; other site 885276002377 ATP-binding site [chemical binding]; other site 885276002378 Ultra-violet resistance protein B; Region: UvrB; pfam12344 885276002379 UvrB/uvrC motif; Region: UVR; pfam02151 885276002380 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 885276002381 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 885276002382 putative substrate binding pocket [chemical binding]; other site 885276002383 dimer interface [polypeptide binding]; other site 885276002384 phosphate binding site [ion binding]; other site 885276002385 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 885276002386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276002387 FeS/SAM binding site; other site 885276002388 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 885276002389 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 885276002390 MPT binding site; other site 885276002391 trimer interface [polypeptide binding]; other site 885276002392 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 885276002393 trimer interface [polypeptide binding]; other site 885276002394 dimer interface [polypeptide binding]; other site 885276002395 putative active site [active] 885276002396 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 885276002397 MoaE interaction surface [polypeptide binding]; other site 885276002398 MoeB interaction surface [polypeptide binding]; other site 885276002399 thiocarboxylated glycine; other site 885276002400 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 885276002401 MoaE homodimer interface [polypeptide binding]; other site 885276002402 MoaD interaction [polypeptide binding]; other site 885276002403 active site residues [active] 885276002404 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 885276002405 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 885276002406 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 885276002407 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 885276002408 Predicted integral membrane protein [Function unknown]; Region: COG0392 885276002409 cardiolipin synthase 2; Provisional; Region: PRK11263 885276002410 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 885276002411 putative active site [active] 885276002412 catalytic site [active] 885276002413 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 885276002414 putative active site [active] 885276002415 catalytic site [active] 885276002416 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 885276002417 putative catalytic site [active] 885276002418 putative metal binding site [ion binding]; other site 885276002419 putative phosphate binding site [ion binding]; other site 885276002420 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 885276002421 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885276002422 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 885276002423 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885276002424 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 885276002425 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 885276002426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885276002427 Walker A/P-loop; other site 885276002428 ATP binding site [chemical binding]; other site 885276002429 Q-loop/lid; other site 885276002430 ABC transporter signature motif; other site 885276002431 Walker B; other site 885276002432 D-loop; other site 885276002433 H-loop/switch region; other site 885276002434 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 885276002435 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885276002436 Walker A/P-loop; other site 885276002437 ATP binding site [chemical binding]; other site 885276002438 Q-loop/lid; other site 885276002439 ABC transporter signature motif; other site 885276002440 Walker B; other site 885276002441 D-loop; other site 885276002442 H-loop/switch region; other site 885276002443 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 885276002444 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276002445 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276002446 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 885276002447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276002448 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 885276002449 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 885276002450 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885276002451 ATP binding site [chemical binding]; other site 885276002452 Mg++ binding site [ion binding]; other site 885276002453 motif III; other site 885276002454 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276002455 nucleotide binding region [chemical binding]; other site 885276002456 ATP-binding site [chemical binding]; other site 885276002457 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 885276002458 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 885276002459 DEAD_2; Region: DEAD_2; pfam06733 885276002460 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 885276002461 glycosyl transferase family protein; Provisional; Region: PRK08136 885276002462 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 885276002463 putative dehydrogenase; Provisional; Region: PRK10098 885276002464 hypothetical protein; Provisional; Region: PRK10259 885276002465 hypothetical protein; Provisional; Region: PRK11019 885276002466 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 885276002467 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 885276002468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276002469 N-terminal plug; other site 885276002470 ligand-binding site [chemical binding]; other site 885276002471 hypothetical protein; Provisional; Region: PRK10259 885276002472 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 885276002473 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 885276002474 putative mechanosensitive channel protein; Provisional; Region: PRK11465 885276002475 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885276002476 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 885276002477 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885276002478 Walker A/P-loop; other site 885276002479 ATP binding site [chemical binding]; other site 885276002480 Q-loop/lid; other site 885276002481 ABC transporter signature motif; other site 885276002482 Walker B; other site 885276002483 D-loop; other site 885276002484 H-loop/switch region; other site 885276002485 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276002486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002487 dimer interface [polypeptide binding]; other site 885276002488 conserved gate region; other site 885276002489 putative PBP binding loops; other site 885276002490 ABC-ATPase subunit interface; other site 885276002491 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 885276002492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276002493 substrate binding pocket [chemical binding]; other site 885276002494 membrane-bound complex binding site; other site 885276002495 hinge residues; other site 885276002496 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 885276002497 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 885276002498 dimerization interface [polypeptide binding]; other site 885276002499 DPS ferroxidase diiron center [ion binding]; other site 885276002500 ion pore; other site 885276002501 threonine and homoserine efflux system; Provisional; Region: PRK10532 885276002502 EamA-like transporter family; Region: EamA; pfam00892 885276002503 outer membrane protein X; Provisional; Region: ompX; PRK09408 885276002504 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 885276002505 Sulfatase; Region: Sulfatase; pfam00884 885276002506 manganese transport regulator MntR; Provisional; Region: PRK11050 885276002507 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 885276002508 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 885276002509 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276002510 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 885276002511 transmembrane helices; other site 885276002512 L,D-transpeptidase; Provisional; Region: PRK10260 885276002513 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276002514 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 885276002515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276002516 Walker A/P-loop; other site 885276002517 ATP binding site [chemical binding]; other site 885276002518 Q-loop/lid; other site 885276002519 ABC transporter signature motif; other site 885276002520 Walker B; other site 885276002521 D-loop; other site 885276002522 H-loop/switch region; other site 885276002523 ABC transporter; Region: ABC_tran_2; pfam12848 885276002524 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885276002525 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 885276002526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002527 active site 885276002528 motif I; other site 885276002529 motif II; other site 885276002530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002531 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 885276002532 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 885276002533 dimer interface [polypeptide binding]; other site 885276002534 active site 885276002535 glycine loop; other site 885276002536 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 885276002537 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 885276002538 active site 885276002539 intersubunit interactions; other site 885276002540 catalytic residue [active] 885276002541 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 885276002542 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 885276002543 ATP binding site [chemical binding]; other site 885276002544 substrate interface [chemical binding]; other site 885276002545 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 885276002546 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 885276002547 dimer interface [polypeptide binding]; other site 885276002548 putative functional site; other site 885276002549 putative MPT binding site; other site 885276002550 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 885276002551 catalytic nucleophile [active] 885276002552 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 885276002553 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276002554 Walker A/P-loop; other site 885276002555 ATP binding site [chemical binding]; other site 885276002556 Q-loop/lid; other site 885276002557 ABC transporter signature motif; other site 885276002558 Walker B; other site 885276002559 D-loop; other site 885276002560 H-loop/switch region; other site 885276002561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885276002562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276002563 Walker A/P-loop; other site 885276002564 ATP binding site [chemical binding]; other site 885276002565 Q-loop/lid; other site 885276002566 ABC transporter signature motif; other site 885276002567 Walker B; other site 885276002568 D-loop; other site 885276002569 H-loop/switch region; other site 885276002570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 885276002571 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 885276002572 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 885276002573 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 885276002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002575 dimer interface [polypeptide binding]; other site 885276002576 conserved gate region; other site 885276002577 putative PBP binding loops; other site 885276002578 ABC-ATPase subunit interface; other site 885276002579 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 885276002580 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885276002581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002582 dimer interface [polypeptide binding]; other site 885276002583 conserved gate region; other site 885276002584 putative PBP binding loops; other site 885276002585 ABC-ATPase subunit interface; other site 885276002586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276002587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276002588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276002589 metal binding site [ion binding]; metal-binding site 885276002590 active site 885276002591 I-site; other site 885276002592 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 885276002593 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 885276002594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276002595 FeS/SAM binding site; other site 885276002596 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 885276002597 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 885276002598 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 885276002599 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 885276002600 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 885276002601 putative C-terminal domain interface [polypeptide binding]; other site 885276002602 putative GSH binding site (G-site) [chemical binding]; other site 885276002603 putative dimer interface [polypeptide binding]; other site 885276002604 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 885276002605 N-terminal domain interface [polypeptide binding]; other site 885276002606 dimer interface [polypeptide binding]; other site 885276002607 substrate binding pocket (H-site) [chemical binding]; other site 885276002608 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 885276002609 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 885276002610 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 885276002611 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 885276002612 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276002613 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276002614 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 885276002615 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885276002616 active site 885276002617 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 885276002618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276002619 putative substrate translocation pore; other site 885276002620 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 885276002621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002622 active site 885276002623 motif I; other site 885276002624 motif II; other site 885276002625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276002626 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 885276002627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276002628 putative substrate translocation pore; other site 885276002629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276002630 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 885276002631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276002632 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 885276002633 putative transporter; Provisional; Region: PRK04972 885276002634 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 885276002635 TrkA-C domain; Region: TrkA_C; pfam02080 885276002636 TrkA-C domain; Region: TrkA_C; pfam02080 885276002637 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 885276002638 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 885276002639 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 885276002640 GSH binding site [chemical binding]; other site 885276002641 catalytic residues [active] 885276002642 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 885276002643 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 885276002644 dimer interface [polypeptide binding]; other site 885276002645 FMN binding site [chemical binding]; other site 885276002646 NADPH bind site [chemical binding]; other site 885276002647 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 885276002648 RimK-like ATP-grasp domain; Region: RimK; pfam08443 885276002649 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 885276002650 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 885276002651 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 885276002652 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 885276002653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276002654 Walker A/P-loop; other site 885276002655 ATP binding site [chemical binding]; other site 885276002656 Q-loop/lid; other site 885276002657 ABC transporter signature motif; other site 885276002658 Walker B; other site 885276002659 D-loop; other site 885276002660 H-loop/switch region; other site 885276002661 TOBE domain; Region: TOBE_2; pfam08402 885276002662 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 885276002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002664 dimer interface [polypeptide binding]; other site 885276002665 conserved gate region; other site 885276002666 putative PBP binding loops; other site 885276002667 ABC-ATPase subunit interface; other site 885276002668 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 885276002669 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 885276002670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276002671 S-adenosylmethionine binding site [chemical binding]; other site 885276002672 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 885276002673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276002674 substrate binding pocket [chemical binding]; other site 885276002675 membrane-bound complex binding site; other site 885276002676 hinge residues; other site 885276002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002678 dimer interface [polypeptide binding]; other site 885276002679 conserved gate region; other site 885276002680 putative PBP binding loops; other site 885276002681 ABC-ATPase subunit interface; other site 885276002682 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002684 dimer interface [polypeptide binding]; other site 885276002685 conserved gate region; other site 885276002686 putative PBP binding loops; other site 885276002687 ABC-ATPase subunit interface; other site 885276002688 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 885276002689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276002690 substrate binding pocket [chemical binding]; other site 885276002691 membrane-bound complex binding site; other site 885276002692 hinge residues; other site 885276002693 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 885276002694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276002695 Walker A/P-loop; other site 885276002696 ATP binding site [chemical binding]; other site 885276002697 Q-loop/lid; other site 885276002698 ABC transporter signature motif; other site 885276002699 Walker B; other site 885276002700 D-loop; other site 885276002701 H-loop/switch region; other site 885276002702 putative lipoprotein; Provisional; Region: PRK10533 885276002703 hypothetical protein; Provisional; Region: PRK02877 885276002704 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 885276002705 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 885276002706 amidase catalytic site [active] 885276002707 Zn binding residues [ion binding]; other site 885276002708 substrate binding site [chemical binding]; other site 885276002709 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885276002710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885276002711 NAD(P) binding site [chemical binding]; other site 885276002712 active site 885276002713 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 885276002714 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 885276002715 putative NAD(P) binding site [chemical binding]; other site 885276002716 putative active site [active] 885276002717 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 885276002718 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 885276002719 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 885276002720 tetramer interface [polypeptide binding]; other site 885276002721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276002722 catalytic residue [active] 885276002723 pyruvate dehydrogenase; Provisional; Region: PRK09124 885276002724 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 885276002725 PYR/PP interface [polypeptide binding]; other site 885276002726 dimer interface [polypeptide binding]; other site 885276002727 tetramer interface [polypeptide binding]; other site 885276002728 TPP binding site [chemical binding]; other site 885276002729 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885276002730 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 885276002731 TPP-binding site [chemical binding]; other site 885276002732 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 885276002733 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 885276002734 FAD binding pocket [chemical binding]; other site 885276002735 FAD binding motif [chemical binding]; other site 885276002736 phosphate binding motif [ion binding]; other site 885276002737 beta-alpha-beta structure motif; other site 885276002738 NAD binding pocket [chemical binding]; other site 885276002739 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885276002740 catalytic loop [active] 885276002741 iron binding site [ion binding]; other site 885276002742 hybrid cluster protein; Provisional; Region: PRK05290 885276002743 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276002744 ACS interaction site; other site 885276002745 CODH interaction site; other site 885276002746 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 885276002747 hybrid metal cluster; other site 885276002748 Predicted membrane protein [Function unknown]; Region: COG2431 885276002749 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 885276002750 amphipathic channel; other site 885276002751 Asn-Pro-Ala signature motifs; other site 885276002752 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 885276002753 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 885276002754 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 885276002755 putative active site [active] 885276002756 putative metal-binding site [ion binding]; other site 885276002757 Protein of unknown function (DUF535); Region: DUF535; pfam04393 885276002758 macrolide transporter subunit MacA; Provisional; Region: PRK11578 885276002759 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276002760 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276002761 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 885276002762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885276002763 Walker A/P-loop; other site 885276002764 ATP binding site [chemical binding]; other site 885276002765 Q-loop/lid; other site 885276002766 ABC transporter signature motif; other site 885276002767 Walker B; other site 885276002768 D-loop; other site 885276002769 H-loop/switch region; other site 885276002770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 885276002771 FtsX-like permease family; Region: FtsX; pfam02687 885276002772 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885276002773 DNA-binding site [nucleotide binding]; DNA binding site 885276002774 RNA-binding motif; other site 885276002775 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 885276002776 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 885276002777 Clp amino terminal domain; Region: Clp_N; pfam02861 885276002778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276002779 Walker A motif; other site 885276002780 ATP binding site [chemical binding]; other site 885276002781 Walker B motif; other site 885276002782 arginine finger; other site 885276002783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276002784 Walker A motif; other site 885276002785 ATP binding site [chemical binding]; other site 885276002786 Walker B motif; other site 885276002787 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 885276002788 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 885276002789 rRNA binding site [nucleotide binding]; other site 885276002790 predicted 30S ribosome binding site; other site 885276002791 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 885276002792 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 885276002793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276002794 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 885276002795 Walker A/P-loop; other site 885276002796 ATP binding site [chemical binding]; other site 885276002797 Q-loop/lid; other site 885276002798 ABC transporter signature motif; other site 885276002799 Walker B; other site 885276002800 D-loop; other site 885276002801 H-loop/switch region; other site 885276002802 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 885276002803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276002804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276002805 Walker A/P-loop; other site 885276002806 ATP binding site [chemical binding]; other site 885276002807 Q-loop/lid; other site 885276002808 ABC transporter signature motif; other site 885276002809 Walker B; other site 885276002810 D-loop; other site 885276002811 H-loop/switch region; other site 885276002812 thioredoxin reductase; Provisional; Region: PRK10262 885276002813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276002814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276002815 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 885276002816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276002817 putative DNA binding site [nucleotide binding]; other site 885276002818 putative Zn2+ binding site [ion binding]; other site 885276002819 AsnC family; Region: AsnC_trans_reg; pfam01037 885276002820 DNA translocase FtsK; Provisional; Region: PRK10263 885276002821 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 885276002822 DNA translocase FtsK; Provisional; Region: PRK10263 885276002823 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 885276002824 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 885276002825 periplasmic chaperone LolA; Region: lolA; TIGR00547 885276002826 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 885276002827 recombination factor protein RarA; Reviewed; Region: PRK13342 885276002828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276002829 Walker A motif; other site 885276002830 ATP binding site [chemical binding]; other site 885276002831 Walker B motif; other site 885276002832 arginine finger; other site 885276002833 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 885276002834 seryl-tRNA synthetase; Provisional; Region: PRK05431 885276002835 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 885276002836 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 885276002837 dimer interface [polypeptide binding]; other site 885276002838 active site 885276002839 motif 1; other site 885276002840 motif 2; other site 885276002841 motif 3; other site 885276002842 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 885276002843 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885276002844 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 885276002845 putative [Fe4-S4] binding site [ion binding]; other site 885276002846 putative molybdopterin cofactor binding site [chemical binding]; other site 885276002847 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 885276002848 putative molybdopterin cofactor binding site; other site 885276002849 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 885276002850 4Fe-4S binding domain; Region: Fer4; pfam00037 885276002851 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 885276002852 Isochorismatase family; Region: Isochorismatase; pfam00857 885276002853 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 885276002854 catalytic triad [active] 885276002855 dimer interface [polypeptide binding]; other site 885276002856 conserved cis-peptide bond; other site 885276002857 putative MFS family transporter protein; Provisional; Region: PRK03633 885276002858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276002859 putative substrate translocation pore; other site 885276002860 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 885276002861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276002862 FeS/SAM binding site; other site 885276002863 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 885276002864 Pyruvate formate lyase 1; Region: PFL1; cd01678 885276002865 coenzyme A binding site [chemical binding]; other site 885276002866 active site 885276002867 catalytic residues [active] 885276002868 glycine loop; other site 885276002869 formate transporter; Provisional; Region: PRK10805 885276002870 uncharacterized domain; Region: TIGR00702 885276002871 YcaO-like family; Region: YcaO; pfam02624 885276002872 Predicted membrane protein [Function unknown]; Region: COG2323 885276002873 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 885276002874 homodimer interface [polypeptide binding]; other site 885276002875 substrate-cofactor binding pocket; other site 885276002876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276002877 catalytic residue [active] 885276002878 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 885276002879 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 885276002880 hinge; other site 885276002881 active site 885276002882 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 885276002883 cytidylate kinase; Provisional; Region: cmk; PRK00023 885276002884 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 885276002885 CMP-binding site; other site 885276002886 The sites determining sugar specificity; other site 885276002887 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 885276002888 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 885276002889 RNA binding site [nucleotide binding]; other site 885276002890 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 885276002891 RNA binding site [nucleotide binding]; other site 885276002892 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 885276002893 RNA binding site [nucleotide binding]; other site 885276002894 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 885276002895 RNA binding site [nucleotide binding]; other site 885276002896 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 885276002897 RNA binding site [nucleotide binding]; other site 885276002898 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885276002899 IHF dimer interface [polypeptide binding]; other site 885276002900 IHF - DNA interface [nucleotide binding]; other site 885276002901 ComEC family competence protein; Provisional; Region: PRK11539 885276002902 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 885276002903 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 885276002904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 885276002905 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 885276002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276002907 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 885276002908 Walker A/P-loop; other site 885276002909 ATP binding site [chemical binding]; other site 885276002910 Q-loop/lid; other site 885276002911 ABC transporter signature motif; other site 885276002912 Walker B; other site 885276002913 D-loop; other site 885276002914 H-loop/switch region; other site 885276002915 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 885276002916 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 885276002917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 885276002918 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 885276002919 hypothetical protein; Provisional; Region: PRK11827 885276002920 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 885276002921 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 885276002922 Ligand binding site; other site 885276002923 oligomer interface; other site 885276002924 hypothetical protein; Provisional; Region: PRK10593 885276002925 Uncharacterized conserved protein [Function unknown]; Region: COG1434 885276002926 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885276002927 putative active site [active] 885276002928 Methyltransferase domain; Region: Methyltransf_31; pfam13847 885276002929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276002930 S-adenosylmethionine binding site [chemical binding]; other site 885276002931 condesin subunit F; Provisional; Region: PRK05260 885276002932 condesin subunit E; Provisional; Region: PRK05256 885276002933 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 885276002934 MukB N-terminal; Region: MukB; pfam04310 885276002935 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 885276002936 murein L,D-transpeptidase; Provisional; Region: PRK10594 885276002937 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 885276002938 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276002939 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276002940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 885276002941 Peptidase M15; Region: Peptidase_M15_3; cl01194 885276002942 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 885276002943 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 885276002944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276002945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276002946 homodimer interface [polypeptide binding]; other site 885276002947 catalytic residue [active] 885276002948 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276002949 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276002950 trimer interface [polypeptide binding]; other site 885276002951 eyelet of channel; other site 885276002952 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 885276002953 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 885276002954 putative dimer interface [polypeptide binding]; other site 885276002955 putative anticodon binding site; other site 885276002956 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 885276002957 homodimer interface [polypeptide binding]; other site 885276002958 motif 1; other site 885276002959 motif 2; other site 885276002960 active site 885276002961 motif 3; other site 885276002962 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 885276002963 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 885276002964 active site 885276002965 aminopeptidase N; Provisional; Region: pepN; PRK14015 885276002966 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 885276002967 active site 885276002968 Zn binding site [ion binding]; other site 885276002969 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 885276002970 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 885276002971 Walker A/P-loop; other site 885276002972 ATP binding site [chemical binding]; other site 885276002973 Q-loop/lid; other site 885276002974 ABC transporter signature motif; other site 885276002975 Walker B; other site 885276002976 D-loop; other site 885276002977 H-loop/switch region; other site 885276002978 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 885276002979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276002980 dimer interface [polypeptide binding]; other site 885276002981 conserved gate region; other site 885276002982 putative PBP binding loops; other site 885276002983 ABC-ATPase subunit interface; other site 885276002984 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 885276002985 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 885276002986 active site 885276002987 dimer interface [polypeptide binding]; other site 885276002988 non-prolyl cis peptide bond; other site 885276002989 insertion regions; other site 885276002990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276002991 substrate binding pocket [chemical binding]; other site 885276002992 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 885276002993 membrane-bound complex binding site; other site 885276002994 hinge residues; other site 885276002995 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 885276002996 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885276002997 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 885276002998 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 885276002999 quinone interaction residues [chemical binding]; other site 885276003000 active site 885276003001 catalytic residues [active] 885276003002 FMN binding site [chemical binding]; other site 885276003003 substrate binding site [chemical binding]; other site 885276003004 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 885276003005 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 885276003006 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 885276003007 MOSC domain; Region: MOSC; pfam03473 885276003008 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885276003009 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 885276003010 catalytic loop [active] 885276003011 iron binding site [ion binding]; other site 885276003012 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 885276003013 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 885276003014 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 885276003015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276003016 S-adenosylmethionine binding site [chemical binding]; other site 885276003017 ABC transporter ATPase component; Reviewed; Region: PRK11147 885276003018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276003020 Walker A/P-loop; other site 885276003021 Walker A/P-loop; other site 885276003022 ATP binding site [chemical binding]; other site 885276003023 ATP binding site [chemical binding]; other site 885276003024 Q-loop/lid; other site 885276003025 Q-loop/lid; other site 885276003026 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885276003027 ABC transporter signature motif; other site 885276003028 Walker B; other site 885276003029 D-loop; other site 885276003030 ABC transporter; Region: ABC_tran_2; pfam12848 885276003031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885276003032 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 885276003033 Paraquat-inducible protein A; Region: PqiA; pfam04403 885276003034 Paraquat-inducible protein A; Region: PqiA; pfam04403 885276003035 paraquat-inducible protein B; Provisional; Region: PRK10807 885276003036 mce related protein; Region: MCE; pfam02470 885276003037 mce related protein; Region: MCE; pfam02470 885276003038 mce related protein; Region: MCE; pfam02470 885276003039 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 885276003040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 885276003041 Protein of unknown function (DUF330); Region: DUF330; pfam03886 885276003042 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 885276003043 active site 1 [active] 885276003044 dimer interface [polypeptide binding]; other site 885276003045 active site 2 [active] 885276003046 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 885276003047 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 885276003048 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 885276003049 outer membrane protein A; Reviewed; Region: PRK10808 885276003050 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 885276003051 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276003052 ligand binding site [chemical binding]; other site 885276003053 SOS cell division inhibitor; Provisional; Region: PRK10595 885276003054 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 885276003055 TfoX C-terminal domain; Region: TfoX_C; pfam04994 885276003056 TIGR01666 family membrane protein; Region: YCCS 885276003057 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 885276003058 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885276003059 Predicted membrane protein [Function unknown]; Region: COG3304 885276003060 Domain of unknown function (DUF307); Region: DUF307; pfam03733 885276003061 Domain of unknown function (DUF307); Region: DUF307; pfam03733 885276003062 DNA helicase IV; Provisional; Region: helD; PRK11054 885276003063 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 885276003064 Part of AAA domain; Region: AAA_19; pfam13245 885276003065 Family description; Region: UvrD_C_2; pfam13538 885276003066 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 885276003067 active site 885276003068 dimer interfaces [polypeptide binding]; other site 885276003069 catalytic residues [active] 885276003070 hypothetical protein; Provisional; Region: PRK03641 885276003071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 885276003072 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 885276003073 heat shock protein HspQ; Provisional; Region: PRK14129 885276003074 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 885276003075 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 885276003076 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 885276003077 putative RNA binding site [nucleotide binding]; other site 885276003078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276003079 S-adenosylmethionine binding site [chemical binding]; other site 885276003080 acylphosphatase; Provisional; Region: PRK14439 885276003081 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 885276003082 sulfur transfer protein TusE; Provisional; Region: PRK11508 885276003083 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 885276003084 YccA-like proteins; Region: YccA_like; cd10433 885276003085 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 885276003086 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885276003087 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 885276003088 hydrogenase 1 large subunit; Provisional; Region: PRK10170 885276003089 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 885276003090 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 885276003091 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 885276003092 putative substrate-binding site; other site 885276003093 nickel binding site [ion binding]; other site 885276003094 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 885276003095 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 885276003096 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 885276003097 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 885276003098 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 885276003099 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 885276003100 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 885276003101 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885276003102 catalytic core [active] 885276003103 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885276003104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885276003105 DNA-binding site [nucleotide binding]; DNA binding site 885276003106 RNA-binding motif; other site 885276003107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885276003108 DNA-binding site [nucleotide binding]; DNA binding site 885276003109 RNA-binding motif; other site 885276003110 cold shock gene; Provisional; Region: PRK09891 885276003111 GnsA/GnsB family; Region: GnsAB; pfam08178 885276003112 4Fe-4S binding domain; Region: Fer4_5; pfam12801 885276003113 4Fe-4S binding domain; Region: Fer4_5; pfam12801 885276003114 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 885276003115 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276003116 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 885276003117 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 885276003118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 885276003119 dimerization interface [polypeptide binding]; other site 885276003120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276003121 dimer interface [polypeptide binding]; other site 885276003122 phosphorylation site [posttranslational modification] 885276003123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276003124 ATP binding site [chemical binding]; other site 885276003125 Mg2+ binding site [ion binding]; other site 885276003126 G-X-G motif; other site 885276003127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276003128 active site 885276003129 phosphorylation site [posttranslational modification] 885276003130 intermolecular recognition site; other site 885276003131 dimerization interface [polypeptide binding]; other site 885276003132 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885276003133 putative binding surface; other site 885276003134 active site 885276003135 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 885276003136 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 885276003137 putative ligand binding site [chemical binding]; other site 885276003138 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 885276003139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276003140 active site 885276003141 phosphorylation site [posttranslational modification] 885276003142 intermolecular recognition site; other site 885276003143 dimerization interface [polypeptide binding]; other site 885276003144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276003145 DNA binding site [nucleotide binding] 885276003146 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 885276003147 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 885276003148 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 885276003149 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 885276003150 molybdopterin cofactor binding site [chemical binding]; other site 885276003151 substrate binding site [chemical binding]; other site 885276003152 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 885276003153 molybdopterin cofactor binding site; other site 885276003154 chaperone protein TorD; Validated; Region: torD; PRK04976 885276003155 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 885276003156 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 885276003157 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 885276003158 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885276003159 HSP70 interaction site [polypeptide binding]; other site 885276003160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 885276003161 substrate binding site [polypeptide binding]; other site 885276003162 dimer interface [polypeptide binding]; other site 885276003163 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 885276003164 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885276003165 catalytic core [active] 885276003166 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 885276003167 hypothetical protein; Provisional; Region: PRK10174 885276003168 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 885276003169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885276003170 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 885276003171 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 885276003172 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 885276003173 putative FMN binding site [chemical binding]; other site 885276003174 pyrimidine utilization protein D; Region: RutD; TIGR03611 885276003175 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 885276003176 homotrimer interaction site [polypeptide binding]; other site 885276003177 putative active site [active] 885276003178 Isochorismatase family; Region: Isochorismatase; pfam00857 885276003179 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 885276003180 catalytic triad [active] 885276003181 conserved cis-peptide bond; other site 885276003182 pyrimidine utilization protein A; Region: RutA; TIGR03612 885276003183 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 885276003184 active site 885276003185 dimer interface [polypeptide binding]; other site 885276003186 non-prolyl cis peptide bond; other site 885276003187 insertion regions; other site 885276003188 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 885276003189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276003190 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 885276003191 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 885276003192 Predicted transcriptional regulator [Transcription]; Region: COG3905 885276003193 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 885276003194 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 885276003195 Glutamate binding site [chemical binding]; other site 885276003196 NAD binding site [chemical binding]; other site 885276003197 catalytic residues [active] 885276003198 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 885276003199 Na binding site [ion binding]; other site 885276003200 FTR1 family protein; Region: TIGR00145 885276003201 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 885276003202 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 885276003203 Imelysin; Region: Peptidase_M75; pfam09375 885276003204 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 885276003205 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 885276003206 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 885276003207 hypothetical protein; Provisional; Region: PRK10536 885276003208 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 885276003209 N-glycosyltransferase; Provisional; Region: PRK11204 885276003210 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 885276003211 DXD motif; other site 885276003212 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 885276003213 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 885276003214 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 885276003215 putative active site [active] 885276003216 putative metal binding site [ion binding]; other site 885276003217 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 885276003218 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276003219 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276003220 metal binding site [ion binding]; metal-binding site 885276003221 active site 885276003222 I-site; other site 885276003223 integrase; Provisional; Region: PRK09692 885276003224 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276003225 active site 885276003226 Int/Topo IB signature motif; other site 885276003227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885276003228 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885276003229 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885276003230 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 885276003231 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 885276003232 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276003233 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 885276003234 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 885276003235 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 885276003236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276003238 homodimer interface [polypeptide binding]; other site 885276003239 catalytic residue [active] 885276003240 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 885276003241 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 885276003242 putative active site [active] 885276003243 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 885276003244 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885276003245 dimer interface [polypeptide binding]; other site 885276003246 active site 885276003247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885276003248 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 885276003249 NAD(P) binding site [chemical binding]; other site 885276003250 active site 885276003251 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 885276003252 putative active site 1 [active] 885276003253 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 885276003254 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885276003255 dimer interface [polypeptide binding]; other site 885276003256 active site 885276003257 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 885276003258 Predicted exporter [General function prediction only]; Region: COG4258 885276003259 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 885276003260 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 885276003261 active site 885276003262 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 885276003263 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 885276003264 Putative Catalytic site; other site 885276003265 DXD motif; other site 885276003266 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885276003267 putative acyl-acceptor binding pocket; other site 885276003268 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 885276003269 active site 2 [active] 885276003270 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 885276003271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885276003272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885276003273 acyl-activating enzyme (AAE) consensus motif; other site 885276003274 acyl-activating enzyme (AAE) consensus motif; other site 885276003275 active site 885276003276 AMP binding site [chemical binding]; other site 885276003277 CoA binding site [chemical binding]; other site 885276003278 Predicted membrane protein [Function unknown]; Region: COG4648 885276003279 acyl carrier protein; Provisional; Region: PRK05350 885276003280 Phosphopantetheine attachment site; Region: PP-binding; cl09936 885276003281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 885276003282 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 885276003283 putative acyl-acceptor binding pocket; other site 885276003284 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 885276003285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276003286 S-adenosylmethionine binding site [chemical binding]; other site 885276003287 potential frameshift: common BLAST hit: gi|110644687|ref|YP_672417.1| hemagglutinin-related protein 885276003288 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 885276003289 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885276003290 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 885276003291 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 885276003292 Integrase core domain; Region: rve; pfam00665 885276003293 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 885276003294 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 885276003295 active site 885276003296 substrate binding site [chemical binding]; other site 885276003297 catalytic site [active] 885276003298 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885276003299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885276003300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885276003301 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885276003302 Helix-turn-helix domain; Region: HTH_38; pfam13936 885276003303 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822 885276003304 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885276003305 putative transposase OrfB; Reviewed; Region: PHA02517 885276003306 Integrase core domain; Region: rve; pfam00665 885276003307 Integrase core domain; Region: rve_2; pfam13333 885276003308 RTX toxin acyltransferase family; Region: HlyC; pfam02794 885276003309 HlyD family secretion protein; Region: HlyD; pfam00529 885276003310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276003311 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276003312 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 885276003313 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 885276003314 putative active site [active] 885276003315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276003316 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 885276003317 Walker A/P-loop; other site 885276003318 ATP binding site [chemical binding]; other site 885276003319 Q-loop/lid; other site 885276003320 ABC transporter signature motif; other site 885276003321 Walker B; other site 885276003322 D-loop; other site 885276003323 H-loop/switch region; other site 885276003324 CAAX protease self-immunity; Region: Abi; pfam02517 885276003325 FaeA-like protein; Region: FaeA; pfam04703 885276003326 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 885276003327 Fimbrial protein; Region: Fimbrial; cl01416 885276003328 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276003329 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 885276003330 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276003331 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276003332 outer membrane usher protein; Provisional; Region: PRK15193 885276003333 PapC N-terminal domain; Region: PapC_N; pfam13954 885276003334 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276003335 PapC C-terminal domain; Region: PapC_C; pfam13953 885276003336 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276003337 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276003338 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 885276003339 mannosyl binding site [chemical binding]; other site 885276003340 Fimbrial protein; Region: Fimbrial; pfam00419 885276003341 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276003342 MarR family; Region: MarR_2; cl17246 885276003343 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885276003344 Homeodomain-like domain; Region: HTH_23; pfam13384 885276003345 Winged helix-turn helix; Region: HTH_29; pfam13551 885276003346 Winged helix-turn helix; Region: HTH_33; pfam13592 885276003347 DDE superfamily endonuclease; Region: DDE_3; pfam13358 885276003348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 885276003349 outer membrane receptor FepA; Provisional; Region: PRK13528 885276003350 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276003351 N-terminal plug; other site 885276003352 ligand-binding site [chemical binding]; other site 885276003353 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885276003354 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 885276003355 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 885276003356 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885276003357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276003358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 885276003359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276003360 Walker A/P-loop; other site 885276003361 ATP binding site [chemical binding]; other site 885276003362 Q-loop/lid; other site 885276003363 ABC transporter signature motif; other site 885276003364 Walker B; other site 885276003365 D-loop; other site 885276003366 H-loop/switch region; other site 885276003367 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 885276003368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276003369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276003370 Walker A/P-loop; other site 885276003371 ATP binding site [chemical binding]; other site 885276003372 Q-loop/lid; other site 885276003373 ABC transporter signature motif; other site 885276003374 Walker B; other site 885276003375 D-loop; other site 885276003376 H-loop/switch region; other site 885276003377 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 885276003378 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 885276003379 homodimer interface [polypeptide binding]; other site 885276003380 active site 885276003381 TDP-binding site; other site 885276003382 acceptor substrate-binding pocket; other site 885276003383 Transposase IS200 like; Region: Y1_Tnp; pfam01797 885276003384 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 885276003385 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 885276003386 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 885276003387 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276003388 N-terminal plug; other site 885276003389 ligand-binding site [chemical binding]; other site 885276003390 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 885276003391 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 885276003392 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885276003393 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 885276003394 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 885276003395 Sel1-like repeats; Region: SEL1; smart00671 885276003396 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885276003397 Sel1-like repeats; Region: SEL1; smart00671 885276003398 Sel1-like repeats; Region: SEL1; smart00671 885276003399 Sel1-like repeats; Region: SEL1; smart00671 885276003400 Sel1-like repeats; Region: SEL1; smart00671 885276003401 Sel1-like repeats; Region: SEL1; smart00671 885276003402 Sel1-like repeats; Region: SEL1; smart00671 885276003403 Sel1-like repeats; Region: SEL1; smart00671 885276003404 Sel1-like repeats; Region: SEL1; smart00671 885276003405 HsdM N-terminal domain; Region: HsdM_N; pfam12161 885276003406 Predicted GTPase [General function prediction only]; Region: COG3596 885276003407 YfjP GTPase; Region: YfjP; cd11383 885276003408 G1 box; other site 885276003409 GTP/Mg2+ binding site [chemical binding]; other site 885276003410 Switch I region; other site 885276003411 G2 box; other site 885276003412 Switch II region; other site 885276003413 G3 box; other site 885276003414 G4 box; other site 885276003415 G5 box; other site 885276003416 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885276003417 hypothetical protein; Provisional; Region: PRK09945 885276003418 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885276003419 hypothetical protein; Provisional; Region: PRK09945 885276003420 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885276003421 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276003422 Autotransporter beta-domain; Region: Autotransporter; smart00869 885276003423 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885276003424 Antirestriction protein; Region: Antirestrict; pfam03230 885276003425 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885276003426 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885276003427 MPN+ (JAMM) motif; other site 885276003428 Zinc-binding site [ion binding]; other site 885276003429 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885276003430 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 885276003431 Methyltransferase domain; Region: Methyltransf_27; pfam13708 885276003432 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 885276003433 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 885276003434 putative ligand binding site [chemical binding]; other site 885276003435 NAD binding site [chemical binding]; other site 885276003436 dimerization interface [polypeptide binding]; other site 885276003437 catalytic site [active] 885276003438 putative hydrolase; Validated; Region: PRK09248 885276003439 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 885276003440 active site 885276003441 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 885276003442 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 885276003443 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 885276003444 curli assembly protein CsgF; Provisional; Region: PRK10050 885276003445 curli assembly protein CsgE; Provisional; Region: PRK10386 885276003446 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 885276003447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276003448 DNA binding residues [nucleotide binding] 885276003449 dimerization interface [polypeptide binding]; other site 885276003450 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 885276003451 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885276003452 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885276003453 major curlin subunit; Provisional; Region: csgA; PRK10051 885276003454 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885276003455 Curlin associated repeat; Region: Curlin_rpt; pfam07012 885276003456 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 885276003457 Fimbrial protein; Region: Fimbrial; cl01416 885276003458 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 885276003459 putative ADP-ribose binding site [chemical binding]; other site 885276003460 putative active site [active] 885276003461 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 885276003462 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 885276003463 putative active site [active] 885276003464 catalytic site [active] 885276003465 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 885276003466 putative active site [active] 885276003467 catalytic site [active] 885276003468 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 885276003469 Acyltransferase family; Region: Acyl_transf_3; pfam01757 885276003470 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 885276003471 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 885276003472 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 885276003473 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 885276003474 Ligand binding site; other site 885276003475 DXD motif; other site 885276003476 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885276003477 lipoprotein; Provisional; Region: PRK10175 885276003478 secY/secA suppressor protein; Provisional; Region: PRK11467 885276003479 drug efflux system protein MdtG; Provisional; Region: PRK09874 885276003480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276003481 putative substrate translocation pore; other site 885276003482 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 885276003483 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885276003484 putative acyl-acceptor binding pocket; other site 885276003485 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 885276003486 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 885276003487 active site residue [active] 885276003488 hypothetical protein; Provisional; Region: PRK03757 885276003489 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 885276003490 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 885276003491 hydroxyglutarate oxidase; Provisional; Region: PRK11728 885276003492 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 885276003493 DNA damage-inducible protein I; Provisional; Region: PRK10597 885276003494 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 885276003495 active site 885276003496 substrate binding pocket [chemical binding]; other site 885276003497 dimer interface [polypeptide binding]; other site 885276003498 lipoprotein; Provisional; Region: PRK10598 885276003499 glutaredoxin 2; Provisional; Region: PRK10387 885276003500 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 885276003501 C-terminal domain interface [polypeptide binding]; other site 885276003502 GSH binding site (G-site) [chemical binding]; other site 885276003503 catalytic residues [active] 885276003504 putative dimer interface [polypeptide binding]; other site 885276003505 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 885276003506 N-terminal domain interface [polypeptide binding]; other site 885276003507 multidrug resistance protein MdtH; Provisional; Region: PRK11646 885276003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276003509 putative substrate translocation pore; other site 885276003510 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 885276003511 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 885276003512 hypothetical protein; Provisional; Region: PRK11239 885276003513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 885276003514 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 885276003515 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885276003516 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885276003517 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 885276003518 MviN-like protein; Region: MVIN; pfam03023 885276003519 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 885276003520 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 885276003521 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 885276003522 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 885276003523 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 885276003524 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 885276003525 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 885276003526 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 885276003527 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885276003528 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 885276003529 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 885276003530 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 885276003531 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 885276003532 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 885276003533 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885276003534 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 885276003535 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 885276003536 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 885276003537 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885276003538 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 885276003539 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 885276003540 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885276003541 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 885276003542 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 885276003543 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 885276003544 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 885276003545 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 885276003546 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 885276003547 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 885276003548 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 885276003549 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 885276003550 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 885276003551 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 885276003552 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 885276003553 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 885276003554 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 885276003555 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 885276003556 homodimer interface [polypeptide binding]; other site 885276003557 oligonucleotide binding site [chemical binding]; other site 885276003558 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 885276003559 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 885276003560 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 885276003561 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276003562 RNA binding surface [nucleotide binding]; other site 885276003563 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 885276003564 active site 885276003565 Maf-like protein; Region: Maf; pfam02545 885276003566 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 885276003567 active site 885276003568 dimer interface [polypeptide binding]; other site 885276003569 hypothetical protein; Provisional; Region: PRK11193 885276003570 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 885276003571 putative phosphate acyltransferase; Provisional; Region: PRK05331 885276003572 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 885276003573 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 885276003574 dimer interface [polypeptide binding]; other site 885276003575 active site 885276003576 CoA binding pocket [chemical binding]; other site 885276003577 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 885276003578 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885276003579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 885276003580 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 885276003581 NAD(P) binding site [chemical binding]; other site 885276003582 homotetramer interface [polypeptide binding]; other site 885276003583 homodimer interface [polypeptide binding]; other site 885276003584 active site 885276003585 acyl carrier protein; Provisional; Region: acpP; PRK00982 885276003586 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 885276003587 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885276003588 dimer interface [polypeptide binding]; other site 885276003589 active site 885276003590 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 885276003591 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 885276003592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276003593 catalytic residue [active] 885276003594 conserved hypothetical protein, YceG family; Region: TIGR00247 885276003595 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 885276003596 dimerization interface [polypeptide binding]; other site 885276003597 thymidylate kinase; Validated; Region: tmk; PRK00698 885276003598 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 885276003599 TMP-binding site; other site 885276003600 ATP-binding site [chemical binding]; other site 885276003601 DNA polymerase III subunit delta'; Validated; Region: PRK07993 885276003602 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 885276003603 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 885276003604 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 885276003605 active site 885276003606 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 885276003607 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276003608 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276003609 active site turn [active] 885276003610 phosphorylation site [posttranslational modification] 885276003611 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 885276003612 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276003613 N-terminal plug; other site 885276003614 ligand-binding site [chemical binding]; other site 885276003615 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 885276003616 nucleotide binding site/active site [active] 885276003617 HIT family signature motif; other site 885276003618 catalytic residue [active] 885276003619 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 885276003620 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 885276003621 putative dimer interface [polypeptide binding]; other site 885276003622 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 885276003623 thiamine kinase; Region: ycfN_thiK; TIGR02721 885276003624 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 885276003625 active site 885276003626 substrate binding site [chemical binding]; other site 885276003627 ATP binding site [chemical binding]; other site 885276003628 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 885276003629 beta-hexosaminidase; Provisional; Region: PRK05337 885276003630 hypothetical protein; Provisional; Region: PRK04940 885276003631 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 885276003632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276003633 hypothetical protein; Provisional; Region: PRK11280 885276003634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885276003635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276003636 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276003637 L,D-transpeptidase; Provisional; Region: PRK10260 885276003638 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276003639 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276003640 transcription-repair coupling factor; Provisional; Region: PRK10689 885276003641 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 885276003642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276003643 ATP binding site [chemical binding]; other site 885276003644 putative Mg++ binding site [ion binding]; other site 885276003645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276003646 nucleotide binding region [chemical binding]; other site 885276003647 ATP-binding site [chemical binding]; other site 885276003648 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 885276003649 Predicted membrane protein [Function unknown]; Region: COG4763 885276003650 Acyltransferase family; Region: Acyl_transf_3; pfam01757 885276003651 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 885276003652 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 885276003653 FtsX-like permease family; Region: FtsX; pfam02687 885276003654 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 885276003655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885276003656 Walker A/P-loop; other site 885276003657 ATP binding site [chemical binding]; other site 885276003658 Q-loop/lid; other site 885276003659 ABC transporter signature motif; other site 885276003660 Walker B; other site 885276003661 D-loop; other site 885276003662 H-loop/switch region; other site 885276003663 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 885276003664 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 885276003665 FtsX-like permease family; Region: FtsX; pfam02687 885276003666 fructokinase; Reviewed; Region: PRK09557 885276003667 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276003668 nucleotide binding site [chemical binding]; other site 885276003669 NAD-dependent deacetylase; Provisional; Region: PRK00481 885276003670 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 885276003671 NAD+ binding site [chemical binding]; other site 885276003672 substrate binding site [chemical binding]; other site 885276003673 Zn binding site [ion binding]; other site 885276003674 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 885276003675 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 885276003676 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 885276003677 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 885276003678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276003679 dimer interface [polypeptide binding]; other site 885276003680 conserved gate region; other site 885276003681 putative PBP binding loops; other site 885276003682 ABC-ATPase subunit interface; other site 885276003683 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 885276003684 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885276003685 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 885276003686 dimer interface [polypeptide binding]; other site 885276003687 active site 885276003688 Int/Topo IB signature motif; other site 885276003689 exonuclease VIII; Reviewed; Region: PRK09709 885276003690 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 885276003691 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 885276003692 active site 885276003693 catalytic site [active] 885276003694 substrate binding site [chemical binding]; other site 885276003695 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 885276003696 DicB protein; Region: DicB; pfam05358 885276003697 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 885276003698 transcriptional repressor DicA; Reviewed; Region: PRK09706 885276003699 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 885276003700 primosomal protein DnaI; Provisional; Region: PRK02854 885276003701 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 885276003702 Protein of unknown function (DUF968); Region: DUF968; pfam06147 885276003703 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 885276003704 Antitermination protein; Region: Antiterm; pfam03589 885276003705 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 885276003706 Protein of unknown function (DUF3927); Region: DUF3927; pfam13064 885276003707 anti-adapter protein IraM; Provisional; Region: PRK09919 885276003708 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 885276003709 Lysis protein S; Region: Lysis_S; pfam04971 885276003710 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 885276003711 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 885276003712 catalytic residues [active] 885276003713 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 885276003714 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 885276003715 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 885276003716 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 885276003717 Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220 885276003718 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 885276003719 gpW; Region: gpW; pfam02831 885276003720 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 885276003721 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 885276003722 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 885276003723 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 885276003724 tandem repeat interface [polypeptide binding]; other site 885276003725 oligomer interface [polypeptide binding]; other site 885276003726 active site residues [active] 885276003727 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 885276003728 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 885276003729 DNA packaging protein FI; Region: Packaging_FI; pfam14000 885276003730 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 885276003731 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 885276003732 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 885276003733 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 885276003734 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 885276003735 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 885276003736 phage tail assembly protein T; Region: phage_lam_T; TIGR01715 885276003737 Phage-related minor tail protein [Function unknown]; Region: COG5281 885276003738 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 885276003739 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 885276003740 Phage-related protein [Function unknown]; Region: COG4718 885276003741 Phage-related protein [Function unknown]; Region: gp18; COG4672 885276003742 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 885276003743 MPN+ (JAMM) motif; other site 885276003744 Zinc-binding site [ion binding]; other site 885276003745 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885276003746 NlpC/P60 family; Region: NLPC_P60; cl17555 885276003747 Phage-related protein, tail component [Function unknown]; Region: COG4723 885276003748 Phage-related protein, tail component [Function unknown]; Region: COG4733 885276003749 Putative phage tail protein; Region: Phage-tail_3; pfam13550 885276003750 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 885276003751 Interdomain contacts; other site 885276003752 Cytokine receptor motif; other site 885276003753 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 885276003754 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 885276003755 Fibronectin type III protein; Region: DUF3672; pfam12421 885276003756 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 885276003757 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 885276003758 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885276003759 S-adenosylmethionine binding site [chemical binding]; other site 885276003760 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 885276003761 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 885276003762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276003763 dimer interface [polypeptide binding]; other site 885276003764 conserved gate region; other site 885276003765 putative PBP binding loops; other site 885276003766 ABC-ATPase subunit interface; other site 885276003767 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 885276003768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276003769 Walker A/P-loop; other site 885276003770 ATP binding site [chemical binding]; other site 885276003771 Q-loop/lid; other site 885276003772 ABC transporter signature motif; other site 885276003773 Walker B; other site 885276003774 D-loop; other site 885276003775 H-loop/switch region; other site 885276003776 TOBE domain; Region: TOBE_2; pfam08402 885276003777 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 885276003778 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 885276003779 metal binding site [ion binding]; metal-binding site 885276003780 dimer interface [polypeptide binding]; other site 885276003781 Uncharacterized conserved protein [Function unknown]; Region: COG2850 885276003782 Cupin-like domain; Region: Cupin_8; pfam13621 885276003783 sensor protein PhoQ; Provisional; Region: PRK10815 885276003784 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 885276003785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 885276003786 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 885276003787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276003788 ATP binding site [chemical binding]; other site 885276003789 Mg2+ binding site [ion binding]; other site 885276003790 G-X-G motif; other site 885276003791 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 885276003792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276003793 active site 885276003794 phosphorylation site [posttranslational modification] 885276003795 intermolecular recognition site; other site 885276003796 dimerization interface [polypeptide binding]; other site 885276003797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276003798 DNA binding site [nucleotide binding] 885276003799 adenylosuccinate lyase; Provisional; Region: PRK09285 885276003800 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 885276003801 tetramer interface [polypeptide binding]; other site 885276003802 active site 885276003803 putative lysogenization regulator; Reviewed; Region: PRK00218 885276003804 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 885276003805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 885276003806 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 885276003807 nudix motif; other site 885276003808 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 885276003809 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 885276003810 probable active site [active] 885276003811 isocitrate dehydrogenase; Validated; Region: PRK07362 885276003812 isocitrate dehydrogenase; Reviewed; Region: PRK07006 885276003813 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 885276003814 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885276003815 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 885276003816 dimer interface [polypeptide binding]; other site 885276003817 active site 885276003818 Int/Topo IB signature motif; other site 885276003819 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 885276003820 ASCH domain; Region: ASCH; pfam04266 885276003821 Protein of unknown function (DUF550); Region: DUF550; pfam04447 885276003822 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 885276003823 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 885276003824 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 885276003825 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 885276003826 phage recombination protein Bet; Region: bet_lambda; TIGR01913 885276003827 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 885276003828 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 885276003829 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 885276003830 Antirestriction protein Ral; Region: Ral; pfam11058 885276003831 Superinfection exclusion protein B; Region: SieB; pfam14163 885276003832 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 885276003833 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 885276003834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276003835 non-specific DNA binding site [nucleotide binding]; other site 885276003836 salt bridge; other site 885276003837 sequence-specific DNA binding site [nucleotide binding]; other site 885276003838 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 885276003839 Catalytic site [active] 885276003840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276003841 non-specific DNA binding site [nucleotide binding]; other site 885276003842 salt bridge; other site 885276003843 sequence-specific DNA binding site [nucleotide binding]; other site 885276003844 Bacteriophage CII protein; Region: Phage_CII; pfam05269 885276003845 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 885276003846 Replication protein P; Region: Phage_lambda_P; pfam06992 885276003847 NinB protein; Region: NinB; pfam05772 885276003848 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 885276003849 hypothetical protein; Region: PHA01519 885276003850 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 885276003851 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 885276003852 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276003853 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276003854 trimer interface [polypeptide binding]; other site 885276003855 eyelet of channel; other site 885276003856 Lysis protein S; Region: Lysis_S; pfam04971 885276003857 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 885276003858 catalytic residues [active] 885276003859 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 885276003860 Bor protein; Region: Lambda_Bor; pfam06291 885276003861 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 885276003862 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 885276003863 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 885276003864 gpW; Region: gpW; pfam02831 885276003865 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 885276003866 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 885276003867 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 885276003868 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 885276003869 DNA packaging protein FI; Region: Packaging_FI; pfam14000 885276003870 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 885276003871 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 885276003872 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 885276003873 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 885276003874 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 885276003875 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 885276003876 Minor tail protein T; Region: Phage_tail_T; cl05636 885276003877 Phage-related minor tail protein [Function unknown]; Region: COG5281 885276003878 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 885276003879 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 885276003880 Phage-related protein [Function unknown]; Region: COG4718 885276003881 Phage-related protein [Function unknown]; Region: gp18; COG4672 885276003882 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 885276003883 MPN+ (JAMM) motif; other site 885276003884 Zinc-binding site [ion binding]; other site 885276003885 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885276003886 NlpC/P60 family; Region: NLPC_P60; cl17555 885276003887 Phage-related protein, tail component [Function unknown]; Region: COG4723 885276003888 Phage-related protein, tail component [Function unknown]; Region: COG4733 885276003889 Putative phage tail protein; Region: Phage-tail_3; pfam13550 885276003890 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 885276003891 Interdomain contacts; other site 885276003892 Cytokine receptor motif; other site 885276003893 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 885276003894 Fibronectin type III protein; Region: DUF3672; pfam12421 885276003895 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 885276003896 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 885276003897 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885276003898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276003899 ABC-ATPase subunit interface; other site 885276003900 dimer interface [polypeptide binding]; other site 885276003901 putative PBP binding regions; other site 885276003902 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885276003903 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276003904 ABC-ATPase subunit interface; other site 885276003905 dimer interface [polypeptide binding]; other site 885276003906 putative PBP binding regions; other site 885276003907 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 885276003908 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 885276003909 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 885276003910 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 885276003911 metal binding site [ion binding]; metal-binding site 885276003912 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 885276003913 transcriptional regulator MirA; Provisional; Region: PRK15043 885276003914 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 885276003915 DNA binding residues [nucleotide binding] 885276003916 Sensors of blue-light using FAD; Region: BLUF; smart01034 885276003917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276003918 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 885276003919 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 885276003920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276003921 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885276003922 Autotransporter beta-domain; Region: Autotransporter; cl17461 885276003923 Autotransporter beta-domain; Region: Autotransporter; smart00869 885276003924 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 885276003925 cell division inhibitor MinD; Provisional; Region: PRK10818 885276003926 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 885276003927 Switch I; other site 885276003928 Switch II; other site 885276003929 septum formation inhibitor; Reviewed; Region: minC; PRK03511 885276003930 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 885276003931 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 885276003932 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 885276003933 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 885276003934 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 885276003935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 885276003936 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 885276003937 hypothetical protein; Provisional; Region: PRK10691 885276003938 hypothetical protein; Provisional; Region: PRK05170 885276003939 Haemolysin E (HlyE); Region: HlyE; cl11627 885276003940 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 885276003941 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 885276003942 Catalytic site [active] 885276003943 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 885276003944 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 885276003945 active site 885276003946 DNA binding site [nucleotide binding] 885276003947 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 885276003948 disulfide bond formation protein B; Provisional; Region: PRK01749 885276003949 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885276003950 transmembrane helices; other site 885276003951 fatty acid metabolism regulator; Provisional; Region: PRK04984 885276003952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276003953 DNA-binding site [nucleotide binding]; DNA binding site 885276003954 FadR C-terminal domain; Region: FadR_C; pfam07840 885276003955 SpoVR family protein; Provisional; Region: PRK11767 885276003956 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 885276003957 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 885276003958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276003959 alanine racemase; Reviewed; Region: dadX; PRK03646 885276003960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 885276003961 active site 885276003962 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885276003963 substrate binding site [chemical binding]; other site 885276003964 catalytic residues [active] 885276003965 dimer interface [polypeptide binding]; other site 885276003966 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 885276003967 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 885276003968 TrkA-C domain; Region: TrkA_C; pfam02080 885276003969 Transporter associated domain; Region: CorC_HlyC; smart01091 885276003970 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 885276003971 dimer interface [polypeptide binding]; other site 885276003972 catalytic triad [active] 885276003973 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 885276003974 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885276003975 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885276003976 catalytic residue [active] 885276003977 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 885276003978 Flagellar regulator YcgR; Region: YcgR; pfam07317 885276003979 PilZ domain; Region: PilZ; pfam07238 885276003980 hypothetical protein; Provisional; Region: PRK10457 885276003981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276003982 N-terminal plug; other site 885276003983 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 885276003984 ligand-binding site [chemical binding]; other site 885276003985 molybdenum transport protein ModD; Provisional; Region: PRK06096 885276003986 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 885276003987 dimerization interface [polypeptide binding]; other site 885276003988 active site 885276003989 Methyltransferase domain; Region: Methyltransf_31; pfam13847 885276003990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276003991 S-adenosylmethionine binding site [chemical binding]; other site 885276003992 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885276003993 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276003994 Walker A/P-loop; other site 885276003995 ATP binding site [chemical binding]; other site 885276003996 Q-loop/lid; other site 885276003997 ABC transporter signature motif; other site 885276003998 Walker B; other site 885276003999 D-loop; other site 885276004000 H-loop/switch region; other site 885276004001 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885276004002 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276004003 ABC-ATPase subunit interface; other site 885276004004 dimer interface [polypeptide binding]; other site 885276004005 putative PBP binding regions; other site 885276004006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 885276004007 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 885276004008 putative metal binding site [ion binding]; other site 885276004009 trehalase; Provisional; Region: treA; PRK13271 885276004010 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 885276004011 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 885276004012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 885276004013 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276004014 dimerization domain swap beta strand [polypeptide binding]; other site 885276004015 regulatory protein interface [polypeptide binding]; other site 885276004016 active site 885276004017 regulatory phosphorylation site [posttranslational modification]; other site 885276004018 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885276004019 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885276004020 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 885276004021 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 885276004022 Dak1 domain; Region: Dak1; pfam02733 885276004023 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 885276004024 PAS domain; Region: PAS; smart00091 885276004025 putative active site [active] 885276004026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276004027 Walker A motif; other site 885276004028 ATP binding site [chemical binding]; other site 885276004029 Walker B motif; other site 885276004030 arginine finger; other site 885276004031 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276004032 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 885276004033 GTP-binding protein YchF; Reviewed; Region: PRK09601 885276004034 YchF GTPase; Region: YchF; cd01900 885276004035 G1 box; other site 885276004036 GTP/Mg2+ binding site [chemical binding]; other site 885276004037 Switch I region; other site 885276004038 G2 box; other site 885276004039 Switch II region; other site 885276004040 G3 box; other site 885276004041 G4 box; other site 885276004042 G5 box; other site 885276004043 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 885276004044 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 885276004045 putative active site [active] 885276004046 catalytic residue [active] 885276004047 hypothetical protein; Provisional; Region: PRK10692 885276004048 putative transporter; Provisional; Region: PRK11660 885276004049 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 885276004050 Sulfate transporter family; Region: Sulfate_transp; pfam00916 885276004051 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 885276004052 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 885276004053 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 885276004054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276004055 active site 885276004056 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 885276004057 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 885276004058 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 885276004059 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 885276004060 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 885276004061 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 885276004062 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 885276004063 tRNA; other site 885276004064 putative tRNA binding site [nucleotide binding]; other site 885276004065 putative NADP binding site [chemical binding]; other site 885276004066 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 885276004067 peptide chain release factor 1; Validated; Region: prfA; PRK00591 885276004068 This domain is found in peptide chain release factors; Region: PCRF; smart00937 885276004069 RF-1 domain; Region: RF-1; pfam00472 885276004070 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 885276004071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276004072 hypothetical protein; Provisional; Region: PRK10278 885276004073 hypothetical protein; Provisional; Region: PRK10941 885276004074 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 885276004075 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 885276004076 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885276004077 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 885276004078 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 885276004079 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 885276004080 cation transport regulator; Reviewed; Region: chaB; PRK09582 885276004081 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 885276004082 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 885276004083 putative active site pocket [active] 885276004084 dimerization interface [polypeptide binding]; other site 885276004085 putative catalytic residue [active] 885276004086 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 885276004087 putative invasin; Provisional; Region: PRK10177 885276004088 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885276004089 transcriptional regulator NarL; Provisional; Region: PRK10651 885276004090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276004091 active site 885276004092 phosphorylation site [posttranslational modification] 885276004093 intermolecular recognition site; other site 885276004094 dimerization interface [polypeptide binding]; other site 885276004095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276004096 DNA binding residues [nucleotide binding] 885276004097 dimerization interface [polypeptide binding]; other site 885276004098 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 885276004099 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 885276004100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276004101 dimerization interface [polypeptide binding]; other site 885276004102 Histidine kinase; Region: HisKA_3; pfam07730 885276004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276004104 ATP binding site [chemical binding]; other site 885276004105 Mg2+ binding site [ion binding]; other site 885276004106 G-X-G motif; other site 885276004107 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 885276004108 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 885276004109 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 885276004110 [4Fe-4S] binding site [ion binding]; other site 885276004111 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885276004112 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885276004113 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885276004114 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 885276004115 molybdopterin cofactor binding site; other site 885276004116 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 885276004117 4Fe-4S binding domain; Region: Fer4; cl02805 885276004118 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 885276004119 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 885276004120 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 885276004121 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 885276004122 dimer interface [polypeptide binding]; other site 885276004123 active site 885276004124 CoA binding pocket [chemical binding]; other site 885276004125 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885276004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885276004127 NAD(P) binding site [chemical binding]; other site 885276004128 active site 885276004129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885276004130 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 885276004131 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 885276004132 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 885276004133 active site 885276004134 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 885276004135 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 885276004136 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 885276004137 putative di-iron ligands [ion binding]; other site 885276004138 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 885276004139 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 885276004140 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 885276004141 putative active site [active] 885276004142 putative substrate binding site [chemical binding]; other site 885276004143 putative cosubstrate binding site; other site 885276004144 catalytic site [active] 885276004145 SEC-C motif; Region: SEC-C; pfam02810 885276004146 hypothetical protein; Provisional; Region: PRK04233 885276004147 hypothetical protein; Provisional; Region: PRK10279 885276004148 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 885276004149 active site 885276004150 nucleophile elbow; other site 885276004151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276004152 active site 885276004153 response regulator of RpoS; Provisional; Region: PRK10693 885276004154 phosphorylation site [posttranslational modification] 885276004155 intermolecular recognition site; other site 885276004156 dimerization interface [polypeptide binding]; other site 885276004157 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 885276004158 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 885276004159 active site 885276004160 tetramer interface; other site 885276004161 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 885276004162 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 885276004163 thymidine kinase; Provisional; Region: PRK04296 885276004164 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 885276004165 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 885276004166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 885276004167 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 885276004168 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 885276004169 putative catalytic cysteine [active] 885276004170 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 885276004171 putative active site [active] 885276004172 metal binding site [ion binding]; metal-binding site 885276004173 hypothetical protein; Provisional; Region: PRK11111 885276004174 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 885276004175 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 885276004176 peptide binding site [polypeptide binding]; other site 885276004177 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 885276004178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004179 dimer interface [polypeptide binding]; other site 885276004180 conserved gate region; other site 885276004181 putative PBP binding loops; other site 885276004182 ABC-ATPase subunit interface; other site 885276004183 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 885276004184 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885276004185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004186 dimer interface [polypeptide binding]; other site 885276004187 conserved gate region; other site 885276004188 putative PBP binding loops; other site 885276004189 ABC-ATPase subunit interface; other site 885276004190 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 885276004191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276004192 Walker A/P-loop; other site 885276004193 ATP binding site [chemical binding]; other site 885276004194 Q-loop/lid; other site 885276004195 ABC transporter signature motif; other site 885276004196 Walker B; other site 885276004197 D-loop; other site 885276004198 H-loop/switch region; other site 885276004199 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885276004200 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 885276004201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276004202 Walker A/P-loop; other site 885276004203 ATP binding site [chemical binding]; other site 885276004204 Q-loop/lid; other site 885276004205 ABC transporter signature motif; other site 885276004206 Walker B; other site 885276004207 D-loop; other site 885276004208 H-loop/switch region; other site 885276004209 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885276004210 dsDNA-mimic protein; Reviewed; Region: PRK05094 885276004211 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 885276004212 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 885276004213 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 885276004214 putative active site [active] 885276004215 catalytic site [active] 885276004216 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 885276004217 putative active site [active] 885276004218 catalytic site [active] 885276004219 voltage-gated potassium channel; Provisional; Region: PRK10537 885276004220 Ion channel; Region: Ion_trans_2; pfam07885 885276004221 TrkA-N domain; Region: TrkA_N; pfam02254 885276004222 YciI-like protein; Reviewed; Region: PRK11370 885276004223 transport protein TonB; Provisional; Region: PRK10819 885276004224 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 885276004225 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 885276004226 intracellular septation protein A; Reviewed; Region: PRK00259 885276004227 hypothetical protein; Provisional; Region: PRK02868 885276004228 outer membrane protein W; Provisional; Region: PRK10959 885276004229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 885276004230 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 885276004231 dimerization interface [polypeptide binding]; other site 885276004232 metal binding site [ion binding]; metal-binding site 885276004233 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 885276004234 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 885276004235 substrate binding site [chemical binding]; other site 885276004236 active site 885276004237 catalytic residues [active] 885276004238 heterodimer interface [polypeptide binding]; other site 885276004239 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 885276004240 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 885276004241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276004242 catalytic residue [active] 885276004243 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 885276004244 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 885276004245 active site 885276004246 ribulose/triose binding site [chemical binding]; other site 885276004247 phosphate binding site [ion binding]; other site 885276004248 substrate (anthranilate) binding pocket [chemical binding]; other site 885276004249 product (indole) binding pocket [chemical binding]; other site 885276004250 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 885276004251 active site 885276004252 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 885276004253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 885276004254 glutamine binding [chemical binding]; other site 885276004255 catalytic triad [active] 885276004256 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 885276004257 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 885276004258 anthranilate synthase component I; Provisional; Region: PRK13564 885276004259 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 885276004260 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 885276004261 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 885276004262 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 885276004263 active site 885276004264 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 885276004265 hypothetical protein; Provisional; Region: PRK11630 885276004266 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 885276004267 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 885276004268 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276004269 RNA binding surface [nucleotide binding]; other site 885276004270 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 885276004271 probable active site [active] 885276004272 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 885276004273 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 885276004274 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 885276004275 homodimer interface [polypeptide binding]; other site 885276004276 Walker A motif; other site 885276004277 ATP binding site [chemical binding]; other site 885276004278 hydroxycobalamin binding site [chemical binding]; other site 885276004279 Walker B motif; other site 885276004280 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 885276004281 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 885276004282 NADP binding site [chemical binding]; other site 885276004283 homodimer interface [polypeptide binding]; other site 885276004284 active site 885276004285 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 885276004286 putative inner membrane peptidase; Provisional; Region: PRK11778 885276004287 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 885276004288 tandem repeat interface [polypeptide binding]; other site 885276004289 oligomer interface [polypeptide binding]; other site 885276004290 active site residues [active] 885276004291 hypothetical protein; Provisional; Region: PRK11037 885276004292 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 885276004293 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 885276004294 active site 885276004295 interdomain interaction site; other site 885276004296 putative metal-binding site [ion binding]; other site 885276004297 nucleotide binding site [chemical binding]; other site 885276004298 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 885276004299 domain I; other site 885276004300 DNA binding groove [nucleotide binding] 885276004301 phosphate binding site [ion binding]; other site 885276004302 domain II; other site 885276004303 domain III; other site 885276004304 nucleotide binding site [chemical binding]; other site 885276004305 catalytic site [active] 885276004306 domain IV; other site 885276004307 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885276004308 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885276004309 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 885276004310 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 885276004311 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 885276004312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276004313 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 885276004314 substrate binding site [chemical binding]; other site 885276004315 putative dimerization interface [polypeptide binding]; other site 885276004316 aconitate hydratase; Validated; Region: PRK09277 885276004317 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 885276004318 substrate binding site [chemical binding]; other site 885276004319 ligand binding site [chemical binding]; other site 885276004320 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 885276004321 substrate binding site [chemical binding]; other site 885276004322 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 885276004323 dimerization interface [polypeptide binding]; other site 885276004324 active site 885276004325 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885276004326 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 885276004327 active site 885276004328 Predicted membrane protein [Function unknown]; Region: COG3771 885276004329 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 885276004330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 885276004331 TPR motif; other site 885276004332 binding surface 885276004333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276004334 binding surface 885276004335 TPR motif; other site 885276004336 translation initiation factor Sui1; Validated; Region: PRK06824 885276004337 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 885276004338 putative rRNA binding site [nucleotide binding]; other site 885276004339 lipoprotein; Provisional; Region: PRK10540 885276004340 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276004341 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276004342 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276004343 hypothetical protein; Provisional; Region: PRK13658 885276004344 RNase II stability modulator; Provisional; Region: PRK10060 885276004345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276004346 putative active site [active] 885276004347 heme pocket [chemical binding]; other site 885276004348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276004349 metal binding site [ion binding]; metal-binding site 885276004350 active site 885276004351 I-site; other site 885276004352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276004353 exoribonuclease II; Provisional; Region: PRK05054 885276004354 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 885276004355 RNB domain; Region: RNB; pfam00773 885276004356 S1 RNA binding domain; Region: S1; pfam00575 885276004357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 885276004358 Uncharacterized conserved protein [Function unknown]; Region: COG2128 885276004359 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 885276004360 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 885276004361 NAD binding site [chemical binding]; other site 885276004362 homotetramer interface [polypeptide binding]; other site 885276004363 homodimer interface [polypeptide binding]; other site 885276004364 substrate binding site [chemical binding]; other site 885276004365 active site 885276004366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885276004367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276004368 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 885276004369 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276004370 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276004371 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 885276004372 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 885276004373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276004374 putative substrate translocation pore; other site 885276004375 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 885276004376 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276004377 Walker A/P-loop; other site 885276004378 ATP binding site [chemical binding]; other site 885276004379 Q-loop/lid; other site 885276004380 ABC transporter signature motif; other site 885276004381 Walker B; other site 885276004382 D-loop; other site 885276004383 H-loop/switch region; other site 885276004384 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 885276004385 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276004386 Walker A/P-loop; other site 885276004387 ATP binding site [chemical binding]; other site 885276004388 Q-loop/lid; other site 885276004389 ABC transporter signature motif; other site 885276004390 Walker B; other site 885276004391 D-loop; other site 885276004392 H-loop/switch region; other site 885276004393 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885276004394 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 885276004395 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885276004396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004397 dimer interface [polypeptide binding]; other site 885276004398 conserved gate region; other site 885276004399 putative PBP binding loops; other site 885276004400 ABC-ATPase subunit interface; other site 885276004401 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 885276004402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004403 dimer interface [polypeptide binding]; other site 885276004404 conserved gate region; other site 885276004405 putative PBP binding loops; other site 885276004406 ABC-ATPase subunit interface; other site 885276004407 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 885276004408 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 885276004409 peptide binding site [polypeptide binding]; other site 885276004410 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 885276004411 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 885276004412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276004413 Walker A motif; other site 885276004414 ATP binding site [chemical binding]; other site 885276004415 Walker B motif; other site 885276004416 arginine finger; other site 885276004417 phage shock protein PspA; Provisional; Region: PRK10698 885276004418 phage shock protein B; Provisional; Region: pspB; PRK09458 885276004419 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 885276004420 phage shock protein C; Region: phageshock_pspC; TIGR02978 885276004421 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 885276004422 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 885276004423 active site residue [active] 885276004424 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 885276004425 sucrose phosphorylase; Provisional; Region: PRK13840 885276004426 active site 885276004427 homodimer interface [polypeptide binding]; other site 885276004428 catalytic site [active] 885276004429 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 885276004430 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 885276004431 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 885276004432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004433 dimer interface [polypeptide binding]; other site 885276004434 conserved gate region; other site 885276004435 putative PBP binding loops; other site 885276004436 ABC-ATPase subunit interface; other site 885276004437 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 885276004438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004439 dimer interface [polypeptide binding]; other site 885276004440 conserved gate region; other site 885276004441 putative PBP binding loops; other site 885276004442 ABC-ATPase subunit interface; other site 885276004443 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276004444 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 885276004445 putative NAD(P) binding site [chemical binding]; other site 885276004446 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 885276004447 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 885276004448 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885276004449 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885276004450 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 885276004451 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 885276004452 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 885276004453 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 885276004454 beta-phosphoglucomutase; Region: bPGM; TIGR01990 885276004455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276004456 motif II; other site 885276004457 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 885276004458 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 885276004459 Walker A/P-loop; other site 885276004460 ATP binding site [chemical binding]; other site 885276004461 Q-loop/lid; other site 885276004462 ABC transporter signature motif; other site 885276004463 Walker B; other site 885276004464 D-loop; other site 885276004465 H-loop/switch region; other site 885276004466 TOBE domain; Region: TOBE_2; pfam08402 885276004467 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 885276004468 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885276004469 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276004470 DNA binding site [nucleotide binding] 885276004471 domain linker motif; other site 885276004472 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 885276004473 putative dimerization interface [polypeptide binding]; other site 885276004474 putative ligand binding site [chemical binding]; other site 885276004475 Predicted ATPase [General function prediction only]; Region: COG3106 885276004476 hypothetical protein; Provisional; Region: PRK05415 885276004477 TIGR01620 family protein; Region: hyp_HI0043 885276004478 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 885276004479 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 885276004480 putative aromatic amino acid binding site; other site 885276004481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276004482 Walker A motif; other site 885276004483 ATP binding site [chemical binding]; other site 885276004484 Walker B motif; other site 885276004485 arginine finger; other site 885276004486 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 885276004487 dimer interface [polypeptide binding]; other site 885276004488 catalytic triad [active] 885276004489 peroxidatic and resolving cysteines [active] 885276004490 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 885276004491 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 885276004492 active site 885276004493 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 885276004494 NADH(P)-binding; Region: NAD_binding_10; pfam13460 885276004495 putative NAD(P) binding site [chemical binding]; other site 885276004496 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 885276004497 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885276004498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276004499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276004500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 885276004501 putative effector binding pocket; other site 885276004502 putative dimerization interface [polypeptide binding]; other site 885276004503 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 885276004504 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 885276004505 peptide binding site [polypeptide binding]; other site 885276004506 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 885276004507 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885276004508 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 885276004509 universal stress protein UspE; Provisional; Region: PRK11175 885276004510 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276004511 Ligand Binding Site [chemical binding]; other site 885276004512 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276004513 Ligand Binding Site [chemical binding]; other site 885276004514 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 885276004515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 885276004516 ligand binding site [chemical binding]; other site 885276004517 flexible hinge region; other site 885276004518 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 885276004519 putative switch regulator; other site 885276004520 non-specific DNA interactions [nucleotide binding]; other site 885276004521 DNA binding site [nucleotide binding] 885276004522 sequence specific DNA binding site [nucleotide binding]; other site 885276004523 putative cAMP binding site [chemical binding]; other site 885276004524 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 885276004525 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 885276004526 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 885276004527 DNA binding site [nucleotide binding] 885276004528 active site 885276004529 Cupin domain; Region: Cupin_2; cl17218 885276004530 Helix-turn-helix domain; Region: HTH_18; pfam12833 885276004531 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276004532 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 885276004533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 885276004534 Smr domain; Region: Smr; pfam01713 885276004535 PAS domain S-box; Region: sensory_box; TIGR00229 885276004536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276004537 putative active site [active] 885276004538 heme pocket [chemical binding]; other site 885276004539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276004540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276004541 metal binding site [ion binding]; metal-binding site 885276004542 active site 885276004543 I-site; other site 885276004544 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 885276004545 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 885276004546 Cl binding site [ion binding]; other site 885276004547 oligomer interface [polypeptide binding]; other site 885276004548 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 885276004549 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885276004550 ATP binding site [chemical binding]; other site 885276004551 Mg++ binding site [ion binding]; other site 885276004552 motif III; other site 885276004553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276004554 nucleotide binding region [chemical binding]; other site 885276004555 ATP-binding site [chemical binding]; other site 885276004556 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 885276004557 putative RNA binding site [nucleotide binding]; other site 885276004558 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 885276004559 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 885276004560 Ligand Binding Site [chemical binding]; other site 885276004561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276004562 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 885276004563 DNA binding site [nucleotide binding] 885276004564 active site 885276004565 Int/Topo IB signature motif; other site 885276004566 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 885276004567 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885276004568 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276004569 Ligand Binding Site [chemical binding]; other site 885276004570 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276004571 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276004572 trimer interface [polypeptide binding]; other site 885276004573 eyelet of channel; other site 885276004574 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 885276004575 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 885276004576 dimer interface [polypeptide binding]; other site 885276004577 PYR/PP interface [polypeptide binding]; other site 885276004578 TPP binding site [chemical binding]; other site 885276004579 substrate binding site [chemical binding]; other site 885276004580 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 885276004581 Domain of unknown function; Region: EKR; smart00890 885276004582 4Fe-4S binding domain; Region: Fer4_6; pfam12837 885276004583 4Fe-4S binding domain; Region: Fer4; pfam00037 885276004584 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 885276004585 TPP-binding site [chemical binding]; other site 885276004586 dimer interface [polypeptide binding]; other site 885276004587 metabolite-proton symporter; Region: 2A0106; TIGR00883 885276004588 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 885276004589 Domain of unknown function (DUF333); Region: DUF333; pfam03891 885276004590 heat-inducible protein; Provisional; Region: PRK10449 885276004591 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 885276004592 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 885276004593 putative ligand binding site [chemical binding]; other site 885276004594 putative NAD binding site [chemical binding]; other site 885276004595 catalytic site [active] 885276004596 hypothetical protein; Provisional; Region: PRK10695 885276004597 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 885276004598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 885276004599 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276004600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276004601 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276004602 active site 885276004603 catalytic tetrad [active] 885276004604 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 885276004605 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 885276004606 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 885276004607 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 885276004608 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885276004609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276004610 S-adenosylmethionine binding site [chemical binding]; other site 885276004611 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 885276004612 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885276004613 active site 885276004614 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 885276004615 active site 885276004616 catalytic residues [active] 885276004617 azoreductase; Reviewed; Region: PRK00170 885276004618 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885276004619 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 885276004620 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276004621 ATP binding site [chemical binding]; other site 885276004622 putative Mg++ binding site [ion binding]; other site 885276004623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276004624 nucleotide binding region [chemical binding]; other site 885276004625 ATP-binding site [chemical binding]; other site 885276004626 Helicase associated domain (HA2); Region: HA2; pfam04408 885276004627 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 885276004628 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 885276004629 Uncharacterized conserved protein [Function unknown]; Region: COG1434 885276004630 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885276004631 putative active site [active] 885276004632 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 885276004633 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 885276004634 NAD binding site [chemical binding]; other site 885276004635 catalytic residues [active] 885276004636 substrate binding site [chemical binding]; other site 885276004637 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 885276004638 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 885276004639 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 885276004640 cytochrome b561; Provisional; Region: PRK11513 885276004641 hypothetical protein; Provisional; Region: PRK10040 885276004642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885276004643 dimer interface [polypeptide binding]; other site 885276004644 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 885276004645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276004646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276004647 dimerization interface [polypeptide binding]; other site 885276004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 885276004649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 885276004650 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 885276004651 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 885276004652 hypothetical protein; Provisional; Region: PRK11415 885276004653 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 885276004654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276004655 Coenzyme A binding pocket [chemical binding]; other site 885276004656 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 885276004657 putative trimer interface [polypeptide binding]; other site 885276004658 putative CoA binding site [chemical binding]; other site 885276004659 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 885276004660 putative trimer interface [polypeptide binding]; other site 885276004661 putative CoA binding site [chemical binding]; other site 885276004662 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 885276004663 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 885276004664 gating phenylalanine in ion channel; other site 885276004665 tellurite resistance protein TehB; Provisional; Region: PRK11207 885276004666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276004667 S-adenosylmethionine binding site [chemical binding]; other site 885276004668 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 885276004669 benzoate transporter; Region: benE; TIGR00843 885276004670 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 885276004671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 885276004672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276004673 non-specific DNA binding site [nucleotide binding]; other site 885276004674 salt bridge; other site 885276004675 sequence-specific DNA binding site [nucleotide binding]; other site 885276004676 Cupin domain; Region: Cupin_2; pfam07883 885276004677 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 885276004678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885276004679 Peptidase family U32; Region: Peptidase_U32; pfam01136 885276004680 Collagenase; Region: DUF3656; pfam12392 885276004681 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 885276004682 Helix-turn-helix; Region: HTH_3; pfam01381 885276004683 sequence-specific DNA binding site [nucleotide binding]; other site 885276004684 salt bridge; other site 885276004685 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 885276004686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276004687 DNA-binding site [nucleotide binding]; DNA binding site 885276004688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276004689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276004690 homodimer interface [polypeptide binding]; other site 885276004691 catalytic residue [active] 885276004692 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 885276004693 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 885276004694 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 885276004695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276004696 Walker A/P-loop; other site 885276004697 ATP binding site [chemical binding]; other site 885276004698 Q-loop/lid; other site 885276004699 ABC transporter signature motif; other site 885276004700 Walker B; other site 885276004701 D-loop; other site 885276004702 H-loop/switch region; other site 885276004703 TOBE domain; Region: TOBE_2; pfam08402 885276004704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004705 dimer interface [polypeptide binding]; other site 885276004706 conserved gate region; other site 885276004707 putative PBP binding loops; other site 885276004708 ABC-ATPase subunit interface; other site 885276004709 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 885276004710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276004711 ABC-ATPase subunit interface; other site 885276004712 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 885276004713 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 885276004714 tetrameric interface [polypeptide binding]; other site 885276004715 NAD binding site [chemical binding]; other site 885276004716 catalytic residues [active] 885276004717 substrate binding site [chemical binding]; other site 885276004718 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 885276004719 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 885276004720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 885276004721 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 885276004722 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 885276004723 Coenzyme A binding pocket [chemical binding]; other site 885276004724 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 885276004725 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 885276004726 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276004727 N-terminal plug; other site 885276004728 ligand-binding site [chemical binding]; other site 885276004729 PQQ-like domain; Region: PQQ_2; pfam13360 885276004730 L-asparagine permease; Provisional; Region: PRK15049 885276004731 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 885276004732 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 885276004733 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 885276004734 dimer interface [polypeptide binding]; other site 885276004735 substrate binding pocket (H-site) [chemical binding]; other site 885276004736 N-terminal domain interface [polypeptide binding]; other site 885276004737 PAAR motif; Region: PAAR_motif; pfam05488 885276004738 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 885276004739 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 885276004740 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 885276004741 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 885276004742 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 885276004743 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 885276004744 PAAR motif; Region: PAAR_motif; pfam05488 885276004745 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 885276004746 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 885276004747 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 885276004748 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 885276004749 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 885276004750 putative active site [active] 885276004751 putative Zn binding site [ion binding]; other site 885276004752 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 885276004753 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 885276004754 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 885276004755 hypothetical protein; Provisional; Region: PRK10281 885276004756 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 885276004757 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 885276004758 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 885276004759 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 885276004760 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 885276004761 [4Fe-4S] binding site [ion binding]; other site 885276004762 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885276004763 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885276004764 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 885276004765 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 885276004766 molybdopterin cofactor binding site; other site 885276004767 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 885276004768 aromatic amino acid exporter; Provisional; Region: PRK11689 885276004769 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 885276004770 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 885276004771 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 885276004772 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 885276004773 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 885276004774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276004775 non-specific DNA binding site [nucleotide binding]; other site 885276004776 salt bridge; other site 885276004777 sequence-specific DNA binding site [nucleotide binding]; other site 885276004778 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 885276004779 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 885276004780 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 885276004781 NAD binding site [chemical binding]; other site 885276004782 substrate binding site [chemical binding]; other site 885276004783 catalytic Zn binding site [ion binding]; other site 885276004784 tetramer interface [polypeptide binding]; other site 885276004785 structural Zn binding site [ion binding]; other site 885276004786 malate dehydrogenase; Provisional; Region: PRK13529 885276004787 Malic enzyme, N-terminal domain; Region: malic; pfam00390 885276004788 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 885276004789 NAD(P) binding site [chemical binding]; other site 885276004790 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 885276004791 Putative biofilm-dependent modulation protein; Region: BDM; pfam10684 885276004792 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 885276004793 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 885276004794 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276004795 putative active site [active] 885276004796 heme pocket [chemical binding]; other site 885276004797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276004798 putative active site [active] 885276004799 heme pocket [chemical binding]; other site 885276004800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276004801 metal binding site [ion binding]; metal-binding site 885276004802 active site 885276004803 I-site; other site 885276004804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276004805 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276004806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276004807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 885276004808 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 885276004809 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 885276004810 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 885276004811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276004812 catalytic residue [active] 885276004813 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 885276004814 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 885276004815 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885276004816 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 885276004817 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885276004818 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 885276004819 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 885276004820 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 885276004821 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 885276004822 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 885276004823 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 885276004824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276004825 FeS/SAM binding site; other site 885276004826 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 885276004827 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885276004828 Sulfatase; Region: Sulfatase; pfam00884 885276004829 transcriptional regulator YdeO; Provisional; Region: PRK09940 885276004830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276004831 putative oxidoreductase; Provisional; Region: PRK09939 885276004832 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 885276004833 putative molybdopterin cofactor binding site [chemical binding]; other site 885276004834 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 885276004835 putative molybdopterin cofactor binding site; other site 885276004836 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 885276004837 mannosyl binding site [chemical binding]; other site 885276004838 Fimbrial protein; Region: Fimbrial; pfam00419 885276004839 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276004840 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276004841 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 885276004842 PapC N-terminal domain; Region: PapC_N; pfam13954 885276004843 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276004844 PapC C-terminal domain; Region: PapC_C; pfam13953 885276004845 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 885276004846 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276004847 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276004848 Fimbrial protein; Region: Fimbrial; cl01416 885276004849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885276004850 HipA N-terminal domain; Region: Couple_hipA; pfam13657 885276004851 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 885276004852 HipA-like N-terminal domain; Region: HipA_N; pfam07805 885276004853 HipA-like C-terminal domain; Region: HipA_C; pfam07804 885276004854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 885276004855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276004856 non-specific DNA binding site [nucleotide binding]; other site 885276004857 salt bridge; other site 885276004858 sequence-specific DNA binding site [nucleotide binding]; other site 885276004859 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 885276004860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276004861 S-adenosylmethionine binding site [chemical binding]; other site 885276004862 Predicted membrane protein [Function unknown]; Region: COG3781 885276004863 altronate oxidoreductase; Provisional; Region: PRK03643 885276004864 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885276004865 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885276004866 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276004867 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276004868 metal binding site [ion binding]; metal-binding site 885276004869 active site 885276004870 I-site; other site 885276004871 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 885276004872 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 885276004873 glutaminase; Provisional; Region: PRK00971 885276004874 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 885276004875 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 885276004876 NAD(P) binding site [chemical binding]; other site 885276004877 catalytic residues [active] 885276004878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276004879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276004880 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 885276004881 putative dimerization interface [polypeptide binding]; other site 885276004882 putative arabinose transporter; Provisional; Region: PRK03545 885276004883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276004884 putative substrate translocation pore; other site 885276004885 inner membrane protein; Provisional; Region: PRK10995 885276004886 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 885276004887 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885276004888 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 885276004889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276004890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276004891 hypothetical protein; Provisional; Region: PRK10106 885276004892 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 885276004893 beta-galactosidase; Region: BGL; TIGR03356 885276004894 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 885276004895 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 885276004896 trimer interface; other site 885276004897 sugar binding site [chemical binding]; other site 885276004898 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 885276004899 active site 885276004900 methionine cluster; other site 885276004901 phosphorylation site [posttranslational modification] 885276004902 metal binding site [ion binding]; metal-binding site 885276004903 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 885276004904 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 885276004905 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 885276004906 active site 885276004907 P-loop; other site 885276004908 phosphorylation site [posttranslational modification] 885276004909 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 885276004910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276004911 DNA-binding site [nucleotide binding]; DNA binding site 885276004912 UTRA domain; Region: UTRA; pfam07702 885276004913 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 885276004914 EamA-like transporter family; Region: EamA; pfam00892 885276004915 EamA-like transporter family; Region: EamA; pfam00892 885276004916 putative transporter; Provisional; Region: PRK10054 885276004917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276004918 putative substrate translocation pore; other site 885276004919 diguanylate cyclase; Provisional; Region: PRK09894 885276004920 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 885276004921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276004922 metal binding site [ion binding]; metal-binding site 885276004923 active site 885276004924 I-site; other site 885276004925 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 885276004926 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 885276004927 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 885276004928 active site 885276004929 Zn binding site [ion binding]; other site 885276004930 malonic semialdehyde reductase; Provisional; Region: PRK10538 885276004931 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 885276004932 putative NAD(P) binding site [chemical binding]; other site 885276004933 homodimer interface [polypeptide binding]; other site 885276004934 homotetramer interface [polypeptide binding]; other site 885276004935 active site 885276004936 Transcriptional regulators [Transcription]; Region: GntR; COG1802 885276004937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276004938 DNA-binding site [nucleotide binding]; DNA binding site 885276004939 FCD domain; Region: FCD; pfam07729 885276004940 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 885276004941 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 885276004942 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885276004943 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885276004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276004945 metabolite-proton symporter; Region: 2A0106; TIGR00883 885276004946 putative substrate translocation pore; other site 885276004947 putative oxidoreductase; Provisional; Region: PRK10083 885276004948 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 885276004949 putative NAD(P) binding site [chemical binding]; other site 885276004950 catalytic Zn binding site [ion binding]; other site 885276004951 structural Zn binding site [ion binding]; other site 885276004952 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 885276004953 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 885276004954 putative active site pocket [active] 885276004955 putative metal binding site [ion binding]; other site 885276004956 hypothetical protein; Provisional; Region: PRK02237 885276004957 hypothetical protein; Provisional; Region: PRK13659 885276004958 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 885276004959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276004960 Coenzyme A binding pocket [chemical binding]; other site 885276004961 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 885276004962 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 885276004963 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 885276004964 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 885276004965 putative [Fe4-S4] binding site [ion binding]; other site 885276004966 putative molybdopterin cofactor binding site [chemical binding]; other site 885276004967 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 885276004968 putative molybdopterin cofactor binding site; other site 885276004969 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 885276004970 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 885276004971 putative [Fe4-S4] binding site [ion binding]; other site 885276004972 putative molybdopterin cofactor binding site [chemical binding]; other site 885276004973 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 885276004974 putative molybdopterin cofactor binding site; other site 885276004975 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 885276004976 4Fe-4S binding domain; Region: Fer4; cl02805 885276004977 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 885276004978 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 885276004979 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 885276004980 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 885276004981 Cl- selectivity filter; other site 885276004982 Cl- binding residues [ion binding]; other site 885276004983 pore gating glutamate residue; other site 885276004984 dimer interface [polypeptide binding]; other site 885276004985 putative dithiobiotin synthetase; Provisional; Region: PRK12374 885276004986 AAA domain; Region: AAA_26; pfam13500 885276004987 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 885276004988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 885276004989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276004990 nucleotide binding site [chemical binding]; other site 885276004991 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 885276004992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276004993 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 885276004994 dimerization interface [polypeptide binding]; other site 885276004995 substrate binding pocket [chemical binding]; other site 885276004996 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 885276004997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276004998 putative substrate translocation pore; other site 885276004999 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 885276005000 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 885276005001 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 885276005002 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 885276005003 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885276005004 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 885276005005 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 885276005006 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 885276005007 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 885276005008 ligand binding site [chemical binding]; other site 885276005009 homodimer interface [polypeptide binding]; other site 885276005010 NAD(P) binding site [chemical binding]; other site 885276005011 trimer interface B [polypeptide binding]; other site 885276005012 trimer interface A [polypeptide binding]; other site 885276005013 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 885276005014 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276005015 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276005016 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276005017 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 885276005018 Spore germination protein; Region: Spore_permease; cl17796 885276005019 dihydromonapterin reductase; Provisional; Region: PRK06483 885276005020 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 885276005021 NADP binding site [chemical binding]; other site 885276005022 substrate binding pocket [chemical binding]; other site 885276005023 active site 885276005024 GlpM protein; Region: GlpM; pfam06942 885276005025 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 885276005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276005027 active site 885276005028 phosphorylation site [posttranslational modification] 885276005029 intermolecular recognition site; other site 885276005030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276005031 DNA binding site [nucleotide binding] 885276005032 sensor protein RstB; Provisional; Region: PRK10604 885276005033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276005034 dimerization interface [polypeptide binding]; other site 885276005035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276005036 dimer interface [polypeptide binding]; other site 885276005037 phosphorylation site [posttranslational modification] 885276005038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276005039 ATP binding site [chemical binding]; other site 885276005040 Mg2+ binding site [ion binding]; other site 885276005041 G-X-G motif; other site 885276005042 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 885276005043 fumarate hydratase; Reviewed; Region: fumC; PRK00485 885276005044 Class II fumarases; Region: Fumarase_classII; cd01362 885276005045 active site 885276005046 tetramer interface [polypeptide binding]; other site 885276005047 fumarate hydratase; Provisional; Region: PRK15389 885276005048 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 885276005049 Fumarase C-terminus; Region: Fumerase_C; pfam05683 885276005050 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 885276005051 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 885276005052 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 885276005053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 885276005054 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 885276005055 putative outer membrane porin protein; Provisional; Region: PRK11379 885276005056 glucuronide transporter; Provisional; Region: PRK09848 885276005057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005058 putative substrate translocation pore; other site 885276005059 beta-D-glucuronidase; Provisional; Region: PRK10150 885276005060 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 885276005061 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 885276005062 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 885276005063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885276005064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276005065 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 885276005066 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 885276005067 NAD binding site [chemical binding]; other site 885276005068 substrate binding site [chemical binding]; other site 885276005069 homotetramer interface [polypeptide binding]; other site 885276005070 homodimer interface [polypeptide binding]; other site 885276005071 active site 885276005072 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 885276005073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276005074 DNA binding site [nucleotide binding] 885276005075 domain linker motif; other site 885276005076 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 885276005077 putative dimerization interface [polypeptide binding]; other site 885276005078 putative ligand binding site [chemical binding]; other site 885276005079 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 885276005080 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 885276005081 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276005082 active site turn [active] 885276005083 phosphorylation site [posttranslational modification] 885276005084 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 885276005085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276005087 homodimer interface [polypeptide binding]; other site 885276005088 catalytic residue [active] 885276005089 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 885276005090 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 885276005091 active site 885276005092 purine riboside binding site [chemical binding]; other site 885276005093 putative oxidoreductase; Provisional; Region: PRK11579 885276005094 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885276005095 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885276005096 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 885276005097 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 885276005098 electron transport complex protein RsxA; Provisional; Region: PRK05151 885276005099 electron transport complex protein RnfB; Provisional; Region: PRK05113 885276005100 Putative Fe-S cluster; Region: FeS; pfam04060 885276005101 4Fe-4S binding domain; Region: Fer4; pfam00037 885276005102 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 885276005103 SLBB domain; Region: SLBB; pfam10531 885276005104 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276005105 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 885276005106 electron transport complex protein RnfG; Validated; Region: PRK01908 885276005107 electron transport complex RsxE subunit; Provisional; Region: PRK12405 885276005108 endonuclease III; Provisional; Region: PRK10702 885276005109 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 885276005110 minor groove reading motif; other site 885276005111 helix-hairpin-helix signature motif; other site 885276005112 substrate binding pocket [chemical binding]; other site 885276005113 active site 885276005114 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 885276005115 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 885276005116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005117 putative substrate translocation pore; other site 885276005118 POT family; Region: PTR2; pfam00854 885276005119 glutathionine S-transferase; Provisional; Region: PRK10542 885276005120 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 885276005121 C-terminal domain interface [polypeptide binding]; other site 885276005122 GSH binding site (G-site) [chemical binding]; other site 885276005123 dimer interface [polypeptide binding]; other site 885276005124 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 885276005125 N-terminal domain interface [polypeptide binding]; other site 885276005126 dimer interface [polypeptide binding]; other site 885276005127 substrate binding pocket (H-site) [chemical binding]; other site 885276005128 pyridoxamine kinase; Validated; Region: PRK05756 885276005129 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 885276005130 dimer interface [polypeptide binding]; other site 885276005131 pyridoxal binding site [chemical binding]; other site 885276005132 ATP binding site [chemical binding]; other site 885276005133 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 885276005134 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 885276005135 active site 885276005136 HIGH motif; other site 885276005137 dimer interface [polypeptide binding]; other site 885276005138 KMSKS motif; other site 885276005139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276005140 RNA binding surface [nucleotide binding]; other site 885276005141 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 885276005142 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 885276005143 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 885276005144 lysozyme inhibitor; Provisional; Region: PRK11372 885276005145 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 885276005146 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 885276005147 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 885276005148 transcriptional regulator SlyA; Provisional; Region: PRK03573 885276005149 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 885276005150 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 885276005151 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 885276005152 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276005153 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276005154 Fusaric acid resistance protein family; Region: FUSC; pfam04632 885276005155 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885276005156 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 885276005157 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 885276005158 E-class dimer interface [polypeptide binding]; other site 885276005159 P-class dimer interface [polypeptide binding]; other site 885276005160 active site 885276005161 Cu2+ binding site [ion binding]; other site 885276005162 Zn2+ binding site [ion binding]; other site 885276005163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276005164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276005165 active site 885276005166 catalytic tetrad [active] 885276005167 Predicted Fe-S protein [General function prediction only]; Region: COG3313 885276005168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885276005169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276005170 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 885276005171 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 885276005172 FMN binding site [chemical binding]; other site 885276005173 active site 885276005174 substrate binding site [chemical binding]; other site 885276005175 catalytic residue [active] 885276005176 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 885276005177 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 885276005178 dimer interface [polypeptide binding]; other site 885276005179 active site 885276005180 metal binding site [ion binding]; metal-binding site 885276005181 glutathione binding site [chemical binding]; other site 885276005182 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 885276005183 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 885276005184 dimer interface [polypeptide binding]; other site 885276005185 catalytic site [active] 885276005186 putative active site [active] 885276005187 putative substrate binding site [chemical binding]; other site 885276005188 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 885276005189 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 885276005190 putative GSH binding site [chemical binding]; other site 885276005191 catalytic residues [active] 885276005192 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 885276005193 NlpC/P60 family; Region: NLPC_P60; pfam00877 885276005194 superoxide dismutase; Provisional; Region: PRK10543 885276005195 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 885276005196 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 885276005197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005198 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276005199 putative substrate translocation pore; other site 885276005200 hypothetical protein; Provisional; Region: PRK14756 885276005201 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 885276005202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276005203 DNA binding site [nucleotide binding] 885276005204 domain linker motif; other site 885276005205 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 885276005206 dimerization interface [polypeptide binding]; other site 885276005207 ligand binding site [chemical binding]; other site 885276005208 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885276005209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276005210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276005211 dimerization interface [polypeptide binding]; other site 885276005212 putative transporter; Provisional; Region: PRK11043 885276005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005214 putative substrate translocation pore; other site 885276005215 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 885276005216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 885276005217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276005218 S-adenosylmethionine binding site [chemical binding]; other site 885276005219 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 885276005220 Lumazine binding domain; Region: Lum_binding; pfam00677 885276005221 Lumazine binding domain; Region: Lum_binding; pfam00677 885276005222 multidrug efflux protein; Reviewed; Region: PRK01766 885276005223 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 885276005224 cation binding site [ion binding]; other site 885276005225 hypothetical protein; Provisional; Region: PRK09945 885276005226 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885276005227 putative monooxygenase; Provisional; Region: PRK11118 885276005228 hypothetical protein; Provisional; Region: PRK09897 885276005229 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 885276005230 hypothetical protein; Provisional; Region: PRK09946 885276005231 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 885276005232 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 885276005233 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 885276005234 hypothetical protein; Provisional; Region: PRK09947 885276005235 putative oxidoreductase; Provisional; Region: PRK09849 885276005236 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 885276005237 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 885276005238 hypothetical protein; Provisional; Region: PRK09898 885276005239 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276005240 hypothetical protein; Provisional; Region: PRK10292 885276005241 pyruvate kinase; Provisional; Region: PRK09206 885276005242 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 885276005243 active site 885276005244 domain interfaces; other site 885276005245 murein lipoprotein; Provisional; Region: PRK15396 885276005246 L,D-transpeptidase; Provisional; Region: PRK10190 885276005247 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276005248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276005249 cysteine desufuration protein SufE; Provisional; Region: PRK09296 885276005250 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 885276005251 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 885276005252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276005253 catalytic residue [active] 885276005254 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 885276005255 FeS assembly protein SufD; Region: sufD; TIGR01981 885276005256 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 885276005257 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 885276005258 Walker A/P-loop; other site 885276005259 ATP binding site [chemical binding]; other site 885276005260 Q-loop/lid; other site 885276005261 ABC transporter signature motif; other site 885276005262 Walker B; other site 885276005263 D-loop; other site 885276005264 H-loop/switch region; other site 885276005265 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 885276005266 putative ABC transporter; Region: ycf24; CHL00085 885276005267 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 885276005268 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 885276005269 CoenzymeA binding site [chemical binding]; other site 885276005270 subunit interaction site [polypeptide binding]; other site 885276005271 PHB binding site; other site 885276005272 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 885276005273 FAD binding domain; Region: FAD_binding_4; pfam01565 885276005274 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 885276005275 putative inner membrane protein; Provisional; Region: PRK10983 885276005276 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885276005277 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 885276005278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276005280 putative substrate translocation pore; other site 885276005281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005282 putative substrate translocation pore; other site 885276005283 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 885276005284 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 885276005285 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 885276005286 shikimate binding site; other site 885276005287 NAD(P) binding site [chemical binding]; other site 885276005288 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 885276005289 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 885276005290 active site 885276005291 catalytic residue [active] 885276005292 dimer interface [polypeptide binding]; other site 885276005293 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 885276005294 Coenzyme A transferase; Region: CoA_trans; smart00882 885276005295 Coenzyme A transferase; Region: CoA_trans; cl17247 885276005296 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 885276005297 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 885276005298 active site 885276005299 Cupin domain; Region: Cupin_2; pfam07883 885276005300 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 885276005301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276005302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276005303 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 885276005304 Ligand binding site [chemical binding]; other site 885276005305 Electron transfer flavoprotein domain; Region: ETF; pfam01012 885276005306 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 885276005307 Electron transfer flavoprotein domain; Region: ETF; smart00893 885276005308 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 885276005309 oxidoreductase; Provisional; Region: PRK10015 885276005310 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 885276005311 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 885276005312 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 885276005313 acyl-activating enzyme (AAE) consensus motif; other site 885276005314 putative AMP binding site [chemical binding]; other site 885276005315 putative active site [active] 885276005316 putative CoA binding site [chemical binding]; other site 885276005317 phosphoenolpyruvate synthase; Validated; Region: PRK06464 885276005318 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 885276005319 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885276005320 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885276005321 PEP synthetase regulatory protein; Provisional; Region: PRK05339 885276005322 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 885276005323 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885276005324 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 885276005325 Uncharacterized conserved protein [Function unknown]; Region: COG0397 885276005326 hypothetical protein; Validated; Region: PRK00029 885276005327 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 885276005328 NlpC/P60 family; Region: NLPC_P60; pfam00877 885276005329 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 885276005330 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276005331 Walker A/P-loop; other site 885276005332 ATP binding site [chemical binding]; other site 885276005333 Q-loop/lid; other site 885276005334 ABC transporter signature motif; other site 885276005335 Walker B; other site 885276005336 D-loop; other site 885276005337 H-loop/switch region; other site 885276005338 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 885276005339 catalytic residues [active] 885276005340 dimer interface [polypeptide binding]; other site 885276005341 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885276005342 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276005343 ABC-ATPase subunit interface; other site 885276005344 dimer interface [polypeptide binding]; other site 885276005345 putative PBP binding regions; other site 885276005346 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885276005347 IHF dimer interface [polypeptide binding]; other site 885276005348 IHF - DNA interface [nucleotide binding]; other site 885276005349 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 885276005350 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 885276005351 putative tRNA-binding site [nucleotide binding]; other site 885276005352 B3/4 domain; Region: B3_4; pfam03483 885276005353 tRNA synthetase B5 domain; Region: B5; smart00874 885276005354 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 885276005355 dimer interface [polypeptide binding]; other site 885276005356 motif 1; other site 885276005357 motif 3; other site 885276005358 motif 2; other site 885276005359 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 885276005360 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 885276005361 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 885276005362 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 885276005363 dimer interface [polypeptide binding]; other site 885276005364 motif 1; other site 885276005365 active site 885276005366 motif 2; other site 885276005367 motif 3; other site 885276005368 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 885276005369 23S rRNA binding site [nucleotide binding]; other site 885276005370 L21 binding site [polypeptide binding]; other site 885276005371 L13 binding site [polypeptide binding]; other site 885276005372 carbamoyl-phosphate synthase (glutamine-hydrolyzing); Region: PLN02771 885276005373 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 885276005374 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 885276005375 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 885276005376 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 885276005377 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 885276005378 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 885276005379 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 885276005380 active site 885276005381 dimer interface [polypeptide binding]; other site 885276005382 motif 1; other site 885276005383 motif 2; other site 885276005384 motif 3; other site 885276005385 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 885276005386 anticodon binding site; other site 885276005387 potential frameshift: common BLAST hit: gi|254793337|ref|YP_003078174.1| non-LEE-encoded type III effector 885276005388 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 885276005389 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 885276005390 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 885276005391 6-phosphofructokinase 2; Provisional; Region: PRK10294 885276005392 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 885276005393 putative substrate binding site [chemical binding]; other site 885276005394 putative ATP binding site [chemical binding]; other site 885276005395 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 885276005396 Phosphotransferase enzyme family; Region: APH; pfam01636 885276005397 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 885276005398 active site 885276005399 ATP binding site [chemical binding]; other site 885276005400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 885276005401 YniB-like protein; Region: YniB; pfam14002 885276005402 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 885276005403 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 885276005404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276005405 motif II; other site 885276005406 inner membrane protein; Provisional; Region: PRK11648 885276005407 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 885276005408 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885276005409 cell division modulator; Provisional; Region: PRK10113 885276005410 hydroperoxidase II; Provisional; Region: katE; PRK11249 885276005411 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 885276005412 tetramer interface [polypeptide binding]; other site 885276005413 heme binding pocket [chemical binding]; other site 885276005414 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 885276005415 domain interactions; other site 885276005416 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 885276005417 putative active site [active] 885276005418 YdjC motif; other site 885276005419 Mg binding site [ion binding]; other site 885276005420 putative homodimer interface [polypeptide binding]; other site 885276005421 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 885276005422 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 885276005423 NAD binding site [chemical binding]; other site 885276005424 sugar binding site [chemical binding]; other site 885276005425 divalent metal binding site [ion binding]; other site 885276005426 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885276005427 dimer interface [polypeptide binding]; other site 885276005428 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 885276005429 Cupin domain; Region: Cupin_2; pfam07883 885276005430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276005431 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 885276005432 methionine cluster; other site 885276005433 active site 885276005434 phosphorylation site [posttranslational modification] 885276005435 metal binding site [ion binding]; metal-binding site 885276005436 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 885276005437 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 885276005438 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 885276005439 active site 885276005440 P-loop; other site 885276005441 phosphorylation site [posttranslational modification] 885276005442 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 885276005443 NAD+ synthetase; Region: nadE; TIGR00552 885276005444 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 885276005445 homodimer interface [polypeptide binding]; other site 885276005446 NAD binding pocket [chemical binding]; other site 885276005447 ATP binding pocket [chemical binding]; other site 885276005448 Mg binding site [ion binding]; other site 885276005449 active-site loop [active] 885276005450 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 885276005451 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 885276005452 GIY-YIG motif/motif A; other site 885276005453 active site 885276005454 catalytic site [active] 885276005455 putative DNA binding site [nucleotide binding]; other site 885276005456 metal binding site [ion binding]; metal-binding site 885276005457 hypothetical protein; Provisional; Region: PRK11396 885276005458 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 885276005459 dimer interface [polypeptide binding]; other site 885276005460 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 885276005461 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 885276005462 putative active site [active] 885276005463 Zn binding site [ion binding]; other site 885276005464 succinylarginine dihydrolase; Provisional; Region: PRK13281 885276005465 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 885276005466 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 885276005467 NAD(P) binding site [chemical binding]; other site 885276005468 catalytic residues [active] 885276005469 arginine succinyltransferase; Provisional; Region: PRK10456 885276005470 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 885276005471 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 885276005472 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885276005473 inhibitor-cofactor binding pocket; inhibition site 885276005474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276005475 catalytic residue [active] 885276005476 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 885276005477 putative catalytic site [active] 885276005478 putative phosphate binding site [ion binding]; other site 885276005479 active site 885276005480 metal binding site A [ion binding]; metal-binding site 885276005481 DNA binding site [nucleotide binding] 885276005482 putative AP binding site [nucleotide binding]; other site 885276005483 putative metal binding site B [ion binding]; other site 885276005484 Uncharacterized conserved protein [Function unknown]; Region: COG0398 885276005485 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885276005486 Uncharacterized conserved protein [Function unknown]; Region: COG0398 885276005487 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885276005488 Uncharacterized conserved protein [Function unknown]; Region: COG2128 885276005489 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 885276005490 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 885276005491 hypothetical protein; Provisional; Region: PRK11622 885276005492 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 885276005493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276005494 dimer interface [polypeptide binding]; other site 885276005495 conserved gate region; other site 885276005496 putative PBP binding loops; other site 885276005497 ABC-ATPase subunit interface; other site 885276005498 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 885276005499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276005500 Walker A/P-loop; other site 885276005501 ATP binding site [chemical binding]; other site 885276005502 Q-loop/lid; other site 885276005503 ABC transporter signature motif; other site 885276005504 Walker B; other site 885276005505 D-loop; other site 885276005506 H-loop/switch region; other site 885276005507 Rhodanese Homology Domain; Region: RHOD; smart00450 885276005508 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 885276005509 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 885276005510 active site residue [active] 885276005511 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 885276005512 active site residue [active] 885276005513 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 885276005514 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 885276005515 active site 885276005516 8-oxo-dGMP binding site [chemical binding]; other site 885276005517 nudix motif; other site 885276005518 metal binding site [ion binding]; metal-binding site 885276005519 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 885276005520 glutamate dehydrogenase; Provisional; Region: PRK09414 885276005521 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 885276005522 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 885276005523 NAD(P) binding site [chemical binding]; other site 885276005524 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 885276005525 HSP70 interaction site [polypeptide binding]; other site 885276005526 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885276005527 Sel1-like repeats; Region: SEL1; smart00671 885276005528 Sel1-like repeats; Region: SEL1; smart00671 885276005529 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885276005530 Sel1-like repeats; Region: SEL1; smart00671 885276005531 Sel1-like repeats; Region: SEL1; smart00671 885276005532 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 885276005533 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 885276005534 nucleotide binding site [chemical binding]; other site 885276005535 putative NEF/HSP70 interaction site [polypeptide binding]; other site 885276005536 SBD interface [polypeptide binding]; other site 885276005537 DNA topoisomerase III; Provisional; Region: PRK07726 885276005538 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 885276005539 active site 885276005540 putative interdomain interaction site [polypeptide binding]; other site 885276005541 putative metal-binding site [ion binding]; other site 885276005542 putative nucleotide binding site [chemical binding]; other site 885276005543 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 885276005544 domain I; other site 885276005545 DNA binding groove [nucleotide binding] 885276005546 phosphate binding site [ion binding]; other site 885276005547 domain II; other site 885276005548 domain III; other site 885276005549 nucleotide binding site [chemical binding]; other site 885276005550 catalytic site [active] 885276005551 domain IV; other site 885276005552 selenophosphate synthetase; Provisional; Region: PRK00943 885276005553 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 885276005554 dimerization interface [polypeptide binding]; other site 885276005555 putative ATP binding site [chemical binding]; other site 885276005556 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 885276005557 putative FMN binding site [chemical binding]; other site 885276005558 protease 4; Provisional; Region: PRK10949 885276005559 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 885276005560 tandem repeat interface [polypeptide binding]; other site 885276005561 oligomer interface [polypeptide binding]; other site 885276005562 active site residues [active] 885276005563 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 885276005564 tandem repeat interface [polypeptide binding]; other site 885276005565 oligomer interface [polypeptide binding]; other site 885276005566 active site residues [active] 885276005567 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 885276005568 active site 885276005569 homodimer interface [polypeptide binding]; other site 885276005570 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 885276005571 Isochorismatase family; Region: Isochorismatase; pfam00857 885276005572 catalytic triad [active] 885276005573 metal binding site [ion binding]; metal-binding site 885276005574 conserved cis-peptide bond; other site 885276005575 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 885276005576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005577 putative substrate translocation pore; other site 885276005578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005579 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276005580 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276005581 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276005582 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276005583 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276005584 active site 885276005585 catalytic tetrad [active] 885276005586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276005587 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885276005588 substrate binding site [chemical binding]; other site 885276005589 ATP binding site [chemical binding]; other site 885276005590 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885276005591 intersubunit interface [polypeptide binding]; other site 885276005592 active site 885276005593 zinc binding site [ion binding]; other site 885276005594 Na+ binding site [ion binding]; other site 885276005595 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276005596 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 885276005597 inhibitor binding site; inhibition site 885276005598 catalytic Zn binding site [ion binding]; other site 885276005599 structural Zn binding site [ion binding]; other site 885276005600 NADP binding site [chemical binding]; other site 885276005601 tetramer interface [polypeptide binding]; other site 885276005602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005604 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276005605 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 885276005606 putative NAD(P) binding site [chemical binding]; other site 885276005607 catalytic Zn binding site [ion binding]; other site 885276005608 structural Zn binding site [ion binding]; other site 885276005609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 885276005610 methionine sulfoxide reductase B; Provisional; Region: PRK00222 885276005611 SelR domain; Region: SelR; pfam01641 885276005612 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 885276005613 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 885276005614 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 885276005615 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 885276005616 active site 885276005617 phosphate binding residues; other site 885276005618 catalytic residues [active] 885276005619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276005620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276005621 active site 885276005622 catalytic tetrad [active] 885276005623 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 885276005624 PrkA family serine protein kinase; Provisional; Region: PRK15455 885276005625 AAA ATPase domain; Region: AAA_16; pfam13191 885276005626 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 885276005627 hypothetical protein; Provisional; Region: PRK05325 885276005628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276005629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276005630 metal binding site [ion binding]; metal-binding site 885276005631 active site 885276005632 I-site; other site 885276005633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276005634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276005635 metal binding site [ion binding]; metal-binding site 885276005636 active site 885276005637 I-site; other site 885276005638 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 885276005639 putative deacylase active site [active] 885276005640 Predicted membrane protein [Function unknown]; Region: COG2707 885276005641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276005642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276005643 cyanate transporter; Region: CynX; TIGR00896 885276005644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005645 Uncharacterized conserved protein [Function unknown]; Region: COG3189 885276005646 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 885276005647 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 885276005648 Domain of unknown function (DUF333); Region: DUF333; pfam03891 885276005649 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 885276005650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885276005651 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276005652 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276005653 metal binding site [ion binding]; metal-binding site 885276005654 active site 885276005655 I-site; other site 885276005656 hypothetical protein; Provisional; Region: PRK10457 885276005657 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 885276005658 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 885276005659 leucine export protein LeuE; Provisional; Region: PRK10958 885276005660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276005661 ribonuclease D; Provisional; Region: PRK10829 885276005662 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 885276005663 catalytic site [active] 885276005664 putative active site [active] 885276005665 putative substrate binding site [chemical binding]; other site 885276005666 Helicase and RNase D C-terminal; Region: HRDC; smart00341 885276005667 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 885276005668 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 885276005669 acyl-activating enzyme (AAE) consensus motif; other site 885276005670 putative AMP binding site [chemical binding]; other site 885276005671 putative active site [active] 885276005672 putative CoA binding site [chemical binding]; other site 885276005673 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 885276005674 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 885276005675 Glycoprotease family; Region: Peptidase_M22; pfam00814 885276005676 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 885276005677 DEAD/DEAH box helicase; Region: DEAD; pfam00270 885276005678 DEAD_2; Region: DEAD_2; pfam06733 885276005679 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 885276005680 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 885276005681 homotrimer interaction site [polypeptide binding]; other site 885276005682 putative active site [active] 885276005683 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 885276005684 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 885276005685 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 885276005686 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 885276005687 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 885276005688 putative active site [active] 885276005689 putative CoA binding site [chemical binding]; other site 885276005690 nudix motif; other site 885276005691 metal binding site [ion binding]; metal-binding site 885276005692 L-serine deaminase; Provisional; Region: PRK15023 885276005693 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 885276005694 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 885276005695 phage resistance protein; Provisional; Region: PRK10551 885276005696 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885276005697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276005698 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885276005699 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 885276005700 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885276005701 Transporter associated domain; Region: CorC_HlyC; smart01091 885276005702 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 885276005703 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885276005704 active pocket/dimerization site; other site 885276005705 active site 885276005706 phosphorylation site [posttranslational modification] 885276005707 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885276005708 active site 885276005709 phosphorylation site [posttranslational modification] 885276005710 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 885276005711 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 885276005712 Predicted membrane protein [Function unknown]; Region: COG4811 885276005713 hypothetical protein; Provisional; Region: PRK11469 885276005714 Domain of unknown function DUF; Region: DUF204; pfam02659 885276005715 Domain of unknown function DUF; Region: DUF204; pfam02659 885276005716 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 885276005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276005718 S-adenosylmethionine binding site [chemical binding]; other site 885276005719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885276005720 DNA-binding site [nucleotide binding]; DNA binding site 885276005721 RNA-binding motif; other site 885276005722 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 885276005723 YebO-like protein; Region: YebO; pfam13974 885276005724 PhoPQ regulatory protein; Provisional; Region: PRK10299 885276005725 YobH-like protein; Region: YobH; pfam13996 885276005726 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 885276005727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276005728 dimerization interface [polypeptide binding]; other site 885276005729 putative Zn2+ binding site [ion binding]; other site 885276005730 putative DNA binding site [nucleotide binding]; other site 885276005731 Bacterial transcriptional regulator; Region: IclR; pfam01614 885276005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276005733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276005734 putative substrate translocation pore; other site 885276005735 Predicted integral membrane protein [Function unknown]; Region: COG5521 885276005736 heat shock protein HtpX; Provisional; Region: PRK05457 885276005737 carboxy-terminal protease; Provisional; Region: PRK11186 885276005738 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 885276005739 protein binding site [polypeptide binding]; other site 885276005740 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 885276005741 Catalytic dyad [active] 885276005742 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 885276005743 ProP expression regulator; Provisional; Region: PRK04950 885276005744 ProQ/FINO family; Region: ProQ; pfam04352 885276005745 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 885276005746 GAF domain; Region: GAF_2; pfam13185 885276005747 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 885276005748 Paraquat-inducible protein A; Region: PqiA; pfam04403 885276005749 Paraquat-inducible protein A; Region: PqiA; pfam04403 885276005750 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 885276005751 mce related protein; Region: MCE; pfam02470 885276005752 mce related protein; Region: MCE; pfam02470 885276005753 mce related protein; Region: MCE; pfam02470 885276005754 mce related protein; Region: MCE; pfam02470 885276005755 mce related protein; Region: MCE; pfam02470 885276005756 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 885276005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276005758 S-adenosylmethionine binding site [chemical binding]; other site 885276005759 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 885276005760 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 885276005761 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 885276005762 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 885276005763 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885276005764 active site 885276005765 metal binding site [ion binding]; metal-binding site 885276005766 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 885276005767 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 885276005768 hypothetical protein; Provisional; Region: PRK10301 885276005769 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 885276005770 Predicted amidohydrolase [General function prediction only]; Region: COG0388 885276005771 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 885276005772 exodeoxyribonuclease X; Provisional; Region: PRK07983 885276005773 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 885276005774 active site 885276005775 catalytic site [active] 885276005776 substrate binding site [chemical binding]; other site 885276005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 885276005778 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 885276005779 putative metal binding site [ion binding]; other site 885276005780 hypothetical protein; Provisional; Region: PRK13680 885276005781 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 885276005782 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 885276005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885276005784 ATP-grasp domain; Region: ATP-grasp; pfam02222 885276005785 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 885276005786 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 885276005787 active site 885276005788 intersubunit interface [polypeptide binding]; other site 885276005789 catalytic residue [active] 885276005790 phosphogluconate dehydratase; Validated; Region: PRK09054 885276005791 6-phosphogluconate dehydratase; Region: edd; TIGR01196 885276005792 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 885276005793 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 885276005794 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 885276005795 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 885276005796 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885276005797 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885276005798 putative active site [active] 885276005799 pyruvate kinase; Provisional; Region: PRK05826 885276005800 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 885276005801 domain interfaces; other site 885276005802 active site 885276005803 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 885276005804 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885276005805 putative acyl-acceptor binding pocket; other site 885276005806 putative peptidase; Provisional; Region: PRK11649 885276005807 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 885276005808 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276005809 Peptidase family M23; Region: Peptidase_M23; pfam01551 885276005810 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 885276005811 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 885276005812 metal binding site [ion binding]; metal-binding site 885276005813 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 885276005814 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 885276005815 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 885276005816 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276005817 ABC-ATPase subunit interface; other site 885276005818 dimer interface [polypeptide binding]; other site 885276005819 putative PBP binding regions; other site 885276005820 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 885276005821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276005822 Walker A motif; other site 885276005823 ATP binding site [chemical binding]; other site 885276005824 Walker B motif; other site 885276005825 arginine finger; other site 885276005826 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 885276005827 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 885276005828 RuvA N terminal domain; Region: RuvA_N; pfam01330 885276005829 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 885276005830 hypothetical protein; Provisional; Region: PRK11470 885276005831 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 885276005832 active site 885276005833 putative DNA-binding cleft [nucleotide binding]; other site 885276005834 dimer interface [polypeptide binding]; other site 885276005835 hypothetical protein; Validated; Region: PRK00110 885276005836 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 885276005837 nudix motif; other site 885276005838 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 885276005839 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 885276005840 dimer interface [polypeptide binding]; other site 885276005841 anticodon binding site; other site 885276005842 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 885276005843 homodimer interface [polypeptide binding]; other site 885276005844 motif 1; other site 885276005845 active site 885276005846 motif 2; other site 885276005847 GAD domain; Region: GAD; pfam02938 885276005848 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 885276005849 motif 3; other site 885276005850 Isochorismatase family; Region: Isochorismatase; pfam00857 885276005851 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 885276005852 catalytic triad [active] 885276005853 conserved cis-peptide bond; other site 885276005854 hypothetical protein; Provisional; Region: PRK10302 885276005855 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 885276005856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276005857 S-adenosylmethionine binding site [chemical binding]; other site 885276005858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276005859 S-adenosylmethionine binding site [chemical binding]; other site 885276005860 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885276005861 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 885276005862 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 885276005863 molybdopterin cofactor binding site [chemical binding]; other site 885276005864 substrate binding site [chemical binding]; other site 885276005865 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 885276005866 molybdopterin cofactor binding site; other site 885276005867 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 885276005868 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 885276005869 copper homeostasis protein CutC; Provisional; Region: PRK11572 885276005870 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 885276005871 putative metal binding site [ion binding]; other site 885276005872 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 885276005873 arginyl-tRNA synthetase; Region: argS; TIGR00456 885276005874 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 885276005875 active site 885276005876 HIGH motif; other site 885276005877 KMSK motif region; other site 885276005878 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 885276005879 tRNA binding surface [nucleotide binding]; other site 885276005880 anticodon binding site; other site 885276005881 Flagellar protein FlhE; Region: FlhE; pfam06366 885276005882 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 885276005883 FHIPEP family; Region: FHIPEP; pfam00771 885276005884 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 885276005885 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 885276005886 chemotaxis regulator CheZ; Provisional; Region: PRK11166 885276005887 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 885276005888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276005889 active site 885276005890 phosphorylation site [posttranslational modification] 885276005891 intermolecular recognition site; other site 885276005892 dimerization interface [polypeptide binding]; other site 885276005893 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 885276005894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276005895 active site 885276005896 phosphorylation site [posttranslational modification] 885276005897 intermolecular recognition site; other site 885276005898 dimerization interface [polypeptide binding]; other site 885276005899 CheB methylesterase; Region: CheB_methylest; pfam01339 885276005900 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 885276005901 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 885276005902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276005903 S-adenosylmethionine binding site [chemical binding]; other site 885276005904 potential frameshift: common BLAST hit: gi|383177867|ref|YP_005455872.1| methyl-accepting protein IV 885276005905 methyl-accepting protein IV; Provisional; Region: PRK09793 885276005906 methyl-accepting protein IV; Provisional; Region: PRK09793 885276005907 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 885276005908 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 885276005909 dimer interface [polypeptide binding]; other site 885276005910 ligand binding site [chemical binding]; other site 885276005911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276005912 dimerization interface [polypeptide binding]; other site 885276005913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885276005914 dimer interface [polypeptide binding]; other site 885276005915 putative CheW interface [polypeptide binding]; other site 885276005916 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 885276005917 putative CheA interaction surface; other site 885276005918 chemotaxis protein CheA; Provisional; Region: PRK10547 885276005919 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885276005920 putative binding surface; other site 885276005921 active site 885276005922 CheY binding; Region: CheY-binding; pfam09078 885276005923 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 885276005924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276005925 ATP binding site [chemical binding]; other site 885276005926 Mg2+ binding site [ion binding]; other site 885276005927 G-X-G motif; other site 885276005928 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 885276005929 flagellar motor protein MotB; Validated; Region: motB; PRK09041 885276005930 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 885276005931 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276005932 ligand binding site [chemical binding]; other site 885276005933 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 885276005934 flagellar motor protein MotA; Validated; Region: PRK09110 885276005935 transcriptional activator FlhC; Provisional; Region: PRK12722 885276005936 transcriptional activator FlhD; Provisional; Region: PRK02909 885276005937 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276005938 Ligand Binding Site [chemical binding]; other site 885276005939 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 885276005940 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 885276005941 active site 885276005942 homotetramer interface [polypeptide binding]; other site 885276005943 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 885276005944 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 885276005945 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276005946 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276005947 TM-ABC transporter signature motif; other site 885276005948 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 885276005949 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276005950 Walker A/P-loop; other site 885276005951 ATP binding site [chemical binding]; other site 885276005952 Q-loop/lid; other site 885276005953 ABC transporter signature motif; other site 885276005954 Walker B; other site 885276005955 D-loop; other site 885276005956 H-loop/switch region; other site 885276005957 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276005958 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 885276005959 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 885276005960 ligand binding site [chemical binding]; other site 885276005961 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 885276005962 Ferritin-like domain; Region: Ferritin; pfam00210 885276005963 ferroxidase diiron center [ion binding]; other site 885276005964 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 885276005965 YecR-like lipoprotein; Region: YecR; pfam13992 885276005966 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 885276005967 Ferritin-like domain; Region: Ferritin; pfam00210 885276005968 ferroxidase diiron center [ion binding]; other site 885276005969 probable metal-binding protein; Region: matur_matur; TIGR03853 885276005970 tyrosine transporter TyrP; Provisional; Region: PRK15132 885276005971 aromatic amino acid transport protein; Region: araaP; TIGR00837 885276005972 hypothetical protein; Provisional; Region: PRK10396 885276005973 yecA family protein; Region: ygfB_yecA; TIGR02292 885276005974 SEC-C motif; Region: SEC-C; pfam02810 885276005975 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 885276005976 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 885276005977 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 885276005978 GIY-YIG motif/motif A; other site 885276005979 active site 885276005980 catalytic site [active] 885276005981 putative DNA binding site [nucleotide binding]; other site 885276005982 metal binding site [ion binding]; metal-binding site 885276005983 UvrB/uvrC motif; Region: UVR; pfam02151 885276005984 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 885276005985 Helix-hairpin-helix motif; Region: HHH; pfam00633 885276005986 response regulator; Provisional; Region: PRK09483 885276005987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276005988 active site 885276005989 phosphorylation site [posttranslational modification] 885276005990 intermolecular recognition site; other site 885276005991 dimerization interface [polypeptide binding]; other site 885276005992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276005993 DNA binding residues [nucleotide binding] 885276005994 dimerization interface [polypeptide binding]; other site 885276005995 hypothetical protein; Provisional; Region: PRK10613 885276005996 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 885276005997 Autoinducer binding domain; Region: Autoind_bind; pfam03472 885276005998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276005999 DNA binding residues [nucleotide binding] 885276006000 dimerization interface [polypeptide binding]; other site 885276006001 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 885276006002 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885276006003 Walker A/P-loop; other site 885276006004 ATP binding site [chemical binding]; other site 885276006005 Q-loop/lid; other site 885276006006 ABC transporter signature motif; other site 885276006007 Walker B; other site 885276006008 D-loop; other site 885276006009 H-loop/switch region; other site 885276006010 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276006011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276006012 dimer interface [polypeptide binding]; other site 885276006013 conserved gate region; other site 885276006014 putative PBP binding loops; other site 885276006015 ABC-ATPase subunit interface; other site 885276006016 D-cysteine desulfhydrase; Validated; Region: PRK03910 885276006017 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 885276006018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276006019 catalytic residue [active] 885276006020 cystine transporter subunit; Provisional; Region: PRK11260 885276006021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276006022 substrate binding pocket [chemical binding]; other site 885276006023 membrane-bound complex binding site; other site 885276006024 hinge residues; other site 885276006025 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 885276006026 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 885276006027 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885276006028 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 885276006029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885276006030 DNA binding residues [nucleotide binding] 885276006031 flagellin; Validated; Region: PRK08026 885276006032 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 885276006033 Flagellin protein; Region: FliC; pfam12445 885276006034 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 885276006035 flagellar capping protein; Reviewed; Region: fliD; PRK08032 885276006036 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 885276006037 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 885276006038 Flagellar protein FliS; Region: FliS; cl00654 885276006039 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 885276006040 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 885276006041 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 885276006042 active site 885276006043 Na/Ca binding site [ion binding]; other site 885276006044 catalytic site [active] 885276006045 lipoprotein; Provisional; Region: PRK10397 885276006046 putative inner membrane protein; Provisional; Region: PRK11099 885276006047 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 885276006048 CPxP motif; other site 885276006049 hypothetical protein; Provisional; Region: PRK09951 885276006050 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276006051 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276006052 trimer interface [polypeptide binding]; other site 885276006053 eyelet of channel; other site 885276006054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276006055 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 885276006056 substrate binding site [chemical binding]; other site 885276006057 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 885276006058 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 885276006059 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 885276006060 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 885276006061 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 885276006062 flagellar motor switch protein FliG; Region: fliG; TIGR00207 885276006063 FliG C-terminal domain; Region: FliG_C; pfam01706 885276006064 flagellar assembly protein H; Validated; Region: fliH; PRK05687 885276006065 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 885276006066 Flagellar assembly protein FliH; Region: FliH; pfam02108 885276006067 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 885276006068 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 885276006069 Walker A motif/ATP binding site; other site 885276006070 Walker B motif; other site 885276006071 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 885276006072 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 885276006073 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 885276006074 flagellar hook-length control protein; Provisional; Region: PRK10118 885276006075 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 885276006076 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 885276006077 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 885276006078 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 885276006079 flagellar motor switch protein; Validated; Region: fliN; PRK05698 885276006080 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 885276006081 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 885276006082 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 885276006083 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 885276006084 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 885276006085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276006086 DNA binding residues [nucleotide binding] 885276006087 dimerization interface [polypeptide binding]; other site 885276006088 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 885276006089 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 885276006090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276006091 active site 885276006092 motif I; other site 885276006093 motif II; other site 885276006094 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 885276006095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276006096 metal binding site [ion binding]; metal-binding site 885276006097 active site 885276006098 I-site; other site 885276006099 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 885276006100 hypothetical protein; Provisional; Region: PRK10062 885276006101 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 885276006102 EamA-like transporter family; Region: EamA; pfam00892 885276006103 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 885276006104 additional DNA contacts [nucleotide binding]; other site 885276006105 mismatch recognition site; other site 885276006106 active site 885276006107 zinc binding site [ion binding]; other site 885276006108 DNA intercalation site [nucleotide binding]; other site 885276006109 DNA cytosine methylase; Provisional; Region: PRK10458 885276006110 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 885276006111 cofactor binding site; other site 885276006112 DNA binding site [nucleotide binding] 885276006113 substrate interaction site [chemical binding]; other site 885276006114 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 885276006115 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885276006116 Zn2+ binding site [ion binding]; other site 885276006117 Mg2+ binding site [ion binding]; other site 885276006118 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 885276006119 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276006120 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276006121 trimer interface [polypeptide binding]; other site 885276006122 eyelet of channel; other site 885276006123 chaperone protein HchA; Provisional; Region: PRK04155 885276006124 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 885276006125 dimer interface [polypeptide binding]; other site 885276006126 metal binding site [ion binding]; metal-binding site 885276006127 potential oxyanion hole; other site 885276006128 potential catalytic triad [active] 885276006129 conserved cys residue [active] 885276006130 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 885276006131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276006132 dimer interface [polypeptide binding]; other site 885276006133 phosphorylation site [posttranslational modification] 885276006134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276006135 ATP binding site [chemical binding]; other site 885276006136 Mg2+ binding site [ion binding]; other site 885276006137 G-X-G motif; other site 885276006138 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 885276006139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276006140 active site 885276006141 phosphorylation site [posttranslational modification] 885276006142 intermolecular recognition site; other site 885276006143 dimerization interface [polypeptide binding]; other site 885276006144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276006145 DNA binding site [nucleotide binding] 885276006146 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 885276006147 active site 885276006148 homotetramer interface [polypeptide binding]; other site 885276006149 TMAO/DMSO reductase; Reviewed; Region: PRK05363 885276006150 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 885276006151 Moco binding site; other site 885276006152 metal coordination site [ion binding]; other site 885276006153 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 885276006154 zinc/cadmium-binding protein; Provisional; Region: PRK10306 885276006155 integrase; Provisional; Region: PRK09692 885276006156 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276006157 active site 885276006158 Int/Topo IB signature motif; other site 885276006159 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 885276006160 PilS N terminal; Region: PilS; pfam08805 885276006161 Conjugal transfer protein TraD; Region: TraD; pfam06412 885276006162 MobA/MobL family; Region: MobA_MobL; pfam03389 885276006163 TIR domain; Region: TIR_2; pfam13676 885276006164 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 885276006165 potential frameshift: common BLAST hit: gi|207857426|ref|YP_002244077.1| exported protein 885276006166 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 885276006167 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 885276006168 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 885276006169 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 885276006170 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 885276006171 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 885276006172 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 885276006173 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276006174 active site 885276006175 Int/Topo IB signature motif; other site 885276006176 salicylate synthase Irp9; Reviewed; Region: PRK06772 885276006177 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 885276006178 muropeptide transporter; Validated; Region: ampG; cl17669 885276006179 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 885276006180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276006181 Walker A/P-loop; other site 885276006182 ATP binding site [chemical binding]; other site 885276006183 Q-loop/lid; other site 885276006184 ABC transporter signature motif; other site 885276006185 Walker B; other site 885276006186 D-loop; other site 885276006187 H-loop/switch region; other site 885276006188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 885276006189 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 885276006190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276006191 Walker A/P-loop; other site 885276006192 ATP binding site [chemical binding]; other site 885276006193 Q-loop/lid; other site 885276006194 ABC transporter signature motif; other site 885276006195 Walker B; other site 885276006196 D-loop; other site 885276006197 H-loop/switch region; other site 885276006198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276006199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276006200 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 885276006201 Condensation domain; Region: Condensation; pfam00668 885276006202 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006203 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885276006204 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 885276006205 acyl-activating enzyme (AAE) consensus motif; other site 885276006206 AMP binding site [chemical binding]; other site 885276006207 Methyltransferase domain; Region: Methyltransf_23; pfam13489 885276006208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276006209 S-adenosylmethionine binding site [chemical binding]; other site 885276006210 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885276006211 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006212 Condensation domain; Region: Condensation; pfam00668 885276006213 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006214 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885276006215 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006216 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885276006217 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885276006218 active site 885276006219 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885276006220 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 885276006221 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885276006222 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 885276006223 KR domain; Region: KR; pfam08659 885276006224 NADP binding site [chemical binding]; other site 885276006225 active site 885276006226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006227 Condensation domain; Region: Condensation; pfam00668 885276006228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006229 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885276006230 Methyltransferase domain; Region: Methyltransf_12; pfam08242 885276006231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006232 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 885276006233 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 885276006234 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885276006235 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 885276006236 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 885276006237 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 885276006238 acyl-activating enzyme (AAE) consensus motif; other site 885276006239 active site 885276006240 AMP binding site [chemical binding]; other site 885276006241 substrate binding site [chemical binding]; other site 885276006242 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885276006243 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276006244 N-terminal plug; other site 885276006245 ligand-binding site [chemical binding]; other site 885276006246 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885276006247 potential frameshift: common BLAST hit: gi|117624169|ref|YP_853082.1| autotransporter 885276006248 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 885276006249 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 885276006250 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 885276006251 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 885276006252 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 885276006253 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 885276006254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885276006255 shikimate transporter; Provisional; Region: PRK09952 885276006256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276006257 putative substrate translocation pore; other site 885276006258 AMP nucleosidase; Provisional; Region: PRK08292 885276006259 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 885276006260 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 885276006261 hypothetical protein; Provisional; Region: PRK12378 885276006262 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 885276006263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276006264 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 885276006265 putative dimerization interface [polypeptide binding]; other site 885276006266 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 885276006267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276006268 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 885276006269 putative substrate binding site [chemical binding]; other site 885276006270 dimerization interface [polypeptide binding]; other site 885276006271 MATE family multidrug exporter; Provisional; Region: PRK10189 885276006272 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 885276006273 integrase; Provisional; Region: PRK09692 885276006274 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276006275 active site 885276006276 Int/Topo IB signature motif; other site 885276006277 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 885276006278 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 885276006279 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 885276006280 Beta-lactamase; Region: Beta-lactamase; pfam00144 885276006281 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885276006282 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885276006283 active site 885276006284 Condensation domain; Region: Condensation; pfam00668 885276006285 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885276006286 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 885276006287 acyl-activating enzyme (AAE) consensus motif; other site 885276006288 AMP binding site [chemical binding]; other site 885276006289 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006290 Condensation domain; Region: Condensation; pfam00668 885276006291 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 885276006292 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 885276006293 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 885276006294 amidase; Provisional; Region: PRK06170 885276006295 Amidase; Region: Amidase; cl11426 885276006296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885276006297 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885276006298 active site 885276006299 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006300 Condensation domain; Region: Condensation; pfam00668 885276006301 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006302 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885276006303 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 885276006304 acyl-activating enzyme (AAE) consensus motif; other site 885276006305 AMP binding site [chemical binding]; other site 885276006306 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 885276006307 putative FMN binding site [chemical binding]; other site 885276006308 NADPH bind site [chemical binding]; other site 885276006309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 885276006310 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006311 Condensation domain; Region: Condensation; pfam00668 885276006312 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006313 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 885276006314 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 885276006315 acyl-activating enzyme (AAE) consensus motif; other site 885276006316 AMP binding site [chemical binding]; other site 885276006317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006318 Condensation domain; Region: Condensation; pfam00668 885276006319 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006320 Nonribosomal peptide synthase; Region: NRPS; pfam08415 885276006321 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 885276006322 acyl-activating enzyme (AAE) consensus motif; other site 885276006323 AMP binding site [chemical binding]; other site 885276006324 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006325 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885276006326 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885276006327 active site 885276006328 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 885276006329 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885276006330 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885276006332 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 885276006333 acyl-activating enzyme (AAE) consensus motif; other site 885276006334 AMP binding site [chemical binding]; other site 885276006335 Condensation domain; Region: Condensation; pfam00668 885276006336 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006337 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 885276006338 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 885276006339 acyl-activating enzyme (AAE) consensus motif; other site 885276006340 AMP binding site [chemical binding]; other site 885276006341 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006342 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 885276006343 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885276006344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 885276006345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 885276006346 active site 885276006347 acyl carrier protein; Provisional; Region: PRK07081 885276006348 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 885276006349 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 885276006350 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885276006351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885276006352 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885276006353 active site 885276006354 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006355 Condensation domain; Region: Condensation; pfam00668 885276006356 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 885276006357 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 885276006358 acyl-activating enzyme (AAE) consensus motif; other site 885276006359 AMP binding site [chemical binding]; other site 885276006360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006361 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 885276006362 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 885276006363 active site 885276006364 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 885276006365 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 885276006366 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 885276006367 KR domain; Region: KR; pfam08659 885276006368 putative NADP binding site [chemical binding]; other site 885276006369 active site 885276006370 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 885276006371 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 885276006372 Enoylreductase; Region: PKS_ER; smart00829 885276006373 NAD(P) binding site [chemical binding]; other site 885276006374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276006375 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 885276006376 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 885276006377 DNA-binding interface [nucleotide binding]; DNA binding site 885276006378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 885276006379 Integrase core domain; Region: rve; pfam00665 885276006380 Integrase core domain; Region: rve_3; pfam13683 885276006381 Integrase core domain; Region: rve_2; pfam13333 885276006382 L,D-transpeptidase; Provisional; Region: PRK10190 885276006383 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 885276006384 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 885276006385 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 885276006386 putative dimer interface [polypeptide binding]; other site 885276006387 active site pocket [active] 885276006388 putative cataytic base [active] 885276006389 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 885276006390 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 885276006391 homotrimer interface [polypeptide binding]; other site 885276006392 Walker A motif; other site 885276006393 GTP binding site [chemical binding]; other site 885276006394 Walker B motif; other site 885276006395 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 885276006396 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276006397 N-terminal plug; other site 885276006398 ligand-binding site [chemical binding]; other site 885276006399 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 885276006400 ParB-like nuclease domain; Region: ParBc; cl02129 885276006401 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 885276006402 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885276006403 Active Sites [active] 885276006404 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 885276006405 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 885276006406 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 885276006407 putative trimer interface [polypeptide binding]; other site 885276006408 putative CoA binding site [chemical binding]; other site 885276006409 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276006410 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276006411 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276006412 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 885276006413 substrate binding site [chemical binding]; other site 885276006414 dimer interface [polypeptide binding]; other site 885276006415 ATP binding site [chemical binding]; other site 885276006416 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 885276006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 885276006418 Protein of unknown function, DUF606; Region: DUF606; pfam04657 885276006419 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 885276006420 active site 885276006421 substrate binding pocket [chemical binding]; other site 885276006422 homodimer interaction site [polypeptide binding]; other site 885276006423 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885276006424 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885276006425 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276006426 Haemolysin expression modulating protein; Region: HHA; cl11501 885276006427 Transposase; Region: DEDD_Tnp_IS110; pfam01548 885276006428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 885276006429 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 885276006430 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 885276006431 transposase/IS protein; Provisional; Region: PRK09183 885276006432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276006433 Walker A motif; other site 885276006434 ATP binding site [chemical binding]; other site 885276006435 Walker B motif; other site 885276006436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 885276006437 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 885276006438 DNA-binding interface [nucleotide binding]; DNA binding site 885276006439 Integrase core domain; Region: rve; pfam00665 885276006440 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885276006441 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276006442 Walker A/P-loop; other site 885276006443 ATP binding site [chemical binding]; other site 885276006444 Q-loop/lid; other site 885276006445 ABC transporter signature motif; other site 885276006446 Walker B; other site 885276006447 D-loop; other site 885276006448 H-loop/switch region; other site 885276006449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276006450 dimer interface [polypeptide binding]; other site 885276006451 putative PBP binding regions; other site 885276006452 ABC-ATPase subunit interface; other site 885276006453 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 885276006454 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885276006455 putative ligand binding residues [chemical binding]; other site 885276006456 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885276006457 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276006458 N-terminal plug; other site 885276006459 ligand-binding site [chemical binding]; other site 885276006460 hypothetical protein; Provisional; Region: PRK09866 885276006461 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276006462 G1 box; other site 885276006463 GTP/Mg2+ binding site [chemical binding]; other site 885276006464 G2 box; other site 885276006465 Switch I region; other site 885276006466 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276006467 G3 box; other site 885276006468 Switch II region; other site 885276006469 GTP/Mg2+ binding site [chemical binding]; other site 885276006470 G4 box; other site 885276006471 G5 box; other site 885276006472 YjcZ-like protein; Region: YjcZ; pfam13990 885276006473 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 885276006474 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 885276006475 nucleophile elbow; other site 885276006476 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 885276006477 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885276006478 Protein of unknown function (DUF987); Region: DUF987; pfam06174 885276006479 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 885276006480 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885276006481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 885276006482 Switch II region; other site 885276006483 G4 box; other site 885276006484 G5 box; other site 885276006485 hypothetical protein; Provisional; Region: PRK05423 885276006486 Predicted membrane protein [Function unknown]; Region: COG1289 885276006487 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885276006488 DNA gyrase inhibitor; Provisional; Region: PRK10016 885276006489 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 885276006490 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 885276006491 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 885276006492 exonuclease I; Provisional; Region: sbcB; PRK11779 885276006493 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 885276006494 active site 885276006495 catalytic site [active] 885276006496 substrate binding site [chemical binding]; other site 885276006497 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 885276006498 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 885276006499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276006500 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885276006501 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276006502 dimerization interface [polypeptide binding]; other site 885276006503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885276006504 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 885276006505 putative NAD(P) binding site [chemical binding]; other site 885276006506 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 885276006507 antitoxin YefM; Provisional; Region: PRK11409 885276006508 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 885276006509 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 885276006510 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 885276006511 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 885276006512 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 885276006513 NAD binding site [chemical binding]; other site 885276006514 dimerization interface [polypeptide binding]; other site 885276006515 product binding site; other site 885276006516 substrate binding site [chemical binding]; other site 885276006517 zinc binding site [ion binding]; other site 885276006518 catalytic residues [active] 885276006519 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 885276006520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276006521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276006522 homodimer interface [polypeptide binding]; other site 885276006523 catalytic residue [active] 885276006524 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 885276006525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276006526 active site 885276006527 motif I; other site 885276006528 motif II; other site 885276006529 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 885276006530 putative active site pocket [active] 885276006531 4-fold oligomerization interface [polypeptide binding]; other site 885276006532 metal binding residues [ion binding]; metal-binding site 885276006533 3-fold/trimer interface [polypeptide binding]; other site 885276006534 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 885276006535 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 885276006536 putative active site [active] 885276006537 oxyanion strand; other site 885276006538 catalytic triad [active] 885276006539 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 885276006540 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 885276006541 catalytic residues [active] 885276006542 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 885276006543 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 885276006544 substrate binding site [chemical binding]; other site 885276006545 glutamase interaction surface [polypeptide binding]; other site 885276006546 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 885276006547 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 885276006548 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 885276006549 metal binding site [ion binding]; metal-binding site 885276006550 chain length determinant protein WzzB; Provisional; Region: PRK15471 885276006551 Chain length determinant protein; Region: Wzz; pfam02706 885276006552 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 885276006553 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 885276006554 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 885276006555 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 885276006556 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885276006557 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 885276006558 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 885276006559 phosphomannomutase CpsG; Provisional; Region: PRK15414 885276006560 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 885276006561 active site 885276006562 substrate binding site [chemical binding]; other site 885276006563 metal binding site [ion binding]; metal-binding site 885276006564 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 885276006565 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 885276006566 Substrate binding site; other site 885276006567 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 885276006568 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 885276006569 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 885276006570 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 885276006571 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 885276006572 NAD binding site [chemical binding]; other site 885276006573 homodimer interface [polypeptide binding]; other site 885276006574 active site 885276006575 substrate binding site [chemical binding]; other site 885276006576 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 885276006577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 885276006578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 885276006579 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 885276006580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885276006581 active site 885276006582 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 885276006583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 885276006584 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 885276006585 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 885276006586 active site 885276006587 tetramer interface; other site 885276006588 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 885276006589 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 885276006590 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 885276006591 putative ADP-binding pocket [chemical binding]; other site 885276006592 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 885276006593 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 885276006594 colanic acid exporter; Provisional; Region: PRK10459 885276006595 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 885276006596 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 885276006597 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 885276006598 phosphomannomutase CpsG; Provisional; Region: PRK15414 885276006599 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 885276006600 active site 885276006601 substrate binding site [chemical binding]; other site 885276006602 metal binding site [ion binding]; metal-binding site 885276006603 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 885276006604 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 885276006605 Substrate binding site; other site 885276006606 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 885276006607 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 885276006608 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 885276006609 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 885276006610 active site 885276006611 GDP-Mannose binding site [chemical binding]; other site 885276006612 dimer interface [polypeptide binding]; other site 885276006613 modified nudix motif 885276006614 metal binding site [ion binding]; metal-binding site 885276006615 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 885276006616 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 885276006617 NADP binding site [chemical binding]; other site 885276006618 active site 885276006619 putative substrate binding site [chemical binding]; other site 885276006620 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 885276006621 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 885276006622 NADP-binding site; other site 885276006623 homotetramer interface [polypeptide binding]; other site 885276006624 substrate binding site [chemical binding]; other site 885276006625 homodimer interface [polypeptide binding]; other site 885276006626 active site 885276006627 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 885276006628 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 885276006629 putative trimer interface [polypeptide binding]; other site 885276006630 putative active site [active] 885276006631 putative substrate binding site [chemical binding]; other site 885276006632 putative CoA binding site [chemical binding]; other site 885276006633 putative glycosyl transferase; Provisional; Region: PRK10063 885276006634 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 885276006635 metal-binding site 885276006636 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 885276006637 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 885276006638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885276006639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885276006640 putative acyl transferase; Provisional; Region: PRK10191 885276006641 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 885276006642 trimer interface [polypeptide binding]; other site 885276006643 active site 885276006644 substrate binding site [chemical binding]; other site 885276006645 CoA binding site [chemical binding]; other site 885276006646 putative glycosyl transferase; Provisional; Region: PRK10018 885276006647 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 885276006648 active site 885276006649 tyrosine kinase; Provisional; Region: PRK11519 885276006650 Chain length determinant protein; Region: Wzz; pfam02706 885276006651 Chain length determinant protein; Region: Wzz; cl15801 885276006652 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 885276006653 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885276006654 Low molecular weight phosphatase family; Region: LMWPc; cd00115 885276006655 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 885276006656 active site 885276006657 polysaccharide export protein Wza; Provisional; Region: PRK15078 885276006658 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 885276006659 SLBB domain; Region: SLBB; pfam10531 885276006660 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885276006661 FOG: CBS domain [General function prediction only]; Region: COG0517 885276006662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885276006663 Transporter associated domain; Region: CorC_HlyC; smart01091 885276006664 putative assembly protein; Provisional; Region: PRK10833 885276006665 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 885276006666 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 885276006667 trimer interface [polypeptide binding]; other site 885276006668 active site 885276006669 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 885276006670 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 885276006671 ATP-binding site [chemical binding]; other site 885276006672 Sugar specificity; other site 885276006673 Pyrimidine base specificity; other site 885276006674 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 885276006675 putative diguanylate cyclase; Provisional; Region: PRK09776 885276006676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276006677 putative active site [active] 885276006678 heme pocket [chemical binding]; other site 885276006679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276006680 putative active site [active] 885276006681 heme pocket [chemical binding]; other site 885276006682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276006683 putative active site [active] 885276006684 heme pocket [chemical binding]; other site 885276006685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276006686 metal binding site [ion binding]; metal-binding site 885276006687 active site 885276006688 I-site; other site 885276006689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276006690 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 885276006691 AlkA N-terminal domain; Region: AlkA_N; smart01009 885276006692 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 885276006693 minor groove reading motif; other site 885276006694 helix-hairpin-helix signature motif; other site 885276006695 substrate binding pocket [chemical binding]; other site 885276006696 active site 885276006697 putative chaperone; Provisional; Region: PRK11678 885276006698 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 885276006699 nucleotide binding site [chemical binding]; other site 885276006700 putative NEF/HSP70 interaction site [polypeptide binding]; other site 885276006701 SBD interface [polypeptide binding]; other site 885276006702 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 885276006703 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 885276006704 substrate binding site [chemical binding]; other site 885276006705 activation loop (A-loop); other site 885276006706 Protein phosphatase 2C; Region: PP2C_2; pfam13672 885276006707 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 885276006708 metal ion-dependent adhesion site (MIDAS); other site 885276006709 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 885276006710 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276006711 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276006712 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 885276006713 Protein export membrane protein; Region: SecD_SecF; cl14618 885276006714 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 885276006715 putative transporter; Provisional; Region: PRK10504 885276006716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276006717 putative substrate translocation pore; other site 885276006718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 885276006719 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 885276006720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276006721 dimerization interface [polypeptide binding]; other site 885276006722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276006723 dimer interface [polypeptide binding]; other site 885276006724 phosphorylation site [posttranslational modification] 885276006725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276006726 ATP binding site [chemical binding]; other site 885276006727 Mg2+ binding site [ion binding]; other site 885276006728 G-X-G motif; other site 885276006729 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 885276006730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276006731 active site 885276006732 phosphorylation site [posttranslational modification] 885276006733 intermolecular recognition site; other site 885276006734 dimerization interface [polypeptide binding]; other site 885276006735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276006736 DNA binding site [nucleotide binding] 885276006737 Uncharacterized conserved protein [Function unknown]; Region: COG3422 885276006738 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 885276006739 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 885276006740 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 885276006741 PcfJ-like protein; Region: PcfJ; pfam14284 885276006742 putative protease; Provisional; Region: PRK15452 885276006743 Peptidase family U32; Region: Peptidase_U32; pfam01136 885276006744 lipid kinase; Reviewed; Region: PRK13054 885276006745 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 885276006746 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276006747 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276006748 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276006749 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 885276006750 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 885276006751 putative NAD(P) binding site [chemical binding]; other site 885276006752 catalytic Zn binding site [ion binding]; other site 885276006753 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 885276006754 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 885276006755 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 885276006756 active site 885276006757 P-loop; other site 885276006758 phosphorylation site [posttranslational modification] 885276006759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276006760 active site 885276006761 phosphorylation site [posttranslational modification] 885276006762 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 885276006763 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885276006764 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885276006765 intersubunit interface [polypeptide binding]; other site 885276006766 active site 885276006767 zinc binding site [ion binding]; other site 885276006768 Na+ binding site [ion binding]; other site 885276006769 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 885276006770 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 885276006771 putative active site; other site 885276006772 catalytic residue [active] 885276006773 nucleoside transporter; Region: 2A0110; TIGR00889 885276006774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276006775 putative substrate translocation pore; other site 885276006776 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 885276006777 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276006778 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 885276006779 substrate binding site [chemical binding]; other site 885276006780 ATP binding site [chemical binding]; other site 885276006781 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 885276006782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276006783 DNA-binding site [nucleotide binding]; DNA binding site 885276006784 UTRA domain; Region: UTRA; pfam07702 885276006785 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 885276006786 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 885276006787 active site 885276006788 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 885276006789 dimer interface [polypeptide binding]; other site 885276006790 substrate binding site [chemical binding]; other site 885276006791 ATP binding site [chemical binding]; other site 885276006792 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 885276006793 substrate binding site [chemical binding]; other site 885276006794 multimerization interface [polypeptide binding]; other site 885276006795 ATP binding site [chemical binding]; other site 885276006796 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 885276006797 putative metal binding site [ion binding]; other site 885276006798 putative homodimer interface [polypeptide binding]; other site 885276006799 putative homotetramer interface [polypeptide binding]; other site 885276006800 putative homodimer-homodimer interface [polypeptide binding]; other site 885276006801 putative allosteric switch controlling residues; other site 885276006802 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 885276006803 Predicted integral membrane protein [Function unknown]; Region: COG5455 885276006804 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 885276006805 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 885276006806 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 885276006807 PapC N-terminal domain; Region: PapC_N; pfam13954 885276006808 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276006809 PapC C-terminal domain; Region: PapC_C; pfam13953 885276006810 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 885276006811 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276006812 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276006813 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276006814 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 885276006815 antiporter inner membrane protein; Provisional; Region: PRK11670 885276006816 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 885276006817 Walker A motif; other site 885276006818 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 885276006819 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 885276006820 active site 885276006821 HIGH motif; other site 885276006822 KMSKS motif; other site 885276006823 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 885276006824 tRNA binding surface [nucleotide binding]; other site 885276006825 anticodon binding site; other site 885276006826 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 885276006827 dimer interface [polypeptide binding]; other site 885276006828 putative tRNA-binding site [nucleotide binding]; other site 885276006829 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 885276006830 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 885276006831 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 885276006832 MoxR-like ATPases [General function prediction only]; Region: COG0714 885276006833 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 885276006834 Walker A motif; other site 885276006835 ATP binding site [chemical binding]; other site 885276006836 Walker B motif; other site 885276006837 arginine finger; other site 885276006838 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 885276006839 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 885276006840 metal ion-dependent adhesion site (MIDAS); other site 885276006841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 885276006842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 885276006843 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 885276006844 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 885276006845 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 885276006846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276006847 active site 885276006848 phosphorylation site [posttranslational modification] 885276006849 intermolecular recognition site; other site 885276006850 dimerization interface [polypeptide binding]; other site 885276006851 LytTr DNA-binding domain; Region: LytTR; pfam04397 885276006852 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 885276006853 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 885276006854 GAF domain; Region: GAF; pfam01590 885276006855 Histidine kinase; Region: His_kinase; pfam06580 885276006856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276006857 ATP binding site [chemical binding]; other site 885276006858 Mg2+ binding site [ion binding]; other site 885276006859 G-X-G motif; other site 885276006860 transcriptional regulator MirA; Provisional; Region: PRK15043 885276006861 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 885276006862 DNA binding residues [nucleotide binding] 885276006863 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 885276006864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276006865 dimer interface [polypeptide binding]; other site 885276006866 conserved gate region; other site 885276006867 putative PBP binding loops; other site 885276006868 ABC-ATPase subunit interface; other site 885276006869 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 885276006870 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 885276006871 Walker A/P-loop; other site 885276006872 ATP binding site [chemical binding]; other site 885276006873 Q-loop/lid; other site 885276006874 ABC transporter signature motif; other site 885276006875 Walker B; other site 885276006876 D-loop; other site 885276006877 H-loop/switch region; other site 885276006878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 885276006879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276006880 dimer interface [polypeptide binding]; other site 885276006881 conserved gate region; other site 885276006882 ABC-ATPase subunit interface; other site 885276006883 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 885276006884 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 885276006885 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 885276006886 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 885276006887 D-lactate dehydrogenase; Provisional; Region: PRK11183 885276006888 FAD binding domain; Region: FAD_binding_4; pfam01565 885276006889 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 885276006890 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 885276006891 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 885276006892 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 885276006893 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885276006894 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 885276006895 classical (c) SDRs; Region: SDR_c; cd05233 885276006896 active site 885276006897 classical (c) SDRs; Region: SDR_c; cd05233 885276006898 NAD(P) binding site [chemical binding]; other site 885276006899 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 885276006900 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 885276006901 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 885276006902 FMN binding site [chemical binding]; other site 885276006903 active site 885276006904 catalytic residues [active] 885276006905 substrate binding site [chemical binding]; other site 885276006906 hypothetical protein; Provisional; Region: PRK01821 885276006907 hypothetical protein; Provisional; Region: PRK10711 885276006908 cytidine deaminase; Provisional; Region: PRK09027 885276006909 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 885276006910 active site 885276006911 catalytic motif [active] 885276006912 Zn binding site [ion binding]; other site 885276006913 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 885276006914 active site 885276006915 catalytic motif [active] 885276006916 Zn binding site [ion binding]; other site 885276006917 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885276006918 putative active site [active] 885276006919 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 885276006920 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 885276006921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885276006922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276006923 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 885276006924 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 885276006925 homodimer interface [polypeptide binding]; other site 885276006926 active site 885276006927 FMN binding site [chemical binding]; other site 885276006928 substrate binding site [chemical binding]; other site 885276006929 4Fe-4S binding domain; Region: Fer4; pfam00037 885276006930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276006931 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276006932 TM-ABC transporter signature motif; other site 885276006933 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276006934 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 885276006935 Walker A/P-loop; other site 885276006936 ATP binding site [chemical binding]; other site 885276006937 Q-loop/lid; other site 885276006938 ABC transporter signature motif; other site 885276006939 Walker B; other site 885276006940 D-loop; other site 885276006941 H-loop/switch region; other site 885276006942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276006943 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 885276006944 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 885276006945 ligand binding site [chemical binding]; other site 885276006946 calcium binding site [ion binding]; other site 885276006947 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 885276006948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276006949 DNA binding site [nucleotide binding] 885276006950 domain linker motif; other site 885276006951 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 885276006952 dimerization interface (closed form) [polypeptide binding]; other site 885276006953 ligand binding site [chemical binding]; other site 885276006954 Predicted membrane protein [Function unknown]; Region: COG2311 885276006955 hypothetical protein; Provisional; Region: PRK10835 885276006956 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 885276006957 homodecamer interface [polypeptide binding]; other site 885276006958 GTP cyclohydrolase I; Provisional; Region: PLN03044 885276006959 active site 885276006960 putative catalytic site residues [active] 885276006961 zinc binding site [ion binding]; other site 885276006962 GTP-CH-I/GFRP interaction surface; other site 885276006963 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 885276006964 S-formylglutathione hydrolase; Region: PLN02442 885276006965 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 885276006966 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276006967 N-terminal plug; other site 885276006968 ligand-binding site [chemical binding]; other site 885276006969 lysine transporter; Provisional; Region: PRK10836 885276006970 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 885276006971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276006972 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 885276006973 putative dimerization interface [polypeptide binding]; other site 885276006974 conserved hypothetical integral membrane protein; Region: TIGR00698 885276006975 endonuclease IV; Provisional; Region: PRK01060 885276006976 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 885276006977 AP (apurinic/apyrimidinic) site pocket; other site 885276006978 DNA interaction; other site 885276006979 Metal-binding active site; metal-binding site 885276006980 putative kinase; Provisional; Region: PRK09954 885276006981 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276006982 putative DNA binding site [nucleotide binding]; other site 885276006983 putative Zn2+ binding site [ion binding]; other site 885276006984 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 885276006985 substrate binding site [chemical binding]; other site 885276006986 ATP binding site [chemical binding]; other site 885276006987 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 885276006988 active site 885276006989 tetramer interface [polypeptide binding]; other site 885276006990 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 885276006991 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 885276006992 ligand binding site [chemical binding]; other site 885276006993 flexible hinge region; other site 885276006994 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 885276006995 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 885276006996 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 885276006997 Nucleoside recognition; Region: Gate; pfam07670 885276006998 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 885276006999 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 885276007000 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 885276007001 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276007002 substrate binding site [chemical binding]; other site 885276007003 ATP binding site [chemical binding]; other site 885276007004 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 885276007005 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 885276007006 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885276007007 active site 885276007008 P-loop; other site 885276007009 phosphorylation site [posttranslational modification] 885276007010 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 885276007011 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 885276007012 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 885276007013 putative substrate binding site [chemical binding]; other site 885276007014 putative ATP binding site [chemical binding]; other site 885276007015 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 885276007016 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276007017 active site 885276007018 phosphorylation site [posttranslational modification] 885276007019 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276007020 dimerization domain swap beta strand [polypeptide binding]; other site 885276007021 regulatory protein interface [polypeptide binding]; other site 885276007022 active site 885276007023 regulatory phosphorylation site [posttranslational modification]; other site 885276007024 sugar efflux transporter B; Provisional; Region: PRK15011 885276007025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007026 putative substrate translocation pore; other site 885276007027 elongation factor P; Provisional; Region: PRK04542 885276007028 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 885276007029 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 885276007030 RNA binding site [nucleotide binding]; other site 885276007031 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 885276007032 RNA binding site [nucleotide binding]; other site 885276007033 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 885276007034 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885276007035 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885276007036 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 885276007037 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 885276007038 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 885276007039 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 885276007040 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 885276007041 active site 885276007042 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 885276007043 NlpC/P60 family; Region: NLPC_P60; pfam00877 885276007044 phage resistance protein; Provisional; Region: PRK10551 885276007045 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885276007046 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276007047 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 885276007048 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 885276007049 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 885276007050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276007051 dimer interface [polypeptide binding]; other site 885276007052 conserved gate region; other site 885276007053 putative PBP binding loops; other site 885276007054 ABC-ATPase subunit interface; other site 885276007055 microcin C ABC transporter permease; Provisional; Region: PRK15021 885276007056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276007057 dimer interface [polypeptide binding]; other site 885276007058 conserved gate region; other site 885276007059 ABC-ATPase subunit interface; other site 885276007060 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 885276007061 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276007062 Walker A/P-loop; other site 885276007063 ATP binding site [chemical binding]; other site 885276007064 Q-loop/lid; other site 885276007065 ABC transporter signature motif; other site 885276007066 Walker B; other site 885276007067 D-loop; other site 885276007068 H-loop/switch region; other site 885276007069 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885276007070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276007071 Walker A/P-loop; other site 885276007072 ATP binding site [chemical binding]; other site 885276007073 Q-loop/lid; other site 885276007074 ABC transporter signature motif; other site 885276007075 Walker B; other site 885276007076 D-loop; other site 885276007077 H-loop/switch region; other site 885276007078 hypothetical protein; Provisional; Region: PRK11835 885276007079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007080 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 885276007081 putative substrate translocation pore; other site 885276007082 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 885276007083 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276007084 RNA binding surface [nucleotide binding]; other site 885276007085 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 885276007086 active site 885276007087 uracil binding [chemical binding]; other site 885276007088 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 885276007089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276007090 ATP binding site [chemical binding]; other site 885276007091 putative Mg++ binding site [ion binding]; other site 885276007092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276007093 nucleotide binding region [chemical binding]; other site 885276007094 ATP-binding site [chemical binding]; other site 885276007095 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 885276007096 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 885276007097 5S rRNA interface [nucleotide binding]; other site 885276007098 CTC domain interface [polypeptide binding]; other site 885276007099 L16 interface [polypeptide binding]; other site 885276007100 Nucleoid-associated protein [General function prediction only]; Region: COG3081 885276007101 nucleoid-associated protein NdpA; Validated; Region: PRK00378 885276007102 hypothetical protein; Provisional; Region: PRK13689 885276007103 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 885276007104 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 885276007105 Sulfatase; Region: Sulfatase; pfam00884 885276007106 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276007107 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 885276007108 transcriptional regulator NarP; Provisional; Region: PRK10403 885276007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007110 active site 885276007111 phosphorylation site [posttranslational modification] 885276007112 intermolecular recognition site; other site 885276007113 dimerization interface [polypeptide binding]; other site 885276007114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276007115 DNA binding residues [nucleotide binding] 885276007116 dimerization interface [polypeptide binding]; other site 885276007117 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 885276007118 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 885276007119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 885276007120 binding surface 885276007121 TPR motif; other site 885276007122 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 885276007123 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 885276007124 catalytic residues [active] 885276007125 central insert; other site 885276007126 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 885276007127 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 885276007128 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 885276007129 heme exporter protein CcmC; Region: ccmC; TIGR01191 885276007130 heme exporter protein CcmB; Region: ccmB; TIGR01190 885276007131 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 885276007132 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 885276007133 Walker A/P-loop; other site 885276007134 ATP binding site [chemical binding]; other site 885276007135 Q-loop/lid; other site 885276007136 ABC transporter signature motif; other site 885276007137 Walker B; other site 885276007138 D-loop; other site 885276007139 H-loop/switch region; other site 885276007140 cytochrome c-type protein NapC; Provisional; Region: PRK10617 885276007141 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 885276007142 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 885276007143 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 885276007144 4Fe-4S binding domain; Region: Fer4_5; pfam12801 885276007145 4Fe-4S binding domain; Region: Fer4; cl02805 885276007146 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 885276007147 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 885276007148 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 885276007149 [4Fe-4S] binding site [ion binding]; other site 885276007150 molybdopterin cofactor binding site; other site 885276007151 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 885276007152 molybdopterin cofactor binding site; other site 885276007153 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 885276007154 ferredoxin-type protein; Provisional; Region: PRK10194 885276007155 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 885276007156 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 885276007157 secondary substrate binding site; other site 885276007158 primary substrate binding site; other site 885276007159 inhibition loop; other site 885276007160 dimerization interface [polypeptide binding]; other site 885276007161 malate:quinone oxidoreductase; Validated; Region: PRK05257 885276007162 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 885276007163 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 885276007164 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 885276007165 Walker A/P-loop; other site 885276007166 ATP binding site [chemical binding]; other site 885276007167 Q-loop/lid; other site 885276007168 ABC transporter signature motif; other site 885276007169 Walker B; other site 885276007170 D-loop; other site 885276007171 H-loop/switch region; other site 885276007172 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 885276007173 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 885276007174 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 885276007175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276007176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276007177 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 885276007178 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 885276007179 DNA binding site [nucleotide binding] 885276007180 active site 885276007181 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 885276007182 ApbE family; Region: ApbE; pfam02424 885276007183 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 885276007184 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 885276007185 trimer interface [polypeptide binding]; other site 885276007186 eyelet of channel; other site 885276007187 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 885276007188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276007189 ATP binding site [chemical binding]; other site 885276007190 G-X-G motif; other site 885276007191 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885276007192 putative binding surface; other site 885276007193 active site 885276007194 transcriptional regulator RcsB; Provisional; Region: PRK10840 885276007195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007196 active site 885276007197 phosphorylation site [posttranslational modification] 885276007198 intermolecular recognition site; other site 885276007199 dimerization interface [polypeptide binding]; other site 885276007200 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276007201 DNA binding residues [nucleotide binding] 885276007202 dimerization interface [polypeptide binding]; other site 885276007203 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 885276007204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276007205 dimer interface [polypeptide binding]; other site 885276007206 phosphorylation site [posttranslational modification] 885276007207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276007208 ATP binding site [chemical binding]; other site 885276007209 Mg2+ binding site [ion binding]; other site 885276007210 G-X-G motif; other site 885276007211 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 885276007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007213 active site 885276007214 phosphorylation site [posttranslational modification] 885276007215 intermolecular recognition site; other site 885276007216 dimerization interface [polypeptide binding]; other site 885276007217 sensory histidine kinase AtoS; Provisional; Region: PRK11360 885276007218 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276007219 putative active site [active] 885276007220 heme pocket [chemical binding]; other site 885276007221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276007222 dimer interface [polypeptide binding]; other site 885276007223 phosphorylation site [posttranslational modification] 885276007224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276007225 ATP binding site [chemical binding]; other site 885276007226 Mg2+ binding site [ion binding]; other site 885276007227 G-X-G motif; other site 885276007228 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 885276007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007230 active site 885276007231 phosphorylation site [posttranslational modification] 885276007232 intermolecular recognition site; other site 885276007233 dimerization interface [polypeptide binding]; other site 885276007234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276007235 Walker A motif; other site 885276007236 ATP binding site [chemical binding]; other site 885276007237 Walker B motif; other site 885276007238 arginine finger; other site 885276007239 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276007240 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 885276007241 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 885276007242 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 885276007243 putative acyltransferase; Provisional; Region: PRK05790 885276007244 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885276007245 dimer interface [polypeptide binding]; other site 885276007246 active site 885276007247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 885276007248 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 885276007249 Predicted secreted protein [Function unknown]; Region: COG5445 885276007250 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 885276007251 Predicted secreted protein [Function unknown]; Region: COG5445 885276007252 Stage II sporulation protein; Region: SpoIID; pfam08486 885276007253 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 885276007254 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 885276007255 MG2 domain; Region: A2M_N; pfam01835 885276007256 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 885276007257 Alpha-2-macroglobulin family; Region: A2M; pfam00207 885276007258 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 885276007259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 885276007260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 885276007261 DNA gyrase subunit A; Validated; Region: PRK05560 885276007262 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 885276007263 CAP-like domain; other site 885276007264 active site 885276007265 primary dimer interface [polypeptide binding]; other site 885276007266 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276007267 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276007268 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276007269 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276007270 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276007271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276007272 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 885276007273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276007274 S-adenosylmethionine binding site [chemical binding]; other site 885276007275 adhesin; Provisional; Region: PRK09752 885276007276 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885276007277 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276007278 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 885276007279 ATP cone domain; Region: ATP-cone; pfam03477 885276007280 Class I ribonucleotide reductase; Region: RNR_I; cd01679 885276007281 active site 885276007282 dimer interface [polypeptide binding]; other site 885276007283 catalytic residues [active] 885276007284 effector binding site; other site 885276007285 R2 peptide binding site; other site 885276007286 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 885276007287 dimer interface [polypeptide binding]; other site 885276007288 putative radical transfer pathway; other site 885276007289 diiron center [ion binding]; other site 885276007290 tyrosyl radical; other site 885276007291 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 885276007292 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885276007293 catalytic loop [active] 885276007294 iron binding site [ion binding]; other site 885276007295 hypothetical protein; Provisional; Region: PRK09902 885276007296 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 885276007297 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 885276007298 active site 885276007299 catalytic site [active] 885276007300 metal binding site [ion binding]; metal-binding site 885276007301 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 885276007302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007303 putative substrate translocation pore; other site 885276007304 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 885276007305 hydroxyglutarate oxidase; Provisional; Region: PRK11728 885276007306 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 885276007307 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 885276007308 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 885276007309 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 885276007310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276007311 Cysteine-rich domain; Region: CCG; pfam02754 885276007312 Cysteine-rich domain; Region: CCG; pfam02754 885276007313 hypothetical protein; Provisional; Region: PRK09956 885276007314 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885276007315 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 885276007316 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 885276007317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007318 putative substrate translocation pore; other site 885276007319 L-rhamnonate dehydratase; Provisional; Region: PRK15440 885276007320 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 885276007321 putative active site pocket [active] 885276007322 putative metal binding site [ion binding]; other site 885276007323 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885276007324 Transcriptional regulator [Transcription]; Region: IclR; COG1414 885276007325 Bacterial transcriptional regulator; Region: IclR; pfam01614 885276007326 hypothetical protein; Provisional; Region: PRK03673 885276007327 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 885276007328 putative MPT binding site; other site 885276007329 Competence-damaged protein; Region: CinA; cl00666 885276007330 YfaZ precursor; Region: YfaZ; pfam07437 885276007331 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 885276007332 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 885276007333 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 885276007334 catalytic core [active] 885276007335 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 885276007336 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 885276007337 inhibitor-cofactor binding pocket; inhibition site 885276007338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276007339 catalytic residue [active] 885276007340 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 885276007341 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 885276007342 Ligand binding site; other site 885276007343 Putative Catalytic site; other site 885276007344 DXD motif; other site 885276007345 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 885276007346 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 885276007347 substrate binding site [chemical binding]; other site 885276007348 cosubstrate binding site; other site 885276007349 catalytic site [active] 885276007350 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 885276007351 active site 885276007352 hexamer interface [polypeptide binding]; other site 885276007353 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 885276007354 NAD binding site [chemical binding]; other site 885276007355 substrate binding site [chemical binding]; other site 885276007356 active site 885276007357 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 885276007358 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 885276007359 putative active site [active] 885276007360 putative catalytic site [active] 885276007361 putative Zn binding site [ion binding]; other site 885276007362 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 885276007363 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 885276007364 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 885276007365 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 885276007366 signal transduction protein PmrD; Provisional; Region: PRK15450 885276007367 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 885276007368 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 885276007369 acyl-activating enzyme (AAE) consensus motif; other site 885276007370 putative AMP binding site [chemical binding]; other site 885276007371 putative active site [active] 885276007372 putative CoA binding site [chemical binding]; other site 885276007373 O-succinylbenzoate synthase; Provisional; Region: PRK05105 885276007374 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 885276007375 active site 885276007376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885276007377 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 885276007378 substrate binding site [chemical binding]; other site 885276007379 oxyanion hole (OAH) forming residues; other site 885276007380 trimer interface [polypeptide binding]; other site 885276007381 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 885276007382 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 885276007383 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 885276007384 dimer interface [polypeptide binding]; other site 885276007385 tetramer interface [polypeptide binding]; other site 885276007386 PYR/PP interface [polypeptide binding]; other site 885276007387 TPP binding site [chemical binding]; other site 885276007388 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 885276007389 TPP-binding site; other site 885276007390 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 885276007391 isochorismate synthases; Region: isochor_syn; TIGR00543 885276007392 hypothetical protein; Provisional; Region: PRK10404 885276007393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276007394 Coenzyme A binding pocket [chemical binding]; other site 885276007395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 885276007396 von Willebrand factor; Region: vWF_A; pfam12450 885276007397 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 885276007398 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 885276007399 metal ion-dependent adhesion site (MIDAS); other site 885276007400 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 885276007401 M28 Zn-Peptidases; Region: M28_like_1; cd05640 885276007402 Peptidase family M28; Region: Peptidase_M28; pfam04389 885276007403 metal binding site [ion binding]; metal-binding site 885276007404 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 885276007405 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 885276007406 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885276007407 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 885276007408 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885276007409 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 885276007410 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 885276007411 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885276007412 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 885276007413 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 885276007414 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 885276007415 4Fe-4S binding domain; Region: Fer4; pfam00037 885276007416 4Fe-4S binding domain; Region: Fer4; pfam00037 885276007417 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 885276007418 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 885276007419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885276007420 catalytic loop [active] 885276007421 iron binding site [ion binding]; other site 885276007422 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 885276007423 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 885276007424 [4Fe-4S] binding site [ion binding]; other site 885276007425 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 885276007426 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 885276007427 SLBB domain; Region: SLBB; pfam10531 885276007428 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 885276007429 NADH dehydrogenase subunit E; Validated; Region: PRK07539 885276007430 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 885276007431 putative dimer interface [polypeptide binding]; other site 885276007432 [2Fe-2S] cluster binding site [ion binding]; other site 885276007433 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 885276007434 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 885276007435 NADH dehydrogenase subunit D; Validated; Region: PRK06075 885276007436 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 885276007437 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 885276007438 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 885276007439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276007440 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 885276007441 putative dimerization interface [polypeptide binding]; other site 885276007442 aminotransferase AlaT; Validated; Region: PRK09265 885276007443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276007444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276007445 homodimer interface [polypeptide binding]; other site 885276007446 catalytic residue [active] 885276007447 5'-nucleotidase; Provisional; Region: PRK03826 885276007448 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 885276007449 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276007450 TrkA-C domain; Region: TrkA_C; pfam02080 885276007451 TrkA-C domain; Region: TrkA_C; pfam02080 885276007452 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 885276007453 putative phosphatase; Provisional; Region: PRK11587 885276007454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276007455 motif II; other site 885276007456 hypothetical protein; Validated; Region: PRK05445 885276007457 hypothetical protein; Provisional; Region: PRK01816 885276007458 propionate/acetate kinase; Provisional; Region: PRK12379 885276007459 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 885276007460 phosphate acetyltransferase; Reviewed; Region: PRK05632 885276007461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 885276007462 DRTGG domain; Region: DRTGG; pfam07085 885276007463 phosphate acetyltransferase; Region: pta; TIGR00651 885276007464 hypothetical protein; Provisional; Region: PRK11588 885276007465 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 885276007466 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 885276007467 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 885276007468 nudix motif; other site 885276007469 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 885276007470 active site 885276007471 metal binding site [ion binding]; metal-binding site 885276007472 homotetramer interface [polypeptide binding]; other site 885276007473 glutathione S-transferase; Provisional; Region: PRK15113 885276007474 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 885276007475 C-terminal domain interface [polypeptide binding]; other site 885276007476 GSH binding site (G-site) [chemical binding]; other site 885276007477 dimer interface [polypeptide binding]; other site 885276007478 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 885276007479 N-terminal domain interface [polypeptide binding]; other site 885276007480 putative dimer interface [polypeptide binding]; other site 885276007481 putative substrate binding pocket (H-site) [chemical binding]; other site 885276007482 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 885276007483 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 885276007484 C-terminal domain interface [polypeptide binding]; other site 885276007485 GSH binding site (G-site) [chemical binding]; other site 885276007486 dimer interface [polypeptide binding]; other site 885276007487 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 885276007488 N-terminal domain interface [polypeptide binding]; other site 885276007489 putative dimer interface [polypeptide binding]; other site 885276007490 active site 885276007491 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 885276007492 homooctamer interface [polypeptide binding]; other site 885276007493 active site 885276007494 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 885276007495 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 885276007496 putative NAD(P) binding site [chemical binding]; other site 885276007497 putative active site [active] 885276007498 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 885276007499 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885276007500 Walker A/P-loop; other site 885276007501 ATP binding site [chemical binding]; other site 885276007502 Q-loop/lid; other site 885276007503 ABC transporter signature motif; other site 885276007504 Walker B; other site 885276007505 D-loop; other site 885276007506 H-loop/switch region; other site 885276007507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276007508 dimer interface [polypeptide binding]; other site 885276007509 conserved gate region; other site 885276007510 putative PBP binding loops; other site 885276007511 ABC-ATPase subunit interface; other site 885276007512 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276007513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276007514 dimer interface [polypeptide binding]; other site 885276007515 conserved gate region; other site 885276007516 putative PBP binding loops; other site 885276007517 ABC-ATPase subunit interface; other site 885276007518 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 885276007519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276007520 substrate binding pocket [chemical binding]; other site 885276007521 membrane-bound complex binding site; other site 885276007522 hinge residues; other site 885276007523 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 885276007524 Flavoprotein; Region: Flavoprotein; pfam02441 885276007525 amidophosphoribosyltransferase; Provisional; Region: PRK09246 885276007526 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 885276007527 active site 885276007528 tetramer interface [polypeptide binding]; other site 885276007529 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276007530 active site 885276007531 colicin V production protein; Provisional; Region: PRK10845 885276007532 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 885276007533 cell division protein DedD; Provisional; Region: PRK11633 885276007534 Sporulation related domain; Region: SPOR; pfam05036 885276007535 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 885276007536 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885276007537 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885276007538 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 885276007539 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 885276007540 hypothetical protein; Provisional; Region: PRK10847 885276007541 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885276007542 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 885276007543 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 885276007544 dimerization interface 3.5A [polypeptide binding]; other site 885276007545 active site 885276007546 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 885276007547 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 885276007548 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 885276007549 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 885276007550 ligand binding site [chemical binding]; other site 885276007551 NAD binding site [chemical binding]; other site 885276007552 catalytic site [active] 885276007553 homodimer interface [polypeptide binding]; other site 885276007554 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 885276007555 putative transporter; Provisional; Region: PRK12382 885276007556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007557 putative substrate translocation pore; other site 885276007558 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 885276007559 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 885276007560 dimer interface [polypeptide binding]; other site 885276007561 active site 885276007562 Uncharacterized conserved protein [Function unknown]; Region: COG4121 885276007563 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 885276007564 YfcL protein; Region: YfcL; pfam08891 885276007565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 885276007566 hypothetical protein; Provisional; Region: PRK10621 885276007567 Predicted permeases [General function prediction only]; Region: COG0730 885276007568 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 885276007569 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 885276007570 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 885276007571 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 885276007572 Tetramer interface [polypeptide binding]; other site 885276007573 active site 885276007574 FMN-binding site [chemical binding]; other site 885276007575 HemK family putative methylases; Region: hemK_fam; TIGR00536 885276007576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276007577 S-adenosylmethionine binding site [chemical binding]; other site 885276007578 hypothetical protein; Provisional; Region: PRK04946 885276007579 Smr domain; Region: Smr; pfam01713 885276007580 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 885276007581 Fimbrial protein; Region: Fimbrial; cl01416 885276007582 Fimbrial protein; Region: Fimbrial; cl01416 885276007583 Fimbrial protein; Region: Fimbrial; cl01416 885276007584 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276007585 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276007586 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 885276007587 PapC N-terminal domain; Region: PapC_N; pfam13954 885276007588 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276007589 PapC C-terminal domain; Region: PapC_C; pfam13953 885276007590 Fimbrial protein; Region: Fimbrial; cl01416 885276007591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885276007592 catalytic core [active] 885276007593 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 885276007594 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885276007595 substrate binding site [chemical binding]; other site 885276007596 oxyanion hole (OAH) forming residues; other site 885276007597 trimer interface [polypeptide binding]; other site 885276007598 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 885276007599 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885276007600 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 885276007601 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885276007602 dimer interface [polypeptide binding]; other site 885276007603 active site 885276007604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 885276007605 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 885276007606 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 885276007607 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 885276007608 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 885276007609 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885276007610 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 885276007611 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885276007612 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276007613 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276007614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276007615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276007616 DNA binding residues [nucleotide binding] 885276007617 dimerization interface [polypeptide binding]; other site 885276007618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276007619 active site 885276007620 DNA binding site [nucleotide binding] 885276007621 Int/Topo IB signature motif; other site 885276007622 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276007623 active site 885276007624 DNA binding site [nucleotide binding] 885276007625 Int/Topo IB signature motif; other site 885276007626 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 885276007627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276007628 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 885276007629 dimerization interface [polypeptide binding]; other site 885276007630 substrate binding pocket [chemical binding]; other site 885276007631 permease DsdX; Provisional; Region: PRK09921 885276007632 gluconate transporter; Region: gntP; TIGR00791 885276007633 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 885276007634 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 885276007635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276007636 catalytic residue [active] 885276007637 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 885276007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007639 putative substrate translocation pore; other site 885276007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007641 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 885276007642 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276007643 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276007644 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 885276007645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007646 active site 885276007647 phosphorylation site [posttranslational modification] 885276007648 intermolecular recognition site; other site 885276007649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276007650 DNA binding residues [nucleotide binding] 885276007651 dimerization interface [polypeptide binding]; other site 885276007652 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 885276007653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276007654 substrate binding pocket [chemical binding]; other site 885276007655 membrane-bound complex binding site; other site 885276007656 hinge residues; other site 885276007657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276007658 substrate binding pocket [chemical binding]; other site 885276007659 membrane-bound complex binding site; other site 885276007660 hinge residues; other site 885276007661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276007662 dimer interface [polypeptide binding]; other site 885276007663 phosphorylation site [posttranslational modification] 885276007664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276007665 ATP binding site [chemical binding]; other site 885276007666 Mg2+ binding site [ion binding]; other site 885276007667 G-X-G motif; other site 885276007668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007669 active site 885276007670 phosphorylation site [posttranslational modification] 885276007671 intermolecular recognition site; other site 885276007672 dimerization interface [polypeptide binding]; other site 885276007673 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885276007674 putative binding surface; other site 885276007675 active site 885276007676 putative CoA-transferase; Provisional; Region: PRK11430 885276007677 CoA-transferase family III; Region: CoA_transf_3; pfam02515 885276007678 putative transporter YfdV; Provisional; Region: PRK09903 885276007679 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 885276007680 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885276007681 PYR/PP interface [polypeptide binding]; other site 885276007682 dimer interface [polypeptide binding]; other site 885276007683 TPP binding site [chemical binding]; other site 885276007684 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885276007685 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 885276007686 TPP-binding site; other site 885276007687 dimer interface [polypeptide binding]; other site 885276007688 formyl-coenzyme A transferase; Provisional; Region: PRK05398 885276007689 CoA-transferase family III; Region: CoA_transf_3; pfam02515 885276007690 hypothetical protein; Provisional; Region: PRK10316 885276007691 YfdX protein; Region: YfdX; pfam10938 885276007692 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 885276007693 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 885276007694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 885276007695 putative acyl-acceptor binding pocket; other site 885276007696 aminotransferase; Validated; Region: PRK08175 885276007697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276007698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276007699 homodimer interface [polypeptide binding]; other site 885276007700 catalytic residue [active] 885276007701 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 885276007702 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 885276007703 GAF domain; Region: GAF; cl17456 885276007704 Histidine kinase; Region: His_kinase; pfam06580 885276007705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276007706 ATP binding site [chemical binding]; other site 885276007707 Mg2+ binding site [ion binding]; other site 885276007708 G-X-G motif; other site 885276007709 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 885276007710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276007711 active site 885276007712 phosphorylation site [posttranslational modification] 885276007713 intermolecular recognition site; other site 885276007714 dimerization interface [polypeptide binding]; other site 885276007715 LytTr DNA-binding domain; Region: LytTR; pfam04397 885276007716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276007717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276007718 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276007719 dimerization domain swap beta strand [polypeptide binding]; other site 885276007720 regulatory protein interface [polypeptide binding]; other site 885276007721 active site 885276007722 regulatory phosphorylation site [posttranslational modification]; other site 885276007723 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885276007724 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 885276007725 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885276007726 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885276007727 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276007728 active site 885276007729 phosphorylation site [posttranslational modification] 885276007730 exoaminopeptidase; Provisional; Region: PRK09961 885276007731 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 885276007732 oligomer interface [polypeptide binding]; other site 885276007733 active site 885276007734 metal binding site [ion binding]; metal-binding site 885276007735 aminopeptidase; Provisional; Region: PRK09795 885276007736 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 885276007737 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 885276007738 active site 885276007739 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 885276007740 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885276007741 active site 885276007742 P-loop; other site 885276007743 phosphorylation site [posttranslational modification] 885276007744 glucokinase, proteobacterial type; Region: glk; TIGR00749 885276007745 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276007746 nucleotide binding site [chemical binding]; other site 885276007747 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 885276007748 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 885276007749 Cl- selectivity filter; other site 885276007750 Cl- binding residues [ion binding]; other site 885276007751 pore gating glutamate residue; other site 885276007752 dimer interface [polypeptide binding]; other site 885276007753 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 885276007754 manganese transport protein MntH; Reviewed; Region: PRK00701 885276007755 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 885276007756 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 885276007757 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 885276007758 Nucleoside recognition; Region: Gate; pfam07670 885276007759 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 885276007760 MASE1; Region: MASE1; pfam05231 885276007761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276007762 diguanylate cyclase; Region: GGDEF; smart00267 885276007763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276007764 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 885276007765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276007766 salt bridge; other site 885276007767 non-specific DNA binding site [nucleotide binding]; other site 885276007768 sequence-specific DNA binding site [nucleotide binding]; other site 885276007769 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 885276007770 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 885276007771 active site 885276007772 HIGH motif; other site 885276007773 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 885276007774 active site 885276007775 KMSKS motif; other site 885276007776 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 885276007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276007778 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 885276007779 putative dimerization interface [polypeptide binding]; other site 885276007780 putative substrate binding pocket [chemical binding]; other site 885276007781 XapX domain; Region: XapX; TIGR03510 885276007782 nucleoside transporter; Region: 2A0110; TIGR00889 885276007783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276007784 putative substrate translocation pore; other site 885276007785 purine nucleoside phosphorylase; Provisional; Region: PRK08202 885276007786 hypothetical protein; Provisional; Region: PRK11528 885276007787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276007788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276007789 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 885276007790 putative dimerization interface [polypeptide binding]; other site 885276007791 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 885276007792 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 885276007793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 885276007794 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 885276007795 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 885276007796 nucleotide binding pocket [chemical binding]; other site 885276007797 K-X-D-G motif; other site 885276007798 catalytic site [active] 885276007799 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 885276007800 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 885276007801 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 885276007802 Dimer interface [polypeptide binding]; other site 885276007803 BRCT sequence motif; other site 885276007804 cell division protein ZipA; Provisional; Region: PRK03427 885276007805 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 885276007806 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 885276007807 FtsZ protein binding site [polypeptide binding]; other site 885276007808 putative sulfate transport protein CysZ; Validated; Region: PRK04949 885276007809 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 885276007810 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 885276007811 dimer interface [polypeptide binding]; other site 885276007812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276007813 catalytic residue [active] 885276007814 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276007815 dimerization domain swap beta strand [polypeptide binding]; other site 885276007816 regulatory protein interface [polypeptide binding]; other site 885276007817 active site 885276007818 regulatory phosphorylation site [posttranslational modification]; other site 885276007819 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 885276007820 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885276007821 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885276007822 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885276007823 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 885276007824 HPr interaction site; other site 885276007825 glycerol kinase (GK) interaction site [polypeptide binding]; other site 885276007826 active site 885276007827 phosphorylation site [posttranslational modification] 885276007828 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 885276007829 dimer interface [polypeptide binding]; other site 885276007830 pyridoxamine kinase; Validated; Region: PRK05756 885276007831 pyridoxal binding site [chemical binding]; other site 885276007832 ATP binding site [chemical binding]; other site 885276007833 hypothetical protein; Provisional; Region: PRK10318 885276007834 cysteine synthase B; Region: cysM; TIGR01138 885276007835 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 885276007836 dimer interface [polypeptide binding]; other site 885276007837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276007838 catalytic residue [active] 885276007839 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 885276007840 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 885276007841 Walker A/P-loop; other site 885276007842 ATP binding site [chemical binding]; other site 885276007843 Q-loop/lid; other site 885276007844 ABC transporter signature motif; other site 885276007845 Walker B; other site 885276007846 D-loop; other site 885276007847 H-loop/switch region; other site 885276007848 TOBE-like domain; Region: TOBE_3; pfam12857 885276007849 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 885276007850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276007851 dimer interface [polypeptide binding]; other site 885276007852 conserved gate region; other site 885276007853 putative PBP binding loops; other site 885276007854 ABC-ATPase subunit interface; other site 885276007855 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 885276007856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276007857 dimer interface [polypeptide binding]; other site 885276007858 conserved gate region; other site 885276007859 putative PBP binding loops; other site 885276007860 ABC-ATPase subunit interface; other site 885276007861 thiosulfate transporter subunit; Provisional; Region: PRK10852 885276007862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 885276007863 short chain dehydrogenase; Provisional; Region: PRK08226 885276007864 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 885276007865 NAD binding site [chemical binding]; other site 885276007866 homotetramer interface [polypeptide binding]; other site 885276007867 homodimer interface [polypeptide binding]; other site 885276007868 active site 885276007869 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 885276007870 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 885276007871 putative active site [active] 885276007872 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 885276007873 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276007874 active site turn [active] 885276007875 phosphorylation site [posttranslational modification] 885276007876 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276007877 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 885276007878 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 885276007879 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 885276007880 putative acetyltransferase; Provisional; Region: PRK03624 885276007881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276007882 Coenzyme A binding pocket [chemical binding]; other site 885276007883 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 885276007884 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 885276007885 active site 885276007886 metal binding site [ion binding]; metal-binding site 885276007887 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 885276007888 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 885276007889 transcriptional regulator EutR; Provisional; Region: PRK10130 885276007890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276007891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276007892 carboxysome structural protein EutK; Provisional; Region: PRK15466 885276007893 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 885276007894 Hexamer interface [polypeptide binding]; other site 885276007895 Hexagonal pore residue; other site 885276007896 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 885276007897 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 885276007898 putative hexamer interface [polypeptide binding]; other site 885276007899 putative hexagonal pore; other site 885276007900 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 885276007901 putative hexamer interface [polypeptide binding]; other site 885276007902 putative hexagonal pore; other site 885276007903 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 885276007904 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 885276007905 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 885276007906 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 885276007907 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 885276007908 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 885276007909 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 885276007910 active site 885276007911 metal binding site [ion binding]; metal-binding site 885276007912 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 885276007913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276007914 nucleotide binding site [chemical binding]; other site 885276007915 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 885276007916 putative catalytic cysteine [active] 885276007917 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 885276007918 Hexamer/Pentamer interface [polypeptide binding]; other site 885276007919 central pore; other site 885276007920 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 885276007921 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 885276007922 Hexamer interface [polypeptide binding]; other site 885276007923 Hexagonal pore residue; other site 885276007924 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 885276007925 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 885276007926 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 885276007927 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 885276007928 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 885276007929 G1 box; other site 885276007930 GTP/Mg2+ binding site [chemical binding]; other site 885276007931 G2 box; other site 885276007932 Switch I region; other site 885276007933 G3 box; other site 885276007934 Switch II region; other site 885276007935 G4 box; other site 885276007936 G5 box; other site 885276007937 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 885276007938 putative hexamer interface [polypeptide binding]; other site 885276007939 putative hexagonal pore; other site 885276007940 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 885276007941 Malic enzyme, N-terminal domain; Region: malic; pfam00390 885276007942 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 885276007943 putative NAD(P) binding site [chemical binding]; other site 885276007944 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 885276007945 transaldolase-like protein; Provisional; Region: PTZ00411 885276007946 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 885276007947 active site 885276007948 dimer interface [polypeptide binding]; other site 885276007949 catalytic residue [active] 885276007950 transketolase; Reviewed; Region: PRK12753 885276007951 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 885276007952 TPP-binding site [chemical binding]; other site 885276007953 dimer interface [polypeptide binding]; other site 885276007954 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885276007955 PYR/PP interface [polypeptide binding]; other site 885276007956 dimer interface [polypeptide binding]; other site 885276007957 TPP binding site [chemical binding]; other site 885276007958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885276007959 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 885276007960 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 885276007961 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 885276007962 dimer interface [polypeptide binding]; other site 885276007963 ADP-ribose binding site [chemical binding]; other site 885276007964 active site 885276007965 nudix motif; other site 885276007966 metal binding site [ion binding]; metal-binding site 885276007967 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 885276007968 4Fe-4S binding domain; Region: Fer4; pfam00037 885276007969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885276007970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276007971 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 885276007972 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 885276007973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276007974 dimerization interface [polypeptide binding]; other site 885276007975 Histidine kinase; Region: HisKA_3; pfam07730 885276007976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276007977 ATP binding site [chemical binding]; other site 885276007978 Mg2+ binding site [ion binding]; other site 885276007979 G-X-G motif; other site 885276007980 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 885276007981 Protein export membrane protein; Region: SecD_SecF; cl14618 885276007982 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 885276007983 ArsC family; Region: ArsC; pfam03960 885276007984 putative catalytic residues [active] 885276007985 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 885276007986 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 885276007987 metal binding site [ion binding]; metal-binding site 885276007988 dimer interface [polypeptide binding]; other site 885276007989 hypothetical protein; Provisional; Region: PRK13664 885276007990 putative hydrolase; Provisional; Region: PRK11460 885276007991 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 885276007992 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 885276007993 Helicase; Region: Helicase_RecD; pfam05127 885276007994 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 885276007995 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 885276007996 Predicted metalloprotease [General function prediction only]; Region: COG2321 885276007997 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 885276007998 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 885276007999 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 885276008000 ATP binding site [chemical binding]; other site 885276008001 active site 885276008002 substrate binding site [chemical binding]; other site 885276008003 lipoprotein; Provisional; Region: PRK11679 885276008004 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 885276008005 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 885276008006 dihydrodipicolinate synthase; Region: dapA; TIGR00674 885276008007 dimer interface [polypeptide binding]; other site 885276008008 active site 885276008009 catalytic residue [active] 885276008010 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 885276008011 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 885276008012 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 885276008013 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 885276008014 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 885276008015 catalytic triad [active] 885276008016 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 885276008017 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885276008018 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 885276008019 Peptidase family M48; Region: Peptidase_M48; cl12018 885276008020 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 885276008021 ArsC family; Region: ArsC; pfam03960 885276008022 catalytic residues [active] 885276008023 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 885276008024 DNA replication initiation factor; Provisional; Region: PRK08084 885276008025 uracil transporter; Provisional; Region: PRK10720 885276008026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276008027 active site 885276008028 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 885276008029 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 885276008030 dimerization interface [polypeptide binding]; other site 885276008031 putative ATP binding site [chemical binding]; other site 885276008032 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 885276008033 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 885276008034 active site 885276008035 substrate binding site [chemical binding]; other site 885276008036 cosubstrate binding site; other site 885276008037 catalytic site [active] 885276008038 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 885276008039 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 885276008040 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 885276008041 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 885276008042 domain interface [polypeptide binding]; other site 885276008043 active site 885276008044 catalytic site [active] 885276008045 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 885276008046 putative active site [active] 885276008047 catalytic site [active] 885276008048 exopolyphosphatase; Provisional; Region: PRK10854 885276008049 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 885276008050 MASE1; Region: MASE1; pfam05231 885276008051 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 885276008052 diguanylate cyclase; Region: GGDEF; smart00267 885276008053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276008054 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 885276008055 GMP synthase; Reviewed; Region: guaA; PRK00074 885276008056 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 885276008057 AMP/PPi binding site [chemical binding]; other site 885276008058 candidate oxyanion hole; other site 885276008059 catalytic triad [active] 885276008060 potential glutamine specificity residues [chemical binding]; other site 885276008061 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 885276008062 ATP Binding subdomain [chemical binding]; other site 885276008063 Ligand Binding sites [chemical binding]; other site 885276008064 Dimerization subdomain; other site 885276008065 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 885276008066 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885276008067 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 885276008068 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 885276008069 active site 885276008070 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 885276008071 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 885276008072 generic binding surface II; other site 885276008073 generic binding surface I; other site 885276008074 RatA-like protein; Provisional; Region: PRK15316 885276008075 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008076 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008077 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008078 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008079 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008080 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008081 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008082 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008083 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008084 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008085 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008086 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008087 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008088 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008089 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008090 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008091 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 885276008092 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 885276008093 intimin-like protein SinH; Provisional; Region: PRK15318 885276008094 intimin-like protein SinH; Provisional; Region: PRK15318 885276008095 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 885276008096 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 885276008097 GTP-binding protein Der; Reviewed; Region: PRK00093 885276008098 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 885276008099 G1 box; other site 885276008100 GTP/Mg2+ binding site [chemical binding]; other site 885276008101 Switch I region; other site 885276008102 G2 box; other site 885276008103 Switch II region; other site 885276008104 G3 box; other site 885276008105 G4 box; other site 885276008106 G5 box; other site 885276008107 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 885276008108 G1 box; other site 885276008109 GTP/Mg2+ binding site [chemical binding]; other site 885276008110 Switch I region; other site 885276008111 G2 box; other site 885276008112 G3 box; other site 885276008113 Switch II region; other site 885276008114 G4 box; other site 885276008115 G5 box; other site 885276008116 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 885276008117 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 885276008118 Trp docking motif [polypeptide binding]; other site 885276008119 active site 885276008120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 885276008121 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 885276008122 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 885276008123 dimer interface [polypeptide binding]; other site 885276008124 motif 1; other site 885276008125 active site 885276008126 motif 2; other site 885276008127 motif 3; other site 885276008128 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 885276008129 anticodon binding site; other site 885276008130 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 885276008131 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 885276008132 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 885276008133 cytoskeletal protein RodZ; Provisional; Region: PRK10856 885276008134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276008135 non-specific DNA binding site [nucleotide binding]; other site 885276008136 salt bridge; other site 885276008137 sequence-specific DNA binding site [nucleotide binding]; other site 885276008138 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 885276008139 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 885276008140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276008141 FeS/SAM binding site; other site 885276008142 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 885276008143 active site 885276008144 multimer interface [polypeptide binding]; other site 885276008145 penicillin-binding protein 1C; Provisional; Region: PRK11240 885276008146 Transglycosylase; Region: Transgly; pfam00912 885276008147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 885276008148 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 885276008149 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 885276008150 MG2 domain; Region: A2M_N; pfam01835 885276008151 Alpha-2-macroglobulin family; Region: A2M; pfam00207 885276008152 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 885276008153 surface patch; other site 885276008154 thioester region; other site 885276008155 specificity defining residues; other site 885276008156 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 885276008157 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 885276008158 active site residue [active] 885276008159 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 885276008160 active site residue [active] 885276008161 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 885276008162 aminopeptidase B; Provisional; Region: PRK05015 885276008163 Peptidase; Region: DUF3663; pfam12404 885276008164 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 885276008165 interface (dimer of trimers) [polypeptide binding]; other site 885276008166 Substrate-binding/catalytic site; other site 885276008167 Zn-binding sites [ion binding]; other site 885276008168 hypothetical protein; Provisional; Region: PRK10721 885276008169 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 885276008170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885276008171 catalytic loop [active] 885276008172 iron binding site [ion binding]; other site 885276008173 chaperone protein HscA; Provisional; Region: hscA; PRK05183 885276008174 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 885276008175 nucleotide binding site [chemical binding]; other site 885276008176 putative NEF/HSP70 interaction site [polypeptide binding]; other site 885276008177 SBD interface [polypeptide binding]; other site 885276008178 co-chaperone HscB; Provisional; Region: hscB; PRK05014 885276008179 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 885276008180 HSP70 interaction site [polypeptide binding]; other site 885276008181 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 885276008182 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 885276008183 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 885276008184 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 885276008185 trimerization site [polypeptide binding]; other site 885276008186 active site 885276008187 cysteine desulfurase; Provisional; Region: PRK14012 885276008188 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 885276008189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276008190 catalytic residue [active] 885276008191 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 885276008192 Rrf2 family protein; Region: rrf2_super; TIGR00738 885276008193 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 885276008194 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 885276008195 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 885276008196 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 885276008197 active site 885276008198 dimerization interface [polypeptide binding]; other site 885276008199 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 885276008200 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885276008201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885276008202 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 885276008203 PRD domain; Region: PRD; pfam00874 885276008204 PRD domain; Region: PRD; pfam00874 885276008205 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 885276008206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008207 putative substrate translocation pore; other site 885276008208 Predicted membrane protein [Function unknown]; Region: COG2259 885276008209 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 885276008210 active site 885276008211 catalytic residues [active] 885276008212 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276008213 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 885276008214 putative NAD(P) binding site [chemical binding]; other site 885276008215 catalytic Zn binding site [ion binding]; other site 885276008216 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276008217 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276008218 TM-ABC transporter signature motif; other site 885276008219 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 885276008220 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276008221 Walker A/P-loop; other site 885276008222 ATP binding site [chemical binding]; other site 885276008223 Q-loop/lid; other site 885276008224 ABC transporter signature motif; other site 885276008225 Walker B; other site 885276008226 D-loop; other site 885276008227 H-loop/switch region; other site 885276008228 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276008229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 885276008230 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 885276008231 ligand binding site [chemical binding]; other site 885276008232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276008233 TPR motif; other site 885276008234 binding surface 885276008235 TPR repeat; Region: TPR_11; pfam13414 885276008236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276008237 TPR motif; other site 885276008238 binding surface 885276008239 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 885276008240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 885276008241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276008242 nucleotide binding site [chemical binding]; other site 885276008243 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 885276008244 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 885276008245 dimer interface [polypeptide binding]; other site 885276008246 active site 885276008247 glycine-pyridoxal phosphate binding site [chemical binding]; other site 885276008248 folate binding site [chemical binding]; other site 885276008249 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 885276008250 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 885276008251 heme-binding site [chemical binding]; other site 885276008252 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 885276008253 FAD binding pocket [chemical binding]; other site 885276008254 FAD binding motif [chemical binding]; other site 885276008255 phosphate binding motif [ion binding]; other site 885276008256 beta-alpha-beta structure motif; other site 885276008257 NAD binding pocket [chemical binding]; other site 885276008258 Heme binding pocket [chemical binding]; other site 885276008259 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 885276008260 Nitrogen regulatory protein P-II; Region: P-II; smart00938 885276008261 response regulator GlrR; Provisional; Region: PRK15115 885276008262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276008263 active site 885276008264 phosphorylation site [posttranslational modification] 885276008265 intermolecular recognition site; other site 885276008266 dimerization interface [polypeptide binding]; other site 885276008267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008268 Walker A motif; other site 885276008269 ATP binding site [chemical binding]; other site 885276008270 Walker B motif; other site 885276008271 arginine finger; other site 885276008272 hypothetical protein; Provisional; Region: PRK10722 885276008273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 885276008274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276008275 dimer interface [polypeptide binding]; other site 885276008276 phosphorylation site [posttranslational modification] 885276008277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276008278 ATP binding site [chemical binding]; other site 885276008279 Mg2+ binding site [ion binding]; other site 885276008280 G-X-G motif; other site 885276008281 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 885276008282 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 885276008283 dimerization interface [polypeptide binding]; other site 885276008284 ATP binding site [chemical binding]; other site 885276008285 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 885276008286 dimerization interface [polypeptide binding]; other site 885276008287 ATP binding site [chemical binding]; other site 885276008288 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 885276008289 putative active site [active] 885276008290 catalytic triad [active] 885276008291 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 885276008292 nucleoside/Zn binding site; other site 885276008293 dimer interface [polypeptide binding]; other site 885276008294 catalytic motif [active] 885276008295 hypothetical protein; Provisional; Region: PRK11590 885276008296 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 885276008297 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885276008298 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 885276008299 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885276008300 putative active site [active] 885276008301 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 885276008302 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 885276008303 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 885276008304 active site 885276008305 hydrophilic channel; other site 885276008306 dimerization interface [polypeptide binding]; other site 885276008307 catalytic residues [active] 885276008308 active site lid [active] 885276008309 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 885276008310 Recombination protein O N terminal; Region: RecO_N; pfam11967 885276008311 Recombination protein O C terminal; Region: RecO_C; pfam02565 885276008312 GTPase Era; Reviewed; Region: era; PRK00089 885276008313 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 885276008314 G1 box; other site 885276008315 GTP/Mg2+ binding site [chemical binding]; other site 885276008316 Switch I region; other site 885276008317 G2 box; other site 885276008318 Switch II region; other site 885276008319 G3 box; other site 885276008320 G4 box; other site 885276008321 G5 box; other site 885276008322 KH domain; Region: KH_2; pfam07650 885276008323 ribonuclease III; Reviewed; Region: rnc; PRK00102 885276008324 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 885276008325 dimerization interface [polypeptide binding]; other site 885276008326 active site 885276008327 metal binding site [ion binding]; metal-binding site 885276008328 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 885276008329 dsRNA binding site [nucleotide binding]; other site 885276008330 signal peptidase I; Provisional; Region: PRK10861 885276008331 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 885276008332 Catalytic site [active] 885276008333 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 885276008334 GTP-binding protein LepA; Provisional; Region: PRK05433 885276008335 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 885276008336 G1 box; other site 885276008337 putative GEF interaction site [polypeptide binding]; other site 885276008338 GTP/Mg2+ binding site [chemical binding]; other site 885276008339 Switch I region; other site 885276008340 G2 box; other site 885276008341 G3 box; other site 885276008342 Switch II region; other site 885276008343 G4 box; other site 885276008344 G5 box; other site 885276008345 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 885276008346 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 885276008347 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 885276008348 SoxR reducing system protein RseC; Provisional; Region: PRK10862 885276008349 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 885276008350 anti-sigma E factor; Provisional; Region: rseB; PRK09455 885276008351 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 885276008352 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 885276008353 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 885276008354 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 885276008355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885276008356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885276008357 DNA binding residues [nucleotide binding] 885276008358 L-aspartate oxidase; Provisional; Region: PRK09077 885276008359 L-aspartate oxidase; Provisional; Region: PRK06175 885276008360 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 885276008361 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 885276008362 Methyltransferase domain; Region: Methyltransf_26; pfam13659 885276008363 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 885276008364 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885276008365 ATP binding site [chemical binding]; other site 885276008366 Mg++ binding site [ion binding]; other site 885276008367 motif III; other site 885276008368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276008369 nucleotide binding region [chemical binding]; other site 885276008370 ATP-binding site [chemical binding]; other site 885276008371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276008372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276008373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 885276008374 dimerization interface [polypeptide binding]; other site 885276008375 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 885276008376 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 885276008377 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 885276008378 ligand binding site [chemical binding]; other site 885276008379 active site 885276008380 UGI interface [polypeptide binding]; other site 885276008381 catalytic site [active] 885276008382 putative methyltransferase; Provisional; Region: PRK10864 885276008383 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 885276008384 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 885276008385 thioredoxin 2; Provisional; Region: PRK10996 885276008386 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 885276008387 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 885276008388 catalytic residues [active] 885276008389 Uncharacterized conserved protein [Function unknown]; Region: COG3148 885276008390 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 885276008391 CoA binding domain; Region: CoA_binding_2; pfam13380 885276008392 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 885276008393 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 885276008394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 885276008395 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 885276008396 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 885276008397 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 885276008398 domain interface [polypeptide binding]; other site 885276008399 putative active site [active] 885276008400 catalytic site [active] 885276008401 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 885276008402 domain interface [polypeptide binding]; other site 885276008403 putative active site [active] 885276008404 catalytic site [active] 885276008405 lipoprotein; Provisional; Region: PRK10759 885276008406 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 885276008407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008408 putative substrate translocation pore; other site 885276008409 protein disaggregation chaperone; Provisional; Region: PRK10865 885276008410 Clp amino terminal domain; Region: Clp_N; pfam02861 885276008411 Clp amino terminal domain; Region: Clp_N; pfam02861 885276008412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008413 Walker A motif; other site 885276008414 ATP binding site [chemical binding]; other site 885276008415 Walker B motif; other site 885276008416 arginine finger; other site 885276008417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008418 Walker A motif; other site 885276008419 ATP binding site [chemical binding]; other site 885276008420 Walker B motif; other site 885276008421 arginine finger; other site 885276008422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 885276008423 hypothetical protein; Provisional; Region: PRK10723 885276008424 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 885276008425 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 885276008426 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276008427 RNA binding surface [nucleotide binding]; other site 885276008428 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 885276008429 active site 885276008430 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 885276008431 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 885276008432 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 885276008433 30S subunit binding site; other site 885276008434 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 885276008435 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 885276008436 Prephenate dehydratase; Region: PDT; pfam00800 885276008437 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 885276008438 putative L-Phe binding site [chemical binding]; other site 885276008439 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 885276008440 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 885276008441 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 885276008442 prephenate dehydrogenase; Validated; Region: PRK08507 885276008443 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 885276008444 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 885276008445 lipoprotein; Provisional; Region: PRK11443 885276008446 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 885276008447 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 885276008448 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 885276008449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276008450 metal binding site [ion binding]; metal-binding site 885276008451 active site 885276008452 I-site; other site 885276008453 putative outer membrane lipoprotein; Provisional; Region: PRK09967 885276008454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276008455 ligand binding site [chemical binding]; other site 885276008456 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 885276008457 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 885276008458 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 885276008459 RimM N-terminal domain; Region: RimM; pfam01782 885276008460 PRC-barrel domain; Region: PRC; pfam05239 885276008461 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 885276008462 signal recognition particle protein; Provisional; Region: PRK10867 885276008463 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 885276008464 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 885276008465 P loop; other site 885276008466 GTP binding site [chemical binding]; other site 885276008467 Signal peptide binding domain; Region: SRP_SPB; pfam02978 885276008468 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 885276008469 hypothetical protein; Provisional; Region: PRK11573 885276008470 Domain of unknown function DUF21; Region: DUF21; pfam01595 885276008471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885276008472 Transporter associated domain; Region: CorC_HlyC; smart01091 885276008473 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 885276008474 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 885276008475 dimer interface [polypeptide binding]; other site 885276008476 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 885276008477 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 885276008478 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 885276008479 recombination and repair protein; Provisional; Region: PRK10869 885276008480 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 885276008481 Walker A/P-loop; other site 885276008482 ATP binding site [chemical binding]; other site 885276008483 Q-loop/lid; other site 885276008484 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 885276008485 Q-loop/lid; other site 885276008486 ABC transporter signature motif; other site 885276008487 Walker B; other site 885276008488 D-loop; other site 885276008489 H-loop/switch region; other site 885276008490 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 885276008491 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 885276008492 hypothetical protein; Validated; Region: PRK01777 885276008493 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 885276008494 putative coenzyme Q binding site [chemical binding]; other site 885276008495 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 885276008496 SmpB-tmRNA interface; other site 885276008497 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 885276008498 substrate binding pocket [chemical binding]; other site 885276008499 active site 885276008500 iron coordination sites [ion binding]; other site 885276008501 Predicted dehydrogenase [General function prediction only]; Region: COG0579 885276008502 hydroxyglutarate oxidase; Provisional; Region: PRK11728 885276008503 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 885276008504 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 885276008505 tetramerization interface [polypeptide binding]; other site 885276008506 NAD(P) binding site [chemical binding]; other site 885276008507 catalytic residues [active] 885276008508 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 885276008509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885276008510 inhibitor-cofactor binding pocket; inhibition site 885276008511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276008512 catalytic residue [active] 885276008513 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 885276008514 TMPIT-like protein; Region: TMPIT; pfam07851 885276008515 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 885276008516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276008517 DNA-binding site [nucleotide binding]; DNA binding site 885276008518 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276008519 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 885276008520 bacterial OsmY and nodulation domain; Region: BON; smart00749 885276008521 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276008522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276008523 dimerization interface [polypeptide binding]; other site 885276008524 putative DNA binding site [nucleotide binding]; other site 885276008525 putative Zn2+ binding site [ion binding]; other site 885276008526 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 885276008527 active site residue [active] 885276008528 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 885276008529 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 885276008530 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 885276008531 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 885276008532 hypothetical protein; Provisional; Region: PRK10556 885276008533 hypothetical protein; Provisional; Region: PRK10132 885276008534 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 885276008535 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276008536 DNA-binding site [nucleotide binding]; DNA binding site 885276008537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276008538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276008539 homodimer interface [polypeptide binding]; other site 885276008540 catalytic residue [active] 885276008541 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 885276008542 Uncharacterized conserved protein [Function unknown]; Region: COG2128 885276008543 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 885276008544 catalytic residues [active] 885276008545 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 885276008546 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 885276008547 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 885276008548 Class I ribonucleotide reductase; Region: RNR_I; cd01679 885276008549 active site 885276008550 dimer interface [polypeptide binding]; other site 885276008551 catalytic residues [active] 885276008552 effector binding site; other site 885276008553 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 885276008554 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 885276008555 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 885276008556 dimer interface [polypeptide binding]; other site 885276008557 putative radical transfer pathway; other site 885276008558 diiron center [ion binding]; other site 885276008559 tyrosyl radical; other site 885276008560 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 885276008561 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 885276008562 Walker A/P-loop; other site 885276008563 ATP binding site [chemical binding]; other site 885276008564 Q-loop/lid; other site 885276008565 ABC transporter signature motif; other site 885276008566 Walker B; other site 885276008567 D-loop; other site 885276008568 H-loop/switch region; other site 885276008569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 885276008570 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 885276008571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276008572 dimer interface [polypeptide binding]; other site 885276008573 conserved gate region; other site 885276008574 putative PBP binding loops; other site 885276008575 ABC-ATPase subunit interface; other site 885276008576 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 885276008577 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 885276008578 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 885276008579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008580 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 885276008581 putative L-valine exporter; Provisional; Region: PRK10408 885276008582 transcriptional repressor MprA; Provisional; Region: PRK10870 885276008583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885276008584 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 885276008585 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276008586 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276008587 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 885276008588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008589 putative substrate translocation pore; other site 885276008590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008591 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885276008592 Zn2+ binding site [ion binding]; other site 885276008593 Mg2+ binding site [ion binding]; other site 885276008594 AAA domain; Region: AAA_33; pfam13671 885276008595 S-ribosylhomocysteinase; Provisional; Region: PRK02260 885276008596 glutamate--cysteine ligase; Provisional; Region: PRK02107 885276008597 Predicted membrane protein [Function unknown]; Region: COG1238 885276008598 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 885276008599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276008600 motif II; other site 885276008601 carbon storage regulator; Provisional; Region: PRK01712 885276008602 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 885276008603 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 885276008604 motif 1; other site 885276008605 active site 885276008606 motif 2; other site 885276008607 motif 3; other site 885276008608 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 885276008609 DHHA1 domain; Region: DHHA1; pfam02272 885276008610 recombination regulator RecX; Reviewed; Region: recX; PRK00117 885276008611 recombinase A; Provisional; Region: recA; PRK09354 885276008612 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 885276008613 hexamer interface [polypeptide binding]; other site 885276008614 Walker A motif; other site 885276008615 ATP binding site [chemical binding]; other site 885276008616 Walker B motif; other site 885276008617 hypothetical protein; Validated; Region: PRK03661 885276008618 Transglycosylase SLT domain; Region: SLT_2; pfam13406 885276008619 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885276008620 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885276008621 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 885276008622 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 885276008623 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 885276008624 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 885276008625 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 885276008626 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 885276008627 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 885276008628 putative NAD(P) binding site [chemical binding]; other site 885276008629 active site 885276008630 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 885276008631 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 885276008632 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276008633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276008634 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 885276008635 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885276008636 putative active site [active] 885276008637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 885276008638 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 885276008639 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885276008640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008641 Walker A motif; other site 885276008642 ATP binding site [chemical binding]; other site 885276008643 Walker B motif; other site 885276008644 arginine finger; other site 885276008645 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 885276008646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885276008647 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 885276008648 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 885276008649 iron binding site [ion binding]; other site 885276008650 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 885276008651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276008652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276008653 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 885276008654 Acylphosphatase; Region: Acylphosphatase; pfam00708 885276008655 HypF finger; Region: zf-HYPF; pfam07503 885276008656 HypF finger; Region: zf-HYPF; pfam07503 885276008657 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 885276008658 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 885276008659 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 885276008660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276008661 non-specific DNA binding site [nucleotide binding]; other site 885276008662 salt bridge; other site 885276008663 sequence-specific DNA binding site [nucleotide binding]; other site 885276008664 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 885276008665 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 885276008666 nickel binding site [ion binding]; other site 885276008667 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 885276008668 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 885276008669 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 885276008670 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276008671 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 885276008672 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 885276008673 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 885276008674 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 885276008675 NADH dehydrogenase; Region: NADHdh; cl00469 885276008676 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 885276008677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 885276008678 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 885276008679 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 885276008680 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 885276008681 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 885276008682 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 885276008683 hydrogenase assembly chaperone; Provisional; Region: PRK10409 885276008684 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 885276008685 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 885276008686 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 885276008687 dimerization interface [polypeptide binding]; other site 885276008688 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 885276008689 ATP binding site [chemical binding]; other site 885276008690 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 885276008691 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885276008692 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885276008693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008694 Walker A motif; other site 885276008695 ATP binding site [chemical binding]; other site 885276008696 Walker B motif; other site 885276008697 arginine finger; other site 885276008698 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 885276008699 molybdenum-pterin binding domain; Region: Mop; TIGR00638 885276008700 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 885276008701 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 885276008702 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 885276008703 MutS domain I; Region: MutS_I; pfam01624 885276008704 MutS domain II; Region: MutS_II; pfam05188 885276008705 MutS domain III; Region: MutS_III; pfam05192 885276008706 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 885276008707 Walker A/P-loop; other site 885276008708 ATP binding site [chemical binding]; other site 885276008709 Q-loop/lid; other site 885276008710 ABC transporter signature motif; other site 885276008711 Walker B; other site 885276008712 D-loop; other site 885276008713 H-loop/switch region; other site 885276008714 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 885276008715 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885276008716 active site 885276008717 metal binding site [ion binding]; metal-binding site 885276008718 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276008719 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276008720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276008721 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 885276008722 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885276008723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 885276008724 putative aldolase; Validated; Region: PRK08130 885276008725 active site 885276008726 intersubunit interface [polypeptide binding]; other site 885276008727 Zn2+ binding site [ion binding]; other site 885276008728 hypothetical protein; Provisional; Region: PRK09989 885276008729 putative transporter; Provisional; Region: PRK09821 885276008730 GntP family permease; Region: GntP_permease; pfam02447 885276008731 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885276008732 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 885276008733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885276008734 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 885276008735 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 885276008736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885276008737 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 885276008738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885276008739 DNA binding residues [nucleotide binding] 885276008740 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 885276008741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276008742 Peptidase family M23; Region: Peptidase_M23; pfam01551 885276008743 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 885276008744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276008745 S-adenosylmethionine binding site [chemical binding]; other site 885276008746 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 885276008747 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 885276008748 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 885276008749 Permutation of conserved domain; other site 885276008750 active site 885276008751 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 885276008752 homotrimer interaction site [polypeptide binding]; other site 885276008753 zinc binding site [ion binding]; other site 885276008754 CDP-binding sites; other site 885276008755 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 885276008756 substrate binding site; other site 885276008757 dimer interface; other site 885276008758 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 885276008759 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 885276008760 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 885276008761 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 885276008762 ligand-binding site [chemical binding]; other site 885276008763 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 885276008764 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 885276008765 CysD dimerization site [polypeptide binding]; other site 885276008766 G1 box; other site 885276008767 putative GEF interaction site [polypeptide binding]; other site 885276008768 GTP/Mg2+ binding site [chemical binding]; other site 885276008769 Switch I region; other site 885276008770 G2 box; other site 885276008771 G3 box; other site 885276008772 Switch II region; other site 885276008773 G4 box; other site 885276008774 G5 box; other site 885276008775 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 885276008776 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 885276008777 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 885276008778 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885276008779 Active Sites [active] 885276008780 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 885276008781 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 885276008782 metal binding site [ion binding]; metal-binding site 885276008783 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 885276008784 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 885276008785 Active Sites [active] 885276008786 sulfite reductase subunit beta; Provisional; Region: PRK13504 885276008787 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 885276008788 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 885276008789 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 885276008790 Flavodoxin; Region: Flavodoxin_1; pfam00258 885276008791 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 885276008792 FAD binding pocket [chemical binding]; other site 885276008793 FAD binding motif [chemical binding]; other site 885276008794 catalytic residues [active] 885276008795 NAD binding pocket [chemical binding]; other site 885276008796 phosphate binding motif [ion binding]; other site 885276008797 beta-alpha-beta structure motif; other site 885276008798 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 885276008799 homohexamer interface [polypeptide binding]; other site 885276008800 putative substrate stabilizing pore; other site 885276008801 pterin binding site; other site 885276008802 FAD dependent oxidoreductase; Region: DAO; pfam01266 885276008803 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 885276008804 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 885276008805 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 885276008806 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 885276008807 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 885276008808 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 885276008809 Ligand binding site [chemical binding]; other site 885276008810 Electron transfer flavoprotein domain; Region: ETF; pfam01012 885276008811 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 885276008812 benzoate transport; Region: 2A0115; TIGR00895 885276008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008814 putative substrate translocation pore; other site 885276008815 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 885276008816 FAD binding domain; Region: FAD_binding_4; pfam01565 885276008817 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 885276008818 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885276008819 NADP binding site [chemical binding]; other site 885276008820 homodimer interface [polypeptide binding]; other site 885276008821 active site 885276008822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276008823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008824 putative substrate translocation pore; other site 885276008825 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 885276008826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885276008827 nucleotide binding site [chemical binding]; other site 885276008828 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 885276008829 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 885276008830 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 885276008831 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 885276008832 Repair protein; Region: Repair_PSII; pfam04536 885276008833 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 885276008834 Repair protein; Region: Repair_PSII; pfam04536 885276008835 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 885276008836 Repair protein; Region: Repair_PSII; pfam04536 885276008837 enolase; Provisional; Region: eno; PRK00077 885276008838 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 885276008839 dimer interface [polypeptide binding]; other site 885276008840 metal binding site [ion binding]; metal-binding site 885276008841 substrate binding pocket [chemical binding]; other site 885276008842 CTP synthetase; Validated; Region: pyrG; PRK05380 885276008843 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 885276008844 Catalytic site [active] 885276008845 active site 885276008846 UTP binding site [chemical binding]; other site 885276008847 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 885276008848 active site 885276008849 putative oxyanion hole; other site 885276008850 catalytic triad [active] 885276008851 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 885276008852 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 885276008853 homodimer interface [polypeptide binding]; other site 885276008854 metal binding site [ion binding]; metal-binding site 885276008855 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 885276008856 homodimer interface [polypeptide binding]; other site 885276008857 active site 885276008858 putative chemical substrate binding site [chemical binding]; other site 885276008859 metal binding site [ion binding]; metal-binding site 885276008860 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 885276008861 HD domain; Region: HD_4; pfam13328 885276008862 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 885276008863 synthetase active site [active] 885276008864 NTP binding site [chemical binding]; other site 885276008865 metal binding site [ion binding]; metal-binding site 885276008866 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 885276008867 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 885276008868 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 885276008869 TRAM domain; Region: TRAM; pfam01938 885276008870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276008871 S-adenosylmethionine binding site [chemical binding]; other site 885276008872 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 885276008873 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 885276008874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276008875 dimerization interface [polypeptide binding]; other site 885276008876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276008877 dimer interface [polypeptide binding]; other site 885276008878 phosphorylation site [posttranslational modification] 885276008879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276008880 ATP binding site [chemical binding]; other site 885276008881 Mg2+ binding site [ion binding]; other site 885276008882 G-X-G motif; other site 885276008883 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 885276008884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276008885 active site 885276008886 phosphorylation site [posttranslational modification] 885276008887 intermolecular recognition site; other site 885276008888 dimerization interface [polypeptide binding]; other site 885276008889 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885276008890 putative binding surface; other site 885276008891 active site 885276008892 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 885276008893 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 885276008894 active site 885276008895 tetramer interface [polypeptide binding]; other site 885276008896 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 885276008897 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 885276008898 active site 885276008899 tetramer interface [polypeptide binding]; other site 885276008900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008901 D-galactonate transporter; Region: 2A0114; TIGR00893 885276008902 putative substrate translocation pore; other site 885276008903 flavodoxin; Provisional; Region: PRK08105 885276008904 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 885276008905 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 885276008906 probable active site [active] 885276008907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 885276008908 SecY interacting protein Syd; Provisional; Region: PRK04968 885276008909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 885276008910 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 885276008911 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 885276008912 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 885276008913 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 885276008914 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885276008915 serine transporter; Region: stp; TIGR00814 885276008916 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 885276008917 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 885276008918 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 885276008919 flap endonuclease-like protein; Provisional; Region: PRK09482 885276008920 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 885276008921 active site 885276008922 metal binding site 1 [ion binding]; metal-binding site 885276008923 putative 5' ssDNA interaction site; other site 885276008924 metal binding site 3; metal-binding site 885276008925 metal binding site 2 [ion binding]; metal-binding site 885276008926 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 885276008927 putative DNA binding site [nucleotide binding]; other site 885276008928 putative metal binding site [ion binding]; other site 885276008929 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 885276008930 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 885276008931 dimer interface [polypeptide binding]; other site 885276008932 active site 885276008933 metal binding site [ion binding]; metal-binding site 885276008934 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885276008935 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885276008936 intersubunit interface [polypeptide binding]; other site 885276008937 active site 885276008938 Zn2+ binding site [ion binding]; other site 885276008939 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 885276008940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276008941 putative substrate translocation pore; other site 885276008942 L-fucose isomerase; Provisional; Region: fucI; PRK10991 885276008943 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 885276008944 hexamer (dimer of trimers) interface [polypeptide binding]; other site 885276008945 trimer interface [polypeptide binding]; other site 885276008946 substrate binding site [chemical binding]; other site 885276008947 Mn binding site [ion binding]; other site 885276008948 L-fuculokinase; Provisional; Region: PRK10331 885276008949 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885276008950 nucleotide binding site [chemical binding]; other site 885276008951 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 885276008952 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 885276008953 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276008954 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276008955 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 885276008956 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 885276008957 hypothetical protein; Provisional; Region: PRK10873 885276008958 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 885276008959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276008960 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 885276008961 dimerization interface [polypeptide binding]; other site 885276008962 substrate binding pocket [chemical binding]; other site 885276008963 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 885276008964 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 885276008965 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 885276008966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276008967 catalytic residue [active] 885276008968 CsdA-binding activator; Provisional; Region: PRK15019 885276008969 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 885276008970 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 885276008971 putative ATP binding site [chemical binding]; other site 885276008972 putative substrate interface [chemical binding]; other site 885276008973 murein transglycosylase A; Provisional; Region: mltA; PRK11162 885276008974 MltA specific insert domain; Region: MltA; pfam03562 885276008975 3D domain; Region: 3D; pfam06725 885276008976 Protein of unknown function (DUF770); Region: DUF770; pfam05591 885276008977 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 885276008978 Protein of unknown function (DUF877); Region: DUF877; pfam05943 885276008979 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 885276008980 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 885276008981 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 885276008982 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 885276008983 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276008984 ligand binding site [chemical binding]; other site 885276008985 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 885276008986 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 885276008987 Clp amino terminal domain; Region: Clp_N; pfam02861 885276008988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008989 Walker A motif; other site 885276008990 ATP binding site [chemical binding]; other site 885276008991 Walker B motif; other site 885276008992 arginine finger; other site 885276008993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276008994 Walker A motif; other site 885276008995 ATP binding site [chemical binding]; other site 885276008996 Walker B motif; other site 885276008997 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 885276008998 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 885276008999 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 885276009000 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 885276009001 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 885276009002 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 885276009003 PAAR motif; Region: PAAR_motif; pfam05488 885276009004 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 885276009005 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 885276009006 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 885276009007 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 885276009008 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 885276009009 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 885276009010 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 885276009011 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 885276009012 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 885276009013 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 885276009014 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 885276009015 ImpA domain protein; Region: DUF3702; pfam12486 885276009016 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 885276009017 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 885276009018 putative ligand binding site [chemical binding]; other site 885276009019 putative NAD binding site [chemical binding]; other site 885276009020 catalytic site [active] 885276009021 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885276009022 putative active site [active] 885276009023 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 885276009024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276009025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276009026 homodimer interface [polypeptide binding]; other site 885276009027 catalytic residue [active] 885276009028 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 885276009029 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276009030 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276009031 active site turn [active] 885276009032 phosphorylation site [posttranslational modification] 885276009033 CAT RNA binding domain; Region: CAT_RBD; pfam03123 885276009034 PRD domain; Region: PRD; pfam00874 885276009035 PRD domain; Region: PRD; pfam00874 885276009036 AMIN domain; Region: AMIN; pfam11741 885276009037 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 885276009038 active site 885276009039 metal binding site [ion binding]; metal-binding site 885276009040 N-acetylglutamate synthase; Validated; Region: PRK05279 885276009041 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 885276009042 putative feedback inhibition sensing region; other site 885276009043 putative nucleotide binding site [chemical binding]; other site 885276009044 putative substrate binding site [chemical binding]; other site 885276009045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276009046 Coenzyme A binding pocket [chemical binding]; other site 885276009047 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 885276009048 AAA domain; Region: AAA_30; pfam13604 885276009049 Family description; Region: UvrD_C_2; pfam13538 885276009050 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 885276009051 protease3; Provisional; Region: PRK15101 885276009052 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 885276009053 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885276009054 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885276009055 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 885276009056 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 885276009057 hypothetical protein; Provisional; Region: PRK10332 885276009058 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 885276009059 hypothetical protein; Provisional; Region: PRK11521 885276009060 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885276009061 hypothetical protein; Provisional; Region: PRK10557 885276009062 hypothetical protein; Provisional; Region: PRK10506 885276009063 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885276009064 thymidylate synthase; Reviewed; Region: thyA; PRK01827 885276009065 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 885276009066 dimerization interface [polypeptide binding]; other site 885276009067 active site 885276009068 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 885276009069 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 885276009070 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 885276009071 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885276009072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885276009073 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885276009074 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 885276009075 putative active site [active] 885276009076 Ap4A binding site [chemical binding]; other site 885276009077 nudix motif; other site 885276009078 putative metal binding site [ion binding]; other site 885276009079 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 885276009080 putative DNA-binding cleft [nucleotide binding]; other site 885276009081 putative DNA clevage site; other site 885276009082 molecular lever; other site 885276009083 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 885276009084 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 885276009085 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276009086 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276009087 active site 885276009088 catalytic tetrad [active] 885276009089 lysophospholipid transporter LplT; Provisional; Region: PRK11195 885276009090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009091 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 885276009092 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 885276009093 putative acyl-acceptor binding pocket; other site 885276009094 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 885276009095 acyl-activating enzyme (AAE) consensus motif; other site 885276009096 putative AMP binding site [chemical binding]; other site 885276009097 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 885276009098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276009099 DNA binding site [nucleotide binding] 885276009100 domain linker motif; other site 885276009101 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 885276009102 dimerization interface (closed form) [polypeptide binding]; other site 885276009103 ligand binding site [chemical binding]; other site 885276009104 diaminopimelate decarboxylase; Provisional; Region: PRK11165 885276009105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 885276009106 active site 885276009107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885276009108 substrate binding site [chemical binding]; other site 885276009109 catalytic residues [active] 885276009110 dimer interface [polypeptide binding]; other site 885276009111 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 885276009112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276009113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276009114 dimerization interface [polypeptide binding]; other site 885276009115 putative racemase; Provisional; Region: PRK10200 885276009116 aspartate racemase; Region: asp_race; TIGR00035 885276009117 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 885276009118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009119 putative substrate translocation pore; other site 885276009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009121 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 885276009122 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885276009123 NADP binding site [chemical binding]; other site 885276009124 homodimer interface [polypeptide binding]; other site 885276009125 active site 885276009126 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 885276009127 putative acyltransferase; Provisional; Region: PRK05790 885276009128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885276009129 dimer interface [polypeptide binding]; other site 885276009130 active site 885276009131 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885276009132 serine transporter; Region: stp; TIGR00814 885276009133 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 885276009134 Peptidase family M23; Region: Peptidase_M23; pfam01551 885276009135 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 885276009136 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 885276009137 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 885276009138 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 885276009139 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 885276009140 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 885276009141 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 885276009142 catalytic loop [active] 885276009143 iron binding site [ion binding]; other site 885276009144 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 885276009145 GAF domain; Region: GAF; cl17456 885276009146 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 885276009147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276009148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276009149 Walker A motif; other site 885276009150 ATP binding site [chemical binding]; other site 885276009151 Walker B motif; other site 885276009152 arginine finger; other site 885276009153 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276009154 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 885276009155 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885276009156 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885276009157 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 885276009158 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 885276009159 catalytic residue [active] 885276009160 peptidase; Reviewed; Region: PRK13004 885276009161 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 885276009162 putative metal binding site [ion binding]; other site 885276009163 putative dimer interface [polypeptide binding]; other site 885276009164 D-hydantoinase; Region: D-hydantoinase; TIGR02033 885276009165 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 885276009166 tetramer interface [polypeptide binding]; other site 885276009167 active site 885276009168 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885276009169 carbamate kinase; Reviewed; Region: PRK12686 885276009170 putative substrate binding site [chemical binding]; other site 885276009171 homodimer interface [polypeptide binding]; other site 885276009172 nucleotide binding site [chemical binding]; other site 885276009173 nucleotide binding site [chemical binding]; other site 885276009174 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 885276009175 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 885276009176 XdhC Rossmann domain; Region: XdhC_C; pfam13478 885276009177 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 885276009178 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 885276009179 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 885276009180 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 885276009181 Ligand binding site; other site 885276009182 metal-binding site 885276009183 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 885276009184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885276009185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276009186 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 885276009187 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 885276009188 active site 885276009189 putative substrate binding pocket [chemical binding]; other site 885276009190 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 885276009191 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 885276009192 putative hypoxanthine oxidase; Provisional; Region: PRK09800 885276009193 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 885276009194 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 885276009195 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 885276009196 uracil-xanthine permease; Region: ncs2; TIGR00801 885276009197 guanine deaminase; Provisional; Region: PRK09228 885276009198 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 885276009199 active site 885276009200 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885276009201 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 885276009202 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 885276009203 4Fe-4S binding domain; Region: Fer4; pfam00037 885276009204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 885276009205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276009206 xanthine permease; Region: pbuX; TIGR03173 885276009207 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 885276009208 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 885276009209 active site 885276009210 metal binding site [ion binding]; metal-binding site 885276009211 nudix motif; other site 885276009212 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 885276009213 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 885276009214 dimer interface [polypeptide binding]; other site 885276009215 putative anticodon binding site; other site 885276009216 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 885276009217 motif 1; other site 885276009218 active site 885276009219 motif 2; other site 885276009220 motif 3; other site 885276009221 peptide chain release factor 2; Provisional; Region: PRK08787 885276009222 This domain is found in peptide chain release factors; Region: PCRF; smart00937 885276009223 RF-1 domain; Region: RF-1; pfam00472 885276009224 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 885276009225 DHH family; Region: DHH; pfam01368 885276009226 DHHA1 domain; Region: DHHA1; pfam02272 885276009227 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 885276009228 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 885276009229 dimerization domain [polypeptide binding]; other site 885276009230 dimer interface [polypeptide binding]; other site 885276009231 catalytic residues [active] 885276009232 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 885276009233 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 885276009234 active site 885276009235 Int/Topo IB signature motif; other site 885276009236 flavodoxin FldB; Provisional; Region: PRK12359 885276009237 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 885276009238 hypothetical protein; Provisional; Region: PRK10878 885276009239 putative global regulator; Reviewed; Region: PRK09559 885276009240 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 885276009241 hemolysin; Provisional; Region: PRK15087 885276009242 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 885276009243 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 885276009244 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 885276009245 beta-galactosidase; Region: BGL; TIGR03356 885276009246 glycine dehydrogenase; Provisional; Region: PRK05367 885276009247 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 885276009248 tetramer interface [polypeptide binding]; other site 885276009249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276009250 catalytic residue [active] 885276009251 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 885276009252 tetramer interface [polypeptide binding]; other site 885276009253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276009254 catalytic residue [active] 885276009255 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 885276009256 lipoyl attachment site [posttranslational modification]; other site 885276009257 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 885276009258 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 885276009259 oxidoreductase; Provisional; Region: PRK08013 885276009260 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 885276009261 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 885276009262 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 885276009263 proline aminopeptidase P II; Provisional; Region: PRK10879 885276009264 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 885276009265 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 885276009266 active site 885276009267 hypothetical protein; Reviewed; Region: PRK01736 885276009268 Z-ring-associated protein; Provisional; Region: PRK10972 885276009269 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 885276009270 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 885276009271 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 885276009272 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 885276009273 ligand binding site [chemical binding]; other site 885276009274 NAD binding site [chemical binding]; other site 885276009275 tetramer interface [polypeptide binding]; other site 885276009276 catalytic site [active] 885276009277 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 885276009278 L-serine binding site [chemical binding]; other site 885276009279 ACT domain interface; other site 885276009280 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 885276009281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885276009282 active site 885276009283 dimer interface [polypeptide binding]; other site 885276009284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276009285 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 885276009286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276009287 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 885276009288 putative dimerization interface [polypeptide binding]; other site 885276009289 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 885276009290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276009291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276009292 Uncharacterized conserved protein [Function unknown]; Region: COG2968 885276009293 oxidative stress defense protein; Provisional; Region: PRK11087 885276009294 arginine exporter protein; Provisional; Region: PRK09304 885276009295 mechanosensitive channel MscS; Provisional; Region: PRK10334 885276009296 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885276009297 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885276009298 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 885276009299 active site 885276009300 intersubunit interface [polypeptide binding]; other site 885276009301 zinc binding site [ion binding]; other site 885276009302 Na+ binding site [ion binding]; other site 885276009303 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 885276009304 Phosphoglycerate kinase; Region: PGK; pfam00162 885276009305 substrate binding site [chemical binding]; other site 885276009306 hinge regions; other site 885276009307 ADP binding site [chemical binding]; other site 885276009308 catalytic site [active] 885276009309 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 885276009310 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 885276009311 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 885276009312 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 885276009313 trimer interface [polypeptide binding]; other site 885276009314 putative Zn binding site [ion binding]; other site 885276009315 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 885276009316 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 885276009317 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 885276009318 Walker A/P-loop; other site 885276009319 ATP binding site [chemical binding]; other site 885276009320 Q-loop/lid; other site 885276009321 ABC transporter signature motif; other site 885276009322 Walker B; other site 885276009323 D-loop; other site 885276009324 H-loop/switch region; other site 885276009325 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 885276009326 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 885276009327 Walker A/P-loop; other site 885276009328 ATP binding site [chemical binding]; other site 885276009329 Q-loop/lid; other site 885276009330 ABC transporter signature motif; other site 885276009331 Walker B; other site 885276009332 D-loop; other site 885276009333 H-loop/switch region; other site 885276009334 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 885276009335 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 885276009336 active site 885276009337 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 885276009338 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 885276009339 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 885276009340 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 885276009341 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276009342 putative NAD(P) binding site [chemical binding]; other site 885276009343 catalytic Zn binding site [ion binding]; other site 885276009344 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 885276009345 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 885276009346 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 885276009347 active site 885276009348 P-loop; other site 885276009349 phosphorylation site [posttranslational modification] 885276009350 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276009351 active site 885276009352 phosphorylation site [posttranslational modification] 885276009353 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 885276009354 SPFH domain / Band 7 family; Region: Band_7; pfam01145 885276009355 transketolase; Reviewed; Region: PRK12753 885276009356 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 885276009357 TPP-binding site [chemical binding]; other site 885276009358 dimer interface [polypeptide binding]; other site 885276009359 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885276009360 PYR/PP interface [polypeptide binding]; other site 885276009361 dimer interface [polypeptide binding]; other site 885276009362 TPP binding site [chemical binding]; other site 885276009363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885276009364 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 885276009365 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 885276009366 agmatinase; Region: agmatinase; TIGR01230 885276009367 oligomer interface [polypeptide binding]; other site 885276009368 putative active site [active] 885276009369 Mn binding site [ion binding]; other site 885276009370 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 885276009371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 885276009372 dimer interface [polypeptide binding]; other site 885276009373 active site 885276009374 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885276009375 catalytic residues [active] 885276009376 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 885276009377 Virulence promoting factor; Region: YqgB; pfam11036 885276009378 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 885276009379 S-adenosylmethionine synthetase; Validated; Region: PRK05250 885276009380 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 885276009381 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 885276009382 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 885276009383 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 885276009384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009385 putative substrate translocation pore; other site 885276009386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009387 hypothetical protein; Provisional; Region: PRK04860 885276009388 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 885276009389 DNA-specific endonuclease I; Provisional; Region: PRK15137 885276009390 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 885276009391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 885276009392 RNA methyltransferase, RsmE family; Region: TIGR00046 885276009393 glutathione synthetase; Provisional; Region: PRK05246 885276009394 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 885276009395 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 885276009396 hypothetical protein; Validated; Region: PRK00228 885276009397 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 885276009398 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 885276009399 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 885276009400 Walker A motif; other site 885276009401 ATP binding site [chemical binding]; other site 885276009402 Walker B motif; other site 885276009403 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 885276009404 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885276009405 catalytic residue [active] 885276009406 YGGT family; Region: YGGT; pfam02325 885276009407 YGGT family; Region: YGGT; pfam02325 885276009408 hypothetical protein; Validated; Region: PRK05090 885276009409 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 885276009410 active site 885276009411 dimerization interface [polypeptide binding]; other site 885276009412 HemN family oxidoreductase; Provisional; Region: PRK05660 885276009413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276009414 FeS/SAM binding site; other site 885276009415 HemN C-terminal domain; Region: HemN_C; pfam06969 885276009416 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 885276009417 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 885276009418 homodimer interface [polypeptide binding]; other site 885276009419 active site 885276009420 hypothetical protein; Provisional; Region: PRK10626 885276009421 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 885276009422 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885276009423 hypothetical protein; Provisional; Region: PRK11702 885276009424 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 885276009425 adenine DNA glycosylase; Provisional; Region: PRK10880 885276009426 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 885276009427 minor groove reading motif; other site 885276009428 helix-hairpin-helix signature motif; other site 885276009429 substrate binding pocket [chemical binding]; other site 885276009430 active site 885276009431 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 885276009432 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 885276009433 DNA binding and oxoG recognition site [nucleotide binding] 885276009434 oxidative damage protection protein; Provisional; Region: PRK05408 885276009435 murein transglycosylase C; Provisional; Region: mltC; PRK11671 885276009436 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 885276009437 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885276009438 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885276009439 catalytic residue [active] 885276009440 nucleoside transporter; Region: 2A0110; TIGR00889 885276009441 ornithine decarboxylase; Provisional; Region: PRK13578 885276009442 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885276009443 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885276009444 homodimer interface [polypeptide binding]; other site 885276009445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276009446 catalytic residue [active] 885276009447 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885276009448 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 885276009449 integrase; Provisional; Region: PRK09692 885276009450 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276009451 active site 885276009452 Int/Topo IB signature motif; other site 885276009453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885276009454 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 885276009455 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885276009456 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885276009457 MarR family; Region: MarR_2; cl17246 885276009458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 885276009459 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 885276009460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 885276009461 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 885276009462 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 885276009463 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 885276009464 FaeA-like protein; Region: FaeA; pfam04703 885276009465 Transposase; Region: DDE_Tnp_ISL3; pfam01610 885276009466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 885276009467 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276009468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885276009469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276009470 Protein of unknown function, DUF417; Region: DUF417; pfam04224 885276009471 IS2 repressor TnpA; Reviewed; Region: PRK09413 885276009472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276009473 IS2 transposase TnpB; Reviewed; Region: PRK09409 885276009474 HTH-like domain; Region: HTH_21; pfam13276 885276009475 Integrase core domain; Region: rve; pfam00665 885276009476 Integrase core domain; Region: rve_3; pfam13683 885276009477 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 885276009478 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276009479 N-terminal plug; other site 885276009480 ligand-binding site [chemical binding]; other site 885276009481 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 885276009482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 885276009483 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 885276009484 L-lactate permease; Region: Lactate_perm; cl00701 885276009485 Integrase core domain; Region: rve; pfam00665 885276009486 Integrase core domain; Region: rve_2; pfam13333 885276009487 potential frameshift: common BLAST hit: gi|317052798|ref|YP_004119564.1| Integrase catalytic region 885276009488 HTH-like domain; Region: HTH_21; pfam13276 885276009489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276009490 Transposase; Region: HTH_Tnp_1; cl17663 885276009491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276009492 putative transposase OrfB; Reviewed; Region: PHA02517 885276009493 Integrase core domain; Region: rve; pfam00665 885276009494 Integrase core domain; Region: rve_3; pfam13683 885276009495 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 885276009496 Helix-turn-helix domain; Region: HTH_38; pfam13936 885276009497 Integrase core domain; Region: rve; pfam00665 885276009498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276009499 Transposase; Region: HTH_Tnp_1; pfam01527 885276009500 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885276009501 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 885276009502 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 885276009503 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276009504 Autotransporter beta-domain; Region: Autotransporter; pfam03797 885276009505 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885276009506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276009507 N-terminal plug; other site 885276009508 ligand-binding site [chemical binding]; other site 885276009509 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 885276009510 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276009511 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 885276009512 IucA / IucC family; Region: IucA_IucC; pfam04183 885276009513 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 885276009514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 885276009515 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 885276009516 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 885276009517 IucA / IucC family; Region: IucA_IucC; pfam04183 885276009518 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 885276009519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 885276009521 putative substrate translocation pore; other site 885276009522 IS2 transposase TnpB; Reviewed; Region: PRK09409 885276009523 HTH-like domain; Region: HTH_21; pfam13276 885276009524 Integrase core domain; Region: rve; pfam00665 885276009525 Integrase core domain; Region: rve_3; pfam13683 885276009526 IS2 repressor TnpA; Reviewed; Region: PRK09413 885276009527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276009528 Domain of unknown function (DUF303); Region: DUF303; pfam03629 885276009529 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 885276009530 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885276009531 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 885276009532 Kelch motif; Region: Kelch_1; pfam01344 885276009533 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 885276009534 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 885276009535 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885276009536 putative sialic acid transporter; Provisional; Region: PRK03893 885276009537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276009538 putative substrate translocation pore; other site 885276009539 N-acetylmannosamine kinase; Provisional; Region: PRK05082 885276009540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276009541 nucleotide binding site [chemical binding]; other site 885276009542 N-acetylneuraminate lyase; Provisional; Region: PRK04147 885276009543 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 885276009544 inhibitor site; inhibition site 885276009545 active site 885276009546 dimer interface [polypeptide binding]; other site 885276009547 catalytic residue [active] 885276009548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276009549 Transposase; Region: HTH_Tnp_1; pfam01527 885276009550 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 885276009551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885276009552 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 885276009553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885276009554 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 885276009555 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 885276009556 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 885276009557 homodimer interface [polypeptide binding]; other site 885276009558 putative GKAP docking site [polypeptide binding]; other site 885276009559 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 885276009560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 885276009561 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 885276009562 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 885276009563 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 885276009564 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885276009565 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 885276009566 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276009567 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 885276009568 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 885276009569 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 885276009570 Predicted GTPase [General function prediction only]; Region: COG3596 885276009571 YfjP GTPase; Region: YfjP; cd11383 885276009572 G1 box; other site 885276009573 GTP/Mg2+ binding site [chemical binding]; other site 885276009574 Switch I region; other site 885276009575 G2 box; other site 885276009576 Switch II region; other site 885276009577 G3 box; other site 885276009578 G4 box; other site 885276009579 G5 box; other site 885276009580 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885276009581 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885276009582 hypothetical protein; Provisional; Region: PRK09945 885276009583 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885276009584 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276009585 Autotransporter beta-domain; Region: Autotransporter; smart00869 885276009586 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 885276009587 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885276009588 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885276009589 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885276009590 MPN+ (JAMM) motif; other site 885276009591 Zinc-binding site [ion binding]; other site 885276009592 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885276009593 Methyltransferase domain; Region: Methyltransf_27; pfam13708 885276009594 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 885276009595 KpsF/GutQ family protein; Region: kpsF; TIGR00393 885276009596 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885276009597 putative active site [active] 885276009598 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 885276009599 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 885276009600 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 885276009601 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 885276009602 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 885276009603 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 885276009604 Ligand binding site; other site 885276009605 oligomer interface; other site 885276009606 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 885276009607 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 885276009608 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 885276009609 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 885276009610 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 885276009611 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 885276009612 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 885276009613 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 885276009614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885276009615 active site 885276009616 Integrase core domain; Region: rve; pfam00665 885276009617 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 885276009618 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 885276009619 Walker A/P-loop; other site 885276009620 ATP binding site [chemical binding]; other site 885276009621 Q-loop/lid; other site 885276009622 ABC transporter signature motif; other site 885276009623 Walker B; other site 885276009624 D-loop; other site 885276009625 H-loop/switch region; other site 885276009626 ABC-2 type transporter; Region: ABC2_membrane; cl17235 885276009627 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 885276009628 GspL-like protein; Provisional; Region: PRK09662 885276009629 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 885276009630 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885276009631 type II secretion system protein J; Region: gspJ; TIGR01711 885276009632 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 885276009633 type II secretion system protein I; Region: gspI; TIGR01707 885276009634 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 885276009635 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 885276009636 Type II transport protein GspH; Region: GspH; pfam12019 885276009637 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885276009638 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 885276009639 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 885276009640 type II secretion system protein F; Region: GspF; TIGR02120 885276009641 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885276009642 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885276009643 type II secretion system protein E; Region: type_II_gspE; TIGR02533 885276009644 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 885276009645 Walker A motif; other site 885276009646 ATP binding site [chemical binding]; other site 885276009647 Walker B motif; other site 885276009648 type II secretion system protein D; Region: type_II_gspD; TIGR02517 885276009649 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276009650 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276009651 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276009652 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 885276009653 putative type II secretion protein GspC; Provisional; Region: PRK09681 885276009654 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 885276009655 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885276009656 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 885276009657 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 885276009658 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 885276009659 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 885276009660 Peptidase M60-like family; Region: M60-like; pfam13402 885276009661 glycolate transporter; Provisional; Region: PRK09695 885276009662 L-lactate permease; Region: Lactate_perm; cl00701 885276009663 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 885276009664 active site 885276009665 hypothetical protein; Provisional; Region: PRK09732 885276009666 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 885276009667 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 885276009668 Cysteine-rich domain; Region: CCG; pfam02754 885276009669 Cysteine-rich domain; Region: CCG; pfam02754 885276009670 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 885276009671 FAD binding domain; Region: FAD_binding_4; pfam01565 885276009672 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 885276009673 FAD binding domain; Region: FAD_binding_4; pfam01565 885276009674 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 885276009675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276009676 DNA-binding site [nucleotide binding]; DNA binding site 885276009677 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276009678 acyl-CoA synthetase; Validated; Region: PRK09192 885276009679 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 885276009680 acyl-activating enzyme (AAE) consensus motif; other site 885276009681 active site 885276009682 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 885276009683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 885276009684 NAD(P) binding site [chemical binding]; other site 885276009685 active site 885276009686 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 885276009687 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 885276009688 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 885276009689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276009690 catalytic residue [active] 885276009691 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 885276009692 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885276009693 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885276009694 Predicted permeases [General function prediction only]; Region: COG0795 885276009695 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 885276009696 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 885276009697 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 885276009698 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 885276009699 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 885276009700 active site 885276009701 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 885276009702 TMP-binding site; other site 885276009703 ATP-binding site [chemical binding]; other site 885276009704 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 885276009705 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 885276009706 TMP-binding site; other site 885276009707 ATP-binding site [chemical binding]; other site 885276009708 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885276009709 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885276009710 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 885276009711 CHAP domain; Region: CHAP; pfam05257 885276009712 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 885276009713 putative S-transferase; Provisional; Region: PRK11752 885276009714 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 885276009715 C-terminal domain interface [polypeptide binding]; other site 885276009716 GSH binding site (G-site) [chemical binding]; other site 885276009717 dimer interface [polypeptide binding]; other site 885276009718 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 885276009719 dimer interface [polypeptide binding]; other site 885276009720 N-terminal domain interface [polypeptide binding]; other site 885276009721 active site 885276009722 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 885276009723 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 885276009724 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 885276009725 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 885276009726 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 885276009727 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 885276009728 putative substrate-binding site; other site 885276009729 nickel binding site [ion binding]; other site 885276009730 hydrogenase 2 large subunit; Provisional; Region: PRK10467 885276009731 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 885276009732 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 885276009733 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 885276009734 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 885276009735 4Fe-4S binding domain; Region: Fer4_6; pfam12837 885276009736 hydrogenase 2 small subunit; Provisional; Region: PRK10468 885276009737 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 885276009738 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 885276009739 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 885276009740 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 885276009741 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885276009742 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276009743 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276009744 active site 885276009745 catalytic tetrad [active] 885276009746 hypothetical protein; Provisional; Region: PRK05208 885276009747 oxidoreductase; Provisional; Region: PRK07985 885276009748 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 885276009749 NAD binding site [chemical binding]; other site 885276009750 metal binding site [ion binding]; metal-binding site 885276009751 active site 885276009752 biopolymer transport protein ExbD; Provisional; Region: PRK11267 885276009753 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 885276009754 biopolymer transport protein ExbB; Provisional; Region: PRK10414 885276009755 cystathionine beta-lyase; Provisional; Region: PRK08114 885276009756 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 885276009757 homodimer interface [polypeptide binding]; other site 885276009758 substrate-cofactor binding pocket; other site 885276009759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276009760 catalytic residue [active] 885276009761 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885276009762 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 885276009763 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 885276009764 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 885276009765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276009766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276009767 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 885276009768 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 885276009769 dimer interface [polypeptide binding]; other site 885276009770 active site 885276009771 metal binding site [ion binding]; metal-binding site 885276009772 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 885276009773 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 885276009774 active site 885276009775 catalytic tetrad [active] 885276009776 putative outer membrane lipoprotein; Provisional; Region: PRK09973 885276009777 hypothetical protein; Provisional; Region: PRK01254 885276009778 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 885276009779 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 885276009780 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885276009781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276009782 DNA-binding site [nucleotide binding]; DNA binding site 885276009783 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276009784 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 885276009785 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885276009786 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885276009787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276009788 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 885276009789 putative NAD(P) binding site [chemical binding]; other site 885276009790 catalytic Zn binding site [ion binding]; other site 885276009791 structural Zn binding site [ion binding]; other site 885276009792 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 885276009793 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 885276009794 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 885276009795 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 885276009796 DctM-like transporters; Region: DctM; pfam06808 885276009797 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 885276009798 FtsI repressor; Provisional; Region: PRK10883 885276009799 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 885276009800 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 885276009801 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 885276009802 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 885276009803 putative acyl-acceptor binding pocket; other site 885276009804 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 885276009805 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 885276009806 CAP-like domain; other site 885276009807 active site 885276009808 primary dimer interface [polypeptide binding]; other site 885276009809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 885276009810 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 885276009811 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 885276009812 peptide binding site [polypeptide binding]; other site 885276009813 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 885276009814 TIGR00156 family protein; Region: TIGR00156 885276009815 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 885276009816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276009817 active site 885276009818 phosphorylation site [posttranslational modification] 885276009819 intermolecular recognition site; other site 885276009820 dimerization interface [polypeptide binding]; other site 885276009821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276009822 DNA binding site [nucleotide binding] 885276009823 sensor protein QseC; Provisional; Region: PRK10337 885276009824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276009825 dimer interface [polypeptide binding]; other site 885276009826 phosphorylation site [posttranslational modification] 885276009827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276009828 ATP binding site [chemical binding]; other site 885276009829 Mg2+ binding site [ion binding]; other site 885276009830 G-X-G motif; other site 885276009831 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 885276009832 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 885276009833 Uncharacterized conserved protein [Function unknown]; Region: COG1359 885276009834 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 885276009835 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885276009836 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 885276009837 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 885276009838 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 885276009839 siderophore binding site; other site 885276009840 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 885276009841 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276009842 ABC-ATPase subunit interface; other site 885276009843 dimer interface [polypeptide binding]; other site 885276009844 putative PBP binding regions; other site 885276009845 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885276009846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276009847 dimer interface [polypeptide binding]; other site 885276009848 putative PBP binding regions; other site 885276009849 ABC-ATPase subunit interface; other site 885276009850 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 885276009851 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276009852 Walker A/P-loop; other site 885276009853 ATP binding site [chemical binding]; other site 885276009854 Q-loop/lid; other site 885276009855 ABC transporter signature motif; other site 885276009856 Walker B; other site 885276009857 D-loop; other site 885276009858 H-loop/switch region; other site 885276009859 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 885276009860 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276009861 N-terminal plug; other site 885276009862 ligand-binding site [chemical binding]; other site 885276009863 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 885276009864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276009865 ATP binding site [chemical binding]; other site 885276009866 Mg2+ binding site [ion binding]; other site 885276009867 G-X-G motif; other site 885276009868 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 885276009869 anchoring element; other site 885276009870 dimer interface [polypeptide binding]; other site 885276009871 ATP binding site [chemical binding]; other site 885276009872 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 885276009873 active site 885276009874 metal binding site [ion binding]; metal-binding site 885276009875 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 885276009876 esterase YqiA; Provisional; Region: PRK11071 885276009877 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 885276009878 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 885276009879 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 885276009880 active site 885276009881 metal binding site [ion binding]; metal-binding site 885276009882 hexamer interface [polypeptide binding]; other site 885276009883 putative dehydrogenase; Provisional; Region: PRK11039 885276009884 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 885276009885 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 885276009886 dimer interface [polypeptide binding]; other site 885276009887 ADP-ribose binding site [chemical binding]; other site 885276009888 active site 885276009889 nudix motif; other site 885276009890 metal binding site [ion binding]; metal-binding site 885276009891 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 885276009892 hypothetical protein; Provisional; Region: PRK11653 885276009893 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 885276009894 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 885276009895 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 885276009896 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 885276009897 catalytic residues [active] 885276009898 hinge region; other site 885276009899 alpha helical domain; other site 885276009900 putative disulfide oxidoreductase; Provisional; Region: PRK04307 885276009901 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 885276009902 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 885276009903 putative active site [active] 885276009904 metal binding site [ion binding]; metal-binding site 885276009905 zinc transporter ZupT; Provisional; Region: PRK04201 885276009906 ZIP Zinc transporter; Region: Zip; pfam02535 885276009907 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 885276009908 putative fimbrial protein; Provisional; Region: PRK09733 885276009909 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 885276009910 PapC N-terminal domain; Region: PapC_N; pfam13954 885276009911 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276009912 PapC C-terminal domain; Region: PapC_C; pfam13953 885276009913 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 885276009914 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276009915 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276009916 Fimbrial protein; Region: Fimbrial; pfam00419 885276009917 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 885276009918 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 885276009919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 885276009920 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 885276009921 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 885276009922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 885276009923 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 885276009924 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 885276009925 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 885276009926 putative ribose interaction site [chemical binding]; other site 885276009927 putative ADP binding site [chemical binding]; other site 885276009928 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 885276009929 active site 885276009930 nucleotide binding site [chemical binding]; other site 885276009931 HIGH motif; other site 885276009932 KMSKS motif; other site 885276009933 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 885276009934 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 885276009935 metal binding triad; other site 885276009936 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 885276009937 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 885276009938 metal binding triad; other site 885276009939 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 885276009940 Uncharacterized conserved protein [Function unknown]; Region: COG3025 885276009941 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 885276009942 putative active site [active] 885276009943 putative metal binding residues [ion binding]; other site 885276009944 signature motif; other site 885276009945 putative triphosphate binding site [ion binding]; other site 885276009946 CHAD domain; Region: CHAD; pfam05235 885276009947 Transposase IS200 like; Region: Y1_Tnp; pfam01797 885276009948 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 885276009949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 885276009950 Probable transposase; Region: OrfB_IS605; pfam01385 885276009951 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 885276009952 SH3 domain-containing protein; Provisional; Region: PRK10884 885276009953 Bacterial SH3 domain homologues; Region: SH3b; smart00287 885276009954 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 885276009955 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 885276009956 active site 885276009957 NTP binding site [chemical binding]; other site 885276009958 metal binding triad [ion binding]; metal-binding site 885276009959 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 885276009960 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885276009961 Zn2+ binding site [ion binding]; other site 885276009962 Mg2+ binding site [ion binding]; other site 885276009963 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 885276009964 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 885276009965 homooctamer interface [polypeptide binding]; other site 885276009966 active site 885276009967 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 885276009968 transcriptional activator TtdR; Provisional; Region: PRK09801 885276009969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276009970 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 885276009971 putative effector binding pocket; other site 885276009972 putative dimerization interface [polypeptide binding]; other site 885276009973 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 885276009974 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 885276009975 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276009976 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 885276009977 transmembrane helices; other site 885276009978 UGMP family protein; Validated; Region: PRK09604 885276009979 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 885276009980 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 885276009981 DNA primase; Validated; Region: dnaG; PRK05667 885276009982 CHC2 zinc finger; Region: zf-CHC2; pfam01807 885276009983 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 885276009984 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 885276009985 active site 885276009986 metal binding site [ion binding]; metal-binding site 885276009987 interdomain interaction site; other site 885276009988 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 885276009989 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 885276009990 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 885276009991 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 885276009992 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 885276009993 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 885276009994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885276009995 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 885276009996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885276009997 DNA binding residues [nucleotide binding] 885276009998 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 885276009999 active site 885276010000 SUMO-1 interface [polypeptide binding]; other site 885276010001 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 885276010002 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 885276010003 FAD binding pocket [chemical binding]; other site 885276010004 FAD binding motif [chemical binding]; other site 885276010005 phosphate binding motif [ion binding]; other site 885276010006 NAD binding pocket [chemical binding]; other site 885276010007 Predicted transcriptional regulators [Transcription]; Region: COG1695 885276010008 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 885276010009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276010010 PAS fold; Region: PAS_3; pfam08447 885276010011 putative active site [active] 885276010012 heme pocket [chemical binding]; other site 885276010013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 885276010014 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 885276010015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885276010016 dimer interface [polypeptide binding]; other site 885276010017 putative CheW interface [polypeptide binding]; other site 885276010018 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 885276010019 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885276010020 inhibitor-cofactor binding pocket; inhibition site 885276010021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276010022 catalytic residue [active] 885276010023 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 885276010024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276010025 DNA binding site [nucleotide binding] 885276010026 domain linker motif; other site 885276010027 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 885276010028 putative dimerization interface [polypeptide binding]; other site 885276010029 putative ligand binding site [chemical binding]; other site 885276010030 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 885276010031 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 885276010032 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 885276010033 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 885276010034 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 885276010035 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 885276010036 inner membrane transporter YjeM; Provisional; Region: PRK15238 885276010037 alpha-glucosidase; Provisional; Region: PRK10137 885276010038 Protein of unknown function, DUF608; Region: DUF608; pfam04685 885276010039 Trehalase; Region: Trehalase; cl17346 885276010040 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 885276010041 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 885276010042 active site 885276010043 FMN binding site [chemical binding]; other site 885276010044 2,4-decadienoyl-CoA binding site; other site 885276010045 catalytic residue [active] 885276010046 4Fe-4S cluster binding site [ion binding]; other site 885276010047 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 885276010048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276010049 non-specific DNA binding site [nucleotide binding]; other site 885276010050 salt bridge; other site 885276010051 sequence-specific DNA binding site [nucleotide binding]; other site 885276010052 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 885276010053 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 885276010054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276010055 S-adenosylmethionine binding site [chemical binding]; other site 885276010056 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 885276010057 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 885276010058 putative active site [active] 885276010059 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 885276010060 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885276010061 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 885276010062 serine/threonine transporter SstT; Provisional; Region: PRK13628 885276010063 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885276010064 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 885276010065 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 885276010066 galactarate dehydratase; Region: galactar-dH20; TIGR03248 885276010067 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 885276010068 Glucuronate isomerase; Region: UxaC; pfam02614 885276010069 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 885276010070 D-galactonate transporter; Region: 2A0114; TIGR00893 885276010071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276010072 putative substrate translocation pore; other site 885276010073 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 885276010074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276010075 DNA-binding site [nucleotide binding]; DNA binding site 885276010076 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276010077 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 885276010078 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 885276010079 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 885276010080 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 885276010081 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 885276010082 Predicted membrane protein [Function unknown]; Region: COG5393 885276010083 YqjK-like protein; Region: YqjK; pfam13997 885276010084 Predicted membrane protein [Function unknown]; Region: COG2259 885276010085 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 885276010086 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 885276010087 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 885276010088 putative dimer interface [polypeptide binding]; other site 885276010089 N-terminal domain interface [polypeptide binding]; other site 885276010090 putative substrate binding pocket (H-site) [chemical binding]; other site 885276010091 Predicted membrane protein [Function unknown]; Region: COG3152 885276010092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276010093 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885276010094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276010095 dimerization interface [polypeptide binding]; other site 885276010096 Pirin-related protein [General function prediction only]; Region: COG1741 885276010097 Pirin; Region: Pirin; pfam02678 885276010098 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 885276010099 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885276010100 serine transporter; Region: stp; TIGR00814 885276010101 L-serine dehydratase TdcG; Provisional; Region: PRK15040 885276010102 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 885276010103 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 885276010104 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 885276010105 homotrimer interaction site [polypeptide binding]; other site 885276010106 putative active site [active] 885276010107 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 885276010108 Pyruvate formate lyase 1; Region: PFL1; cd01678 885276010109 coenzyme A binding site [chemical binding]; other site 885276010110 active site 885276010111 catalytic residues [active] 885276010112 glycine loop; other site 885276010113 propionate/acetate kinase; Provisional; Region: PRK12379 885276010114 Acetokinase family; Region: Acetate_kinase; cl17229 885276010115 threonine/serine transporter TdcC; Provisional; Region: PRK13629 885276010116 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885276010117 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 885276010118 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 885276010119 tetramer interface [polypeptide binding]; other site 885276010120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276010121 catalytic residue [active] 885276010122 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 885276010123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276010124 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 885276010125 putative substrate binding pocket [chemical binding]; other site 885276010126 putative dimerization interface [polypeptide binding]; other site 885276010127 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 885276010128 glycerate kinase I; Provisional; Region: PRK10342 885276010129 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 885276010130 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885276010131 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 885276010132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276010133 D-galactonate transporter; Region: 2A0114; TIGR00893 885276010134 putative substrate translocation pore; other site 885276010135 galactarate dehydratase; Region: galactar-dH20; TIGR03248 885276010136 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 885276010137 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 885276010138 putative regulator PrlF; Provisional; Region: PRK09974 885276010139 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 885276010140 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 885276010141 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 885276010142 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276010143 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276010144 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 885276010145 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885276010146 active site 885276010147 phosphorylation site [posttranslational modification] 885276010148 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 885276010149 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 885276010150 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885276010151 active pocket/dimerization site; other site 885276010152 active site 885276010153 phosphorylation site [posttranslational modification] 885276010154 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 885276010155 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 885276010156 active site 885276010157 dimer interface [polypeptide binding]; other site 885276010158 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 885276010159 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 885276010160 dimer interface [polypeptide binding]; other site 885276010161 active site 885276010162 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 885276010163 putative active site [active] 885276010164 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 885276010165 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885276010166 active site 885276010167 intersubunit interface [polypeptide binding]; other site 885276010168 zinc binding site [ion binding]; other site 885276010169 Na+ binding site [ion binding]; other site 885276010170 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885276010171 active site 885276010172 phosphorylation site [posttranslational modification] 885276010173 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 885276010174 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 885276010175 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 885276010176 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 885276010177 active site 885276010178 trimer interface [polypeptide binding]; other site 885276010179 allosteric site; other site 885276010180 active site lid [active] 885276010181 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 885276010182 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 885276010183 putative SAM binding site [chemical binding]; other site 885276010184 putative homodimer interface [polypeptide binding]; other site 885276010185 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 885276010186 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 885276010187 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 885276010188 putative ligand binding site [chemical binding]; other site 885276010189 TIGR00252 family protein; Region: TIGR00252 885276010190 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 885276010191 dimer interface [polypeptide binding]; other site 885276010192 active site 885276010193 outer membrane lipoprotein; Provisional; Region: PRK11023 885276010194 BON domain; Region: BON; pfam04972 885276010195 BON domain; Region: BON; pfam04972 885276010196 Predicted permease; Region: DUF318; pfam03773 885276010197 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 885276010198 NADH(P)-binding; Region: NAD_binding_10; pfam13460 885276010199 NAD binding site [chemical binding]; other site 885276010200 active site 885276010201 hypothetical protein; Provisional; Region: PRK03467 885276010202 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 885276010203 GIY-YIG motif/motif A; other site 885276010204 putative active site [active] 885276010205 putative metal binding site [ion binding]; other site 885276010206 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 885276010207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276010208 Coenzyme A binding pocket [chemical binding]; other site 885276010209 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 885276010210 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 885276010211 Peptidase family U32; Region: Peptidase_U32; pfam01136 885276010212 putative protease; Provisional; Region: PRK15447 885276010213 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 885276010214 hypothetical protein; Provisional; Region: PRK10508 885276010215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 885276010216 tryptophan permease; Provisional; Region: PRK10483 885276010217 aromatic amino acid transport protein; Region: araaP; TIGR00837 885276010218 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 885276010219 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885276010220 ATP binding site [chemical binding]; other site 885276010221 Mg++ binding site [ion binding]; other site 885276010222 motif III; other site 885276010223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276010224 nucleotide binding region [chemical binding]; other site 885276010225 ATP-binding site [chemical binding]; other site 885276010226 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 885276010227 putative RNA binding site [nucleotide binding]; other site 885276010228 lipoprotein NlpI; Provisional; Region: PRK11189 885276010229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276010230 binding surface 885276010231 TPR motif; other site 885276010232 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 885276010233 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 885276010234 RNase E interface [polypeptide binding]; other site 885276010235 trimer interface [polypeptide binding]; other site 885276010236 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 885276010237 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 885276010238 RNase E interface [polypeptide binding]; other site 885276010239 trimer interface [polypeptide binding]; other site 885276010240 active site 885276010241 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 885276010242 putative nucleic acid binding region [nucleotide binding]; other site 885276010243 G-X-X-G motif; other site 885276010244 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 885276010245 RNA binding site [nucleotide binding]; other site 885276010246 domain interface; other site 885276010247 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 885276010248 16S/18S rRNA binding site [nucleotide binding]; other site 885276010249 S13e-L30e interaction site [polypeptide binding]; other site 885276010250 25S rRNA binding site [nucleotide binding]; other site 885276010251 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 885276010252 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 885276010253 RNA binding site [nucleotide binding]; other site 885276010254 active site 885276010255 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 885276010256 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 885276010257 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 885276010258 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 885276010259 translation initiation factor IF-2; Region: IF-2; TIGR00487 885276010260 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 885276010261 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 885276010262 G1 box; other site 885276010263 putative GEF interaction site [polypeptide binding]; other site 885276010264 GTP/Mg2+ binding site [chemical binding]; other site 885276010265 Switch I region; other site 885276010266 G2 box; other site 885276010267 G3 box; other site 885276010268 Switch II region; other site 885276010269 G4 box; other site 885276010270 G5 box; other site 885276010271 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 885276010272 Translation-initiation factor 2; Region: IF-2; pfam11987 885276010273 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 885276010274 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 885276010275 NusA N-terminal domain; Region: NusA_N; pfam08529 885276010276 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 885276010277 RNA binding site [nucleotide binding]; other site 885276010278 homodimer interface [polypeptide binding]; other site 885276010279 NusA-like KH domain; Region: KH_5; pfam13184 885276010280 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 885276010281 G-X-X-G motif; other site 885276010282 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 885276010283 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 885276010284 ribosome maturation protein RimP; Reviewed; Region: PRK00092 885276010285 Sm and related proteins; Region: Sm_like; cl00259 885276010286 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 885276010287 putative oligomer interface [polypeptide binding]; other site 885276010288 putative RNA binding site [nucleotide binding]; other site 885276010289 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 885276010290 ANP binding site [chemical binding]; other site 885276010291 Substrate Binding Site II [chemical binding]; other site 885276010292 Substrate Binding Site I [chemical binding]; other site 885276010293 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 885276010294 Sulfatase; Region: Sulfatase; pfam00884 885276010295 Preprotein translocase SecG subunit; Region: SecG; pfam03840 885276010296 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 885276010297 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 885276010298 active site 885276010299 substrate binding site [chemical binding]; other site 885276010300 metal binding site [ion binding]; metal-binding site 885276010301 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 885276010302 dihydropteroate synthase; Region: DHPS; TIGR01496 885276010303 substrate binding pocket [chemical binding]; other site 885276010304 dimer interface [polypeptide binding]; other site 885276010305 inhibitor binding site; inhibition site 885276010306 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 885276010307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276010308 Walker A motif; other site 885276010309 ATP binding site [chemical binding]; other site 885276010310 Walker B motif; other site 885276010311 arginine finger; other site 885276010312 Peptidase family M41; Region: Peptidase_M41; pfam01434 885276010313 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 885276010314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276010315 S-adenosylmethionine binding site [chemical binding]; other site 885276010316 RNA-binding protein YhbY; Provisional; Region: PRK10343 885276010317 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 885276010318 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 885276010319 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 885276010320 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 885276010321 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 885276010322 GTPase CgtA; Reviewed; Region: obgE; PRK12298 885276010323 GTP1/OBG; Region: GTP1_OBG; pfam01018 885276010324 Obg GTPase; Region: Obg; cd01898 885276010325 G1 box; other site 885276010326 GTP/Mg2+ binding site [chemical binding]; other site 885276010327 Switch I region; other site 885276010328 G2 box; other site 885276010329 G3 box; other site 885276010330 Switch II region; other site 885276010331 G4 box; other site 885276010332 G5 box; other site 885276010333 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 885276010334 EamA-like transporter family; Region: EamA; pfam00892 885276010335 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 885276010336 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 885276010337 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 885276010338 substrate binding pocket [chemical binding]; other site 885276010339 chain length determination region; other site 885276010340 substrate-Mg2+ binding site; other site 885276010341 catalytic residues [active] 885276010342 aspartate-rich region 1; other site 885276010343 active site lid residues [active] 885276010344 aspartate-rich region 2; other site 885276010345 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 885276010346 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 885276010347 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 885276010348 hinge; other site 885276010349 active site 885276010350 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 885276010351 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 885276010352 anti sigma factor interaction site; other site 885276010353 regulatory phosphorylation site [posttranslational modification]; other site 885276010354 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 885276010355 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 885276010356 mce related protein; Region: MCE; pfam02470 885276010357 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 885276010358 conserved hypothetical integral membrane protein; Region: TIGR00056 885276010359 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 885276010360 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 885276010361 Walker A/P-loop; other site 885276010362 ATP binding site [chemical binding]; other site 885276010363 Q-loop/lid; other site 885276010364 ABC transporter signature motif; other site 885276010365 Walker B; other site 885276010366 D-loop; other site 885276010367 H-loop/switch region; other site 885276010368 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 885276010369 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 885276010370 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 885276010371 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 885276010372 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 885276010373 putative active site [active] 885276010374 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 885276010375 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 885276010376 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 885276010377 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 885276010378 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 885276010379 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 885276010380 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 885276010381 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 885276010382 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 885276010383 Walker A/P-loop; other site 885276010384 ATP binding site [chemical binding]; other site 885276010385 Q-loop/lid; other site 885276010386 ABC transporter signature motif; other site 885276010387 Walker B; other site 885276010388 D-loop; other site 885276010389 H-loop/switch region; other site 885276010390 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 885276010391 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 885276010392 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 885276010393 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 885276010394 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 885276010395 30S subunit binding site; other site 885276010396 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276010397 active site 885276010398 phosphorylation site [posttranslational modification] 885276010399 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 885276010400 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276010401 dimerization domain swap beta strand [polypeptide binding]; other site 885276010402 regulatory protein interface [polypeptide binding]; other site 885276010403 active site 885276010404 regulatory phosphorylation site [posttranslational modification]; other site 885276010405 hypothetical protein; Provisional; Region: PRK10345 885276010406 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 885276010407 Transglycosylase; Region: Transgly; cl17702 885276010408 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 885276010409 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 885276010410 conserved cys residue [active] 885276010411 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 885276010412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276010413 putative active site [active] 885276010414 heme pocket [chemical binding]; other site 885276010415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276010416 dimer interface [polypeptide binding]; other site 885276010417 phosphorylation site [posttranslational modification] 885276010418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276010419 ATP binding site [chemical binding]; other site 885276010420 Mg2+ binding site [ion binding]; other site 885276010421 G-X-G motif; other site 885276010422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276010423 active site 885276010424 phosphorylation site [posttranslational modification] 885276010425 intermolecular recognition site; other site 885276010426 dimerization interface [polypeptide binding]; other site 885276010427 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 885276010428 putative binding surface; other site 885276010429 active site 885276010430 radical SAM protein, TIGR01212 family; Region: TIGR01212 885276010431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276010432 FeS/SAM binding site; other site 885276010433 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 885276010434 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 885276010435 active site 885276010436 dimer interface [polypeptide binding]; other site 885276010437 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 885276010438 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 885276010439 active site 885276010440 FMN binding site [chemical binding]; other site 885276010441 substrate binding site [chemical binding]; other site 885276010442 3Fe-4S cluster binding site [ion binding]; other site 885276010443 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 885276010444 domain interface; other site 885276010445 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 885276010446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276010447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276010448 Domain of unknown function (DUF386); Region: DUF386; cl01047 885276010449 N-acetylmannosamine kinase; Provisional; Region: PRK05082 885276010450 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276010451 nucleotide binding site [chemical binding]; other site 885276010452 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885276010453 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 885276010454 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 885276010455 putative active site cavity [active] 885276010456 putative sialic acid transporter; Provisional; Region: PRK03893 885276010457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276010458 putative substrate translocation pore; other site 885276010459 N-acetylneuraminate lyase; Region: nanA; TIGR00683 885276010460 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 885276010461 inhibitor site; inhibition site 885276010462 active site 885276010463 dimer interface [polypeptide binding]; other site 885276010464 catalytic residue [active] 885276010465 transcriptional regulator NanR; Provisional; Region: PRK03837 885276010466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276010467 DNA-binding site [nucleotide binding]; DNA binding site 885276010468 FCD domain; Region: FCD; pfam07729 885276010469 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 885276010470 stringent starvation protein A; Provisional; Region: sspA; PRK09481 885276010471 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 885276010472 C-terminal domain interface [polypeptide binding]; other site 885276010473 putative GSH binding site (G-site) [chemical binding]; other site 885276010474 dimer interface [polypeptide binding]; other site 885276010475 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 885276010476 dimer interface [polypeptide binding]; other site 885276010477 N-terminal domain interface [polypeptide binding]; other site 885276010478 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 885276010479 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 885276010480 23S rRNA interface [nucleotide binding]; other site 885276010481 L3 interface [polypeptide binding]; other site 885276010482 Predicted ATPase [General function prediction only]; Region: COG1485 885276010483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 885276010484 hypothetical protein; Provisional; Region: PRK11677 885276010485 serine endoprotease; Provisional; Region: PRK10139 885276010486 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 885276010487 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885276010488 protein binding site [polypeptide binding]; other site 885276010489 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885276010490 serine endoprotease; Provisional; Region: PRK10898 885276010491 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 885276010492 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 885276010493 malate dehydrogenase; Provisional; Region: PRK05086 885276010494 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 885276010495 NAD binding site [chemical binding]; other site 885276010496 dimerization interface [polypeptide binding]; other site 885276010497 Substrate binding site [chemical binding]; other site 885276010498 arginine repressor; Provisional; Region: PRK05066 885276010499 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 885276010500 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 885276010501 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276010502 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 885276010503 RNAase interaction site [polypeptide binding]; other site 885276010504 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 885276010505 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885276010506 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 885276010507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276010508 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276010509 efflux system membrane protein; Provisional; Region: PRK11594 885276010510 transcriptional regulator; Provisional; Region: PRK10632 885276010511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276010512 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 885276010513 putative effector binding pocket; other site 885276010514 dimerization interface [polypeptide binding]; other site 885276010515 protease TldD; Provisional; Region: tldD; PRK10735 885276010516 hypothetical protein; Provisional; Region: PRK10899 885276010517 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 885276010518 ribonuclease G; Provisional; Region: PRK11712 885276010519 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 885276010520 homodimer interface [polypeptide binding]; other site 885276010521 oligonucleotide binding site [chemical binding]; other site 885276010522 Maf-like protein; Region: Maf; pfam02545 885276010523 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 885276010524 active site 885276010525 dimer interface [polypeptide binding]; other site 885276010526 rod shape-determining protein MreD; Provisional; Region: PRK11060 885276010527 rod shape-determining protein MreC; Region: mreC; TIGR00219 885276010528 rod shape-determining protein MreC; Region: MreC; pfam04085 885276010529 rod shape-determining protein MreB; Provisional; Region: PRK13927 885276010530 MreB and similar proteins; Region: MreB_like; cd10225 885276010531 nucleotide binding site [chemical binding]; other site 885276010532 Mg binding site [ion binding]; other site 885276010533 putative protofilament interaction site [polypeptide binding]; other site 885276010534 RodZ interaction site [polypeptide binding]; other site 885276010535 regulatory protein CsrD; Provisional; Region: PRK11059 885276010536 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276010537 metal binding site [ion binding]; metal-binding site 885276010538 active site 885276010539 I-site; other site 885276010540 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276010541 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 885276010542 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 885276010543 NADP binding site [chemical binding]; other site 885276010544 dimer interface [polypeptide binding]; other site 885276010545 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 885276010546 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 885276010547 carboxyltransferase (CT) interaction site; other site 885276010548 biotinylation site [posttranslational modification]; other site 885276010549 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 885276010550 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 885276010551 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 885276010552 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 885276010553 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 885276010554 active site 885276010555 catalytic residues [active] 885276010556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276010557 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885276010558 substrate binding site [chemical binding]; other site 885276010559 ATP binding site [chemical binding]; other site 885276010560 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276010561 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276010562 TM-ABC transporter signature motif; other site 885276010563 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 885276010564 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276010565 Walker A/P-loop; other site 885276010566 ATP binding site [chemical binding]; other site 885276010567 Q-loop/lid; other site 885276010568 ABC transporter signature motif; other site 885276010569 Walker B; other site 885276010570 D-loop; other site 885276010571 H-loop/switch region; other site 885276010572 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276010573 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 885276010574 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 885276010575 putative ligand binding site [chemical binding]; other site 885276010576 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885276010577 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 885276010578 intersubunit interface [polypeptide binding]; other site 885276010579 active site 885276010580 zinc binding site [ion binding]; other site 885276010581 Na+ binding site [ion binding]; other site 885276010582 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276010583 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 885276010584 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276010585 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276010586 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885276010587 substrate binding site [chemical binding]; other site 885276010588 ATP binding site [chemical binding]; other site 885276010589 hypothetical protein; Provisional; Region: PRK10633 885276010590 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 885276010591 Na binding site [ion binding]; other site 885276010592 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 885276010593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 885276010594 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 885276010595 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 885276010596 FMN binding site [chemical binding]; other site 885276010597 active site 885276010598 catalytic residues [active] 885276010599 substrate binding site [chemical binding]; other site 885276010600 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 885276010601 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 885276010602 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 885276010603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276010604 DNA methylase; Region: N6_N4_Mtase; pfam01555 885276010605 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 885276010606 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 885276010607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276010608 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 885276010609 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 885276010610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276010611 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276010612 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 885276010613 Protein export membrane protein; Region: SecD_SecF; cl14618 885276010614 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 885276010615 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 885276010616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276010617 substrate binding pocket [chemical binding]; other site 885276010618 membrane-bound complex binding site; other site 885276010619 hinge residues; other site 885276010620 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 885276010621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276010622 conserved gate region; other site 885276010623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276010624 dimer interface [polypeptide binding]; other site 885276010625 conserved gate region; other site 885276010626 putative PBP binding loops; other site 885276010627 ABC-ATPase subunit interface; other site 885276010628 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 885276010629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276010630 dimer interface [polypeptide binding]; other site 885276010631 conserved gate region; other site 885276010632 putative PBP binding loops; other site 885276010633 ABC-ATPase subunit interface; other site 885276010634 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 885276010635 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 885276010636 Walker A/P-loop; other site 885276010637 ATP binding site [chemical binding]; other site 885276010638 Q-loop/lid; other site 885276010639 ABC transporter signature motif; other site 885276010640 Walker B; other site 885276010641 D-loop; other site 885276010642 H-loop/switch region; other site 885276010643 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 885276010644 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 885276010645 trimer interface [polypeptide binding]; other site 885276010646 putative metal binding site [ion binding]; other site 885276010647 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 885276010648 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 885276010649 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 885276010650 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 885276010651 shikimate binding site; other site 885276010652 NAD(P) binding site [chemical binding]; other site 885276010653 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 885276010654 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885276010655 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 885276010656 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885276010657 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 885276010658 hypothetical protein; Validated; Region: PRK03430 885276010659 hypothetical protein; Provisional; Region: PRK10736 885276010660 DNA protecting protein DprA; Region: dprA; TIGR00732 885276010661 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 885276010662 active site 885276010663 catalytic residues [active] 885276010664 metal binding site [ion binding]; metal-binding site 885276010665 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 885276010666 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 885276010667 putative active site [active] 885276010668 substrate binding site [chemical binding]; other site 885276010669 putative cosubstrate binding site; other site 885276010670 catalytic site [active] 885276010671 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 885276010672 substrate binding site [chemical binding]; other site 885276010673 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 885276010674 putative RNA binding site [nucleotide binding]; other site 885276010675 16S rRNA methyltransferase B; Provisional; Region: PRK10901 885276010676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276010677 S-adenosylmethionine binding site [chemical binding]; other site 885276010678 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 885276010679 TrkA-N domain; Region: TrkA_N; pfam02254 885276010680 TrkA-C domain; Region: TrkA_C; pfam02080 885276010681 TrkA-N domain; Region: TrkA_N; pfam02254 885276010682 TrkA-C domain; Region: TrkA_C; pfam02080 885276010683 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 885276010684 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 885276010685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 885276010686 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 885276010687 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 885276010688 DNA binding residues [nucleotide binding] 885276010689 dimer interface [polypeptide binding]; other site 885276010690 metal binding site [ion binding]; metal-binding site 885276010691 hypothetical protein; Provisional; Region: PRK10203 885276010692 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 885276010693 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 885276010694 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 885276010695 alphaNTD homodimer interface [polypeptide binding]; other site 885276010696 alphaNTD - beta interaction site [polypeptide binding]; other site 885276010697 alphaNTD - beta' interaction site [polypeptide binding]; other site 885276010698 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 885276010699 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 885276010700 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 885276010701 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276010702 RNA binding surface [nucleotide binding]; other site 885276010703 30S ribosomal protein S11; Validated; Region: PRK05309 885276010704 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 885276010705 30S ribosomal protein S13; Region: bact_S13; TIGR03631 885276010706 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 885276010707 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 885276010708 SecY translocase; Region: SecY; pfam00344 885276010709 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 885276010710 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 885276010711 23S rRNA binding site [nucleotide binding]; other site 885276010712 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 885276010713 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 885276010714 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 885276010715 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 885276010716 23S rRNA interface [nucleotide binding]; other site 885276010717 5S rRNA interface [nucleotide binding]; other site 885276010718 L27 interface [polypeptide binding]; other site 885276010719 L5 interface [polypeptide binding]; other site 885276010720 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 885276010721 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 885276010722 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 885276010723 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 885276010724 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 885276010725 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 885276010726 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 885276010727 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 885276010728 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 885276010729 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 885276010730 RNA binding site [nucleotide binding]; other site 885276010731 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 885276010732 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 885276010733 23S rRNA interface [nucleotide binding]; other site 885276010734 putative translocon interaction site; other site 885276010735 signal recognition particle (SRP54) interaction site; other site 885276010736 L23 interface [polypeptide binding]; other site 885276010737 trigger factor interaction site; other site 885276010738 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 885276010739 23S rRNA interface [nucleotide binding]; other site 885276010740 5S rRNA interface [nucleotide binding]; other site 885276010741 putative antibiotic binding site [chemical binding]; other site 885276010742 L25 interface [polypeptide binding]; other site 885276010743 L27 interface [polypeptide binding]; other site 885276010744 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 885276010745 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 885276010746 G-X-X-G motif; other site 885276010747 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 885276010748 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 885276010749 protein-rRNA interface [nucleotide binding]; other site 885276010750 putative translocon binding site; other site 885276010751 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 885276010752 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 885276010753 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 885276010754 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 885276010755 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 885276010756 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 885276010757 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 885276010758 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 885276010759 protein secretion protein GspB; Provisional; Region: PRK09697 885276010760 AAA domain; Region: AAA_22; pfam13401 885276010761 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 885276010762 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 885276010763 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 885276010764 type II secretion system protein D; Region: type_II_gspD; TIGR02517 885276010765 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276010766 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276010767 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276010768 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 885276010769 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 885276010770 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 885276010771 Walker A motif; other site 885276010772 ATP binding site [chemical binding]; other site 885276010773 Walker B motif; other site 885276010774 type II secretion system protein F; Region: GspF; TIGR02120 885276010775 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885276010776 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 885276010777 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885276010778 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 885276010779 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 885276010780 Type II transport protein GspH; Region: GspH; pfam12019 885276010781 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 885276010782 type II secretion system protein I; Region: gspI; TIGR01707 885276010783 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 885276010784 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 885276010785 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 885276010786 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 885276010787 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 885276010788 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 885276010789 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 885276010790 GspL periplasmic domain; Region: GspL_C; pfam12693 885276010791 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 885276010792 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 885276010793 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 885276010794 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 885276010795 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 885276010796 heme binding site [chemical binding]; other site 885276010797 ferroxidase pore; other site 885276010798 ferroxidase diiron center [ion binding]; other site 885276010799 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 885276010800 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 885276010801 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 885276010802 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 885276010803 aromatic chitin/cellulose binding site residues [chemical binding]; other site 885276010804 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 885276010805 active site 885276010806 elongation factor Tu; Reviewed; Region: PRK00049 885276010807 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 885276010808 G1 box; other site 885276010809 GEF interaction site [polypeptide binding]; other site 885276010810 GTP/Mg2+ binding site [chemical binding]; other site 885276010811 Switch I region; other site 885276010812 G2 box; other site 885276010813 G3 box; other site 885276010814 Switch II region; other site 885276010815 G4 box; other site 885276010816 G5 box; other site 885276010817 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 885276010818 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 885276010819 Antibiotic Binding Site [chemical binding]; other site 885276010820 elongation factor G; Reviewed; Region: PRK00007 885276010821 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 885276010822 G1 box; other site 885276010823 putative GEF interaction site [polypeptide binding]; other site 885276010824 GTP/Mg2+ binding site [chemical binding]; other site 885276010825 Switch I region; other site 885276010826 G2 box; other site 885276010827 G3 box; other site 885276010828 Switch II region; other site 885276010829 G4 box; other site 885276010830 G5 box; other site 885276010831 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 885276010832 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 885276010833 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 885276010834 30S ribosomal protein S7; Validated; Region: PRK05302 885276010835 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 885276010836 S17 interaction site [polypeptide binding]; other site 885276010837 S8 interaction site; other site 885276010838 16S rRNA interaction site [nucleotide binding]; other site 885276010839 streptomycin interaction site [chemical binding]; other site 885276010840 23S rRNA interaction site [nucleotide binding]; other site 885276010841 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 885276010842 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 885276010843 sulfur relay protein TusC; Validated; Region: PRK00211 885276010844 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 885276010845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 885276010846 YheO-like PAS domain; Region: PAS_6; pfam08348 885276010847 HTH domain; Region: HTH_22; pfam13309 885276010848 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 885276010849 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 885276010850 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885276010851 phi X174 lysis protein; Provisional; Region: PRK02793 885276010852 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 885276010853 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885276010854 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 885276010855 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 885276010856 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 885276010857 TrkA-N domain; Region: TrkA_N; pfam02254 885276010858 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 885276010859 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 885276010860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276010861 Walker A/P-loop; other site 885276010862 ATP binding site [chemical binding]; other site 885276010863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885276010864 ABC transporter signature motif; other site 885276010865 Walker B; other site 885276010866 D-loop; other site 885276010867 ABC transporter; Region: ABC_tran_2; pfam12848 885276010868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885276010869 putative hydrolase; Provisional; Region: PRK10985 885276010870 hypothetical protein; Provisional; Region: PRK04966 885276010871 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 885276010872 active site 885276010873 hypothetical protein; Provisional; Region: PRK10738 885276010874 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 885276010875 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 885276010876 ligand binding site [chemical binding]; other site 885276010877 flexible hinge region; other site 885276010878 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 885276010879 putative switch regulator; other site 885276010880 non-specific DNA interactions [nucleotide binding]; other site 885276010881 DNA binding site [nucleotide binding] 885276010882 sequence specific DNA binding site [nucleotide binding]; other site 885276010883 putative cAMP binding site [chemical binding]; other site 885276010884 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 885276010885 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 885276010886 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885276010887 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 885276010888 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 885276010889 inhibitor-cofactor binding pocket; inhibition site 885276010890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276010891 catalytic residue [active] 885276010892 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 885276010893 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 885276010894 glutamine binding [chemical binding]; other site 885276010895 catalytic triad [active] 885276010896 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 885276010897 cell filamentation protein Fic; Provisional; Region: PRK10347 885276010898 hypothetical protein; Provisional; Region: PRK10204 885276010899 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 885276010900 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 885276010901 substrate binding site [chemical binding]; other site 885276010902 putative transporter; Provisional; Region: PRK03699 885276010903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276010904 putative substrate translocation pore; other site 885276010905 nitrite reductase subunit NirD; Provisional; Region: PRK14989 885276010906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276010907 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 885276010908 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 885276010909 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 885276010910 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 885276010911 nitrite transporter NirC; Provisional; Region: PRK11562 885276010912 siroheme synthase; Provisional; Region: cysG; PRK10637 885276010913 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 885276010914 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 885276010915 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 885276010916 active site 885276010917 SAM binding site [chemical binding]; other site 885276010918 homodimer interface [polypeptide binding]; other site 885276010919 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 885276010920 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 885276010921 Protein of unknown function; Region: YhfT; pfam10797 885276010922 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 885276010923 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 885276010924 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 885276010925 active site 885276010926 substrate binding pocket [chemical binding]; other site 885276010927 homodimer interaction site [polypeptide binding]; other site 885276010928 putative mutase; Provisional; Region: PRK12383 885276010929 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 885276010930 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 885276010931 dimer interface [polypeptide binding]; other site 885276010932 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 885276010933 active site 885276010934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885276010935 substrate binding site [chemical binding]; other site 885276010936 catalytic residue [active] 885276010937 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 885276010938 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 885276010939 active site 885276010940 HIGH motif; other site 885276010941 dimer interface [polypeptide binding]; other site 885276010942 KMSKS motif; other site 885276010943 phosphoglycolate phosphatase; Provisional; Region: PRK13222 885276010944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276010945 motif II; other site 885276010946 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 885276010947 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 885276010948 substrate binding site [chemical binding]; other site 885276010949 hexamer interface [polypeptide binding]; other site 885276010950 metal binding site [ion binding]; metal-binding site 885276010951 DNA adenine methylase; Provisional; Region: PRK10904 885276010952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 885276010953 cell division protein DamX; Validated; Region: PRK10905 885276010954 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 885276010955 active site 885276010956 dimer interface [polypeptide binding]; other site 885276010957 metal binding site [ion binding]; metal-binding site 885276010958 shikimate kinase; Reviewed; Region: aroK; PRK00131 885276010959 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 885276010960 ADP binding site [chemical binding]; other site 885276010961 magnesium binding site [ion binding]; other site 885276010962 putative shikimate binding site; other site 885276010963 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 885276010964 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 885276010965 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 885276010966 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 885276010967 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 885276010968 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 885276010969 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 885276010970 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 885276010971 Transglycosylase; Region: Transgly; pfam00912 885276010972 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 885276010973 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 885276010974 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 885276010975 ADP-ribose binding site [chemical binding]; other site 885276010976 dimer interface [polypeptide binding]; other site 885276010977 active site 885276010978 nudix motif; other site 885276010979 metal binding site [ion binding]; metal-binding site 885276010980 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 885276010981 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 885276010982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276010983 motif II; other site 885276010984 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276010985 RNA binding surface [nucleotide binding]; other site 885276010986 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 885276010987 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 885276010988 dimerization interface [polypeptide binding]; other site 885276010989 domain crossover interface; other site 885276010990 redox-dependent activation switch; other site 885276010991 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 885276010992 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 885276010993 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 885276010994 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 885276010995 active site 885276010996 substrate-binding site [chemical binding]; other site 885276010997 metal-binding site [ion binding] 885276010998 ATP binding site [chemical binding]; other site 885276010999 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 885276011000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276011001 non-specific DNA binding site [nucleotide binding]; other site 885276011002 salt bridge; other site 885276011003 sequence-specific DNA binding site [nucleotide binding]; other site 885276011004 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 885276011005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276011006 dimerization interface [polypeptide binding]; other site 885276011007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276011008 dimer interface [polypeptide binding]; other site 885276011009 phosphorylation site [posttranslational modification] 885276011010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276011011 ATP binding site [chemical binding]; other site 885276011012 G-X-G motif; other site 885276011013 osmolarity response regulator; Provisional; Region: ompR; PRK09468 885276011014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276011015 active site 885276011016 phosphorylation site [posttranslational modification] 885276011017 intermolecular recognition site; other site 885276011018 dimerization interface [polypeptide binding]; other site 885276011019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276011020 DNA binding site [nucleotide binding] 885276011021 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 885276011022 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 885276011023 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 885276011024 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 885276011025 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 885276011026 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 885276011027 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 885276011028 RNA binding site [nucleotide binding]; other site 885276011029 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 885276011030 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 885276011031 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 885276011032 G1 box; other site 885276011033 GTP/Mg2+ binding site [chemical binding]; other site 885276011034 Switch I region; other site 885276011035 G2 box; other site 885276011036 G3 box; other site 885276011037 Switch II region; other site 885276011038 G4 box; other site 885276011039 G5 box; other site 885276011040 Nucleoside recognition; Region: Gate; pfam07670 885276011041 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 885276011042 Nucleoside recognition; Region: Gate; pfam07670 885276011043 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 885276011044 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885276011045 carboxylesterase BioH; Provisional; Region: PRK10349 885276011046 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 885276011047 DNA utilization protein GntX; Provisional; Region: PRK11595 885276011048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276011049 active site 885276011050 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 885276011051 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 885276011052 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 885276011053 high-affinity gluconate transporter; Provisional; Region: PRK14984 885276011054 gluconate transporter; Region: gntP; TIGR00791 885276011055 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 885276011056 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 885276011057 maltodextrin phosphorylase; Provisional; Region: PRK14985 885276011058 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 885276011059 homodimer interface [polypeptide binding]; other site 885276011060 active site pocket [active] 885276011061 transcriptional regulator MalT; Provisional; Region: PRK04841 885276011062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276011063 DNA binding residues [nucleotide binding] 885276011064 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 885276011065 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 885276011066 putative active site [active] 885276011067 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 885276011068 hypothetical protein; Reviewed; Region: PRK09588 885276011069 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 885276011070 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 885276011071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276011072 Walker A motif; other site 885276011073 ATP binding site [chemical binding]; other site 885276011074 Walker B motif; other site 885276011075 arginine finger; other site 885276011076 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 885276011077 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276011078 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276011079 intramembrane serine protease GlpG; Provisional; Region: PRK10907 885276011080 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 885276011081 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 885276011082 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 885276011083 active site residue [active] 885276011084 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 885276011085 hypothetical protein; Provisional; Region: PRK09781; cl08057 885276011086 Fimbrial protein; Region: Fimbrial; cl01416 885276011087 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 885276011088 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276011089 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276011090 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276011091 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276011092 outer membrane usher protein; Provisional; Region: PRK15193 885276011093 PapC N-terminal domain; Region: PapC_N; pfam13954 885276011094 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276011095 PapC C-terminal domain; Region: PapC_C; pfam13953 885276011096 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 885276011097 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276011098 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276011099 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276011100 glycogen phosphorylase; Provisional; Region: PRK14986 885276011101 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 885276011102 homodimer interface [polypeptide binding]; other site 885276011103 active site pocket [active] 885276011104 glycogen synthase; Provisional; Region: glgA; PRK00654 885276011105 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 885276011106 ADP-binding pocket [chemical binding]; other site 885276011107 homodimer interface [polypeptide binding]; other site 885276011108 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 885276011109 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 885276011110 ligand binding site; other site 885276011111 oligomer interface; other site 885276011112 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 885276011113 sulfate 1 binding site; other site 885276011114 glycogen debranching enzyme; Provisional; Region: PRK03705 885276011115 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 885276011116 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 885276011117 active site 885276011118 catalytic site [active] 885276011119 glycogen branching enzyme; Provisional; Region: PRK05402 885276011120 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 885276011121 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 885276011122 active site 885276011123 catalytic site [active] 885276011124 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 885276011125 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 885276011126 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 885276011127 putative antibiotic transporter; Provisional; Region: PRK10739 885276011128 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 885276011129 DNA protecting protein DprA; Region: dprA; TIGR00732 885276011130 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 885276011131 non-specific DNA interactions [nucleotide binding]; other site 885276011132 DNA binding site [nucleotide binding] 885276011133 sequence specific DNA binding site [nucleotide binding]; other site 885276011134 putative cAMP binding site [chemical binding]; other site 885276011135 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 885276011136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276011137 ATP binding site [chemical binding]; other site 885276011138 putative Mg++ binding site [ion binding]; other site 885276011139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276011140 nucleotide binding region [chemical binding]; other site 885276011141 ATP-binding site [chemical binding]; other site 885276011142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276011143 active site 885276011144 low affinity gluconate transporter; Provisional; Region: PRK10472 885276011145 gluconate transporter; Region: gntP; TIGR00791 885276011146 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 885276011147 ATP-binding site [chemical binding]; other site 885276011148 Gluconate-6-phosphate binding site [chemical binding]; other site 885276011149 Shikimate kinase; Region: SKI; pfam01202 885276011150 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 885276011151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276011152 DNA binding site [nucleotide binding] 885276011153 domain linker motif; other site 885276011154 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 885276011155 putative ligand binding site [chemical binding]; other site 885276011156 putative dimerization interface [polypeptide binding]; other site 885276011157 Pirin-related protein [General function prediction only]; Region: COG1741 885276011158 Pirin; Region: Pirin; pfam02678 885276011159 putative oxidoreductase; Provisional; Region: PRK10206 885276011160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 885276011161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 885276011162 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 885276011163 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 885276011164 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 885276011165 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 885276011166 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 885276011167 hypothetical protein; Provisional; Region: PRK10350 885276011168 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 885276011169 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 885276011170 putative active site [active] 885276011171 catalytic site [active] 885276011172 putative metal binding site [ion binding]; other site 885276011173 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 885276011174 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 885276011175 Walker A/P-loop; other site 885276011176 ATP binding site [chemical binding]; other site 885276011177 Q-loop/lid; other site 885276011178 ABC transporter signature motif; other site 885276011179 Walker B; other site 885276011180 D-loop; other site 885276011181 H-loop/switch region; other site 885276011182 TOBE domain; Region: TOBE_2; pfam08402 885276011183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 885276011184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276011185 dimer interface [polypeptide binding]; other site 885276011186 conserved gate region; other site 885276011187 putative PBP binding loops; other site 885276011188 ABC-ATPase subunit interface; other site 885276011189 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 885276011190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276011191 dimer interface [polypeptide binding]; other site 885276011192 conserved gate region; other site 885276011193 putative PBP binding loops; other site 885276011194 ABC-ATPase subunit interface; other site 885276011195 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 885276011196 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 885276011197 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 885276011198 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 885276011199 Walker A/P-loop; other site 885276011200 ATP binding site [chemical binding]; other site 885276011201 Q-loop/lid; other site 885276011202 ABC transporter signature motif; other site 885276011203 Walker B; other site 885276011204 D-loop; other site 885276011205 H-loop/switch region; other site 885276011206 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 885276011207 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 885276011208 Walker A/P-loop; other site 885276011209 ATP binding site [chemical binding]; other site 885276011210 Q-loop/lid; other site 885276011211 ABC transporter signature motif; other site 885276011212 Walker B; other site 885276011213 D-loop; other site 885276011214 H-loop/switch region; other site 885276011215 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 885276011216 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 885276011217 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 885276011218 TM-ABC transporter signature motif; other site 885276011219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276011220 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 885276011221 TM-ABC transporter signature motif; other site 885276011222 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 885276011223 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 885276011224 dimerization interface [polypeptide binding]; other site 885276011225 ligand binding site [chemical binding]; other site 885276011226 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 885276011227 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885276011228 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 885276011229 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 885276011230 dimerization interface [polypeptide binding]; other site 885276011231 ligand binding site [chemical binding]; other site 885276011232 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 885276011233 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 885276011234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 885276011235 DNA binding residues [nucleotide binding] 885276011236 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 885276011237 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 885276011238 cell division protein FtsE; Provisional; Region: PRK10908 885276011239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276011240 Walker A/P-loop; other site 885276011241 ATP binding site [chemical binding]; other site 885276011242 Q-loop/lid; other site 885276011243 ABC transporter signature motif; other site 885276011244 Walker B; other site 885276011245 D-loop; other site 885276011246 H-loop/switch region; other site 885276011247 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 885276011248 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 885276011249 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 885276011250 P loop; other site 885276011251 GTP binding site [chemical binding]; other site 885276011252 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 885276011253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276011254 S-adenosylmethionine binding site [chemical binding]; other site 885276011255 hypothetical protein; Provisional; Region: PRK10910 885276011256 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 885276011257 Predicted membrane protein [Function unknown]; Region: COG3714 885276011258 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 885276011259 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 885276011260 metal-binding site [ion binding] 885276011261 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885276011262 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 885276011263 CPxP motif; other site 885276011264 hypothetical protein; Provisional; Region: PRK11212 885276011265 hypothetical protein; Provisional; Region: PRK11615 885276011266 major facilitator superfamily transporter; Provisional; Region: PRK05122 885276011267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276011268 putative substrate translocation pore; other site 885276011269 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 885276011270 Domain of unknown function DUF20; Region: UPF0118; pfam01594 885276011271 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 885276011272 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 885276011273 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 885276011274 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 885276011275 substrate binding site [chemical binding]; other site 885276011276 nickel transporter permease NikB; Provisional; Region: PRK10352 885276011277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276011278 dimer interface [polypeptide binding]; other site 885276011279 conserved gate region; other site 885276011280 putative PBP binding loops; other site 885276011281 ABC-ATPase subunit interface; other site 885276011282 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 885276011283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276011284 dimer interface [polypeptide binding]; other site 885276011285 conserved gate region; other site 885276011286 putative PBP binding loops; other site 885276011287 ABC-ATPase subunit interface; other site 885276011288 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 885276011289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276011290 Walker A/P-loop; other site 885276011291 ATP binding site [chemical binding]; other site 885276011292 Q-loop/lid; other site 885276011293 ABC transporter signature motif; other site 885276011294 Walker B; other site 885276011295 D-loop; other site 885276011296 H-loop/switch region; other site 885276011297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885276011298 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 885276011299 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276011300 Walker A/P-loop; other site 885276011301 ATP binding site [chemical binding]; other site 885276011302 Q-loop/lid; other site 885276011303 ABC transporter signature motif; other site 885276011304 Walker B; other site 885276011305 D-loop; other site 885276011306 H-loop/switch region; other site 885276011307 nickel responsive regulator; Provisional; Region: PRK02967 885276011308 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 885276011309 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 885276011310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276011311 DNA-binding site [nucleotide binding]; DNA binding site 885276011312 UTRA domain; Region: UTRA; pfam07702 885276011313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276011314 active site 885276011315 phosphorylation site [posttranslational modification] 885276011316 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 885276011317 active site 885276011318 P-loop; other site 885276011319 phosphorylation site [posttranslational modification] 885276011320 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 885276011321 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 885276011322 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 885276011323 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 885276011324 putative N- and C-terminal domain interface [polypeptide binding]; other site 885276011325 putative active site [active] 885276011326 putative MgATP binding site [chemical binding]; other site 885276011327 catalytic site [active] 885276011328 metal binding site [ion binding]; metal-binding site 885276011329 putative carbohydrate binding site [chemical binding]; other site 885276011330 seadornavirus RNA-directed RNA polymerase; Region: seadorna_RNAP; TIGR04234 885276011331 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276011332 dimerization domain swap beta strand [polypeptide binding]; other site 885276011333 regulatory protein interface [polypeptide binding]; other site 885276011334 active site 885276011335 regulatory phosphorylation site [posttranslational modification]; other site 885276011336 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885276011337 intersubunit interface [polypeptide binding]; other site 885276011338 active site 885276011339 zinc binding site [ion binding]; other site 885276011340 Na+ binding site [ion binding]; other site 885276011341 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885276011342 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 885276011343 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885276011344 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 885276011345 Walker A/P-loop; other site 885276011346 ATP binding site [chemical binding]; other site 885276011347 Q-loop/lid; other site 885276011348 ABC transporter signature motif; other site 885276011349 Walker B; other site 885276011350 D-loop; other site 885276011351 H-loop/switch region; other site 885276011352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 885276011353 Walker A/P-loop; other site 885276011354 ATP binding site [chemical binding]; other site 885276011355 Q-loop/lid; other site 885276011356 ABC transporter signature motif; other site 885276011357 Walker B; other site 885276011358 D-loop; other site 885276011359 H-loop/switch region; other site 885276011360 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 885276011361 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 885276011362 HlyD family secretion protein; Region: HlyD; pfam00529 885276011363 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276011364 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276011365 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 885276011366 Predicted flavoproteins [General function prediction only]; Region: COG2081 885276011367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276011368 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885276011369 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 885276011370 universal stress protein UspB; Provisional; Region: PRK04960 885276011371 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276011372 Ligand Binding Site [chemical binding]; other site 885276011373 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 885276011374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276011375 POT family; Region: PTR2; pfam00854 885276011376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276011377 S-adenosylmethionine binding site [chemical binding]; other site 885276011378 oligopeptidase A; Provisional; Region: PRK10911 885276011379 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 885276011380 active site 885276011381 Zn binding site [ion binding]; other site 885276011382 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 885276011383 glutathione reductase; Validated; Region: PRK06116 885276011384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 885276011385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276011386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885276011387 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 885276011388 ArsC family; Region: ArsC; pfam03960 885276011389 catalytic residues [active] 885276011390 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 885276011391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276011392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276011393 DNA binding residues [nucleotide binding] 885276011394 dimerization interface [polypeptide binding]; other site 885276011395 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 885276011396 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 885276011397 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 885276011398 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 885276011399 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276011400 N-terminal plug; other site 885276011401 ligand-binding site [chemical binding]; other site 885276011402 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 885276011403 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 885276011404 putative hemin binding site; other site 885276011405 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 885276011406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276011407 FeS/SAM binding site; other site 885276011408 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 885276011409 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 885276011410 NADH(P)-binding; Region: NAD_binding_10; pfam13460 885276011411 NAD(P) binding site [chemical binding]; other site 885276011412 putative active site [active] 885276011413 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 885276011414 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 885276011415 ABC-ATPase subunit interface; other site 885276011416 dimer interface [polypeptide binding]; other site 885276011417 putative PBP binding regions; other site 885276011418 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 885276011419 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 885276011420 Walker A/P-loop; other site 885276011421 ATP binding site [chemical binding]; other site 885276011422 Q-loop/lid; other site 885276011423 ABC transporter signature motif; other site 885276011424 Walker B; other site 885276011425 D-loop; other site 885276011426 H-loop/switch region; other site 885276011427 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 885276011428 MgtC family; Region: MgtC; pfam02308 885276011429 acid-resistance protein; Provisional; Region: hdeB; PRK11566 885276011430 acid-resistance protein; Provisional; Region: PRK10208 885276011431 acid-resistance membrane protein; Provisional; Region: PRK10209 885276011432 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 885276011433 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 885276011434 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 885276011435 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276011436 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276011437 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 885276011438 Protein export membrane protein; Region: SecD_SecF; cl14618 885276011439 transcriptional regulator YdeO; Provisional; Region: PRK09940 885276011440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276011441 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 885276011442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276011443 catalytic residue [active] 885276011444 Haem-binding domain; Region: Haem_bd; pfam14376 885276011445 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 885276011446 trehalase; Provisional; Region: treF; PRK13270 885276011447 Trehalase; Region: Trehalase; pfam01204 885276011448 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276011449 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276011450 DNA binding residues [nucleotide binding] 885276011451 dimerization interface [polypeptide binding]; other site 885276011452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276011453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276011454 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 885276011455 putative effector binding pocket; other site 885276011456 putative dimerization interface [polypeptide binding]; other site 885276011457 inner membrane protein YhjD; Region: TIGR00766 885276011458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276011459 metabolite-proton symporter; Region: 2A0106; TIGR00883 885276011460 putative substrate translocation pore; other site 885276011461 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 885276011462 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 885276011463 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276011464 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276011465 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 885276011466 substrate binding site [chemical binding]; other site 885276011467 ATP binding site [chemical binding]; other site 885276011468 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 885276011469 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 885276011470 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 885276011471 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885276011472 putative diguanylate cyclase; Provisional; Region: PRK13561 885276011473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 885276011474 metal binding site [ion binding]; metal-binding site 885276011475 active site 885276011476 I-site; other site 885276011477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276011478 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 885276011479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276011480 binding surface 885276011481 TPR motif; other site 885276011482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276011483 binding surface 885276011484 TPR motif; other site 885276011485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 885276011486 TPR motif; other site 885276011487 binding surface 885276011488 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 885276011489 endo-1,4-D-glucanase; Provisional; Region: PRK11097 885276011490 cellulose synthase regulator protein; Provisional; Region: PRK11114 885276011491 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 885276011492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 885276011493 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 885276011494 DXD motif; other site 885276011495 PilZ domain; Region: PilZ; pfam07238 885276011496 cell division protein; Provisional; Region: PRK10037 885276011497 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 885276011498 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 885276011499 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 885276011500 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 885276011501 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 885276011502 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 885276011503 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 885276011504 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 885276011505 serine transporter; Region: stp; TIGR00814 885276011506 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 885276011507 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276011508 Walker A/P-loop; other site 885276011509 ATP binding site [chemical binding]; other site 885276011510 Q-loop/lid; other site 885276011511 ABC transporter signature motif; other site 885276011512 Walker B; other site 885276011513 D-loop; other site 885276011514 H-loop/switch region; other site 885276011515 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885276011516 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 885276011517 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276011518 Walker A/P-loop; other site 885276011519 ATP binding site [chemical binding]; other site 885276011520 Q-loop/lid; other site 885276011521 ABC transporter signature motif; other site 885276011522 Walker B; other site 885276011523 D-loop; other site 885276011524 H-loop/switch region; other site 885276011525 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 885276011526 dipeptide transporter; Provisional; Region: PRK10913 885276011527 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885276011528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276011529 dimer interface [polypeptide binding]; other site 885276011530 conserved gate region; other site 885276011531 putative PBP binding loops; other site 885276011532 ABC-ATPase subunit interface; other site 885276011533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 885276011534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276011535 dimer interface [polypeptide binding]; other site 885276011536 conserved gate region; other site 885276011537 putative PBP binding loops; other site 885276011538 ABC-ATPase subunit interface; other site 885276011539 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 885276011540 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 885276011541 peptide binding site [polypeptide binding]; other site 885276011542 phosphoethanolamine transferase; Provisional; Region: PRK11560 885276011543 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 885276011544 Sulfatase; Region: Sulfatase; pfam00884 885276011545 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 885276011546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276011547 putative substrate translocation pore; other site 885276011548 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 885276011549 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 885276011550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 885276011551 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276011552 Coenzyme A binding pocket [chemical binding]; other site 885276011553 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 885276011554 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 885276011555 molybdopterin cofactor binding site [chemical binding]; other site 885276011556 substrate binding site [chemical binding]; other site 885276011557 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 885276011558 molybdopterin cofactor binding site; other site 885276011559 putative outer membrane lipoprotein; Provisional; Region: PRK10510 885276011560 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 885276011561 ligand binding site [chemical binding]; other site 885276011562 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 885276011563 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 885276011564 dimerization interface [polypeptide binding]; other site 885276011565 ligand binding site [chemical binding]; other site 885276011566 NADP binding site [chemical binding]; other site 885276011567 catalytic site [active] 885276011568 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 885276011569 Predicted transcriptional regulator [Transcription]; Region: COG2944 885276011570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276011571 non-specific DNA binding site [nucleotide binding]; other site 885276011572 salt bridge; other site 885276011573 sequence-specific DNA binding site [nucleotide binding]; other site 885276011574 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 885276011575 DNA-binding site [nucleotide binding]; DNA binding site 885276011576 RNA-binding motif; other site 885276011577 small toxic polypeptide; Provisional; Region: PRK09759 885276011578 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 885276011579 DALR anticodon binding domain; Region: DALR_1; pfam05746 885276011580 anticodon binding site; other site 885276011581 tRNA binding surface [nucleotide binding]; other site 885276011582 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 885276011583 dimer interface [polypeptide binding]; other site 885276011584 motif 1; other site 885276011585 active site 885276011586 motif 2; other site 885276011587 motif 3; other site 885276011588 YsaB-like lipoprotein; Region: YsaB; pfam13983 885276011589 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 885276011590 Acyltransferase family; Region: Acyl_transf_3; pfam01757 885276011591 hypothetical protein; Provisional; Region: PRK11383 885276011592 yiaA/B two helix domain; Region: YiaAB; pfam05360 885276011593 yiaA/B two helix domain; Region: YiaAB; pfam05360 885276011594 hypothetical protein; Provisional; Region: PRK11403 885276011595 yiaA/B two helix domain; Region: YiaAB; pfam05360 885276011596 xylulokinase; Provisional; Region: PRK15027 885276011597 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 885276011598 N- and C-terminal domain interface [polypeptide binding]; other site 885276011599 active site 885276011600 MgATP binding site [chemical binding]; other site 885276011601 catalytic site [active] 885276011602 metal binding site [ion binding]; metal-binding site 885276011603 xylulose binding site [chemical binding]; other site 885276011604 homodimer interface [polypeptide binding]; other site 885276011605 xylose isomerase; Provisional; Region: PRK05474 885276011606 xylose isomerase; Region: xylose_isom_A; TIGR02630 885276011607 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 885276011608 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 885276011609 putative ligand binding site [chemical binding]; other site 885276011610 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 885276011611 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276011612 Walker A/P-loop; other site 885276011613 ATP binding site [chemical binding]; other site 885276011614 Q-loop/lid; other site 885276011615 ABC transporter signature motif; other site 885276011616 Walker B; other site 885276011617 D-loop; other site 885276011618 H-loop/switch region; other site 885276011619 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276011620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276011621 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276011622 TM-ABC transporter signature motif; other site 885276011623 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 885276011624 putative dimerization interface [polypeptide binding]; other site 885276011625 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885276011626 putative ligand binding site [chemical binding]; other site 885276011627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276011628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276011629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276011630 hypothetical protein; Provisional; Region: PRK10356 885276011631 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 885276011632 alpha-amylase; Reviewed; Region: malS; PRK09505 885276011633 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 885276011634 active site 885276011635 catalytic site [active] 885276011636 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 885276011637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276011638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276011639 homodimer interface [polypeptide binding]; other site 885276011640 catalytic residue [active] 885276011641 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 885276011642 Transcriptional regulator [Transcription]; Region: IclR; COG1414 885276011643 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885276011644 Bacterial transcriptional regulator; Region: IclR; pfam01614 885276011645 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 885276011646 Domain of unknown function (DUF386); Region: DUF386; pfam04074 885276011647 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 885276011648 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 885276011649 DctM-like transporters; Region: DctM; pfam06808 885276011650 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 885276011651 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 885276011652 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 885276011653 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 885276011654 putative N- and C-terminal domain interface [polypeptide binding]; other site 885276011655 putative active site [active] 885276011656 MgATP binding site [chemical binding]; other site 885276011657 catalytic site [active] 885276011658 metal binding site [ion binding]; metal-binding site 885276011659 putative xylulose binding site [chemical binding]; other site 885276011660 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 885276011661 active site 885276011662 dimer interface [polypeptide binding]; other site 885276011663 magnesium binding site [ion binding]; other site 885276011664 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 885276011665 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 885276011666 AP (apurinic/apyrimidinic) site pocket; other site 885276011667 DNA interaction; other site 885276011668 Metal-binding active site; metal-binding site 885276011669 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885276011670 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885276011671 intersubunit interface [polypeptide binding]; other site 885276011672 active site 885276011673 Zn2+ binding site [ion binding]; other site 885276011674 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 885276011675 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 885276011676 NAD(P) binding site [chemical binding]; other site 885276011677 catalytic residues [active] 885276011678 Fic family protein [Function unknown]; Region: COG3177 885276011679 Fic/DOC family; Region: Fic; pfam02661 885276011680 putative alcohol dehydrogenase; Provisional; Region: PRK09860 885276011681 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 885276011682 dimer interface [polypeptide binding]; other site 885276011683 active site 885276011684 metal binding site [ion binding]; metal-binding site 885276011685 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 885276011686 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 885276011687 G1 box; other site 885276011688 putative GEF interaction site [polypeptide binding]; other site 885276011689 GTP/Mg2+ binding site [chemical binding]; other site 885276011690 Switch I region; other site 885276011691 G2 box; other site 885276011692 G3 box; other site 885276011693 Switch II region; other site 885276011694 G4 box; other site 885276011695 G5 box; other site 885276011696 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 885276011697 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 885276011698 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 885276011699 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 885276011700 selenocysteine synthase; Provisional; Region: PRK04311 885276011701 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 885276011702 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 885276011703 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276011704 catalytic residue [active] 885276011705 putative glutathione S-transferase; Provisional; Region: PRK10357 885276011706 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 885276011707 putative C-terminal domain interface [polypeptide binding]; other site 885276011708 putative GSH binding site (G-site) [chemical binding]; other site 885276011709 putative dimer interface [polypeptide binding]; other site 885276011710 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 885276011711 dimer interface [polypeptide binding]; other site 885276011712 N-terminal domain interface [polypeptide binding]; other site 885276011713 putative substrate binding pocket (H-site) [chemical binding]; other site 885276011714 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 885276011715 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276011716 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276011717 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 885276011718 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 885276011719 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 885276011720 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 885276011721 active site 885276011722 P-loop; other site 885276011723 phosphorylation site [posttranslational modification] 885276011724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276011725 active site 885276011726 phosphorylation site [posttranslational modification] 885276011727 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885276011728 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 885276011729 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885276011730 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885276011731 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 885276011732 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 885276011733 hypothetical protein; Provisional; Region: PRK11020 885276011734 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 885276011735 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885276011736 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 885276011737 trimer interface [polypeptide binding]; other site 885276011738 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 885276011739 trimer interface [polypeptide binding]; other site 885276011740 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 885276011741 Haemagglutinin; Region: HIM; pfam05662 885276011742 Haemagglutinin; Region: HIM; pfam05662 885276011743 YadA-like C-terminal region; Region: YadA; pfam03895 885276011744 L-lactate permease; Provisional; Region: PRK10420 885276011745 glycolate transporter; Provisional; Region: PRK09695 885276011746 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 885276011747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276011748 DNA-binding site [nucleotide binding]; DNA binding site 885276011749 FCD domain; Region: FCD; pfam07729 885276011750 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 885276011751 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 885276011752 phosphate binding site [ion binding]; other site 885276011753 putative rRNA methylase; Provisional; Region: PRK10358 885276011754 serine acetyltransferase; Provisional; Region: cysE; PRK11132 885276011755 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 885276011756 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 885276011757 trimer interface [polypeptide binding]; other site 885276011758 active site 885276011759 substrate binding site [chemical binding]; other site 885276011760 CoA binding site [chemical binding]; other site 885276011761 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 885276011762 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 885276011763 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 885276011764 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 885276011765 SecA binding site; other site 885276011766 Preprotein binding site; other site 885276011767 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 885276011768 GSH binding site [chemical binding]; other site 885276011769 catalytic residues [active] 885276011770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 885276011771 active site residue [active] 885276011772 phosphoglyceromutase; Provisional; Region: PRK05434 885276011773 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 885276011774 AmiB activator; Provisional; Region: PRK11637 885276011775 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 885276011776 Peptidase family M23; Region: Peptidase_M23; pfam01551 885276011777 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 885276011778 NodB motif; other site 885276011779 putative active site [active] 885276011780 putative catalytic site [active] 885276011781 Zn binding site [ion binding]; other site 885276011782 putative glycosyl transferase; Provisional; Region: PRK10073 885276011783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885276011784 active site 885276011785 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 885276011786 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 885276011787 NAD(P) binding site [chemical binding]; other site 885276011788 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 885276011789 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 885276011790 substrate-cofactor binding pocket; other site 885276011791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276011792 catalytic residue [active] 885276011793 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 885276011794 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 885276011795 NADP binding site [chemical binding]; other site 885276011796 homopentamer interface [polypeptide binding]; other site 885276011797 substrate binding site [chemical binding]; other site 885276011798 active site 885276011799 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 885276011800 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 885276011801 putative active site [active] 885276011802 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 885276011803 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 885276011804 putative active site [active] 885276011805 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 885276011806 O-Antigen ligase; Region: Wzy_C; pfam04932 885276011807 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 885276011808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 885276011809 active site 885276011810 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 885276011811 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 885276011812 Ligand binding site; other site 885276011813 metal-binding site 885276011814 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 885276011815 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 885276011816 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 885276011817 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 885276011818 Ligand binding site; other site 885276011819 metal-binding site 885276011820 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 885276011821 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 885276011822 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 885276011823 Ligand binding site; other site 885276011824 metal-binding site 885276011825 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 885276011826 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 885276011827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 885276011828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 885276011829 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 885276011830 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 885276011831 putative active site [active] 885276011832 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 885276011833 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 885276011834 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 885276011835 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 885276011836 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 885276011837 active site 885276011838 (T/H)XGH motif; other site 885276011839 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 885276011840 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 885276011841 DNA binding site [nucleotide binding] 885276011842 catalytic residue [active] 885276011843 H2TH interface [polypeptide binding]; other site 885276011844 putative catalytic residues [active] 885276011845 turnover-facilitating residue; other site 885276011846 intercalation triad [nucleotide binding]; other site 885276011847 8OG recognition residue [nucleotide binding]; other site 885276011848 putative reading head residues; other site 885276011849 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 885276011850 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 885276011851 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 885276011852 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 885276011853 hypothetical protein; Reviewed; Region: PRK00024 885276011854 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885276011855 MPN+ (JAMM) motif; other site 885276011856 Zinc-binding site [ion binding]; other site 885276011857 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 885276011858 Flavoprotein; Region: Flavoprotein; pfam02441 885276011859 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 885276011860 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 885276011861 trimer interface [polypeptide binding]; other site 885276011862 active site 885276011863 division inhibitor protein; Provisional; Region: slmA; PRK09480 885276011864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276011865 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 885276011866 active site 885276011867 ribonuclease PH; Reviewed; Region: rph; PRK00173 885276011868 Ribonuclease PH; Region: RNase_PH_bact; cd11362 885276011869 hexamer interface [polypeptide binding]; other site 885276011870 active site 885276011871 hypothetical protein; Provisional; Region: PRK11820 885276011872 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 885276011873 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 885276011874 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 885276011875 BRO family, N-terminal domain; Region: Bro-N; pfam02498 885276011876 Predicted membrane protein [Function unknown]; Region: COG2860 885276011877 UPF0126 domain; Region: UPF0126; pfam03458 885276011878 UPF0126 domain; Region: UPF0126; pfam03458 885276011879 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 885276011880 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 885276011881 nucleotide binding pocket [chemical binding]; other site 885276011882 K-X-D-G motif; other site 885276011883 catalytic site [active] 885276011884 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 885276011885 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 885276011886 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 885276011887 catalytic site [active] 885276011888 G-X2-G-X-G-K; other site 885276011889 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 885276011890 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 885276011891 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 885276011892 Zn2+ binding site [ion binding]; other site 885276011893 Mg2+ binding site [ion binding]; other site 885276011894 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 885276011895 synthetase active site [active] 885276011896 NTP binding site [chemical binding]; other site 885276011897 metal binding site [ion binding]; metal-binding site 885276011898 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 885276011899 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 885276011900 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 885276011901 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 885276011902 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 885276011903 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 885276011904 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 885276011905 generic binding surface II; other site 885276011906 ssDNA binding site; other site 885276011907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276011908 ATP binding site [chemical binding]; other site 885276011909 putative Mg++ binding site [ion binding]; other site 885276011910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276011911 nucleotide binding region [chemical binding]; other site 885276011912 ATP-binding site [chemical binding]; other site 885276011913 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 885276011914 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 885276011915 AsmA family; Region: AsmA; pfam05170 885276011916 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 885276011917 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 885276011918 fructokinase; Reviewed; Region: PRK09557 885276011919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276011920 nucleotide binding site [chemical binding]; other site 885276011921 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885276011922 intersubunit interface [polypeptide binding]; other site 885276011923 active site 885276011924 zinc binding site [ion binding]; other site 885276011925 Na+ binding site [ion binding]; other site 885276011926 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 885276011927 intersubunit interface [polypeptide binding]; other site 885276011928 active site 885276011929 zinc binding site [ion binding]; other site 885276011930 Na+ binding site [ion binding]; other site 885276011931 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 885276011932 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885276011933 active site 885276011934 P-loop; other site 885276011935 phosphorylation site [posttranslational modification] 885276011936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276011937 active site 885276011938 phosphorylation site [posttranslational modification] 885276011939 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 885276011940 HTH domain; Region: HTH_11; pfam08279 885276011941 Mga helix-turn-helix domain; Region: Mga; pfam05043 885276011942 PRD domain; Region: PRD; pfam00874 885276011943 PRD domain; Region: PRD; pfam00874 885276011944 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 885276011945 active site 885276011946 P-loop; other site 885276011947 phosphorylation site [posttranslational modification] 885276011948 putative alpha-glucosidase; Provisional; Region: PRK10658 885276011949 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 885276011950 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 885276011951 active site 885276011952 homotrimer interface [polypeptide binding]; other site 885276011953 catalytic site [active] 885276011954 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 885276011955 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 885276011956 putative transporter; Provisional; Region: PRK11462 885276011957 integrase; Provisional; Region: PRK09692 885276011958 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276011959 active site 885276011960 Int/Topo IB signature motif; other site 885276011961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276011962 Walker A/P-loop; other site 885276011963 ATP binding site [chemical binding]; other site 885276011964 Restriction endonuclease; Region: Mrr_cat; pfam04471 885276011965 Predicted transcriptional regulator [Transcription]; Region: COG2378 885276011966 WYL domain; Region: WYL; cl14852 885276011967 Predicted GTPase [General function prediction only]; Region: COG3596 885276011968 YfjP GTPase; Region: YfjP; cd11383 885276011969 G1 box; other site 885276011970 GTP/Mg2+ binding site [chemical binding]; other site 885276011971 Switch I region; other site 885276011972 G2 box; other site 885276011973 Switch II region; other site 885276011974 G3 box; other site 885276011975 G4 box; other site 885276011976 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 885276011977 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 885276011978 Domain of unknown function (DUF932); Region: DUF932; cl12129 885276011979 hypothetical protein; Reviewed; Region: PRK00024 885276011980 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885276011981 MPN+ (JAMM) motif; other site 885276011982 Zinc-binding site [ion binding]; other site 885276011983 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885276011984 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 885276011985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276011986 Walker A/P-loop; other site 885276011987 ATP binding site [chemical binding]; other site 885276011988 TIGR02646 family protein; Region: TIGR02646 885276011989 Virulence protein [General function prediction only]; Region: COG3943 885276011990 EamA-like transporter family; Region: EamA; pfam00892 885276011991 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 885276011992 EamA-like transporter family; Region: EamA; pfam00892 885276011993 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 885276011994 lipoprotein, YaeC family; Region: TIGR00363 885276011995 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 885276011996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276011997 putative substrate translocation pore; other site 885276011998 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 885276011999 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885276012000 cryptic adenine deaminase; Provisional; Region: PRK10027 885276012001 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 885276012002 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 885276012003 active site 885276012004 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 885276012005 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 885276012006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012007 putative substrate translocation pore; other site 885276012008 regulatory protein UhpC; Provisional; Region: PRK11663 885276012009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012010 putative substrate translocation pore; other site 885276012011 sensory histidine kinase UhpB; Provisional; Region: PRK11644 885276012012 MASE1; Region: MASE1; pfam05231 885276012013 Histidine kinase; Region: HisKA_3; pfam07730 885276012014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276012015 ATP binding site [chemical binding]; other site 885276012016 Mg2+ binding site [ion binding]; other site 885276012017 G-X-G motif; other site 885276012018 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 885276012019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276012020 active site 885276012021 phosphorylation site [posttranslational modification] 885276012022 intermolecular recognition site; other site 885276012023 dimerization interface [polypeptide binding]; other site 885276012024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276012025 DNA binding residues [nucleotide binding] 885276012026 dimerization interface [polypeptide binding]; other site 885276012027 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 885276012028 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 885276012029 putative valine binding site [chemical binding]; other site 885276012030 dimer interface [polypeptide binding]; other site 885276012031 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 885276012032 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885276012033 PYR/PP interface [polypeptide binding]; other site 885276012034 dimer interface [polypeptide binding]; other site 885276012035 TPP binding site [chemical binding]; other site 885276012036 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885276012037 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 885276012038 TPP-binding site [chemical binding]; other site 885276012039 dimer interface [polypeptide binding]; other site 885276012040 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 885276012041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012042 putative substrate translocation pore; other site 885276012043 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 885276012044 Domain of unknown function (DUF202); Region: DUF202; pfam02656 885276012045 Predicted membrane protein [Function unknown]; Region: COG2149 885276012046 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885276012047 Sulfatase; Region: Sulfatase; pfam00884 885276012048 putative transporter; Provisional; Region: PRK10484 885276012049 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 885276012050 Na binding site [ion binding]; other site 885276012051 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885276012052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276012053 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276012054 putative transporter; Validated; Region: PRK03818 885276012055 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 885276012056 TrkA-C domain; Region: TrkA_C; pfam02080 885276012057 TrkA-C domain; Region: TrkA_C; pfam02080 885276012058 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 885276012059 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 885276012060 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 885276012061 putative dimer interface [polypeptide binding]; other site 885276012062 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 885276012063 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 885276012064 putative dimer interface [polypeptide binding]; other site 885276012065 hypothetical protein; Provisional; Region: PRK11616 885276012066 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 885276012067 putative oxidoreductase; Provisional; Region: PRK11445 885276012068 hypothetical protein; Provisional; Region: PRK07236 885276012069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012070 D-galactonate transporter; Region: 2A0114; TIGR00893 885276012071 putative substrate translocation pore; other site 885276012072 galactonate dehydratase; Provisional; Region: PRK14017 885276012073 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 885276012074 putative active site pocket [active] 885276012075 putative metal binding site [ion binding]; other site 885276012076 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 885276012077 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 885276012078 active site 885276012079 intersubunit interface [polypeptide binding]; other site 885276012080 catalytic residue [active] 885276012081 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 885276012082 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 885276012083 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885276012084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276012085 DNA-binding site [nucleotide binding]; DNA binding site 885276012086 FCD domain; Region: FCD; pfam07729 885276012087 hypothetical protein; Provisional; Region: PRK10215 885276012088 sugar phosphate phosphatase; Provisional; Region: PRK10513 885276012089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012090 active site 885276012091 motif I; other site 885276012092 motif II; other site 885276012093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012094 hypothetical protein; Provisional; Region: PRK11426 885276012095 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 885276012096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276012097 Mg2+ binding site [ion binding]; other site 885276012098 G-X-G motif; other site 885276012099 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 885276012100 anchoring element; other site 885276012101 dimer interface [polypeptide binding]; other site 885276012102 ATP binding site [chemical binding]; other site 885276012103 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 885276012104 active site 885276012105 putative metal-binding site [ion binding]; other site 885276012106 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 885276012107 recF protein; Region: recf; TIGR00611 885276012108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276012109 Walker A/P-loop; other site 885276012110 ATP binding site [chemical binding]; other site 885276012111 Q-loop/lid; other site 885276012112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276012113 ABC transporter signature motif; other site 885276012114 Walker B; other site 885276012115 D-loop; other site 885276012116 H-loop/switch region; other site 885276012117 DNA polymerase III subunit beta; Validated; Region: PRK05643 885276012118 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 885276012119 putative DNA binding surface [nucleotide binding]; other site 885276012120 dimer interface [polypeptide binding]; other site 885276012121 beta-clamp/clamp loader binding surface; other site 885276012122 beta-clamp/translesion DNA polymerase binding surface; other site 885276012123 DnaA N-terminal domain; Region: DnaA_N; pfam11638 885276012124 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 885276012125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276012126 Walker A motif; other site 885276012127 ATP binding site [chemical binding]; other site 885276012128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 885276012129 Walker B motif; other site 885276012130 arginine finger; other site 885276012131 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 885276012132 DnaA box-binding interface [nucleotide binding]; other site 885276012133 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 885276012134 ribonuclease P; Reviewed; Region: rnpA; PRK01732 885276012135 membrane protein insertase; Provisional; Region: PRK01318 885276012136 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 885276012137 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 885276012138 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 885276012139 trmE is a tRNA modification GTPase; Region: trmE; cd04164 885276012140 G1 box; other site 885276012141 GTP/Mg2+ binding site [chemical binding]; other site 885276012142 Switch I region; other site 885276012143 G2 box; other site 885276012144 Switch II region; other site 885276012145 G3 box; other site 885276012146 G4 box; other site 885276012147 G5 box; other site 885276012148 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 885276012149 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 885276012150 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 885276012151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 885276012152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 885276012153 catalytic residue [active] 885276012154 tryptophan permease TnaB; Provisional; Region: PRK09664 885276012155 aromatic amino acid transport protein; Region: araaP; TIGR00837 885276012156 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 885276012157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012158 putative substrate translocation pore; other site 885276012159 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 885276012160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276012161 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 885276012162 substrate binding pocket [chemical binding]; other site 885276012163 dimerization interface [polypeptide binding]; other site 885276012164 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 885276012165 Predicted flavoprotein [General function prediction only]; Region: COG0431 885276012166 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 885276012167 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885276012168 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 885276012169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012170 active site 885276012171 motif I; other site 885276012172 motif II; other site 885276012173 putative inner membrane protein; Provisional; Region: PRK09823 885276012174 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 885276012175 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 885276012176 active site 885276012177 trimer interface [polypeptide binding]; other site 885276012178 allosteric site; other site 885276012179 active site lid [active] 885276012180 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 885276012181 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 885276012182 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 885276012183 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 885276012184 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 885276012185 trimer interface; other site 885276012186 sugar binding site [chemical binding]; other site 885276012187 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 885276012188 beta-galactosidase; Region: BGL; TIGR03356 885276012189 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 885276012190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276012191 active site turn [active] 885276012192 phosphorylation site [posttranslational modification] 885276012193 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276012194 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 885276012195 HPr interaction site; other site 885276012196 glycerol kinase (GK) interaction site [polypeptide binding]; other site 885276012197 active site 885276012198 phosphorylation site [posttranslational modification] 885276012199 transcriptional antiterminator BglG; Provisional; Region: PRK09772 885276012200 CAT RNA binding domain; Region: CAT_RBD; pfam03123 885276012201 PRD domain; Region: PRD; pfam00874 885276012202 PRD domain; Region: PRD; pfam00874 885276012203 transcriptional regulator PhoU; Provisional; Region: PRK11115 885276012204 PhoU domain; Region: PhoU; pfam01895 885276012205 PhoU domain; Region: PhoU; pfam01895 885276012206 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 885276012207 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 885276012208 Walker A/P-loop; other site 885276012209 ATP binding site [chemical binding]; other site 885276012210 Q-loop/lid; other site 885276012211 ABC transporter signature motif; other site 885276012212 Walker B; other site 885276012213 D-loop; other site 885276012214 H-loop/switch region; other site 885276012215 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 885276012216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276012217 dimer interface [polypeptide binding]; other site 885276012218 conserved gate region; other site 885276012219 putative PBP binding loops; other site 885276012220 ABC-ATPase subunit interface; other site 885276012221 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 885276012222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276012223 dimer interface [polypeptide binding]; other site 885276012224 conserved gate region; other site 885276012225 putative PBP binding loops; other site 885276012226 ABC-ATPase subunit interface; other site 885276012227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276012228 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 885276012229 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 885276012230 glutaminase active site [active] 885276012231 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 885276012232 dimer interface [polypeptide binding]; other site 885276012233 active site 885276012234 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 885276012235 dimer interface [polypeptide binding]; other site 885276012236 active site 885276012237 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 885276012238 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 885276012239 Substrate binding site; other site 885276012240 Mg++ binding site; other site 885276012241 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 885276012242 active site 885276012243 substrate binding site [chemical binding]; other site 885276012244 CoA binding site [chemical binding]; other site 885276012245 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 885276012246 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 885276012247 gamma subunit interface [polypeptide binding]; other site 885276012248 epsilon subunit interface [polypeptide binding]; other site 885276012249 LBP interface [polypeptide binding]; other site 885276012250 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 885276012251 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 885276012252 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 885276012253 alpha subunit interaction interface [polypeptide binding]; other site 885276012254 Walker A motif; other site 885276012255 ATP binding site [chemical binding]; other site 885276012256 Walker B motif; other site 885276012257 inhibitor binding site; inhibition site 885276012258 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 885276012259 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 885276012260 core domain interface [polypeptide binding]; other site 885276012261 delta subunit interface [polypeptide binding]; other site 885276012262 epsilon subunit interface [polypeptide binding]; other site 885276012263 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 885276012264 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 885276012265 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 885276012266 beta subunit interaction interface [polypeptide binding]; other site 885276012267 Walker A motif; other site 885276012268 ATP binding site [chemical binding]; other site 885276012269 Walker B motif; other site 885276012270 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 885276012271 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 885276012272 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 885276012273 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 885276012274 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 885276012275 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 885276012276 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 885276012277 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 885276012278 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 885276012279 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 885276012280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276012281 S-adenosylmethionine binding site [chemical binding]; other site 885276012282 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 885276012283 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 885276012284 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 885276012285 FMN-binding protein MioC; Provisional; Region: PRK09004 885276012286 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 885276012287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276012288 putative DNA binding site [nucleotide binding]; other site 885276012289 putative Zn2+ binding site [ion binding]; other site 885276012290 AsnC family; Region: AsnC_trans_reg; pfam01037 885276012291 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 885276012292 dimer interface [polypeptide binding]; other site 885276012293 active site 885276012294 hypothetical protein; Provisional; Region: yieM; PRK10997 885276012295 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 885276012296 metal ion-dependent adhesion site (MIDAS); other site 885276012297 regulatory ATPase RavA; Provisional; Region: PRK13531 885276012298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276012299 Walker A motif; other site 885276012300 ATP binding site [chemical binding]; other site 885276012301 Walker B motif; other site 885276012302 arginine finger; other site 885276012303 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 885276012304 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 885276012305 potassium uptake protein; Region: kup; TIGR00794 885276012306 D-ribose pyranase; Provisional; Region: PRK11797 885276012307 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 885276012308 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276012309 Walker A/P-loop; other site 885276012310 ATP binding site [chemical binding]; other site 885276012311 Q-loop/lid; other site 885276012312 ABC transporter signature motif; other site 885276012313 Walker B; other site 885276012314 D-loop; other site 885276012315 H-loop/switch region; other site 885276012316 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276012317 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276012318 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276012319 TM-ABC transporter signature motif; other site 885276012320 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 885276012321 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 885276012322 ligand binding site [chemical binding]; other site 885276012323 dimerization interface [polypeptide binding]; other site 885276012324 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 885276012325 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276012326 substrate binding site [chemical binding]; other site 885276012327 dimer interface [polypeptide binding]; other site 885276012328 ATP binding site [chemical binding]; other site 885276012329 transcriptional repressor RbsR; Provisional; Region: PRK10423 885276012330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276012331 DNA binding site [nucleotide binding] 885276012332 domain linker motif; other site 885276012333 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 885276012334 dimerization interface [polypeptide binding]; other site 885276012335 ligand binding site [chemical binding]; other site 885276012336 putative transporter; Provisional; Region: PRK10504 885276012337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012338 putative substrate translocation pore; other site 885276012339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012340 Transcriptional regulators [Transcription]; Region: FadR; COG2186 885276012341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276012342 DNA-binding site [nucleotide binding]; DNA binding site 885276012343 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276012344 transcriptional regulator HdfR; Provisional; Region: PRK03601 885276012345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276012346 LysR substrate binding domain; Region: LysR_substrate; pfam03466 885276012347 dimerization interface [polypeptide binding]; other site 885276012348 hypothetical protein; Provisional; Region: PRK11027 885276012349 putative ATP-dependent protease; Provisional; Region: PRK09862 885276012350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 885276012351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276012352 Walker A motif; other site 885276012353 ATP binding site [chemical binding]; other site 885276012354 Walker B motif; other site 885276012355 arginine finger; other site 885276012356 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 885276012357 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 885276012358 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 885276012359 PYR/PP interface [polypeptide binding]; other site 885276012360 dimer interface [polypeptide binding]; other site 885276012361 TPP binding site [chemical binding]; other site 885276012362 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 885276012363 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 885276012364 TPP-binding site [chemical binding]; other site 885276012365 dimer interface [polypeptide binding]; other site 885276012366 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 885276012367 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 885276012368 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 885276012369 homodimer interface [polypeptide binding]; other site 885276012370 substrate-cofactor binding pocket; other site 885276012371 catalytic residue [active] 885276012372 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 885276012373 threonine dehydratase; Reviewed; Region: PRK09224 885276012374 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 885276012375 tetramer interface [polypeptide binding]; other site 885276012376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276012377 catalytic residue [active] 885276012378 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 885276012379 putative Ile/Val binding site [chemical binding]; other site 885276012380 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 885276012381 putative Ile/Val binding site [chemical binding]; other site 885276012382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276012383 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 885276012384 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 885276012385 putative dimerization interface [polypeptide binding]; other site 885276012386 ketol-acid reductoisomerase; Validated; Region: PRK05225 885276012387 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 885276012388 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 885276012389 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 885276012390 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 885276012391 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 885276012392 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 885276012393 Part of AAA domain; Region: AAA_19; pfam13245 885276012394 Family description; Region: UvrD_C_2; pfam13538 885276012395 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 885276012396 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 885276012397 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 885276012398 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 885276012399 ATP binding site [chemical binding]; other site 885276012400 Mg++ binding site [ion binding]; other site 885276012401 motif III; other site 885276012402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276012403 nucleotide binding region [chemical binding]; other site 885276012404 ATP-binding site [chemical binding]; other site 885276012405 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 885276012406 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 885276012407 catalytic residues [active] 885276012408 transcription termination factor Rho; Provisional; Region: rho; PRK09376 885276012409 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 885276012410 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 885276012411 RNA binding site [nucleotide binding]; other site 885276012412 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 885276012413 multimer interface [polypeptide binding]; other site 885276012414 Walker A motif; other site 885276012415 ATP binding site [chemical binding]; other site 885276012416 Walker B motif; other site 885276012417 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 885276012418 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 885276012419 Mg++ binding site [ion binding]; other site 885276012420 putative catalytic motif [active] 885276012421 substrate binding site [chemical binding]; other site 885276012422 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 885276012423 Chain length determinant protein; Region: Wzz; pfam02706 885276012424 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 885276012425 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 885276012426 active site 885276012427 homodimer interface [polypeptide binding]; other site 885276012428 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 885276012429 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 885276012430 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 885276012431 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 885276012432 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 885276012433 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 885276012434 NAD binding site [chemical binding]; other site 885276012435 substrate binding site [chemical binding]; other site 885276012436 homodimer interface [polypeptide binding]; other site 885276012437 active site 885276012438 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 885276012439 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 885276012440 substrate binding site; other site 885276012441 tetramer interface; other site 885276012442 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 885276012443 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 885276012444 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 885276012445 inhibitor-cofactor binding pocket; inhibition site 885276012446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276012447 catalytic residue [active] 885276012448 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 885276012449 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 885276012450 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 885276012451 putative common antigen polymerase; Provisional; Region: PRK02975 885276012452 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 885276012453 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 885276012454 putative transport protein YifK; Provisional; Region: PRK10746 885276012455 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 885276012456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276012457 FeS/SAM binding site; other site 885276012458 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 885276012459 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 885276012460 Sulfatase; Region: Sulfatase; pfam00884 885276012461 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 885276012462 HemY protein N-terminus; Region: HemY_N; pfam07219 885276012463 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 885276012464 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 885276012465 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 885276012466 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 885276012467 active site 885276012468 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 885276012469 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 885276012470 domain interfaces; other site 885276012471 active site 885276012472 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 885276012473 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 885276012474 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 885276012475 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 885276012476 putative iron binding site [ion binding]; other site 885276012477 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 885276012478 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 885276012479 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 885276012480 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 885276012481 hypothetical protein; Provisional; Region: PRK10963 885276012482 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 885276012483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 885276012484 active site 885276012485 DNA binding site [nucleotide binding] 885276012486 Int/Topo IB signature motif; other site 885276012487 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 885276012488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012489 motif II; other site 885276012490 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 885276012491 Part of AAA domain; Region: AAA_19; pfam13245 885276012492 Family description; Region: UvrD_C_2; pfam13538 885276012493 Uncharacterized conserved protein [Function unknown]; Region: COG1912 885276012494 Predicted periplasmic protein [Function unknown]; Region: COG3698 885276012495 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 885276012496 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 885276012497 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 885276012498 Cl binding site [ion binding]; other site 885276012499 oligomer interface [polypeptide binding]; other site 885276012500 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 885276012501 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 885276012502 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 885276012503 EamA-like transporter family; Region: EamA; cl17759 885276012504 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 885276012505 CoenzymeA binding site [chemical binding]; other site 885276012506 subunit interaction site [polypeptide binding]; other site 885276012507 PHB binding site; other site 885276012508 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 885276012509 dimerization interface [polypeptide binding]; other site 885276012510 substrate binding site [chemical binding]; other site 885276012511 active site 885276012512 calcium binding site [ion binding]; other site 885276012513 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 885276012514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276012515 ATP binding site [chemical binding]; other site 885276012516 putative Mg++ binding site [ion binding]; other site 885276012517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276012518 nucleotide binding region [chemical binding]; other site 885276012519 ATP-binding site [chemical binding]; other site 885276012520 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 885276012521 Helicase and RNase D C-terminal; Region: HRDC; smart00341 885276012522 threonine efflux system; Provisional; Region: PRK10229 885276012523 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 885276012524 lysophospholipase L2; Provisional; Region: PRK10749 885276012525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885276012526 putative hydrolase; Provisional; Region: PRK10976 885276012527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012528 active site 885276012529 motif I; other site 885276012530 motif II; other site 885276012531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012532 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 885276012533 EamA-like transporter family; Region: EamA; pfam00892 885276012534 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 885276012535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276012536 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 885276012537 putative dimerization interface [polypeptide binding]; other site 885276012538 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 885276012539 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 885276012540 THF binding site; other site 885276012541 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 885276012542 substrate binding site [chemical binding]; other site 885276012543 THF binding site; other site 885276012544 zinc-binding site [ion binding]; other site 885276012545 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 885276012546 tetramer interface [polypeptide binding]; other site 885276012547 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 885276012548 active site 885276012549 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 885276012550 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276012551 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276012552 active site turn [active] 885276012553 phosphorylation site [posttranslational modification] 885276012554 transketolase; Reviewed; Region: PRK12753 885276012555 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 885276012556 TPP-binding site [chemical binding]; other site 885276012557 dimer interface [polypeptide binding]; other site 885276012558 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 885276012559 PYR/PP interface [polypeptide binding]; other site 885276012560 dimer interface [polypeptide binding]; other site 885276012561 TPP binding site [chemical binding]; other site 885276012562 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 885276012563 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885276012564 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 885276012565 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885276012566 putative active site [active] 885276012567 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 885276012568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276012569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 885276012570 dimerization interface [polypeptide binding]; other site 885276012571 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 885276012572 Na binding site [ion binding]; other site 885276012573 allophanate hydrolase; Provisional; Region: PRK08186 885276012574 carbamate kinase; Reviewed; Region: PRK12686 885276012575 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885276012576 putative substrate binding site [chemical binding]; other site 885276012577 nucleotide binding site [chemical binding]; other site 885276012578 nucleotide binding site [chemical binding]; other site 885276012579 homodimer interface [polypeptide binding]; other site 885276012580 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 885276012581 CoA binding domain; Region: CoA_binding; pfam02629 885276012582 CoA-ligase; Region: Ligase_CoA; pfam00549 885276012583 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 885276012584 Isochorismatase family; Region: Isochorismatase; pfam00857 885276012585 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 885276012586 catalytic triad [active] 885276012587 conserved cis-peptide bond; other site 885276012588 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 885276012589 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 885276012590 uridine phosphorylase; Provisional; Region: PRK11178 885276012591 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 885276012592 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 885276012593 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 885276012594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 885276012595 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 885276012596 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 885276012597 active site 885276012598 intersubunit interface [polypeptide binding]; other site 885276012599 catalytic residue [active] 885276012600 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 885276012601 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 885276012602 Transcriptional regulator [Transcription]; Region: IclR; COG1414 885276012603 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885276012604 Bacterial transcriptional regulator; Region: IclR; pfam01614 885276012605 DNA recombination protein RmuC; Provisional; Region: PRK10361 885276012606 RmuC family; Region: RmuC; pfam02646 885276012607 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 885276012608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276012609 S-adenosylmethionine binding site [chemical binding]; other site 885276012610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 885276012611 SCP-2 sterol transfer family; Region: SCP2; pfam02036 885276012612 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 885276012613 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 885276012614 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 885276012615 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 885276012616 sec-independent translocase; Provisional; Region: PRK01770 885276012617 sec-independent translocase; Provisional; Region: tatB; PRK00404 885276012618 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 885276012619 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 885276012620 active site 885276012621 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 885276012622 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 885276012623 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 885276012624 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 885276012625 FMN reductase; Validated; Region: fre; PRK08051 885276012626 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 885276012627 FAD binding pocket [chemical binding]; other site 885276012628 FAD binding motif [chemical binding]; other site 885276012629 phosphate binding motif [ion binding]; other site 885276012630 beta-alpha-beta structure motif; other site 885276012631 NAD binding pocket [chemical binding]; other site 885276012632 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 885276012633 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 885276012634 dimer interface [polypeptide binding]; other site 885276012635 active site 885276012636 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 885276012637 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885276012638 substrate binding site [chemical binding]; other site 885276012639 oxyanion hole (OAH) forming residues; other site 885276012640 trimer interface [polypeptide binding]; other site 885276012641 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 885276012642 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885276012643 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 885276012644 proline dipeptidase; Provisional; Region: PRK13607 885276012645 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 885276012646 active site 885276012647 hypothetical protein; Provisional; Region: PRK11568 885276012648 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 885276012649 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 885276012650 potassium transporter; Provisional; Region: PRK10750 885276012651 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 885276012652 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 885276012653 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 885276012654 Walker A motif; other site 885276012655 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 885276012656 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 885276012657 GTP binding site; other site 885276012658 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 885276012659 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 885276012660 serine/threonine protein kinase; Provisional; Region: PRK11768 885276012661 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 885276012662 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 885276012663 catalytic residues [active] 885276012664 hinge region; other site 885276012665 alpha helical domain; other site 885276012666 hypothetical protein; Provisional; Region: PRK11367 885276012667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 885276012668 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 885276012669 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 885276012670 putative acyl-acceptor binding pocket; other site 885276012671 DNA polymerase I; Provisional; Region: PRK05755 885276012672 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 885276012673 active site 885276012674 metal binding site 1 [ion binding]; metal-binding site 885276012675 putative 5' ssDNA interaction site; other site 885276012676 metal binding site 3; metal-binding site 885276012677 metal binding site 2 [ion binding]; metal-binding site 885276012678 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 885276012679 putative DNA binding site [nucleotide binding]; other site 885276012680 putative metal binding site [ion binding]; other site 885276012681 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 885276012682 active site 885276012683 catalytic site [active] 885276012684 substrate binding site [chemical binding]; other site 885276012685 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 885276012686 active site 885276012687 DNA binding site [nucleotide binding] 885276012688 catalytic site [active] 885276012689 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 885276012690 G1 box; other site 885276012691 GTP/Mg2+ binding site [chemical binding]; other site 885276012692 Switch I region; other site 885276012693 G2 box; other site 885276012694 G3 box; other site 885276012695 Switch II region; other site 885276012696 G4 box; other site 885276012697 G5 box; other site 885276012698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 885276012699 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 885276012700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276012701 FeS/SAM binding site; other site 885276012702 HemN C-terminal domain; Region: HemN_C; pfam06969 885276012703 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 885276012704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276012705 active site 885276012706 phosphorylation site [posttranslational modification] 885276012707 intermolecular recognition site; other site 885276012708 dimerization interface [polypeptide binding]; other site 885276012709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276012710 Walker A motif; other site 885276012711 ATP binding site [chemical binding]; other site 885276012712 Walker B motif; other site 885276012713 arginine finger; other site 885276012714 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276012715 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 885276012716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 885276012717 putative active site [active] 885276012718 heme pocket [chemical binding]; other site 885276012719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276012720 dimer interface [polypeptide binding]; other site 885276012721 phosphorylation site [posttranslational modification] 885276012722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276012723 ATP binding site [chemical binding]; other site 885276012724 Mg2+ binding site [ion binding]; other site 885276012725 G-X-G motif; other site 885276012726 glutamine synthetase; Provisional; Region: glnA; PRK09469 885276012727 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 885276012728 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 885276012729 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 885276012730 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 885276012731 G1 box; other site 885276012732 putative GEF interaction site [polypeptide binding]; other site 885276012733 GTP/Mg2+ binding site [chemical binding]; other site 885276012734 Switch I region; other site 885276012735 G2 box; other site 885276012736 G3 box; other site 885276012737 Switch II region; other site 885276012738 G4 box; other site 885276012739 G5 box; other site 885276012740 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 885276012741 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 885276012742 transcriptional regulator protein; Region: phnR; TIGR03337 885276012743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276012744 DNA-binding site [nucleotide binding]; DNA binding site 885276012745 UTRA domain; Region: UTRA; pfam07702 885276012746 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 885276012747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012748 putative substrate translocation pore; other site 885276012749 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 885276012750 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 885276012751 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276012752 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276012753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 885276012754 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 885276012755 substrate binding site [chemical binding]; other site 885276012756 ATP binding site [chemical binding]; other site 885276012757 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 885276012758 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 885276012759 Class I aldolases; Region: Aldolase_Class_I; cl17187 885276012760 catalytic residue [active] 885276012761 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 885276012762 putative oxidoreductase; Provisional; Region: PRK10083 885276012763 NAD(P) binding site [chemical binding]; other site 885276012764 benzoate transport; Region: 2A0115; TIGR00895 885276012765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012767 shikimate transporter; Provisional; Region: PRK09952 885276012768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276012769 putative substrate translocation pore; other site 885276012770 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 885276012771 active site 885276012772 catalytic residues [active] 885276012773 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 885276012774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276012775 motif II; other site 885276012776 hypothetical protein; Reviewed; Region: PRK01637 885276012777 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 885276012778 putative active site [active] 885276012779 dimerization interface [polypeptide binding]; other site 885276012780 putative tRNAtyr binding site [nucleotide binding]; other site 885276012781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276012782 Coenzyme A binding pocket [chemical binding]; other site 885276012783 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 885276012784 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 885276012785 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 885276012786 substrate binding pocket [chemical binding]; other site 885276012787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276012788 non-specific DNA binding site [nucleotide binding]; other site 885276012789 salt bridge; other site 885276012790 sequence-specific DNA binding site [nucleotide binding]; other site 885276012791 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 885276012792 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 885276012793 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 885276012794 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 885276012795 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 885276012796 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 885276012797 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 885276012798 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 885276012799 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 885276012800 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 885276012801 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 885276012802 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885276012803 intersubunit interface [polypeptide binding]; other site 885276012804 active site 885276012805 Zn2+ binding site [ion binding]; other site 885276012806 L-rhamnose isomerase; Provisional; Region: PRK01076 885276012807 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 885276012808 N- and C-terminal domain interface [polypeptide binding]; other site 885276012809 active site 885276012810 putative catalytic site [active] 885276012811 metal binding site [ion binding]; metal-binding site 885276012812 ATP binding site [chemical binding]; other site 885276012813 rhamnulokinase; Provisional; Region: rhaB; PRK10640 885276012814 carbohydrate binding site [chemical binding]; other site 885276012815 transcriptional activator RhaS; Provisional; Region: PRK13503 885276012816 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885276012817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276012818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276012819 transcriptional activator RhaR; Provisional; Region: PRK13500 885276012820 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 885276012821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276012822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276012823 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 885276012824 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 885276012825 superoxide dismutase; Provisional; Region: PRK10925 885276012826 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 885276012827 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 885276012828 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 885276012829 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 885276012830 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 885276012831 MOSC domain; Region: MOSC; pfam03473 885276012832 3-alpha domain; Region: 3-alpha; pfam03475 885276012833 two-component sensor protein; Provisional; Region: cpxA; PRK09470 885276012834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276012835 dimerization interface [polypeptide binding]; other site 885276012836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276012837 dimer interface [polypeptide binding]; other site 885276012838 phosphorylation site [posttranslational modification] 885276012839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276012840 ATP binding site [chemical binding]; other site 885276012841 Mg2+ binding site [ion binding]; other site 885276012842 G-X-G motif; other site 885276012843 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 885276012844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276012845 active site 885276012846 intermolecular recognition site; other site 885276012847 dimerization interface [polypeptide binding]; other site 885276012848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276012849 DNA binding site [nucleotide binding] 885276012850 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 885276012851 dimer interface [polypeptide binding]; other site 885276012852 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 885276012853 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 885276012854 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 885276012855 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 885276012856 active site 885276012857 ADP/pyrophosphate binding site [chemical binding]; other site 885276012858 dimerization interface [polypeptide binding]; other site 885276012859 allosteric effector site; other site 885276012860 fructose-1,6-bisphosphate binding site; other site 885276012861 sulfate transporter subunit; Provisional; Region: PRK10752 885276012862 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 885276012863 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 885276012864 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 885276012865 triosephosphate isomerase; Provisional; Region: PRK14567 885276012866 substrate binding site [chemical binding]; other site 885276012867 dimer interface [polypeptide binding]; other site 885276012868 catalytic triad [active] 885276012869 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 885276012870 Predicted membrane protein [Function unknown]; Region: COG3152 885276012871 hypothetical protein; Provisional; Region: PRK09981 885276012872 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 885276012873 Ligand Binding Site [chemical binding]; other site 885276012874 ferredoxin-NADP reductase; Provisional; Region: PRK10926 885276012875 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 885276012876 FAD binding pocket [chemical binding]; other site 885276012877 FAD binding motif [chemical binding]; other site 885276012878 phosphate binding motif [ion binding]; other site 885276012879 beta-alpha-beta structure motif; other site 885276012880 NAD binding pocket [chemical binding]; other site 885276012881 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 885276012882 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 885276012883 putative active site [active] 885276012884 glycerol kinase; Provisional; Region: glpK; PRK00047 885276012885 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 885276012886 N- and C-terminal domain interface [polypeptide binding]; other site 885276012887 active site 885276012888 MgATP binding site [chemical binding]; other site 885276012889 catalytic site [active] 885276012890 metal binding site [ion binding]; metal-binding site 885276012891 glycerol binding site [chemical binding]; other site 885276012892 homotetramer interface [polypeptide binding]; other site 885276012893 homodimer interface [polypeptide binding]; other site 885276012894 FBP binding site [chemical binding]; other site 885276012895 protein IIAGlc interface [polypeptide binding]; other site 885276012896 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 885276012897 amphipathic channel; other site 885276012898 Asn-Pro-Ala signature motifs; other site 885276012899 septal ring assembly protein ZapB; Provisional; Region: PRK15422 885276012900 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 885276012901 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 885276012902 UbiA prenyltransferase family; Region: UbiA; pfam01040 885276012903 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 885276012904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276012905 Walker A motif; other site 885276012906 ATP binding site [chemical binding]; other site 885276012907 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 885276012908 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 885276012909 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 885276012910 active site 885276012911 HslU subunit interaction site [polypeptide binding]; other site 885276012912 essential cell division protein FtsN; Provisional; Region: PRK10927 885276012913 cell division protein FtsN; Provisional; Region: PRK12757 885276012914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276012915 DNA binding site [nucleotide binding] 885276012916 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 885276012917 domain linker motif; other site 885276012918 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 885276012919 dimerization interface [polypeptide binding]; other site 885276012920 ligand binding site [chemical binding]; other site 885276012921 primosome assembly protein PriA; Validated; Region: PRK05580 885276012922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276012923 ATP binding site [chemical binding]; other site 885276012924 putative Mg++ binding site [ion binding]; other site 885276012925 helicase superfamily c-terminal domain; Region: HELICc; smart00490 885276012926 ATP-binding site [chemical binding]; other site 885276012927 hypothetical protein; Provisional; Region: PRK10030 885276012928 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 885276012929 dimerization interface [polypeptide binding]; other site 885276012930 DNA binding site [nucleotide binding] 885276012931 corepressor binding sites; other site 885276012932 cystathionine gamma-synthase; Provisional; Region: PRK08045 885276012933 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 885276012934 homodimer interface [polypeptide binding]; other site 885276012935 substrate-cofactor binding pocket; other site 885276012936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276012937 catalytic residue [active] 885276012938 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 885276012939 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 885276012940 putative catalytic residues [active] 885276012941 putative nucleotide binding site [chemical binding]; other site 885276012942 putative aspartate binding site [chemical binding]; other site 885276012943 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 885276012944 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 885276012945 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 885276012946 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 885276012947 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 885276012948 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 885276012949 active site 885276012950 metal binding site [ion binding]; metal-binding site 885276012951 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885276012952 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 885276012953 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 885276012954 active site 885276012955 metal binding site [ion binding]; metal-binding site 885276012956 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885276012957 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 885276012958 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 885276012959 active site 885276012960 metal binding site [ion binding]; metal-binding site 885276012961 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885276012962 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 885276012963 FAD binding site [chemical binding]; other site 885276012964 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 885276012965 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 885276012966 heme binding site [chemical binding]; other site 885276012967 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 885276012968 EamA-like transporter family; Region: EamA; pfam00892 885276012969 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 885276012970 EamA-like transporter family; Region: EamA; pfam00892 885276012971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 885276012972 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 885276012973 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 885276012974 dimer interface [polypeptide binding]; other site 885276012975 active site 885276012976 metal binding site [ion binding]; metal-binding site 885276012977 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 885276012978 active site 885276012979 intersubunit interactions; other site 885276012980 catalytic residue [active] 885276012981 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 885276012982 dimerization domain swap beta strand [polypeptide binding]; other site 885276012983 regulatory protein interface [polypeptide binding]; other site 885276012984 active site 885276012985 regulatory phosphorylation site [posttranslational modification]; other site 885276012986 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 885276012987 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 885276012988 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 885276012989 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885276012990 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276012991 active site 885276012992 phosphorylation site [posttranslational modification] 885276012993 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 885276012994 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 885276012995 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885276012996 active site 885276012997 P-loop; other site 885276012998 phosphorylation site [posttranslational modification] 885276012999 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 885276013000 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 885276013001 dimer interface [polypeptide binding]; other site 885276013002 active site 885276013003 glycine loop; other site 885276013004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276013005 FeS/SAM binding site; other site 885276013006 pyruvate formate lyase II activase; Provisional; Region: PRK10076 885276013007 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 885276013008 active site 885276013009 P-loop; other site 885276013010 phosphorylation site [posttranslational modification] 885276013011 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276013012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276013013 hypothetical protein; Provisional; Region: PRK10649 885276013014 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 885276013015 Sulfatase; Region: Sulfatase; pfam00884 885276013016 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 885276013017 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 885276013018 acetylornithine deacetylase; Provisional; Region: PRK05111 885276013019 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 885276013020 metal binding site [ion binding]; metal-binding site 885276013021 putative dimer interface [polypeptide binding]; other site 885276013022 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 885276013023 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 885276013024 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 885276013025 nucleotide binding site [chemical binding]; other site 885276013026 N-acetyl-L-glutamate binding site [chemical binding]; other site 885276013027 argininosuccinate lyase; Provisional; Region: PRK04833 885276013028 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 885276013029 active sites [active] 885276013030 tetramer interface [polypeptide binding]; other site 885276013031 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 885276013032 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 885276013033 putative active site pocket [active] 885276013034 putative metal binding site [ion binding]; other site 885276013035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276013036 D-galactonate transporter; Region: 2A0114; TIGR00893 885276013037 putative substrate translocation pore; other site 885276013038 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 885276013039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276013040 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 885276013041 dimerization interface [polypeptide binding]; other site 885276013042 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 885276013043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276013044 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885276013045 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 885276013046 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 885276013047 metal binding site [ion binding]; metal-binding site 885276013048 putative dimer interface [polypeptide binding]; other site 885276013049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276013050 metabolite-proton symporter; Region: 2A0106; TIGR00883 885276013051 putative substrate translocation pore; other site 885276013052 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 885276013053 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276013054 hypothetical protein; Provisional; Region: PRK11056 885276013055 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 885276013056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276013057 S-adenosylmethionine binding site [chemical binding]; other site 885276013058 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 885276013059 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 885276013060 N-terminal plug; other site 885276013061 ligand-binding site [chemical binding]; other site 885276013062 glutamate racemase; Provisional; Region: PRK00865 885276013063 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 885276013064 FAD binding domain; Region: FAD_binding_4; pfam01565 885276013065 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 885276013066 Biotin operon repressor [Transcription]; Region: BirA; COG1654 885276013067 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 885276013068 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 885276013069 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 885276013070 pantothenate kinase; Provisional; Region: PRK05439 885276013071 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 885276013072 ATP-binding site [chemical binding]; other site 885276013073 CoA-binding site [chemical binding]; other site 885276013074 Mg2+-binding site [ion binding]; other site 885276013075 elongation factor Tu; Reviewed; Region: PRK00049 885276013076 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 885276013077 G1 box; other site 885276013078 GEF interaction site [polypeptide binding]; other site 885276013079 GTP/Mg2+ binding site [chemical binding]; other site 885276013080 Switch I region; other site 885276013081 G2 box; other site 885276013082 G3 box; other site 885276013083 Switch II region; other site 885276013084 G4 box; other site 885276013085 G5 box; other site 885276013086 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 885276013087 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 885276013088 Antibiotic Binding Site [chemical binding]; other site 885276013089 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 885276013090 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 885276013091 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 885276013092 putative homodimer interface [polypeptide binding]; other site 885276013093 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 885276013094 heterodimer interface [polypeptide binding]; other site 885276013095 homodimer interface [polypeptide binding]; other site 885276013096 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 885276013097 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 885276013098 23S rRNA interface [nucleotide binding]; other site 885276013099 L7/L12 interface [polypeptide binding]; other site 885276013100 putative thiostrepton binding site; other site 885276013101 L25 interface [polypeptide binding]; other site 885276013102 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 885276013103 mRNA/rRNA interface [nucleotide binding]; other site 885276013104 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 885276013105 23S rRNA interface [nucleotide binding]; other site 885276013106 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 885276013107 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 885276013108 core dimer interface [polypeptide binding]; other site 885276013109 peripheral dimer interface [polypeptide binding]; other site 885276013110 L10 interface [polypeptide binding]; other site 885276013111 L11 interface [polypeptide binding]; other site 885276013112 putative EF-Tu interaction site [polypeptide binding]; other site 885276013113 putative EF-G interaction site [polypeptide binding]; other site 885276013114 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 885276013115 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 885276013116 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 885276013117 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 885276013118 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 885276013119 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 885276013120 RPB3 interaction site [polypeptide binding]; other site 885276013121 RPB1 interaction site [polypeptide binding]; other site 885276013122 RPB11 interaction site [polypeptide binding]; other site 885276013123 RPB10 interaction site [polypeptide binding]; other site 885276013124 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 885276013125 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 885276013126 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 885276013127 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 885276013128 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 885276013129 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 885276013130 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 885276013131 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 885276013132 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 885276013133 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 885276013134 DNA binding site [nucleotide binding] 885276013135 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 885276013136 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 885276013137 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276013138 FeS/SAM binding site; other site 885276013139 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 885276013140 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 885276013141 ThiS interaction site; other site 885276013142 putative active site [active] 885276013143 tetramer interface [polypeptide binding]; other site 885276013144 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 885276013145 thiS-thiF/thiG interaction site; other site 885276013146 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 885276013147 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 885276013148 ATP binding site [chemical binding]; other site 885276013149 substrate interface [chemical binding]; other site 885276013150 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 885276013151 thiamine phosphate binding site [chemical binding]; other site 885276013152 active site 885276013153 pyrophosphate binding site [ion binding]; other site 885276013154 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 885276013155 ThiC-associated domain; Region: ThiC-associated; pfam13667 885276013156 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 885276013157 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 885276013158 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 885276013159 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 885276013160 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 885276013161 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 885276013162 putative NADH binding site [chemical binding]; other site 885276013163 putative active site [active] 885276013164 nudix motif; other site 885276013165 putative metal binding site [ion binding]; other site 885276013166 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 885276013167 substrate binding site [chemical binding]; other site 885276013168 active site 885276013169 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 885276013170 Active_site [active] 885276013171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 885276013172 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 885276013173 IHF dimer interface [polypeptide binding]; other site 885276013174 IHF - DNA interface [nucleotide binding]; other site 885276013175 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 885276013176 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 885276013177 dimer interface [polypeptide binding]; other site 885276013178 sensor protein ZraS; Provisional; Region: PRK10364 885276013179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276013180 dimer interface [polypeptide binding]; other site 885276013181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276013182 ATP binding site [chemical binding]; other site 885276013183 Mg2+ binding site [ion binding]; other site 885276013184 G-X-G motif; other site 885276013185 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 885276013186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276013187 active site 885276013188 phosphorylation site [posttranslational modification] 885276013189 intermolecular recognition site; other site 885276013190 dimerization interface [polypeptide binding]; other site 885276013191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276013192 Walker A motif; other site 885276013193 ATP binding site [chemical binding]; other site 885276013194 Walker B motif; other site 885276013195 arginine finger; other site 885276013196 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276013197 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 885276013198 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 885276013199 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 885276013200 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 885276013201 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 885276013202 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 885276013203 purine monophosphate binding site [chemical binding]; other site 885276013204 dimer interface [polypeptide binding]; other site 885276013205 putative catalytic residues [active] 885276013206 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 885276013207 hypothetical protein; Provisional; Region: PRK10039 885276013208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 885276013209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276013210 Coenzyme A binding pocket [chemical binding]; other site 885276013211 homoserine O-succinyltransferase; Provisional; Region: PRK05368 885276013212 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 885276013213 proposed active site lysine [active] 885276013214 conserved cys residue [active] 885276013215 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 885276013216 malate synthase A; Region: malate_syn_A; TIGR01344 885276013217 active site 885276013218 isocitrate lyase; Provisional; Region: PRK15063 885276013219 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 885276013220 tetramer interface [polypeptide binding]; other site 885276013221 active site 885276013222 Mg2+/Mn2+ binding site [ion binding]; other site 885276013223 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 885276013224 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 885276013225 transcriptional repressor IclR; Provisional; Region: PRK11569 885276013226 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 885276013227 Bacterial transcriptional regulator; Region: IclR; pfam01614 885276013228 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 885276013229 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 885276013230 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 885276013231 substrate binding pocket [chemical binding]; other site 885276013232 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 885276013233 B12 binding site [chemical binding]; other site 885276013234 cobalt ligand [ion binding]; other site 885276013235 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 885276013236 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 885276013237 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 885276013238 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 885276013239 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 885276013240 active site pocket [active] 885276013241 oxyanion hole [active] 885276013242 catalytic triad [active] 885276013243 active site nucleophile [active] 885276013244 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 885276013245 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276013246 putative NAD(P) binding site [chemical binding]; other site 885276013247 catalytic Zn binding site [ion binding]; other site 885276013248 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 885276013249 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 885276013250 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 885276013251 active site 885276013252 phosphorylation site [posttranslational modification] 885276013253 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 885276013254 active pocket/dimerization site; other site 885276013255 active site 885276013256 phosphorylation site [posttranslational modification] 885276013257 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 885276013258 classical (c) SDRs; Region: SDR_c; cd05233 885276013259 NAD(P) binding site [chemical binding]; other site 885276013260 active site 885276013261 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 885276013262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 885276013263 putative DNA binding site [nucleotide binding]; other site 885276013264 putative Zn2+ binding site [ion binding]; other site 885276013265 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 885276013266 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 885276013267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 885276013268 RNA binding surface [nucleotide binding]; other site 885276013269 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 885276013270 probable active site [active] 885276013271 hypothetical protein; Provisional; Region: PRK10515 885276013272 aspartate kinase III; Validated; Region: PRK09084 885276013273 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 885276013274 nucleotide binding site [chemical binding]; other site 885276013275 substrate binding site [chemical binding]; other site 885276013276 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 885276013277 lysine allosteric regulatory site; other site 885276013278 dimer interface [polypeptide binding]; other site 885276013279 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 885276013280 dimer interface [polypeptide binding]; other site 885276013281 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 885276013282 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 885276013283 active site 885276013284 dimer interface [polypeptide binding]; other site 885276013285 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 885276013286 dimer interface [polypeptide binding]; other site 885276013287 active site 885276013288 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 885276013289 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 885276013290 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 885276013291 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 885276013292 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 885276013293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276013294 dimer interface [polypeptide binding]; other site 885276013295 conserved gate region; other site 885276013296 putative PBP binding loops; other site 885276013297 ABC-ATPase subunit interface; other site 885276013298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276013299 dimer interface [polypeptide binding]; other site 885276013300 conserved gate region; other site 885276013301 putative PBP binding loops; other site 885276013302 ABC-ATPase subunit interface; other site 885276013303 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 885276013304 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 885276013305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 885276013306 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 885276013307 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 885276013308 Walker A/P-loop; other site 885276013309 ATP binding site [chemical binding]; other site 885276013310 Q-loop/lid; other site 885276013311 ABC transporter signature motif; other site 885276013312 Walker B; other site 885276013313 D-loop; other site 885276013314 H-loop/switch region; other site 885276013315 TOBE domain; Region: TOBE_2; pfam08402 885276013316 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 885276013317 trimer interface; other site 885276013318 sugar binding site [chemical binding]; other site 885276013319 maltose regulon periplasmic protein; Provisional; Region: PRK10564 885276013320 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 885276013321 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 885276013322 UbiA prenyltransferase family; Region: UbiA; pfam01040 885276013323 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 885276013324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 885276013325 putative acyl-acceptor binding pocket; other site 885276013326 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 885276013327 LexA repressor; Validated; Region: PRK00215 885276013328 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 885276013329 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 885276013330 Catalytic site [active] 885276013331 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 885276013332 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 885276013333 hypothetical protein; Provisional; Region: PRK10428 885276013334 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 885276013335 metal binding site 2 [ion binding]; metal-binding site 885276013336 putative DNA binding helix; other site 885276013337 metal binding site 1 [ion binding]; metal-binding site 885276013338 dimer interface [polypeptide binding]; other site 885276013339 structural Zn2+ binding site [ion binding]; other site 885276013340 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 885276013341 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 885276013342 FMN binding site [chemical binding]; other site 885276013343 active site 885276013344 catalytic residues [active] 885276013345 substrate binding site [chemical binding]; other site 885276013346 phage shock protein G; Reviewed; Region: pspG; PRK09459 885276013347 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 885276013348 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 885276013349 NADP binding site [chemical binding]; other site 885276013350 dimer interface [polypeptide binding]; other site 885276013351 L-aspartate oxidase; Provisional; Region: PRK06175 885276013352 FAD binding domain; Region: FAD_binding_2; pfam00890 885276013353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276013354 metabolite-proton symporter; Region: 2A0106; TIGR00883 885276013355 putative substrate translocation pore; other site 885276013356 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 885276013357 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885276013358 substrate binding site [chemical binding]; other site 885276013359 oxyanion hole (OAH) forming residues; other site 885276013360 trimer interface [polypeptide binding]; other site 885276013361 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 885276013362 Coenzyme A transferase; Region: CoA_trans; smart00882 885276013363 Coenzyme A transferase; Region: CoA_trans; cl17247 885276013364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 885276013365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276013366 DNA binding site [nucleotide binding] 885276013367 domain linker motif; other site 885276013368 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 885276013369 putative dimerization interface [polypeptide binding]; other site 885276013370 putative ligand binding site [chemical binding]; other site 885276013371 replicative DNA helicase; Provisional; Region: PRK08006 885276013372 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 885276013373 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 885276013374 Walker A motif; other site 885276013375 ATP binding site [chemical binding]; other site 885276013376 Walker B motif; other site 885276013377 DNA binding loops [nucleotide binding] 885276013378 putative lipoprotein; Provisional; Region: PRK10533 885276013379 alanine racemase; Reviewed; Region: alr; PRK00053 885276013380 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 885276013381 active site 885276013382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 885276013383 substrate binding site [chemical binding]; other site 885276013384 catalytic residues [active] 885276013385 dimer interface [polypeptide binding]; other site 885276013386 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 885276013387 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 885276013388 active site 885276013389 (T/H)XGH motif; other site 885276013390 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 885276013391 AAA domain; Region: AAA_28; pfam13521 885276013392 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 885276013393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 885276013394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276013395 homodimer interface [polypeptide binding]; other site 885276013396 catalytic residue [active] 885276013397 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 885276013398 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 885276013399 TPP-binding site [chemical binding]; other site 885276013400 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 885276013401 dimer interface [polypeptide binding]; other site 885276013402 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 885276013403 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 885276013404 E3 interaction surface; other site 885276013405 lipoyl attachment site [posttranslational modification]; other site 885276013406 e3 binding domain; Region: E3_binding; pfam02817 885276013407 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 885276013408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 885276013409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 885276013410 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 885276013411 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 885276013412 CoA-ligase; Region: Ligase_CoA; pfam00549 885276013413 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 885276013414 CoA binding domain; Region: CoA_binding; smart00881 885276013415 CoA-ligase; Region: Ligase_CoA; pfam00549 885276013416 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 885276013417 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 885276013418 transmembrane helices; other site 885276013419 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 885276013420 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 885276013421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276013422 active site 885276013423 phosphorylation site [posttranslational modification] 885276013424 intermolecular recognition site; other site 885276013425 dimerization interface [polypeptide binding]; other site 885276013426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276013427 Walker A motif; other site 885276013428 ATP binding site [chemical binding]; other site 885276013429 Walker B motif; other site 885276013430 arginine finger; other site 885276013431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 885276013432 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 885276013433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276013434 dimer interface [polypeptide binding]; other site 885276013435 phosphorylation site [posttranslational modification] 885276013436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276013437 ATP binding site [chemical binding]; other site 885276013438 Mg2+ binding site [ion binding]; other site 885276013439 G-X-G motif; other site 885276013440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276013441 active site 885276013442 motif I; other site 885276013443 motif II; other site 885276013444 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 885276013445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 885276013446 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 885276013447 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 885276013448 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 885276013449 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 885276013450 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 885276013451 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 885276013452 dimer interface [polypeptide binding]; other site 885276013453 ssDNA binding site [nucleotide binding]; other site 885276013454 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885276013455 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 885276013456 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 885276013457 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 885276013458 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 885276013459 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 885276013460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276013461 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 885276013462 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 885276013463 DNA binding residues [nucleotide binding] 885276013464 dimer interface [polypeptide binding]; other site 885276013465 [2Fe-2S] cluster binding site [ion binding]; other site 885276013466 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 885276013467 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 885276013468 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 885276013469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 885276013470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276013471 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 885276013472 putative dimerization interface [polypeptide binding]; other site 885276013473 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 885276013474 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 885276013475 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 885276013476 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 885276013477 Na binding site [ion binding]; other site 885276013478 Predicted membrane protein [Function unknown]; Region: COG3162 885276013479 acetyl-CoA synthetase; Provisional; Region: PRK00174 885276013480 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 885276013481 active site 885276013482 CoA binding site [chemical binding]; other site 885276013483 acyl-activating enzyme (AAE) consensus motif; other site 885276013484 AMP binding site [chemical binding]; other site 885276013485 acetate binding site [chemical binding]; other site 885276013486 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 885276013487 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 885276013488 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 885276013489 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 885276013490 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 885276013491 heme lyase subunit NrfE; Provisional; Region: PRK10369 885276013492 Cytochrome C biogenesis protein; Region: CcmH; cl01179 885276013493 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 885276013494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 885276013495 binding surface 885276013496 TPR motif; other site 885276013497 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 885276013498 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 885276013499 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 885276013500 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885276013501 Sel1-like repeats; Region: SEL1; smart00671 885276013502 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 885276013503 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276013504 Walker A/P-loop; other site 885276013505 ATP binding site [chemical binding]; other site 885276013506 Q-loop/lid; other site 885276013507 ABC transporter signature motif; other site 885276013508 Walker B; other site 885276013509 D-loop; other site 885276013510 H-loop/switch region; other site 885276013511 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 885276013512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276013513 Walker A/P-loop; other site 885276013514 ATP binding site [chemical binding]; other site 885276013515 Q-loop/lid; other site 885276013516 ABC transporter signature motif; other site 885276013517 Walker B; other site 885276013518 D-loop; other site 885276013519 H-loop/switch region; other site 885276013520 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 885276013521 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 885276013522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276013523 dimer interface [polypeptide binding]; other site 885276013524 conserved gate region; other site 885276013525 ABC-ATPase subunit interface; other site 885276013526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 885276013527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276013528 dimer interface [polypeptide binding]; other site 885276013529 conserved gate region; other site 885276013530 putative PBP binding loops; other site 885276013531 ABC-ATPase subunit interface; other site 885276013532 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 885276013533 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 885276013534 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 885276013535 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 885276013536 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 885276013537 multidrug resistance protein MdtN; Provisional; Region: PRK10476 885276013538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 885276013539 HlyD family secretion protein; Region: HlyD_3; pfam13437 885276013540 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 885276013541 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 885276013542 D-allose kinase; Provisional; Region: PRK09698 885276013543 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 885276013544 nucleotide binding site [chemical binding]; other site 885276013545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 885276013546 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 885276013547 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 885276013548 substrate binding site [chemical binding]; other site 885276013549 hexamer interface [polypeptide binding]; other site 885276013550 metal binding site [ion binding]; metal-binding site 885276013551 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276013552 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276013553 TM-ABC transporter signature motif; other site 885276013554 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 885276013555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276013556 Walker A/P-loop; other site 885276013557 ATP binding site [chemical binding]; other site 885276013558 Q-loop/lid; other site 885276013559 ABC transporter signature motif; other site 885276013560 Walker B; other site 885276013561 D-loop; other site 885276013562 H-loop/switch region; other site 885276013563 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276013564 D-allose transporter subunit; Provisional; Region: PRK09701 885276013565 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 885276013566 ligand binding site [chemical binding]; other site 885276013567 dimerization interface [polypeptide binding]; other site 885276013568 zinc binding site [ion binding]; other site 885276013569 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 885276013570 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 885276013571 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 885276013572 putative active site [active] 885276013573 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 885276013574 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 885276013575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276013576 Coenzyme A binding pocket [chemical binding]; other site 885276013577 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 885276013578 AAA domain; Region: AAA_18; pfam13238 885276013579 active site 885276013580 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 885276013581 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 885276013582 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 885276013583 active site 885276013584 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 885276013585 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 885276013586 Walker A/P-loop; other site 885276013587 ATP binding site [chemical binding]; other site 885276013588 Q-loop/lid; other site 885276013589 ABC transporter signature motif; other site 885276013590 Walker B; other site 885276013591 D-loop; other site 885276013592 H-loop/switch region; other site 885276013593 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 885276013594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 885276013595 Walker A/P-loop; other site 885276013596 ATP binding site [chemical binding]; other site 885276013597 Q-loop/lid; other site 885276013598 ABC transporter signature motif; other site 885276013599 Walker B; other site 885276013600 D-loop; other site 885276013601 H-loop/switch region; other site 885276013602 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 885276013603 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 885276013604 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 885276013605 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 885276013606 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 885276013607 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 885276013608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276013609 DNA-binding site [nucleotide binding]; DNA binding site 885276013610 UTRA domain; Region: UTRA; pfam07702 885276013611 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 885276013612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 885276013613 dimer interface [polypeptide binding]; other site 885276013614 conserved gate region; other site 885276013615 putative PBP binding loops; other site 885276013616 ABC-ATPase subunit interface; other site 885276013617 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 885276013618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 885276013619 substrate binding pocket [chemical binding]; other site 885276013620 membrane-bound complex binding site; other site 885276013621 hinge residues; other site 885276013622 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 885276013623 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 885276013624 Walker A/P-loop; other site 885276013625 ATP binding site [chemical binding]; other site 885276013626 Q-loop/lid; other site 885276013627 ABC transporter signature motif; other site 885276013628 Walker B; other site 885276013629 D-loop; other site 885276013630 H-loop/switch region; other site 885276013631 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 885276013632 dimer interface [polypeptide binding]; other site 885276013633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 885276013634 hypothetical protein; Provisional; Region: PRK10220 885276013635 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 885276013636 PhnA protein; Region: PhnA; pfam03831 885276013637 hypothetical protein; Provisional; Region: PRK09866 885276013638 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276013639 G1 box; other site 885276013640 GTP/Mg2+ binding site [chemical binding]; other site 885276013641 G2 box; other site 885276013642 Switch I region; other site 885276013643 G3 box; other site 885276013644 Switch II region; other site 885276013645 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 885276013646 G2 box; other site 885276013647 Switch I region; other site 885276013648 G3 box; other site 885276013649 Switch II region; other site 885276013650 G4 box; other site 885276013651 G5 box; other site 885276013652 YjcZ-like protein; Region: YjcZ; pfam13990 885276013653 proline/glycine betaine transporter; Provisional; Region: PRK10642 885276013654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276013655 putative substrate translocation pore; other site 885276013656 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 885276013657 sensor protein BasS/PmrB; Provisional; Region: PRK10755 885276013658 HAMP domain; Region: HAMP; pfam00672 885276013659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276013660 dimer interface [polypeptide binding]; other site 885276013661 phosphorylation site [posttranslational modification] 885276013662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276013663 ATP binding site [chemical binding]; other site 885276013664 Mg2+ binding site [ion binding]; other site 885276013665 G-X-G motif; other site 885276013666 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 885276013667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276013668 active site 885276013669 phosphorylation site [posttranslational modification] 885276013670 intermolecular recognition site; other site 885276013671 dimerization interface [polypeptide binding]; other site 885276013672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276013673 DNA binding site [nucleotide binding] 885276013674 putative metal dependent hydrolase; Provisional; Region: PRK11598 885276013675 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 885276013676 Sulfatase; Region: Sulfatase; pfam00884 885276013677 arginine:agmatin antiporter; Provisional; Region: PRK10644 885276013678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 885276013679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276013680 arginine decarboxylase; Provisional; Region: PRK15029 885276013681 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885276013682 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885276013683 homodimer interface [polypeptide binding]; other site 885276013684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276013685 catalytic residue [active] 885276013686 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885276013687 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 885276013688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276013689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276013690 alpha-galactosidase; Provisional; Region: PRK15076 885276013691 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 885276013692 NAD binding site [chemical binding]; other site 885276013693 sugar binding site [chemical binding]; other site 885276013694 divalent metal binding site [ion binding]; other site 885276013695 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 885276013696 dimer interface [polypeptide binding]; other site 885276013697 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 885276013698 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 885276013699 fumarate hydratase; Provisional; Region: PRK15389 885276013700 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 885276013701 Fumarase C-terminus; Region: Fumerase_C; pfam05683 885276013702 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 885276013703 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 885276013704 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 885276013705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276013706 active site 885276013707 phosphorylation site [posttranslational modification] 885276013708 intermolecular recognition site; other site 885276013709 dimerization interface [polypeptide binding]; other site 885276013710 Transcriptional regulator; Region: CitT; pfam12431 885276013711 sensory histidine kinase DcuS; Provisional; Region: PRK11086 885276013712 PAS domain; Region: PAS; smart00091 885276013713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276013714 ATP binding site [chemical binding]; other site 885276013715 Mg2+ binding site [ion binding]; other site 885276013716 G-X-G motif; other site 885276013717 Uncharacterized conserved protein [Function unknown]; Region: COG3592 885276013718 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 885276013719 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 885276013720 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 885276013721 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 885276013722 dimer interface [polypeptide binding]; other site 885276013723 putative anticodon binding site; other site 885276013724 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 885276013725 motif 1; other site 885276013726 active site 885276013727 motif 2; other site 885276013728 motif 3; other site 885276013729 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 885276013730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276013731 putative substrate translocation pore; other site 885276013732 POT family; Region: PTR2; pfam00854 885276013733 lysine decarboxylase CadA; Provisional; Region: PRK15400 885276013734 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 885276013735 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 885276013736 homodimer interface [polypeptide binding]; other site 885276013737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 885276013738 catalytic residue [active] 885276013739 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 885276013740 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 885276013741 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 885276013742 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276013743 DNA binding site [nucleotide binding] 885276013744 putative transcriptional regulator; Provisional; Region: PRK11640 885276013745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276013746 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 885276013747 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 885276013748 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 885276013749 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 885276013750 DsbD alpha interface [polypeptide binding]; other site 885276013751 catalytic residues [active] 885276013752 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 885276013753 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 885276013754 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 885276013755 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 885276013756 Aspartase; Region: Aspartase; cd01357 885276013757 active sites [active] 885276013758 tetramer interface [polypeptide binding]; other site 885276013759 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 885276013760 putative transporter; Provisional; Region: PRK11021 885276013761 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 885276013762 oligomerisation interface [polypeptide binding]; other site 885276013763 mobile loop; other site 885276013764 roof hairpin; other site 885276013765 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 885276013766 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 885276013767 ring oligomerisation interface [polypeptide binding]; other site 885276013768 ATP/Mg binding site [chemical binding]; other site 885276013769 stacking interactions; other site 885276013770 hinge regions; other site 885276013771 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 885276013772 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 885276013773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276013774 FeS/SAM binding site; other site 885276013775 elongation factor P; Validated; Region: PRK00529 885276013776 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 885276013777 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 885276013778 RNA binding site [nucleotide binding]; other site 885276013779 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 885276013780 RNA binding site [nucleotide binding]; other site 885276013781 entericidin A; Provisional; Region: PRK09810 885276013782 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 885276013783 multidrug efflux system protein; Provisional; Region: PRK11431 885276013784 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 885276013785 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 885276013786 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 885276013787 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 885276013788 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 885276013789 Iron-sulfur protein interface; other site 885276013790 proximal quinone binding site [chemical binding]; other site 885276013791 C-subunit interface; other site 885276013792 distal quinone binding site; other site 885276013793 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 885276013794 D-subunit interface [polypeptide binding]; other site 885276013795 Iron-sulfur protein interface; other site 885276013796 proximal quinone binding site [chemical binding]; other site 885276013797 distal quinone binding site [chemical binding]; other site 885276013798 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 885276013799 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 885276013800 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 885276013801 L-aspartate oxidase; Provisional; Region: PRK06175 885276013802 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 885276013803 poxB regulator PoxA; Provisional; Region: PRK09350 885276013804 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 885276013805 motif 1; other site 885276013806 dimer interface [polypeptide binding]; other site 885276013807 active site 885276013808 motif 2; other site 885276013809 motif 3; other site 885276013810 inner membrane transporter YjeM; Provisional; Region: PRK15238 885276013811 putative mechanosensitive channel protein; Provisional; Region: PRK10929 885276013812 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 885276013813 DNA-binding site [nucleotide binding]; DNA binding site 885276013814 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 885276013815 Mechanosensitive ion channel; Region: MS_channel; pfam00924 885276013816 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 885276013817 GTPase RsgA; Reviewed; Region: PRK12288 885276013818 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 885276013819 RNA binding site [nucleotide binding]; other site 885276013820 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 885276013821 GTPase/Zn-binding domain interface [polypeptide binding]; other site 885276013822 GTP/Mg2+ binding site [chemical binding]; other site 885276013823 G4 box; other site 885276013824 G5 box; other site 885276013825 G1 box; other site 885276013826 Switch I region; other site 885276013827 G2 box; other site 885276013828 G3 box; other site 885276013829 Switch II region; other site 885276013830 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 885276013831 catalytic site [active] 885276013832 putative active site [active] 885276013833 putative substrate binding site [chemical binding]; other site 885276013834 dimer interface [polypeptide binding]; other site 885276013835 epoxyqueuosine reductase; Region: TIGR00276 885276013836 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 885276013837 putative carbohydrate kinase; Provisional; Region: PRK10565 885276013838 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 885276013839 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 885276013840 putative substrate binding site [chemical binding]; other site 885276013841 putative ATP binding site [chemical binding]; other site 885276013842 ADP-binding protein; Provisional; Region: PRK10646 885276013843 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 885276013844 AMIN domain; Region: AMIN; pfam11741 885276013845 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 885276013846 active site 885276013847 metal binding site [ion binding]; metal-binding site 885276013848 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 885276013849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276013850 ATP binding site [chemical binding]; other site 885276013851 Mg2+ binding site [ion binding]; other site 885276013852 G-X-G motif; other site 885276013853 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 885276013854 ATP binding site [chemical binding]; other site 885276013855 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 885276013856 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 885276013857 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 885276013858 bacterial Hfq-like; Region: Hfq; cd01716 885276013859 hexamer interface [polypeptide binding]; other site 885276013860 Sm1 motif; other site 885276013861 RNA binding site [nucleotide binding]; other site 885276013862 Sm2 motif; other site 885276013863 GTPase HflX; Provisional; Region: PRK11058 885276013864 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 885276013865 HflX GTPase family; Region: HflX; cd01878 885276013866 G1 box; other site 885276013867 GTP/Mg2+ binding site [chemical binding]; other site 885276013868 Switch I region; other site 885276013869 G2 box; other site 885276013870 G3 box; other site 885276013871 Switch II region; other site 885276013872 G4 box; other site 885276013873 G5 box; other site 885276013874 FtsH protease regulator HflK; Provisional; Region: PRK10930 885276013875 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 885276013876 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 885276013877 FtsH protease regulator HflC; Provisional; Region: PRK11029 885276013878 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 885276013879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 885276013880 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 885276013881 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 885276013882 GDP-binding site [chemical binding]; other site 885276013883 ACT binding site; other site 885276013884 IMP binding site; other site 885276013885 Predicted transcriptional regulator [Transcription]; Region: COG1959 885276013886 transcriptional repressor NsrR; Provisional; Region: PRK11014 885276013887 exoribonuclease R; Provisional; Region: PRK11642 885276013888 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 885276013889 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 885276013890 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 885276013891 RNB domain; Region: RNB; pfam00773 885276013892 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 885276013893 RNA binding site [nucleotide binding]; other site 885276013894 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 885276013895 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 885276013896 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 885276013897 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 885276013898 PspA/IM30 family; Region: PspA_IM30; pfam04012 885276013899 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 885276013900 Predicted membrane protein [Function unknown]; Region: COG3766 885276013901 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 885276013902 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 885276013903 Predicted integral membrane protein [Function unknown]; Region: COG5463 885276013904 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 885276013905 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 885276013906 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 885276013907 FAD binding site [chemical binding]; other site 885276013908 substrate binding site [chemical binding]; other site 885276013909 catalytic residues [active] 885276013910 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276013911 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 885276013912 esterase; Provisional; Region: PRK10566 885276013913 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 885276013914 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 885276013915 transcriptional repressor UlaR; Provisional; Region: PRK13509 885276013916 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 885276013917 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 885276013918 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 885276013919 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 885276013920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 885276013921 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 885276013922 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 885276013923 active site 885276013924 P-loop; other site 885276013925 phosphorylation site [posttranslational modification] 885276013926 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 885276013927 active site 885276013928 phosphorylation site [posttranslational modification] 885276013929 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 885276013930 active site 885276013931 dimer interface [polypeptide binding]; other site 885276013932 magnesium binding site [ion binding]; other site 885276013933 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 885276013934 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 885276013935 AP (apurinic/apyrimidinic) site pocket; other site 885276013936 DNA interaction; other site 885276013937 Metal-binding active site; metal-binding site 885276013938 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 885276013939 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 885276013940 intersubunit interface [polypeptide binding]; other site 885276013941 active site 885276013942 Zn2+ binding site [ion binding]; other site 885276013943 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 885276013944 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 885276013945 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 885276013946 dimer interface [polypeptide binding]; other site 885276013947 ssDNA binding site [nucleotide binding]; other site 885276013948 tetramer (dimer of dimers) interface [polypeptide binding]; other site 885276013949 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 885276013950 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 885276013951 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 885276013952 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 885276013953 Helix-turn-helix domain; Region: HTH_31; pfam13560 885276013954 sequence-specific DNA binding site [nucleotide binding]; other site 885276013955 salt bridge; other site 885276013956 HipA-like N-terminal domain; Region: HipA_N; pfam07805 885276013957 HipA-like C-terminal domain; Region: HipA_C; pfam07804 885276013958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 885276013959 D-galactonate transporter; Region: 2A0114; TIGR00893 885276013960 putative substrate translocation pore; other site 885276013961 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 885276013962 L-aspartate oxidase; Provisional; Region: PRK06175 885276013963 L-aspartate oxidase; Provisional; Region: PRK06175 885276013964 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 885276013965 Coenzyme A transferase; Region: CoA_trans; smart00882 885276013966 Coenzyme A transferase; Region: CoA_trans; cl17247 885276013967 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 885276013968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 885276013969 substrate binding site [chemical binding]; other site 885276013970 oxyanion hole (OAH) forming residues; other site 885276013971 trimer interface [polypeptide binding]; other site 885276013972 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 885276013973 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 885276013974 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 885276013975 putative NAD(P) binding site [chemical binding]; other site 885276013976 active site 885276013977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 885276013978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 885276013979 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 885276013980 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 885276013981 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 885276013982 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 885276013983 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 885276013984 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 885276013985 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 885276013986 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 885276013987 Hemerythrin-like domain; Region: Hr-like; cd12108 885276013988 Fe binding site [ion binding]; other site 885276013989 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 885276013990 EamA-like transporter family; Region: EamA; pfam00892 885276013991 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 885276013992 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 885276013993 NADP binding site [chemical binding]; other site 885276013994 Predicted transcriptional regulators [Transcription]; Region: COG1733 885276013995 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 885276013996 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 885276013997 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 885276013998 active site 885276013999 metal binding site [ion binding]; metal-binding site 885276014000 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 885276014001 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 885276014002 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 885276014003 active site 885276014004 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 885276014005 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 885276014006 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 885276014007 Domain of unknown function DUF21; Region: DUF21; pfam01595 885276014008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 885276014009 Transporter associated domain; Region: CorC_HlyC; smart01091 885276014010 methionine sulfoxide reductase A; Provisional; Region: PRK00058 885276014011 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 885276014012 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 885276014013 Surface antigen; Region: Bac_surface_Ag; pfam01103 885276014014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 885276014015 Family of unknown function (DUF490); Region: DUF490; pfam04357 885276014016 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 885276014017 putative active site pocket [active] 885276014018 dimerization interface [polypeptide binding]; other site 885276014019 putative catalytic residue [active] 885276014020 Sel1-like repeats; Region: SEL1; smart00671 885276014021 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885276014022 Sel1-like repeats; Region: SEL1; smart00671 885276014023 Sel1-like repeats; Region: SEL1; smart00671 885276014024 Sel1-like repeats; Region: SEL1; smart00671 885276014025 Sel1-like repeats; Region: SEL1; smart00671 885276014026 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 885276014027 Sel1-like repeats; Region: SEL1; smart00671 885276014028 Sel1-like repeats; Region: SEL1; smart00671 885276014029 Sel1-like repeats; Region: SEL1; smart00671 885276014030 Sel1-like repeats; Region: SEL1; smart00671 885276014031 Sel1-like repeats; Region: SEL1; smart00671 885276014032 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 885276014033 dimer interface [polypeptide binding]; other site 885276014034 substrate binding site [chemical binding]; other site 885276014035 metal binding sites [ion binding]; metal-binding site 885276014036 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 885276014037 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 885276014038 putative ligand binding site [chemical binding]; other site 885276014039 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 885276014040 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 885276014041 Walker A/P-loop; other site 885276014042 ATP binding site [chemical binding]; other site 885276014043 Q-loop/lid; other site 885276014044 ABC transporter signature motif; other site 885276014045 Walker B; other site 885276014046 D-loop; other site 885276014047 H-loop/switch region; other site 885276014048 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 885276014049 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276014050 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276014051 TM-ABC transporter signature motif; other site 885276014052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 885276014053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 885276014054 TM-ABC transporter signature motif; other site 885276014055 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 885276014056 AMP binding site [chemical binding]; other site 885276014057 metal binding site [ion binding]; metal-binding site 885276014058 active site 885276014059 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 885276014060 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 885276014061 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 885276014062 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 885276014063 hypothetical protein; Provisional; Region: PRK05255 885276014064 peptidase PmbA; Provisional; Region: PRK11040 885276014065 cytochrome b562; Provisional; Region: PRK15058 885276014066 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 885276014067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276014068 FeS/SAM binding site; other site 885276014069 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 885276014070 ATP cone domain; Region: ATP-cone; pfam03477 885276014071 Class III ribonucleotide reductase; Region: RNR_III; cd01675 885276014072 effector binding site; other site 885276014073 active site 885276014074 Zn binding site [ion binding]; other site 885276014075 glycine loop; other site 885276014076 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 885276014077 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 885276014078 Ca binding site [ion binding]; other site 885276014079 active site 885276014080 catalytic site [active] 885276014081 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 885276014082 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 885276014083 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 885276014084 active site turn [active] 885276014085 phosphorylation site [posttranslational modification] 885276014086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 885276014087 trehalose repressor; Provisional; Region: treR; PRK09492 885276014088 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276014089 DNA binding site [nucleotide binding] 885276014090 domain linker motif; other site 885276014091 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 885276014092 dimerization interface [polypeptide binding]; other site 885276014093 ligand binding site [chemical binding]; other site 885276014094 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 885276014095 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 885276014096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 885276014097 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 885276014098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276014099 motif II; other site 885276014100 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 885276014101 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 885276014102 homotrimer interaction site [polypeptide binding]; other site 885276014103 putative active site [active] 885276014104 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 885276014105 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 885276014106 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 885276014107 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 885276014108 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885276014109 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885276014110 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 885276014111 Arginine repressor [Transcription]; Region: ArgR; COG1438 885276014112 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 885276014113 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 885276014114 Predicted membrane protein [Function unknown]; Region: COG1288 885276014115 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 885276014116 ornithine carbamoyltransferase; Validated; Region: PRK02102 885276014117 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885276014118 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885276014119 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 885276014120 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 885276014121 putative substrate binding site [chemical binding]; other site 885276014122 nucleotide binding site [chemical binding]; other site 885276014123 nucleotide binding site [chemical binding]; other site 885276014124 homodimer interface [polypeptide binding]; other site 885276014125 arginine deiminase; Provisional; Region: PRK01388 885276014126 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 885276014127 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 885276014128 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 885276014129 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 885276014130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 885276014131 RNase E inhibitor protein; Provisional; Region: PRK11191 885276014132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 885276014133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276014134 Coenzyme A binding pocket [chemical binding]; other site 885276014135 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 885276014136 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 885276014137 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 885276014138 HIGH motif; other site 885276014139 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 885276014140 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 885276014141 active site 885276014142 KMSKS motif; other site 885276014143 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 885276014144 tRNA binding surface [nucleotide binding]; other site 885276014145 anticodon binding site; other site 885276014146 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 885276014147 DNA polymerase III subunit chi; Validated; Region: PRK05728 885276014148 multifunctional aminopeptidase A; Provisional; Region: PRK00913 885276014149 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 885276014150 interface (dimer of trimers) [polypeptide binding]; other site 885276014151 Substrate-binding/catalytic site; other site 885276014152 Zn-binding sites [ion binding]; other site 885276014153 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 885276014154 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885276014155 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 885276014156 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 885276014157 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 885276014158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 885276014159 Walker A motif; other site 885276014160 ATP binding site [chemical binding]; other site 885276014161 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 885276014162 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 885276014163 DNA binding site [nucleotide binding] 885276014164 domain linker motif; other site 885276014165 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 885276014166 putative dimerization interface [polypeptide binding]; other site 885276014167 putative ligand binding site [chemical binding]; other site 885276014168 fructuronate transporter; Provisional; Region: PRK10034; cl15264 885276014169 gluconate transporter; Region: gntP; TIGR00791 885276014170 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 885276014171 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 885276014172 NADP binding site [chemical binding]; other site 885276014173 homodimer interface [polypeptide binding]; other site 885276014174 active site 885276014175 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 885276014176 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 885276014177 putative NAD(P) binding site [chemical binding]; other site 885276014178 catalytic Zn binding site [ion binding]; other site 885276014179 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 885276014180 ATP-binding site [chemical binding]; other site 885276014181 Gluconate-6-phosphate binding site [chemical binding]; other site 885276014182 Shikimate kinase; Region: SKI; pfam01202 885276014183 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 885276014184 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 885276014185 putative NAD(P) binding site [chemical binding]; other site 885276014186 putative substrate binding site [chemical binding]; other site 885276014187 catalytic Zn binding site [ion binding]; other site 885276014188 structural Zn binding site [ion binding]; other site 885276014189 dimer interface [polypeptide binding]; other site 885276014190 integrase; Provisional; Region: PRK09692 885276014191 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276014192 active site 885276014193 Int/Topo IB signature motif; other site 885276014194 HNH endonuclease; Region: HNH_2; pfam13391 885276014195 Protein of unknown function DUF91; Region: DUF91; cl00709 885276014196 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 885276014197 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 885276014198 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 885276014199 Methyltransferase domain; Region: Methyltransf_26; pfam13659 885276014200 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 885276014201 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 885276014202 TIGR02687 family protein; Region: TIGR02687 885276014203 PglZ domain; Region: PglZ; pfam08665 885276014204 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 885276014205 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 885276014206 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 885276014207 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 885276014208 Transposase; Region: HTH_Tnp_1; cl17663 885276014209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 885276014210 putative transposase OrfB; Reviewed; Region: PHA02517 885276014211 HTH-like domain; Region: HTH_21; pfam13276 885276014212 Integrase core domain; Region: rve; pfam00665 885276014213 Integrase core domain; Region: rve_3; pfam13683 885276014214 Predicted GTPase [General function prediction only]; Region: COG3596 885276014215 YfjP GTPase; Region: YfjP; cd11383 885276014216 Switch I region; other site 885276014217 G2 box; other site 885276014218 Switch II region; other site 885276014219 G3 box; other site 885276014220 G4 box; other site 885276014221 G5 box; other site 885276014222 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 885276014223 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 885276014224 hypothetical protein; Provisional; Region: PRK09945 885276014225 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 885276014226 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 885276014227 Autotransporter beta-domain; Region: Autotransporter; smart00869 885276014228 hypothetical protein; Provisional; Region: PRK09866 885276014229 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276014230 G1 box; other site 885276014231 GTP/Mg2+ binding site [chemical binding]; other site 885276014232 G2 box; other site 885276014233 Switch I region; other site 885276014234 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 885276014235 G3 box; other site 885276014236 Switch II region; other site 885276014237 GTP/Mg2+ binding site [chemical binding]; other site 885276014238 G4 box; other site 885276014239 G5 box; other site 885276014240 YjcZ-like protein; Region: YjcZ; pfam13990 885276014241 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 885276014242 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 885276014243 nucleophile elbow; other site 885276014244 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 885276014245 Domain of unknown function (DUF932); Region: DUF932; pfam06067 885276014246 Antirestriction protein; Region: Antirestrict; pfam03230 885276014247 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 885276014248 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 885276014249 MPN+ (JAMM) motif; other site 885276014250 Zinc-binding site [ion binding]; other site 885276014251 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 885276014252 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 885276014253 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 885276014254 active site 885276014255 Int/Topo IB signature motif; other site 885276014256 Restriction endonuclease [Defense mechanisms]; Region: COG3587 885276014257 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 885276014258 ATP binding site [chemical binding]; other site 885276014259 putative Mg++ binding site [ion binding]; other site 885276014260 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 885276014261 DNA methylase; Region: N6_N4_Mtase; cl17433 885276014262 DNA methylase; Region: N6_N4_Mtase; pfam01555 885276014263 DNA methylase; Region: N6_N4_Mtase; cl17433 885276014264 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 885276014265 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 885276014266 putative active site [active] 885276014267 catalytic site [active] 885276014268 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 885276014269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276014270 ATP binding site [chemical binding]; other site 885276014271 putative Mg++ binding site [ion binding]; other site 885276014272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 885276014273 nucleotide binding region [chemical binding]; other site 885276014274 ATP-binding site [chemical binding]; other site 885276014275 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 885276014276 WYL domain; Region: WYL; pfam13280 885276014277 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 885276014278 Protein of unknown function DUF91; Region: DUF91; cl00709 885276014279 Homeodomain-like domain; Region: HTH_23; pfam13384 885276014280 Winged helix-turn helix; Region: HTH_29; pfam13551 885276014281 Domain of unknown function (DUF303); Region: DUF303; pfam03629 885276014282 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 885276014283 Kelch motif; Region: Kelch_1; pfam01344 885276014284 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 885276014285 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 885276014286 Int/Topo IB signature motif; other site 885276014287 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 885276014288 Int/Topo IB signature motif; other site 885276014289 Fimbrial protein; Region: Fimbrial; cl01416 885276014290 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276014291 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 885276014292 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 885276014293 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 885276014294 outer membrane usher protein; Provisional; Region: PRK15193 885276014295 PapC N-terminal domain; Region: PapC_N; pfam13954 885276014296 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 885276014297 PapC C-terminal domain; Region: PapC_C; pfam13953 885276014298 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276014299 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 885276014300 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 885276014301 mannosyl binding site [chemical binding]; other site 885276014302 Fimbrial protein; Region: Fimbrial; pfam00419 885276014303 fructuronate transporter; Provisional; Region: PRK10034 885276014304 gluconate transporter; Region: gntP; TIGR00791 885276014305 mannonate dehydratase; Region: uxuA; TIGR00695 885276014306 mannonate dehydratase; Provisional; Region: PRK03906 885276014307 D-mannonate oxidoreductase; Provisional; Region: PRK15037 885276014308 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 885276014309 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 885276014310 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 885276014311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276014312 DNA-binding site [nucleotide binding]; DNA binding site 885276014313 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276014314 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 885276014315 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 885276014316 cell density-dependent motility repressor; Provisional; Region: PRK10082 885276014317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 885276014318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 885276014319 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 885276014320 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 885276014321 dimer interface [polypeptide binding]; other site 885276014322 active site 885276014323 hypothetical protein; Provisional; Region: PRK10519 885276014324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 885276014325 Nucleoside recognition; Region: Gate; pfam07670 885276014326 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 885276014327 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 885276014328 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 885276014329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 885276014330 SdiA-regulated; Region: SdiA-regulated; cd09971 885276014331 putative active site [active] 885276014332 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 885276014333 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 885276014334 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 885276014335 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 885276014336 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 885276014337 Predicted membrane protein [Function unknown]; Region: COG2733 885276014338 putative transposase; Provisional; Region: PRK09857 885276014339 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 885276014340 Uncharacterized conserved protein [Function unknown]; Region: COG1479 885276014341 Protein of unknown function DUF262; Region: DUF262; pfam03235 885276014342 Protein of unknown function DUF262; Region: DUF262; pfam03235 885276014343 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 885276014344 Uncharacterized conserved protein [Function unknown]; Region: COG3586 885276014345 endoribonuclease SymE; Provisional; Region: PRK13605 885276014346 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 885276014347 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 885276014348 HsdM N-terminal domain; Region: HsdM_N; pfam12161 885276014349 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 885276014350 Methyltransferase domain; Region: Methyltransf_26; pfam13659 885276014351 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 885276014352 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 885276014353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 885276014354 ATP binding site [chemical binding]; other site 885276014355 putative Mg++ binding site [ion binding]; other site 885276014356 Uncharacterized conserved protein [Function unknown]; Region: COG1479 885276014357 Protein of unknown function DUF262; Region: DUF262; pfam03235 885276014358 Protein of unknown function DUF262; Region: DUF262; pfam03235 885276014359 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 885276014360 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 885276014361 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 885276014362 P-loop, Walker A motif; other site 885276014363 Base recognition motif; other site 885276014364 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 885276014365 Uncharacterized small protein [Function unknown]; Region: COG2879 885276014366 carbon starvation protein A; Provisional; Region: PRK15015 885276014367 Carbon starvation protein CstA; Region: CstA; pfam02554 885276014368 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 885276014369 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 885276014370 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 885276014371 dimer interface [polypeptide binding]; other site 885276014372 ligand binding site [chemical binding]; other site 885276014373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276014374 dimerization interface [polypeptide binding]; other site 885276014375 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 885276014376 dimer interface [polypeptide binding]; other site 885276014377 putative CheW interface [polypeptide binding]; other site 885276014378 DctM-like transporters; Region: DctM; pfam06808 885276014379 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 885276014380 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 885276014381 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 885276014382 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 885276014383 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 885276014384 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 885276014385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 885276014386 DNA-binding site [nucleotide binding]; DNA binding site 885276014387 Transcriptional regulators [Transcription]; Region: GntR; COG1802 885276014388 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 885276014389 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 885276014390 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 885276014391 putative NAD(P) binding site [chemical binding]; other site 885276014392 catalytic Zn binding site [ion binding]; other site 885276014393 structural Zn binding site [ion binding]; other site 885276014394 phosphoglycerol transferase I; Provisional; Region: PRK03776 885276014395 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 885276014396 hypothetical protein; Provisional; Region: PRK11667 885276014397 DNA replication protein DnaC; Validated; Region: PRK07952 885276014398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 885276014399 Walker A motif; other site 885276014400 ATP binding site [chemical binding]; other site 885276014401 Walker B motif; other site 885276014402 primosomal protein DnaI; Provisional; Region: PRK02854 885276014403 hypothetical protein; Provisional; Region: PRK09917 885276014404 Uncharacterized conserved protein [Function unknown]; Region: COG2966 885276014405 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 885276014406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 885276014407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276014408 DNA binding residues [nucleotide binding] 885276014409 dimerization interface [polypeptide binding]; other site 885276014410 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 885276014411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 885276014412 DNA binding residues [nucleotide binding] 885276014413 dimerization interface [polypeptide binding]; other site 885276014414 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 885276014415 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 885276014416 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 885276014417 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 885276014418 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 885276014419 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 885276014420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 885276014421 S-adenosylmethionine binding site [chemical binding]; other site 885276014422 DNA polymerase III subunit psi; Validated; Region: PRK06856 885276014423 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 885276014424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 885276014425 Coenzyme A binding pocket [chemical binding]; other site 885276014426 dUMP phosphatase; Provisional; Region: PRK09449 885276014427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276014428 motif II; other site 885276014429 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 885276014430 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 885276014431 G1 box; other site 885276014432 putative GEF interaction site [polypeptide binding]; other site 885276014433 GTP/Mg2+ binding site [chemical binding]; other site 885276014434 Switch I region; other site 885276014435 G2 box; other site 885276014436 G3 box; other site 885276014437 Switch II region; other site 885276014438 G4 box; other site 885276014439 G5 box; other site 885276014440 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 885276014441 periplasmic protein; Provisional; Region: PRK10568 885276014442 BON domain; Region: BON; pfam04972 885276014443 BON domain; Region: BON; pfam04972 885276014444 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 885276014445 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 885276014446 active site 885276014447 nucleophile elbow; other site 885276014448 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 885276014449 active site 885276014450 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 885276014451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 885276014452 FeS/SAM binding site; other site 885276014453 hypothetical protein; Provisional; Region: PRK10977 885276014454 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 885276014455 intersubunit interface [polypeptide binding]; other site 885276014456 active site 885276014457 catalytic residue [active] 885276014458 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 885276014459 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 885276014460 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 885276014461 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 885276014462 phosphopentomutase; Provisional; Region: PRK05362 885276014463 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 885276014464 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 885276014465 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 885276014466 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 885276014467 HipA-like N-terminal domain; Region: HipA_N; pfam07805 885276014468 HipA-like C-terminal domain; Region: HipA_C; pfam07804 885276014469 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 885276014470 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 885276014471 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 885276014472 hypothetical protein; Provisional; Region: PRK11246 885276014473 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 885276014474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 885276014475 motif II; other site 885276014476 DNA repair protein RadA; Region: sms; TIGR00416 885276014477 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 885276014478 Walker A motif/ATP binding site; other site 885276014479 ATP binding site [chemical binding]; other site 885276014480 Walker B motif; other site 885276014481 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 885276014482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276014483 non-specific DNA binding site [nucleotide binding]; other site 885276014484 salt bridge; other site 885276014485 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 885276014486 sequence-specific DNA binding site [nucleotide binding]; other site 885276014487 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 885276014488 active site 885276014489 (T/H)XGH motif; other site 885276014490 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 885276014491 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 885276014492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 885276014493 non-specific DNA binding site [nucleotide binding]; other site 885276014494 salt bridge; other site 885276014495 sequence-specific DNA binding site [nucleotide binding]; other site 885276014496 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 885276014497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 885276014498 Walker A/P-loop; other site 885276014499 ATP binding site [chemical binding]; other site 885276014500 Q-loop/lid; other site 885276014501 ABC transporter signature motif; other site 885276014502 Walker B; other site 885276014503 D-loop; other site 885276014504 H-loop/switch region; other site 885276014505 ABC transporter; Region: ABC_tran_2; pfam12848 885276014506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 885276014507 lytic murein transglycosylase; Provisional; Region: PRK11619 885276014508 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 885276014509 N-acetyl-D-glucosamine binding site [chemical binding]; other site 885276014510 catalytic residue [active] 885276014511 Trp operon repressor; Provisional; Region: PRK01381 885276014512 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 885276014513 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 885276014514 catalytic core [active] 885276014515 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 885276014516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 885276014517 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 885276014518 hypothetical protein; Provisional; Region: PRK10756 885276014519 CreA protein; Region: CreA; pfam05981 885276014520 DNA-binding response regulator CreB; Provisional; Region: PRK11083 885276014521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276014522 active site 885276014523 phosphorylation site [posttranslational modification] 885276014524 intermolecular recognition site; other site 885276014525 dimerization interface [polypeptide binding]; other site 885276014526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276014527 DNA binding site [nucleotide binding] 885276014528 sensory histidine kinase CreC; Provisional; Region: PRK11100 885276014529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 885276014530 dimerization interface [polypeptide binding]; other site 885276014531 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 885276014532 dimer interface [polypeptide binding]; other site 885276014533 phosphorylation site [posttranslational modification] 885276014534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 885276014535 ATP binding site [chemical binding]; other site 885276014536 Mg2+ binding site [ion binding]; other site 885276014537 G-X-G motif; other site 885276014538 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 885276014539 two-component response regulator; Provisional; Region: PRK11173 885276014540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 885276014541 active site 885276014542 phosphorylation site [posttranslational modification] 885276014543 intermolecular recognition site; other site 885276014544 dimerization interface [polypeptide binding]; other site 885276014545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 885276014546 DNA binding site [nucleotide binding]